2007

Receptor binding activityX 0280 Structure—Activity Relationships of Xanthocillin Derivatives as Thrombopoietin

Receptor Agonist. — Syntheses and bioassay are given. The results of the latter sug-gest the importance of the alkene geometry, the presence of hydrophobic substituents at the benzene rings, and the moderate molecule size. All active compounds [cf. (I) and (II)] show inhibition of cell proliferation at high concentration. — (YAMAGUCHI, T.; MIYAKE, Y.; MIYAMURA, A.; ISHIWATA, N.; TATSUTA*, K.; J. Antibiot. 59 (2006) 11, 729-734; Dep. Chem., Sch. Sci. Eng., Waseda Univ., Shinjuku, Tokyo 169, Japan; Eng.) — H. Haber

17- 220