College of PharmacyLS SKAGGS Institute

Department of Pharmaceutics & Pharmaceutical Chemistry

Sing Yian Chew, Ph.D.Associate Professor

College of EngineeringSchool of Chemical & Biomedical Engineering

Nanyang Technological University Singapore, China

"Scaffold-mediated Non-viral Delivery of Small Non-coding RNAs for Sustained Gene Silencing in Regenerative Medicine"

Nanofiber scaffolds closely imitate the size-scale and architecture of the natural extracellular matrix. These constructs represent a unique class of materials in regenerative medicine and non-viral drug/gene delivery. Fibrous topography can direct cell fate. Combined with the incorporation of gene silencing molecules, such as small non-coding RNAs, these scaffolds provide synergistic topographical and biochemical cues to seeded cells. Here, we will present our recent findings on the roles of nanofiber-mediated gene silencing on improving host-implant integration; directing neural stem/progenitor cell differentiation; and enhancing tissue regeneration and remyelination after traumatic nerve injuries.

Presents Speaker

Monday, October 2, 2017HSEB 4100B

4:00 - 5:00pm

Note: Regular Department Seminar. Attendance is mandatory for PHCEU graduate students. Attendance will be taken.