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Site of most chemical reactions in the cell
The Levels of organization
Anything that has Anything that has massmass and and takes up takes up spacespace (volume). (volume).
All matter is made up of All matter is made up of atoms.atoms.
ATOMSATOMS
The small units of matter The small units of matter
Made up of Protons, Neutrons, Made up of Protons, Neutrons, and Electrons and Electrons
Atoms are smaller than cells Atoms are smaller than cells
Pure substances made up of only one type of atom
-Major 4 elements:CarbonHydrogenOxygenNitrogen
(C)(H)(O)(N)
COMPOUNDSCOMPOUNDS
• combination of combination of 2 or more elements2 or more elements in in definite proportionsdefinite proportions– Ex: water, salt, glucose, carbon dioxide Ex: water, salt, glucose, carbon dioxide
Inorganic Compounds
Do not contain carbon(exceptions: CO and CO2)
Types:
WaterSaltsAcidsBases
usually
Organic Compounds
Always contain C and HUsually have O and NMay contain P and SAssociated with life:
bodies of organisms, remains, waste
Four Types of Organic CompoundsCarbohydratesLipidsProteinsNucleic Acids
The smallest part of a The smallest part of a compound that has the compound that has the properties of that compound. properties of that compound.
Example: HExample: H22OO
Atoms of the same element that bond inpairs to become stable.
H2
O2
N2
Never found innature as singleatoms.
FORMULAS FORMULAS • Chemical symbols and numbers that Chemical symbols and numbers that
make up a compound ("make up a compound ("reciperecipe")")
• Structural FormulaStructural Formula – Line drawings of the – Line drawings of the compound that shows the elements in compound that shows the elements in proportion and how they are bondedproportion and how they are bonded
• Molecular FormulaMolecular Formula – the ACTUAL – the ACTUAL formula for a compoundformula for a compound
CC66HH1212OO66
THE PROTON
p+
• Fat (heavy)
• Positive (charge)
• Doesn’t move (lazy)
THE NEUTRON
N°
• Fat (heavy)
• Neutral (charge)
• Doesn’t move (lazy)
THE ELECTRON• Skinny (very light)
• Negative (charge)
• Moves a lot (runs around)
e-
Review: Subatomic Particles
e-
N°
p+
The outermost electrons of an element.
Valence electrons are the most reactive and are involved in chemical bonding.
http://www.Chemicool Periodic Tablechemicool.com/
• Hold atoms in molecule togetherHold atoms in molecule together
• 3 types of chemical bonds:3 types of chemical bonds:– IONICIONIC
– COVALENTCOVALENT
– HYDROGENHYDROGEN
• 1 or more electrons are 1 or more electrons are TRANSFERREDTRANSFERRED from one atom to anotherfrom one atom to another
• If atom loses an electron: If atom loses an electron: POSITIVEPOSITIVE chargecharge
• If atom gains an electron: If atom gains an electron: NEGATIVENEGATIVE charge charge
• These newly charged atoms are now These newly charged atoms are now called called IONSIONS– Example: NaCl (SALT)Example: NaCl (SALT)
• Electrons are Electrons are SHAREDSHARED by atoms by atoms
• New structures that result are called New structures that result are called MOLECULESMOLECULES
SHARING IS CARING!SHARING IS CARING!
Which type of bond? Covalent or ionic?
Which type of bond? Covalent or Ionic?
Valence Electrons
bonding that involves electronegative attraction between H atoms
1) Universal solvent
2) Medium for chemical reactions
3) Raw material for chemical reactions
4) Transport medium
Penny ActivityPenny Activity• Obtain a penny and a pipette with HObtain a penny and a pipette with H22OO
• Your goal is to place as many drops of water on Your goal is to place as many drops of water on the surface of the penny without spilling the Hthe surface of the penny without spilling the H22O.O.
• Place drops on the penny one at a time and keep Place drops on the penny one at a time and keep track (be honest) of how many you place on the track (be honest) of how many you place on the penny.penny.
• Record your results in your notes.Record your results in your notes.
Penny ActivityPenny Activity• Why were you able to place so many drops Why were you able to place so many drops
of water on the penny?of water on the penny?
• What type of bond might be involved?What type of bond might be involved?
• What are adhesion and cohesion?What are adhesion and cohesion?
• Did the side of the penny affect your Did the side of the penny affect your results?results?
Contain C, H, O
Ratio of H and O is 2:1
Most end in “ose”
Building Block = MonosaccharideGlucoseFructoseGalactose
C6H12O6
C6H12O6
Same MolecularFormula
DifferentStructuralFormulas
Mono=one
Molecules formed by joining two monosaccharides
Glucose + Glucose Maltose
Glucose + Fructose Sucrose
Glucose + Galactose Lactose
C12H22O11
Di=two
Long chain of joined monosaccharides
(Sugar Polymer)
Organisms store excess glucose aspolysaccharides
Plants store as STARCH
Animals store as GLYCOGENExamples: cellulose, chitin
Poly=many
1) Quick energy source
2) Make cell structures (cell walls)
How are complex carbohydrates How are complex carbohydrates formed and broken down? formed and broken down?
H2OMaltose
(Disaccharide)Process that joins molecules by
removing water
H2O
Maltose
H HO
Glucose Glucose
Process that breaks down molecules byadding water.
Fats Oils Waxes
Contain C, H, O
Less O then found in Carbohydrate
Building Blocks =1 Glycerol
&3 Fatty Acids
1) Reserve energy source (9 calories/gram)
2) Component of cell structures(example: Cell Membrane)
3) Insulation and Cushioning
Lipids are found in the cell membrane of cells.
Contains C, H, O, N
Building Block = Amino Acids
Amino Acid consists of:1) Central C atom2) Carboxyl group3) Amino group4) H atom5) Representative group ®
Sometimes contains S and P
Amino Acid
R = H (Glycine)
R = CH3 (Alanine)
AN R GROUP IS ANY AN R GROUP IS ANY GROUP OF ATOMS – GROUP OF ATOMS – THIS CHANGES THE THIS CHANGES THE PROPERTIES OF THE PROPERTIES OF THE PROTEIN!PROTEIN!
What is the R group in this compound?
H2O
Peptide Bond
________
What is the name of this process?
Protein consisting of three or moreamino acids joined together
Polypeptide
1) Structural Parts (hair, nails, cartilage)
2) Pigments (blood, skin, eyes)
3) Contractile Material (muscle tissue)
4) Antibodies (protect against infection)
5) Hormones (Chemical messengers)
6) Enzymes (control chemical reactions)
7) Energy Source (4 calories/gram)
Contains C, H, O, N, P
Two Types:Deoxyribonucleic Acid (DNA)Ribonucleic Acid (RNA)
DNA – Hereditary Material RNA – Controls activities and development
of cells
Building Block = Nucleotide
Nucleotide consists of:
1) Five carbon sugar
2) Phosphate group
3) Nitrogen base
P
adeninethymineguaninecytosine
(DNA only)
uracil (RNA only)
AT
GC
U
AGGTCAATGCCG
TCCAGTTACGGC
DNA
GAUCCUACGUAC
CUAGGAUGCAUG
RNA
DNA RNA
Double Stranded Single Stranded
Deoxyribose Ribose
Thymine Uracil
P
P
P
P
P
PG C
A
T
C G
A
T
P
P
Base Pair RuleA TG C
ACIDS & BASESACIDS & BASES• Acids: Begin with "H-" (excess of H+ Acids: Begin with "H-" (excess of H+
ions: hydrogen)ions: hydrogen)– Ex: lemon juice (6), stomach acid (1.5), acid Ex: lemon juice (6), stomach acid (1.5), acid
rain (4.5), normal rain (6)rain (4.5), normal rain (6)
Facts about AcidsFacts about Acids
• Acids turn litmus paper Acids turn litmus paper REDRED and usually and usually taste taste SOURSOUR. .
• You eat acids daily (coffee, vinegar, You eat acids daily (coffee, vinegar, soda, spicy foods, etc…)soda, spicy foods, etc…)
ACIDS & BASESACIDS & BASES• Bases: end with -OH (excess of hydroxide Bases: end with -OH (excess of hydroxide
ions: Oxygen & Hydrogen)ions: Oxygen & Hydrogen)– EX: oven cleaner, bleach, ammonia, sea water, EX: oven cleaner, bleach, ammonia, sea water,
blood, pure waterblood, pure water
Facts about BasesFacts about Bases
• Bases turn litmus Bases turn litmus BLUEBLUE. .
• Bases usually feel Bases usually feel SLIPPERYSLIPPERY to touch and to touch and taste taste BITTERBITTER. .
Neutralization Reactions Neutralization Reactions
• When an acid reacts with a base to produce When an acid reacts with a base to produce a salt and water.a salt and water.
pH SCALEpH SCALE• measures degree of measures degree of
substance alkalinity or substance alkalinity or acidityacidity
• Ranges from Ranges from 0 to 140 to 14
• 0 – 5 strong acid0 – 5 strong acid
• 6-7 neutral6-7 neutral
• 8-14 strong base8-14 strong base
Effects of Acid Rain
• The goal of the body is to maintain The goal of the body is to maintain HOMEOSTASISHOMEOSTASIS – to do this when pH is – to do this when pH is concerned, we add weak acids & bases to concerned, we add weak acids & bases to prevent sharp changes in pH. prevent sharp changes in pH.
• These are called These are called BUFFERSBUFFERS
Homeostasis: relatively stable internal environment a.k.a: dynamic equilibrium
Protein substance …made on ribosomesControl all chemical reactions in organisms
Not changed by the reactionCan be used again
Referred to as an “organic catalyst”
Substrate: Substance enzymes works on
Lower activation energy (NRG needed to start Rx)
Dr. David R. Howard, Asst. Prof. Univ. of Wisconsin La Crosse
Usually ends in “ase”
Name often comes from substrate
Examples:
Maltase (Maltose Glucose)
Protease (Breaks down proteins)
Lipase (Breaks down lipids)
Temporary union of the enzyme andsubstrate at the “active site”
Active Site:
- Area of an enzyme - Substrate molecule fits in shape of active site- Active sites are specific for substrates
Figure 8.16
Substate
Active site
Enzyme
(a)
Figure 8.16 (b)
Enzyme- substratecomplex
Enzymes work on specific substratesReason: specific active site on enzyme
Example: Lactase only breaks down LactoseMaltase only breaks down MaltoseCellulase only breaks down cellulose
1) Small amounts of enzymes can cause the reaction of large amounts of substrates
2) Enzymes allow cell reactions to occur at “normal” temperatures
3) Enzymes work best at specific temperaturesOptimal Temperature is when enzymeis most effective
Denaturation: Deformation of active sitedue to high temperature
4) Enzymes work best at certain pH
Human Examples:Amylase pH 8Pepsin pH 2Trypsin pH 8
5) Rate of an enzyme controlled reaction depends on the concentration of enzymes and substrates.
- more enzymes faster the rate of reaction- maximum rate (enzymes = substrates)
** When there is a fixed amount of enzyme ** When there is a fixed amount of enzyme and an excess of substrate molecules -- the and an excess of substrate molecules -- the rate of reaction will increase to a point and rate of reaction will increase to a point and then level off**then level off**
6) Some enzymes need coenzymes to function
Coenzymes:- are not proteins
- may be part of enzyme molecule or a separate molecule
- may be altered during E-S Complex, but return to original form after reaction
- may be vitamin or made from vitamin
7) Most enzymes functions inside cells, some functions outside
- all enzymes are made by cells
- digestive enzymes function outside cells
Enzymes(and beyond …)
• Inhibitors—reduce the productivity of enzymes as seen to the right with herbicides.
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