Specially developed to maintain

healthy blood sugar levels*

Standardized Extract of

Syzygium cuminiSyzygium cumini

What is Syzygium cumini?

Syzygium cumini (L.) Skeels (myrtaceae)

commonly known as “jamun” is widely used in

Ayurveda and other Indian folk medicines for the

treatment of diabetes mellitus.

Syzygium cumini seed extract

A natural way to maintain healthy

blood sugar levels

Traditional evidence

Clinical evidence

Pre-clinical evidence

Additional benefits of Syzygium cumini seed

extract in diabetes

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The seeds of Syzygium cumini are used by the

Ayurvedic physicians (and also in Indian folklore) 3in the management of diabetes mellitus

Seed powder Syzygium cumini has significantly 4-5reduced both fasting and postprandial blood sugar.

Several preclinical studies indicate beneficial

effects of seed extract of Syzygium cumini in 6-11controlling blood sugar levels.

Syzygium cumini seed extract stimulates insulin

secretion in isolated islets of langerhans from normal

as well as from diabetic animals and also inhibited 12insulinase activity from liver and kidney.

13-14Exhibits hypolipidemic effect in diabetic rats.

15Reduces tissue damage in diabetic rat brain.

Prevents the cataract development in diabetic 16rats.

Attenuates the progression of renal damage in 17diabetic mice.

Jamun

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2000 2030

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Diabetes mellitus (high blood sugar levels), is

one of the oldest metabolic disorders known to

mankind.

All the renowned classic texts of Ayurveda like

Charaka Samhita (1000 B.C.), Sushruta Samhita

(600 B.C.) and subsequent works refer to this

disorder under the term Madhumeha (meaning

sugar in the urine).

Ayurvedic physic ians have treated

Madhumeha for thousands of years using a

combination of regulated lifestyle and herbal

drugs.

In recent years, scientists in their search for

alternative medicine to manage healthy blood

sugar levels have performed detailed

investigations on several herbs used traditionally

in Ayurveda.

2Diabetes mellitus and Ayurveda

Global Prevalence of Diabetes

The total number of people with diabetes is projected to rise from 171 million in 2000 to 366

1million in 2030.

Syzygium cumini[ Jamun ]

Oral administration of Syzygium cumini seed extract

(SCE-100 mg/kg) caused a significant decrease in the

blood glucose level in diabetic rats. The effect was 15better than glibenclamide (600 µg/kg).

Safety

Regulatory status

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There have been no adverse side effects

associated with consumption of Syzygium cumini

The animal studies do not seem to indicate any

major adverse effects associated with the use of

Syzygium cumini seed extract.

Moreover, Syzygium cumini has a long history of

use in India as food and also as medicine in

traditional Indian systems of medicine.

Syzygium cumini is official in Ayurvedic

Pharmacopoeia of India. It is also listed in, German

Commission E monograph, MHRA-UK, Herbs of

Commerce- American Herbal Products Association

(AHPA).

Why Syzygium cumini seed extract from

Natural Remedies?

Availability

Dose

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Chemical standardization based on content of

ellagic acid and polyphenols.

Manufactured in a GMP and ISO 9001 - 2000

certified manufacturing facility.

The Product is Kosher and Halal Certified.

Syzygium cumini seed extract standardized to >2%

w/w ellagic acid and >20% w/w polyphenols.

Standardized Syzygium cumini seed extract can be

custom formulated.

1500 - 3000 mg/day/adult in divided doses

Standardized Syzygium cumini seed extract can be

incorporated in nutraceutical formulations intended

to maintain healthy blood sugar levels.

Plot No. 5B, Veerasandra Industrial Area, 19th Km Stone, Hosur Road, Electronic City Post,Bangalore - 560 100. INDIA , Ph : +91 80 4020 9999 / 98 / 97 / 96, Fax : +91 80 4020 9817Email: info@naturalremedy.com

*Disclaimer : “These statements have not been evaluated by the Food and Drug Administration or any other regulatory body. This product is not intended to diagnose,

treat, cure or prevent any disease”.

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Normal DiabeticControl

Diabetic + SCE Diabetic +glibenclamide

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cose

(mg/d

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References

1. Sarah W et al., Diabetes Care, 2004: 27: pp 1047 - 1053.

2. Charaka Samhita Vol II. Chikitsasthana. P.V. Sharma (1983),Chaukhamba Orientalia, Varanasi (India), pp. 118.

3. P. Stanely et al., J of Ethanopharmacol. 2004: 91: pp 209-213.

4. Sepaha GL and Bose SN. J Indian Med Assoc. 1956: 27: pp 388.

5. Srivastava Y et al., Asian Med J. 1983: 26 (7): pp 489.

6. Prince PS et al., J Ethnopharmacol. 1998 : 61(1) pp 1-7.

7. Vikrant V et al., J Ethnopharmacol. 2001 : 76(2) pp 139-143.

8. Grover JK et al., J Ethnopharmacol. 2000 : 73(3) pp 461-470.

9. Kar A et al., J Ethnopharmacol. 2003 : 84(1) pp 105-108.

10. Ravi K et al., J Med Food. 2004: 7(2):pp 187-191.

11. Ravi K et al., Biol Trace Elem Res. 2004: 99(1-3):pp 145-155.

12. Achrekar S et al., In Vivo. 1991: 5 (2): pp 143- 147.

13. Ravi et al., Food Chem Toxicol. 2005: 43(9): pp 1433-1439.

14. Sharma SB et al., J Ethnopharmacol. 2003 : 85(2-3) pp 201-206.

15. Stanely P et al., J Ethnopharmacol. 2003 : 84(2-3) pp 205-209.

16. Rathi SS et al., Phytother Res. 2002 : 16(8) : pp 774-777.

17. Grover JK et al., J Ethnopharmacol. 2001 : 46(3) pp 233-238.

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