S c i e n c e · E d u c a t i o n · P e o p l e · P r o g r e s s

62nd AAN Annual Meet ingA p r i l 1 0 — A p r i l 1 7, 2 0 1 0

Early Registration Deadline: March 10, 2010

Scientific Abstract Listing and Annual Meeting Information

70 71

Poster Session IVWednesday, April 14 | 3:00 p.m.–7:30 p.m. First Authors Stand by Poster from 6:00 p.m.–7:30 p.m.Poster Session IV Wednesday, April 14 | 3:00 p.m.–7:30 p.m.

Metro Toronto Convention Centre / Room 808

Poster Discussion Session: Movement Disorders: Parkinson's Disease: Treatment Location: 800 LevelModerators: TBD

PD4.001 A Randomized, Double-Blind, Placebo-Controlled Cross-Over Trial of the Adenosine 2a Antagonist SYN115 in Parkinson Disease Kevin Black, Meghan Campbell, Wesley Dickerson, Mary Creech, Jonathan Koller, St. Clare Chung, Stephen Bandak

PD4.002 The Natural Progression of Clinical Symptoms in Parkinson’s Disease May Not Be Faster in the Earlier Stages: Results from the ADAGIO Delayed-Start Study Olivier Rascol

PD4.003 Overnight Conversion From Immediate-Release to Extended-Release Pramipexole for Adjunctive Treatment of Advanced Parkinson’s Disease Anthony Schapira, Paolo Barone, Robert Hauser, Youshikuni Mizuno, Werner Poewe, Olivier Rascol, Michael Busse, Laurence Salin, Mandy Sohr, in the Name of the Pramipexole ER Studies Group

PD4.004 Efficacy of the Adenosine A2A Receptor Antagonist BIIB014 in Parkinson’s Disease (PD) Patients with Motor Fluctuations Spyridon (Spyros) Papapetropoulos, Rupam Borgohain, Mark Kellett, Nir Giladi, Davorka Tomic, Alex Coppell, John Barnard, Ying Zhu, Gilmore O’Neill

PD4.005 Safety and Tolerability Profile of the Adenosine A2A Receptor Antagonist BIIB014 as an Adjunct Treatment in Parkinson’s Disease (PD) Patients with Motor Fluctuations Spyridon (Spyros) Papapetropoulos, Rupam Borgohain, Mark Kellett, Nir Giladi, Davorka Tomic, Alex Coppell, John Barnard, Ying Zhu, Gilmore O’Neill

PD4.006 Initial Diagnosis and Treatment Patterns in Parkinson’s Disease Maureen Lage, Marcy Tarrants, Jane Castelli-Haley

PD4.007 Long-Term Study on Clinical Benefits and Quality of Life of Intraduodenal Levodopa in Routine Care for a Cohort of Treatment-Naïve Patients with Advanced Parkinson’s Disease S. Pälhagen, N. Dizdar, T. Hauge, B. Holmberg, R. Jansson, J. Linder, H. Widner, A. Johansson

PD4.008 Synthesis and Evaluation of Novel Compounds for the Treatment of Parkinson’s Disease Niran Argintaru, Dipannita Basu, Bailee Dyck, Ram Mishra, Rodney Johnson

PD4.009 Controlled Study of Intermittent Theta-Burst Transcranial Magnetic Stimulation for the Treatment of Parkinson’s Disease David Benninger, Brian Berman, Elise Houdayer, Natassja Pal, Dave Luckenbaugh, Logan Schneider, Sabina Miranda, Mark Hallett

PD4.010 Effect of Safinamide on Levodopa-Induced Dyskinesia in Patients with Parkinson’s Disease Mohit Bhatt, Dana Chirileanu, Chandrashekhar Meshram, Paolo Stanzione, Emma Forrest, Valentina Lucini, on Behalf of the Study 016 Investigators

Behavioral Neurology: MemoryP04.030 Double Dissociation of Semantic and Episodic Memory Impairment in Temporal Variant Frontotemporal Dementia and Alzheimer’s Disease Kimiko Domoto-Reilly, Lucille Pellerin, Alyson Negreira, Michael Brickhouse, Daisy Sapolsky, Bradford Dickerson

P04.031 False Recognition of Unfamiliar Faces in Frontotemporal Dementia Steven Rapcsak, Emily Edmonds, Maya Henry, G. Hishaw, Bryan Woodruff

P04.032 Loss of Future Oriented Behavior in a Patient with Behavioral Variant Frontotemporal Dementia Jee Hoon Roh, Mee kyung Seo, Ji Hye Yoon, Duk L. Na

P04.033 MRI Features Mimicking Limbic Encephalitis and CJD in Hashimoto’s Encephalopathy Without Paraneoplastic Antibodies Asa Cordle, Matthew Ostrander, Daniel Kaufer

P04.034 Profiles of Performance in Verbal Serial List Learning in Alzheimer’s Disease and Semantic Dementia Ashley Boller, Brianna Morgan, David Libon, Murray Grossman

P04.035 Patterns of Memory Deficit Modify the Rate of Conversion to Dementia in a Large Sample of Patients with Mild Cognitive Impairment Pablo Martinez-Lage, Isabel Hernandez, Merce Boada Rovira, Montserrat Alegret, Ana Espinosa, Georgina Vinyes, Ana Mauleon, Asuncion Lafuente, Maitee Rosende, Susana Ruiz, James Becker, Lluis Tarraga

P04.036 Graphabulation, a New Form of Confabulation J. Hoon Roh, Duk L. Na

P04.037 Vitamin D, Fall Frequency, and Cognitive Function in Free-Living Elders Amie Peterson, Nora Mattek, Aaron Clemons, Gene Bowman, Teresa Buracchio, Jeffrey Kaye, Joseph Quinn

P04.038 Prospective Evaluation of 32 Patients with Symptoms of Transient Global Amnesia (TGA) in a Community Hospital of Argentina Maria Fernandez, Juan Rojas, Angel Golimstok, Edgardo Cristiano

P04.039 Hyposmia, Central Cholinergic Integrity, and Cognitive Impairment in Parkinson Disease Without Dementia Nicolaas Bohnen, Martijn Muller, Vikas Kotagal, Robert Koeppe, Michael Kilbourn, Roger Albin, Kirk Frey

P04.040 Dissociation Between Two Routes to Action in Gesture Imitation Eric Roy, Timour Al-Khindi, Mark Gravely, Loch MacDonald, Sandra Black, Tom Schweizer

Behavioral Neurology: Executive and Motor FunctionsP04.041 Gait Disorders, an Interesting Marker of Frontotemporal Dementia Gilles Allali, Bruno Dubois, Frederic Assal, Elise Lallart, Leonardo de Souza, Maxime Bertoux, Cedric Annweiler, Francois Herrmann, Richard Levy, Olivier Beauchet

P04.042 Validation of a Simple Bedside Antisaccade Task in Neurodegenerative Dementia Joanna Hellmuth, Alisa Matlin, Mary Widmeyer, Ashley Berhel, Aria Jafari, Joel Kramer, Bruce Miller, Adam Boxer

P04.043 Reckless Driving Associated with Dopamine Agonist Use: A Case Series Alida Griffith, Pinky Agarwal, Marilyn Borromeo-Westner

P04.044 Right Inferior Frontal Gyrus Is Necessary for Interference Suppression, but Not Error Correction, in the Eriksen Flanker Task Maiya Geddes, Ami Tsuchida, Mandana Modirrousta, Adam Aron, Lesley Fellows

P04.045 Executive Functions and Cognition in Amyotrophic Lateral Sclerosis Natalia Sierra, Alberto Dubrovsky, Ana Gamba, Teresa Torralva, María Roca, Facundo Manes

P04.046 Insight of Involuntary Movements in Early Huntington’s Disease: A Simple Explanation Damian Justo, Perrine Charles, Valerie Hahn-Barma, Lionel Naccache, Sophie Tezenas Du Montcel, Celine Jauffret, Cecilia Marelli, Marcela Gargiulo, Alexandra Durr

P04.047 Relationship Between Cognition and Spatiotemporal Gait Parameters in Parkinson Disease without Dementia Nicolaas Bohnen, Martijn Muller, Kirk Frey, Roger Albin

P04.048 Quantification of Increased Mirror Overflow in ADHD: Laterality and Gender Effects Stewart Mostofsky, Priya Xavier, Lindsey MacNeil, Kelly Isaacs, Amanda Lewis, Martha Denckla, Donald Gilbert

P04.049 Excessive Hoarding in Parkinson’s Disease Sean O’Sullivan, Atbin Djamshidian, Andrew Evans, Clare Loane, Andrew Lees, Andrew Lawrence

P04.050 Neuropsychological Profile of Adult Patients with Duchenne Muscular Dystrophy Natalia Sierra, Lilia Mesa, Alberto Dubrovsky, Pablo Sojo, Teresa Torralva, María Roca, Fernando Chloaca, Laura Pirra, Facundo Manes

Anterior Horn: Spinal Muscular AtrophyP04.051 Trends in Outcomes and Hospitalization Costs among Patients with Warding’s Hoffman Disease in the United States Khan Hafiz, Lubna Mehyar, Bilal Saulat, Shahanara Islam, Nizar Souayah

P04.052 The Role of Ulnar Compound Muscle Action Potential (U-CMAP) as a Surrogate Outcome Measure in Ambulatory Adults with Spinal Muscular Atrophy (AA-SMA) Bakri Elsheikh, Kathryn Swoboda, Charles Scott, Wendy King, Elizabeth Bollman, Kristin Krosschell, Bernard LaSalle, Stephen Kolb, John Kissel

P04.053 Beta-Lactam Antibiotics Offer Neuroprotection in a Spinal Muscular Atrophy Mouse Model by Multiple Mechanisms Monica Nizzardo, Martina Nardini, Dario Ronchi, Sabrina Salani, Chiara Simone, Marianna Falcone, Chiara Donadoni, Nicoletta Mezzina, Francesca Gianni, Nereo Bresolin, Giacomo Comi, Stefania Corti

P04.054 Salbutamol Increases SMN mRNA in Spinal Muscular Atrophy Patients (SMA): Relevance for Clinical Trial Design Francesco Tiziano, Rosa Lomastro, Anna Pinto, Sonia Messina, Adele D’Amico, Stefania Fiori, Carla Angelozzi, Marika Pane, Eugenio Mercuri, Enrico Bertini, Giovanni Neri, Christina Brahe

P04.055 Further Progress in Defining UBE-1 Mutations and Downstream Effects Underlying X-Linked Lethal Infantile SMA (XL-SMA) Lisa Baumbach, Mary Ellen Ahearn, Juliane Ramser, Kemal Yariz, Thomas Prior, Zafar Nawaz, Antonio Barrientos, Alfons Meindl

P04.056 Hand Held Dynamometry and Fixed Maximal Voluntary Isometric Contraction Strength Testing in Ambulatory Adults with Spinal Muscular Atrophy Wendy King, Bakri Elsheikh, Chuck Scott, Bernard LaSalle, Kristin Krochell, John Kissel

P04.057 Biomarker Study for Spinal Muscular Atrophy: Study Design and Preliminary Results Richard Finkel, Thomas Crawford, Kathryn Swoboda, Petra Kaufmann, Margaret Bell, Rebecca Li, Felicia Trachtenberg, Thomas Plasterer, Peter Juhasz, Xiaohong Li, Karen Chen, Rory Olson, Jenny Shu, Sergey Paushkin, Dione Kobayashi, Cynthia Joyce, Suzanne Forrest

P04.058 Videofluorography in Spinal and Bulbar Muscular Atrophy (SBMA) Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki, Seiya Tanaka, Motoshi Kawashima, Noriaki Suga, Atsushi Hashizume, Yasushi Fujimoto, Gen Sobue

P04.059 Reliability of the Six-Minute Walk Test in Ambulatory Patients with Spinal Muscular Atrophy W. Arnold, Bakri Elsheikh, Kathryn Swoboda, Charles Scott, Wendy King, Elizabeth Bollman, Bernard LaSalle, Kristin Krosschell, John Kissel

P04.060 Fatigue Related Spatiotemporal Gait Changes During the Six-Minute Walk Test in Spinal Muscular Atrophy (SMA) Jacqueline Montes, Sally Dunaway, Megan Montgomery, Douglas Sproule, Petra Kaufmann, Darryl De Vivo, Ashwini Rao

Anterior Horn: GeneticsP04.061 A Novel BSCL2/Seipin Variant Associated with Atypical Silver Syndrome Mimicking ALS Jennifer Michaels, Thomas Winder

P04.062 Studies of Sequence Changes of the Dynactin p150 Gene In Vitro Marianne Stockmann, Marie Meyer-Ohlendorf, Corinna Hendrich, Tobias Böckers, Albert Ludolph, Stefan Liebau

P04.063 FUS Mutations in a Large Series of Sporadic and Familial ALS Cristina Moglia, Andrea Calvo, Shiao-Lin Lai, Yevgeniya Abramzon, Jennifer Schymick, Rita Guerreiro, Dietrich Stephan, Travis Dunckley, Roberto Mutani, Gabriele Mora, Sara Gallo, Fabio Giannini, Stefania Battistini, Fabrizio Salvi, Ilaria Bartolomei , Cecilia Carlesi, Gabriele Siciliano, Jessica Mandrioli, Patrizia Sola, Claudia Caponnetto, Giovanni Mancardi, Kalliopi Marinou, Maura Brunetti, Amelia Conte, Mario Sabatelli, Francesca Valentino, Vincenzo La Bella, Gioacchino Tedeschi, Maria Rosaria Monsurr≥, Gabriella Restagno , Brian J. Traynor, Adriano Chio

P04.064 Fronto-Temporal Dementia in 3 ALS Families with TARDBP Missense Mutation Andrea Calvo, Cristina Moglia, Michele Balma, Gabriella Restagno, Irene Ossola, Maura Brunetti, Anna Montuschi, Anna Cistaro, Anna Picca, Bryan Traynor, Jennifer Schymick, Roberto Mutani, Giovanna Marrosu, Maria Murru, Giuseppe Borghero , Adriano Chio

P04.065 The Mutational Spectrum of Adult Onset Dominant-Inherited Familial Amyotrophic Lateral Sclerosis in Chinese Population on Taiwan Yi-Chung Lee, Bing-Wen Soong, Ching-Piao Tsai

Peripheral Nerve: Progress in Amyloid NeuropathiesP04.066 Initial Findings from the Transthyretin Amyloidosis Outcomes Survey (THAOS)—A Global Web-Based Registry Violane Plante-Bordeneuve, Teresa Coelho, Bo-Goran Ericzon, Rodney Falk, Sh√-ichi Ikeda, Mat Mauer, Ole Suhr, Pedro Trigo, Donna Grogan

P04.067 Skin Denervation in Amyloid Neuropathy with a Hot-Spot Mutation of Transthyretin (Ala97Ser) in Taiwan Sung-Tsang Hsieh, Ming-Jen Lee, Chi-Chao Chao

P04.068 Outcome Measures for Transthyretin Type Familial Amyloid Polyneuropathy Teresa Coehlo, Ingemar Merkies, Aaron Vinik, Etta Vinik, Jason Chan, Jeff Packman, Donna Grogan

P04.069 Post-Liver Transplant ATTR Val30Met Patients: CNS Clinical Phenotype Luis Maia, Sara Cavaco, Manuel Pires, Joel Freitas, Daniel Dias, Helena Miranda, Rui Magalhães, Manuel Correia, Teresa Coelho

Headache and Facial PainP04.001 Reversible Hypohidrosis with Topiramate Therapy for Chronic Migraine Shira Markowitz, Matthew Robbins, Clair Cascella, Huma Sheikh, Brian Grosberg

P04.002 Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis (HaNDL): Could It Be an Autoimmune Disease? Gülsen Akman-Demir, Erdem Tüzün, Dilaver Kaya, Burçak Vural, Elif Ugurel, Sema Içöz, Mefküre Eraksoy, Angela Vincent, Mustafa Ertas, Murat Kürtüncü

P04.003 Application of the Kano Methodology for Evaluating Migraine Treatment Expectations Among Neurologists in Spain. The MIGREXX Study Jorge Matias-Guiu, Gonzalo Nocea, Teresa Caloto

P04.004 High Migraine Frequency May Be Associated with Increased Interictal Platelet Activation in Episodic Migraine Jill Jesurum, Cindy Fuller, Sylvia Lucas, Natalia Murinova, Lisa Hales, Elisa McGee

P04.005 Response of SUNCT (Short-Lasting Unilateral Neuralgiform Headaches with Conjunctival Injection and Tearing), SUNA (Short-Lasting Unilateral Neuralgiform Headaches with Autonomic Symptoms) and Primary Stabbing Headaches to Occipital Nerve Stimulation (ONS) Juana Marin, Peter Goadsby

P04.006 Lifetime Anxiety Symptoms in Migrainous Vertigo Gulden Akdal, Birgul Balci, Aysegül Ozer, Elif Onur

P04.007 Evaluation of Efficacy and Safety of MAP0004 in Reversing Central Sensitization and Treating Migraine in Established Allodynic Patients Stewart Tepper, Shashidhar Kori, Scott Borland, Min Wang, Bin Hu, Stephen Silberstein

P04.008 The Timing of Gastric Stasis in an Acute Migraine and Its Impact on Treatment Shashidhar Kori, Sheena Aurora

P04.009 Occipital Neuralgia as an Isolated Symptom of Bone Metastasis Caused by Hepatocellular Carcinoma Myung-Goo Ji, Nam Hee Kim

P04.010 Posttraumatic and Postsurgical Nummular Headache Brian Grosberg, Jelena Pavlovic, Matthew Robbins, Uri Napchan, Seymour Solomon, Richard Lipton

P04.011 Clinical Phenotypes and Morphological Changes of the Circle of Willis in Migraineurs Ken Ikeda, Hirono Ito, Konosuke Iwamoto, Kiyoko Murata, Yuji Kawase, Osamu Kano, Kiyokazu Kawabe, Hiroaki Iguchi, Yasuo Iwasaki

P04.012 Syncopal Migraine: Migraine as a Cause of Syncope David Curfman, Michael Chilungu, Robert Daroff, Amer Alshekhlee, Gisela Chelimsky, Thomas Chelimsky

P04.013 Putative Clinical, Mechanical and Local Paracrine Mechanisms of Pituitary Adenoma-Attributed Headache Christoph Schankin, Markus Krumbholz, Anna Kristin Reifferscheid, Jennifer Linn, Walter Rachinger, Petra Sostak, Thomas Arzberger, Andreas Straube

P04.014 Spinal Subdural Collection in the Setting of a Spontaneous Cerebrospinal Fluid Leak Vera Fridman

P04.015 The Headache Under-Response to Treatment (HURT) Index: An Instrument Developed by the “Lifting the Burden” Campaign To Improve Management of Headache, Especially in Primary Care Dawn Buse, Timothy Steiner, Daniel Serrano, Michael Reed, Richard Lipton

P04.016 Scleral Buckle as a Unique Cause of Facial Pain Babak Movassaghi, David Watson

P04.017 Determinants of Migraine-Related Disability Richard Lipton, Andrew Blumenfeld, Jack Ishak, Sepideh Varon, Ariane Kawata, Aubrey Manack, Dawn Buse, Peter Goadsby

P04.018 Magnetic Resonance Perfusion Imaging in Hemiplegic Migraine Sirinan Tazen, C. Haynes Ralsten, Margaret Jaynes, David Watson

P04.019 Migrainous Vertigo Presenting in the Perimenopause Jan Brandes, Susan Roberson, Mark Bennett, David Haynes

Behavioral Neurology: Language and PraxisP04.020 Spatial Vision, Intellectual Loss, and Neuroimaging Variables as Predictors of Constructional Apraxia in Patients with Cerebrovascular Disease Daniel Capruso, Patrick Pullicino, Kerry Hamsher

P04.021 Spatially Adherent Graphemic Perseveration Waldo Guerrero, Kenneth Heilman, Abhay Kumar, Anuali Khaku

P04.022 Atypical Presentation of Cerebellar Mutism in an Adult Tina Lin, May Kim

P04.023 Effect of Education on Severity of Language Dysfunction After Stroke Marlis Gonzalez-Fernandez, Cameron Davis, John Molitoris, Argye Hillis

P04.024 Narrative Discourse in Parkinson Disease Sharon Ash, Rachel Goldmann Gross, Brianna Morgan, Ashley Boller, Andrew Siderowf, Murray Grossman

P04.025 You Don’t Say: A New Variant of PPA? Kirk Daffner, Scott McGinnis, Daisy Sapolsky, Bradford Dickerson

P04.026 Quantifier Comprehension in Corticobasal Syndrome and Frontotemporal Degeneration Brianna Morgan, Rachel Goldmann Gross, Corey McMillan, Ashley Boller, Murray Grossman

P04.027 Extrapyramidal Signs in Primary Progressive Aphasia Sarah Kremen, Mario Mendez, Po-Heng Tsai, Edmond Teng

P04.028 Impaired Decision-Making Strategies for Pronoun Resolution in Behavioral-Variant Frontotemporal Dementia (bvFTD) Megan Reilly, Corey McMillan, Robin Clark, Murray Grossman

P04.029 Language Circuits Investigated with Semantic Decision/Tone Decision fMRI Task and Independent Component Analysis (ICA) Kwang Ki Kim, Prasanna Karunanayaka, Michael Privitera, Christi Banks, Scott Holland, Jerzy Szaflarski

Ten posters in six neurologic topics have been selected for discussion. Posters will be grouped in a separate area where topic experts will facilitate questions and answers with attendees and poster authors during the 90-minute author standby time.