consensus measures for Phenotypes and eXposures

https://www.phenxtoolkit.org

PhenX Measures for Tobacco Regulatory ResearchDr. Kay Wanke is the NIH Office of Disease Prevention Project Scientist of the PhenX Measures for Tobacco Regulatory Research (TRR) Project.

Co-Chairs of the TRR Panel are Dr. Gary Swan and Dr. Judith Prochaska, both of Stanford University.

Collection Name Measure Name

TRR Core Tier 1

Recommended for use by all tobacco regulatory researchers; relevant and essential to all areas of TRR and require very little time to collect

1. Current Age 2. Ethnicity 3. Race 4. Gender 5. Current Marital Status

6. Current Educational Attainment 7. Current Employment Status 8. Use of Tobacco Products 9. Tobacco - Nicotine Dependence 10. Electronic Nicotine Product Device Type

TRR Core Tier 2

Recommended for use by all tobacco regulatory researchers; also relevant to many areas of TRR but are more specialized and require a greater time commitment

1. Annual Family Income 2. Child-reported Parental Education

Attainment 3. Self-Reported General Health Status 4. Veteran Status 5. Peer and Family Influence on Smoking 6. Flavor Preference - e-Cigarettes 7. Tobacco Brand and Variety 8. Self-reported Tobacco Product Price Paid

9. Exposure to Tobacco Advertising on the Internet and Social Media

10. Internalizing, Externalizing, and Substance Use Disorders Screener

11. Self-reported Craving 12. Smoking Quit Attempts 13. Passive Smoke Exposure 14. Cotinine - Coming Soon!15. Blunt Use

Host: Social/Cognitive Working Group Co-Chairs:

Dr. Thomas H. Brandon, Moffitt Cancer Center, and Dr. Stephen Tiffany, University at Buffalo, State University of New York

1. Behavior Economics/Purchase Behavior2. Quality of Communication about Smoking3. Attention4. Peer and Family Influence on Smoking5. Hedonic Tone or Response to Pleasurable

Situations

6. Susceptibility to Smoking Cigarettes7. Multigroup Ethnic Identity 8. Frequency of Communication about Smoking9. Motivation to Quit10. Distress Tolerance11. House Rules about Tobacco Use

Host: Biobehavioral Working Group Co-Chairs:

Dr. Anne Joseph, University of Minnesota, and Dr. Stephanie O’Malley, Yale University

1. Withdrawal from Tobacco Use2. Flavor Preference - e-cigarettes3. Pregnancy Status - Mother and Baby Health4. Cotinine in Serum5. Pregnancy Status and Tobacco Use

6. Cue Reactions to Tobacco Stimuli7. Expired Carbon Monoxide8. Amount, Type, and Frequency of Recent Cigarette Use9. NNAL in Urine

AgentWorking Group Co-Chairs:

Dr. Richard J. O’Connor, Roswell Park Cancer Institute, and Dr. Clifford Watson, Centers for Disease Control and Prevention

1. Tobacco Brand and Variety2. Passive Exposures to Tobacco Products3. Nicotine Content4. Tobacco Warning Label Exposure and Recall

5. History of Switching to Lower Tar and Nicotine Cigarettes

6. Physical Properties of Tobacco Products7. Tobacco Product Adulteration - Vent or Filter Blocking

Vector Working Group Co-Chairs:

Dr. Frank Chaloupka, University of Illinois at Chicago, and Dr. Kurt Ribisl, University of North Carolina at Chapel Hill

1. Use of Tobacco Products2. Self-reported Tobacco Product Purchase

Location3. Self-reported Exposure to Tobacco Product

Sponsorships4. Illicit Tobacco Products5. Self-reported Tobacco Product Price Paid6. Tobacco Industry and Retailer Public Relations7. Self-reported Exposure to Tobacco Advertising

at Point of Sale

8. Exposure to Tobacco Marketing through Internet and Social Media Use

9. Self-reported Exposure to and Use of Price Promotions for Tobacco Products

10. Use of a Regular Brand of Tobacco11. Standardized Tobacco Assessment for Retail Settings12. Self-reported Exposure to Tobacco Product

Advertisements13. Tobacco Retailer Density/Proximity

Environment Working Group Co-Chairs:

Dr. Frank Chaloupka, University of Illinois at Chicago, and Dr. Donna Vallone, Truth Initiative

1. Self-reported Exposure to Smoking on Television and in the Movies

2. Media Use3. State Tobacco Control Public Policies4. Youth Cigarette Purchase Behaviors and

Experiences5. Local Tobacco Control Public Policies

6. Interpersonal Communication about Anti-tobacco Advertising

7. Aided Confirmed Awareness of Televised Anti-tobacco Advertisement

8. Worksite Policies9. Compliance with Cigarette Packaging and Labeling

Policies10. Social Norms about Tobacco

Related projects, links, and additional resources can be found at https://www.phenxtoolkit.org

Related Projects, Links, and Additional Resources can be found at https://www.phenxtoolkit.org09-2016

What is the PhenX Toolkit?The PhenX Toolkit is an online catalog of recommended, standard measures and is available for use at no cost at https://www.phenxtoolkit.org.

The purpose of the PhenX Toolkit is to:• Provide recommended, standard measures of phenotypes

and exposures for use in biomedical research• Facilitate acceptance and use of standard PhenX measures• Promote collaboration and facilitate cross-study analyses

Researchers visit the Toolkit to:• Select and incorporate standard measures into

ongoing studies• Consider PhenX measures when planning new studies• Review and select high-quality, recommended, standard

measures in order to expand a study beyond the primary research focus

• Review and select PhenX measures that relate to researchers’ primary research focus

PhenX Toolkit features:• The Smart Query Tool provides two search options: a Smart

Search based on keywords (and synonyms) and a Text Search that searches all text

• Browse options: Domains, Measures, Collections, Supplemental Information, and hierarchical tree view

• Link your study to find other researchers using the same measures and to explore opportunities for cross-study analysis

• Standards included: cancer Data Standards Registry and Repository (caDSR) Common Data Elements (CDEs); Logical Observation Identifiers Names and Codes (LOINC)

• Registered Users have access to additional features and functionality (e.g., saving more than one “My Toolkit”)

• Quick Start and Tutorial resources help new users become familiar with the Toolkit

• Annotation Tool in Toolkit Resources: Annotate the PhenX protocols that you use to assess sickle cell disease and other conditions

• REDCap Instrument Zip files for PhenX protocols can be uploaded directly to REDCap

• Variable and dbGaP variable mapping results

For each PhenX measure, the following information is provided:• Brief description of the measure• Rationale for selecting

the measure for inclusion in the Toolkit

• Detailed protocol(s) for collecting the measure• Information about the personnel, training, and equipment

needed to collect the measure• Any special requirements• Essential and Related measures• References

PhenX Research Domains

• Alcohol, Tobacco and Other Substances

• Anthropometrics

• Cancer

• Cardiovascular

• Demographics

• Diabetes

• Environmental Exposures

• Gastrointestinal

• Infectious Diseases and Immunity

• Neurology

• Nutrition and Dietary Supplements

• Obesity

• Ocular

• Oral Health

• Physical Activity and Physical Fitness

• Psychiatric

• Psychosocial

• Rare Genetic Conditions

• Reproductive Health

• Respiratory

• Skin, Bone, Muscle and Joint

• Social Environments1

• Speech and Hearing

1 Funding for the Social Environments domain provided by the Office of Behavioral and Social Sciences Research (OBSSR).

PhenX supplements:Several National Institutes of Health (NIH) institutes and programs have contributed supplemental funding to add depth to the Toolkit in specific areas of research.

PhenX Measures for Sickle Cell Disease Research

funded by the National Heart, Lung, and Blood

Institute (NHLBI).

PhenX Measures for Tobacco Regulatory Research

were supported by NIH and the Food and Drug

Administration’s Center for Tobacco Products (CTP).

Mental HealthResearch

PhenX Measures for Mental Health Research funded by

the National Institute of Mental Health (NIMH).

PhenX Measures for Substance Abuse and Addiction

Research funded by the National Institute on Drug

Abuse (NIDA).

The PhenX Toolkit Genomic Resource Grant (U41) is funded by the National Human Genome Research Institute (NHGRI) with co-funding from NIDA, both of NIH.

Dr. Carol M. Hamilton is the RTI International Principal Investigator, and Dr. Erin M. Ramos is the NHGRI Project Scientist.

More information is available at the project web portal: https://www.phenx.org