Short Biography

Anna Maria Papini, PhD

Professor and Chair of Bioorganic Chemistry _______________________________________________________________________________________

Interdepartmental French-Italian Laboratory of Peptide & Protein Chemistry & Biology

www.peptlab.eu

Education and Scientific Graduation

Since 2013: Scientific National Habilitation to the function of Full Professor of Organic Chemistry of the

Italian Universities.

Since 2001: Habilitation to the function of Full Professor of Organic Chemistry of the French Universities.

1985-1989: International Ph.D. in Chemical Biology of the Italian Ministry of Education. 1985-1986

Department of Biochemistry, University of Sherbrooke, Québec, Mentor Prof. Dr. Gilles Dupuis; 1986-1988

Dept. of Organic Chemistry, University of Florence, Mentor: Prof. Gianfranco. Rapi and 1988-1989

Department of Peptide Chemistry, Max Planck Institute für Biochemie, Martinsried Bei Muenchen, Mentor

Prof. Dr. Luis Moroder.

1977-1983: Italian “Laurea” in Chemistry, Curriculum Organic Chemistry & Chemical Biology of the

University of Florence (Italy).

Research Experience and Employment History

Since 2002 to date: Associate Professor and Chair of Bioorganic Chemistry of the University of Florence.

Since 2008 to date: Full Professor and Chair of Bioorganic Chemistry of the University of Cergy-Pontoise.

Since 2010 to date: Founder and coordinator of the French-Italian Laboratory of Peptide & Protein

Chemistry & Biology (www.peptlab.eu) University of Florence & University of Cergy-Pontoise.

Since 2013 to date: Director of the Platform PeptLab@UCP at the University of Cergy-Pontoise.

Since 2004 to date: Co-founder and head of the Interdepartmental Laboratory of Peptide & Protein

Chemistry & Biology, Polo Scientifico of the University of Florence associating the Departments of

Chemistry, Pharmaceutical Sciences & Neurosciences of the University of Florence.

1991-2001: Researcher at the Department. of Organic Chemistry, University of Florence.

Awards and Activities in the Scientific Community

2009-2014: Chaire d’excellence of the French Agence Nationale de la Recherche.

2008: Leonidas Zervas Award for outstanding contribution to peptide chemistry, 30th EPS, Helsinki.

2008: 1st D. Theodoropoulos Memorial Lecture Award for outstanding achievements in Peptide Sciences,

6th Hellenic Forum on Bioactive Peptides, Patras.

2005: Bert Schram Price. Honorable Mention, 19th APS, San Diego, CA, USA.

2005: Best Poster Award “Glyco XVIII”, Firenze.

1999: Bruce W. Erickson Award for outstanding achievement in peptide sciences, 16th APS, Minneapolis,

Minnesota, USA.

2012-2016: Panel Member for ERC Advanced Grant evaluation PE5 – Synthetic chemistry and materials.

2016: Chairperson of the 2016 GRC: Chemistry & Biology of Peptides with Prof. Dr. P. Dawson.

2014: Chairperson of the Symposium & Training Course Peptides in Paris PIPS 2014 (Co-chairs Prof. S.

Lavielle & Prof. W.D. Lubell), October 5-10, 2014, Institute if Advanced Studies, University of Cergy-Pontoise

(France).

2014: Responsible of the thematic semester Peptides & Proteins Molecules of Life at the University of

Cergy-Pontoise.

2014: Vice-chair of the GRC: Peptide Science in the Era of Synthetic Biology. Ventura, CA, 23-28/02/2014.

2011-2020: Treasurer and member of the Executive Committee of the European Peptide Society.

February 2011: Member of the AERES Committee for evaluation of the ICM of the University of Reims.

March 2010: Member of the AERES Committee for evaluation of iBiTecc-S Equipe SIMOPRO (CEA, Saclay).

Since 2013: Coordinator of the International Affairs of the School of Sciences of the University of Florence.

Since 2005: Delegate of Chemistry of the Erasmus Programme of the Faculty of Sciences of the University of

Florence. Responsible of the Erasmus students

2009: Vespucci Award for founding the startup Toscana Biomarkers.

2008: Frost & Sullivan Excellence in Research Award in the European autoimmune disease diagnostics

market presented to AMP for the startup Toscana Biomarkers.

2006: Start-Cup for business plan of the start-up Toscana Biomarkers.

2004: Vespucci Award, Research & Ethical Innovation to AMP as inventor of PCT (2003) WO 03000733 A2.

2007 to date: Founder & Chief Scientific Officer of the startup Toscana Biomarkers

(www.toscanabiomarkers.com)

2003: Founder and member of the Board of EspiKem, 1st spinoff of the University of Florence

(www.espikem.com)

Recent Research Funding

2009-2014: “Chaire d’Excellence” (ANR-09-CEXC-013-01). PepKit: Development of peptide-based-

diagnostic kits for autoimmune diseases. 999.998,00 Euro for the PeptLab@UCP platform.

2011-2013: “Fondation Pierre-Gilles de Gennes”. Immune-mediated diseases: Glycopeptidomic-based

diagnostics to follow-up disease activity. 2 post-doctoral fellows + 90.000 Euro for materials.

2010-2012: “Regione Toscana POR CReO FESR”. MARK: Identification of diagnostic biomarkers of

autoimmune diseases. 450.000,00 Euro.

2005-2011: “Fondazione Cassa di Risparmio di Firenze”. Molecular characterisation of peptide-protein

interaction in autoimmune diseases. 1.500.000 Euro for PeptLab at University of Florence.

2005-2007: International FIRB- Italian Ministry of University & Research and Harvard Medical School.

350.000,00 Euro.

2002-2003, 2005-2006, 2008-2009: PRIN-Italian Ministry of University & Research. Design, synthesis &

immunological characterisation of modified peptides to follow up autoimmune diseases. 700.000,00 Euro.

Selected topic-relevant research publications

Author of 281 peer-reviewed articles: 111 articles in peer reviewed scientific journals and 170 articles in

peer reviewed books. Author of 10 filed patents. Full paper list is available at www.peptlab.eu

1. A.M. Papini, F. Nuti, F. Real-Fernandez, G. Rossi, C. Tiberi, G. Sabatino, S. Pandey, S. Leoncini, C. Signorini,

A. Pecorelli, R. Guerranti, S. Lavielle, L. Ciccoli, P. Rovero, C. De Felice, J. Hayek. Immune dysfunction in Rett

syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction. J. Immunology Res.

(http://www.hindawi.com/journals/jir/raa/260973/). Accepted 15 September 2014.

2. A. Naegeli, C. Neupert, Y-Y Fan, C-W Chia-Wei Lin, K. Poljak, A.M. Papini, F. Schwarz, M. Aebi. Molecular

analysis of an alternative N-glycosylation machinery by functional transfer from Actinobacillus

pleuropneumoniae to Escherichia coli. J. Biol. Chem. (2014), 24, 289, 2170-2179.

3. S. Pandey, I. Dioni, D. Lambardi, F. Real-Fernandez, E. Peroni, G. Pacini, F. Lolli, R. Seraglia, A.M. Papini,

and P. Rovero. Alpha actinin is specifically recognized by multiple sclerosis autoantibodies isolated using an

N-glucosylated peptide epitope. Mol. Cell. Proteomics (2013) Feb;12(2):277-82.

4. S. Pandey, M.C. Alcaro, M. Scrima, E. Peroni, I. Paolini, S. Di Marino, F. Barbetti, A. Carotenuto, E.

Novellino, A.M. Papini, A.M. D'Ursi, and P. Rovero. Designed glycopeptides mimetics of myelin protein

epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis.

J.Med.Chem. (2012) Dec 13;55(23):10437-47.

5. C. Testa, F. Nuti, J. Hayek, C. De Felice, M. Chelli, P. Rovero, G. Latini, and A.M. Papini. Di(2-

ethylhexyl)phthalate and Autism Spectrum Disorders. ASN NEURO (American Society for Neurochemistry)

(2012) 4(4), 223-229

6. F. Nuti, E. Peroni, F. Real-Fernández, M.A. Bonache, A. Le Chevalier-Isaad, M. Chelli, N. Lubin-Germain, J.

Uziel, P. Rovero, F. Lolli, and A.M. Papini. Post-translationally modified peptides efficiently mimicking neo-

antigens: a challenge for theragnostics of autoimmune diseases. Biopolymers: Peptide Science (2010) 94, 6,

791-799.

7. A.M. Papini. The use of post-translationally modified peptides for detection of biomarkers of immune-

mediated diseases. J. Pept. Sci. (2009), 15, 621-628.

8. A. Carotenuto, M.C. Alcaro, M.R. Saviello, E. Peroni, F. Nuti, A.M. Papini, E. Novellino, and P. Rovero.

Designed glycopeptides with different β-turn types as synthetic probes for the detection of autoantibodies,

biomarkers of Multiple Sclerosis. J. Med. Chem. (2008) 51, 5304-5309.

9. A. Carotenuto, A.M. D’Ursi, B. Mulinacci, I. Paolini, F. Lolli, A.M. Papini, E. Novellino, and P. Rovero.

Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of

autoantibodies, biomarkers of multiple sclerosis. J. Med. Chem. (2006) 49, 5072-5079.

10. F. Lolli, B. Mulinacci, A. Carotenuto, B. Bonetti, G. Sabatino, B. Mazzanti, A.M. D’Ursi, E. Novellino, M.

Pazzagli, L. Lovato, M.C. Alcaro, E. Peroni, M.C. Pozo-Carrero, F. Nuti, L. Battistini, G. Borsellino, M. Chelli, P.

Rovero, and A.M. Papini. An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers

of Multiple Sclerosis. Proc. Natl. Acad. Sci., U.S.A. (2005) 102(29), 10273-10278.

11. A.M. Papini. Simple test for Multiple Sclerosis. Nature Medicine (2005) 11(1), 13.

12. F. Lolli, B. Mazzanti, M. Pazzagli, E. Peroni, M.C. Alcaro, R. Lanzillo, V. Brescia Morra, L. Santoro, C.

Gasperini, S. Galgani, M.M. D’ Elios, V. Zipoli, S. Sotgiu, M. Pugliatti, P. Rovero, M. Chelli, and A.M. Papini.

The glycopeptide CSF114(Glc) detects serum antibodies in Multiple Sclerosis. J. Neuroimmunol. (2005)

167(1-2), 131-137.

Communication of the scientific activity

2001-2014: invited to present 94 lectures in International Symposia, Universities and Research Centres.

1997-2014: 38 oral & 206 poster communications selected in international symposia.

2009-2013: invited to present 10 lectures aimed to technology transfer in the global space of R&D (2 in

extra-European countries and 8 in Europe).

Supervisor of diploma/master/bachelor and PhD theses

Supervisor of 16 finalized PhD theses as well as 24 diploma and master theses. Tutor of Erasmus students:

18 Traineeship for periods going from 4 months till 1 year, 12 Master and 6 PhD students.

Snap-shot of the group (as of June 2014): 5 PhDs; 5 Post-docs; 1 Ingénieur de recherche; 2 Associate

Professors; 5 Master students; 3 Bachelor students; 3 Erasmus placement students.

Curriculum Vitae

PROF. ANNA MARIA PAPINI, PhD Nata a Firenze il 2 Febbraio 1959 Nazionalità Italiana e Francese Professore Associato di Chimica Organica all’Università di Firenze Chaire d’Excellence de l’Agence Nationale de la Recherche Laboratorio Interdipartimentale di Chimica e Biologia di Peptidi e Proteine PeptLab Dipartimento di Chimica “Ugo Schiff” Via della Lastruccia 13 50019 Sesto Fiorentino annamaria.papini@unifi.it Tel. +39-3478844146

Firenze, 6 Novembre 2014

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Formazione e titoli professionali Laurea DL in Chimica Conseguito presso: Università degli Studi di Firenze Data conseguimento: 1983 Titolo della tesi di laurea “Funzionalizzazione Regioselettiva di eteri e tioeteri ciclici: sintesi di derivati bifunzionali via composti organometallici del gruppo IVB” Relatore: Prof. A. Ricci Dottorato di ricerca 1986-1989: Borsa del Ministero della Pubblica Istruzione per il Corso di Dottorato di Ricerca in Scienze Chimiche III Ciclo (Curriculum Chimica Organica Sintetica). Conseguito presso: Università degli Studi di Firenze e Max Planck Institut fuer Biochemie (Martinsried, Germania). Data conseguimento: 1990. Titolo della tesi: "Sintesi di peptidi e loro studio sotto il profilo chimico, bio-farmacologico ed immunologico". Tutori L. Moroder, MPI fuer Biochemie e G. Rapi, Dip.to Chimica Organica, Università di Firenze. Diploma di specializzazione 1985: Borsa di Studio del Ministero della Pubblica Istruzione per il settore 1, Scienze Chimiche, per la frequenza di attività di specializzazione presso istituzioni estere di livello universitario (G.U. 79, 22.3.83). Conseguito presso: Faculté de Médecine, Université de Sherbrooke, Centre hospitalier universitaire de Sherbrooke (Québec). Data conseguimento: 1985. Progetto: Meccanismi molecolari delle dermatiti allergiche da contatto. Tutore Prof. G. Dupuis. Abilitazione alla professione di chimico Conseguita presso: Università degli Studi di Firenze. Data conseguimento: 1984. Iscritta all'Ordine dei Chimici della Toscana dal 1984 e eletta Consigliere per il quadriennio 2010-2013 e Segretario per il quadriennio 2013-2016. Abilitazione a Professeur des Universités francaises (n° qualif. 01132111096). Conseguita presso: Ministère de l'Education Nationale (Francia). Data conseguimento: 2001. Prima classificata al concorso per titoli ed esami (JO n.50-28.02.2001) per Professeur 32PR0788 Università di Lyon-1 (profilo: Molecole bioattive, Chimica biomimetica). Abilitazione a Professeur des Universités francaises (n° qualif. 05132111096). Conseguita presso: Ministère de l'Education Nationale (Francia). Data conseguimento: 2005. Prima classificata al concorso per titoli ed esami (JO 28.02.2008) per Professeur 32PR0396 Université Cergy-Pontoise (profilo: Sintesi organica, biomolecole e analoghi). Attività professionale in Italia Dal 1991 al 2001: Tecnico laureato afferente al Dipartimento di Chimica Organica dell’Università di Firenze. Dal 2001 al 2002: Ricercatore Universitario della Facoltà di SMFN dell’Università di Firenze, afferente al Dipartimento di Chimica Organica dell’Università di Firenze. Dal 2002 ad oggi: Professore Associato SSD CHIM/06 - Chimica Organica presso il Dipartimento di Chimica dell’Università di Firenze. Da Dicembre 2013: Abilitazione Scientifica Nazionale per Prima Fascia, Settore Concorsuale 03/C1 Chimica Organica. Domanda n. 29153 (parametri bibliometrici superiori alle mediane). Attività professionale internazionale 2009-2014 Lauréate della Chaire d'Excellence dell’Agence Nationale de la Recherche Ed. 2009 (Francia). Chaire d’Excellence Sénior Longue Durée (60 mesi) (ANR-09-CEXC-013-01), unica di chimica su 16 per tutte le discipline per il Progetto PepKit ed organizzare la "European Infrastructure of Peptide Chemistry and Biology” accolta dall’Université de Cergy-Pontoise. Conseguimento di premi e riconoscimenti per l'attività scientifica 2008: LEONIDAS ZERVAS AWARD 2008 attribuito ad Anna Maria Papini FOR OUTSTANDING CONTRIBUTION TO PEPTIDE CHEMISTRY. Il premio è stato consegnato al 30th European Peptide Symposium, Helsinki (Finlandia) il 31 Agosto 2008 successivamente alla presentazione della conferenza: "Peptide-based immunoassays for biomarkers detection: a challenge for translational research". 2008: 1st DIMITRIOS THEODOROPOULOS MEMORIAL LECTURE AWARD attribuito ad Anna Maria Papini FOR OUTSTANDING ACHIEVEMENTS IN PEPTIDE SCIENCES. Il premio è stato consegnato al 6th Hellenic Forum on Bioactive Peptides, Patrasso (Grecia) il 18 Maggio 2008 successivamente alla presentazione della conferenza: A "Chemical Reverse Approach" to modified peptides as synthetic antigenic probes to detect autoantibodies as biomarkers of multiple sclerosis. 2006: PREMIO LUIGI SENATORE attribuito al XXXV Congresso Nazionale della Divisione di Chimica Fisica della Società Chimica Italiana a Firenze, 10-15 Settembre 2006 per la presentazione poster: V. Volkov, F. Nuti, Y.Takaoka, R. Chelli, A.M. Papini, and R. Righini. Structure and bonding of water molecules in the polar region of phospholipid membrane investigated by two-dimensional IR spectroscopy and MD computer simulation (Abstract FIS-P-135).

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2005: BEST POSTER AWARD attribuito al XVIII International Symposium on Glycoconjugates "Glyco XVIII" a Firenze, 4-9 Settembre 2005 per la presentazione poster: F. Nuti, I. Paolini, B.Mulinacci, M. Pazzagli, F. Lolli, M. Chelli, P. Rovero, and A.M. Papini. Sugar-scan of CSF114(Glc) for autoantibody recognition in Multiple Sclerosis [Abstract P057, Glycoconjugate J., 2005, 22(46), 254]. 2005: BERT SCHRAM PRICE HONORABLE MENTION attribuito al 19th American Peptide Symposium a San Diego, CA, USA, 18-24 Giugno 2005 per la comunicazione orale allo Young Investigator Mini-Symposium: B. Mulinacci, C. Breithaupt, P.P. Pal, N. Budisa, M. Pazzagli, B. Mazzanti, P. Rovero, L. Moroder, and A.M. Papini. Cross-reactivity studies of rMOGED with the synthetic putative autoantigen CSF114(Glc) and [N31(Glc)]hMOG(30-50) in Multiple Sclerosis patients' sera (LY 03, Abstract p. 484]. 1999: BRUCE W. ERICKSON AWARD FOR OUTSTANDING ACHIEVEMENT IN PEPTIDE SCIENCES attribuito al 16th American Peptide Symposium a Minneapolis, MN, USA, 26 Giugno-1 Luglio 1999 per la presentazione poster: E. Nardi, S. Mazzucco, S. Matà, M. Chelli, B. Mazzanti, E. Traggiai, M. Ginanneschi, F. Pinto, L. Massacesi, M. Vergelli, H. Kalbacher, F. Lolli and A.M. Papini. Influence of different N-linked glycosyl moiety at position 31 of hMOG(30-50) on anti-MOG antibody recognition in multiple sclerosis patients (Abstract P148, pag. 227). Comunicazione dell’attività scientifica Coautore di 181 pubblicazioni scinetifiche di cui 111 in riviste internazionali peer reviewed e 70 capitoli di libri peer reviewed. Inoltre e’ coautrice di 11 brevetti. Attività di valutatore di progetti scientifici nazionali e internazionali EUROPEAN REASEARCH COUNCIL (ERC, BRUXELLES) Per il periodo 2012-2016 è stata nominata dall'ERC e ha fatto parte in qualità di Membro Esperto del Comitato per la Valutazione del Panel PE5 "Synthetic Chemistry and Materials" per la valutazione dei progetti europei Advanced Grant (partecipazione alla prima commissione di valutazione in due step: Maggio e Settembre 2012). AGENCE NATIONALE DE LA RECHERCHE (ANR, PARIGI) 2014: E’ stata nominata dall’ANR a far parte del panel di valutazione delle pre-proposals per il processo di selezione di progetti da finanziare nel 2015 in Francia. 2010: E' stata nominata dall'ANR e ha fatto parte in qualità di membro esperto/rapporteur/lecteur del Comitato per la valutazione dei progetti presentati ai programmi Blanc (91 progetti) et Jeune Chercheurs/Jeunes chercheuses (37 progetti) del bando AAP Edition 2010 SIMI 7 (Chimie moléculaire, organique, de coordination, catalyse et chimie biologique) (Parigi, La Défense, commissione di valutazione in due step: gennaio 2010 e maggio 2010). AGENCE D'EVALUATION DE LA RECHERCHE ET DE L'ENSEIGNEMENT SUPERIEUR (AERES, FRANCIA) Febbraio 2011: E' stata nominata dall'AERES e ha fatto parte in qualità di Membro Esperto del Comitato per la Valutazione della ricerca e l'insegnamento dell'Institut de Chimie Moléculaire di Reims, Université de Reims Champagne Ardenne (Francia), Direttore M.X. Coqueret. Marzo 2010: E' stata nominata dall'AERES e ha fatto parte in qualità di Membro Esperto del Comitato per la Valutazione della ricerca e l'insegnamento dell'Institute of Biology and Technology di Saclay (iBiTecc-S) Equipe Service d'Ingénierie Moléculaire des Protéines (SIMOPRO) CEA Saclay, Gif sur Yvette (Francia), Direttore Vincent Dive. FONDATION DE LA RECHERCHE MÉDICALE (FRM, PARIGI) Nel 2011 e nel 2012 ha fatto parte in qualità di Membro Esperto del Comitato per la Valutazione dei progetti presentati alla FRM - Appel d'offres 2011 e 2012 Programme Pionniers de la Recherche, Chimie pour la Médecine (valutazioni in due step Giugno e Dicembre 2011 e 2012). Dal 2012 al 2015. Valutatore dei progetti selezionati in itinere. ASSOCIATION NATIONALE RECHERCHE TECHNOLOGIE (ANRT, PARIGI) 2011-2013 Valutatore di Dossiers CIFRE (Conventions Industrielles de Formation par la Recherche). VIENNA SCIENCE AND TECHNOLOGY FUND 2014: Reviewer di proposte per Vienna Research Groups for Young Investigators, call in the field of “Life Sciences” (http://wwtf.at/programmes/ls/index.php?lang=EN#c4136h). NATIONAL SCIENCE CENTRE IN POLAND (Narodowe Centrum Nauki - NCN; http://www.ncn.gov.pl). 2014: Reviewer di progetti Funding scheme PRELUDIUM. FONDATION PARTENARIALE DELL'UNIVERSITÉ DE CERGY-PONTOISE Nel 2011 e nel 2012 ha fatto parte in qualità di Membro Esperto del Consiglio Scientifico per la Valutazione dei progetti del settore Chimica presentati alla fondazione (valutazioni in due step Febbraio e Dicembre 2011 e 2012). Partecipazione a Comitati Scientifici di start-up Dal 2007: Presidente del Comitato Scientifico di Toscana Biomarkers Srl, Toscana Life Sciences Foundation (www.toscanabiomarkers.com). Dal 2009: Membro del Comitato Scientifico di EspiKem Slr (www.espikem.com). Dal 2013: Membro del Comitato Scientifico di REGULAXIS, Parc scientifique Biocitech (www.regulaxis.com). ATTIVITA' DI REFEREE ESTERNO DI PROGETTI PRESENTATI AD AGENZIE INTERNAZIONALI e DI RIVISTE 2005-2013: E' stata esperto esterno per la Valutazione di numerosi progetti di bandi dall'ANR francese

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(programmi Blanc SIMI 7 ; Blanc SIMI 10, Programma Emergence, Programma JCJC SIMI 7 per la Chimica), Ligue Nationale Contre le Cancer, Dossiers CIFRE, Division for Chemical Sciences (CW) of the Netherlands Organisation for Scientific Research (NWO) for TOP grants; Israeli Science Foundation, Hebrew University, DFG (Germania), ecc. Referee di numerose e prestigiose riviste quali J.Med.Chem., Nature, Nature Medicine, PNAS, JACS, JOC, EurJOC, THL, Tetrahedron, ecc. Gestione di progetti scientifici nazionali e internazionali Responsabile Unità PRIN 2002: Sviluppo e validazione di nuovi approcci terapeutici immuno-mediati per malattie demielinizzanti autoimmuni del sistema nervoso centrale; rilevanza per la sclerosi multipla. Coordinatore Progetto PRIN 2005: Progettazione, sintesi e caratterizzazione immunologica di nuovi glicopeptidi mimetici di autoantigeni mielinici per lo studio dei meccanismi molecolari della sclerosi multipla e per lo sviluppo di strumenti diagnostici innovativi Coordinatore Progetto PRIN 2008: Progettazione, sintesi e caratterizzazione immunologica di peptidi modificati per la diagnosi ed il "follow-up" di malattie autoimmuni Coordinatore Progetto FIRB Internazionalizzazione 2005: Studio del ruolo degli zuccheri nella eziologia della sclerosi multipla. Responsabile Unità 2010-2012 - POR CReO FESR 2007-2013 Regione Toscana - Bando Regionale 2009 per il Sostegno a Progetti di ricerca industriale e sviluppo sperimentale congiunti tra piccole e medie imprese e organismi di ricerca in materia di salute: Progetto MARK (Identificazione di biomarker diagnostici per malattie autoimmuni) – Euro 176.000,00 Collaboratore Unità 2011-2013 PAR FAS Regione Toscana Linea di Azione 1.1.a.3 "Avviso pubblico regionale 2009 per il sostegno a progetti di ricerca in materia di scienze socio economiche e umane" (decreto n. 155 del 13/01/10) Progetto S.I.C.A.M.O.R. ("Sviluppo di Indagini Chimiche Applicate al Mantenimento delle Opere e al Restauro") Euro 192.000,00 Coordinatore Progetto 2009-2011 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Produzione di antigeni peptidici e proteici per la diagnosi e la terapia dell'autoimmunità, con particolare riferimento alle malattie orfane. Euro 140.000,00 per strumentazione e assegni di ricerca. Responsabile Unità 2008-2010 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Studio dell'interazione peptidi-proteine. Euro 440.000,00 per l'acquisto di uno strumento BIACORE e assegni di ricerca. Coordinatore Progetto 2004-2005 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Caratterizzazione molecolare e cellulare di antigeni implicati nella patogenesi della sclerosi multipla - Euro 840.000,00 per l'acquisto di un sistema integrato di purificazione di peptidi e proteine, di un citofluorimetro e di uno spettrometro di massa ad alta risoluzione Responsabile Unità 2005-2006 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Sviluppo di una piattaforma tecnologica per lo studio delle interazioni di farmaci con proteine di membrana - Euro 200.000,00 per l'acquisto di sintetizzatori di peptidi, HPLC e assegni di ricerca. Coordinatore di progetto 2009-2014 - Agence Nationale de la Recherche Programme Chaire d'Excellence di Chimica Edition 2009 Categoria Sénior longue durée (ANR-09-CEXC-013-01) (unica di chimica su 16 attribuite per tutte le discipline). Progetto PepKit: Development of peptide-based-diagnostic kits for autoimmune diseases. Organizzazione della Piattaforma e Laboratorio italo-francese PeptLab c/o Département de Chimie dell'Université de Cergy-Pontoise e Laboratorio interdipartimentale di Chimica e Biologia di Peptidi e Proteine (Dipartimento di Chimica e NEUROFARBA dell’Università di Firenze) – Euro 999.998,00 Euro. Responsabile Unità 2011-2013 – Fondation Pierre-Gilles de Gennes pour la recherche - Projet n° 40, «Immune-mediated diseases: Glycopeptidomic-based diagnostics to follow up disease activity» in collaborazione con la Prof. S. Lavielle, UPMC-ENS Paris - due postdoctoral fellowship, 2x18 months e 90.000,00 Euro per materiali. Responsabile Unità 2005-2006 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Strategie innovative per la lotta alle malattie causate da batteri fitopatogeni: sintesi di peptidi e proteine - Euro 192.000,00 per l'acquisto di strumentazione per la purificazione e caratterizzazione di biomolecole e assegni di ricerca. Responsabile Unità 2007 - Programme Action Integrées Galilée n°14418SL, Université Franco-Italienne University of Florence (PeptLab) & Université de Cergy-Pontoise/Lab. SOSCO - Progetto Synthèse d'acides aminés glycosylés pour l'obtention de glycopeptides pour le diagnostic et le pronostic de la sclérose en plaques. Euro 4.000,00 per scambio di ricercatori. Responsabile Unità 2006 - Programme Action Integrées Galilée N°11686QA, Université Franco-Italienne University of Florence (PeptLab) & Université de Dijon (CNRS, UMR 5188) - Progetto: Métallopeptides électrodétectables appliqués au diagnostic et à la thérapie des pathologies autoimmunes. Euro 4.000,00 per scambio di ricercatori). Coordinatore di progetto

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2001 - Fondazione Lieselotte und Dr. Karl Otto Winkler (Germania) - Progetto: Sintesi dei metaboliti del (2-etilesil)ftalato (DEHP) e del dibutilftalato (DBP) - Euro 4.906,00. Coordinatore di progetto 1996-1999 - Istituto Superiore di Sanità - Ministero della Sanità - Progetto Sclerosi Multipla - Progetto di Ricerca: Caratterizzazione della risposta linfocitaria verso peptidi e lipopeptidi della proteina basica della mielina umana nella sclerosi multipla. Finanziamento: £ 155.000.000 Responsabilità amministrative ed altre responsabilità collettive in Italia 2013-2015 Eletta Segretario dell’Ordine dei Chimici della Toscana 2013-2015 Eletta membro e Tesoriere del Consiglio dell’Associazione dei Dottori Chimici della Toscana (Registro Regionale personalità giuridica 8 agosto 2013 n. 895). 2013-2015 Eletta membro e presidente del Comitato Pari Opportunità del Consiglio Nazionale dei Chimici 2011-2013 Membro fondatore e membro del Consiglio dell’Associazione dei Dottori Chimici della Toscana. 2011-2013 Eletta Consigliere dell’Ordine dei Chimici della Toscana 2002-2003: Nominata dal Direttore del Dipartimento di Chimica Organica membro della Commissione per l’organizzazione del Master di II livello “Metodologie di Sintesi in Chimica Organica”, del Dipartimento di Chimica Organica “Ugo Schiff”. 2002: Nominata dal Direttore del Dipartimento di Chimica Organica “Ugo Schiff” membro del Comitato organizzatore per l’Open day del Dipartimento, nell’ambito della XII Settimana della Cultura Scientifica in Toscana. 2000-2003: Eletta rappresentante del personale non docente al Consiglio del Dipartimento di Chimica Organica « Ugo Schiff » dell’Università di Firenze. 1992-1995: Eletta rappresentante del personale non docente al Consiglio del Dipartimento di Chimica Organica « Ugo Schiff » dell’Università di Firenze. Dal 1997: Fondatrice e Presidente dell’A.H.R.T.E. (Association of High Research Technology Experts). ATTIVITA' NELL'AMBITO DI SOCIETA' SCIENTIFICHE INTERNAZIONALI 2000-2013: nominata rappresentante accademico per l'Italia nel Board della Society of Combinatorial Chemistry. 2004-2008: nominata membro della Scientific Affairs Committee della European Peptide Society quale riconoscimento internazionale del suo contributo scientifico alla chimica dei peptidi. 2011-2015 nominata Tesoriere e membro della Executive Committee della European Peptide Society insieme al Presidente Prof. F. Hudecz, Direttore del Dipartimento di Chimica della Eötvös Loránd University a Budapest (Ungheria), al Segretario Prof. D. Tourwe del Dipartimento di Chimica Organica della Vrije Universiteit Brussel (Belgio), al Scientific Affairs Officer Prof. S. Lavielle, Direttrice del Laboratoire des Biomolecules della Universitè Pierre et Marie Curie/Ecole Normale Superieure di Parigi (Francia) e al Communication Affairs Officer Prof. P. Cordopatis, Direttore del dipartimento di farmacognosia e chimica delle sostanze naturali dell'Università di Patrasso (Grecia). 2016-2020 viene nominata per un secondo mandato Tesoriere e membro della Executive Committee della European Peptide Society insieme al Presidente Prof. D. Andreu, Pompeu Fabra University, Barcelona (Spagna), Segretario Prof. D. Tourwe del Dipartimento di Chimica Organica della Vrije Universiteit Brussel (Belgio), al Scientific Affairs Officer Prof. N. Sewald, University of Bielefeld, Department of Chemistry, Organic and Bioorganic Chemistry (Germany) e al Communication Affairs Officer Prof. K. Rolka, University of Gdansk (Polonia). ATTIVITÀ DI COMUNICAZIONE SCIENTIFICA DI ANNA MARIA PAPINI ALL'ESTERO DEI RISULTATI DELLA RICERCA E DEL TRASFERIMENTO TECNOLOGICO. DATI RIASSUNTIVI 81 PRESENTAZIONI ORALI (57 IN EUROPA E 24 IN PAESI EXTRA-EUROPEI) NEL PERIODO 1997-2013 DI CUI 77 NEL PERIODO 2001-2012 (55 IN EUROPA E 22 IN PAESI EXTRA-EUROPEI) DELLE QUALI 62 SU INVITO (45 IN EUROPA E 17 IN PAESI EXTRA-EUROPEI) INCLUSE LE LECTURE PER L'ATTRIBUZIONE DEL LEONIDAS ZERVAS MEMORIAL LECTURE AWARD (HELSINKI) E DIMITRIOS THEODOROPOULOS MEMORIAL LECTURE AWARD (PATRASSO). IN DETTAGLIO: NEL PERIODO 2003-2014 È STATA INVITATA A PRESENTARE 22 LECTURES IN UNIVERSITÀ E CENTRI DI RICERCA INTERNAZIONALI (14 IN EUROPA E 8 IN PAESI EXTRAEUROPEI). In particolare 2 nel 2003: (Francia: Institut de Biologie Moléculaire et Cellulaire, Strasbourg; INSERM E209, Hôpital Saint-Antoine, Parigi); 1 nel 2004 : (Francia : Laboratoire de Synthése et Electrosynthése et Organométalliques UMR CNRS 5188 Universitè De Bourgogne, Dijon); 4 nel 2005 (Israele: Weizmann Institute of Science Rehovot invitata dal Prof M. Sela; Spagna: Seminaris del Parc Cientific de Barcelona-Universitat de Barcelona; 2 in Francia: Laboratoire d'Ingénierie moléculaire pour la séparation et les applications des Gaz « LIMSAG » (UMR 5633) Université de Bourgogne, Dijon; Institut de Chimie des Substances Naturelles, Gif-sur-Y vette); 4 nel 2007 (2 in Israele: Judea & Samaria College, Ariel; Department of Chemistry, Bar-Ilan University - Ramat-Gan; 2 in Australia: Howard Florey Institute, University of Melbourne; Burnet Institute, Austin Campus, Heidelberg); 2 nel 2009 (1 in Giappone: Prefectural University of Osaka; 1 in Spagna: Barcelona Biomedical Research Park, PRBB-CRG Seminar, Pompeu Fabra University); 2 nel 2010 (USA: Juvenil Diabetes Research Foundation Workshop Role of Beta Cell Antigen Modifications in the Pathogenesis of T1D and their Diagnostic and Therapeutic Potential, New York City; 1 in Francia: Université de Versailles, Saint Quentin en Yvelines); 5 nel 2011 (5 in Francia: INSERM U829/Laboratoire "Structure-Activité des Biomolécules Normales et Pathologiques" Université d'Evry-Val d'Essonne ; Ecole Doctorale Sciences Chimiques BALARD 459 dell'Université de Montpellier 2; ICOA - UMR 6005 - Université d'Orléans; iBiTec-S - CEA/Saclay, Gif sur Yvette; Cycle thématique "Dynamiques des systèmes complexes" : Modélisation de

6

macromolécules biologiques" - Organisateur Pr. R. Livi, St Martin, Université de Cergy-Pontoise) 1 nel 2012 (1 in Canada: Department of Chemistry of the University of Montreal) ; 1 nel 2013 (Department of Chemistry, Karlsruhe University). NEL PERIODO 2001-2014 HA PRESENTATO 37 CONFERENZE SU INVITO O PLENARY LECTURES A CONGRESSI INTERNAZIONALI (30 IN EUROPA E 7 IN PAESI EXTRA-EUROPEI) Una nel 2001 (Grecia : 2nd Medicinal Chemistry Conference University of Patras); 2 nel 2002 (1 in Grecia: 3rd Medicinal Chemistry Conference University of Patras; 1 in UK: Intensive Course: "Synthesis for Solving Biological Problems" - Newcastle upon Tyne); 2 nel 2003 (1 in Italia : 1st Practical Training Course "Innovative combinatorial approaches and technologies" Firenze; 1 in Germania : Italian-German Mini Symposium on Peptides and Proteins. "Structure and Molecular Recognition" Max Planck Institut für Biochemie, Martinsried); 2 nel 2004 (1 in Grecia: 5th Conference "Medicinal Chemistry: Drug Design and Development", University of Patras; 1 in Italia: 9th Naples Workshop, Peptides as Therapeutic, Diagnostics & Vaccines); 1 nel 2005 (Giappone: European-Japanese Bioorganic Meeting, 15-19 Marzo 2005, Okayama); 1 nel 2006: (Irlanda: 5th annual Centre for Synthesis and Chemical Biology - CSCB symposium, Dublino); 4 nel 2007: (2 in Israele: Israeli-Italian Bi-National Conference - Brain functions and The 6th Congress of the Israeli association for Medicinal Chemistry, Weizmann Institute of Science, Rehovot; 2 in Australia: Modern Solid Phase Peptide Synthesis & its applications - Satellite meeting of the 7th International Australian Peptide Symposium, Port Douglas; Peptide Users Group", Spring Symposium, Mimotopes, Melbourne) 6 nel 2008: (1 in Irlanda: 3rd ERA Chemistry Conference "Carbohydrates at the interfaces of biology, medicine and materials science", Killarney; 1 in Grecia: 6th Hellenic Forum on Bioactive Peptides - Patrasso - 1st Dimitrios Theodoropoulos Memorial Lecture Award; 1 in Finlandia: 30th European Peptide Symposium Helsinki -Leonidas Zervas Memorial Lecture Award; 1 in Bulgaria: 5th Bulgarian Peptide Symposium, Rila Mountain; 1 in USA: 6th International Microwaves in Chemistry Conference, Cambridge, MA; 1 in Spagna: Barcelona BioMed Conference Peptide engineering: Therapeutic peptides); 4 nel 2009 (1 in Spagna: Barcelona Biomedical Research Park, PRBB-CRG Seminar, Pompeu Fabra University, Barcelona; 1 in Francia: MAOPS, Microwave Assisted Organic and Peptide Synthesis - La Grande Motte; 1 in Austria: 11th International Congress on Amino Acids, Peptides and Proteins, Wien; 1 in Belgio: "Does size matter? Beyond small molecule therapeutics: challenges and success stories"Université Libre de Bruxelles) ; 1 nel 2011 (Italia: Italian-German Meeting: Green and Sustainable Approach to Process Intensification, Torino); 6 nel 2012 (1 in USA : Gordon Research Conference Carbohydrates Colby College, Waterville; 2 in Grecia: 1st See-Drug Workshop From chemical to systems biology Peptide synthesis and protein production, Patras; 32nd European Peptide Symposium, Athens; 1 in Italia: 13th Naples Workshop on Bioactive Peptides; 1 in Germania: Saxon Biotechnology Symposium - Centre for Biotechnology and Biomedicine BIO CITY LEIPZIG, 1 in Austria: Austrian peptide Symposium, Wien). 2 nel 2013 (1 in Polonia al 22nd Polish Peptide Symposium e 1 a Praga (Cecoslovaccha) 4th Annual EuroPeptides); 3 nel 2014 (1 a Parigi, 1ère Edition des rencontres interdisciplinaires «Chimie-Biologie». SATT idfinnov, 1 a Lake Balaton (Ungheria), Hungarian Peptide Symposium e 1 a Napoli al 14th Naples Workshop on Bioactive Peptides “The Renaissance era of Peptides in Drug Discovery”. Esperienze professionali all’estero Insegnamento e Ricerca Insegnamento e Ricerca. 10/2009 09/2014: Agence Nationale de la Recherche Programme Chaire d'Excellence di Chimica Biorganica Edition 2009 Categoria Sénior longue durée (ANR-09-CEXC-013-01) (unica di chimica su 16 attribuite per tutte le discipline) Progetto PepKit: Development of peptide-based diagnostic kits for autoimmune diseases. Organizzazione del Laboratorio italo-francese PeptLab c/o Département de Chimie dell'Université de Cergy-Pontoise. Insegnamento e Ricerca. 04/2008 05/2008: Département de Chimie dell'Université de Cergy-Pontoise (Francia) - Professore invitato di Chimica Organica - Posizione 32 PR 0396. Insegnamento e Ricerca. 06/2005 07/2005: Institut de Chimie Moléculaire Universitaire de Bourgogne dell'Université de Bourgogne dell'Académie de Dijon (Francia) –Posizione 30 PR 0239. Insegnamento e Ricerca. 06/1999 07/1999: Département de Chimie dell'Université de Cergy-Pontoise (Francia) -Professore invitato di Chimica Organica - Posizione 032 PR 8019. Insegnamento e Ricerca. 01/1998 07/1998: Département de Chimie dell'Université de Cergy-Pontoise (Francia) Professore invitato di Chimica Organica - Posizione PAST 8035. Ricerca. 06/1999 07/1999: Medizinisch Naturwissenschaftliches Forschungszentrum dell'Università di Tübingen (Germania) - Progetto di Scambio Vigoni-DAAD: Studio del ruolo della MOG, peptidi e glicopeptidi come nuovi antigeni in malattie neurologiche. Ricerca. 10/1988 10/1989: Max Planck Institut für Biochemie, Abteilung Peptidchemie, Martinsried, Germania (Prof. Dr. L. Moroder). Ricerca. 03/1985 12/1985: Dipartimento di Biochimica (Facoltà di Medicina), Università di Sherbrooke (Québec) (G.U. 79, 22.3.83). Insegnamento. 09/2010 09/2010: Abant Izzet Baysal University, Faculty of Arts & Sciences, Bolu (Turchia) - Master e PhD in Chemistry - LLP Erasmus Teaching Mobility (AF N° 2009-1-IT2-ERA02-09056). Insegnamento. 09/2010 09/2010: University of Balikesir (Turchia) - Master in Chemistry - LLP Erasmus Teaching Mobility (AF N° 2009-1-IT2-ERA02-09056). Insegnamento. 07/2010 07/2010: Università di Patrasso (Grecia) - Master in Medicinal Chemistry – LLP Erasmus Teaching Mobility (AF N° 2009-1-IT2-ERA02-09056). Insegnamento. 10/2010 10/2010: University of Gdansk (Polonia) - Master in Chemistry - LLP Erasmus Teaching Mobility (AF N° 2009-1-IT2-ERA02-09056).

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Insegnamento. 09/2012 09/2012: Università di Patrasso (Grecia) - Master in Medicinal Chemistry – LLP Erasmus Teaching Mobility (AF N° 2011-1-IT2-ERA02-25889). Insegnamento. 12/2004 12/2004 : Université Henry Poincare Nancy 1, Faculté des Sciences et Techniques, Nancy (Francia) - D.E.A. Microbiologie-Enzymologie-Nutrition (Aspects Moléculaires et Cellulaires), Magistére Microbiologie-Enzymologie (3éme année). Module Biophysique et Biologie Structurale. COLLABORAZIONI INTERNAZIONALI E INVITI DI CONFERENZIERI PRESSO IL DIPARTIMENTO DI CHIMICA E LA SCUOLA DI DOTTORATO IN SCIENZE CHIMICHE DELL'UNIVERSITA' DI FIRENZE.

Nel periodo 2001-2014 Anna Maria Papini ha collaborato con importanti centri di ricerca come dimostrato dai numerosi articoli in rivista e brevetti oltre ai numerosi abstract di congressi e contributi in volumi:

STATI UNITI: 1) Laboratory of Translational Research, Harvard Medical School, Cambridge, MA, Prof. M. Chorev; 2) Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, Prof. E. Gershwin; 3) Department of Chemistry Dartmouth College, Hannover, NH, Prof. D. Mierke.

POLONIA: Institute of Organic Chemistry, Technical University of Lodz, Prof. Z. Kaminski (113,116,120,180,185,186). FRANCIA: 1) LSEO UMR 5632, ICMUB, Université de Bourgogne, Dijon, Prof. S. Jugè e Prof. F. Denat; 2) PeptLab-SOSCO, N. Lubin-Germain e J. Uziel, Université de Cergy-Pontoise ; 3) Laboratoire d'Imagerie et Neurosciences Cognitives, INSERM UMR7237, Université de Strasbourg, Prof. J. de Seze (3).

GRECIA : Department of Chemistry, University of Patras, Prof. J. Matsoukas. SVIZZERA : Institute of

Pathology, University Berne, Prof. J.C. Reubl.

GERMANIA: MNF Universität Tübingen Dr. S. Hidenbrand e Dr. H. Kalbacher.

NEL PERIODO 2003-2012 ANNA MARIA PAPINI HA INVITATO 36 CONFERENZIERI STRANIERI IN DETTAGLIO: 2003: 1) Prof. A. Kapurniotu, University Hospital of the RWTH Aachen; 2) Prof. I. Toth, University of Queensland, St Lucia; 3) Dr. B. 't Hart, Biomedical Primate Research Centre, Department of Immunobiology, Rijswick. 2004: 1) Prof. Z. Kaminski, Institute of Organic Chemistry, Technical University of Lodz; 2) Prof. I. P. Gerothanassis, Department of Chemistry, University of Ioannina; 3) Prof. B. Golding, School of Natural Sciences and Chemistry, University of Newcastle upon Tyne;4) Dr. A. Aubry LCM3B, Université Henri Poincaré Nancy I. 2005: 1) Prof. M. Sela The W. Garfield Weston Professor of Immunology, Department of Immunology, The Weizmann Institute of Science, Rehovot; 2) Prof. L. Moroder Department of Bioorganic Chemistry, Max-Planck Institut für Biochemie, Martinsried; 3) Prof. J.-Y Lallemand Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette; 4) Prof. J. Matsoukas, Department of Chemistry, University of Patras; 5) Dr. E. Stura, Département d'Ingénierie et d'Etudes des Protéines, CEA, Saclay; 6) Prof. M. Chorev, Laboratory for Translational Research, Harvard Medical School, Cambridge, MA; 7) Prof. F. Albericio, Department of Organic Chemistry, University of Barcelona. 2006: 1) Prof. F. Naider The College of Staten Island, New York, USA; 2) Prof. K. J. Jensen Bioorganic Chemistry, Department of Natural Sciences, Royal Veterinary and Agricultural University, Copenhagen; 3) Dr. J. Uziel Laboratoire SOSCO CNRS UMR 8123, Université de Cergy-Pontoise; 4) Dr. S. Pegoraro 4SC AG, Martnsried. 2007: 1) Prof. M. Chorev, Laboratory for Translational Research, Harvard Medical School, Cambridge, MA; 2) Prof. M. Fridkin Department of Organic Chemistry, Weizmann Institute of Sciences, Rehovot; 3) Prof. C. Gilon Department of Organic Chemistry, The Hebrew University, Jerusalem. 2008: 1) Dr C. W Gruber Institute for Molecular Bioscience, Chemical and Structural Biology, QLD, Australia; 2) Prof. R M.J. Liskamp Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences; 3) Prof. K. Soo Hahm Research Center for Proteineous Materials and Department of Cellular Molecular Medicine, School of Medicine, Chosun University, Kwangju Republic of Korea; 4) Prof. T. Brigaud Laboratoire SOSCO CNRS UMR 8123, Université de Cergy-Pontoise; 5) Dr. J.-F. Hernandez Institut des Biomolécules Max Mousseron, CNRS UMR5247, Universités Montpellier I and II; 6) Prof. T. Kilpatrick Neuroscience Victoria. 2009: 1) Prof. C. Amatore, ENS, Parigi; 2) Prof. E. Perez-Paya, Instituto de Biomedicina de Valencia CSIC. 2010: 1) Prof. I. Fujii, Dept. of Biological Science, Osaka Prefecture University. 2011: 1) Dr. R. Ahroni, Department of Immunology, The Weizmann Institute of Science, Rehovot; 2) Dr. R. Varma, US Environmental Protection Agency, Cincinnati, Ohio. 2012: 1) Prof. G.A. Spyroulias, Department of Pharmacy, University of Patrasso; 2) Prof. F. Naider The College of Staten Island, New York, USA; 3) Prof. Dr. A. Robitzki Center for Biotechnology and Biomedicine, University of Leipzig; 4) Prof. J. Wade, University of Melbourne. 2013 : 1) Prof. T. Torroba, Università di Burgos

Questa attività è stata favorita anche grazie a Fondi di Ateneo per l'Internazionalizzazione della ricerca di cui è stata Responsabile scientifico (bandi 2005, 2006 e 2008 per un totale di 8200,00 Euro).

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Gestione di progetti scientifici nazionali e internazionali

Progetto Durata (mesi)

Ruolo ricoperto

PRIN 2002: Sviluppo e validazione di nuovi approcci terapeutici immuno-mediati per malattie demielinizzanti autoimmuni del sistema nervoso centrale; rilevanza per la sclerosi multipla.

24

Responsabile Unità

PRIN 2005: Progettazione, sintesi e caratterizzazione immunologica di nuovi glicopeptidi mimetici di autoantigeni mielinici per lo studio dei meccanismi molecolari della sclerosi multipla e per lo sviluppo di strumenti diagnostici innovativi.

24 Coordinatore Progetto

PRIN 2008: Progettazione, sintesi e caratterizzazione immunologica di peptidi modificati per la diagnosi ed il "follow-up" di malattie autoimmuni

24

Coordinatore Progetto

FIRB Internazionalizzazione 2005 (in coll. Con Harvard Medical School): Studio del ruolo degli zuccheri nella eziologia della sclerosi multipla

36

Coordinatore Progetto

2010-2012 - POR CReO FESR Regione Toscana - Bando Regionale 2009 per il Sostegno a Progetti di ricerca industriale e sviluppo sperimentale congiunti tra piccole e medie imprese e organismi di ricerca in materia di salute: Progetto MARK (Identificazione di biomarker diagnostici per malattie autoimmuni) - Euro 176.000,00.

24

Responsabile Unità

2011-2013 PAR FAS Regione Toscana Linea di Azione 1.1.a.3 "Avviso pubblico regionale 2009 per il sostegno a progetti di ricerca in materia di scienze socio economiche e umane" (decreto n. 155 del 13/01/10) Progetto S.I.C.A.M.O.R. ("Sviluppo di Indagini Chimiche Applicate al Mantenimento delle Opere e al Restauro") Euro 192.000,00.

24

Collaboratore Unità

2013-2014 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Sviluppo di biomarcatori delle malattie dello spettro autistico per il follow-up dei pazienti e la messa a punto di terapie anti-neurodegenerative. Euro 30.000,00 per assegni di ricerca

24 Coordinatore Progetto

2009-2011 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Produzione di antigeni peptidici e proteici per la diagnosi e la terapia dell'autoimmunità, con particolare riferimento alle malattie orfane. Euro 140.000,00 per strumentazione e assegni di ricerca

36 Coordinatore Progetto

2008-2010 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto:

Studio dell'interazione peptidi-proteine. Euro 440.000,00 per l'acquisto di uno strumento BIACORE e assegni di ricerca

36

Responsabile Unità

2004-2005 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Caratterizzazione molecolare e cellulare di antigeni implicati nella patogenesi della sclerosi multipla - Euro 840.000,00 per l'acquisto di un sistema integrato di purificazione di peptidi e proteine, di un citofluorimetro e di uno spettrometro di massa ad alta risoluzione

24 Coordinatore Progetto

2005-2006 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Sviluppo di una piattaforma tecnologica per lo studio delle interazioni di farmaci con proteine di membrana - Euro 200.000,00 per l'acquisto di sintetizzatori di peptidi, HPLC e assegni di ricerca

18 Responsabile Unità

2005-2006 - Fondazione Ente Cassa di Risparmio di Firenze - Progetto: Strategie innovative per la lotta alle malattie causate da batteri fitopatogeni: sintesi di peptidi e proteine - Euro 192.000,00 per l'acquisto di strumentazione per la purificazione e caratterizzazione di biomolecole e assegni di ricerca

24

Responsabile Unità

2011-2013 – Fondation Pierre-Gilles de Gennes pour la recherche - Projet n° 40, «Immune-mediated diseases: Glycopeptidomic-based diagnostics to follow up disease activity» in collaborazione con la Prof. S. Lavielle, UPMC-ENS Paris - due postdoctoral fellowship, 2x18 months e 90.000,00 Euro per materiali

18

Responsabile Unità

2007 - Programme Action Integrées Galilée n°14418SL, Université Franco-Italienne University of Florence (PeptLab) & Université de Cergy-Pontoise/Lab. SOSCO - Progetto Synthèse d'acides aminés glycosylés pour l'obtention de glycopeptides pour le diagnostic et le pronostic de la sclérose en plaques. Euro

12 Responsabile Unità

9

4.000,00 per scambio di ricercatori

2006 - Programme Action Integrées Galilée N°11686QA, Université Franco-Italienne University of Florence (PeptLab) & Université de Dijon (CNRS, UMR 5188) - Progetto: Métallopeptides électrodétectables appliqués au diagnostic et à la thérapie des pathologies autoimmunes. Euro 4.000,00 per scambio di ricercatori

12

Responsabile Unità

2001 - Fondazione Lieselotte und Dr. Karl Otto Winkler (Germania) - Progetto: Sintesi dei metaboliti del (2-etilesil)ftalato (DEHP) e del dibutilftalato (DBP) - Euro 4.906,00

12

Coordinatore di progetto

1996-1999 - Istituto Superiore di Sanità - Ministero della Sanità - Progetto Sclerosi Multipla - Progetto di Ricerca: Caratterizzazione della risposta linfocitaria verso peptidi e lipopeptidi della proteina basica della mielina umana nella sclerosi multipla. Finanziamento: £ 155.000.000

36

Coordinatore di progetto

Organizzazioni di eventi scientifici

NEL PERIODO 2003-2014 HA ORGANZZATO COME CHAIRPERSON 6 CONGRESSI E 3 TRAINING COURSES. 2016 Nominata CHAIRPERSON DELLA GORDON RESEARCH CONFERENCE EDIZIONE 2016 "THE PEPTIDES, CHEMISTRY & BIOLOGY" INSIEME A J.P. DAWSON (THE SCRIPPS RESEARCH INSTITUTE, DEPARTMENTS OF CELL BIOLOGY AND CHEMISTRY, LA JOLLA - CA) QUALE RICONOSCIMENTO DELL'ELEVATO LIVELLO SCIENTIFICO NEL SETTORE DELLA CHIMICA BIORGANICA DEI PEPTIDI. 2014: Chairperson dell’International Peptides in Paris Symposium PIPS 2014 e Training Course 5-10 Ottobre 2014, Université de Cergy Pontoise (Francia) come evento finale della Chaire d’Excellence e responsabile del semestre tematico Peptides & Proteins Molecules of Life. Febbraio 2014 CO-CHAIR DELLA GORDON RESEARCH CONFERENCE EDIZIONE 2014 "THE PEPTIDES, CHEMISTRY & BIOLOGY"

2011: "PEPTIDES AND PROTEINS IN THE NEW MILLENNIUM" che ha organizzato in onore del Dottorato Honoris Causa conferito dall'Università di Cergy-Pontoise al Prof. Luis Moroder a Neuville-sur-Oise (Francia), 5-6 Ottobre, 2011 (Ospite d'onore il premio Nobel Robert Huber). In quell'occasione Anna Maria Papini ha presentato la "Laudatio" alla Carriera Scientifica di Luis Moroder.

2011: MICROWAVE-ASSISTED ORGANIC PEPTIDE SYNTHESIS 2 - MAOPS2, Chiostro del Maglio, Firenze (Italy), 26-28 Aprile 2011.

2010: 1ST ITALY-AUSTRALIA PEPTIDE SYMPOSIUM ON BIOMOLECULES FOR DIAGNOSTICS & THERAPEUTICS, Satellite del 31st European Peptide Symposium, Monash University Prato (Italia), 10-12 Settembre, 2010.

2007: EUROCOMBI4, 1ST INTERNATIONAL SYMPOSIUM ON COMBINATORIAL SCIENCES IN BIOLOGY, CHEMISTRY, CATALYSTS AND MATERIALS, Chiostro del Maglio, Firenze (Italia), 15-18 Luglio, 2007.

2006: INTERNATIONAL TRAINING COURSE ON MASS SPECTROMETRY & HIGH PERFORMANCE LIQUID CHROMATOGRAPHY OF PROTEINS (sponsorizzato dall'UNESCO), Polo Scientifico dell'Università di Firenze, 1-12 Maggio 2006.

2003: 1ST PRACTICAL TRAINING COURSE: INNOVATIVE COMBINATORIAL APPROACHES AND TECHNOLOGIES (sponsorizzato dalla European Society of Combinatorial Sciences,) Polo Scientifico dell'Università di Firenze, 9-11 Aprile, 2003.

Inoltre nel periodo 2001-2010 ha contribuito come membro del Comitato scientifico di 4 congressi: nel 2010: 31st European Peptide Symposium, Copenhagen (Danimarca); nel 2009: SCS-09 2nd International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials, Bejing (Cina); 2001, 2002 e 2004 : 2nd, 3rd e 5th Medicinal Chemistry Conference: Drug discovery and Design, University of Patras (Grecia).

Altri titoli

10

Partecipazione a comitati editoriali di riviste Editor-for-Europe di Protein & Peptide Letters, Bentham Science Publishers Ltd. (http://www.bentham.org/).

01/2005 ad oggi

Membro dell'Editorial Advisory Board di Current Drug Delivery, Bentham Science Publishers Ltd. (http://benthamscience.com/cdd/EBM.htm)

01/2004 ad oggi

Membro dell'Editorial Advisory Board del Journal of Peptide Science, Publisher Wiley (http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1009-1387/h omepage/EditorialBoard.html)

01/2009 ad oggi

Membro dell'Editorial Advisory Board dell'International Journal of Peptide Research and Therapeutics, Publisher Springer (www.springer.com/life+sciences/biochemistry+%26+biophysics/journ al/10989?detailsPage=editorialBoard)

01/2003 ad oggi

Membro dell'Editorial Board di Chemistry Today, Editore Teknoscienze (chemistry-today.teknoscienze.com/editoria.ast)

01/2007 ad oggi

PREMI PER L'ATTIVITÀ DI TRASFERIMENTO TECNOLOGICO

2009: PREMIO VESPUCCI attribuito ad Anna Maria Papini per le attività della start-up Toscana Biomarkers. Sezione start-up e honourable mention per le prospettive di sviluppo della company mirate alla ricerca e produzione di metodologie diagnostiche innovative per le malattie autoimmuni quali sclerosi multipla e artrite reumatoide.

2008: PREMIO FROST & SULLIVAN EXCELLENCE IN RESEARCH AWARD IN THE EUROPEAN AUTOIMMUNE DISEASE DIAGNOSTICS MARKET presented to Anna Maria Papini per la start-up Toscana Biomarkers, 19 Marzo 2009, London (UK).

START-CUP 2006 PER IL BUSINESS PLAN D'IMPRESA attribuito dalla Scuola Sant'Anna di Pisa alla futura start-up Toscana Biomarkers Srl (Via Fiorentina 1, Siena) fondata a novembre 2006 e successivamente bioincubata presso Toscana Life Sciences Foundation da Marzo 2007.

2004: PREMIO VESPUCCI RICERCA, INNOVAZIONE, ETICA IN TOSCANA SEZIONE BREVETTI, attribuito dal Consiglio Regionale della Toscana a Firenze l'11 dicembre 2004 ad Anna Maria Papini per il brevetto dell'Università di Firenze "Preparation of glycopeptides for use in the diagnosis or therapeutic treatment of multiple sclerosis". Inventori: A.M. Papini, P. Rovero, M. Chelli, F. Lolli WO 03000733.

Risultati ottenuti nel trasferimento tecnologico in termini di partecipazione alla creazione di nuove imprese, sviluppo, impiego e commercializzazione di brevetti

Anna Maria Papini è co-inventrice di 11 brevetti che dimostrano il suo forte coinvolgimento in attività di trasferimento tecnologico. Infatti, la principale linea di ricerca che ha portato avanti nell'ultimo decennio ha avuto significativi sviluppi in termini di trasferimento tecnologico e valorizzazione dei risultati della ricerca.

In particolare, LA DOMANDA DI BREVETTO INTERNAZIONALE NUMERO 252 DELL'ELENCO DELLE PUBBLICAZIONI scientifiche, sull'uso diagnostico/prognostico nella sclerosi multipla di una famiglia di nuovi glicopeptidi sintetici basati su struttura a beta-turn è stata concessa in Europa, USA, CA, AU e IL. Il brevetto, di proprietà dell'Università di Firenze, è stato oggetto di due importanti contratti di licenza, di cui uno internazionale. UNA SECONDA DOMANDA DI BREVETTO INTERNAZIONALE (NUMERO 235 DELL'ELENCO DELLE PUBBLICAZIONI) sull'uso terapeutico degli stessi glicopeptidi in procedure di aferesi, non è stata ancora valorizzata.

Questa famiglia di brevetti ha portato Anna Maria Papini con gli altri colleghi co-autori, a fondare già nel 2003 LA SOCIETÀ ESPIKEM SRL PRIMA SPIN-OFF DELL'UNIVERSITÀ DI FIRENZE. Questa società, che offre servizi di sintesi su commissione e consulenza nel campo della scienza dei peptidi, ha superato la fase di spin-off ed è tuttora attiva, essendo controllata da investitori privati (www.espikem.com).

Nel 2006, la linea di ricerca sull'uso di peptidi sintetici nella diagnostica in vitro delle malattie autoimmuni ha portato Anna Maria Papini, con altri quattro colleghi delle Università di Firenze e di Pisa, alla fondazione di UNA SECONDA SOCIETÀ SPIN-OFF: TOSCANA BIOMARKERS SRL (www.toscanabiomarkers.com). Quest'azienda è collocata dal 2007 presso il Bio-Incubatore della Regione Toscana a Siena (Fondazione

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Toscana Life Sciences), È STATA FINANZIATA DA INVESTITORI ISTITUZIONALI REGIONALI PER OLTRE 2 MILIONI DI EURO IN SEI ANNI, ha assunto in modo permanente cinque giovani ricercatori ed HA PRODOTTO SEI DOMANDE DI BREVETTO INTERNAZIONALI DELLE QUALI LA PROF. ANNA MARIA PAPINI È CO-AUTRICE e che hanno fatto l'oggetto di contratti di licenza con società diagnostiche italiane ed internazionali, che stanno portando nel 2013 al lancio sul mercato di nuovi prodotti diagnostici in vitro, basati su peptidi sintetici. Toscana Biomarkers Srl ha stipulato, fin dal 2007, un significativo accordo di ricerca con l'Università di Firenze, tutt'ora in vigore. La Prof. Anna Maria Papini è Presidente del Comitato Scientifico di questa società ed in tale veste ha collaborato alla PARTECIPAZIONE A NUMEROSI BANDI COMPETITIVI (REGIONALI, NAZIONALI ED EUROPEI), CHE HANNO PORTATO ALLA SOCIETÀ FINANZIAMENTI PER CIRCA 700.000,00 EURO, con importanti ricadute anche per l'Università di Firenze, partner di molti di questi progetti (si veda il precedente paragrafo su progetti di ricerca finanziati).

Inoltre la collaborazione con il gruppo di ricerca del Prof. Z. Kaminski dell'Università di Lodz (Polonia) ha portato alla messa a punto di NUOVI PROCESSI PER L'OTTENIMENTO DI REATTIVI A BASE TRIAZINICA UTILI NELLE REAZIONI DI COUPLING PER LA SINTESI DI PEPTIDI IN SOLUZIONE E SU FASE SOLIDA, una delle linee di ricerca di Anna Maria Papini. Questi risultati hanno costituito l'oggetto di DUE DOMANDE DI BREVETTO INTERNAZIONALI di cui è coautrice (numeri 185 e 186 DELL'ELENCO DELLE PUBBLICAZIONI) che sono state cedute alla Società ITALVELLUTI S.p.a.

Infine, la linea di ricerca mirata allo sviluppo di PEPTIDI MODIFICATI PER LA DIAGNOSI E LA TERAPIA DI TUMORI CHE ESPRIMONO IL RECETTORE DELLA SOMATOSTATINA ha prodotto ulteriori domande di brevetto di cui Anna Maria Papini è coautrice, licenziata ad un'azienda locale di produzione di intermedi. Inoltre nell’ambito del progetto della Chaire d’Excellence ha recentemente contribuito al brevetto basato su derivati “Click” di coniugati della somatostatina come sonde per cellule tumorali sviluppato nell’ambito della collaborazione tra l’Université de Bourgogne, il CNRS e l’Université de Cergy-Pontoise.

Dalla fondazione del Laboratorio Interdipartimentale di Chimica e Biologia di Peptidi e Proteine, a conferma dell'interesse anche verso attività di trasferimento tecnologico, nel periodo 2001-2012, Anna Maria Papini ha stipulato convenzioni di ricerca nazionali ed internazionali con aziende private quali IMMCO Diagnostics Buffalo, Fresenius Cabi, Merck-Serono, EspiKem, Toscana Biomarkers e altre nonché con istituzioni di ricerca miste pubblico/privato quali l'Istituto Europeo di Oncologia e la Fondazione Bracco per un importo complessivo superiore ai 500.000,00 Euro.

COMUNICAZIONE DELL’ATTIVITA’ SCIENTIFICA NEL PERIODO 1997-2010 LA PRODUZIONE SCIENTIFICA DI ANNA MARIA PAPINI È STATA SELEZIONATA DA REFEREE PER 19 PRESENTAZIONI ORALI (12 PRESENTATE DA LEI) A CONGRESSI INTERNAZIONALI (7 IN PAESI EXTRA-EUROPEI E 12 IN EUROPA) DELLE QUALI 4 EFFETTUATE DA SUOI DOTTORANDI QUALI YOUNG INVESTIGATORS.

Una nel 1997: 15th American Peptide Symposium, Nashville (Tennessee, U.S.A.); 2 nel 1998: 25th European Peptide Symposium, Budapest (Hungary); 10th International Congress of Immunology, New Delhi (India); 1 nel 2000: 26th European Peptide Symposium, Montpellier (France); 2 nel 2002: 27th European Peptide Symposium, Sorrento (Italy); Third Italian-French Meeting on Organic Chemistry. "Organic Chemistry towards Interfaces", Pisa; 2 nel 2003: 18th American Peptide Symposium, Boston, MA, USA (un'orale di A.M. Papini e una Young Investigator presentation di una sua dottoranda); 5 nel 2005: 19th American Peptide Symposium, San Diego, CA, USA, Bert Schram Price for Young Investigators (1 orale di una dottoranda di AM Papini),; EUROCOMBI3, Winchester, U.K.; XVIII International Symposium on Glycoconjugates, Glyco XVIII, Firenze; 18th Polish Peptide Symposium, Wroclaw, Polonia; First European Conference on Chemistry for Life Sciences, Rimini; 3 nel 2006: Chemistry & Biology of Peptides, Gordon Research Conference, Ventura, CA, USA; 1st International Workshop on Expression, Function & Structure of Membrane Proteins, Firenze; 29th European peptide Symposium, Gdansk, Polonia; 1 nel 2007: 7° Australian Peptide Symposium & 2nd Asian Pacific International Peptide Symposium, Cairns, QLA, Australia; 2 nel 2010: 31st European Peptide Symposium (2 orali di dottorandi di AM Papini), Copenhagen (Denmark).

INOLTRE NEL PERIODO 2000-2012 LA PRODUZIONE SCIENTIFICA DI A.M. PAPINI È STATA PRESENTATA CON 119 POSTER A CONGRESSI INTERNAZIONALI (170 POSTER NEL PERIODO 1991-2012).

NEL PERIODO 2009-2012 È STATA INVITATA A PRESENTARE 9 CONFERENZE (2 IN PAESI EXTRAEUROPEI E 7 IN EUROPA) MIRATE AL TRASFERIMENTO TECNOLOGICO NELLO SPAZIO GLOBALE DELLA RICERCA E SVILUPPO NEL SETTORE DELLA CHIMICA.

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In particolare quattro nel 2009 (1 in Giappone: Séminaire de promotion économique du Val d'Oise (Mydome Osaka) : « VAL D'OISE : Nouveaux projets technologiques, nouvelles opportunités de coopérations avec des partenaires japonais » - Mission Economique Académique et Technologique Osaka); 3 in Francia : Presentation of PeptLab Infrastructure to Cosmetic Valley, Neuville; Hybrigenics, Paris; CGVO Semaine de la Recherche et de l'Innovation, Cergy-Pontoise); 2 nel 2010 (Cina: 5th EU-China Business & Technology Cooperation Fair" Biopharmaceutical Forum - EU Project Innovation Centre, Chengdu Sichuan ; Italia: China Italy Regional Cooperation Forum on Technology and Innovation, Firenze) ; 2 nel 2011 (Svizzera : F. Hoffman La Roche, Basel; Francia: 3M France, Val d'Oise Cergy); 1 nel 2012 (1 in Francia: IPSEN Innovation Les Ulis).

CONFERENZE E CONGRESSI NAZIONALI

NEL PERIODO 2002-2011 HA PRESENTATO 13 CONTRIBUTI ORALI E 18 COMUNICAZIONI POSTER A CONGRESSI NAZIONALI IN ITALIA.

QUATTRO PRESENTAZIONI ORALI SELEZIONATE: 2002: XXVIII Convegno Nazionale della Divisione di Chimica Organica della S.C.I., Rome; 2003: XXI Congresso Nazionale della SCI Divisione di Chimica dei Sistemi Biologici, Torino; 2004: Riunione Scientifica Annuale della Società Chimica Italiana Organica, Sezione Toscana; 2006: XXII Congresso Nazionale della Società Chimica Italiana, Firenze.

NOVE PRESENTAZIONI ORALI SU INVITO : 1 nel 2010 (XII Convegno-Scuola sulla Chimica dei Carboidrati, Gruppo Interdivisionale Chimica dei Carboidrati della S.C.I., Pontignano Siena); 1 nel 2007: Istituto di Biofisica, CNR, Pisa; 2 nel 2008: (Istituto Clinico Humanitas, Centro di Ricerca e Didattica, Rozzano; BioInItaly, Milano; 3 nel 2009 (BioInItaly, Milano; Ricerca Impresa, Polo Scientifico e Tecnologico Università di Firenze; Università degli Studi di Pavia - Master di II livello in "Progettazione e Sviluppo di Farmaci" Attualità nella Ricerca Farmaceutica Farmaci peptidici e peptoidici"); 2 nel 2011: Dip.to di Scienze della Vita - Università degli Studi di Trieste ; Università degli Studi di Pavia - Master di II livello in "Progettazione e Sviluppo di Farmaci" Attualità nella Ricerca Farmaceutica Farmaci peptidici e peptoidici").

ATTIVITÀ DI DELEGATO ERASMUS PER LA CHIMICA PER IL SERVIZIO RELAZIONI INTERNAZIONALI DELLA FACOLTÀ DI SMFN DELL'UNIVERSITÀ DI FIRENZE

Da Settembre 2013 Anna Maria Papini svolge la funzione di Coordinatore delle Relazioni Internazionali della Scuola di Scienze Matematiche Fisiche e Naturali dell’Università di Firenze Dal 2006 ad oggi Anna Maria Papini svolge la funzione di Delegato Erasmus per la Chimica per il servizio Relazioni Internazionali su nomina della Scuola di SMFN (http://www.scienze.unifi.it/upload/sub/DELEGATI%20ERASMUS.pdf) e contribuisce a creare numerosi link per il programma Lifelong Learning Programme Erasmus Studio [ad esempio: University of Newcastle upon Tyne (UK), Università di Patrasso (Grecia), Università di Cergy-Pontoise e Ecole Normale Supérieure de Chimie di Montpellier (Francia), Università di Regensburg (Germania), Università di Lodz e Università di Gdansk (Polonia) , Università di Balikesir (Turchia) e per LLP Erasmus Placement [CSCB di Dublino (Irlanda) e con industrie come 4SC AG di Martinsried (Germania), ChemaTech Macrocyle Design Technnologies di Digione (Francia)].

Inoltre nello stesso periodo ha gestito l'organizzazione del Learning agreement per la scelta dei corsi e l'inserimento di 127 studenti stranieri in entrata nel CdL in Chimica e 18 studenti in uscita dall'Università di Firenze. Inoltre ha organizzato gli stage di 24 studenti in uscita dall'Università di Firenze presso laboratori di ricerca universitari o industriali creando i contatti sulla base degli interessi degli studenti per rispondere ai bandi Erasmus Placement e di 5 studenti stranieri in entrata presso i laboratori dei colleghi del Dipartimento.

Sempre nell'ambito del programma LLP Erasmus ha effettuato attività didattica [si veda il paragrafo Attribuzione di incarichi di insegnamento o di ricerca (fellowship) ufficiale presso atenei e istituti di ricerca, esteri e internazionali di alta qualificazione] con Accordi di Mobilità Docenti dell'Università di Firenze negli anni 2010: Università di Balikesir e Bolu (Turchia), Patrasso (Grecia), Gdanszk (Polonia) (AF N° 2009-1-IT2-ERA02-09056)] e 2012: Università di Patrasso (AF N° 2011-1-IT2-ERA02-25889).

PARTECIPAZIONE A COMMISSIONI DI ESAME FINALE DI DOTTORATI ALL'ESTERO E ATTIVITÀ DI TUTORATO DI STAGE DI STUDENTI DI MASTER E DOTTORATO ANCHE CON ERASMUS PLACEMENT ALL'UNIVERSITA' DI FIRENZE.

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MEMBRO DELLE COMMISSIONI DI VALUTAZIONE FINALE DI DOTTORATI DI RICERCA IN SCIENZE CHIMICHE E ABILITAZIONI IN SCIENZE CHIMICHE, SPECIALITÀ CHIMICA ORGANICA ALL'ESTERO

NEL PERIODO 2000-2014 ANNA MARIA PAPINI HA PARTECIPATO A 15 COMMISSIONI DI VALUTAZIONE FINALE DI DOTTORATI ALL'ESTERO.

IN DETTAGLIO: 4 commissioni come Rapporteur (di cui 2 all'Université Pierre et Marie Curie di Parigi, 1 all'Università Montpellier 2 e 1 all'Université de Strasbourg), 5 come Esaminatore (1 Università Paris-Sud, 2 all'Università di Cergy-Pontoise, 1 all’Université Pierre et Marie Curie/Ecole Normale Supérieure, 1 all'Università di Montreal), 3 come Membro Esterno (1 all'Université de Bourgogne, 1 all'Université de Cergy-Pontoise e 1 all'Université de Strasbourg) e 5 come Direttore di tesi in cotutela tra l'Università di Firenze e l'Università di Cergy-Pontoise. Inoltre è stata Rapporteur di 2 Habilitations à diriger les recherches (1 all'Università di Strasburgo e 1 all'Université Pierre et Marie Curie di Parigi). ATTIVITÀ DI TUTORATO DI STAGE DI STUDENTI DI MASTER E DOTTORATO

NEL PERIODO 2001-2014 ANNA MARIA PAPINI HA SVOLTO PRESSO PEPTLAB DEL DIPARTIMENTO DI CHIMICA DELL'UNIVERSITÀ DI FIRENZE ATTIVITÀ DI TUTORATO PER PERIODI VARIABILI DA 4 MESI A 1 ANNO A 19 STUDENTI STRANIERI DI CUI 13 STAGE DI MASTER E 6 STAGE DI DOTTORATO NELL'AMBITO DEL PROGRAMMA LLP ERASMUS PLACEMENT.

IN DETTAGLIO:

STAGE DI MASTER : 1 della Facoltà di Scienze dell'Università di Burgos, 1 della Facoltà di Scienze dell'Università Autonoma di Madrid, 1 dell' Università di Valencia e 1 dell'Universitad del Vais Pasco (Spagna), 1 del Dipartimento di Chimica dell'Università di Patrasso (Grecia), 2 dell'Ecole Nationale Supérieure de Chimie di Montpellier e 2 dell'Université de Cergy-Pontoise (Francia), 1 dell'All India Institute of Immunology (India), 2 dell’Università di Gdansk (Polonia) e 1 dell’Università di Oviedo (Spagna). STAGE DI DOTTORATO: 1 del Dipartimento di Chimica dell'Università di Patrasso (Grecia), 2 del Dipartimento di Chimica della Hebrew University e 1 del Weizmann Institute of Science, Rehovot (Israele), 1 del Laboratory for Organic & Microwave-Assisted Chemistry, KU Leuven (Belgio) e 1 dell'Università di Madrid (Spagna).

TUTORE DI TESI DI DOTTORATO E COTUTELE/CONVENZIONI CON UNIVERSITÀ ESTERE

NEL PERIODO 2000-2014 ANNA MARIA PAPINI È STATA TUTORE DI 16 TESI DI DOTTORATO DELLE QUALI: 13 DELLA SCUOLA DI DOTTORATO IN SCIENZE CHIMICHE DELL’UNIVERSITA’ DI FIRENZE (2 ANCORA IN CORSO) DI CUI 4 CON BORSA DEL MIUR E 9 FINANZIATE SU PROGETTI DI RICERCA; INOLTRE 8 INTERNAZIONALIZZATE ON CONVENZIONI DI COTUTELA. Inoltre da Novembre 2014 è tutore di una tesi di dottorato finanziata dall’ANRT (thèse CIFRE) per la formazione di un dottorato d’interesse industriale.

IN DETTAGLIO:

1 (XVII ciclo) con convenzione con il Max Planck della Biochimica di Martinsried (Germania), 1 (XXII ciclo) con cotutela regolamentata dal progetto FIRB Internazionalizzazione 2007-2009 con la Harvard Medical School, 5 (XIII, XX, XXIV, XXV e XXVII) con cotutela con l'Ecole Doctorale Sciences et Ingénierie n° 417 dell'Universitè de Cergy-Pontoise (Francia), 1 (XXV ciclo) con convenzione con l'Ecole Normale Supérieure di Parigi (Francia) Laboratorie des Biomolécules - Département de Chimie]. 1 (una) della Scuola di Dottorato in Sistemi Complessi e Dinamiche Non Lineari (uno studente indiano); 2 (due) dell'Ecole Doctorale Sciences et Ingénierie n° 417 dell'Universitè de Cergy-Pontoise (Francia) di cui una con convenzione con Novartis Vaccines, Siena.

Gli ex dottorandi si sono collocati professionalmente in posizioni di ricercatore a tempo indeterminato presso startup (3 in Toscana Biomarkers), spin-off (1 in EspiKem) e industrie (2, Novartis e PQE), maitre de conference presso università francesi (1), postdoc presso centri di ricerca in Francia, Germania e USA (1 all'Università di Cergy-Pontoise, 1 al Max Planck Institut fuer Biochemie, all’MIT, Cambridge-Boston, 2 che hanno i requisiti per l'abilitazione a professore associato).

Inoltre Anna Maria Papini è membro del Collegio dei Docenti della Scuola di Dottorato in Scienze Chimiche dell'Università di Firenze. Ha partecipato ad una commissione di concorso di selezione e a più commissioni di esami finali.

Nel periodo 2008-2012 è stata nominata membro esterno di 2 commissioni di tesi della Scuola di Dottorato

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Scienze Chimiche e Farmaceutiche dell'Università di Siena TUTORE DI TESI DI LAUREA

ANNA MARIA PAPINI HA CONTRIBUITO NEL PERIODO 1997-2012 A 46 TESI DI LAUREA, DI CUI 4 NEL PERIODO 1997-2000 E 42 NEL PERIODO 2001-2012 (39 COME RELATORE, 6 COME CORRELATORE E 2 COME CONTRORELATORE). IN DETTAGLIO: TESI DI LAUREA DEL CORSO DI LAUREA IN CHIMICA DELLA FACOLTÀ DI SMFN DELL'UNIVERSITÀ DI FIRENZE.

1997-2007: 12 Tesi di Laurea quinquennale in Chimica Vecchio Ordinamento di cui: 10 come Relatore e 2 (due) come Correlatore.

2006-2012: 11 Tesi di Laurea Specialistica delle quali: 10 in Chimica delle Molecole Biologiche (8 in qualità di Relatore (1 insieme al correlatore Prof. Stefan Oscarson del Centre for Synthesis & Chemical Biology CSCB - di Dublino, Irlanda), 1 come Correlatore e 1 come Controrelatore); 1 come Relatore in Chimica dell'Ambiente e dei Beni Culturali con correlatore la Dr. Laure Menjou del SIAAP di Parigi (Syndicat interdepartemental pour l'assainissement de l'Agglomération Parisienne).

2010-2012: 3 tesi di Laurea Magistrale in Scienze Chimiche delle quali: 2 come Relatore (1 per il Curriculum: Chimica delle Molecole Biologiche e 1 per il Curriculum: Sintesi, struttura e proprietà dei composti organici con correlatore il Dr. Stefano Pegoraro dell'Azienda Farmaceutica 4SC AG di Martinsried, Germania) e 1 come Controrelatore (Curriculum: Chimica dell'Ambiente e dei Beni culturali). 2014-2015: 6 tesi di Laurea Magistrale in Scienze Chimiche in qulità di Relatore di cui una in collaborazione con Novartis Vaccines e due in collaborazione con il Laboratoire de Biomolécules dell’Université Pierre et Marie Curie (Parigi).

2005-2012: 17 tesi di Laurea Triennale in Chimica delle quali: 16 come Relatore (13 per il Curriculum di Scienze Chimiche di cui 1 in collaborazione con il Prof. Stefan Oscarson del "Centre for Synthesis and Chemical Biology, University College Dublin, Irlanda e 1 con il Dr. Alix Toribio di Phycosource, Cergy-Pontoise, Francia nell'ambito del programma Erasmus Placement), 1 per il Curriculum Tecnologie Chimiche e 2 per il Curriculum Tecnologie per la Conservazione e il Restauro dei Beni Culturali) e 1 come Correlatore per il Curriculum Tecnologie per la Conservazione e il Restauro dei Beni Culturali.

2014-2015: 1 tesi di Laurea Triennale in Chimica. TESI DI LAUREA DEL CORSO DI LAUREA IN FARMACIA DELLA FACOLTÀ DI FARMACIA DELL'UNIVERSITÀ DI FIRENZE

2004-2010: Relatore di 2 tesi delle quali: 1 Laurea in Farmacia vecchio ordinamento e 1 Laurea Specialistica in Farmacia. 2012: Correlatore di 1 tesi di Laurea Magistrale in Scienze della Nutrizione della Facoltà di Medicina dell'Università di Firenze. TESI DI LAUREA DEL CORSO DI LAUREA MAGISTRALE IN BIOTECNOLOGIE MOLECOLARI INTERFACOLTÀ DELL'UNIVERSITÀ DI FIRENZE. 2013: Correlatore di 1 tesi in cotutorato con il Prof. J. De Seze dell’Université de Strasbourg-INSERM.

RESPONSABILITÀ SCIENTIFICA DI ASSEGNISTI DI RICERCA E GIOVANI RICERCATORI PRESSO IL DIPARTIMENTO DI CHIMICA DELL'UNIVERSITÀ DI FIRENZE

NEL PERIODO 2001-2014 ANNA MARIA PAPINI È STATA RESPONSABILE SCIENTIFICO DI 13 ASSEGNISTI DI RICERCA (5 ANCORA IN CORSO) PER UN TOTALE DI 54 ANNI DI ASSEGNI COMPRESO 1 ASSEGNO PREMIANTE DELL'UNIVERSITÀ DI FIRENZE E DI 1 GIOVANE RICERCATORE (PER 3 ANNI PROGETTO FIRB RBIN04TWKN, EURO 62.500,00) CHE HANNO SVOLTO LA LORO ATTIVITÀ PER UN TOTALE DI 57 ANNI CON UN COSTO TOTALE DI EURO 1.023.120,00 DI CUI EURO 942.120,00 A CARICO DEI FINANZIAMENTI DI CUI È STATA RESPONSABILE E DI EURO 81.000,00 DI COFINANZIAMENTO A CARICO DELL'UNIVERSITÀ DI FIRENZE.

ATTIVITÀ DIDATTICA DI ANNA MARIA PAPINI ALL'UNIVERSITÀ DI FIRENZE

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2002-2003: Facoltà di SMFN. Titolarità annuale specifica di settore CHIM/06: CdL in Chimica: 1) Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I

2003-2004: Facoltà di SMFN. Titolarità annuale specifica di settore CHIM/06: CdL in Chimica: 1) Insegnamento Chimica Organica IV con Laboratorio di Chimica Organica IV e 2) Insegnamento aggiuntivo Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica.

2004-2005: Facoltà di SMFN. Titolarità annuali specifiche di settore CHIM/06: CdL in Chimica: 1) Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I e 2) Laboratorio di Chimica Biorganica. 3) Insegnamento aggiuntivo CdL specialistica Chimica dell'Ambiente e dei beni culturali Chimica Biorganica.

2005-2006: Facoltà di SMFN. Titolarità annuali specifiche di settore CHIM/06: CdL in Chimica: 1) Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I; 2) Affidamento a titolo gratuito Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I.

2006-2007: Facoltà di SMFN. Titolarità annuale specifica di settore CHIM/06: CdL Specialistica in Chimica delle Molecole Biologiche: 1) Insegnamento Chimica Biorganica e 2) Insegnamento aggiuntivo Laboratorio di Chimica Biorganica; 3) Titolarità annuale specifica di settore CHIM/06: CdL Chimica: Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I.

2007-2008: Facoltà di SMFN. Titolarità annuale specifica di settore CHIM/06: CdL Specialistica in Chimica delle Molecole Biologiche: 1) Insegnamento Chimica Biorganica e 2) Insegnamento aggiuntivo Laboratorio di Chimica Biorganica. Titolarità annuale specifica di settore CHIM/06: CdL Chimica Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I.

2008-2009: Facoltà di SMFN. Titolarità annuali specifiche di settore CHIM/06: 1) CdL in Chimica: Insegnamento Chimica Organica I + Laboratorio di Chimica Organica I Modulo Laboratorio di Chimica Organica I e 2) CdL Specialistica in Chimica delle Molecole Biologiche: Insegnamento Chimica Biorganica; 3) CdL Specialistica in Chimica delle Molecole Biologiche: Insegnamento aggiuntivo Laboratorio di Chimica Biorganica.

2009-2010: Facoltà di SMFN. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica Biorganica. Titolarità annuali specifiche di settore CHIM/06: Laurea in Scienze e Tecnologie Chimiche: Chimica delle Biomolecole.

2010-2011. Facoltà di SMFN. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica Biorganica. Titolarità annuali specifiche di settore CHIM/06: Laurea in Scienze e Tecnologie Chimiche: Chimica delle Biomolecole.

2011-2012: Facoltà di SMFN. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica Biorganica. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica delle Biomolecole. 2012-2013: Scuola di SMFN. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica Biorganica. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica delle Biomolecole.

2013-2014: Scuola di SMFN. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica Biorganica. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica delle Biomolecole. 2014-2015: Scuola di SMFN. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica Biorganica. Titolarità annuali specifiche di settore CHIM/06: Laurea magistrale in Scienze Chimiche: Chimica delle Biomolecole.

ATTIVITA' DIDATTICA INNOVATIVA PRESSO L'UNIVERSITA' DI FIRENZE Corsi di Perfezionamento

16

Nel 2011 e 2012 organizza ed è Direttore del Corso di Perfezionamento annuale alla Professione di Chimico in collaborazione con il Dipartimento di Chimica "Ugo Schiff", la Facoltà di SMFN e l'Ordine dei Chimici della Toscana per favorire l'inserimento di giovani chimici nel mondo del lavoro.

Divulgazione scientifica: progetto OpenLab

Dal 2001 Anna Maria Papini è una delle anime del Progetto OpenLab dell'Università di Firenze (www.openlab.unifi.it/CMpro-v-p-331.html), un innovativo servizio di divulgazione e diffusione della cultura scientifica dell'area della comunicazione avente la missione di promuovere le scienze nella società e particolarmente nelle scuole di ogni ordine e grado. Organizza le attività della Chimica in collaborazione con i colleghi Fisici, il Presidente Prof. R. Casalbuoni e la Dr. C. Gambi e con il gruppo OpenLab costituito da circa 100 tra dottorandi, borsisti e assegnisti di ricerca che effettuano le esperienze sul campo con gli studenti e i docenti delle scuole.

Dal 2006 al 2013 presta la sua opera come vice-presidente di OpenLab rappresentando la chimica nel Consiglio Direttivo e partecipando attivamente all'organizzazione di Manifestazioni quali ScienzEstate, il Pianeta Galileo, percorsi scientifici di chimica nelle biblioteche ed altre.

Prof. Anna Maria Papini, PhD

List of the scientific peer-reviewed articles in journals (Period 2004-2014)

2004

[40] M.C. Alcaro, G. Sabatino, J. Uziel, M. Chelli, M. Ginanneschi, P. Rovero, and A.M. Papini . On-resin head-to-tail cyclization of cyclotetrapeptides: optimization of crucial parameters. J. Peptide Science (2004) 10, 218-228. [41] F. Meyer, A. Laaziri, A.M. Papini , J. Uziel, and S. Jugé. A novel phosphorus-carbon bond formation by ring opening with diethyl phosphite of oxazolines derived from serine. Tedrahedron (2004) 60, 3593-3597. [42] F. Machetti, F.M. Cordero, F. De Sarlo, A.M. Papini , M.C. Alcaro, and A. Brandi. Synthesis of free and Nα -Fmoc/Nα-Boc protected (2S, 4S)- and (2S, 4R)-4-aminopipecolic acids. Eur. J. Org. Chem. (2004) 13, 2928-2935. [43] A. Innocenti, A. Casini, M.C. Alcaro, A.M. Papini, A. Scozzafava, and C.T. Supuran. Carbonic anhydrase inhibitors: The first on-resin screening of a 4-sulfamoylphenylthioureas library. J. Med. Chem. (2004) 47, 5224-5229. [44] G. Caminati, E. Peroni, A.M. Papini , and P. Baglioni. Photophysical investigation of lipopeptides of myelin basic protein in phospholipid vesicles. Progress in Colloid & Polymer Science (2004) 126, 163-168. [45] G. Sabatino, M. Chelli, A. Brandi, and A.M. Papini . Analytical methods for solid phase peptide synthesis. Current Organic Chemistry (2004) 8, 291-301.

2005 [46] A. Carotenuto, D. D’Addona, E. Rivalta, M. Chelli, A.M. Papini , P. Rovero, and M. Ginanneschi. Synthesis of a dicarba-analogue of octreotide keeping the type II’ β-turn of the pharmacophore in water solution. Lett. Org. Chem. (2005) 2, 274-279. [47] J. Matsoukas, V. Apostolopoulos, H. Kalbacher, A.M. Papini , T. Tselios, K. Chatzantoni, T. Biagioli, F. Lolli, S. Deraos, P. Papathanassopoulos, A. Troganis, E. Mantzourani, T. Mavromoustakos, and A. Mouzaki. Design and synthesis of a novel potent myelin basic protein epitope 87-99 cyclic analogue: enhanced stability and biological properties of mimics render them a potentially new class of immunomodulators. J. Med. Chem. (2005) 48, 1470-1480. [48] F. Nuti, S. Hildenbrand, M. Chelli, R. Wodarzb, and A.M. Papini . Synthesis of DEHP metabolites as biomarkers for GC-MS evaluation of phthalates as endocrine disrupters. Bioorg. Med. Chem. (2005) 13, 3461-3465. [49] A.M. Papini. Simple test for Multiple Sclerosis, Nature Medicine (2005) 11(1), 13.

[50] F. Lolli, B. Mulinacci, A. Carotenuto, B. Bonetti, G. Sabatino, B. Mazzanti, A.M. D’Ursi, E. Novellino, M. Pazzagli, L. Lovato, M.C. Alcaro, E. Peroni, M.C. Pozo-Carrero, F. Nuti, L. Battistini, G. Borsellino, M. Chelli, P. Rovero, and A.M. Papini . An N-glucosylated peptide detecting disease-specific autoantibodies, biomarkers of Multiple Sclerosis. Proc. Natl. Acad. Sci., U.S.A. (2005) 102(29), 10273-10278. [51] F. Lolli, B. Mazzanti, M. Pazzagli, E. Peroni, M.C. Alcaro, R. Lanzillo, V. Brescia Morra, L. Santoro, C. Gasperini, S. Galgani, M.M. D’ Elios, V. Zipoli, S. Sotgiu, M. Pugliatti, P. Rovero, M. Chelli, and A.M. Papini . The glycopeptide CSF114(Glc) detects serum antibodies in Multiple Sclerosis. J. Neuroimmunol. (2005) 167(1-2), 131-137. [52] S. Giannecchini, M.C. Alcaro, P. Isola, O. Sichi, M. Pistello, A.M. Papini , P. Rovero, and M. Bendinelli. Feline immunodeficiency virus plasma load reduction by a retroinverso octapeptide reproducing the Trp-rich motif of the transmembrane glycoprotein. Antiviral Therapy (2005) 10, 671-680. [53] F. Lolli, P. Rovero, M. Chelli, and A.M. Papini . Antibodies against glycosylated native MOG are elevated in patients with Multiple Sclerosis. Neurology (2005) 65(5), 781-782. [54] Z.J. Kaminski, B. Kolesinska, J. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, M. Baszczyk, M.L. Gowka, and A.M. Papini . N-triazinylammonium tetrafluoroborates. A new generation of efficient coupling reagents useful for peptide synthesis. J. Am. Chem. Soc. (2005), 127,16912-16920.

2006 [55] F. Minutolo, S. Bertini, L. Betti, R. Danesi, G. Gervasi, G. Giannaccini, A. Martinelli, A.M. Papini, E. Peroni, G. Placanica, S. Rapposelli, T. Tuccinardi, and M. Macchia. Synthesis of stable snalogues of geranylgeranyl Diphosphate possessing a (Z,E,E)-geranylgeranyl side chain, docking analysis, and biological assays for prenyl protein transferase inhibition. Chem. Med. Chem. (2006) 1, 218-224. [56] A.M. D’Ursi, S. Giannecchini, C. Esposito, M.C. Alcaro, O. Sichi, M.R. Armenante, A. Carotenuto, A.M. Papini , M. Bendinelli, and P. Rovero. Development of antiviral fusion inhibitors: short modified peptides derived from the transmembrane glycoprotein of feline immunodeficiency virus. Chem. Biochem. (2006) 7, 774-779. [57] M.C. Alcaro, V. Vinci, A.M. D’Ursi, M. Scrima, M. Chelli, S. Giuliani, S. Meini, M. Di Giacomo, L. Colombo, and A.M. Papini . Bradykinin antagonists modified with dipeptide mimetic β-turn inducers. Bioorg. Med. Chem. Lett. (2006) 16, 2387-2390. [58] M.C. Alcaro, and A.M. Papini . Contribution of peptides to Multiple Sclerosis research. Biopolymers: Peptide Science (2006) 84, 349-367. [59] V.V. Volkov, F. Nuti, Y. Takaoka, R. Chelli, A.M. Papini , and R. Righini. Hydration and hydrogen bonding of carbonyls in dimyristoyl-phospahtidylcholine bilayer. J. Am. Chem. Soc. (2006) 128, 9466-9471. [60] A. Carotenuto, A.M. D’Ursi, B. Mulinacci, I. Paolini, F. Lolli, A.M. Papini , E. Novellino, and P. Rovero. Conformation-activity relationship of designed glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. J. Med. Chem. (2006) 49, 5072-5079.

[61] F. Lolli, P. Rovero, M. Chelli, and A.M. Papini . Toward biomarkers in multiple sclerosis: new advances. Expert Rev. Neurotherapeutics (2006) 6, 781-794.

2007 [62] F. Rizzolo, G. Sabatino, M. Chelli, P. Rovero, and A.M. Papini. A convenient microwave-enhanced solid-phase synthesis of difficult peptide sequences: case study of Gramicidin A and CSF114(Glc). Int. J. Pept. Res.Ther. (2007) 13, 1-2, 203-208. [63] K. Jastrząbek, B. Kolesińska, G. Sabatino, F. Rizzolo, A.M. Papini, and Z.J. Kamiński. Benzyloxy derivatives of triazine-based coupling reagents designed for an efficient solid phase peptide synthesis on polystyrene resin. Int. J. Pept. Res. Ther. (2007) 13, 1-2, 229-236. [64] B. Kolesińska, J. Frączyk, G. Sabatino, A.M. Papini , and Z.J. Kamiński. Sulfonates of N-triazinylammonium salts as highly efficient, inexpensive and environmentally friendly coupling reagents for peptide synthesis. Chemistry Today (2007) 25(1), 10-13. [65] I. Paolini, F. Nuti, M.C. Pozo-Carrero, F. Barbetti, B. Kolesinska, Z.J. Kaminski, M. Chelli, and A.M. Papini . A convenient microwave-assisted synthesis of N-glycosyl amino acids. Tetrahedron Letters (2007) 48, 2901-2904. [66] F. Nuti, I. Paolini, F. Cardona, M. Chelli, F. Lolli, A. Brandi, A. Goti, P. Rovero, and A.M. Papini. Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides. Bioorg. Med. Chem. (2007) 15, 3965-3973. [67] M.C. Alcaro, F. Lolli, P. Migliorini, M. Chelli, P. Rovero, and A.M. Papini . Peptides as autoimmune diseases antigenic probes: a peptide-based reverse approach to detect biomarkers of autoimmune diseases. Chemistry Today (2007) 25(3), 14-16. [68] V.V. Volkov, R. Chelli, W. Zhuang, F. Nuti, Y. Takaoka, A.M. Papini , S. Mukamel, and R. Righini. Electrostatic interactions in phospholipid membranes revealed by coherent two-dimensional infrared spectroscopy. Proc. Natl. Acad. Sci., U.S.A. (2007) 104, 15323-15327.

2008 [69] D. D’Addona, A. Carotenuto, E. Novellino, V. Piccand, J.C. Reubi, A. Di Cianni, F. Gori, A.M. Papini , and M. Ginanneschi. Novel sst5-Selective Somatostatin Dicarba-Analogues: Synthesis and Conformation-Affinity Relationships. J. Med. Chem. (2008) 51(3), 512-520. [70] F. Real Fernández, A. Chamois-Colson, J. Bayardon, F. Nuti, E. Peroni, R. Meunier-Prest, F. Lolli, M. Chelli, C. Darcel, S. Jugè, and A.M. Papini . Ferrocenyl Glycopeptides as Electrochemical Probes to Detect Autoantibodies in Multiple Sclerosis Patients’ Sera Biopolymers (Peptide Science) (2008) 90(4), 488-495. [71] S. Cantel, A. Le Chevalier-Isaad, M. Scrima, J.J. Levy, R.D. DiMarchi, P. Rovero, J.A. Halperin, A.M. D'Ursi, A.M. Papini , and M. Chorev. Synthesis and Conformational Analysis of a Cyclic Peptide Obtained via i-to-i+4 Intramolecular Side-Chain-to-Side-Chain Azide–Alkyne 1,3-Dipolar Cycloaddition. J. Org. Chem. (2008) 73, 5663-5674. Feautured article and cover.

[72] I. Paolini, F. Rizzolo, and A.M. Papini . Optimized strategies for the synthesis of biomolecules by the microwave approach. Supplement to Chimica Oggi/CHEMISTRY TODAY (2008) 26(3), 16-18. [73] A. Carotenuto, M.C. Alcaro, M.R. Saviello, E. Peroni, F. Nuti, A.M. Papini, E. Novellino, and P. Rovero. Designed glycopeptides with different β-turn types as synthetic probes for the detection of autoantibodies, biomarkers of Multiple Sclerosis. J. Med. Chem. (2008) 51, 5304-5309. [74] A. Le Chevalier Isaad, F. Barbetti, P. Rovero, A.M. D’Ursi, M. Chelli, M. Chorev, and A.M. Papini. N(alpha)-Fmoc-Protected omega-Azido and omega-Ynoic-alpha-Amino Acids as Building Blocks for the Synthesis of "Clickable" Peptides. Eur. J. Org. Chem. (2008) 5308-5314. [75] G. Sabatino, and A.M. Papini . Advances in automatic, manual and microwave-assisted solid-phase peptide synthesis Current Opinion in Drug Discovery & Development (2008) 11(6), 762-768.

2009 [76] S. Carganico, P. Rovero, J. A. Halperin, A.M. Papini , and M. Chorev Building Blocks for the Synthesis of Post-Translationally Modified Glycated Peptides and Proteins. J. Pept. Sci. (2009) 15, 67-71. [77] M.C. Alcaro, I. Paolini, F. Lolli, P. Migliorini, P. Rovero, A.M. Papini . Peptide contribution to the diagnosis of autoimmune diseases. Chimica Oggi/CHEMISTRY TODAY (2009), 27, 2, 11-14. [78] A.M. Papini Towards peptide-based diagnostics. Chimica Oggi/CHEMISTRY TODAY (2009), 27, 2, 2. [79] M. Angeles Bonache, F. Nuti, A. Le Chevalier Isaad, F. Real-Fernandez, M. Chelli, P. Rovero, and A.M. Papini. Synthesis of new ribosylated Asn building blocks as useful tools for glycopeptide and glycoprotein synthesis. Tetrahedron Letters (2009) 50, 4151-4153. [80] A. Le Chevalier-Isaad, A.M. Papini, M. Chorev, and P. Rovero. Side chain-to-side chain cyclization by click reaction. Peptide Protocol Paper. J. Pept. Sci. (2009), 15, 451-454. [81] A.M. Papini . The use of post-translationally modified peptides for detection of biomarkers of immune-mediated diseases. J. Pept. Sci. (2009), 15, 621-628. [82] M.A Bonache, A. Le Chevalier, F. Nuti, E. Peroni, M. Chelli, P. Rovero, and A.M. Papini . Ribose building block for the synthesis of glycopeptides for fishing out antibodies in autoimmune diseases. Adv. Exp. Med. Biol. (2009) 611:441-2.

2010 [82] M. Scrima, A. Le Chevalier-Isaad, P. Rovero, A.M. Papini , M. Chorev, and A.M. D'Ursi. CuI-Catalyzed Azide–Alkyne Intramolecular i-to-(i+4) Side-Chain-to-Side-Chain Cyclization Promotes the Formation of Helix-Like Secondary Structures.Eur. J. Org. Chem. (2010), 446-457.

[83] F. Real-Fernández, F. Nuti, M.A. Bonache, M. Boccalini, S. Chimichi, M. Chelli, and A.M. Papini. Microwave-assisted reaction of glycosylamine with aspartic acid. Amino Acids (2010) 39, 599-604

[84] M. Frediani, D. Sémeril, D. Matt, F. Rizzolo, A.M. Papini, P. Frediani and L. Rosi. Ring Opening Polymerization of rac-Lactide using a calix[4]arene-based Titanium (IV) Complex. International Journal of Polymer Science (2010), 1-6. [85] M. Frediani, D. Sémeril, D. Matt, F. Rizzolo, A.M. Papini, P. Frediani, L. Rosi, M. Santella, G. Giachi. L-Lactide Polymerization by Calix[4]arene-Titanium (IV) Complex Using Conventional Heating and Microwave Irradiation. e-Polymers (2010) 19, 1-8. [86] F. Nuti, E. Peroni, F. Real-Fernández, M.A. Bonache, A. Le Chevalier-Isaad, M. Chelli, N. Lubin-Germain, J. Uziel, P. Rovero, F. Lolli, and A.M. Papini. Post-translationally modified peptides efficiently mimicking neo-antigens: a challenge for theragnostics of autoimmune diseases. Biopolymers: Peptide Science (2010) 94, 6, 791-799. [87] A. Di Cianni, A. Carotenuto, D. Brancaccio, E. Novellino, J.C. Reubi, K. Beetschen, A.M. Papini, M. Ginanneschi. Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J. Med. Chem. (2010) 53, 16, 6188-6197. [88] A.M. Papini. Cosmetics toward peptide-based cosmeceutics. Chimica Oggi/CHEMISTRY TODAY (2010) 28, 6, 3-4.

2011 [89] F. Gori, B. Mulinacci, L. Massai, C. Avolio, M. Caragnano, E. Peroni, S. Lori, M. Chelli, A.M. Papini, P. Rovero, F. Lolli. IgG and IgM antibodies to the refolded MOG(1-125) extracellular domain in humans. J. Neuroimmunol. (2011) 233, 216-220. ISSN: 0165-5728, doi: 10.1016/j.jneuroim.2010.11.011 [90] F. Rizzolo, C. Testa, D. Lambardi, M. Chorev, M. Chelli, P. Rovero, A.M. Papini . Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1–34)NH2. J.Pept. Sci. (2011) 17, 708-714. ISSN: 1075-2617, doi: 10.1002/psc.1395 [91] A.M. Papini. Peptide chemistry revolution. Chimica Oggi/CHEMISTRY TODAY (2011) 29, 5, 29-30. ISSN: 0392-839X [92] C. Selmi, A.M. Papini, P. Pugliese, M.C. Alcaro, M.E. Gershwin. Environmental pathways to autoimmune diseases: the cases of primary biliary cirrhosis and multiple sclerosis, Archives of Medical Science (2011), 7, 368-380. ISSN: 1734-1922, doi: 10.5114/aoms.2011.23398

2012 [93] C. Testa, F. Nuti, J. Hayek, C. De Felice, M. Chelli, P. Rovero, G. Latini, and A.M. Papini. Di(2-ethylhexyl)phthalate and Autism Spectrum Disorders. ASN NEURO (American Society for Neurochemistry) (2012) 4(4), 223-229 (Open Access http://creativecommons.org/licenses/by-nc/2.5; art:e00089.doi:10.1042/AN20120015). [3.833] [94] F. Real-Fernández, I. Passalacqua, E. Peroni, M. Chelli, F. Lolli, A.M. Papini, and P. Rovero. Glycopeptide-based antibody detection in Multiple Sclerosis by surface plasmon resonance. Sensors (2012), 12, 5596-5607; doi:10.3390/s120505596. ISSN 1424-8220 (Open Access). [95] M. Scrima, M. Grimaldi, S. Di Marino, C. Testa, P. Rovero, A.M. Papini, M. Chorev, and

A.M. D'Ursi. Solvent independent conformational propensities of [1,2,3]Triazolyl-bridged PTHrP-

derived cyclo-nonapeptide analogues. Biopolymers: Peptide Science (2012) 98, 535–545. ISSN: 1097-0282, doi: 10.1002/bip.22139. [96] C. Guardiani, G.F. Signorini, R. Livi, A.M. Papini, and P. Procacci, P. Conformational Landscape of N-Glycosylated Peptides Detecting Autoantibodies in Multiple Sclerosis, Revealed by Hamiltonian Replica Exchange. JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL (2012), 116, 5458-5467. doi: 10.1021/jp301442n [97] Pandey, S.; Alcaro, M.C.; Scrima, M.; Peroni, E.; Paolini, I.; Di Marino, S.; Barbetti, F.; Carotenuto, A.; Novellino, E.; Papini, A.M.; D'Ursi, A.M.; and Rovero P. Designed glycopeptides mimetics of myelin protein epitopes as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. J.Med.Chem. (2012) Dec 13;55(23):10437-47. doi: 10.1021/jm301031r. Epub 2012 Dec 3.

2013 [98] Pandey, S.; Dioni, I.; Lambardi, D.; Real-Fernandez, F.; Peroni, E.; Pacini, G.; Lolli, F.; Seraglia, R.; Papini, A.M. and Rovero P. Alpha actinin is specifically recognized by multiple sclerosis autoantibodies isolated using an N-glucosylated peptide epitope. Mol Cell Proteomics. (2013) Feb;12(2):277-82. doi: 10.1074/mcp.M112.017087. Epub 2012 Nov 8. [99] Potenza, M.; Sabatino, G.; Giambi, F.; Rosi, L.; Papini, A.M. and Dei, L. Analysis of egg-based model wall paintings by use of an innovative combined dot-ELISA and UPLC-based approach. Analytical & Bioanalytical Chemistry (2013) 405, 691-701. PRINT ISSN 1618-2642, Online ISSN 1618-265, 10.1007/s00216-012-6049-9. [IF 3.841]. [100] Chanson J-B., Paolini I., Collongues N., Alcaro M.C., Blanca F., Barbetti F., Fleurya M., Peroni E., Rovero P., Rudolf G., Lolli F., Trifilieff E., Papini A.M., de Seze J., "Evaluation of new immunological targets in neuromyelitis optica", J. Pept. Sci. (2013) Jan;19(1):25-32. doi: 10.1002/psc.2470. Epub 2012 Nov 28. PMID: 23193094 [PubMed - indexed for MEDLINE]. [101] Friligou, I., Rizzolo, F., Nuti, F., Tselios, T., Evangelidou, M., Emmanouil, M., Karamita, M., Matsoukas, J., Chelli, M., Rovero, P., and Papini, A.M. Divergent and convergent synthesis of polymannosylated dibranched antigenic peptide of the immunodominant epitope MBP(83-99). Bioorg. Med. Chem. (2013) Nov. 1, 21(21), 6718-6725.doi: 10.1016/j.bmc.2013.08.008. Epub 2013 Aug 13. PMID: 23993671 [PubMed - in process]. [102] Candelaresi M, Ragnoni E, Cappelli C, Corozzi A, Lima M, Monti S, Mennucci B, Nuti F, Papini AM, Foggi P. Conformational Analysis of Gly-Ala-NHMe in D(2)O and DMSO Solutions: A Two-Dimensional Infrared Spectroscopy Study. J Phys Chem B. (2013) Nov 21;117(46):14226-14237. doi: 10.1021/jp406139t. Epub 2013 Nov 8. PMID: 24164089 [PubMed – in progress]

2014

[103] Naegeli, A., Neupert, C., Fan, Y-Y, Chia-Wei Lin, C-W, Poljak, K., Papini, A.M., Schwarz, F., and Aebi, M. Molecular analysis of an alternative N-glycosylation machinery by functional transfer from Actinobacillus pleuropneumoniae to Escherichia coli. J Biol Chem. (2014) Jan 24;289(4):2170-2179. doi: 10.1074/jbc.M113.524462. Epub 2013 Nov 25.

[104] Pratesi A, Gabbiani C, Michelucci E, Ginanneschi M, Papini AM, Rubbiani R, Ott I, Messori L. Insights on the mechanism of thioredoxin reductase inhibition by Gold N-heterocyclic carbene compounds using the synthetic linear Selenocysteine containing C-terminal peptide hTrxR(488-499): An ESI-MS investigation. J Inorg Biochem. (2014) 136, 161-169. Epub 2014 Jan 21. pii: S0162-0134(14)00013-0. doi: 10.1016/j.jinorgbio.2014.01.009. [Epub ahead of print]. [105] C. Gellini, G. Sabatino, A.M. Papini, M. Muniz-Miranda. SERS study of a tetrapeptide based on histidine and glycine residues, adsorbed on copper/silver colloidal nanoparticles. J. Raman Spectrosc. (2014), 45(6), 418-423. Article first published online: 8 May 2014. doi: 10.1002/jrs.4484 [106] M. Di Pisa, P. Buccato, G. Sabatino, F. Real Fernández, B. Berti, F. Cocola, A.M. Papini, P. Rovero. Epitope Mapping of the N-terminal Portion of Tissue Transglutaminase Protein Antigen to Identify Linear Epitopes in Celiac Disease. J.Pept:Sci. (2014) 20(9), 689-695. Epub 2014 May 15. doi: 10.1002/psc.2650. [Epub ahead of print]. [107] A.M. Papini, F. Nuti, F. Real-Fernandez, G. Rossi, C. Tiberi, G. Sabatino, S. Pandey, S. Leoncini, C. Signorini, A. Pecorelli, R. Guerranti, S. Lavielle, L. Ciccoli, P. Rovero, C. De Felice, J. Hayek. Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction. J.Immunol.Res. In press (http://www.hindawi.com/journals/jir/raa/260973/). Accepted 15 September 2014. Volume 2014 (2014), Article ID 260973, 6 pages. http://dx.doi.org/10.1155/2014/260973 [108] N. Auberger, M. Di Pisa, M. Larregola, G. Chassaing, E. Peroni, S. Lavielle, A.M. Papini, O. Lequin, J.M. Mallet. Glaser Oxidative Coupling on Peptides: Stabilization of β-Turn Structure via a 1,3-Butadiyne Constraint. Bioorg. Med. Chem. In press. Doi: 10.1016/j.bmc.2014.10.026. [109] B. Kolesinska, K.K. Rozniakowski, J. Fraczyk, I. Relich, A.M. Papini, and Z.J. Kaminski. The Effect of Counter-ion and Tertiary Amine on the Efficiency of N-Triazinylammonium Sulfonates in Solution and Solid-Phase Peptide Synthesis. Eur.J.O.C. in press. Accepted October-3-2014. [110] C. Testa, M. Scrima, M. Grimaldi, A.M. D’Ursi, M.L. Dirain, N. Lubin-Germain, A. Singh, C. Haskell-Luevano, M. Chorev, P. Rovero, A.M. Papini . 1,4-Disubstituted-[1,2,3]triazolyl-Containing Analogues of MT-II: 2 Design, Synthesis, Conformational Analysis, and Biological Activity. J.Med.Chem. (2014) dx.doi.org/10.1021/jm501027w. Publication Date (Web): October 27, 2014. [111] E. Peroni, F. Real Fernández, C. Gheri, F. Nuti, A.-C. Mitaine-Offer, M.A. Lacaille-Dubois, A.M. Papini . Glycosylated natural triterpene saponins for antibody recognition. Phytomedicine in press. [112] C. Rentier, G. Pacini, F. Nuti, E. Peroni, P. Rovero, and A.M. Papini. Synthesis of diastereomerically pure lipoyl-lysine building-blocks for Fmoc/tBu solid phase synthesis of modified peptides designed for primary biliary cirrhosis diagnostics. J.Pept.Sci. Submitted [113] A. Pratesi, M. Ginanneschi, F. Melani, M. Chinol, A. Carollo, G. Paganelli, M. Lumini, M. Bartoli, M. Frediani, L. Rosi, G. Petrucci, L. Messori, and A.M. Papini. Design and Synthesis of New DOTA Conjugated (+)-Biotin Dimers to Develop High Affinity in Vitro Tumor Pretargeting Based on MW-Tuned Avidin Oligomers. J.Med.Chem. Submitted.

[114] M. Di Pisa, S. Pascarella, M. Scrima, G. Sabatino, F. Real Fernández, M. Chelli, D. Renzi, A. Calabrò, A.M. D'Ursi, A.M. Papini, P. Rovero. Synthetic Peptides Reproducing Tissue Transglutaminase-Gliadin Complex Neo-epitopes as Probes for Antibody Detection in Celiac Disease Patients’ Sera. J.Med.Chem. Submitted jm-2014-017126.

Peer-reviewed articles published in books (Period 2004-2014)

2004 [100] M.C. Alcaro, P. Campiglia, P. Grieco, E. Novellino, M. Chelli, and A.M. Papini . An efficient microwave-assisted synthesis of 2,5-diketopiperazines libraries. In: Peptide Revolution: Genomics, Proteomics & Therapeutics. M. Chorev & T.K. Sawyer (Eds), American Peptide Society, San Diego, CA, USA (2004) pp. 17-18. [101] G. Sabatino, M.C. Alcaro, M.C. Pozo-Carrero, M. Chelli, P. Rovero, and A.M. Papini . Assessment of 6Cl-HOBt-based coupling reagents in solid-phase cyclopeptide synthesis. In: Peptide Revolution: Genomics, Proteomics & Therapeutics. M. Chorev & T.K. Sawyer (Eds), American Peptide Society, San Diego, USA (2004) pp. 49-50. [102] E. Peroni, F. Lolli, B. Mazzanti, M. Pazzagli, B. Bonetti, J. Hoebeke, M. Chelli, P. Rovero, and A.M. Papini . Isolation and characterization of autoantibodies in Multiple Sclerosis patients sera: towards a novel apheresis treatment. In: Peptide Revolution: Genomics, Proteomics & Therapeutics. M. Chorev & T.K. Sawyer (Eds), American Peptide Society, San Diego, CA, USA (2004), pp. 75-76. [103] F. Nuti, I. Paolini, B. Mulinacci, M.C. Pozo-Carrero, B. Mazzanti, M. Pazzagli, F. Lolli, M. Chelli, F.M. Cordero, A. Brandi, and A.M. Papini . Small focused library of CSF114-type glycopeptides for the characterization of autoantibody recognition in Multiple Sclerosis, In: Peptide Revolution: Genomics, Proteomics & Therapeutics. M. Chorev & T.K. Sawyer (Eds), American Peptide Society, San Diego, CA, USA (2004) pp. 77-78. [104] A.M. Papini, B. Mulinacci, A. Carotenuto, B. Bonetti, G. Sabatino, E. Peroni, F. Nuti, M.C. Alcaro, M.C. Pozo-Carrero, B. Mazzanti, M. Pazzagli, L. Massacesi, L. Battistini, M. Chelli, P. Rovero, and F. Lolli. MS PepKit: the first diagnostic test to follow-up Multiple Sclerosis. In: Peptide Revolution: Genomics, Proteomics & Therapeutics. M. Chorev & T.K. Sawyer (Eds), American Peptide Society, San Diego, CA, USA (2004) pp. 942-944. [105] B. Mulinacci, F. Nuti, G. Sabatino, M. Chelli, A. Carotenuto, P. Rovero, B. Mazzanti, M. Pazzagli, F. Lolli, and A.M. Papini . Structure-activity relationship study of glycopeptide antigens recognizing specific autoantibodies in Multiple Sclerosis. In: Peptide Revolution: Genomics, Proteomics & Therapeutics. M. Chorev & T.K. Sawyer (Eds), American Peptide Society, San Diego, CA, USA (2004) pp. 1007-1008.

2005 [106] D. D’Addona, M. Chelli, A.M. Papini , A. Carotenuto, F. Budelli, and M. Ginanneschi. Synthesis of a new dicarba-analogue of the drug octreotide. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 202-203.

[107] B. Kolesinska, G. Sabatino, J. Kolesinska, M. Chelli, P. Rovero, Z. Kaminski, and A.M. Papini. ACP solid phase synthesis by new efficient TBCRs. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 232-233. [108] A.M. Papini , B. Kolesinska, G. Sabatino, J. Kolesinska, and Z. Kaminski. Triazine-based coupling reagents useful tools for SPPS. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 252-253. [109] M. de la Cruz Pozo-Carrero, B. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, Z. Kaminski, and A.M. Papini . An efficient strategy for attachment of Fmoc-amino acids to resins by TBCRs. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 257-258. [110] G. Sabatino, B. Kolesinska, M. Chelli, P. Rovero, Z. Kaminski, and A.M. Papini . Automatic SPPS by the new generation of TBCRs. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 263-264. [111] K. Jastrzabek, B. Kolesinska, M. Blaszczyk, M.L. Glòwka, A.M. Papini , and Z. Kaminski. 2-Chloro-4,6-dibenzyloxy-1,3,5-triazine and N-(4,6-dibenzyloxy-1,3,5-triazinyl-2)ammonium tetrafluoroborates as highly efficient coupling reagents for peptide synthesis in solution. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 335-336. [112] J. Kolesinska, B. Kolesinska, A.M. Papini , and Z. Kaminski. Tetrafluoroborates of N-triazinylammonium salts as highly efficient coupling reagents for peptide synthesis in solution. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 337-338. [113] M.C. Alcaro, E. Naldini, B. Mulinacci, B. Mazzanti, M. Pazzagli, E. Peroni, M. Chelli, P. Rovero, and A.M. Papini . Identification of new autoantigens in Multiple Sclerosis by glycopeptide libraries. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 374-375. [114] B. Mulinacci, I. Paolini, A. Carotenuto, B. Mazzanti, M. Pazzagli, M. Chelli, F. Lolli, P. Rovero, and A.M. Papini . β-Hairpin glycopeptides as mimetic autoantigens in multiple sclerosis. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 593-594. [115] I. Paolini, F. Nuti, B. Kolesinska, F. Cardona, M. Chelli, A. Brandi, and A.M. Papini . New glycosylated building-blocks useful for glycopeptide synthesis. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 597-598. [116] E. Peroni, F. Peri, F. Nuti, M. Chelli, and A.M. Papini . Synthetic strategies for forming the glycan-peptide linkage. In: Peptides 2004. Bridges Between Disciplines. M. Flegel, M. Fridkin, C. Gilon, J. Slaninova (Eds), Kenes International, Geneva, Switzerland (2005), pp. 599-600.

2006 [117] I. Paolini, F. Nuti, G. Sabatino, M. Chelli, A.M. Papini. Microwave-assisted synthesis of N-glycosylated building blocks. In: Understanding Biology Using Peptides. S.E. Blondelle (Ed.), American Peptide Society, San Diego, USA (2006), pp. 190-191. [118] B. Mulinacci, C. Breithaupt, P.P. Pal, N. Budisa, M. Pazzagli, B. Mazzanti, P. Rovero, L. Moroder, A.M. Papini. Cross-reactivity studies of rMOGED with synthetic putative autoantigens CSF114(Glc) and [N31(Glc)]hMOG(30-50) in Multiple Sclerosis patients’ sera. In: Understanding Biology Using Peptides. Vol. 9, Part 11, pp. 769-770. (2006). S.E. Blondelle (Ed.), Springer New York, USA. Pubblicato Tuesday, October 23, 2007. ISBN 978-0-387-26569-8 (Print) 978-0-387-26575-9 (Online). [119] F. Nuti, I. Paolini, E. Peroni, F. Real-Fernandez, M. Pazzagli, M.C. Pozo-Carrero, F. Lolli, M. Chelli, P. Rovero, A.M. Papini. Does an Aberrant Glucosylation Trigger Autoimmunity in Multiple Sclerosis? In: Understanding Biology Using Peptides. Vol. 9, Part 11, pp. 775-776 (2006). S.E. Blondelle (Ed.), Springer New York, USA. Pubblicato October 23, 2007. ISBN 978-0-387-26569-8 (Print) 978-0-387-26575-9 (Online). [120] M.C. Alcaro, F. Barbetti, F. Nuti, F. Real-Fernandez, B. Mazzanti, M. Chelli, P. Rovero, A.M. Papini. Optimization of Multiple Sclerosis Antigenic Probes by a Combinatorial Approach. In: Understanding Biology Using Peptides Vol. 9, Part 11, pp. 779-780 (2006). S.E. Blondelle (Ed.), Springer New York, USA. Pubblicato October 23, 2007. ISBN 978-0-387-26569-8 (Print) 978-0-387-26575-9 (Online). [121] E.S. Bulukin, E. Peroni, M. Minunni, M. Pazzagli, P. Rovero, M. Mascini, A.M. Papini. Development of an Efficient Multiple Sclerosis Diagnostic Technology Based on an Optical Glycopeptide Immunosensor. In: Understanding Biology Using Peptides. Vol. 9, Part 11, pp. 785-786. (2006), S.E. Blondelle (Ed.), Springer New York, USA. Pubblicato October 23, 2007. ISBN 978-0-387-26569-8 (Print) 978-0-387-26575-9 (Online).

2007 [122] B. Kolesińska, J. Kolesińska, A. Frymarkiewicz, K.K. Wąsikowska, N. Piątkowska, K. G. Jastrząbek, G. Sabatino, F. Rizzolo, A.M. Papini, Z.J. Kamiński. Synthesis of building blocks for peptide synthesis by using 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methyl-morpholinium toluene-4-sulfonate. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 518-519. [123] D. D'Addona, F. Gori, A. Di Cianni, F. Bucelli, M. Chelli, A.M. Papini, A. Carotenuto, M. Ginanneschi. A new synthetic approach to unsaturated and saturated dicarba-analogues of octreotide. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 582-583. [124] F. Nuti, E. Peroni, E.S. Bulukin, M. Minunni, B. Mulinacci, M. Chelli, M. Mascini, P. Rovero, A.M. Papini. Improvement of autoantibody detection in autoimmune diseases by innovative solid-phase glycopeptide based technologies. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 588-589.

[125] B. Kolesińska, J. Kolesińska, A. Frymarkiewicz, K.K. Rożniakowski, G. Sabatino, F. Rizzolo, A.M. Papini, Z.J. Kamiński. Sulfonates of N-triazinylammonium salts as highly efficient, inexpensive and environmentally friendly coupling reagents for peptide synthesis in solution. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 604-605. [126] B. Kolesińska, S. Grabowski, I. Konieczna, W. Kaca, E. Peroni, A. Papini, P. Rovero Z.J. Kamiński. Immunoenzymatic assay with peptide antigens immobilized on cellulose: effect of the linker on antibody recognition. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 616-617. [127] I. Paolini, F. Nuti, E. Peroni, F. Lolli, M. Chelli, P. Rovero, A.M. Papini. An universal peptide scaffold to develop antigenic probes specific for autoimmune diseases. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 672-673. [128] A. Le Chevalier, N. Lubin-Germain, J. Uziel, M. Chelli, F. Lolli, P. Rovero, A.M. Papini. Sugar building-blocks for solid-phase glycopeptides synthesis. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 680-681 [129] M.C. Alcaro, A. Carotenuto, C. Bonaccini, B. Mulinacci, G. Bonechi, F. Lolli, M. Chelli, P. Gratteri, A. Tramontano, E. Novellino, A.M. Papini, P. Rovero. Conformationally driven rational design of glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 684-685. [130] N. Alexandris, M.C. Alcaro, R. Bianchini, A.M. Papini. Design and Synthesis of heme peptides for bioremediation. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 688-689. [131] F. Rizzolo, G. Sabatino, I. Paolini, M.C. Alcaro, M.R Moncelli, R. Guidelli, M. Chelli, A.M. Papini, P. Rovero. An efficient microwave-assisted solid phase synthesis of gramicidin a for studies in bilayer-lipid membrane. In: Peptides 2006. K. Rolka, P. Rekowski, J. Silberring (Eds.), Kenes International, Geneva, Switzerland (2007), pp 690-691.

2008 [132] F. Rizzolo, G. Sabatino, M. Fridkin, M. Chelli, P. Rovero, and A.M. Papini. Microwave-assisted solid-phase peptide synthesis: shifting off the limitations affecting conventional synthetic strategies. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 156-157. ISBN 978-952-92-5198-8. [133] M.A. Bonache, F. Nuti, A. Le Chevalier Isaad, E. Peroni, M. Chelli, P. Rovero, A.M. Papini. New Building Blocks Useful For The Synthesis Of Ribosylated Peptides. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 188-189. ISBN 978-952-92-5198-8. [134] A. Le Chevalier Isaad, M. Scrima, S. Cantel, J. Levy, P. Rovero, A.M. D'Ursi, M. Chorev, A.M. Papini. Synthesis of a Series of Cyclic i-to-i+4 Side Chain-to-Side Chain 1,4-Disubstituted [1,2,3]triazolyl-Bridged PTHrP(11-19) Derivatives. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 200-201. ISBN 978-952-92-5198-8.

[135] M. Scrima, A. Le Chevalier-Isaad, M. Grimaldi, Paolo Rovero, A.M. Papini, M. Chorev, A.M. D'Ursi. Conformational Preferences of Cyclopeptides Formed by i-to-i+4 Side Chain-to-Side Chain Cyclization via 1,4-Disubstituted [1,2,3]Triazolyl Moiety. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 266-267. ISBN 978-952-92-5198-8. [136] A. Di Cianni, D. D’Addona, F. Rizzolo, A.M. Papini, M. Ginanneschi. On-resin microwaves-assisted ring closing metathesis for rapid synthesis of octreotide dicarba-analogues. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 274-275. ISBN 978-952-92-5198-8. [137] F. Nuti, N. Qvit, F. Rizzolo, M. Hurevich, E. Peroni, M. Chelli, P. Rovero, C. Gilon, A.M. Papini. Microwave-Assisted Solid Phase Synthesis of Backbone Cyclic Glycopeptide Libraries. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 278-279. ISBN 978-952-92-5198-8. [138] A.M. Papini. Peptide-based immunoassays for biomarkers detection: a challenge for translational research. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 438-439. ISBN 978-952-92-5198-8. [139] F. Gori, B. Mulinacci, A.M. Papini, P. Rovero, and A.G. Beck-Sickinger. Semi-synthetic approaches to glycosylation of MOG as autoantigen in Multiple Sclerosis disease. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 444-445. ISBN 978-952-92-5198-8. [140] E. Innocenti, E. Peroni, F. Nuti, M. Chelli, P. Rovero, C. Selmi and A. M. Papini. Post translational modified peptide-based ELISA to detect autoantibodies in Primary Biliary Cirrhosis. In Peptides 2008 H. Lankinen, J. Vallivirta, T. Strandin, J. Hepojoki (Eds.) 2008. pp 470-471. ISBN 978-952-92-5198-8.

2009 [141] M.C. Alcaro, A. Carotenuto, F. Nuti, I. Paolini, E. Peroni, G. Sabatino, E. Novellino, F. Lolli, A.M. Papini, and P. Rovero. Modified peptides for the diagnosis of autoimmune diseases. New Perspective in Medicinal Chemistry (2009), Vol. 1: 149-158. [142] E. Peroni, M. Tontini, B. Mulinacci, M. Chelli, F. Lolli, P. Rovero, and A.M. Papini. A Glycopeptide-based Technique for Selective Antibodies Purification. In: Peptides for Youth S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 369-370. ISBN: 978-0-387-73656-3 [143] M.A. Bonache, A. Le Chevalier, F. Nuti, E. Peroni, M. Chelli, P. Rovero, and A.M. Papini. Ribose Building Block For The Synthesis Of Glycopeptides For Fishing Out Antibodies In Autoimmune Diseases. In: Peptides for Youth S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 441-442. ISBN: 978-0-387-73656-3. [144] F. Nuti, B. Mulinacci, E. Peroni, M.C. Alcaro, I. Paolini, F. Benedetti, A. Carotenuto, F. Ciolli, F. Lolli, M. Chelli, P. Rovero, and A.M. Papini. Studies for Identification of the Minimal Epitope(s) mimicked by the Synthetic Glucopeptide CSF114(Glc). In: Peptides for Youth S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 431-432. ISBN: 978-0-387-73656-3 [145] F. Gori, B. Mulinacci, E. Bonchi, M. Chelli, F. Lolli, A.M. Papini, and P. Rovero. Semi-Synthetic Strategies to Obtain Glucosylated MOG to Identify Antibodies as Biomarkers in Multiple

Sclerosis Disease. In: Peptides for Youth S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 327-328. ISBN: 978-0-387-73656-3. [146] F. Real-Fernández, A. Chamois-Colson, J. Bayardon, F. Nuti, E. Peroni, M.R. Moncelli, R. Meunier-Prest, S. Jugè, and A.M. Papini. Synthesis Of Organometallic Glycopeptides And Electrochemical Studies To Detect Autoantibodies In Multiple Sclerosis Patients´ Sera. In: Peptides for Youth. S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 435-436. ISBN: 978-0-387-73656-3. [147] S. Carganico, M.A. Bonache, M.C. Alcaro, M. Chelli, P. Rovero, M. Chorev, A. Lapolla, P. Traldi, and A.M. Papini. Synthetic strategies to Advanced Glycation End products peptides involved in diabetes. In: Peptides for Youth. S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. ISBN: 978-0-387-73656-3. [148] S. Cantel, J.A. Halperin, M. Chorev, M. Scrima, A.M. D’Ursi, J.J. Levy, R.D. Di Marchi, A. Le Chevalier, P. Rovero, and A.M. Papini. Side chain-to-Side chain Cyclization by Intramolecular Click Reaction - Building Blocks, Solid Phase Synthesis and Conformational Characterization. In: Peptides for Youth. S. Del Valle, E. Escher, W.D. Lubell (Eds.), Springer (2009), pp. 175-176. ISBN: 978-0-387-73656-3.

2010 [149] S. Pandey, E. Peroni, M.C. Alcaro, F. Rizzolo, M. Chelli, P. Rovero, F. Lolli, A.M. Papini. Mimicry Effect of the Neo-Epitope [Asn641(Glc)]FAN(635-655) with CSF114(Glc) Detecting Autoantibodies in Multiple Sclerosis. In: Peptides 2010. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 4-5. ISBN 0-9715560-5-9. [150] C. Testa, S. Carganico, F. Nuti, M. Scrima, A.M. D’Ursi, M.L. Dirain, N. Lubin Germain, C. Haskell-Luevano, M. Chorev, P. Rovero and A.M. Papini. Stabilization of β Turn Conformation in Melanocortin-Like Peptide by Click Side Chain-To-Side Chain Cyclization. In: Peptides 2010. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 14-15. ISBN 0-9715560-5-9. [151] G. Cane, A. Di Cianni, M. Lumini, AM. Papini, and M. Ginanneschi. An Efficient MW-Assisted Synthesis of Dicarba-Analogues. In: Peptides 2010. Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 184-185. ISBN 0-9715560-5-9. [152] F. Rizzolo, F. Nuti, S. Pandey, M. Chelli, P. Rovero, A.M. Papini. Microwave-Assisted Solid Phase Synthesis of [Asn641(Glc)]FAN(635-655): A New Case Study for Optimisation of Glycopeptide Synthesis. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 186-187. ISBN 0-9715560-5-9. [153] F. Rizzolo, C. Testa, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. Conventional and Microwave-Assisted SPPS Approach: A Comparative Study of PTHrP(1-34)NH2 Synthesis. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 188-189. ISBN 0-9715560-5-9. [154] M. Scrima, A.M. Papini, M. Chorev, A.M. D’Ursi. Molecular Dynamics Calculation and NMR Conformational Studies of Heterodetic Triazolyl Cyclo-Nonapeptides: A Comparative Study. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 220-221. ISBN 0-9715560-5-9. [155] S. Pandey, D. Lambardi, F. Real-Fernández, M.C. Alcaro, E. Peroni, M. Chelli, A.M. Papini, F. Lolli, P. Rovero. Recognition of Cytoskeletal Proteins Monoclonal IgGs by CSF114(Glc), the

Synthetic Probe of Multiple Sclerosis. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 290-291. ISBN 0-9715560-5-9. [156] M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, C. Tiberti, A.M. Papini. Celiac Disease: Synthesis of Overlapping Linear Peptide Epitopes of tTG[Aa(1-230)]. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 492-493. ISBN 0-9715560-5-9. [157] M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, C. Tiberti, A.M. Papini. Celiac Disease: Characterization of Amino Acids and Short Peptides Finger Print for a Fast I.V.D. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 494-495. ISBN 0-9715560-5-9. [158] F. Real-Fernández, I. Passalacqua, E. Peroni, F. Lolli, P. Rovero, A.M. Papini. Characterisation of the Minimal Epitope Detecting Autoantibodies in Multiple Sclerosis by Surface Plasmon Resonance. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 498-499. ISBN 0-9715560-5-9. [159] F. Gori, B. Mulinacci, L. Massai, F. Lolli, A.M. Papini, P. Rovero. Antigenic Probes for Autoantibody Detection in Multiple Sclerosis: Synthetic Peptides versus Recombinant Proteins. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 500-501. ISBN 0-9715560-5-9. [160] S. Pandey, E. Peroni, P. Rovero, F. Lolli, M. Chelli, A.M. D’Ursi, A.M. Papini. Rational Design and Optimization of the Newly Designed Glycopeptide Sequence to Develop the Diagnostic/Prognostic Assay for Multiple Sclerosis. In: Peptides 2010 Michal Lebl, Morten Meldal, Knud J. Jensen, Thomas Hoeg-Jensen (Editors). 2010 pp 504-505. ISBN 0-9715560-5-9.

2012 [161] F. Nuti, F. Real-Fernandez, G. Rossi, S. Pandey, G. Sabatino, C. Tiberi, M. Larregola, S. Lavielle, J. Hayek, C. De Felice, P. Rovero, A.M. Papini. Autoantibodies to N-glucosylated peptide sequons in Rett syndrome: the first insight to disclose an autoimmune mechanism. In: In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 432-433. ISBN 978-960-466-121-3. [162] C. Rentier, F. Nuti, M. Chelli, G. Pacini, P. Rovero, C. Selmi, and A. M. Papini. First synthesis of both pure diastereomeric N6-(1,2-dithiolane-(3R or S)-pentanoyl)-N2-Fmoc-L-Lys-OH for Fmoc/tBu SPPS. In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 626-627. ISBN 978-960-466-121-3. [163] C. Rentier, O. Monasson, F. Nuti, P. Traldi, A. Lapolla, M. Larregola, P. Rovero, M. Chorev, and A. M. Papini Synthesis of glycated and glycosylated peptides to detect autoantibodies in diabetic patients’ sera. In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 186-187. ISBN 978-960-466-121-3. [164] C. Tiberi, G. Sabatino, M. Di Pisa, G. Rossi, P. Rovero, A. M. Papini SPPS of N-glucosylated Multivalent Epitopes to detect autoantibodies in Multiple Sclerosis patients’ sera In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 620-621. ISBN 978-960-466-121-3.

[165] G. Sabatino,. M. Di Pisa, F. Potenza, L. Rosi, L. Dei, A.M. Papini Statistical analysis of amino acid fingerprint to characterize protein binders in works of art. In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 644-645. ISBN 978-960-466-121-3. [166] M. Di Pisa, G. Sabatino, S. M. Chelli, P. Rovero, A. M. Papini Design and synthesis of cross-linked peptide probes for the development of an in vitro diagnostics for Coeliac Disease In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 630-631. ISBN 978-960-466-121-3 [167] S. Pandey, E. Peroni, I. Dioni, P. Rovero, A. M. Papini From aberrant N-glucosylation to alpha actinin 1 as a new candidate autoantigen of an antibody mediated form of Multiple Sclerosis In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 16-17. ISBN 978-960-466-121-3. [168] F. Rizzolo, C. Testa, D. Lambardi, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. Fast and efficient microwave-assisted monitoring of difficult peptide sequences. In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 410-411. ISBN 978-960-466-121-3. [169] O. Monasson, F. Rizzolo, P. Traldi, A. Lapolla, M Chorev, P.Rovero, A.M. Papini Synthesis of the first Multivalent Epitope containing Nε-(1-deoxy-D-fructosyl)lysyl as diagnostic tool for diabetes In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 596-597. ISBN 978-960-466-121-3. [170] C. Testa, D. D’Addona, M. Scrima, A. M. D’Ursi, M. L. Dirain, M. Chorev, C. Haskell-Luevano, P. Rovero, A. M. Papini. Synthesis and in vitro activity examinations of 1,4-disubstituted-[1,2,3]triazolyl-containing cyclopeptides, analogs of MT-II, obtained via i to i+5 intramolecular side chain to side chain azide-alkyne cycloaddition. In: In: Peptides 2012. G. Kokotos, V. Constantinou-Kokotou, J. Matsoukas (Editors) European Peptide Society, 2012 pp 548-549. ISBN 978-960-466-121-3.

Patents [1] “Glycopeptides, their preparation and use in the diagnosis or therapeutic treatment of Multiple Sclerosis”. Inventors: A.M. Papini , P. Rovero, M. Chelli, F. Lolli. Applicant: University of Florence, Italy. PCT (2003) WO 03000733 A2. Italian Patent n. 0001327122 (27/04/2005). Granted USA, Australian and European Patent (02/08/2005). Licensed to IMMCO Diagnostics, Buffalo, USA. [2] “Immuno-absorption columns for the subtraction of antibodies from blood with selective plasma filtration techniques”. Inventors: F. Pinto, A.M. Papini , M. Chelli, P. Rovero, F. Lolli. Applicant: University of Florence, Italy. PCT International Application (2003) WO 2003009887 Priority Application: IT 2001-FI144. [3] “Process for the preparation of N-triazinylammonium salts”. Filing date 07/11/2005. Applicant: Italvelluti S.p.a. Inventors: Z. Kaminski, A.M. Papini , B. Kolesinska, J. Kolesinska, K. Jastrzabek, G. Sabatino, R. Bianchini. PCT/EP2005/055793 (2005).

Kaminski, Zbigniew Jerzy; Papini, Anna Maria; Jastrzabek, Konrad; Kolesinska, Beata; Kolesinska, Justyna; Sabatino, Giuseppina; Bianchini, Roberto. Process for the preparation of n-triazinylammonium salts. PCT Int. Appl. (2007), 14pp. CODEN: PIXXD2 WO 2007051496 A1 20070510 AN 2007:511982 CAPLUS. Licensed to ITALVELLUTI (Italy). [4] “Somatostatin analogues” Filing date 10.03.2005. Applicant: Giuntini Mauro. Inventors: M. Giuntini, M. Ginanneschi, M. Chelli, A.M. Papini . EPC Application (2005) 05101866.1-2401 Priority Application: IT/10.03.04/ITA FI20040057. Giuntini, Mauro; Ginanneschi, Mauro; Chelli, Mario; Papini, Anna Maria. Preparation of somatostatin analogues. Eur. Pat. Appl. (2005), 10 pp. CODEN: EPXXDW EP 1598366 A1 20051123 CAN 144:7091 AN 2005:1235907 CAPLUS [5] European patent EP2050761 B1, title “Galactosylated peptides, their preparation and use in autoimmune diseases diagnosis”. Inventors: Alcaro M.C.; Chelli M.; Lolli F.; Migliorini P.; Paolini I.; Papini A.M.; Rovero P. [6] European patent application EP 2284188 A1 - US 2011028409 A1, title “Detection of anti-ribosomal P protein antibodies by means of synthetic peptides”). Inventors: Pratesi F., Alcaro M.C., Chelli M., Fantini P., Lolli F., Paolini I., Papini A.M., Rovero P., Migliorini P. EP09167004.2 (2009). Patent application number EP10168270.6 - PCT/EP2011/061006 (2010). Non exclusive licenses to Theradiag (France), DIESSE (Italy), DIAMETRA (Italy), Amar Immunodiagnostics (India). [7] "Method for the diagnosis of rheumatoid arthritis". Inventors: Alcaro M.C.; Pratesi F.; Paolini I.; Chelli M.; Lolli F.; Papini A.M.; Rovero P.; Migliorini P. Applicant Toscana Biomarkers Srl. Patent application number EP11167420.6. (2011). Non exclusive licenses to Theradiag (France), DIESSE (Italy), DIAMETRA (Italy), Amar Immunodiagno stics (India). [8] European patent application EP2402368 A1 - WO2012001103 A1, title "Histone citrullinated peptides and uses thereof". Inventori: Pratesi F., Alcaro M.C., Chelli M., Lolli F., Paolini I., Papini A.M., Rovero P., Migliorini P. Non exclusive licenses to Theradiag (France), DIESSE (Italy), DIAMETRA (Italy), Amar Immunodiagnostics (India). [9] F. Denat, D. D’Addona, C. Bernhard, A.M. Papini-Rovero, M. Chorev “Clicked somatostatin conjugated analogs for biological applications”. EP 11193530, 14.12.2011. Déposants: Université de Cergy-Pontoise CNRS and Université de Bourgogne. [10] J. Hayek, C. De Felice, A.M. Papini, P. Rovero, F. Nuti, F. Real-Fernandez, G. Sabatino, C. Tiberi (2012). Nuovi peptidi glicosilati. Azienda Ospedaliera Universitaria Senese. Licensed to Toscana Biomarkers (Italy).

Invited lectures (Period 2004-2014)

2004

[IL11] Ciclo de Cursos del Aula “Caja de Burgos” de Estudios Científicos, Avances de la Ciencia y la Tecnología, Burgos, Spagna (Invitata dal Prof. T. Torroba) February 9-10, 2004, Salòn de Actos de la Faculdad de Ciencias. 3° Curso « The contribution of bioorganic chemitry to the study of autoimmune diseases».

February 9, 2004, h. 16:30: “Lipopeptides of myelin basic protein to study the animal model of multiple sclerosis” February 10, 2004, h. 16:30: “Glycopeptides for the development of innovative prognostic tests to follow-up multiple sclerosis”. [IL12] Simposio “Direzioni future nella sclerosi multipla”, Facoltà di Medicina e Chirurgia, Università di Firenze, Dipartimento di Scienze Neurologiche e Psichiatriche, Firenze, Italia (Invitata dal Prof. S. Sorbi) 6 Aprile 2004, h. 9:40, Aula Magna della Facoltà di Medicina. “CSF114(Glc): un glicopeptide sintetico, marker innovativo di sclerosi multipla mediata da autoanticorpi [IL13 ] 5th Conference “Medicinal Chemistry: Drug Design and Development”, Conference and Cultural Centre, University of Patras, Greece (Invitata dal Prof. J. Matsoukas) March 11-13, 2004, March 11, L14, h. 15:20. “Development of the innovative designed glycopeptide CSF114(Glc), as prognostic tool for the characterization of an antibody-mediated multiple sclerosis subgroup” [IL14] 9th Naples Workshop, Peptides as Therapeutic, Diagnostics & Vaccines, Villa Orlandi, Anacapri, Italy (Invitata dal Prof. E. Benedetti) May 8-11, 2004, May 9, h. 11:10. “Peptide-based immunoassays for the diagnosis of autoimmune diseases” [IL15] Laboratoire de Synthése et Electrosynthése et Organométalliques UMR CNRS 5188 Faculté des Sciences, Dijon, France (Invitata dal Prof. S. Jugé) June 11, 2004, h. 10 :30. “Solid-phase strategy to cyclic structures” [IL16] D.E.A. Microbiologie-Enzymologie-Nutrition (Aspects Moléculaires et Cellulaires), Magistére Microbiologie-Enzymologie (3éme année). Module Biophysique et Biologie Structurale, Université Henry Poincare, Nancy 1, Faculté des Sciences et Techniques, Nancy, France (Invitata dal Dr. A. Aubry e dal Prof. B. Vitoux) December 3, 2004, h. 14.30-16.30. “Peptides portants des modifications post-traductionnelles pour le diagnostic et la thérapie de pathologies autoimmunes”.

2005 [IL17] Weizmann Institute of Science, Rehovot, Israel (Invitata dal Prof. M. Sela) January 18, 2005. “Glycosylated synthetic probes to detect disease-specific autoantibodies, biomarkers of Multiple Sclerosis” [IL18] European-Japanese Bioorganic Meeting, Okayama, Japan (Invitata dal Prof. Tetsuo Toraya) March 15-19, 2005. “CSF114(Glc): the first synthetic glycopeptide probe to follow-up disease acrivity in Multiple Sclerosis patients”. [IL19] Seminaris del Parc Cientific de Barcelona 2005, Universitat de Barcelona, Spagna (Invitata dal Prof. Fernando Albericio), May 19, 2005. “A combinatorial approach for the rational design of innovative prognostic tools for multiple sclerosis”. [IL20] Laboratoire de Synthése et Electrosynthése et Organométalliques UMR CNRS 5188 Faculté des Sciences, Dijon, France (Invitata dal Prof. C. Moise) May 2, 2005, h. 13.00. « Les bases de la synthése peptidique » [IL21] Conférences de l’Institut de Chimie des Substances Naturelles, CNRS-UPR2301, Bâtiment 27, Gif-sur-Yvette, Francia (Invitata dal Prof. Jean-Yves Lallemand), 7 Julliet, 2005, h. 11.00. “Les glycopeptides pour le développement de tests prognostiques innovatifs pour suivre la sclérose en plaque: vers un traitement thérapeutique nouveau”.

[IL22] Laboratoire de Synthése et Electrosynthése et Organométalliques UMR CNRS 5188 et Laboratoire d’Ingénierie moléculaire pour la séparation et les applications des Gaz « LIMSAG » (UMR 5633) Université de Bourgogne, Dijon, France (Invitata dal Prof. R. Guilard) 8 Julliet, 2005, h. 10:30. « Bioorganic approach for novel prognostic tests and therapeutic treatment of Multiple Sclerosis”

2006 [IL23] Center for Synthesis and Chemical Biology. Recent Advances in Synthesis and Chemical Biology V. “An Innovative Chemical Reverse Approach to the Discovery of Specific Biomarkers of Autoimmune Diseases” O'Flanagan Theatre, Royal College of Surgeons in Ireland (RCSI) (Invitata dal Prof. Kevin B. Nolan) December 15, 2006, 3.45 p.m. Dublin, Ireland.

2007 [IL24] Israeli-Italian Bi-National Conference Brain functions: from Basic Reasearchto clinical Applications, (invited by Prof. M. Tsodyks). “A chemical reverse approach to biomarker of neurological disordes.” Weizmann Institute of Science, Rehovot, Israel, March 14, 2007, 2:00-2:45 pm. [IL25] Department of Biological Chemistry, Judea & Samaria College, (invited by Dr. Gary Gellerman). “An aberrant N-glucosylation triggering autoimmunity in Multiple Sclerosis from follow-up of disease activity to specific therapeutic treatments”. Ariel, Israel, March 15, 2007, 11:00 am. [IL26] The 6th Congress of the Israeli association for Medicinal Chemistry, Weizmann Institute of Science(invited by Prof. M. Fridkin). “A chemical Reverse Approach to detect biomarkers of autoimmune diseases.” Weizmann Institute of Science, Rehovot, Israel, March 18, 2007, 9:00-9:45 am [IL27] Department of Chemistry, Bar-Ilan University,(invited by Prof. Gerardo Byk). “Optimized synthetic strategies to glycopeptides for the development of a diagnostic/prognostic test for Multiple Sclerosis.” Ramat-Gan, Israel March 19, 2007, h. 2:00 pm [IL28] Istituto di Biofisica- Unità Operativa di Pisa. Area Ricerca Pisa- S. Cataldo (invited by Dr. Santi Chillemi). “A chemical reverse approach to decte autoantibodies as biomarkers of autoimmune diseases” May, 2, 2007, 3.00 p.m. Pisa Italy. [IL29] Modern Solid Phase Peptide Synthesis & its applications. An official satellite meeting of the 7th international australian peptide symposium (invited by Dr. J. Wade). “N-Triazinylammonium coupling reagents: from the concept of superactive esters to a versatile assistance for peptide synthesis.” Port Douglas, Australia October 18, 2007, 11:00 pm. [IL30] Howard Florey Institute, University of Melbourne (Invited by Prof. John Wade) “An aberrant N-glucosylation triggering autoimmunity in Multiple Sclerosis: from an efficient follow-up of disease activity to a guide for specific therapeutic treatments” Melbourne, Australia. October 29, 2007. [IL31] “Peptide Users Group”, Spring Symposium (Invited by Mimotopes). “Optimised synthetic strategies to develop an efficient diagnostic/prognostic test for Multiple Sclerosis” Mimotopes, Melbourne, Australia. October 30, 2007.

[IL32] Burnet Institute, Austin Campus, Heidelberg, Australia (Invited by Prof. V. Apostolopoulos) “ Strategies for characterisation of a Multiple Sclerosis pattern disease based on specific autoantibodies as biomarkers” October 31, 2007.

2008 [IL33] Third ERA Chemistry 'Flash' Conference in Killarney, Ireland,.'Carbohydrates at the interfaces of biology, medicine and materials science' ERA-Chemistry Network, the Irish Research Council for Science, Engineering and Technology (IRCSET Ireland) Killarney, Ireland, 9-13 March, 2008 (invited by Prof. S. Oscarson and Prof. P. Murphy) “Aberrant glycosylations as biomarkers of autoimmune diseases correlating with disease activity: toward the development of reliable diagnostic/prognostic tools” March 13, 2008. [IL34] 6th Hellenic Forum on Bioactive Peptides, The Conference and Cultural Centre of the University of Patras, Greece, 1st Dimitrios Theodoropoulos Memorial Lecture Award (by Hellenic Peptide Society – Chairman: Prof. P. Cordopatis - e dalla in cooperation with European Peptide Society) A “Chemical Reverse Approach” to modified peptides as synthetic antigenic probes to detect autoantibodies as biomarkers of multiple sclerosis. May 18, 2008. [IL35] 5th Bulgarian Peptide Symposium 28-30 Maggio 2008 Rila Mountain, Bulgaria (invited by Prof. L. Vezenkov) “Post-translationally modified peptides to develop reliable diagnostic/prognostic assays to follow up autoimmune diseases” May 30, 2008. [IL36] Invited Professor at Département de Chimie de l’Universitè de Cergy-Pontoise, France (invited by Prof. J. Augée and Prof. T. Brigaud) « Conformationally-driven rational design and optimisation of synthetic strategies: a chemical approach to dissect the molecular mechanisms of autoimmune diseases.” April 7, 2008. [IL37-39] Invited Professor at Institut de Chimie Moléculaire de l’Université de Bourgogne, Dijon, France, Société Française de Chimie, Section Bourgogne Franche-Comté, École doctorale Carnot. Salle B401 aile B Bâtiment « Sciences Mirande » (invited by Prof. S. Jugé). June 13, 2008: Synthesis and Conformational Analysis of a Collection of Clicked PTH Peptides via Intramolecular Side-Chain-to-Side-Chain Cu(I)-Catalyzed Huisgen Reaction June 16, 2008: N-Triazinylammonium Coupling Reagents:from the Concept of Superactive Esters to a Versatile Assistance for Peptide Synthesis June 19, 2008: Microwave-Assisted Synthesis: a Challenge for Glycosylated Tools to Dissect the Molecular Mechanisms of Autoimmunity [IL40] 30th European Peptide Symposium 31 Agosto-5 Settembre 2008, Helsinki, Finland Leonidas Zervas Memorial Lecture Award 2008 (nominated by the European Peptide Society) in commemoration of L. Zervas and the outstanding contributions he made to peptide chemistry “Peptide-based immunoassays for biomarkers detection: a challenge for translational research” 31 Agosto 2008. [IL41 ] Istituto Clinico Humanitas Centro di Ricerca e Didattica, Rozzano (Milano, Italy). December 17, 2008. Title: A “Chemical Reverse Approach” to Detect Biomarkers of Autoimmune Diseases: a Challenge for Translational Research

2009

[IL42 ] Barcelona Biomedical Research Park PRBB-CRG Seminar, Pompeu Fabra University, Barcelona (Spain). February 23, 2009. Title: Peptide-based Immunoassays for Biomarkers Detection: a Challenge for Translational Research. [IL43 ] BioInItaly, Milano (Italy). April 8, 2009. Title: The Start-up Toscana Biomarkers [IL44 ] Master di II livello in “Progettazione e Sviluppo di Farmaci” Attualità nella Ricerca Farmaceutica Farmaci peptidici e peptoidici Università degli Studi di Pavia (Italy). April 17, 2009. Title: Recenti progressi nella sintesi di peptidi d’interesse biomedico. [IL45 ] BioInItaly, Milano (Italy). May 5, 2009. Title: The Start-up Toscana Biomarkers [IL46 ] MAOPS, Microwave Assisted Organic and Peptide Synthesis 2009, La Grande Motte (France). June 4-5, 2009. Title: Optimised strategies for the synthesis of biomolecules: the microwave approach to complex peptides for diagnostics. [IL47 ] Conseil Général du Val d’Oise. July 7, 2009. Title: Molecular Detection for Life Sciences (MoDeLS). A project under the Seventh Framework Programme – Regions of Knowledge Initiative [IL48 ] 11th International Congress on Amino Acids, Peptides and Proteins, Vienna (Austria). August 3-7, 2009 (Conference August 6, 2009). Title: Glycated and glycosylated amino acids for Solid-Phase GlycoPeptide Synthesis: a challenge to microwave-assisted strategies for R&D diagnostics of autoimmune diseases. [IL49 ] Barcelona BioMed Conference – Peptide engineering: Therapeutic peptides. October 26-28, 2009. Title: Click chemistry reaction: a challenge for peptide engineering to develop efficient drugs and diagnostics. [IL50 ] Does size matter? Beyond small molecule therapeutics: challenges and success stories”, Université Libre de Bruxelles, Bruxelles (Belgium). November, 6, 2009. Title: Synthetic post-translationally modified peptides for the discovery of new biomarkers of autoimmune diseases: a “Chemical Reverse Approach”. [IL51 ] Region of Osaka (Japan) Mission Economique du Val d’Oise. November 10, 2009. Title. Molecular Detection for Life Sciences (MoDeLS): A project under the Seventh Framework Programme – Regions of Knowledge Initiative. [IL52 ] Prefectural University of Osaka (Japan). November 12, 2009. Title: Post-translationally modified peptides for detection of biomarkers of immune-mediated diseases: A “Chemical Reverse Approach”. [IL53 ] State University of Osaka (Japan). November 13, 2009. Title: Molecular Detection for Life Sciences: An European Project coordinated by the Conseil Général du Val d’Oise. [IL54 ] Ricerca Impresa, Polo Scientifico di Sesto Fiorentino, Università di Firenze (Italy). December 3, 2009. Title: Molecular Detection for Life Sciences (MoDeLS): An European Project coordinated by CGVO – Ile de France. [IL55 ] Conseil Régional de Bourgogne, Dijon (France). December 9, 2009. Title: Molecular Detection for Life Sciences (MoDeLS): An Innovative Management Model of European Projects

[IL56 ] TLS Work in Progress, Centro Ricerche Novartis, Siena (Italy). December 11, 2009. Title: Toscana Biomarkers S.r.l. R&D start-up company [IL57 ] BioInItaly, Milano (Italy). December 21, 2009. Title: The Start-up Toscana Biomarkers.

2010

[IL58 ] Presentation to Cosmetic Valley in Neuville Université. February 24, 2010. Title: European Leonardo Institute of Technology@UCP. An Infrastructure to favour Innovation in Cosmetics towards Cosmeceutics. [IL59 ] Hybrigenics, Paris (France). March 10, 2010. Title: Post-translationally modified peptides to characterise specific biomarkers of immune-mediated diseases: a challenge for "theragnostics" [IL60 ] CGVO Semaine de la Recherche et de l’Innovation Cergy-Pontoise (France). May 3, 2010. Title: Molecular Detection for Life Sciences. An Institute of Technology@UCP. An Infrastructure to favour Innovation in Diagnostics: an European Model [IL61 ] XII Convegno-Scuola sulla Chimica dei Carboidrati, Gruppo Interdivisionale Chimica dei Carboidrati della S.C.I. Pontignano (Siena). June 20-23, 2010. Title: Glycated and glycosylated amino acids for Solid-Phase GlycoPeptide Synthesis: a challenge for R&D diagnostics of immune-mediated neurodegenerative diseases. [IL62 ] Abant Izzet Baysal University, Faculty of Arts & Sciences Bolu (Turkey). September 20-23, 2010. Title: 1) Post-translationally modified peptides efficiently mimicking neo-antigens: a challenge for theragnostics of autoimmune diseases. Title : 2) Click chemistry reaction: a challenge for peptide engineering to develop efficient drugs and diagnostics [IL63 ] University of Balikesir (Turkey). September 23-25, 2010. Title: Post-translationally modified peptides for detection of biomarkers of immune-mediated diseases: A “Chemical Reverse Approach”. [IL64 ] EU Project Innovation Centre, Chengdu (Sichuan, China). 5th EU-China Business & Technology Cooperation Fair” Biopharmaceutical Forum. October 18, 2010. Title: Molecular Diagnostics for Life Sciences (MoDeLS) An European Infrastructure based on a Technology Platform Network to favour R&D in SMEs [IL65 ] Université de Versailles, Saint Quentin en Yvelines (France). November 4, 2010. Title: Chemical approaches to modulate peptide secondary structures inducing specific biological recognition. [IL66 ] China – Italy Regional Cooperation Forum on Technology and Innovation, Firenze (Italy). November 11, 2010. Title: Toscana Biomarkers Srl. The proof-of-concept of an innovative approach to molecular diagnostics. [IL67 ] Juvenil Diabetes Research Foundation Workshop “Role of Beta Cell Antigen Modifications in the Pathogenesis of T1D and their Diagnostic and Therapeutic Potential”, New York (USA).

December 13th, 2010. Title: A “Chemical Reverse Approach” to detect autoantibodies as biomarkers of autoimmune diseases: a challenge for theragnostics.

2011 [IL68 ] University of Gdansk (Poland). January 17-19, 2011. Title: 1) Peptide Diagnostics and Therapeutics for Technology Transfer Title: 2) Chemical approaches to modulate peptide secondary structures inducing specific biological recognition [IL69 ] iBiTec-S, CEA/Saclay, Gif sur Yvette (France). January 25, 2011. Title: Post-translationally modified peptides to characterise specific biomarkers of immune-mediated diseases: a challenge for "theragnostics" [IL70 ] F. Hoffman La Roche, Basel (Switzerland). February 1, 2011. Title: Toscana Biomarkers S.r.l. R&D start-up company. [IL71 ] ICOA - UMR 6005 / Université d'Orléans, Orleans (France). March 30, 2011. Title: Chemical approaches to modulate peptide secondary structures inducing specific biological recognition. [IL72 ] Cycle thématique "Dynamiques des systèmes complexes" : Modélisation de macromolécules biologiques" (Organisateur Pr. R. Livi). St Martin, Université de Cergy-Pontoise. 31 March, 2011. Title: 3D structures mimicking protein biological activity: from a rational design to peptide-based diagnostics and therapeutics.

[IL73 ] Attualità nella Ricerca Farmaceutica Farmaci peptidici e peptoidici. Università degli Studi di Pavia, Pavia (Italy). April 15, 2011. Title: “Approcci sintetici per indurre strutture secondarie e modulare l'attività biologica di peptidi. Master 2nd level “Progettazione e Sviluppo di Farmaci” [IL74 ] LA NEONATOLOGIA ED OLTRE - NEONATOLOGY AND BEYOND. Sala Universitaria - Palazzo Granafei Nervegna, Brindisi. 14 Maggio 2011. Title: Ricerca di biomarcatori nelle malattie mediate dal sistema immunitario. Corso di aggiornamento [IL75 ] Ecole Doctorale, Université de Montpellier (France). May 26, 2011. Title: The importance of a “Chemical Reverse Approach” to modulate peptide secondary structures inducing specific and high affinity biological recognition. [IL76 ] Italian-German Meeting: Green and SustainableApproach to Process Intensification, Torino (Italy). 2-3 June 2011. Title: Efficient synthetic strategies aimed to R&D of diagnostics. [IL77 ] INSERM U829, Laboratoire SABNP "Structure-Activité des Biomolécules Normales et Pathologiques" Université d'Evry-Val d'Essonne (France). June 7, 2011. Title : A « Chemical Reverse Approach » to develop efficient diagnostic/prognostic assays for immune-mediated diseases. [IL78 ] Gordon Research Conference – Carbohydrates Colby College, Waterville, ME. June 21, 2011. Title: The “Chemical Reverse Approach” to develop glycopeptides as synthetic antigens characterising autoantibodies as biomarkers of neurodegenerative diseases.

[IL79 ] Dipartimento di Scienze della Vita, Università degli Studi di Trieste, Trieste (Italy). July 25, 2011. Title : A « Chemical Reverse Approach » to develop efficient and reliable diagnostics for immune-mediated diseases. [IL80 ] Meeting UCP & 3M, Neuville Université. September 1, 2011. Title: Molecular Diagnostics for Life Sciences (MoDeLS). An European Infrastructure based on a Technology Platform Network to favour R&D in SMEs.

2012

[IL81] IPSEN INNOVATION – ZI de Courtaboeuf 5, Av. Du Canada 91940 Les Ulis (France). January 18, 2012. Title: The importance of a “Chemical Reverse Approach” to modulate peptide secondary structures inducing specific and high affinity biological recognition. [IL82] Gordon Research Conference: Peptides, Chemistry & Biology of Peptides as Signals, BioMaterials and Therapeutics. Ventura Beach Marriott, Ventura, CA (USA) February 19-24, 2012, CA. Chairs: Fred R. Naider & Maria A. Bednarek. February 21, 2012. Discussion Leader: Anna Maria Papini, Session Peptide Vaccines [IL83] 1st See-Drug Workshop From chemical to systems biology – Peptide synthesis and protein production May 9-10, 2012, Patras (Greece). May 9, 2012. Title: The importance of a “chemical reverse approach” to modulate secondary structures inducing specific and high affinity biological recognition. [IL84] Scuola di Dottorato, Aula 1, Edificio E della Presidenza della Facoltà di Scienze dell'Università di Pisa, Via Buonarroti 1, Pisa (Italy). May 28, 2012. Title: Problem solving in diagnostics of immune-mediated diseases: a Chemical Reverse Approach. [IL85] 13th Naples Workshop on Bioactive Peptides, Aula Magna Partenope, Napoli (Italy). June 7-9, 2012. Title: The mimicry pathway from glycopeptides to specific protein antigens of autoimmune neurodegenerative diseases. [IL85] Saxon Biotechnology Symposium, BIO CITY LEIPZIG, Centre for Biotechnology and Biomedicine, Deutscher Platz 5, 01403 Leipzig (Germany). June 20th, 2012. Title: Post-translational modified peptides to develop efficient IVD to follow up disease activity of autoimmune diseases: a challenge for theragnostics. [IL86] 32nd European Peptide Symposium, Athens (Greece). September 2-7 2012 (Conference September 7). Title: The mimicry pathway from anti-glycopeptide antibodies to specific protein antigens of immune-mediated neurodegenerative/neuroregressive diseases: the case study of Rett syndrome. [IL87] 2nd Austrian Peptide Symposium, Vienna (Austria). November 29 2012. Title: Post-translationally modified peptides detecting autoantibodies as biomarkers of neurodegenerative diseases: A challenge for theragnostics of immune-mediated diseases. [IL88] Département de Chimie, Faculté des arts et des sciences, Université de Montreal (Québec), Salle 1035, Pavillon J.-A. Bombardier. December 12, 2012 (11h30). Title: A “Chemical Reverse Approach” to Modulate Peptide Secondary Structures Inducing Specific and High Affinity Biological Recognition.

2013 [IL89] Karlsruhe Institute of Technology , Karlsruhe (Germany). January 21, 2013. Title: Peptide secondary structures modulating biological recognition: a “chemical reverse approach”. [IL90] 22nd Polish Peptide Symposium Kudowa Zdroj (Poland). September 1-5, 2013. Title: Autoimmunity and Neurodegeneration: the Mimicry Pathway From Aberrant N-glucosylated Peptides to Specific Protein Antigens. [IL91] 4th Annual EuroPEPTIDES 2013, Clarion Congress Hotel Prague (Czech Republic). November 13-14, 2013. Title: “Optimised Synthetic Strategies to Post-Translationally Modfied Peptides as Reliable Diagnostics of Immune-Mediated Diseases”.

2014 [IL92] 1ère Edition des rencontres interdisciplinaires «Chimie-Biologie». SATT idfinnov, Cité Internationale Universitaire – Maison de Norvège, Paris (France). March 18, 2014. Title : « Projet « PepKit » Mise en place et développement d’une approche de « chimie inverse » à l’Université de Cergy-Pontoise et création de la plateforme PeptLab@UCP ». [IL93] Hungarian Peptide Symposium, Lake Balaton (Hungary). May 28, 2014. Title: “Post-translationally modified peptides to develop efficient IVDs to follow up disease activity: a challenge for theragnostics of autoimmune diseases”. [IL94] 14th Naples Workshop on Bioactive Peptides “The Renaissance era of Peptides in Drug Discovery”, Napoli (Italy), 12-14 June 2014. June 13, 2014. Keynote Lecture Title: “From an N-glucopeptide synthetic probe to an hyper-glucosylated protein antigen: a bacterial infection triggering and antibody mediated form of multiple sclerosis?”.

Oral Communications at International Symposia

2004 [OC21] I. Paolini, F. Nuti, B. Mulinacci, E. Peroni, M.C. Alcaro, G. Sabatino, B. Mazzanti, M. Chelli, A. Brandi, F. Lolli, P. Rovero, and A.M. Papini . Glicopeptidi per la diagnosi e la terapia della sclerosi multipla. Riunione Scientifica Annuale della Società Chimica Italiana Organica, Sezione Toscana, 17 Décembre, 2004.

2005 [OC22] B. Mulinacci, C. Breithaupt, P.P. Pal, N. Budisa, M. Pazzagli, B. Mazzanti, P. Rovero, L. Moroder, and A.M. Papini . Cross-reactivity studies of rMOGED with the synthetic putative autoantigen CSF114(Glc) and [N31(Glc)]hMOG(30-50) in Multiple Sclerosis patients’ sera. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005. Bert Schram Price for Young Investigators. LY 03, Abstract p. 484 (presentato dalla Dottoranda B. Mulinacci). [OC23] A.M. Papini, M.C. Alcaro, E. Peroni, B. Mulinacci, A. Carotenuto, G. Sabatino, B. Mazzanti, M. Pazzagli, M.C. Pozo-Carrero, F. Nuti, L. Battistini, M. Chelli, F. Lolli, and P. Rovero. A combinatorial approach to optimise a prognostic test to follow-up Multiple Sclerosis disease activity. EUROCOMBI3, Winchester, U.K., 18-21 Juillet, 2005, Abstract p. 34.

[OC24] F. Lolli, M. Chelli, P. Rovero, and A.M. Papini . An aberrant N-glucosylation triggering autoimmunity in Multiple Sclerosis. XVIII International Symposium on Glycoconjugates, Glyco XVIII, 4-9 Septembre, 2005, Florence, Italie. L160, Glycoconjugate J., 2005, 22(4–6), 220. [OC25] B. Kolesinska, Z. Kaminski, and A.M. Papini . New generation of Triazine-based Coupling Reagents. 18th Polish Peptide Symposium, Wroclaw, Pologne, 4-8 Septembre, 2005, Abstract L-18. [OC26] F. Lolli, M. Chelli, P. Rovero, and A.M. Papini. Role of glycosylation in autoimmune diseases. Mini-Symposium “Multidisciplinary approaches to dissect the molecular mechanisms of diseases”, First European Conference on Chemistry for Life Sciences, Rimini, Italie, 4-8 Octobre, 2005, Lecture, Abstract p. 73.

2006 [OC27] A.M. Papini . An aberrant glucosylation of myelin proteins triggering autoimmunity in Multiple Scleorsis. Chemistry & Biology of Peptides, Gordon Research Conference, February 19-24, 2006 Ventura Beach Marriott, CA, USA. [OC28] A.M. Papini, A. Carotenuto, M.C. Alcaro, B. Mulinacci, E. Peroni, G. Sabatino, F. Nuti, I. Paolini, M. Chelli, F. Lolli, and P. Rovero. From aberrant post translational modifications of myelin proteins to synthetic antigen probes detecting biomarkers of autoimmune diseases. Promelab, 1st International Workshop on Expression, Function & Structure of Membrane Proteins. 18-22 June 2006, Firenze, Italy. [OC29] A.M. Papini , M. C. Alcaro, B. Mulinacci, E. Peroni, G. Sabatino, F. Nuti, I. Paolini, M. Chelli, F. Lolli and P. Rovero. From aberrant post translational modifications of proteins to synthetic antigenic probes detecting biomarkers of autoimmune diseases. 1st European Chemistry Congress, 27-31 August 2006, Budapest, Hungary (Comunicazione orale presentatata dall’assegnista di ricerca B. Mulinacci). [OC30] B. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, J. Kolesinska, K.G. Jastrzabek, Z.J. Kaminski, and A.M. Papini . A new generation of N-triazinylammonium coupling reagents versatile for peptide synthesis by different strategies. 29th European peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract L009. [OC31] G. Sabatino, B. Kolesinska, M. Chelli, J. Kolesinska, P. Rovero, Z. Kaminski, and A.M. Papini. A new generation of N-triazinylammonium coupling reagents versatile for peptide synthesis by different strategies. XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006. Abstract ORG-F-17 (Flash Communication presentata dall’assegnista di ricerca G. Sabatino). [OC32] M.C. Alcaro, A. Carotenuto, A.M. D’Usi, C. Bonaccini, F. Barbetti, F. Lolli, M.Chelli, A. Tramontano, E. Novellino, A.M. Papini , and P. Rovero. Conformationally Driver Rational Design of Glycopeptides as Synthetic Probes for the Detection of Autoantibodies, Biomarkers of Multiple Sclerosis. XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006. Abstract GCP-O-06 (Comunicazione orale presentata dall’assegnista di ricerca M.C. Alcaro).

2007

[OC33] A.M. Papini An innovative “chemical reverse approach” for autoimmune diseases diagnosis: a consistent strategy to include aberrant post-translational modifications. 4th International Peptide Symposium, 7° Australian Peptide Symposium & 2nd Asian Pacific International Peptide Symposium, Cairns, QLA, Australia, October 21-25, 2007. Abstract 26.

2010 [OC34] C. Testa, S. Carganico, F. Nuti, M. Scrima, A. M. D’Ursi, M. L. Dirain, N. Lubin Germain, C. H. Luevano, M. Chorev, P. Rovero, A. M. Papini. Stabilization of β�-turn conformation in melanocortin like peptide by click side chain-to-side chain cyclization. 31st European Peptide Symposium, 31st EPS, Copenhagen (Denmark), 5-9 September 2010. Oral O8 [OC35] S. Pandey, E. Peroni, MC Alcaro, F. Rizzolo, F. Nuti, M. Chelli, S Matà, P. Rovero, F. Lolli, AM. Papini. Mimicry effect of the neo-epitope [Asn641(Glc)]FAN(635-655) with CSF114(Glc) detecting autoantibodies in Multiple Sclerosis, 31th European Peptide Symposium, Copenhagen (Denmark), 5-9 September 2010. Abstract O1

2012 [OC36] Rentier, C. and Papini, A.M. Aberrant post-translationally modified peptides for diagnostics and monitoring of autoimmune diseases 3rd Ph.D. Day, Florence (Italy), May 16, 2012. [OC37] C. Rentier, O. Monasson, F. Nuti, E. Peroni, G. Pacini, G. Rossi, M. Larregola, P. Rovero and A.M. Papini. Synthesis of post-translationnally modified peptides as molecular probes for immune-mediated diseases: the case of Primary Biliary Cirrhosis. 18th Congress of GFPP, May 28th, Le Lazaret, Sète (France). Abstract O11, pag. 43.

2014 [OC38] C. Rentier, G. Pacini, F. Nuti, C. Selmi, P.M. Battezzati, P. Rovero and A.M. Papini Peptides of the dihydrolipoyl acetyltransferase for the detection of autoantibodies in autoimmune diseases. 14th Naples Workshop on Bioactive Peptides “The Renaissance Era of Peptides in Drug Discovery”, Naples (Italy), June 12-14 2014.

Poster presentations to International Symposia

2004 [P74] M. C. Alcaro, E. Naldini, B. Mulinacci, B. Mazzanti, M. Pazzagli, F. Lolli, M. Chelli, P. Rovero, and A.M. Papini . Identification of new autoantigens in Multiple Sclerosis by glycopeptide libraries. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P125, Abstract p. 153. [P75] B. Mulinacci, I. Paolini, A. Carotenuto, B. Mazzanti, M. Pazzagli, M. Chelli, F. Lolli, P. Rovero, and A.M. Papini . β-hairpin glycopeptides as mimetic autoantigens in Multiple Sclerosis. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P303, Abstract p. 199.

[P76] I. Paolini, F. Nuti, B. Kolesinska, F. Cardona, M. Chelli, B.Mazzanti, F. Lolli, A. Brandi, and A.M. Papini . Optimisation of synthetic strategies to glycosylated amino acids. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P306, Abstract p. 200. [P77] E. Peroni, F. Peri, F. Nuti, B. Mazzanti, M. Chelli, and A.M. Papini . An innovative approach to the synthesis of N-glycopeptides. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P307, Abstract p. 200. [P78] G. Sabatino, B. Kolesinska, M. Chelli, P. Rovero, Z. J. Kaminski, and A.M. Papini . A comparative study on new not azabenzotriazole-based coupling reagents for SPPS. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P56, Abstract p. 134. [P79] M.C. Pozo Carrero, B. Kolesinska, G. Sabatino, M. Chelli, P. Rovero, Z.J. Kaminski, and A.M. Papini . Synthesis of useful building blocks for peptide synthesis: a comparative study of different coupling reagents for ester and amide bonds. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P51, Abstract p. 133. [P80] J. Kolesinska, B. Kolesinska, A.M. Papini , and Z.J. Kaminski. N-Triazinylammonnium tetrafluoroborates as new, highly efficient coupling reagents for peptide synthesis in solution. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P106, Abstract p. 147. [P81] K. Jastrząbek, M. Błaszczyk, M.L. Główka, B. Kolesinska, A.M. Papini , and Z.J. Kaminski. 2-Chloro-4,6-dibenzyloksy-1,3,5-triazine and N-(3,5-dibenzyloxy-1,3,5-triazinyl-1)ammonium tetrafluoroborates as highly efficient coupling reagents for peptide synthesis in solution. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P105, Abstract p. 147. [P82] B. Kolesinska, G. Sabatino, J. Kolesinska, M. Chelli, P. Rovero, Z.J. Kaminskiand, A.M. Papini. New generation of triazine-based coupling reagents useful for SPPS. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P33, Abstract p. 129. [P83] A.M. Papini , B. Kolesinska, G. Sabatino, J. Kolesinska, Z.J. Kaminski. Selection of the best triazine-based condensing reagent for SPPS. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 Septembre, 2004, P49, Abstract p. 133. [P84] B. Mazzanti, M. Pazzagli, M.C. Alcaro, B. Mulinacci, E. Peroni, F. Nuti, G. Sabatino, M.C. Pozo-Carrero, A. Carotenuto, B. Bonetti, L. Battistini, D. Franciotta, S. Sotgiu, R. Lanzillo, M. Chelli, P. Rovero, F. Lolli, and A.M. Papini . A proteomic approach to characterize a native antigen involved in autoantibody response in Multiple Sclerosis by a structure-based designed glycopeptide. Seventh International Congress of the International Society of Neuroimmunology, Venise (Italie) 28 Septembre-2 Octobre, 2004, Abstract 313 in: J. Neuroimmunol. (2004) 154, 95.

2005 [P85] M.C. Alcaro, P. Rovero, and A.M. Papini . Fishing for antigens recognizing autoantibodies in Multiple Sclerosis. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005, PY 20, Abstracts p. 507.

[P86] E. Bulukin, E. Peroni, M. Minunni, M. Pazzagli, P. Rovero, M. Mascini, and A.M. Papini. Development of an efficient Multiple Sclerosis diagnostic technique based on an optical glycopeptide immunosensor. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005. [P87] E. Peroni, M.C. Alcaro, F Barbetti, F. Nuti, F. Real-Fernàndez, B. Mazzanti, M.Chelli, P. Rovero, and A.M. Papini. Combinatorial approach to develop the optimal glycopeptide as molecular probe to characterize autoantibodies in Multiple Sclerosis. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005, PY 46, Abstracts p. 512. [P88] F.Nuti, I. Paolini, B.Mazzanti, F. Real-Fernàndez, M.C. Pozo-Carrero, M. Chelli, P.Rovero, and A.M. Papini . Asparaginyl glucose is fundamental for autoantibody recognition in Multiple Sclerosis. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005, PY 17, Abstracts p. 507. [P89] G. Sabatino, I. Paolini, M.C. Pozo-Carrero, M. Chelli, P. Rovero, and A.M. Papini . Optimized conditions for glycopeptide synthesis by a microwave peptide synthesizer. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005, PY 16, Abstracts p. 507. [P90] I. Paolini, F. Nuti, I. Matteini, G. Sabatino, M. Chelli, and A.M. Papini . Microwave-assisted synthesis of glycosylated building blocks. 19th American Peptide Symposium, San Diego, CA, USA, 18-24 Juin, 2005, PY 15, Abstracts p. 507. [P91] E. Peroni, E. Bulukin, M. Minunni, M. Pazzagli, P. Rovero, M. Mascini, and A.M. Papini . Development of a high-throughput screening for Multiple Sclerosis patients’ sera based on an optical glycopeptide immunosensor. EUROCOMBI-3 conference, Winchester, U.K. 18-21 Juin, 2005. Abstract p. 98 [P92] K. Jastrzabek, B. Kolesinska, A.M. Papini , G. Sabatino, and Z. Kaminski. 2-Chloro-4,6-dibenzyloxy-1,3,5-triazine and its quaternary N-1,3,5-triazinylammonium salts. Highly efficient coupling reagents of new generation with modified substituents in triazine ring. 18th Polish Peptide Symposium, Wroclaw, Pologne, 4-8 Septembre, 2005, Abstract P-33W. [P93] F. Nuti, I. Paolini, B.Mulinacci, M. Pazzagli, F. Lolli, M. Chelli, P. Rovero, and A.M. Papini. Sugar-scan of CSF114(Glc) for autoantibody recognition in Multiple Sclerosis. XVIII International Symposium on Glycoconjugates. Glyco XVIII”, Florence (Italie), 4-9 Septembre, 2005, Abstract P057, Glycoconjugate J., 2005, 22(4–6), 254. Best Poster Award. [P94] F. Rizzolo, B. Mulinacci, F. Nuti, M. Pazzagli, M. Chelli, F. Lolli, P. Rovero, and A.M. Papini. Synthesis of glucosylated peptides: role of the amino acid sequence in autoantibody recognition in Multiple Sclerosis patients’ sera. XVIII International Symposium on Glycoconjugates. Glyco XVIII”, Florence (Italie), 4-9 Septembre, 2005, Abstract P063, Glycoconjugate J., 2005, 22(4–6), 257. [P95] B. Mulinacci, C. Breithaupt, N. Budisa, P. Rovero, L. Moroder, and A.M. Papini . Cross-reactivity studies of rMOGED with the synthetic putative autoantigen CSF114(Glc) in Multiple Sclerosis patients’ sera. XVIII International Symposium on Glycoconjugates. Glyco XVIII”, Florence (Italie), 4-9 Septembre, 2005, Abstract P262, Glycoconjugate J., 2005, 22(4–6), 337.

[P96] A. Le Chevalier, M. Ousmer, N. Lubin-Germain, J. Uziel, E. Peroni, M. Chelli, F. Lolli, P. Rovero, and A.M. Papini . Role of glucose bonding to amino acids in myelin proteins for autoantibody recognition in Multiple Sclerosis. XVIII International Symposium on Glycoconjugates. Glyco XVIII”, Florence (Italie), 4-9 Septembre, 2005, Abstract P051, Glycoconjugate J., 2005, 22(4–6), 252. [P97] G. Fontanive, I. Adamo, F. Berti, F. Benedetti, I. Paolini, and A.M. Papini . Stereoselective synthesis of pseudopeptides containing the minimal epitope fundamental for antibody recognition in Multiple Sclerosis. 1st European Conference on Chemistry for Life Sciences, Rimini (Italie), 4-8 Octobre, 2005, Poster, Abstract p. 97. [P98] M. Ginanneschi, D. D’Addona, F. Gori, M. Chelli, A.M. Papini , and F. Bucelli. Synthesis of new octreotide dicarba-analogues. 1st European Conference on Chemistry for Life Sciences, Rimini (Italie), 4-8 Octobre, 2005, Poster, Abstract p. 115. [P99] M. de la Cruz Pozo-Carrero, F. Nuti, I. Paolini, G. Sabatino, M. Pazzagli, M. Chelli, F. Lolli, P. Rovero, and A.M. Papini . An aberrant N-glucosylation triggering autoimmunity in Multiple Sclerosis. 1st European Conference on Chemistry for Life Sciences, Rimini (Italie), 4-8 Octobre, 2005, Poster, Abstract p. 157. [P100] G. Sabatino, Z.J. Kamiński, B. Kolesińska, J. Kolesińska, M. Pozo-Carrero, M. Chelli, P. Rovero, and A.M. Papini . New generation of a Triazine-Based coupling reagent useful for a large scale solid-phase synthesis of a specific Multiple Sclerosis antigenic probe. 1st European Conference on Chemistry for Life Sciences, Rimini (Italie), 4-8 Octobre, 2005, Poster, Abstract p. 161.

2006 [P101] M.C. Alcaro, B. Mulinacci, G. Bonechi, F. Barbetti, I. Paolini, E. Peroni, F. Nuti, G. Sabatino, M. Chelli, C. Bonaccini, A. Tramontano, F. Lolli, A. Carotenuto, P. Rovero, and A. M. Papini. Looking for native antigens triggering an autoantibody response in Multiple Sclerosis. Chemistry & Biology of Peptides, Gordon Research Conference, February 19-24, 2006 Ventura Beach Marriott, CA, USA. [P102] E. Peroni, I. Paolini, F. Nuti, B. Mulinacci, G. Sabatino, M. C. Alcaro, E. S. Bulukin, F. Lolli, M. Chelli, P. Rovero, and A. M. Papini. A universal peptide scaffold to develop antigenic probes specific for autoimmune diseases. Chemistry & Biology of Peptides, Gordon Research Conference, February 19-24, 2006 Ventura Beach Marriott, CA, USA. [P103] B. Mulinacci, C. Breithaupt, P.P. Pal, N. Budisa, M. Pazzagli, B. Mazzanti, P. Rovero, L. Moroder, and A.M. Papini . Cross-reactivity studies of rMOGED with the synthetic putative autoantigen CSF114(Glc) and [N31(Glc)]hMOG(30-50) in Multiple Sclerosis patients’ sera. Promelab, 1st International Workshop on Expression, Function & Structure of Membrane Proteins. June 18-22, 2006, Firenze, Italy. [P104] C. Tommasi, M.C. Alcaro, C. Anzilotti, D. Chimenti, F. Pratesi, M. Rosati, A.M. Papini, P. Rovero, P. Migliorini. Synovial Antigens Target of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis. 1st Congress of the Italian Proteomic Association (ItPA), Pisa (Italy), July 2-4, 2006, Abstract H47.

[P105] B. Kolesinska, S. Grabowski, W. Kaca, E.Peroni, A.M. Papini, P. Rovero, and Z.J. Kaminski. Immunoenzymatic assay with peptide antigens immobilised on cellulose: effect of the linker on antibody recognition. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract Th480. [P106] A. Carotenuto, M.C. Alcaro, C. Bonaccini, F. Barbetti, F. Lolli, M. Chelli, A. Tramontano, E. Novellino, A.M. Papini, and P. Rovero. Conformationally driven rational design of glycopeptides as synthetic probes for the detection of autoantibodies, biomarkers of multiple sclerosis. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract Tu494. [P107] F. Nuti, E. Peroni, E.S. Bulukin, B. Mulinacci, M. Chelli, P. Rovero, and A.M. Papini. Improvement of autoantibody detection in autoimmune diseases by innovative solid-phase glycopeptide based technologies. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract M541. [P108] A. Le Chevalier, N. Lubin-Germain, J. Uziel, M. Chelli, F. Lolli, P. Rovero, and A. M. Papini. Sugar building blocks for solid-phase glycopeptides synthesis. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract M028. [P109] I. Paolini, F. Nuti, E. Peroni, F. Lolli, M. Chelli, P. Rovero, and A. M. Papini. An universal peptide scaffold to develop antigenic probes specific for autoimmune diseases. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract Th504. [P110] M.C. Alcaro, B. Mulinacci, G. Bonechi, F. Barbetti, I. Paolini, E. Peroni, F. Nuti, G. Sabatino, M. Chelli, C. Bonaccini, A. Tramontano, F. Lolli, A. Carotenuto, P. Rovero, and A. M. Papini. Looking for native antigens triggering an autoantibody response in Multiple Sclerosis. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract . [P111] D. D’Addona, F. Gori, A. Di Cianni, F. Bucelli, A. Carotenuto, M. Chelli, A. M. Papini, and M. Ginanneschi. A new synthetic approach to saturated and unsaturated dicarba-analogues of octeotride. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract Th081. [P112] F. Rizzolo, G. Sabatino, I. Paolini, M.C. Alcaro, M.R. Moncelli, R. Guidelli, M. Chelli, and A.M. Papini , P.Rovero. An efficient microwave-assisted soli-phase synthesis of Gramicidin A for studies in bilayer lipid membrane. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract Th107. [P113] Nikos Alexandris, Maria Claudia Alcaro, Roberto Bianchini, and Anna Maria Papini. Design and Synthesis of heme peptides for bioremediation. 29th European Peptide Symposium, Gdansk, Poland, September 3-8, 2006, Abstract Th321. [P114] V. Volkov, R. Chelli, R. Righini, F. Nuti, and A.M. Papini . Local structure and dynamics of phospholipid membranes investigated by two-dimensional IR spectroscopy and MD simulation. XXII Congresso Nazionale della Società Chimica Italiana, Firenze, September 10-15, 2006. Abstract FIS-P-134.

[P115] V. Volkov, F. Nuti, Y.Takaoka, R. Chelli, A.M. Papini , and R. Righini. Structure and bonding of water molecules in the polar region of phospholipid membrane investigated by two-dimensional IR spectroscopy and MD computer simulation. XXII Congresso Nazionale della Società Chimica Italiana, Firenze, September 10-15, 2006. Abstract FIS-P-135. Premio per il miglior poster della Divisione di Chimica Fisica. [P116] F. Rizzolo, G. Sabatino, M.R. Moncelli, R. Guidelli, M. Chelli, and A.M. Papini , P.Rovero. A microwave-assisted synthesis of Gramicidin A for interaction studies in biomimetic membranes. XXII Congresso Nazionale della Società Chimica Italiana, Firenze, September 10-15, 2006. Abstract SBI-P-24.

2007 [P117] F. Real-Fernández, M. R. Moncelli, P. Rovero, A. M. Papini, Electrochemical studies of antigenic glycopeptides in biomimetic membranes, XIX International symposium on Bioelectrochemistry and Bioenergetics, BES 2007, Toulouse, France, 1-4 April 2007. B1-P10, Abstract p. 138. [P118] F. Gori, B. Mulinacci, E. Bonchi, M. Chelli, F. Lolli, A.M. Papini and P. Rovero. Semi-synthesis of glucosylated recombinant MOG as auto-antigen in Multiple Sclerosis. VII European Symposium of The Protein Society, Stockholm, Sweden, May 12-16, 2007 .Abstract III-87. [P119] A. Colson, J. Bayardon, E. Rémond, H. Lauréano, F. Nuti, R. Meunier-Prest, M. Kubicky, C. Darcel, A.M. Papini and S. Jugé. New β-Ferrocenyl Phosphino α-Aminoacids as Modular Electrochemical Biomarkers for CSF114(Glyco)peptides. 17th international Conference on Phosphorus Chemistry, ICPC-17 sponsored by IUPAC, Xiamen (China), April 15-19, 2007. Poster P-176. Abstract Book p 228 [P120] F Nuti, E Peroni, B Mulinacci, I Paolini, MC Alcaro, F Benedetti, F Ciolli, F. Lolli, M Chelli, P. Rovero, AM Papini . An N-glucosylated peptide as multiple sclerosis antigenic probe to fishing out autoantibodies in serum and monitoring disease activity. Benzon Symposium no. 54, Glycosylation opportunities in drug development, Copenhagen, Denmark, June 11-14, 2007. Abstract III-14 [P121] I. Paolini, M.C. Alcaro, F Nuti, P. Migliorini, F. Lolli, M. Chelli, P. Rovero, A.M. Papini. Glycosylated Peptides as Diagnostic Tools for Autoimmune Diseases: a Chemical Reverse Approach. Benzon Symposium no. 54, Glycosylation opportunities in drug development, Copenhagen, Denmark, June 11-14, 2007. Abstract III-13 [P122] M.C. Alcaro, F. Nuti, G. Bonechi, F. Benedetti, A. Carotenuto, C. Bonaccini, P. Gratteri, A. Tramontano, F. Lolli, M. Chelli, E. Novellino, P. Rovero, A.M. Papini New Generation of Families of Antigenic Probes for Detection of Multiple Sclerosis Biomarkers. 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2-381 [P123] F Nuti, E Peroni, B Mulinacci, I Paolini, MC Alcaro, F Benedetti, F Ciolli, F Lolli, M Chelli, P Rovero, A.M. Papini . Studies for identification of the minimal epitope(s) mimicked by the synthetic glucopeptide CSF114(Glc). 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2-423

[P124] F. Real Fernández, A. Chamois-Colson, G. Bayardon, F.Nuti, E.Peroni, M.R. Moncelli, R. Meunier-Prest, S. Jugè, A.M.Papini . Synthesis of organometallic glycopeptides and electrochemical studies to detect autoantibodies in multiple sclerosis patients´ sera. 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2 429. (semi-finalist participant in the Young Investigator Poster Competition-Peptide Idol). [P125] M.A. Bonache, A. Le Chevalier, F. Nuti, E. Peroni, M. Chelli, P. Rovero, A.M. Papini. Ribose building block for the synthesis of glycopeptides to fishing out antibodies in autoimmune diseases. 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2 463 [P126] F. Rizzolo, G. Sabatino, B. Kolesińska, Z.J. Kamiński, M.R. Moncelli, M. Chelli, P. Rovero and A.M. Papini . Optimized solid-phase synthesis of difficult peptide sequences: case study of Gramicidin A. 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2-426. [P127] S. Cantel, J.A. Halperin, M. Chorev, M. Scrima, A.M. D'Ursi, J. J. Levy, R.D. DiMarchi, A. Le Chevalier, P. Rovero, and A.M. Papini . Side chain-to-Side chain Cyclization by Intramolecular Click Reaction - Building Blocks, Solid Phase Synthesis and Conformational Characterization. 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2-412. [P128] S. Carganico, M.A. Bonache, M.C. Alcaro, M. Chelli, P. Rovero, A.M. Papini , M. Chorev, A. Lapolla, P. Traldi, Synthetic strategies to Advanced Glycation End products peptides involved in diabetes. 20th American Peptide Symposium, Montreal, Québec, June 26-30, 2007, Abstract PS2-425. [P129] E. Peroni, M. Tontini, B. Mulinacci, M. Chelli, P. Rovero and A.M. Papini A Glycopeptide-based Technique for Selective Antibodies Purification. 20th American Peptide Symposium Montreal, Québec, June 26-30, 2007, Abstract PS2-509. [P130] M.C. Alcaro, F. Barbetti, F. Nuti, I. Paolini, F. Real-Fernandez, A.M. Papini , and P. Rovero Evaluation of the Efficiency of Post-Translational Modified Peptide Libraries for Biomarkers Discovery. First International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials, Firenze, Italy, July 15-18, 2007, Abstract PP21. [P131] A. Le Chevalier, P. Rovero, M. Chorev, and A.M. Papini . Synthesis of N a-Protected ω-Ynoic and ω-Azido α-Amino Acids as Building Blocks for the Development of [1,2,3]Triazole Containing Peptide Libraries. Eurocombi4, Firenze, Italy, July 15-18, 2007, Abstract PP14. [P132] S. Centi, E. Bulukin, M. Minunni, E. Peroni, A.M. Papini, P. Rovero, M. Mascini. “Glycopeptide-based electrochemical immunomagnetic sensors for antibody detection in sera from autoimmuno disease patients”. EUROanalysis XIV Conference, Antwerpen Belgium, September 9-14 2007. Abstract P123.

2008

[P133] A.M. Papini. Ferrocenyl glycopeptides as electrochemical probes to detect autoantibodies in multiple sclerosis patients’ sera. Third ERA Chemistry “Flash” Conference in Killarney, Ireland,.’Carbohydrates at the interfaces of biology, medicine and materials science' Killarney, Ireland, 9-13 March, 2008.

[P134] A.M. Papini (2008). Zervas Award Memorial Lecture. Peptide-based immunoassays for biomarkers detection: A challenge for translational research. 30th European Peptide Symposium, 31 August-5 September 2008, Helsinki, Finland. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 8, ISSN: 1075-2617, doi: 10.1002/psc.1088.

[P135] Le Chevalier Isaad, M. Scrima, S. Cantel, J. Levy, P. Rovero, A.M. D'Ursi, M. Chorev, A.M. Papini (2008). Synthesis and conformational analysis of a series of cyclic i-to-i+4 side chain-to-side chain 1,4-disubstituted [1,2,3]triazolyl-bridged PTHrP(11-19) derivatives. 30th European Peptide Symposium, 31 August-5 September 2008, Helsinki, Finland. Abstract Y04. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 3, ISSN: 1075-2617, doi: 10.1002/psc.1073.

[P136] F. Real-Fernández , A. Colson, J. Bayardon, F. Nuti, E. Peroni, R. Meunier-Prest, F. Lolli, M. Chelli, C. Darcel, S. Jugé, and A.M. Papini. Electrochemical Glycopeptide Probes to Detect Autoantibodies in Multiple Sclerosis Patients’ Sera. 30th European Peptide Symposium, Helsinki, Finland, August 31-September 6, 2008, Abstract P31501-022. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 136, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P137] E. Innocenti, E. Peroni, F. Nuti, M. Chelli, P. Rovero, C. Selmi, A.M.Papini. Post translational modified peptide-based ELISA to detect autoantibodies in Primary Biliary Cirrhosis. 30th European Peptide Symposium, Helsinki, Finland, August 30-September 6, 2008, Abstract

[P138] F. Nuti, N. Qvit, F. Rizzolo, M. Hurevich, A. Carotenuto, E. Peroni,M. Chelli, P. Rovero, C. Gilon and A.M. Papini. Microwave-assisted solid phase synthesis of backbone cyclic glycopeptide libraries. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki,Finland. Abstract 30102-001. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(S), p. 131, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P139] G. Sabatino, F. Rizzolo, B. Kolesinska, M. Chelli, P. Rovero, Z.J. Kaminski, A.M. Papini (2008). Microwave-assisted attachment of Fmoc-amino acids to resins via triazine superactive esters. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki, Finland. Abstract P10104-046. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(S), p. 58-59, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P140] F. Rizzolo, G. Sabatino, E. Perugia, M. Fridkin, M. Chelli, P. Rovero, A. M. Papini (2008). Microwave-assisted solid-phase synthesis of peptide probes to detect specific biomarkers: shifting off limitations affecting conventional synthetic strategies. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki, Finland. Abstract 10417-110. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(S), p. 74-75, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P141] Di Cianni, D. D'Addona, F. Rizzolo, A.M. Papini, M. Ginanneschi (2008). On-resin microwaves-assisted Ring Closing Metathesis for the synthesis of Octreotide dicarba-analogues. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki, Finland. Abstract P20104-012. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(S), p. 83, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P142] M. Scrima, A. Le Chevalier-Isaad, S. Chantel, J.J. Levy, P. Rovero, A.M. Papini, M. Chorev, A.M. D'Ursi (2008). A new library of cyclic peptides obtained via i-to-i+4 intramolecular side chain-to-side chain azide-alkyne 1,3-dipolar cycloaddition: CD and NMR conformational analysis. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki,Finland. Abstract P22829-185. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 129, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P143] M.A. Bonache, F. Nuti, A. Le Chevalier-Isaad, E. Peroni, M. Chelli, P. Rovero, A.M. Papini (2008). New ribosylated building blocks useful for glycopeptide synthesis. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki, Finland. Abstract 30208-003. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 131, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P144] M.C. Alcaro, I. Paolini, P. Fantini, F. Barbetti, M. Chelli, P. Migliorini, F. Lolli, P. Rovero, A.M. Papini (2008). A chemical reverse approach for autoimmune diseases diagnosis. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki, Finland. Abstract P31509-024. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 137, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P145] A.M. Papini, P. Rovero, F. Lolli, M. Chelli, P. Migliorini (2008). Peptide-based a challenge for high performance diagnostics & prognostics of autoimmune diseases. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki,Finland. Abstract P31509-025. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 137, ISSN: 1075-2617, doi: 10.1002/psc.1090.

[P146] A Le Chevalier-Isaad, M. Scrima, S. Cantel, P. Rovero, A.M. D'Ursi, M. Chorev, A.M. Papini. (2008). Synthesis of a series of cyclic i-to-i+4 side chain-to-side chain 1,4-disubstituted[1,2,3]triazolyl-bridged PTHrP(11-19) derivatives. 30th European Peptide Symposium, 31 August -5 September 2008, Helsinki, Finland. Abstract P10100-020. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 52, ISSN: 1075-2617, doi: 10.1002/psc.1090.

2009 [P147] M. Frediani, D. Sémeril, F. Rizzolo, A.M. Papini, L. Rosi, M.Santella, P. Frediani, D. Matt “Lactide polymerization by acalix[4]arene titanium complex using conventional heating andmicrowave irradiation” XXVIII CONGRESSO INTERREGIONALE TUMA 2009, 20-22 September 2009, Pisa, Italy. [P148] F. Nuti, Peroni E, Carganico S, Alcaro MC, Chelli M, Migliorini P, Selmi C, Lolli F, Chorev M, Rovero P, Papini AM Post translationally modified peptides for an efficient detection of autoantibody biomarkers of autoimmune diseases. 11th International Congress on Amino Acids, Peptides and Proteins, Vienna (Austria) 3-7 Agosto 2009

[P149] I. Friligou, F. Rizzolo, J. Matsoukas, T. Tselios, P. Rovero and A. M. Papini. Microwave assisted solid phase peptidesynthesis of a multiple antigen peptide (MAP) with two branches,containing the immunodominant epitope of rat myelin, MOG35-55. 10thInternational Conference in Medicinal Chemistry: Drug Design andDevelopment, 18-20 March 2009, Patras, Greece

[P150] Peroni E, F. Nuti, F. Real-Fernández, F. Lolli, Chelli M, Rovero P, Papini AM Improvement of autoantibody detection in multiple sclerosis by solid-phase glycopeptide based technologies. France-German meeting on multiple sclerosis “18th Francois Lhermitte’s Conferences “, Paris (France) March 6, 2009 Abstract IMM-20.

2010 [P151] I. S. Rice, P. M. Thompson, F. Nuti, A. M. Papini, A. D. Wallace Impact of DEHP Metabolites on Human Androgen Receptor Activity, 49th Annual Meeting of the Society of Toxicology, Salt Lake City (USA), March 7–11, 2010

[P152] C Testa, F Nuti, M Scrima, AM D’Ursi, N Lubin Germain, M Chorev, P Rovero, AM Papini. Probing the Bioactive Conformation of melanocortin like peptide by Click Reaction. Probes for peptide science: design and methodological development, April 8-9, 2010, Abstract P28 [P153] F Nuti, F. Real-Fernández, M. A Bonache, M Boccalini, S Chimichi, M Chelli, AM. Papini Glycopeptide probes for characterising immune response in neurological diseases: design and synthetic strategies, Probes for peptide science: design and methodological development, April 8-9, 2010, Abstract P19 [P154] E Peroni, F. Nuti, F. Real Fernández, F. Lolli, M. Chelli, P. Rovero, AM Papini Improvement Of Autoantibody Detection in Multiple Sclerosis by Solid-Phase Glycopeptide Based Technologies. Probes for peptide science: design and methodological development, April 8-9, 2010, Abstract P22 [P155] J.B. Chanson, I. Paolini, N. Collongues, M.C. Alcaro, F. Blanc, F. Barbetti, M. Fleury, E. Peroni, P. Rovero, G. Rudolf, F. Lolli, E. Trifilieff, A.M. Papini, J. de Seze. (2010). Evaluation of New Immunological Targets in Neuromyelitis Optica. . NEUROLOGY, vol. 74(9S2), P-A390, ISSN: 0028-3878. [P156] F Nuti, F. Real-Fernández, M. A Bonache, M Boccalini, S Chimichi, M Chelli, AM. Papini Microwave-assisted reaction of building blocks for glycopeptides synthesis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P0 [P157] F. Rizzolo, F. Nuti, S. Pandey, M. Chelli, P. Rovero, and AM. Papini Microwave-assisted solid phase synthesis of [Asn641(Glc)]FAN(635-655): a new case study for optimisation of glycopeptide synthesis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P106.

[P158] M. Scrima, P. Rovero, A.M. Papini, M. Chorev, A.M. D'Ursi. Molecular dynamics calculation and NMR conformational studies of heterodetic triazolyl cyclo-nonapeptides: a comparative study. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P144. [P159] S. Pandey, E. Peroni, MC Alcaro, F. Rizzolo, F. Nuti, M. Chelli, S Matà, P. Rovero, F. Lolli, AM. Papini. Mimicry effect of the neo-epitope [Asn641(Glc)]FAN(635-655) with CSF114(Glc) detecting autoantibodies in Multiple Sclerosis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract O1. [P160] S. Pandey, D. Lambardi, F. Real Fernández, M. C. Alcaro, I. Doni, E. Peroni, M. Chelli, F. Lolli, A.M. Papini, P. Rovero. Identification of cytoskeletal proteins monoclonal anbibodies recognized by CSF114(Glc), the synthetic probe of multiple sclerosis. Italian Proteomics Association, 5th annual national conference (ItPA), Firenze (Italy), 9-12 July, 2010. Abstract p.1.59. [P161] F. Real-Fernández, I. Passalacqua, E. Peroni, F. Lolli, P. Rovero, A.M. Papini. A surface-plasmon resonance-based label-free in vitro serodiagnostic technology for multiple sclerosis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P403. [P162] F. Real-Fernández, I. Passalacqua, E. Peroni, F. Lolli, P. Rovero, A.M. Papini. Characterisation of the minimal epitope detecting autoantibodies in Multiple Sclerosis by surface plasmon resonance. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P404.

[P163] S. Pandey, D. Lambardi, M.C. Alcaro, F. R. Fernández, E. Peroni, P. Rovero, M. Chelli, F. Lolli, A.M. Papini. Identification of cytoskeletal proteins monoclonal antibodies recognized by CSF114(Glc), the synthetic probe of Multiple Sclerosis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P206. [P164] C. Testa, F. Nuti, M. Scrima, A.M. D’Ursi, N. Lubin-Germain, M. Chorev, P. Rovero, A.M. Papini. Stabilization of beta- turn conformation in melanocortin like peptide by click reaction. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract O8. [P165] F. Rizzolo, C. Testa, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. Conventional and microwave-assisted SPPS approach: a comparative study of PTHrP(1-34)NH2 synthesis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P107.

[P166] S. Carganico, N. Zanella, G. Sabatino, P. Rovero, M. Chorev, A.M. Papini. A novel diagnostic-prognostic tool for diabetes: UPLC analysis of glycated metabolites. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P379. [P167] M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, C. Tiberti, A.M. Papini.Celiac disease: characterization of linear autoantigenic epitopes. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P399. [P168] G. Sabatino, M. Di Pisa, M. Chelli, P. Rovero, C. Tiberti, and A. M. Papini. Celiac disease: characterization of amino acids/short peptides finger print for a fast I.V.D. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P400. [P169] L.M. Lumini, G. Cane, A. Di Cianni, A.M. Papini, and M. Ginanneschi. A study on the microwaves synthesis of the somatostatin dicarba-analogues. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P105

[P170] F. Nuti, F. Rizzolo, F. Gori, M. Chelli, P. Rovero, L. Moroder, A.M. Papini. Microwave-assisted solid phase synthesis of collagen peptides. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P110

[P171] F. Gori, B. Mulinacci, L. Massai, F. Lolli, A.M. Papini, P. Rovero. Antigenic probes for autoantibody detection in Multiple Sclerosis: synthetic peptides versus recombinant proteins. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P-405. [P172] S. Pandey, E. Peroni, P. Rovero, F. Lolli, M. Chelli, A. M. D’Ursi and A. M. Papini. Rational design and optimization of newly designed glycopeptide to develop the diagnostic/prognostic assays for Multiple Sclerosis. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P407. [P173] E. Peroni, N. Brodie Linder, A.M. Papini. On-silica peptide probes: innovative in vitro diagnostic devices for detection of antibodies as biomarkers of autoimmune diseases. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P471.

[P174] P. Fantini, M.C. Alcaro, I. Paolini, F. Barbetti, D. Valoriani, A.M. Papini, F. Lolli, P. Rovero, F. Pratesi, P. Migliorini. The 'Chemical Reverse Approach' to identify autoantibodies in Systemic Lupus Erithematosus patients. 31st European Peptide Symposium, Copenhagen (Denmark), September 5-9, 2010. Abstract P398.

2011

[P175] Testa, C., Carganico, S., Scrima, M., D’Ursi, A.M., Germain, N.L., Chorev, M., Rovero, P., and Papini, A.M.. Biological studies of synthesized homologues of melanocortin hormones 2nd PhD Day, University of Florence, Sesto Fiorentino, Florence (Italy), 18 May 2011 [P176] ME Street, A.M Papini, C. Testa, F. Nuti, E. Grossi, S Bernasconi Relationships between urinary concentrations of PHTALOX, obesity and insulin sensitivity in obese children: a pilot study. The Obese Species workshop, Erice Italy 21-26 October 2011. [P177] F. Real-Fernández, F. Nuti, M.Angeles Bonache, M. Boccalini, S. Chimichi, M. Chelli, and AM. Papini. Controlled microwave-assisted coupling reaction to obtain glycosylated aspartic acid. International Microwave-Assisted Organic and Peptide Synthesis Symposium, Firenze (Italy), April 27-29, 2011 Abstract PP-9 [P178] Y. Cao, C. Tiberi, F. Nuti, E. Peroni, J.Uziel, and A.M. Papini. A convergent microwave-assisted approach for solid-phase synthesis of O-glycopeptide sequences. International Microwave-Assisted Organic and Peptide Synthesis Symposium, Firenze (Italy), April 27-29, 2011 Abstract PP-12.

[P179] M Di Pisa, G Sabatino, M Chelli,P. Rovero,and A.M. Papini Characterization of linear autoantigenic epitopes in CeliacDisease MW assisted and conventional solid phase synthesis. International Microwave-Assisted Organic and Peptide Synthesis Symposium, Firenze (Italy), April 27-29, 2011 Abstract PP-14

[P180] G. Cane, M. Lumini, A.M. Papini and M. Ginanneschi Microwave-assisted RCM in the synthesis of Somatostatin dicarba-analogues. A case study MW assisted and conventional solid phase synthesis. International Microwave-Assisted Organic and Peptide Synthesis Symposium, Firenze (Italy), April 27-29, 2011 Abstract PP-10

[P181] G. Sizun-Thome, G.Sabatino, B.Gatto, E. Peroni, Paolo Rovero, A.M. Papini.Solid-phase synthesis of NCp7(12-55) peptide: a comparison between MW assisted and conventional solid phase synthesis. International Microwave-Assisted Organic and Peptide Synthesis Symposium, Firenze (Italy), April 27-29, 2011 Abstract PP-11 [P182] O. Monasson C. Rentier, F. Rizzolo, E. Peroni, and A.M. Papini. Microwave-assisted solid-phase synthesis of peptide probes to detect specific biomarkers: shifting off limitations affecting conventional synthetic strategies. International Microwave-Assisted Organic and Peptide Synthesis Symposium, Firenze (Italy), April 27-29, 2011 Abstract PP-13 [P183] F. Rizzolo, C. Testa, M. Chorev, M. Chelli, P. Rovero, A. M. Papini, Conventional and microwave-assisted SPPS of PTHrP(1-34)NH2 - A comparative study. 2nd International Microwave-Assisted Organic and Peptide Synthesis Symposium, MAOPS2, Florence (Italy), 27-29 April 2011. Abstract FP-4

[P184] I. Friligou1, F. Rizzolo , T Tselios, J Matsoukas, P Rovero, and A.M. Papini Protocol for Microwave-Assisted Convergent and Divergent Synthesis of Multiple Antigen Peptide Systems (MAPs) 2nd International Microwave-Assisted Organic and Peptide Synthesis Symposium, MAOPS2, Florence (Italy), 27-29 April 2011. Abstract FP-6

2012

[P185] Testa, C., D’Addona, D., Scrima, M., D’Ursi, A.M., Dirain, M.L., Chorev, M., Haskell-Luevano, C., Rovero, P., Papini, A.M. SAR studies of triazolyl-containing cyclopeptides: A defined β-turn structure increases potency and selectivity to melanocortin receptor subtypes. 32nd European Peptide Symposium, Athens (Greece), 2-7 September 2012. Abstract-P-301

[P186] Rentier, C., Nuti, F., Monasson, O., Rossi, G., Pacini, G., Sabatino, G., Rovero, P., Papini, A.M. Post-translationally modified peptides for diagnostics and follow-up of autoimmune diseases. University of Florence 1st year Ph.D. students (cycle XXVII), Florence, (Italy), December 17 2012 [P187] Larregola, M., Pacini, G., Rizzolo, F., Burlina, F., Lavielle, S., Rovero, P., Papini, A.M. Towards semi-synthetic N-glucosylated MOG to identify aberrantly modified native protein autoantigens in multiple sclerosis 2nd Austrian Peptide Symposium, Vienna (Austria), November 29 2012 [P188] Rentier, C., Monasson, O., Nuti, F., Traldi, P., Lapolla, A., Larregola, M., Rovero, P., Papini, A.M. Synthesis of post-translationally modified peptides for detection of autoantibodies in diabetic patients’ sera 32nd European Peptide Symposium, Atene (Grecia),Settembre 2-7, 2012. Abstract P-032 [P189] Cao, Y., Nuti, F., Rossi, G., Uziel, J., Rovero, P., Papini, A.M. Synthesis of peptides and sulfated monosaccharides able to identify antibodies in IgM monoclonal gammopathy 32nd European Peptide Symposium, Athens (Greece), September 2-7, 2012 Abstract P-118.

[P190] Y. Cao, F. Nuti, C. Tiberi, J. Uziel, P. Rovero, A.M. Papini. Synthesis of building blocks for the synthesis of glycopeptides to detect anti-ganglioside antibodies in Amyotrophic Lateral Sclerosis. 32nd European Peptide Symposium, Athens (Greece), September 2-7, 2012 Abstract P-117. [P191] Nuti, F., Real-Fernandez, F., Pandey, S., Hayek, J., De Felice, C., Lavielle, S., Larregola, M., Rovero, P., Papini, A.M. Autoantibodies to N-glucosylated peptide sequons in Rett syndrome: the first insight to disclose an autoimmune mechanism 32nd European Peptide Symposium, Athens (Greece), September 2-7, 2012 Abstract P-218

[P192] Rentier, C., Nuti, F., Pacini, G., Rovero, P., Selmi, C., Papini, A.M. Synthesis of diastereoisomeric modified amino acids derived from -lipoic acid for use in solid phase peptide synthesis 32nd European Peptide Symposium, Athens (Greece), September 2-7, 2012 Abstract-P-362. [P193] Larregola, M., Pacini, G., Rizzolo, F., Burlina, F., Lavielle, S., Rovero, P., Papini, A.M. Towards semi-synthetic N-glucosylated MOG to identify aberrantly modified native protein autoantigens in multiple sclerosis 32nd European Peptide Symposium, Athens (Greece), September 2-7 2012 Abstract-P-119 [P194] Monasson, O., Rizzolo, F., Traldi, P., Lapolla, A., Papini, A.M. Design and synthesis of new peptide scaffold presenting AGEs as diagnostic tool to monitor biomarkers in diabetes 32nd European Peptide Symposium, Athens (Greece), September 2-7 2012 Abstract-P-339 [P195] Rizzolo, F., Testa, C., Lambardi, D., Chorev, M., Chelli, M., Rovero, P., Papini, A.M.. Fast and efficient microwave-assisted monitoring of difficult peptide sequences. 32nd European Peptide Symposium, Athens (Greece), September 2-7 2012 Abstract-P-202

[P196] C. Tiberi, G. Sabatino, M. Di Pisa, P. Rovero, A.M. Papini. SPPS of glucosylated multiple antigen peptides (MAPs) as synthetic probes for detection of autoantibodies in multiple sclerosis patients’ sera. 32nd European Peptide Symposium, Athens (Greece), September 2-7 2012 Abstract-P-359

[P197] M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, A.M. Papini. (2012). Synthesis of newly designed peptides for the diagnosis of Celiac Disease. 32nd European Peptide Symposium, Athens (Greece), September 2-7 2012 Abstract-P-364.

[P198] G. Sabatino, F. Di Pisa, M. Potenza, L. Dei, A.M. Papini. (2012). UPLC-based amino acid analysis of paintings and statistical analysis of chromatographic profiles for conservation of cultural heritage. 32nd European Peptide Symposium, Athens (Greece), September 2-7 2012, Abstract-P-373. [P199] Larregola, M., Papini, A.M. The importance of a “Chemical Reverse Approach” to detect biomarkers of immune-mediated diseases. 13th Naples Workshop on Bioactive Peptides, Naples (Italy), June 7-10 2012 [P200] Larregola, M., Papini, A.M. “Chemical Reverse Approach” to detect biomarkers of immune-mediated diseases. 3rd ERI-ICP conference "Death, Danger, Inflammation and Immunity", Institut Pasteur, Paris (France), May 31-June 1 2012 [P201] Larregola, M., Papini, A.M. The importance of a “Chemical Reverse Approach” to detect biomarkers of immune-mediated diseases. Gordon Research Conference on Peptides, Chemistry & Biology, Ventura, CA (USA), February 19-24 2012

[P202] A. Pratesi, C. Gabbiani, M. Ginanneschi, A.M. Papini, L. Messori Reactions of Cytotoxic Gold(I) and Gold(III) Complexes with the Active Site of Thioredoxin Reductase. Atti del 12th Workshop on PharmacoBioMetallics – BIOMET12, pag. 71 – P15, Padova, 26-28 Ottobre 2012.

2013 [P203] C. Rentier. and A.M. Papini Synthesis of modified peptides to set-up diagnostic tests for autoimmune diseases. Presentation session for “Les Doctoriales”, Vélizy-Villacoublay (France), June 17, 2012. [P204] C. Rentier, O. Monasson, F. Nuti, E. Peroni, G. Pacini, G. Rossi, M. Larregola, P. Rovero, and A.M. Papini Synthesis of lipoylated lysines ready for SPPS to be used as post-translational modifications in peptidomimetics for immune-related diseases diagnostics. Journées de Chimie Organique de la Societé Chimique de France 2013, Ecole Polytechnique, Palaiseau (France), September 24-26, 2013. Abstract P278, pag. 380. [P205] C. Rentier, F. Nuti, E. Peroni, G. Pacini, P. Rovero, and A.M. Papini. Preparation of peptide-resin conjugates to remove pathogenic antibodies from autoimmune diseases patients’ sera: the case of Primary Biliary Cirrhosis. PepMat 2013, October 28-31, 2013, Sorrento (Italy). Abstract P37. [P206] M. Di Pisa, G. Sabatino, P. Rovero, and A.M. Papini. Epitope mapping of N-terminal portion of tissue transglutaminase protein antigen to identify linear epitopes in coeliac disease. 18ème GFPP, Sète (France), 26-31 May 2013.

[P207] N. Auberger, M. Di Pisa, M. Larregola, O. Lequin, E. Peroni, A.M. Papini, G. Chassaing, J.M. Mallet, and S. Lavielle. Synthesis of new cyclo(glyco)peptides for the diagnosis of autoimmune diseases. 18ème GFPP, Sète (France), 26-31 May 2013.

2014 [P208] C. Rentier, G. Pacini, G. Rossi, F. Nuti, E. Peroni, M. Larregola, C. Selmi, P. Rovero and A.M. Papini. Post-translationally modified peptides for diagnostics and follow-up of autoimmune diseases. Frontiers of Chemical Biology: investigating life with Chemistry, June 6th 2014, Paris (France). [P209] M. Di Pisa, N. Auberger, M. Larregola, G. Chassaing, E. Peroni, S. Lavielle, A.M. Papini, O. Lequin, J.-M. Mallet. Glaser Oxidative Coupling on Peptides: Stabilization of β-Turn Structure. PD04, RICT 2014, Rouen, 2-4 July 2014, Awarded with a Poster Prize by the SCT (Société de Chimie Thérapeutique).

Abstracts in J Pept Science or Biopolymers (Period 2008-2014)

2008

[A1] F. Real-Fernández , A. Colson, J. Bayardon, F. Nuti, E. Peroni, R. Meunier-Prest, F. Lolli, M. Chelli, C. Darcel, S. Jugé, and A.M. Papini. Electrochemical Glycopeptide Probes to Detect Autoantibodies in Multiple Sclerosis Patients’ Sera. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 136, ISSN: 1075-2617, doi: 10.1002/psc.1090 [A2] E. Innocenti, E. Peroni, F. Nuti, M. Chelli, P. Rovero, C. Selmi, A.M.Papini. Post translational modified peptide-based ELISA to detect autoantibodies in Primary Biliary Cirrhosis.

[A3] A.M. Papini (2008). Zervas Award Memorial Lecture. Peptide-based immunoassays for biomarkers detection: A challenge for translational research. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 8, ISSN: 1075-2617, doi: 10.1002/psc.1088.

[A4] Le Chevalier Isaad, M. Scrima, S. Cantel, J. Levy, P. Rovero, A.M. D'Ursi, M. Chorev, A.M. Papini (2008). Synthesis and conformational analysis of a series of cyclic i-to-i+4 side chain-to-side chain 1,4-disubstituted [1,2,3]triazolyl-bridged PTHrP(11-19) derivatives JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(8S), p. 3, ISSN: 1075-2617, doi: 10.1002/psc.1073. [A5] F. Rizzolo, G. Sabatino, E. Perugia, M. Fridkin, M. Chelli, P. Roveroand A.M. Papini. Microwave-assisted solid-phase synthesis of peptideprobes to detect specific biomarkers: shifting off limitationsaffecting conventional synthetic strategies. 30th European PeptideSymposium, 31 August -5 September 2008, Helsinki, Finland.

[A6] F. Nuti, N. Qvit, F. Rizzolo, M. Hurevich, A. Carotenuto, E. Peroni,M. Chelli, P. Rovero, C. Gilon and A.M. Papini. Microwave-assistedsolid phase synthesis of backbone cyclic glycopeptide libraries. 30thEuropean Peptide Symposium, 31 August -5 September 2008, Helsinki,Finland. Abstract. JOURNAL OF PEPTIDE SCIENCE (2008), vol. 14(S), p. 131, ISSN: 1075-2617, doi: 10.1002/psc.1090 [A7] G. Sabatino, F. Rizzolo, B. Kolesińska, M. Chelli, P. Rovero, Z. J. Kamiński, and A.M. Papini.Microwave-assisted attachment of Fmoc-amino acids to resins viatriazine “superactive esters”. 30th European Peptide Symposium, 31August -5 September 2008, Helsinki, Finland. [A8] A. Di Cianni, D. D’Addona, F. Rizzolo, A.M. Papini, and M. Ginanneschi. On-resin microwaves-assisted Ring Closing Metathesis for the synthesis of Octreotide dicarba-analogues. 30th European Peptide Symposium, Helsinki (Finland), August 31-September 5, 2008, J. Pept. Sci. 14(Suppl), P20104-012, 83.

2010 [A9] F Nuti, F. Real-Fernández, M. A Bonache, M Boccalini, S Chimichi, M Chelli, AM. Papini Microwave-assisted reaction of building blocks for glycopeptides synthesis. [A10] F. Rizzolo, I. Bartolini, F. Nuti, S. Pandey, M. Chelli, P. Rovero, and AM. Papini Microwave-assisted solid phase synthesis of [Asn641(Glc)]FAN(635-655): a new case study for optimisation of glycopeptide synthesis. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 78, ISSN: 1075-2617, doi:10.1002/psc.1303 [A11] M. Scrima, P. Rovero, A.M. Papini, M. Chorev, A.M. D'Ursi. Molecular dynamics calculation and NMR conformational studies of heterodetic triazolyl cyclo-nonapeptides: a comparative study. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 91-92, ISSN: 1075-2617, doi: 10.1002/psc.1303 [A12] S. Pandey, E. Peroni, MC Alcaro, F. Rizzolo, F. Nuti, M. Chelli, S Matà, P. Rovero, F. Lolli, AM. Papini. Mimicry effect of the neo-epitope [Asn641(Glc)]FAN(635-655) with CSF114(Glc) detecting autoantibodies in Multiple Sclerosis. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 26, ISSN: 1075-2617, doi: 0.1002/psc.1301. [A13] S. Pandey, D. Lambardi, F. Real Fernández, M. C. Alcaro, I. Doni, E. Peroni, M. Chelli, F. Lolli, A.M. Papini, P. Rovero. Identification of cytoskeletal proteins monoclonal anbibodies recognized by CSF114(Glc), the synthetic probe of multiple sclerosis. Italian Proteomics Association, 5th annual national conference (ItPA), Firenze (Italy), 9-12 July, 2010. Abstract p.1.59. [A14] F. Real-Fernández, I. Passalacqua, E. Peroni, F. Lolli, P. Rovero, A.M. Papini. A surface-plasmon resonance-based label-free in vitro serodiagnostic technology for multiple sclerosis. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 177, ISSN: 1075-2617, doi: 10.1002/psc.1303 [A15] F. Real-Fernández, I. Passalacqua, E. Peroni, F. Lolli, P. Rovero, A.M. Papini. Characterisation of the minimal epitope detecting autoantibodies in Multiple Sclerosis by surface plasmon resonance. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 177-178, ISSN: 1075-2617, doi: 10.1002/psc.1303 [A16] S. Pandey, D. Lambardi, M.C. Alcaro, F. R. Fernández, E. Peroni, P. Rovero, M. Chelli, F. Lolli, A.M. Papini. Identification of cytoskeletal proteins monoclonal antibodies recognized by

CSF114(Glc), the synthetic probe of Multiple Sclerosis. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 112, ISSN: 1075-2617, doi: 10.1002/psc.1303 [A17] C. Testa, F. Nuti, M. Scrima, A.M. D’Ursi, N. Lubin-Germain, M. Chorev, P. Rovero, A.M. Papini. Stabilization of beta- turn conformation in melanocortin like peptide by click reaction. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 28-29, ISSN: 1075-2617, doi: 10.1002/psc.1301. [A18] F. Rizzolo, C. Testa, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. Conventional and microwave-assisted SPPS approach: a comparative study of PTHrP(1-34)NH2 synthesis. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 78-79, ISSN: 1075-2617, doi: 10.1002/psc.1303 [A19] S. Carganico, N. Zanella, G. Sabatino, P. Rovero, M. Chorev, A.M. Papini. A novel diagnostic-prognostic tool for diabetes: UPLC analysis of glycated metabolites. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 169, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A20] M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, C. Tiberi, A.M. Papini.Celiac disease: characterization of linear autoantigenic epitopes. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 176, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A21] G. Sabatino, M. Di Pisa, M. Chelli, P. Rovero, C. Tiberti, and A. M. Papini. Celiac disease: characterization of amino acids/short peptides finger print for a fast I.V.D. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 176, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A22] M. Lumini, G. Cane, A. Di Cianni, A.M. Papini, and M. Ginanneschi. A study on the microwaves synthesis of the somatostatin dicarba-analogues. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 78, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A23] F. Nuti, F. Rizzolo, F. Gori, M. Chelli, P. Rovero, L. Moroder, A.M. Papini. Microwave-assisted solid phase synthesis of collagen peptides. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 79, ISSN: 1075-2617, doi: 10.1002/psc.1303 [A24] F. Gori, B. Mulinacci, L. Massai, F. Lolli, A.M. Papini, P. Rovero. Antigenic probes for autoantibody detection in Multiple Sclerosis: synthetic peptides versus recombinant proteins. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 178, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A25] S. Pandey, E. Peroni, P. Rovero, F. Lolli, M. Chelli, A. M. D’Ursi and A. M. Papini. Rational design and optimization of newly designed glycopeptide to develop the diagnostic/prognostic assays for Multiple Sclerosis. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 178-179, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A26] E. Peroni, N. Brodie Linder, C. Alba-Simionesco, A.M. Papini. On-silica peptide probes: innovative in vitro diagnostic devices for detection of antibodies as biomarkers of autoimmune diseases. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 200, ISSN: 1075-2617, doi: 10.1002/psc.1303. [A27] P. Fantini, M.C. Alcaro, I. Paolini, F. Barbetti, D. Valoriani, A.M. Papini, F. Lolli, P. Rovero, F. Pratesi, P. Migliorini. The 'Chemical Reverse Approach' to identify autoantibodies in

Systemic Lupus Erithematosus patients. JOURNAL OF PEPTIDE SCIENCE (2010), vol. 16(S1), p. 175-176, ISSN: 1075-2617, doi: 10.1002/psc.1303.

2012 [A28] Testa, C. AND D'Addona, D. AND Scrima, M. AND D'Ursi, A.M. AND Dirain, M.L. AND Chorev, M. AND Rovero, P. AND Haskell-Luevano, C. AND Papini. A.M. (2012). SAR studies of triazolyl-containing cyclopeptides: A defined beta-turn structure increases potency and selectivity to melanocortin receptor subtypes. . JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S166-S167, ISSN: 1075-2617, doi: 10.1002/psc.2449 [A29] F. Rizzolo, C. Testa, D. Lambardi, M. Chorev, M. Chelli, P. Rovero, A.M. Papini. (2012). Fast and Efficient Microwave-Assisted Monitoring of Difficult Peptide Sequences.. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. 131-132, ISSN: 1075-2617, doi: 10.1002/psc.244 [A30] G. Sabatino, F. Di Pisa, M. Potenza, L. Dei, A.M. Papini. (2012). UPLC-based amino acid analysis of paintings and statistical analysis of chromatographic profiles for conservation of cultural heritage. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S191, ISSN: 1075-2617, doi: 10.1002/psc.2449 [A31] C. Rentier, O. Monasson, F. Nuti, P. Traldi, A. Lapolla, M. Larregola, P. Rovero, A.M. Papini. (2012). Synthesis of post-translationally modified peptides for detection of autoantibodies in diabetic patients' sera.. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. 68-69, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A32] F. Nuti, F. Real-Fernandez, S. Pandey, J. Hayek, C. De Felice, S. Lavielle, M. Larregola, P. Rovero, A.M. Papini. (2012). Autoantibodies to N-glucosylated peptide sequons in Rett syndrome: the first insight to disclose an autoimmune mechanism.. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. 137, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A33] C. Rentier, F. Nuti, G. Pacini, P. Rovero, C. Selmi, A.M. Papini. (2012). Synthesis of diastereoisomeric modified amino acids derived from lipoic acid for use in solid phase peptide synthesis . JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S187, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A34] M. Larregola, G. Pacini, F. Rizzolo, F. Burlina, S. Lavielle, P. Rovero, A.M. Papini. (2012). Towards semi-synthetic N-glucosylated MOG to identify aberrantly modified native protein autoantigens in multiple sclerosis.. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. 101, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A35] O. Monasson, F. Rizzolo, P. Traldi, A. Lapolla, A.M. Papini. (2012). Design and synthesis of new peptide scaffold presenting AGEs as diagnostic tool to monitor biomarkers in diabetes. . JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S180, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A36] M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, A.M. Papini. (2012). Synthesis of newly designed peptides for the diagnosis of Celiac Disease.. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S188, ISSN: 1075-2617, doi: 10.1002/psc.2449.

[A37] Y. Cao, F. Nuti, G. Rossi, J. Uziel, P. Rovero, A.M. Papini (2012). Synthesis of peptides and sulphated monosaccharides able to identify antibodies in IgM onoclonal gammopathy. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S100-S101, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A38] Y. Cao, F. Nuti, C. Tiberi, J. Uziel, P. Rovero, A.M. Papini (2012). Synthesis of building blocks for the synthesis of glycopeptides to detect anti-ganglioside antibodies in Amyotrophic Lateral Sclerosis. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S100, ISSN: 1075-2617, doi: 10.1002/psc.2449. [A39] A.M. Papini (2012). The mimicry pathway from anti-glycopeptide antibodies to specific protein antigens of immune-mediated neurodegenerative/neuroregressive diseases: the case study of Rett syndrome. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S23, ISSN: 1075-2617, doi: 10.1002/psc.2448. [A40] C. Tiberi, G. Sabatino, M. Di Pisa, P. Rovero, A.M. Papini. SPPS of glucosylated multiple antigen peptides (MAPs) as synthetic probes for detection of autoantibodies in multiple sclerosis patients’ sera. JOURNAL OF PEPTIDE SCIENCE, vol. 18(S1), p. S186, ISSN: 1075-2617, doi: 10.1002/psc.2448.

November 8, 2014

1

Period 1983-2003

Articles in peer-reviewed journals

1983-1990 [1] M. Taddei, A.M. Papini, M. Fiorenza, A. Ricci and G. Seconi. Ring opening reactions of thiiranes with group IVB organometallics: a new regioselective route to β-amino and β-cyanide thiols. Tetrahedron Lett. (1983) 24, 2311-2314. [2] A.M. Papini, A. Ricci, M. Taddei, G. Seconi and P. Dembech. Regiospecific Conversion of Oxiranes, Oxetanes, and Lactones into Difunctional Nitrogen Compounds via Aminosilanes and Aminostannanes. J. Chem. Soc. Perkin Trans. I (1984) 2261-2265. [3] M. Ginanneschi, A. Sertoli, A.M. Papini and G. Rapi. Chemical aspects of hapten-carrier interaction in contact allergy. Giorn. It. Derm. Vener. (1987) 122, 389-395. [4] S. Giuliani, R. Amann, A.M. Papini, C.A. Maggi and A. Meli. Modulatory action of galanin on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves. Eur. J. Pharmacol. (1989) 163, 91-96. [5] M. Ginanneschi, M. Chelli, A.M. Papini and G. Rapi. Highly efficient synthesis of steroid-17-spiro-5’-oxazolidine-2’,4’-diones from 17-keto steroids. Steroids (1990) 55, 501-506. [6] M. Chelli, G. Dupuis, S. Evangelista, M. Ginanneschi, A. Meli, A.M. Papini and G. Rapi. Suppression of the skin response to alantolactone in alantolactone-sensitized guinea pigs treated with N-acetyl-L-cysteinyl-L-alanine methyl ester. Eur. J. Med. Chem. (1990) 25, 107-115.

1991-1998 [7] R. von Grünigen, G. Siglmüller, A.M. Papini, K. Köcher, B. Traving, W. Göhring and L. Moroder. Enzyme Immunoassay with Captured Hapten. A sensitive Gastrin Assay with Biotinyl-Gastrin Derivatives. Biol. Chem. Hoppe-Seyler (1991) 372, 163-172. [8] A.M. Papini, S. Rudolph, G. Siglmüller, H.-J. Musiol, W. Göhring and L. Moroder. Alkylation of histidine with maleimido-compounds. Int. J. Pept. Prot. Res. (1992) 39, 348-355. [9] D. Donati, M. Ginanneschi, M. Chelli, G. Rapi and A.M. Papini. X-ray structure analysis of 3,11,17-trioxoandrostane-5α-carbonitrile and of 17α-ethoxycarbonyloxy-3-oxoandrost-4-ene-17-carbonitrile. Steroids (1992) 57, 502-506.

2

[10] L. Moroder, A.M. Papini, G. Siglmüller, K. Köcher, E. Dörrer and C.H. Schneider. Induction and Detection of Anti-Peptide Antibody Specificity Is Critically Affected by the Mode of Hapten Presentation. Biol. Chem. Hoppe-Seyler (1992) 373, 315-321. [11] M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani and G. Rapi. Cyclization of C-Terminal Histidine Peptides to 7-Amino-dihydroimidazo[1,5-c]pyrimidin-5-one Derivatives. J. Chem. Research (S) (1993) 118-119. [12] M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani, G. Rapi, E. Borghi, F. Laschi and M. Occhiuzzi. Complexation Properties of Histidyl-Glycyl-Containing Peptides. Part 1. Synthesis of cyclo(L-His-Gly)4 J. Chem. Research (S) (1993) 437-438 and J. Chem. Res.(M) (1993) 2929-2938. [13] E. Borghi, F. Laschi, M. Occhiuzzi, M. Chelli, M. Ginanneschi, A.M. Papini and G. Rapi. Complexation Properties of Histidyl-Glycyl containing Peptides. Part 2. An X-band EPR Study of Divalent Paramagnetic Metal Ions Interacting in Solution with H-(L-His-Gly)2-OMe. J. Chem. Research (S) (1994) 48-49. [14] D. Pinzani, A.M. Papini, M. Chelli, M. Ginanneschi, C.A. Maggi, R. Patacchini, L. Quartara and G. Rapi. Synthesis and biological activity of tachykinin analogs containing the adamantane moiety. Lett. Pept. Sci. (1995), 2, 307-313. [15] M. Ginanneschi, M. Chelli, A.M. Papini, D. Pinzani and G. Rapi. Structure of the adduct of Alantolactone with Z-L-Cys-L-Ala-OMe and 1H and 13C assignment of the Alantolactone moiety by 14 Tesla NMR. Magn. Reson. Chem. (1996) 34, 95-99. [16] D. Pinzani, A.M. Papini, M.E. Vallecchi, M. Chelli, M. Ginanneschi, G. Rapi, L. Quartara, R. Patacchini, C.A. Maggi and F.M. Arcamone. Glycosyl derivatives of NK2 tachykinin receptor antagonists. Bioorg. Med. Chem. Lett. (1996) 6, 367-372. [17] G. Giorgi, M. Ginanneschi, M. Chelli, A.M. Papini, F. Laschi and E. Borghi. Histidyl-Glycyl containing peptides. Characterization and complexation properties of H(L-His-Gly)2-R with hydrogen and alkali metal ions in the gas-phase. Rapid Commun. Mass Spectrom. (1996) 10, 1266-1272. [18] G. Caminati, A.M. Papini, S. Mazzucco and G. Gabrielli. Lipopeptides of myelin basic protein in mono- and multilayers. Thin Solid Films (1998) 327-329(1-2), 37-41. [19] M. Ciuffi, C. Cellai, S. Franchi-Micheli, P. Failli, L. Zilletti, M. Ginanneschi, M. Chelli, A.M. Papini and F. Paoletti. An in vivo, ex vivo and in vitro comparative study of activity of copper oligopeptide complexes vs Cu(II) ions. Pharmacol. Res. (1998) 38, 279-287.

1999

3

[20] S. Mazzucco, E. Nardi, M. Chelli, M. Ginanneschi, G. Rapi, A.M. Papini, M. Vergelli, B. Mazzanti, L. Massacesi and L. Amaducci. Synthesis of lipopeptides of the immunodominant epitope hMBP(83-99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response. Lett. Pept. Sci. (1999) 6, 51-59. [21] G. Sabatino, M. Chelli, S. Mazzucco, M. Ginanneschi and A M. Papini. Cyclisation of Histidine Containing Peptides in the Solid-Phase by Anchoring the Imidazole Ring to Trityl Resins. Tetrahedron Lett. (1999) 40(4), 809-812. [22] S. Mazzucco, S. Matà, M. Vergelli, R. Fioresi, E. Nardi, B. Mazzanti, M. Chelli, F. Lolli, M. Ginanneschi, F. Pinto, L. Massacesi and A.M. Papini. A Synthetic Glycopeptide of Human Myelin Oligodendrocyte Glycoprotein to Detect Antibody Responses in Multiple Sclerosis and Other Neurological Diseases. Bioorg. Med. Chem. Lett. (1999) 9(2), 167-172. [23] M. Casolaro, M. Chelli, M. Ginanneschi, F. Laschi, M. Muniz-Miranda, A.M. Papini and G. Sbrana. Spectroscopic and potentiometric study of copper(II) complexes with L-histidyl-glycyl-L-histidyl-glycine in aqueous solution. Spectrochim. Acta Part A, Mol. & Biomol. Spectroscopy (1999) 55(7-8), 1675-1689. [24] C. Galoppini, S. Meini, M. Tancredi, A. Di Fenza, A. Triolo, L. Quartara, C.A. Maggi, F. Formaggio, C. Toniolo, S. Mazzucco, A.M. Papini and P. Rovero. A new class of pseudopeptide antagonists of the kinin B1 receptor containing alkyl spacers. J. Med. Chem. (1999) 42(3), 409-414.

2001 [25] C. Giragossian, E. Nardi, C. Savery, M. Pellegrini, S. Meini, C.A. Maggi, A.M. Papini, and D. Mierke. Structural Characterization of Lipopeptide Agonists for the Bradykinin B2 Receptor. Biopolymers (2001) 58, 511-520. [26] A.M. Papini, B. Mazzanti, E. Nardi, E. Traggiai, C. Ballerini, T. Biagioli, H. Kalbacher, H. Beck, M. Deeg, M. Chelli, M. Ginanneschi, L. Massacesi, and M. Vergelli. Palmitoyl Derivatives of GpMBP Epitopes: T-Cell Response and Peptidases Susceptibility. J. Med. Chem. (2001) 44, 3504-3510. [27] F. Meyer, J. Uziel, A.M. Papini, and S. Jugé. Triphenylphosphonium salts bearing an L-alanyl substituents: short synthesis and enantiomeric analysis by NMR. Tetrahedron Lett. (2001) 42, 3981-3984. [28] A. Carotenuto, A.M. D’Ursi, E. Nardi, A.M. Papini, and P. Rovero. Conformational analysis of a glycosylated Human Oligodendrocyte Glycoprotein peptide epitope able to detect antibody response in Multiple Sclerosis. J. Med. Chem. (2001), 44, 2378-2381.

2002

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[29] E. Peroni, G. Caminati, P. Baglioni, F. Nuti, M. Chelli, and A.M. Papini. A New lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models. Bioorg. Med. Chem. Lett. (2002) 12, 1731-1734. [30] M. Casolaro, M. Chelli, M. Ginanneschi, F. Laschi, L. Messori, M. Muniz-Miranda, A.M. Papini, T. Kowalik-Jankowska, and H. Kozlowski. Spectroscopic and potentiometric study of the SOD mimic system Copper/Acetyl-L-histidyl-glycyl-L-histidyl-glycine. J. Inorganic Biochem. (2002) 89, 181-190. [31] A.M. Papini, E. Nardi, F. Nuti, J. Uziel, M. Ginanneschi, M. Chelli, and A. Brandi. Diastereoselective alkylation of Schiff bases for the synthesis of lipidic unnatural Fmoc-protected α-amino acids. Eur. J. Org. Chem. (2002) 16, 2736-2741. [32] C. Giragossian, S. Stone, A.M. Papini, L. Moroder, and D.F. Mierke. Conformational and molecular modeling studies of sulfated cholecystokinin-15. Biochem. Biophys. Res. Commun. (2002) 293, 1053-1059. [33] G. Sabatino, B. Mulinacci, M.C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini. Assessment of new 6Cl-HOBt based coupling reagents for peptide synthesis. Part 1: Coupling efficiency study. Lett. Pept. Sci. (2002) 9, 119-123.

2003 [34] G. Sabatino, M. Chinol, G. Paganelli, S. Papi, M. Chelli, G. Leone, A.M. Papini, A. De Luca, and M. Ginanneschi. A New Biotin Derivative-DOTA Conjugate as a candidate for pre-targeted diagnosis and therapy of tumors. J. Med. Chem. (2003) 46, 3170-3173. [35] M.C. Alcaro, M. Orfei, M. Chelli, M. Ginanneschi, and A.M. Papini. Solid-phase approach to the synthesis of cyclen derivatives from cyclotetrapeptides. Tetrahedron Letters (2003) 44, 5217-5219. [36] F. Meyer, A. Laaziri, A.M. Papini, J. Uziel, and S. Jugé. Efficient synthesis of β-halogeno protected L-alanines and their β-phosphonium derivatives. Tetrahedron Asymmetry (2003) 14, 2229-2238. [37] A.M. Papini, and P. Rovero. A combinatorial approach towards a diagnostic tool for MS. Speciality Chemicals Magazine (2003) 23(7), 26-27. Chem. Abs., 2003, 140, 355261. [38] M.C. Alcaro, E. Peroni, P. Rovero, and A.M. Papini. Synthetic peptides in the diagnosis of HIV infection. Current Protein and Peptide Science (2003) 4, 285-290. Chem. Abs., 2003, 139, 212483. [39] F. Lolli, B. Mazzanti, P. Rovero, and A.M. Papini. Synthetic peptides in the diagnosis of neurological diseases. Current Protein and Peptide Science (2003) 4, 277-284. Chem. Abs., 2003, 140, 283516.

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Peer-reviewed articles published in books

1993-2000 [101] M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani and G. Rapi. Cyclization of histidine azide: A side reaction during peptide synthesis. In: Peptides 1992, C.H. Schneider and A.N. Eberle eds., Escom Science Publishers B.V., Leiden, (1993) pp. 255-256. Pubblicato a Leiden, Olanda, 1993. Chem. Abs., 1994, 121, 281171. [102] L. Quartara, G. Balacco, C.A. Maggi, P. Rovero, M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani and G. Rapi. Conformation-activity relationship on MEN 10376 neurokinin A antagonist: Effect of cyclization. In: Peptides 1992, C.H. Schneider and A.N. Eberle eds., Escom Science Publishers B.V., Leiden, The Netherlands, (1993) pp. 591-592. Pubblicato a Leiden, Olanda, 1993. Chem. Abs., 1994, 121, 222201. [103] L. Moroder, K. Köcher, A.M. Papini, M. Dufresne and C.H. Schneider. The mode of Peptide-Antigen Presentation Critically Affects The Specificity of Both Immune Response and Antigen-Antibody Recognition. In: Chemistry of Peptides and Proteins, (1993) Vol. 5/6, part B, D. Brandenburg, V. Ivanov and W. Voelter eds., Verlag Mainz, Aachen, pp. 783-791. Pubblicato a Aachen, Germania, 1993. Chem. Abs., 1994, 121, 298655. [104] D. Pinzani, A.M. Papini, M.E. Vallecchi, M. Chelli, M. Ginanneschi, C.A. Maggi, R. Patacchini, M. Astolfi, L. Quartara, F.M. Arcamone and G. Rapi. Synthesis and biological activities of glycopeptides of NK2 receptor antagonists. In: Peptides: Chemistry, Structure and Biology P.T.P. Kaumaya and R.S. Hodges eds., Mayflower Scientific Ltd., Kingswindford, U.K. (1996) pp. 649-650. Pubblicato a Kingswindford, West Midlands, Gran Bretagna, 1996. Chem. Abs., 1996, 126, 26939. [105] A.M. Papini, S. Mazzucco, R. Fioresi, E. Nardi, M. Ginanneschi, M. Chelli, S. Matà, F. Lolli, F. Pinto, B. Mazzanti, L. Massacesi and M. Vergelli. [Asn31(N-β-D-Glucopyranosyl)]hMOG(30-50): an antigen to identify anti-hMOG peptide antibodies in multiple sclerosis patients. In: Proceedings of the 10th International Congress of Immunology, New Delhi, India, 1-6 November 1998, Monduzzi Editore, International Proceedings Division Bologna, Italy, Ottobre 1998, pp. 1239-1244. ISBN 88-323-1101-1. [106] A.M. Papini, S. Mazzucco, E. Nardi, M. Chelli, M. Ginanneschi and G. Rapi. Fmoc-2-aminopalmitic acid for the synthesis of lipopeptides with an hydrophobic chain on a C-C bond. In: Peptides: Frontiers of Peptide Science, James P. Tam and Pravin T.P. Kaumaya (Eds.) Kluwer/Escom Academic Publishers, Dordrecht/Boston/London, The Netherlands (1999) pp. 345-346. Chem. Abs., 1999, 131, 200040.

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[107] A.M. Papini, S. Mazzucco, D. Pinzani, M. Biondi, M. Chelli, M. Ginanneschi, G. Rapi, B. Mazzanti, M. Vergelli, L. Massacesi and L. Amaducci. Lipoderivatives of an immunodominant epitope of myelin basic protein increased T cell responsiveness in Lewis rats. In: Peptides: Frontiers of Peptide Science, James P. Tam and Pravin T.P. Kaumaya (Eds.) Kluwer/Escom Academic Publishers, Dordrecht/Boston/London, The Netherlands (1999) pp. 700-702. Chem. Abs., 1999, 131, 227631 [108] S. Mazzucco, E. Nardi, M. Chelli, M. Ginanneschi, E. Traggiai, M. Vergelli, B. Mazzanti, G. Rapi, L. Massacesi and A.M. Papini. Comparison of the T Cell Proliferative Response to Lipopeptides of the Immunodominant Epitopes hMBP(83-99) and hMBP(141-160). In: Peptides 1998, S. Bajusz and F. Hudecz (Eds.), Akadémiai Kiadò, Budapest (1999) pp. 604-605. Chem. Abs., 2000, 134, 41080 [109] S. Mazzucco, R. Fioresi, S. Matà, M. Vergelli, M. Chelli, F. Lolli, M. Ginanneschi, F. Pinto, B. Mazzanti, L. Massacesi, G. Rapi and A.M. Papini. Glycopeptides of hMOG(30-50) Detect Antibody Response in Multiple Sclerosis and other Neurological Diseases. In: Peptides 1998, S. Bajusz and F. Hudecz (Eds.), Akadémiai Kiadò, Budapest (1999) pp. 46-47. Chem. Abs., 2000, 133, 361706 [110] A.M. Papini, E. Nardi, S. Mazzucco, B. Mazzanti, E. Traggiai, C. Ballerini, H. Kalbacher, H. Beck, M. Chelli, M. Ginanneschi, L. Massacesi and M. Vergelli. Lipophilic modifications of peptide epitopes: T-cell response and susceptibility to peptidases. In: Peptides for the New Millenium G.B. Fields, J.P. Tam and G. Barany, Kluwer/Escom academic publishers, Dordrecht/Boston/London, The Netherlands (2000) pp.697-699. Chem. Abs., 2001, 135, 59864. [111] E. Nardi, S. Mazzucco, S. Matà, M. Chelli, B. Mazzanti, E. Traggiai, M. Ginanneschi, F. Pinto, L. Massacesi, M. Vergelli, H. Kalbacher, F. Lolli and A.M. Papini. Recombinant MOG from baculovirus inhibits anti-hMOG(30-50) antibodies by the synthetic antigen [Asn31(Glc)]hMOG(30-50). In: Peptides for the New Millenium G.B. Fields, J.P. Tam and G. Barany, Kluwer/Escom academic publishers, Dordrecht/Boston/London, The Netherlands (2000) pp. 708-709. Chem. Abs., 2001, 135, 60022.

2001 [112] A.M. Papini, E. Nardi, B. Mazzanti, T. Biagioli, E. Traggiai, M. Chelli, M. Ginanneschi, H. Kalbacher, L. Massacesi, and Marco Vergelli. Effect of lipoconjugation on MBP peptide epitopes for CD4+ T cell responsiveness. In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 69-70. Chem. Abs., 2003, 140, 161980. [113] J. Uziel, M.C. Alcaro, G. Sabatino, A. Di Fenza, M. Ginanneschi, M. Chelli, P. Rovero, and A.M. Papini. Constrained head-to-tail cyclopeptides by amino acid side chain anchoring to trityl resins. In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 285-286. Chem. Abs., 2003, 140, 199689

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[114] M.C. Alcaro, A.M. Papini, M. Chelli, D.Fishlock, C. Atkins, and G.A. Lajoie. Stereoselective syntheses of β,γ-unsaturated amino acids. In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 359-360, Chem. Abs., 2003, 140, 164146. [115] Carotenuto, A.M. D’Ursi, E. Nardi, E. Mastrangelo, A.M. Papini, and P. Rovero. Conformational studies on a glycopeptide of the human Myelin Oligodendrocyte Glycoprotein. In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 469-470. Chem. Abs., 2003, 140, 212640. [116] E. Nardi, E. Mastrangelo, S. Matà, B. Mazzanti, V. Zipoli, M. Chelli, M. Ginanneschi, L. Massacesi, M. Vergelli, F. Lolli, F. Pinto, and A.M. Papini. Study of the role of the glycosyl moiety in autoantibody recognition in Multiple Sclerosis. In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 895-896, Chem. Abs., 2003, 139, 83847. [117] E. Nardi, M. Chelli, M. Ginanneschi, S. Meini, L. Quartara, M.R. Altamura, C.A. Maggi, F. Formaggio, C. Toniolo, Q.B. Broxterman, P. Rovero, and A.M. Papini. Lipophilic modifications of bradykinin agonists, In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 929-930. Chem. Abs., 2003, 140, 175310. [118] E. Peroni, G. Caminati, P. Baglioni, M. Chelli, and A.M. Papini. A new lipophilic fluorescent probe for interaction studies of bioactive lipopeptides with membrane models. In: Peptides 2000, J. Martinez ; J.-A. Fehrentz (Eds.), Editions EDK, Paris, France (2001) pp. 989-990, Chem. Abs., 2003, 140, 141967.

2002 [119] A. Carotenuto, A. Di Fenza, E. Nardi, A.M. Papini, and P. Rovero. Conformational studies of a glycopeptide recognized with high affinity by autoantibodies in Multiple Sclerosis. pag. 340-341. In: Peptides. The Wave of the Future. M. Lebl; R.A. Houghten (Eds.), American Peptide Society, San Diego, CA,USA (2001) pp. 340-341, Chem. Abs., 2002, 138, 380990.

2003

[120] M.C. Alcaro, G. Sabatino, M. Ginanneschi, M. Chelli, A. Di Fenza, P. Rovero, and A.M. Papini. A synthetic strategy toward constrained head-to-tail cyclopeptides. In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 16-17. Chem. Abs., 2004, 141, 28295.

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[121] M.C. Alcaro, T. Terzani, F. Nuti, M. Chelli, F. Machetti, L. Quartara, R. Patacchini, S. Meini, S. Giuliani, A. Brandi, P. Rovero, and A.M. Papini. New constrained amino acids for the study of the role of the basic residues in bradykinin antagonists. In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 18-19. Chem. Abs., 2004, 141, 28296. [122] F. Nuti, S. Cicchi, E. Peroni, M. de la Cruz Pozo-Carrero, B. Mazzanti, M. Pazzagli, F. Lolli, M. Chelli, A.M. Papini, and A. Brandi. Synthesis of new Fmoc-protected iminosugars to study the role of the glycosyl moiety in autoantibody recognition in autoimmune diseases. In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 238-239. Chem. Abs., 2004, 141, 52673. [123] G. Sabatino, B. Mulinacci, M.C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini. A comparative study of coupling reagents for automatic multiple peptide synthesizers. In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 272-273. Chem. Abs., 2004, 141, 28422. [124] B. Mulinacci, E. Peroni, G. Sabatino, B. Mazzanti, M. Pazzagli, M. de la Cruz Pozo-Carrero, M. Chelli, A. Carotenuto, P. Rovero, F. Lolli, and A.M. Papini. Towards rationally designed glycopeptide antigens recognizing autoantibodies in Multiple Sclerosis patients. In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 388-389. Chem. Abs., 2004, 141, 37314. [125] E. Peroni, F. Lolli, B. Mulinacci, F. Nuti, M. Chelli, P. Rovero, and A.M. Papini. Innovative biocompatible immunoadsorbents containing immobilized selective glycopeptide antigens for Multiple Sclerosis therapy, In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 584-585. Chem. Abs., 2004, 141, 37453. [126] A.M. Papini, B. Mulinacci, E. Peroni, G. Sabatino, M. Chelli, A. Carotenuto, P. Rovero, S. Matà, F. Lolli, CSF114(Glc): the glycopeptide detecting autoantibodies in Multiple Sclerosis. PepKit, the first diagnostic test to follow-up the disease activity. In: Peptides 2002, E. Benedetti; C. Pedone (Eds.), Edizioni Ziino, Castellammare di Stabia, Italie (2003) pp. 998-999. Chem. Abs., 2004, 141, 52674.

Other publications

[1] A.M. Papini. Sintesi di peptidi e loro Studio sotto il Profilo Chimico, Bio-farmacologico ed Immunologico. Tesi di Dottorato di Ricerca in Scienze Chimiche; Firenze, Roma (1990) 1-118.

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[2] A. Sertoli, P. Lombardi, S. Francalanci, M. Gola, P. Spallanzani, S. Giorgini, E. Panconesi, M. Ginanneschi, A.M. Papini and G. Rapi. L’Eczema da Contatto Professionale. Collana di monografie sulle malattie professionali. VI Supplemento della Rivista degli Infortuni e delle Malattie Professionali. Ed. I.N.A.I.L (1987) 1-153.

Invited Lectures

2001 [IL1] 2nd Conference “Medicinal Chemistry: Drug Design and Development”, Conference and Cultural Centre, University of Patras, Greece (Invitata dal Prof. J. Matsoukas), March 1-3, 2001. “Specific role of Asn(Glc) in autoantibody recognition to glycosylated peptides: towards new immunotherapeutic drugs for the treatment of Multiple Sclerosis”. 2002

[IL2] 3rd Conference“Medicinal Chemistry: Drug Design and Development”, Conference and Cultural Centre, University of Patras, Greece (Invitata da Prof. J. Matsoukas), March 7-9, 2002. “A very promising Cyclic MBP Peptide for Multiple Sclerosis” Memory Lecture in Honour of Marco Vergelli for his contributions to MS Research. [IL3] European Commission-funded Intensive Course: “Synthesis for Solving Biological Problems”, Henderson Hall, Newcastle upon Tyne, United Kingdom (Invitata dal Prof. B. Golding), August 3-10, 2002, August 3, h. 9.00. «Synthesis of post-translationally modified peptidesof myelin proteins. The contribution of bioorganic chemistry to the diagnosis and immunotherapy of the autoimmune disease multiple sclerosis ». [IL4] Simposio “I peptidi nella ricerca immunologica. Il contributo della chimica crganica alla ricerca biomedica”, Polo Scientifico, Università di Firenze, Dipartimento di Chimica Organica “Ugo Schiff”, Firenze, Italy, December 6, 2002, h. 17:45. “Presentazione di MS PepKit: il primo test per il follow-up della Slerosi Multipla”. 2003 [IL5] Institut de Biologie Moléculaire et Cellulaire, Strasbourg, Francia (Invitata dal Dr. J-P Briand) February 21, 2003, h. 9 :30, Salle des Séminaires. “CSF114(Glc): the glycopeptide detecting autoantibodies in multiple sclerosis. MS PepKit, the first diagnostic test to follow-up the disease activity”. [IL6] XXI Congresso Nazionale della Società Chimica Italiana, Divisione di Chimica dei Sistemi Biologici, Torino, Italia (Invitata dal Prof. G. Bonora) Giugno, 22-27, 2003, 24 Giugno, h. 11:00. “MS PepKit: the prototipe of the first test, based on the glycopeptide CSF114(Glc), to follow-up the disease activity in multiple sclerosis” [IL7] INSERM E209, Hôpital Saint-Antoine, Bâtiment Raoul, Paris, France (Invitata dal Dr. C. Carnaud) June 23, 2003, h. 11 :00. “Contribution of peptide chemistry to study the autoimmune disease multiple sclerosis”

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[IL8] Journée de l’Ecole Doctorale : Du Matériau à l’Interface Chimie-Biologie, Université de Paris-Sud, Paris, France (Invitata dal Prof. Y. Langlois), September 19, 2003, h. 9 :10, Bâtiment 338. “Contribution de le chimie bioorganique à l’étude d’une pathologie auto-immune : cas de la sclérose en plaque”. [IL9] 1st Pratical Training Course “Innovative combinatorial approaches and technologies”, ComGenex, Budapest, Hungary & Polo Scientifico, Università di Firenze, Firenze, Italy (Invitata dal Dr. F. Darvas, ComGenex, Budapest) April 9-11, 2003, April 11, h12:30. “A combinatorial approach for the rational design of innovative diagnostic tools for autoimmune diseases”. [IL10] Italian-German Mini Symposium on Peptides and Proteins. “Structure and Molecular Recognition”, Max Planck Institut für Biochemie, Martinsried, Germany (Invitata dal Prof. Dr. L Moroder) December 5, 2003, Kleiner Hoersaal, Bauteil T, h. 14:30. “Development of the innovative designed glycopeptide CSF114(Glc) as prognostic tool for the characterizationof an antibody-mediated multiple sclerosis subgroup”.

Oral Communications 1985-1991

[OC1] A.M. Papini and G. Dupuis. Anti-hapten monoclonal antibodies: attempts to produce anti- urushiol monoclonal antibodies in Balb/c mice. 6th Meeting GIRDCA, Torino (Italy), November 16, 1985. [OC2] L. Moroder, K. Köcher, A.M. Papini, M. Dufresne and C.H. Schneider. The mode of peptide-antigen presentation critically affects the specificity of both immune response and antigen-antibody recognition. 8th Symposium on Chemistry of Peptides and Proteins FRG-USSR, Aachen (Germany), September 29-October 3, 1991, L-49.

1996-2000 [OC3] A.M. Papini, S. Mazzucco, A. Franchi, M. Chelli, M. Ginanneschi, G. Rapi, R. Tosi, G. Greco, D. Fruci, R. Butler and L. Massacesi. Characterization of the T cell response to lipid bound and lipid free human myelin peptides in multiple sclerosis. Progress Report, First Project on Multiple Sclerosis, Istituto Superiore di Sanità, Roma (Italy), November 28-29, 1996, Reports ISTISAN, 96/32, 57-58. [OC4] A.M. Papini, M. Biondi, D. Pinzani, S. Mazzucco, M. Chelli, M. Ginanneschi, G. Rapi, B. Mazzanti, M. Vergelli, L. Massacesi and L. Amaducci. Lipoderivatives of an immunodominant epitope of myelin basic protein increased T cell responsiveness in Lewis rats. 15th American Peptide Symposium, Nashville (Tennessee, U.S.A.), June 14-19, 1997, Abstract L093, p. 2-47.

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[OC5] A.M. Papini, S. Mazzucco, E. Nardi, M. Chelli, M. Ginanneschi and G. Rapi. Fmoc-2-aminopalmitic acid for the synthesis of lipopeptides with an hydrophobic chain on a C-C bond. 15th American Peptide Symposium, Nashville (Tennessee, U.S.A.), June 14-19, 1997, (Mini Symposium) Abstract MS30, p. 2-67. [OC6] S. Mazzucco, E. Nardi, M. Chelli, A.M. Papini, M. Vergelli, B. Mazzanti and L.Massacesi. Labeled lipopeptides of myelin basic protein for the study of the molecular mechanism of multiple sclerosis. Forum Jeunes Chercheurs, Journée d’étude en chimie organique et chimie des materiaux, Université de Cergy-Pontoise (Neuville sur Oise), 25 Juin 1998, (Lecture) Abstract p. 20. [OC7] A.M. Papini, R. Fioresi, S. Mazzucco, S. Matà, F. Lolli, M. Vergelli, M. Chelli, M. Ginanneschi, G. Rapi, B. Mazzanti, L. Massacesi and F. Pinto. Glycopeptides of hMOG(30-50) detect antibody response in multiple sclerosis and other neurological diseases. 25th European Peptide Symposium, Budapest (Hungary), August 30-September 4, 1998 (Lecture) Abstract L22, p. 91; J. Peptide Sci. (1998), 4, ix. [OC8] F. Meyer, A. Laaziri, J. Uziel, A.M. Papini and S. Jugé. Nouvelle voie d’acces aux α-aminoesters β-halogénés ou phosphorés a partir d’oxazolines dérivées de la L-Sérine. Journées de Chimie Organique. Ecole Polytechnique -Palaiseau (France), 15-17 Septembre 1998. [OC9] A.M. Papini, R. Fioresi, S. Mazzucco, E. Nardi, S. Matà, F. Lolli, M. Vergelli, M. Chelli, M. Ginanneschi, B. Mazzanti, L.Massacesi and F. Pinto. Asn31[N-Glucosyl]hMOG(30-50): a useful antigen to identify anti-MOG antibodies in multiple sclerosis patients. 10th International Congress of Immunology, New Delhi (India), November 1-6, 1998, Interactive Workshop on Neuroimmunology and autoimmune disorders of CNS W-28. [OC10] L. Massacesi, B. Mazzanti, M. Vergelli, A.M. Papini, S. Mazzucco, M. Chelli, R. Tosi, R. Butler, G. Greco, D. Fruci. Caratterizzazione della risposta linfocitaria verso peptidi e lipopeptidi della mielina umana nella sclerosi multipla. Progress Report, Second research project on Multiple sclerosis, Istituto Superiore di Sanità, Roma (Italy), (1998), Rapporti ISTISAN, 98/7, 75-76. [OC11] F. Lolli, V. Zipoli, S. Matà, F. Pinto, L. Massacesi, E. Nardi, S. Mazzucco, M. Chelli, A.M. Papini, M. Vergelli. Intratechal synthesis of autoantibodies to a glycoderivative peptide of MOG in multiple sclerosis. X° National A.I.N.I. Congress, Associazione Italiana Neuroimmunologia, Florence (Italy), Novembre 15-16, 1999; Abstract A62, J. Neuroim. (1999) 31-33.

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[OC12] L. Massacesi, B. Mazzanti, M. Vergelli, A.M. Papini, S. Mazzucco, M. Chelli, R. Tosi, R. Butler, G. Greco, D. Fruci. Characterization of lymphocyte response to human myelin peptides and lipopeptides in multiple sclerosis. Second research project on Multiple sclerosis. Second year. Istituto Superiore di Sanità, Roma (Italy), (1999), Rapporti ISTISAN, 99/18, 85-88. [OC13] F.Meyer, H.Laaziri, J.Uziel, A.M.Papini and S.Jugé. Nouvelle voie d’accès aux acides α-aminés β-halogénés ou β-phosphorés à partir d’oxazolines dérivées de la sérine. Semaines d’Etude en Chimie Organique, SECO XXXVII, Houffalize (Belgique), 21-26 May, 2000. [OC14] A.M. Papini, E. Nardi, B. Mazzanti, T. Biagioli, E. Traggiai, M. Chelli, M. Ginanneschi, H. Kalbacher, L. Massacesi and Marco Vergelli. Effect of lipoconjugation on MBP peptide epitopes for CD4+ T cell responsiveness. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, Abstract OC18, J. Pept. Sci., Supplement to Vol. 6, 2000, S 63. [OC15] E. Nardi, S. Matà, V. Zipoli, E. Mastrangelo, M. Chelli, A.M. Papini, M. Vergelli, and F. Lolli. Ruolo del residuo glicosilico nel riconoscimento di autoanticorpi contro peptidi glicosilati della MOG. XI Congresso AINI (Associazione Italiana di Neuroimmunologia), Camogli (Italy), October 26-28, 2000, Abstract C38.

2002 [OC16] A. M. Papini, B. Mulinacci, E. Peroni, G. Sabatino, S. Matà, M. Chelli, A. Carotenuto, P. Rovero, F. Pinto, and F. Lolli. A glycopeptide detecting autoantibodies in multiple sclerosis: from a diagnostic test toward a selective therapeutic strategy. 27th European Peptide Symposium, Sorrento (Italy), August 31st-September 6th, 2002, J. Pept. Sci., 2002, 8(Suppl.), S70, Abstract L55. [OC17] A.M. Papini, F. Nuti, E. Nardi, E. Peroni, M. Chelli, B. Mazzanti, F. Lolli, J. Uziel, and A. Brandi. Sintesi di lipoamminoacidi eniantiomericamente puri per l’ottenimento di lipopeptidi come vaccini sintetici per la sclerosi multipla. XXVIII Convegno Nazionale della Divisione di Chimica Organica della S.C.I., Rome (Italie) 16-20 Septembre 2002, Abstract O16. [OC18] A.M. Papini, F. Nuti, E. Peroni, M. Chelli, B. Mazzanti, T. Biagioli, F. Lolli, and A. Brandi. Lipopeptide as synthetic vaccines in Multiple Sclerosis animal model: stereoselective synthesis of lipoaminoacids. Third Italian-French Meeting on Organic Chemistry. “Organic Chemistry towards Interfaces”, Pise (Italie), 20-23 Novembre, 2002, Abstract OC10.

2003

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[OC19] E. Peroni, F. Lolli, B. Mazzanti, M. Pazzagli, B. Bonetti, L. Massacesi, M. Chelli, P. Rovero, and A.M. Papini. Towards a therapeutic apheresis in Multiple Sclerosis based on a glycopeptide antigen able to isolate specific autoantibodies. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juillet, 2003, LY 1, Abstracts p. 277. [OC20] A.M. Papini, B. Mulinacci, E. Peroni, F. Nuti, G. Sabatino, M.C. Pozo-Carrero, B. Mazzanti, M. Pazzagli, L. Massacesi, M. Chelli, P. Rovero, and F. Lolli. MS PepKit:the first diagnostic test based on CSF114(Glc), a glycopeptide to follow-up Multiple Sclerosis. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juillet, 2003, O 62, Abstracts p. 298.

Poster Communications 1986-1990

[P1] A.M. Papini, M. Ginanneschi, G. Rapi and M. Chelli. Sintesi e struttura di addotti aptene-dipeptide: possibili agenti desensibilizzanti nelle dermatiti da contatto. 32° Congresso Nazionale della Società Italiana di Biochimica, Giardini Naxos, Messina (Italy), September 28-October 1, 1986, P-12. [P2] M. Ginanneschi, G. Rapi, M. Chelli and A.M. Papini. Sintesi di 17-spiro-5’-ossazolidin-2’,4’-dioni steroidi. Convegno Nazionale organizzato dalla Società Chimica Italiana, Divisione Chimica Organica: Giornate di Chimica delle Sostanze Naturali, Maratea (Italy), May 28-31, 1989, P-28. [P3] A.M. Papini, M. Chelli, M. Ginanneschi, G. Rapi and G. Dupuis. Studies on the mechanism of suppression of the skin response to alantolactone: conformational characterization of the adduct H- Cys(S-alantolactone)-Ala-OMe. Second Naples Workshop on Bioactive Peptides, organizzato dall’Università di Napoli Federico II, Capri (Italy), May 21-23, 1990, C-28, pag. 87.

1991-2000 [P4] A.M. Papini, M. Chelli, M. Ginanneschi, G. Rapi, E. Borghi, M. Occhiuzzi, F. Laschi and P. Rovero. Synthesis and physico-chemical studies of metal ion binding properties of histidyl-glycyl peptides as model compounds. Twelfth American Peptide Symposium; Massachusetts Institute of Technology, Cambridge, (Massachusetts, USA), June 16-21, 1991, P-158. [P5] L. Moroder, S. Rudolph and A.M. Papini. Intramolecular alkylation of histidine in maleoyl-peptides. Twelfth American Peptide Symposium; Massachusetts Institute of Technology, Cambridge, (Massachusetts, USA), June 16-21, 1991, P-416.

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[P6] E. Borghi, M. Chelli, M. Ginanneschi, F. Laschi, A.M. Papini, G. Rapi and P. Rovero. Studies on the interaction of linear histidyl-glycyl peptides with metal ions. 36° Congresso Nazionale della Società Italiana di Biochimica, organizzato dall’Università di Ferrara, Ferrara (Italy), September 10-13, 1991, p.14. Italian Biochemical Society Transactions (IBST) Mini-paper, (1991), 2, 14. [P7] M. Chelli, E. Borghi, M. Ginanneschi, F. Laschi, M. Occhiuzzi, A.M. Papini, D. Pinzani and G. Rapi. Interaction of Me2+ ion with linear L-histidyl-glycyl tetrapeptides by magnetic resonance techniques. 3rd Naples Workshop on Bioactive Peptides, organizzato dall’Università di Napoli Federico II, Capri (Italy), May 24-27, 1992, M-13, pp. 98-99. [P8] M. Chelli, M. Ginanneschi, A.M. Papini and G. Rapi. Side-reactions in liquid phase peptide synthesis: cyclization of histidine azide at room temperature. 22nd European Peptide Sympiosium, Interlaken (Switzerland), September 13-19, 1992, P-46. [P9] L. Quartara, C.A. Maggi, P. Rovero, M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani and G. Rapi. Neurokinin A (NKA) antagonists: studies on conformation-activity relationship of linear and cyclic heptapeptides. 22nd European Peptide Sympiosium, Interlaken (Switzerland), September 13-19, 1992, P-225. [P10] M. Chelli, M. Ginanneschi, C.A. Maggi, A.M. Papini, R. Patacchini, D. Pinzani, L. Quartara and G. Rapi. Synthesis and biological activity of tachykinin analogues containing hydrophobic moieties. Proteine 93, VII Convegno Nazionale, Parma (Italy), May, 26-28, 1993, E-63, p. 151. [P11] M. Chelli, M. Ginanneschi, C.A. Maggi, A.M. Papini, D. Pinzani, L. Quartara and G. Rapi. Pfp of adamantane acetic acid in the synthesis of tachykinin analogues containing hydrophobic moieties. 13th American Peptide Symposium, Edmonton (Alberta, Canada), June 20-25, 1993, P-413, p. 2-104. [P12] M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani, G. Rapi, P. Rovero, E. Borghi, M. Occhiuzzi and F. Laschi. The new model-peptide cyclo(L-His-Gly)4: comparative syntheses and magnetic resonance investigations on the interaction with divalent metal ions. II Convegno nazionale della Società Chimica Italiana, Divisione di Chimica dei Sistemi Biologici, Università «La Sapienza», Roma (Italy), December 9-11, 1993, pp. 78-79. [P13] E. Borghi, M. Occhiuzzi, F. Laschi, M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani, G. Rapi and P. Rovero. Histidyl-glycyl containing peptides: a spectroscopic characterization of Copper(II) interaction with the linear octapeptide H-(L-His-Gly)4-OH. Metal ions in Biological Systems, Eurobic II, Firenze (Italy), August 30-September 3, 1994, p. 61.

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[P14] E. Borghi, M. Occhiuzzi, F. Laschi, M. Chelli, M. Ginanneschi, A.M. Papini and G. Rapi. L-histidyl-glycyl containing linear and cyclopeptides. Comparative results for the interactions with Copper (II) ion. III Convegno nazionale della Società Chimica Italiana, Divisione di Chimica dei Sistemi Biologici, Università «La Sapienza», Roma (Italy), January 25-27, 1995, P-20. [P15] M. Chelli, M. Ginanneschi, A.M. Papini, D. Pinzani, G. Rapi, G. Giorgi, F. Laschi, E. Borghi and M. Occhiuzzi. Complexation properties of histidyl-glycyl containing peptides. A mass spectrometry study of H-(L-His-Gly)2-OMe cationized with metal ions. III Convegno nazionale della Società Chimica Italiana, Divisione di Chimica dei Sistemi Biologici, Università «La Sapienza», Roma (Italy), January 25-27, 1995, P-21. [P16] A.M. Papini, M. Biondi, D. Pinzani, M. Chelli, M. Ginanneschi, G. Rapi, B. Mazzanti, M. Vergelli, L. Massacesi and L. Amaducci. Sintesi di lipopeptidi dell’epitopo immunodominante della proteina basica della mielina nel ratto Lewis e caratterizzazione delle proprietà encefalitogene. III Convegno nazionale della Società Chimica Italiana, Divisione di Chimica dei Sistemi Biologici, Università «La Sapienza», Roma (Italy), January 25-27, 1995, P-48. [P17] G. Giorgi, M. Chelli, M. Ginanneschi, F. Laschi, A.M. Papini, D. Pinzani, E. Borghi, M. Occhiuzzi and G. Rapi. A Mass Spectrometry study of H-(L-His-Gly)2-OMe cationized with metal ions. 14th American Peptide Symposium, Columbus (Ohio, USA), June 18-23, 1995, P-262, p. 2-87. [P18] A.M. Papini, M. Biondi, D. Pinzani, S. Mazzucco, M. Chelli, M. Ginanneschi, G. Rapi, B. Mazzanti, M. Vergelli, L. Massacesi and L. Amaducci. Lipopeptides of the immunodominant epitope of myelin basic protein in Lewis rats and characterization of their encephalitogenic properties. 14th American Peptide Symposium, Columbus (Ohio, USA), June 18-23, 1995, P-444, p. 2-122. [P19] D. Pinzani, A.M. Papini, M.E. Vallecchi, M. Chelli, M. Ginanneschi, C.A. Maggi, R. Patacchini, M. Astolfi, L. Quartara and G. Rapi. Synthesis and biological activities of glycopeptides of NK2 receptor antagonists. 14th American Peptide Symposium, Columbus (Ohio, USA), June 18-23, 1995, P-586, p. 2-154. [P20] M. Ginanneschi, M. Chelli, A.M. Papini, D. Pinzani, G. Rapi, M. Ciuffi and L. Tarlini. In vitro radical scavenger activity of H-(L-His-Gly)2-OH Copper (II) complexes. 40° Congresso Nazionale della Società Italiana di Biochimica, Torino (Italy), September 12-15, 1995. Italian Biochemical Society Transactions (IBST) Mini-paper, (1995), 6, P-117.

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[P21] L. Tarlini, M. Ciuffi, S. Franchi-Micheli, S. Mugnai, L. Zilletti, M. Ginanneschi, M. Chelli, A.M. Papini, G. Rapi and F. Paoletti. Effect of H-(L-His-Gly)2-OH/Cu(II) complexes on in vitro, ex vivo, and in vivo models of tissue damage mediated by reactive oxygen species. Riunione congiunta monotematica sul metabolismo degli xenobiotici delle Società Italiane di Farmacologia e di Tossicologia, Siena (Italy), November 3-4, 1995, Poster p.65. [P22] A.M. Papini, S. Mazzucco, M. Chelli, M. Ginanneschi, G. Rapi, G. Caminati and G. Gabrielli. Conformational studies on lipopeptides of human myelin basic protein at the air-water interphase. 15th American Peptide Symposium, Nashville (Tennessee, USA), June 14-19, 1997, Abstract P220, p. 2-124. [P23] A. M. Papini, S. Mazzucco, E. Nardi, M. Chelli, M. Ginanneschi, B.Mazzanti, M. Vergelli, L. Massacesi, L. Amaducci and G. Rapi. Comparative study of the proliferative response of hMBP lipopeptides containing amide or C-C bond linked alkyl chains. 42° Congresso Nazionale della Società Italiana di Biochimica, Ancona (Italy), September 24-27, 1997. Italian Biochemical Society Transactions (IBST) Mini-paper, (1997), 9, P-8.10, p. 304. [P24] G. Caminati, G. Gabrielli, A.M. Papini, S. Mazzucco. Lipopeptides of myelin basic protein in mono and multilayer. LB8 International Conference on Langmuir-Blodgett Films, Asilomar, California USA, August 24-30, 1997. [P25] S. Mazzucco, E. Nardi, M. Chelli, M. Ginanneschi, G. Rapi, M. Vergelli, B. Mazzanti, E. Treggiai, L. Massacesi and A.M. Papini. Comparison of the T cell proliferative response to lipopeptides of hMBP(83-99) and hMBP(141-160) in multiple sclerosis patients. 25th European Peptide Symposium, Budapest (Hungary), August 30-September 4, 1998, Abstract P298, p. 8. [P26] S. Matà, F. Lolli, F. Pinto, S. Mazzucco, R. Fioresi, M. Chelli, M. Ginanneschi, A.M. Papini, B. Mazzanti, L. Massacesi and M. Vergelli. Antibodies to a glycopeptide of human MOG in multiple sclerosis and other neurological diseases. IX Congresso Nazionale AINI (Associazione Nazionale Neuroimmunologia), Chieti (Italy), October 28-30, 1998. [P27] B. Mazzanti, M. Vergelli, E. Traggiai, C. Ballerini, L. Massacesi, A.M. Papini, S. Mazzucco, D. Pinzani, M. Biondi, M. Chelli, M. Ginanneschi and G. Rapi. Lipoderivatives of an immunodominant epitope of myelin basic protein increased T cell responsiveness. IX Congresso Nazionale AINI (Associazione Italiana di Neuroimmunologia), Chieti (Italy), October 28-30, 1998. [P28] A.M. Papini, R. Fioresi, S. Mazzucco, E. Nardi, S. Matà, F. Lolli, M. Vergelli, M. Chelli, M. Ginanneschi, B. Mazzanti, L.Massacesi and F. Pinto. Asn31[N-Glucosyl]hMOG(30-50): a useful antigen to identify anti-MOG antibodies in multiple sclerosis patients. 10th International Congress of Immunology, New Delhi (India), November 1-6, 1998, Abstract P-189.

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[P29] G. Caminati, G. Gabrielli, S. Mazzucco and A.M. Papini. Caratterizzazione di peptidi all’interfase acqua aria. Congresso Nazionale di Chimica-Fisica 1998, Capo Taormina (Italy), September 1998, Abstract P30, p. 122-123. [P30] B. Anichini, M.C. Alcaro, L. Quartara, M.R. Altamura, M. Chelli, M. Ginanneschi and A.M. Papini. Synthetic pathways leading to protected 3,4-didehydroornithine for SPPS strategy. 16th American Peptide Symposium, Minneapolis (Minnesota, USA), June 26-July 1, 1999, Abstract P016. [P31] A.M. Papini, E. Nardi, S. Mazzucco, B. Mazzanti, E. Traggiai, C. Ballerini, H. Kalbacher, H. Beck, M. Chelli, M. Ginanneschi, L. Massacesi and M. Vergelli. T-Cell response to lipoderivatives of different MBP peptide antigens correlates with their suceptibility to peptidases. 16th American Peptide Symposium, Minneapolis (Minnesota, USA), June 26-July 1, 1999, Abstract P153. [P32] G. Sabatino, A. Di Fenza, M. Chelli, M. Ginanneschi, P. Rovero and A.M. Papini. Allyl esters of amino acids linked to trityl-resin by their side-chain as useful starting supports to obtain diketopiperazine based combinatorial libraries. 16th American Peptide Symposium, Minneapolis (Minnesota, USA), June 26-July 1, 1999, Abstract P220. [P33] E. Nardi, S. Mazzucco, S. Matà, M. Chelli, B. Mazzanti, E. Traggiai, M. Ginanneschi, F. Pinto, L. Massacesi, M. Vergelli, H. Kalbacher, F. Lolli and A.M. Papini. Influence of different N-linked glycosyl moiety at position 31 of hMOG(30-50) on anti-MOG antibody recognition in multiple sclerosis patients. 16th American Peptide Symposium, Minneapolis (Minnesota, USA), June 26-July 1, 1999, Abstract P148. Bruce W. Erickson Award. Third Place for outstanding achievement in peptide sciences, July 1, 1999, Minneapolis (Minnesota, USA).

2000 [P34] E. Peroni, G. Caminati, P. Baglioni, M. Chelli and A.M. Papini. Caratterizzazione fotofisica dell’interazione di lipopeptidi con modelli di membrana. XX Congresso nazionale della Società Chimica Italiana, Rimini (Italia), June, 4-9, 2000, Abstract NS-PO006. [P35] E. Nardi, M. Chelli, M. Ginanneschi, S. Meini, L. Quartara, M.R. Altamura, C.A. Maggi, F. Formaggio, C. Toniolo, Q.B. Broxterman, P. Rovero, and A.M. Papini. Lipophilic modifications of bradykinin agonists. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, J. Pept. Sci., Supplement to Vol. 6, 2000, S 216, Abstract P457.

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[P36] J. Uziel, M.C. Alcaro, G. Sabatino, A. Di Fenza, M. Ginanneschi, M. Chelli, P. Rovero and A.M. Papini. A Synthetic Strategy Toward Constrained Head-to-Tail Cyclopeptides Libraries by Amino Acid Side Chain Anchoring to Trityl Resins. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, J. Pept. Sci., Supplement to Vol. 6, 2000, S 103, Abstract P058. [P37] E. Nardi, E. Mastrangelo, S. Matà, B. Mazzanti, V. Zipoli, M. Chelli, M. Ginanneschi, L. Massacesi, M. Vergelli, F. Lolli, F. Pinto and A.M. Papini. Role of the Glycosyl Moiety in Autoantibody Recognition in Multiple Sclerosis. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, J. Pept. Sci., Supplement to Vol. 6, 2000, S 208, Abstract P433. [P38] A.M. D’Ursi, A. Carotenuto, E. Nardi, E. Mastrangelo, A.M. Papini and P. Rovero. Conformational Studies on glycopeptide fragments of human myelin oligodendrocyte glycoprotein. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, J. Pept. Sci., Supplement to Vol. 6, 2000, S 138, Abstract P166. [P39] E.. Peroni, G. Caminati, P. Baglioni, M. Chelli and A.M. Papini. A New Fluorescent Probe to Mimic Lipophilic Moieties for Interaction Studies of Bioactive Lipopeptides with Membrane Models. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, J. Pept. Sci., Supplement to Vol. 6, 2000, S 227, Abstract P494. [P40] M.C. Alcaro, A.M. Papini, M. Chelli, D.Fishlock, C. Atkins and G.A. Lajoie. Stereoselective Syntheses of β,γ-Unsaturated amino acids. 26th European Peptide Symposium, Montpellier (France), September 11-15, 2000, J. Pept. Sci., Supplement to Vol. 6, 2000, S 119, Abstract P101. [P41] A.M. D’Ursi, A. Carotenuto, E. Nardi, E. Mastrangelo, A.M. Papini, F. Lolli, F. Pinto, P. Rovero. Conformational Studies on a new synthetic MOG glycopeptide antigen able to block demyelinating antibodies in multiple sclerosis. 26th International Symposium of Medicinal Chemistry, Bologna (Italy), September 18-22, 2000.

2001 [P42] A.M. Papini, M.C. Alcaro, M. Chelli, and M. Ginanneschi. Cyclic pentapeptide metal ion complexation: a model of the binding unit of the Prion protein. EUROCOMBI-1, Budapest (Hongrie), 1-5 Juillet, 2001. [P43] M.C. Alcaro, M. Chelli, and A.M. Papini. Parallel solid phase synthesis of lipophilicγ,δ-unsaturated amino acids. EUROCOMBI-1, Budapest (Hongrie), 1-5 Juillet, 2001. [P44] A.M. Papini, E. Nardi, B. Mazzanti, T. Biagioli, E. Traggiai, C. Ballerini, M. Chelli, H. Kalbacher, L. Massacesi, and M. Vergelli. Different effect of lipoconjugation of MBP peptides for CD4+ T cell response. 11th International Congress for Immunology, Stockholm (Suède), 22-27 Juillet, 2001.

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[P45] A.M. Papini, S. Matà, E. Nardi, B. Mulinacci, M. Chelli, A. Carotenuto, P. Rovero, F. Pinto, L. Massacesi, M. Vergelli, and F. Lolli. Specific role of Asn(Glc) in autoantibody recognition to glycosylated peptides in Multiple Sclerosis. 11th International Congress for Immunology, Stockholm (Suède), 22-27 Juillet, 2001.

2002 [P46] M. Ginanneschi, S. Mazzucco, A. Carotenuto, P. Rovero, A.M. Papini, M. Chelli, and G. Sabatino. Synthesis of a new octreotide analogue for studies in clinical oncology. Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici, “From Genes to Molecules”, Certosa di Pontignano, Siene (Italie), 8-10 Fevrier, 2002, Book of Abstracts, PC36, p. 68. [P47] M.C. Alcaro, T. Terzani, F. Nuti, M. Chelli, M. Ginanneschi, F. Machetti, A. Brandi, L. Quartara, C.A. Maggi, and A.M. Papini. Study of the role of basic residues in peptide bradykinin antagonists. 23rd IUPAC 2002, International Symposium on the Chemistry of Natural Products, 28 Juillet-2 Août, 2002, Florence (Italie), Abstract Book, P7, p. 133. [P48] G. Sabatino, M. Chinol, G. Paganelli, M. Chelli, G. Leone, D. Fanucci, A.M. Papini, M. C. Alcaro, and M. Ginanneschi. Synthesis and in vitro stability of a new Vitamin H derivative conjugated to DOTA and carrying radioactive metals. 23rd IUPAC 2002, International Symposium on the Chemistry of Natural Products, 28 Juillet-2 Août, 2002, Florence (Italie), Abstract Book, P88, p. 214. [P49] F. Machetti, F. Cordero, F. De Sarlo, A.M. Papini, and A. Brandi. Studies toward Synthesis of enantiopure 4-substituited pipecolic acids. 23rd IUPAC 2002, International Symposium on the Chemistry of Natural Products, 28 Juillet-2 Août, 2002, Florence (Italie), Abstract Book, P136, p. 265. [P50] M. C. Alcaro, G. Sabatino, M. Ginanneschi, M. Chelli, A. Di Fenza, P. Rovero, and A.M. Papini. A synthetic strategy toward constrained head-to-tail cyclopeptides. 27th European Peptide Symposium, Sorrento (Italie), 31 Août- 6 Septembre, 2002, J. Pept. Sci., 2002, 8(Suppl.), S78, Abstract P A1. [P51] F. Nuti, F.M. Cordero, E. Peroni, M. Chelli, A.M. Papini, and A. Brandi. Synthesis of new Fmoc-protected iminosugars to study the role of the glycosyl moiety in autoantibody recognition in autoimmune diseases. 27th European Peptide Symposium, Sorrento (Italie), 31 Août- 6 Septembre, 2002, J. Pept. Sci., 2002, 8(Suppl.), S103, Abstract P A103. [P52] G. Sabatino, B. Mulinacci, M. C. Alcaro, M. Ginanneschi, M. Chelli, P. Rovero, and A.M. Papini. A comparative study of coupling reagents for automatic multiple peptide synthesizers. 27th European Peptide Symposium, Sorrento (Italie), 31 Août- 6 Septembre, 2002, J. Pept. Sci., 2002, 8(Suppl.), S91, Abstract P A56.

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[P53] E. Peroni, F. Lolli, B. Mulinacci, F. Nuti, B. Mazzanti, S. Matà, M. Chelli, F. Pinto, P. Rovero, and A.M. Papini. Innovative biocompatible immunoadsorbents containing immobilized selective glycopeptide antigens for Multiple Sclerosis therapy. 27th European Peptide Symposium, Sorrento (Italie), 31 Août- 6 Septembre, 2002, J. Pept. Sci., 2002, 8(Suppl.), S152, Abstract P C27. [P54] M. C. Alcaro, B. Anichini, T. Terzani, F. Nuti, M. Chelli, F. Machetti, L. Quartara, C. A. Maggi, A. Brandi, and A.M. Papini. New constrained amino acids for the study of the role of the basic residues in bradykinin antagonists. 27th European Peptide Symposium, Sorrento (Italie), 31 Août- 6 Septembre, 2002, J. Pept. Sci., 2002, 8(Suppl.), S95, Abstract P A72. [P55] B. Mulinacci, E. Peroni, G. Sabatino, S. Matà, M. Chelli, A. Carotenuto, P. Rovero, F. Pinto, F. Lolli, and A.M. Papini. Toward rationally designed glycopeptide antigens recognizing autoantibodies in Multiple Sclerosis patients. 27th European Peptide Symposium, Sorrento (Italie), 31 Août- 6 Septembre, 2002, J. Pept. Sci., 2002, 8(Suppl.), S141, Abstract P B47. [P56] B. Mulinacci, E. Peroni, G. Sabatino, M. Chelli, A. Carotenuto, P. Rovero, S. Matà, B. Mazzanti, F. Lolli, and A.M. Papini. Progettazione razionale di glicopeptidi da utilizzare in test Elisa per il monitoraggio della sclerosi multipla. XXVIII Convegno Nazionale della Divisione di Chimica Organica, Rome (Italie), 16-20 Septembre, 2002, Abstract P31. [P57] M. C. Alcaro, G. Sabatino, M. Ginanneschi, M. Chelli, P. Rovero, and A.M. Papini. Strategia di sintesi in fase solida di librerie di dichetopiperazine e di ciclopeptidi RGD. XXVIII Convegno Nazionale della Divisione di Chimica Organica della S.C.I., Rome (Italie), 16-20 Septembre, 2002, Abstract P42. [P58] E. Peroni, G. Caminati, P. Baglioni, F. Nuti, M. Chelli, and A.M. Papini. Sintesi di un nuovo probe fluorescente per lo studio di lipopeptidi come vaccini sintetici per la sclerosi multipla. XXVIII Convegno Nazionale della Divisione di Chimica Organica della S.C.I., Rome (Italie), 16-20 Septembre, 2002, Abstract P67. [P59] F. Nuti, S. Hildebrand, M. Chelli, A. Brandi, and A.M. Papini. Sintesi di metaboliti del di-2-etilesilftalato per la valutazione dei rischi tumorali da ftalati nell’uomo. XXVIII Convegno Nazionale della Divisione di Chimica Organica della S.C.I., Rome (Italie) , 16-20 Septembre, 2002, Abstract P87. [P60] G. Sabatino, B. Mulinacci, M. C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini. Studio comparativo di reagenti di accoppiamento per sintetizzatore automatico multiplo. XXVIII Convegno Nazionale della Divisione di Chimica Organica della S.C.I., Rome (Italie), 16-20 Septembre, 2002, Abstract P108.

2003

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[P61] M.C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini. Strategy to constrained cyclopeptide libraries. QSAR & Combinatorial Science. Vol. 22 n.4. Juin, 2003, P1, p. 47. [P62] A. Innocenti, M.C. Alcaro, M. Chelli, P. Rovero, and A.M. Papini. Synthesis and screening of a library of 4-sulfamoylphenylthioureas for the development of carbonic anhydrase inhibitors. QSAR & Combinatorial Science. Vol. 22 n.4. Juin, 2003, P22, p.52. [P63] V. Vinci, M.C. Alcaro, M. Chelli, S. Giuliani, S. Meini, M. Di Giacomo, L. Colombo, and A.M. Papini. Synthesis of bradykinin B2 antagonist containing dipeptide mimetics. XXI Congresso Nazionale della Società Chimica Italiana, Turin (Italie), 22-27 Juin, 2003, Atti Vol 2 SB-CP-001. [P64] B. Mulinacci, E. Peroni, G. Sabatino, M. Chelli, A. Carotenuto, P. Rovero, B. Mazzanti, M. Pazzagli, M.C. Pozo-Carrero, F. Lolli, and A.M. Papini. Structure-activity relationship study of glycopeptide antigens recognizing specific autoantibodies in Multiple Sclerosis. XXI Congresso Nazionale della Società Chimica Italiana, Turin (Italie), 22-27 Juin, 2003, Atti Vol 2, SB-CP-023. [P65] F. Nuti, I. Paolini, E. Peroni, M.C. Pozo-Carrero, B. Mazzanti, M. Pazzagli, F. Lolli, M. Chelli, F. Cordero, A. Brandi, and A.M. Papini. Sugar-scan of CSF114(Glc) for autoantibodies recognition in autoimmune disease. XXI Congresso Nazionale della Società Chimica Italiana, Turin (Italie), 22-27 Juin, 2003, Atti Vol 2, SB-CP-024. [P66] M.C. Alcaro, M. Orfei, A.M. Papini, M. Chelli, and M. Ginanneschi. A new solid-phase strategy leading to tetraazamacrocycles. XXI Congresso Nazionale della Società Chimica Italiana, Turin (Italie), 22-27 Juin, 2003, Atti Vol 2, SB-CP-025. [P67] E. Peroni, F. Lolli, B. Mulinacci, F. Nuti, M. Chelli, P. Rovero, and A.M. Papini. Innovative biocompatible immunoadsorbents containing immobilized selective glycopeptide antigens for Multiple Sclerosis therapy. XXI Congresso Nazionale della Società Chimica Italiana , Turin (Italie), 22-27 Juin, 2003, Atti Vol 2, SB-CP-028. [P68] G. Sabatino, M. C. Alcaro, M. C. Pozo-Carrero, M. Chelli, P. Rovero, and A.M. Papini. Assessment of 6Cl-HOBt-based coupling reagents in solid-phase cyclopeptide synthesis. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juin, 2003, P 004, Abstract p. 306. [P69] E. Peroni, F. Lolli, B. Mazzanti, M. Pazzagli, B. Bonetti, J. Hoebeke, L. Massacesi, M. Chelli, P. Rovero, and A.M. Papini. Towards a therapeutic apheresis in Multiple Sclerosis based on a glycopeptide antigen able to isolate specific autoantibodies. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juin, 2003, P 027, Abstract p. 311.

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[P70] B. Mulinacci, F. Nuti, G. Sabatino, M. Chelli, A. Carotenuto, P. Rovero, B. Mazzanti, M. Pazzagli, F. Lolli, and A.M. Papini. Structure-activity relationship study of glycopeptide antigens recognizing specific autoantibodies in Multiple Sclerosis. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juin, 2003, P 040, Abstract p. 314. [P71] F. Nuti, I. Paolini, B. Mulinacci, M.C. Pozo-Carrero, B. Mazzanti, M. Pazzagli, F. Lolli, M. Chelli, F. Cordero, A. Brandi, and A.M. Papini. Sugar–Scan of CSF114(Glc) for autoantibody recognition in autoimmune diseases. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juin, 2003, P 041, Abstract p. 314. [P72] A.M. Papini, B. Mulinacci, E. Peroni, F. Nuti, G. Sabatino, M.C. Pozo-Carrero, B. Mazzanti, M. Pazzagli, L. Massacesi, M. Chelli, P. Rovero, and F. Lolli. MS PepKit, the first diagnostic test based on CSF114(Glc) a glycopeptide to follow-up Multiple Sclerosis. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juin, 2003, P 454, Abstract p. 401. [P73] M. C. Alcaro, P. Campiglia, P. Grieco, E. Novellino, M. Chelli, and A.M. Papini. An efficient microwave-assisted synthesis of DKP libraries. 18th American Peptide Symposium, Boston, MA, USA, 19-23 Juin, 2003, P 553.