Signal Processing and Data Analysis2005-2008

21st July 2008

Members 20084 PhD, 3 PosDoc (2 - Ciência 2007), 2 PhD Stud

• 2005

– Ana Paula Rocha (PhD, FCUP) , PI

– Argentina Leite (PhD stud, FCUP and UTAD)

– Sónia Gouveia (PhD stud FCT, European PhD)

– Rute Almeida (PhD stud FCT, European PhD)

• 2006

– Ana Rita Gaio (PhD, FCUP)

– Rute Almeida (European PhD concluded)

• 2007– Helena Brás Silva (PhD, IPP)

– J. Pinto da Costa (PhD, FCUP)

– Rute Almeida (Pos Doc CiberBBN, Zaragoza)

• 2008 (May)

– Paulo Aguiar (Pos Doc Ciência 2007, CMUP)

– Murilo Baptista (Pos Doc Ciência 2007, CMUP)

• Biomedical Signals and Systems

Case Study: cardiovascular signals analysis

– Study of the ECG, multimodal cardiovascular variability and cardiorespiratory coupling

– Time, frequency, time/scale (wavelets), linear and non linear analysis

– Time variant modeling: Long-range / short term dependency in HRV (ARFIMA )

• Statistical Modeling in the Health Sciences

Case Study: nutritional and rheumatic epidemiology

– Classification techniques on continuous data: dietary patterns construction

– Latent variable models: knowledge of rheumatic disease versus health status

• Statistical Learning – Classification of ordinal data. Graph theory based clustering.

– Weighted measures in classification. Weighted PCA.

• Bioinformatics/Biomathematics – Computational Neuroscience

– Information/synchronization in active networks. Complex systems analysis.

• Scientific Consultancy (joint publications)

Research Lines

Collaborations

• Technical and Scientific– Italy: Mortara Rangoni / Portugal,CardioSolutions

– Spain: Univ Zaragoza, Communication technologies Group, Ciber BBN

– UK: Univ Edinburgh, Institute for Adaptive and Neural Computation

– USA/Brasil: Univ Illinois / Univ S. Paulo

– Germany: Univ. Potsdam and Max Plank Institute PKS

– Portugal: FEP, UP and UIMA, UA; INESC

• Clinical and Experimental– Belgium: Hospital Erasmus, Brussels

– Portugal: FMUP and Hospital S. João (HSJ) Porto

• SCIIP, Serviço de Cuidados Intensivos e Intermédios em Pediatria, HSJ

• Laboratório de Sono, Serviço Pneumologia HSJ, Porto

• Serviço de Higiene e Epidemiologia

• Instituto Histologia e Embriologia

– Portugal: FFUP (Serviço de Tecnologia Farmacêutica e Serviço de Toxicologia)

– Portugal: IBMC (Instituto de Biologia Molecular e Celular)

• Grupo de Neurobiologia Básica e Clínica

Achievements - Publications

• 2005-2006– 7 Papers in international peer reviewed Journals (ISI, IP Impact Factor 2006)

- Neuroscience IP=3.427

- IEEE Transactions on Biomedical Engineering IP=2.302

- Physiological Measurement IP=1.438

- Medical and Biological Engineering and Computing IP=1.018- Digital Signal Processing IP=0.889

- Biomedizinischie Technik IP=0.835

- Journal of Sensory Studies IP=0.794

– 6 Papers in Proceedings of International Conferences (5 ISI Proceedings)

• 2007-2008– 8 Papers in international peer reviewed Journals

- Journal of Machine Learning Research IP=2.255

- Neural Networks IP=2.000

- Ecotoxicology and Environmental Safety (in press) IP= 2.000

- Early Human Development (2; 1 in press, on line) IP=1.738

- Journal of Sensory Studies; IP=0.794

- Australian & New Zealand Journal of Statistics IP=0.347

- Cardiovascular & Haematological Disorders-Drug Targets

– 13 Papers in Proceedings of International Conferences

• 2005-2006

– PhD (3; 2 European Phd, 1 concluded)- Applied Mathematics (1 European Phd concluded 2006), AP Rocha

– MSc (3)- Computational Methods in Science and Engineering – 2005, AP Rocha

- Statistics – 2005, AP Rocha

- Mathematical Engineering - 2006, AR Gaio

• 2007-2008

– PhD (5, 2 concluded, 1 European Phd ongoing)- Computer Science – 2 - 1 concluded 2007, J Pinto da Costa

- Applied Mathematics - 2 - 1 waiting for Viva, 1 European Phd - AP Rocha

- Public Health - 1- AR Gaio

– MSc (7, 3 concluded)- Bioinformatics -1 – concluded 2007, AP Rocha

- Mathematical Engineering - 2 - concluded 2007, ARGaio / J.Pinto da Costa

- Statistics -1 , J.Pinto da Costa

- Mathematical Engineering -3, J.Pinto da Costa

- Medical Physics -1, AP Rocha

Graduate StudentsTraining

• 2005-2006Program: Scientific Research in Pre-Graduation. U Porto.

– Distinction Award, March 2005, project

Diabetes Mellitus: Early signs in the pré-sintomatic phase of the autonomic disfunctionFunding: Univ Porto / Fundação Ilídio Pinho. (1 student: FCUP)

– Cardiovascular variability analysis in critical illness: follow-up and outcome.

Funding: Univ Porto / Caixa Geral Depósitos (CGD). (9 students: 5 FCUP, 4 FMUP).

• 2007-2008Program: Scientific Research in Pre-Graduation. Pluridisciplinary Projects 2007.Funding: Univ Porto / CGD

- Multimodal analysis in pediatric coma (4 students: 3 FCUP, 1 FMUP).

- Arterial Blood Pressure responses and Heart Rate variability: role in the diagnosis and

prognosis of Sleep Disordered Breathing (2 students: FCUP).

• 2008-2009FCT Ciência 2008 BII (research integration of 5000 1st cicle students)

CMUP Call Posted EraCareers, July 2008

Pre-Graduate StudentsTraining

• 2005-2006

– Tachografic, Spectral and Fractal analysis of heart rate variability in pre and pos natal life. Application in medical diagnostics and educational systems.

Ref: POSI/CPS/40153/2001 (2002 – 2006). Funding: 55 000 € ( 21 628 € at FCUP ).

Involved Institutions: FEUP/INEB (Coordination), FCUP, FMUP. CMUP Team: AP Rocha.

– Tratamiento de señal en el análisis del ECG y polisomnografía: Procesado orientado por el modelado fisiológico.

Ref: CYCT/FEDER TEC2004-05263-C02-02, (Spain, 2004- 2007) . Funding: 123 200 €.

Involved Institutions: Zaragoza Uiversity (Spain, Coordination), FCUP (Portugal), Univ. Zaragoza, Hospital Miguel Servet, Zaragoza (Spain), Lund University (Sweden), Favaloro University (Argentina), Saint George Hospital, London (UK), Nice University (France).

CMUP Team: AP Rocha, RB Almeida

• 2007-2010

- Analisis multimodal-multicanal e interpretacion fisiológico diagnostica de señales

biomedicas del sistema cardiovascular, respiratorio autonomico y del sueño:

variabilidad dynamica e interacciones

Ref: CYCT/FEDER - TEC2007-68076-C02-02(Spain, 2007- 2010). Funding 215 351 €.

Extension of TEC2004-05263-C02-02. Innovation and links to foreign centers as Duke University Medical Center (USA), MIT (USA), Medtronics research center (Holland).

CMUP Team: AP Rocha, S Gouveia, RB Almeida (Ciber BBN)

Networking/Research Projects

• Biomedical Signals and Systems

Cardiovascular signals analysis and risk stratification

– Improved Multilead Wavelet ECG delineation and Cardiorespiratory coupling characterization.

– Correntropy as complementary to time, frequency, time/scale, linear and non linear analysis.

– Novel approaches in long-term and non stationary HRV modeling: volatility (ARFIMA-GARCH)

• Statistical Modeling in the Health Sciences

Case Studies from epidemiology and public health

– Classification techniques on ordinal data: dietary patterns construction

– Latent mixture variable models: detection of cardiac failure

• Statistical Learning– Classification of ordinal data. Graph theory based clustering.

– Weighted measures in classification. Weighted PCA.

• Bioinformatics/Biomathematics– Computational Neuroscience: neural connectivity/network architecture, activity level control in

spiking networks, learning and memory models…

– Information/synchronization in active networks. Complex systems analysis versus dynamic systems tools

• Ciência2008 – Joint Call 2 Pos Doc Positions - Statistical Analysis and Applications

Research 2007-2010

Case Study

Biomedical Signals and Systems

Cardiovascular signals analysis and risk stratification

Characterization in Ambulatory

and Long term

Follow-up and prognosis in

Critical Care Bedside

ECG automatic delineation

using Wavelet methodologies

RR analysis / Heart Rate Variability ECG Variabilities interactions

QT variability driven by RR

Beat-to-beat variability series

24 hours

Multimodal analysis for the characterization of the cardiovascular system

Sleep as a cardiovascular frontier

Sleep apnea studies

Goal: Understanding of the ANS

Invasive and drug induced experiments

• ECG and Arterial Blood Pressure

• Thorax respiratory effort sensors

• Nasal Flow Channels

• Oxygen saturation

• EEG, EOG, EMG, Body position sensors

• ECG and Arterial Blood Pressure

• Respiration

• Muscular Sympathetic Neural Activity

Polissonography study