SUBJECT INDEX ABSORPTION (1) ACIDOSIS (7)jpet.aspetjournals.org/content/jpet/131/3/local/back-matter.pdfABSORPTION (1) ACIDOSIS (7) adrenocortical hormones 8453 central nervous system

ABS -ADR

(7)ABSORPTION (1) ACIDOSIS

adrenocortical hormones 8453 central nervous system 8493

anionic agents 8495 C02 inhalation 8493

benzomethamine 8494 drug accumulation 8493

8495 drug penetration 8493

fasted rats 8494 hypercapnia 8493

gastrointestinal tract

omega-haloalkylamines

8454

8496

ACTH (8)

methadone-2-.C14 absorption 8453

intestinal loops 8494 ADRENAL MEDULLA (9)

8496 catecholamine release 8497

intraluminal environment 8495 CC14 hepatotoxicity 8497

male rats 8453 depot fat 84978496

methadone�-2-C14 8453

free fatty acid release

hepatic vasoconstriction

8497

8497

nitrofurantoin 8454 histamine pressor response 8458

organic cations 8495 sympathin release 8458

pH changes 8495 ADRENALECTOMY (10)

pituitary hormone 8453 cardiac phosphorylase

quaternary analogues 8496 activity 8468

small intestine 8494 CC14 hepatotoxicity 8497

8495 8496 cortisone maintenance 8453

unfasted rats 8494 histamine pressor response 8458

8495 methadone absorption 8453

urinary bladder 8454 potassium concentrations 8456

ACETANILID (2) protective action 8497deoxycholate 8449 renal tubular function 8456

liver damage 8449 sodium chloride maintenance 8453

metabolism 8449 sodium concentrations 8456

ACETAZOLAHIDE (3) stop-flow analysis 8456

carbonic anhydrase inhibition 8488 ADRENERGIC BLOCKADE (11)

noncompetitive mechanism

ACETAZOLAMIDE-S35 (4)

8488 cation exchanges

contracting muscle

8471

8471

brain levels 8493 dibenamine 8471

respiratory acidosis 8493 dibenzylene 8471

respiratory alkalosis 8493 phentolamine 8471

selected areas 8493 piperoxan 8471

ACETYLCHOLINE (5) work performance 8471

cerebroside sulfate 8450 ADRENERGIC BLOCKING AGENTS (12)

ganglionic transmission 8480 Cd4 hepatotoxicity 8497

lipid soluble complex 8450 ergotamine tartrate 8497

MAO inhibitors 8480 phenoxybenzamine 8497

stiniulatory action 8480 protective action 8497

ACETYLDIGITOXIN (6) ADRENOCORTICAL HOR1�NES (13)

anti-adrenergic action 8477 methadone absorption 8453

A-V refractory period 8477 methadone disposition 8453

epinephrine chronotropic ADRENOCORTICAL STEROIDS (14)

response 8476 biological potency 8491

heart rate 8476 congeners 8457

pacemaker reactivity 8476 dose-response curves 8457

postganglionic sympathetic 9 alpha-fluorocortisol

stimulation 8476 hemisuccinate 8457

1961

SUBJECT INDEX

S-l

ADR-ANP

hydrocortisone derivatives 8491 brain mitochondrial fractions 845014 alpha-hydroxy-S sodium cerebroside sulfate

succinate 8457 interactions 8450inotropic action 8457 guinea-pig ileum 8450

papillary muscles 8457 histamine response 8450

radioactivity excretion 8491 5-hydroxytryptamine 8450

spirolactone 8457 lipid soluble complexes 8450

structure action relationship 8457 norepinephrine 8450

tissue distribution

triamcinolone-H3

8491

8491

solubility reactions

AMINO ACIDS (22)

8450

AGE (15) L-.1-.ascites tumor cells 8473albino rats 8475 estradiol effect 8487

chemically-induced seizures 8475 glycine-2-C14 8473

potency ratios 8475 plasma levels 8487seizure patterns 8475 protein incorporation 8473

ALCOHOLS (16) rat uterus 8487

inhibitor activity 8469 reserpine effect 8473

liver homogenates 8469 AMINOPYRINE (23)

methanol oxidation 8469 deoxycholate 8449

ALKALOSIS (17) liver damage 8449

central nervous system 8493 metabolism 8449

drug accumulation 8493 8-ANINOTHEOPHYLLINE (24)

drug penetration 8493 blood pressure 8486

hyperventilation 8493 coronary blood flow 8486

hypocapnia 8493 diuretic effect 8486

ALKYLATING AGENTS (18) epinephrine pressor response 8486

anti-tumor effects 8473 hexamethonium pretreatment 8486

chlorambucil 8473 intraduodenal administration 8486

reserpine combination 8473 intravenous administration 8486

thio-TEPA 8473 oral administration 8486

tumor-bearing mice 8473 pharmacologic response 8486

ALVEOLAR AIR (19) sodium arsenate pretreatment 8486

chlorpromazine 8502 sodium salt 8486

controlled pCO� 8502 tolazoline 8486

human subjects 8502 toxicity 8486

meperidine 8502 3-’AMINO-l,2,4-TRIAZOLE (AT) (25)

respiratory effects 8502 blood methanol disappearance 8469

AMIDES, BENZILIC (20) hepatic catalase activity 8469

albino mice 8460 liver homogenates 8469

albino rats 8460 methanol metabolism in vitro 8469

anticonvulsant action 8460 AMIPHENAZOLE (26)

chemical assay 8460 grouped mice 8464

daily administration 8460 mortality 8464

N-substituted derivatives 8460 motor activity 8464

physiological disposition 8460 AMPHETAMINE (27)

structure action relationship 8460 denervated hind limb 8499

tissue concentrations 8460 deoxycholate 8449

toxicity 8460 grouped mice 8464

urinary excretion 8460 heart contractile force 8499

AMINES (21) liver damage 8449

acetylcholine 8450 metabolism 8449

SUBJECT INDEX

VOL. 131

S-2

(28)

(35)

(29)

(30)

metrazol seizure test

N-ethyl derivatives

pentylenetetrazol extensor

seizures

protective index

ANTIEMETIC AGENTS (36)

apomorphine-induced emesis

8502

8502

8501

8502

8502

8501

8501

8501

8502

8501

8504

8504

8504

8504

8504

8504

8504

8504

8504

8504

8504

8468

8468

8468

8468

8448

8474

8474

8460

8474

8460

8460

8460

8460

8474

8460

8466

8466

8466

8466

8459

8459

8453

8453

8453

8473

8473

8474

8474

8459

8459

8499

8499

8499

8499

8499

8499

8499

8499

8499

(37)

(38)

(39)

(40)

(41)

(42)

(31)

(32)

(33)

(34)

isoproterenol inhibition

methylphenidate

norepinephrine augmentation

rabbit aortic strips

tyramine suppression

ATROPINE (43)

8477 acetylcholine response 8481

8477 inhibitor activity 8481

isolated muscle preparations 8481

8448 nerve stimulation response 8481

8448 slow intravenous infusion 8481

8448 steady nerve block 8481

1961

SUBJECT INDEX

ANP-ATR

S -3

methylphenidate antagonism

mortality

motor activity

pressor effect

vasoconstrictor action

ANALGESIA

adrenocortical hormones

methadone absorption

ANALGESICS

alveolar pCO2 control

chiorpromazine interactions

dextroniorami de

human subjects

meperidine

morphine

placebo administration

relief measurement

respiratory depression

statistical analysis

ANAPHYLACTOID REACTIONS

2-brom-lysergic acid

diethylamide

chlorpromazine

edema formation

egg-white induced

Evans blue dye accumulation

phenelzine

polymyxin-Bprotective agents

pyrilamine pretreatment

rat tissues

re serpine

ANESTHESIA

cardiac phosphorylase

activity

ether

pentobarbital

sympathetic activity

ANIONIC AGENTS

butyric acid effect

intestinal absorption

intraluminal environment

pH changesphenolsul fonphthalein

ANTI -ADRENERGIC AGENTS

A-V refractory period

cardiac glycosides

ANTIBIOTICS

cell wall synthesis

E. coli

penicillin

8499 5. aureus

8464 ANTICONVULSANTS

8464 albino mice

8499 anti-reserpine effects

8499 benzilic amides

diphenylhydantoin

8453 electroshock threshold

8453 NES test

8495

8495

8495

84958495

fluphenazine

phenothi azines

relative potencies

ANTIHISTANINES

cyproheptadine

reference agents

ANTI -INFLANMATORY AGENTS

analgesia

corti sone


ANTI -NEOPLASTIC AGENTS

reserpine

tumor-bearing mice

ANTI-RESERPINE ACTIONS

albino mice

centrally acting agents

ANTISEROTONINS

cyproheptadine

reference agents

AORTA, ISOLATED

amphe t amine

catechol influence

histamine

iproniazid influence

BAC -BLO

BACTERIA (44) lactic acid content 8471

cell wall synthesis 8448 methanol concentrations 8469

E. coli 8448 methanol disappearance rate 8469

penicillin

S. aureus

8448

8448

sodium tungstate

triamcinolone-H3

8469

BENZONETHAMINE (45) concentration 8491

amino acids 8495 BLOOD FLOW (51)

bile 8495 bradykinin 8500

bile salts 8495 femoral artery 8500

calcium chloride 8495 kallidin 8500

chondroitin sulfate 8495 peripheral vascular bed 8500

dose-absorption curves 8494 BLOOD PRESSURE (52)

experimental procedures 8494 acetylcholine response 8481

fatty acid facilitation 8495 8-aminotheophylline 8486

hyaluronic acid 8495 amphetamine 8499

intestinal absorption 8494 anesthetized cats 8458

8495 anesthetized dogs 8481

intraluminal environment 8495 8486

protamine 8495 anesthetized rats 8500

quaternary ammonium compound 8494 angiotensin response 8498

sodium metaphosphate 8495 atropine infusion 8481

sorbitol 8495 atropine pretreatment 8498

3 -BENZOYL-4-HYDROXY-6-METHOXY- bradykinin 8500

BENZENESULFONIC ACID (BsA)(46) central sciatic stimulation 8498

albino rats 8503 central vagal stimulation 8498

8-methoxypsoralen injection 8503 C-O pressor response 8498

protective effects 8503 cyproheptadine influence 8459

topical application 8503 depressor effect 8486

ultraviolet irradiation 8503 3 ,4dihydroxyphenylpyruvate 8492

BENZTHIAZIDE (47) dopa 8492

carbonic anhydrase inhibition 8488 dopamine 8492

1 -BENZYL-2-ETHYL-5-METHOXY- drug modification 8458

TRYPTAMINE (BAS) (48) epinephrine 8459

cyproheptadine comparison 8459 ganglionic blockade 8459

inhibitor activity 8459 guanethidine intravenously 8498

rat uterus 8459 HCS inhibitor effect 8492

serotonin pressor response 8459 histamine 8458

serotonin-induced contraction 8459 rn-hydroxyphenylpyruvate 8492

BLADDER (49) kallidin 8500

anesthetized dog 8481 methylphenidate 8499

atropine blocking action 8481 nerve stimulation response 8481

pelvic nerve stimulation 8481 norepinephrine 8459

BLOOD (50) norepinephrine i.v. infusion 8498

adrenergic blockade 8471 norepinephrine response 8498

3-amino-l,2,4-triazole 8469 phentolamine pretreatment 8498

ammonia levels 8470 pilocarpine 8458

contracting skeletal muscle 8471 pressor response 8458

ethanol 8469 8459 8498

glutamylhydrazine effect 8470 pyridoxine deficiency 8492

hydrazine effect 8470 reserpine pretreatment 8498

intravenous injection 8491 secondary rise 8458

SUBJECT INDEX

VOL. 131

S -4

8459

8458

8498

8498

8498

84928498

8464

8464

8464

8464

8500

8500

8504

8504

8493

8493

8493

8493

8493

8493

8493

(61)

(62)

(53)

(54)

(55)

meperidine

respiratory effects

(64) 8488

8488

84888488

8488

8488

(65)

8499

8498

8498

8499

8499

8498

8499

8499

1961

SUBJECT INDEX

BLO-CAS

S -5

serotonin

spinal cats

spinal cord section

TEA pretreatment

tyramine response

rn-tyramine

vagotomy

BODY TEMPERATURE

CNS stimulants

grouped mice

lethal effects

motor activity

BRADYKININ

assay procedures

kallidin comparison

BRAIN

amine interactions

cerebroside sulfate

guinea-pig ileum

lipid extracts

mitochondrial fractions

potassium-K42 binding

BRETYLIUM �-TOLUENESULFONATE(56)


activity

isolated perfused rat heart

postganglionic sympathetic

blockade 8468

BRUCINE (57)

albino rats

convulsant effects

maturation influence

toxic effects

CAFFEINE (58)

anticonvul sant s

CNS stimulants

grouped mice

MAO inhibitors

mortality

motor activity

reserpine-.induced seizure

facilitation

tonic extensor seizures

CALCIUM (59)

kidney uptake

pilocarpine effect

submaxillary gland uptake

CAPILLARIES (60)

Evans blue dye accumulation 8504

permeability changes

tissue plasma volume

CARBON DIOXIDE

blood pH

central nervous system

drug accumulation

drug penetration

radioactivity measurements

respiratory acidosis

respiratory alkalosis

CARBON DIOXIDE TENSION

alveolar air

chlorpromazine

controlled pCO2

8502

8502

8502

8502

8502

8450 simultaneous administration 8502

8450 CARBON TETRACHLORIDE (63)

8450 adrenalectomy 8497

8450 adrenergic blocking agents 8497

8450 BSP retention 8490

8450 female rats 8497

hepatotoxicity 8497

hexobarbital sleeping time 8490

8468 liver function 8490

8468 liver hemodynamics 8497

microsomal enzyme activity 8490

microsomal-depressing agent 8490

phenobarbital-induced changes 849t)

8475 spinal transection 8497

8475 urethan-induced changes 8490

8475 CARBONIC ANHYDRASE INHIBITION

8475 acetazolamidebenzthiazide

catalyzed CO2 hydration

equilibration rates

8474 pH-stat

8474 reversibility

8464 CARDIOVASCULAR SYSTEM

8474 arterial tissue

8464 blood pressure

8464 8499guanethidine

8474 heart

8474 methylphenidate

peripheral effects

8485 peripheral vascular

8485 resistance

8485 vasoconstrictor responses

CASEIN (66)

hydrazine inhibition 8470

VOL. 131

(68)

(69)

8495

8495

8495

8448

8448

8448

8448

8448

8448

8464

8461

8474

8475

8461

8461

8463

8461

8464

8493

8463

8464

8464

8465

8465

8474

8462

8493

8461

8461

8463

8462

8493

8461

8462

8465

8475

8464

8465

8493

8461

8465

8493

8450

8450

8450

8450

8455

8455

8459

8459

8459

8459

8465

8493

8462

8464

8493

8493

8493

8493

8493

8475

8493

8474

8493

8463

8493

8493

8465

8474

8464

8462

8463

8493

8464

(71)

(72)

(73)

SUBJECT INDEX

S -6

CAS -CHL

methylhydrazine inhibition

peptic hydrolysis

CATIONS (67)

adrenergic blocking agents

contracting muscle in situplasma electrolytes

transfer movements

CATIONS, ORGANIC

benzomethamine



CELLS, BACTERIAL

basal structure synthesis

E. coli

isotopic precursor

incorporation

nucleic acidpenicillin influence

protein

S. aureus

special structure synthesis

wall structure

CENTRAL NERVOUS SYSTEM (70)

albino mice

albino rats

8475anti-reserpine effects

aspirin

autoradiograms

behavior responses

8465

body temperature

brain levels

brain regions

carbon dioxide effect

cat brain

cerebral blood flow

convul sant s

C.S.F. levels

d-desoxyephedrine

differential accumulation

discriminative behavior

drug distribution

drug penetration

escape performance

excitantsgrouped mice

5 -hydroxytryptophan

inappropriate responses

intravenous injections

isolated mice

8470 lethal toxicity

8470 levallorphan antagonism

lysergic acid diethylamide

8471 maturation influence

8471 medullary respiratory centers

8471 meperidine effect

8471 monkeys

morphine

8465

motor activity

myelination

nitrous oxygen: oxygen

8448 oral administration

8448 overt behavioral activity

pain tolerance

pentobarbital


seizures

pigeon pecking-performance

plasma ratios

pontile apneustic center

8448 pontile pneumotaxic center

psychological tests

8474 quantitative measurement

8465 respiratory alkalosis

respiratory mechanism

8474 response rate

salicylates

seizure patternsstimulants

timing behavior

tissue binding

vagal reflexes

variable interval performance

vascularity

CEREBROSIDE SULFATE

amine interactions

at ropine

brain mitochondrial

fractions

guinea-pig ileum

CHLORIDE

renal excretion

serotoninCHLORPHENIRANINE

cyproheptadine comparison

egg-white induced edema

histamine-induced

bronchospasm

histamine-induced

vasodepres sion

inhibitor activity 8459 antiserotonin activity 8459

serotonin-induced edema 8459 epinephrine pressor response 8459

CHLORPROMAZINE (74) ganglionic blockade 8459

antiemetic activity 8466 norepinephrine pressor

controlled alveolar pCO2 8502 response 8459

cyproheptadine comparison 8459 reference agents 8459

deoxycholate 8449 SY-2l comparison 8459egg-white induced edema 8459 CYSTEINE (82)

fluphenazine comparison 8466 mercaptomerin pretreatment 8484

human subjects 8502 renal hemoglobin distribution 8484

inhibitor activity 8459

liver damage 8449

meperidine interaction 8502 N-DEMETHYLATION (83)

metabolism 8449 buffer concentration 8489

respiratory effects 8502 glucose 1-phosphate addition 8489

serotonin pressor response 8459 glucose 6-phosphate addition 8489

serotonin-induced edema 8459 isocitrate addition 8489

COCAINE (75) liver microsomes 8489

action mechanism 8483 meperidine 8489

dose-response curves 8483 starved rats 8489

nerve conduction block 8483 substrate concentration 8489

sodium concentration 8483 DEOXYCHOLATE, SODIUM (84)

CODEINE (76) drug metabolism 8449

deoxycholate 8449 inhibitor effect 8449

liver damage 8449 liver enzyme activities 8449

metabolism 8449 DESOXYCORTICOSTERONE (85)

CONTRACTION (77) inotropic action 8457

adrenergic blockade 8471 papillary muscle 8457

cation changes 8471 potassium concentrations 8456

skeletal muscle in situ 8471 renal tubular function 8456

CONTRACTION, HEART (78) sodium concentrations 8456

heart-lung preparation 8478 stop-flow analysis 8456

reserpine pretreatment 8478 DEXTROMORAMIDE (86)

sympathetic nerve stimulation 8478 chronic pain relief 8501

ventricular function curves 8478 morphine comparison 8501

CONVULSIONS (79) placebo administration 8501

albino rats 8475 side effects 8501

blood-CNS barrier 8475 statistical analysis 8501

brain amino acids 8475 H3-DIAMINOPIMELIC ACID (DAP)(87)

carbonic anhydrase activity 8475 E. coli incorporation 8448

chemically induced 8475 penicillin 8448

maturation effect 8475 DIGITALIS (88)

potency ratios 8475 extravagal factor 8477

CORTISONE (80) heart rate 8477

inotropic action 8457 peripheral inhibitor activity 8477

methadone metabolism

methadone-2-’C14 absorption

8453

8453

sympathetic nervous system

DICITOXIN (89)

8477

mineralocorticoid activity 8457 anti-adrenergic action 8477

papillary muscle 8457 A-V refractory period 8477

CYPROHEPTADINE (81) epinephrine chronotropic

antihistaminic activity 8459 response 8476

1961

SUBJECT INDEX

CHL-DIG

S -7

DIG-EPI

heart rate

pacemaker reactivity

postganglionic sympathetic

stimulation

3 , 4-DIHYDROXYPHENYLA.LANINE

(DOPA)

8476 nicotine

8476 nitrogen mustard

perphenazine effect

(90)

8476 veratrum viride

ENZYME INDUCTION (100)

hexobarbital sleeping time

phenobarbital

urethan

ENZYMES (101)

dopa decarboxylase in vivo 8492

HCS pretreatment 8492

pressor effect 8492

3 , 4-DIHYDROXYPHENYLPYRUVIC

ACID (3,4-DHPP) (91)

HCS pretreatment 8492

metabolism Ia !i:.Y.2 8492

pressor effect 8492

DIMERCAPROL (92)

mercaptomerin pretreatment 8484

renal hemoglobin distribution 8484

DIPHENHYDRAMINE (93)

cyproheptadine comparison 8459

histamine-induced

acetazolamine inhibition

AT inhibitor activity

benzthiazide inhibition

carbonic anhydrase


activitycatalase activity

Cd4 hepatotoxicity

N-demethylating system

demethylation inhibitor

deoxycholate inhibition

8459 determination procedure

8459 drug metabolism

glutamic dehydrogenase

activity

magnesium ATP-ase activation

methanol metabolism

monoamine oxidase inhibition

obstructive jaundice

oxidative phosphorylation

perfused rat hearts

fasted hydrated rats

(94)

(95)

(96)

(97)

(98)

(99)

rat heart

serotonin metabolism in vivosuccinoxidase activity

sympathetic activity

tryptamine metabolism in vivo

tungstate inhibitor activity

xanthine oxidase activity

EPINEPHRINE (102)

dose-response curves

intravenous infusion

methylphenidate potentiation

SUBJECT INDEX

VOL. 131

S -8

bronchospasm

inhibitor activity

D lURE S IS

anesthetized rats

bradykinin

kallidin

urine flow

DIURESIS , MERCURIAL

hemoglobin concentration

rat kidney

renal cortex

renal medulla

DIURETICS, XANTHINE

comparative effects

etherized dogs

fasted dehydrated rats

EDEMA , ANAPHYLACTOID

cyproheptadine antagonism

egg white induced

serotonin induced

ELECTROLYTES

renal excretion

serotonin

tubular reabsorption

EMESIS, DRUG INDUCED

apomorphi ne

fluphenazine effect

lanatoside-C

8500

8500

8500

8500

8484

8484

8484

8484

8486

8486

8486

8486

8459

8459

8459

8455

8455

8455

8466

8466

8466

liver damage

liver function

liver microsomes

8489

phosphorylase activity

rat liver homogenates

acetyldigitoxin effect

A-V nodal reactivity

basal cardiac frequency

digitoxin effect

8466

8466

8466

8466

8490

8490

8490

8488

8469

8488

8488

8468

8469

8497

8489

8489

8449

8467

8449

8497

8449

8497

8449

8497

8469

8452

8449

8497

8467

8467

8469

8468

8452

8497

8468

8452

8469

8469

8476

8476

8476

8476

8476

8476

8499

positive chronotropic effect 8476

(103)

(104)

(105)

EPI-GLY

8495

8495

8495

8495

(112)

8466

8466

8466

8466

8468

8459

8458

(114)

(115)

(116)

(117)

(118)

8460

8460

8460

8460

8460

8460

8460

8460

8460

8504

85048504

8504

8504

8504

8504

8504

8504

8472

8472

8472

8472

8454

8454

8448

84488448

8448

8448

8470

8470

8470

8470

8470

8470

8470

8470

8476

84778495 anti-adrenergic action

SUBJECT INDEX

S -9

1961

positive inotropic action

S-A nodal reactivity

ERGOTAMINE TARTRATE

CC14 hepatotoxicity

protective action

ESCHERICHIA COLI

cell wall synthesis

penicillin

ESTRADIOL

free amino acids

rat uterus

ESTROGENS (106)

benzomethamine absorption

8499 butyric acid

8476 propionic acid

small intestine

8497 FLUPHENAZINE (PROLIXIN)8497 antiemetic activity

drug-induced emesis

8448 pentobarbital-induced

8448 depression

phenothiazine comparisons

8487

8487

free amino acids 8487

rat uterus 8487

ETHANOL (107)blood methanol disappearance 8469


methanol metabolism in vitro 8469

ETHIONINE (108)

administration routes 8490

BSP retention 8490


liver function 8490

microsomal depressing agent 8490

microsomal enzyme activity 8490

phenobarbital-induced changes 8490

urethan-induced changes 8490

N-ETHYL-BENZILIC-A.MIDE (109)

anticonvulsant activity

metabolic biotransformation

N-dealkylation

neurological deficit

physiological disposition

protective index

stimulant component

tolerance

toxicity

EVANS BLUE (110)

experimental inflammation

phenel zine

quantitative measurement

recovery experiments

serotonin antagonists

tissue concentrations


tissue space

total plasma volume

FATTY ACIDS (111)

acetic acid

GANGLIONIC BLOCKADE (113)


activity

cryptoheptadine effect

hexamet honi um

8468

histamine pressor response 8458

pilocarpine pressor response 8458

serotonin pressor responses 8459

8458tetramethylarnmonium

GANGRENE

mouse tail

reserpine effect

subcutaneous injection

thiopental induced

GASTROINTESTINAL SYSTEM

isolated segments

nitrofurantoin absorption

GENTIAN VIOLET

cell wall synthesis

E. coli

S. aureus

GLUCOSE -C14

E. coli incorporation

penicillin

L-Gamma -GLUTAMYLHYDRAZINE

blood ammonia levels

enzymatic synthesis

fatty liver production

gamma-glutamyl transferase

activity

hydrazine metabolism

hydrolysis rate

spinal fluid ammonia

urinary hydrazino compounds

GLYCOSIDES, CARDIAC (119)

adrenergic cardiac

acceleration

GLY-HEMSUBJECT INDEX

VOL. 131

S-lO


direct effect

inhibitor activity

vagal action

GUANETHIDINE (120)

action mechanism

anesthetized dogs

blood pressure

cardiovascular effects

catecholamine release

chronic oral administration

intravenous administration

peripheral vascular

resi stance

reserpine-like effects

sympathetic blocking activity

vascular sympathetic

effectors

Ome�a-HAL0ALKYLANINES (121)

cyclization rates


male rats

nictitating membrane

quaternary analogues

unanesthetized dog

urinary excretion

HARNINE (122)

ganglionic blocking action 8480

reversible activity 8480

HEART (123)

accelerator nerve stimulation

acetyldi gi toxin

adrenal ligation

amphetamine response


bretylium

cardiac rate

contractile force

8499denervation

epinephrine infusion

epinephrine response

hexamethoni um

intact rat heart

methylphenidate influence

norepinephrine response

open-chest dogs

8499

8477 perfused isolated rat heart 8468

8477 phosphorylase a activity 8468

8476 rate changes 8477

8477 sympathetic activity 8468

thoracic sympathectomy 8477

8498 vagotomy 8477

8498 8499

8498 HEART AURICLES (124)

8498 isolated rabbit atria 8479

8498 microelectrode technique 8479

8498 quinidine effect 8479

8498 single cell records 8479

sodium lactate reversal 8479

8498 HEART, ISOLATED (125)

8498 AMP content 8467

8498 1-epinephrine 8467

freezing procedure 8467

8498 isometric systolic tension 8467

perfused rat heart 8467

phosphate determinations 8467

phosphorylase a activity 8467

resin treatment 8467

8496 tissue extracts 8467

8496 total phosphorylase activity 8467

8496 HEART MUSCLE (126)

8496 heart-lung preparation 8478

8496 myocardial contractility 8478

8496 pentobarbitalized dogs 8478

8496 reserpine pretreatment 8478

sympathetic nerve stimulation 8478

ventricular function curves 8478

HEART MUSCLE, ISOLATED (127)

adrenocortical steroids 8457

8477 cat papillary muscle 8457

8477 inotropic effect 8457

8477 structure action relationship 8457

8499 HEART RATE (128)

8477 anesthetized dogs 8476

8468 basal frequency 8476

8468 cardiac glycosides 8476

8468 denervated preparation 8476

epinephrine-induced

8477 acceleration 8476

8477 pacemaker reactivity 8476

8499 sympathetic nerve stimulation 8476

8468 HEMOGLOBIN (129)

8468 chlorothiazide 8484

8499 �-hydroxymercuribenzoate 8484

8499 kidney distribution 8484

8477 mercurial diuretics 8484

water diuresis 8484

HEXAJIETHONIUN


activity

ganglionic blockade

isolated perfused rat heart

HEXOBARBITAL (131)

adult rabbits

deoxycholate

liver damage


sleeping time

HEXOBARBITAL HYPNOSIS (132)

action modificationalbino mice

biotransformation rate

CC14 influence

ethionine influence

liver microsomal enzymes

phenobarbital -induced

shortening

sleeping time

urethan-induced shortening

HISTAMINE (133)

adrenalectotny

anesthetized cats

cerebroside sulfate

chlorpheniramine antagonism


ganglionic receptors

ganglionic stimulant action

hexamethonium pretreatment

lipid soluble complex

methadone

morphine

nicotine

pressor response

reserpine pretreatment

spinal catsTEA

TMA

tyramine comparison

vasodepressor effect

HISTAMINE LIBERATION (134)

compound 48/80


HYDRAZINE

blood ammonia values

fatty liver production

glutamylhydrazine injection

peptic hydrolysis inhibition

urinary excretion

8470

8470

8470

8470

8470

8504

8504

8504

1961

SUBJECT INDEX

HEX-INF

5-11

(130) HYDROCORTISONE-4-C14 (136)

hydrocortisone derivatives 8491

8468 intravenous injection 8491

8468 metabolism in vitro 8491

8468 plasma half-lives 8491

tissue distribution 8491

8449 urinary excretion 8491

8449 HYDROXINDASOL (137)

8449 cyproheptadine comparison 8459

8449 egg-white induced edema 8459

8449 inhibitor activity 8459

rat uterus 8459

8490 serotonin pressor response 8459

8490 serotonin-induced contraction 8459

8490 serotonin-induced edema 8459

8490 5 -(3 -HYDROXYCINNAMOYL)

8490 SALICYLIC ACID (HCS) (138)

8490 blood pressure 8492

dopa decarboxylase inhibitor 8492

8490 hydroxyphenylpyruvic acid

8490 .&.a� 8492

8490 3-HYDROXYPHENYLPYRUVIC ACID

(3-HPP) (139)

8458 HCS pretreatment 8492

8458 metabolism in vivo 8492

8450 pressor effect 8492

8459 5-HYDROXYTRYPTAMINE (140)

8459 antagonists 8504

8458 cerebroside sulfate 8450

8458 electrolyte excretion 8455

8458 Evans blue dye accumulation 8504

8450 experimental inflammation 8504

8458 female dogs 8455

8458 lipid soluble complex 8450

8458 rat tissues 8504

8458 renal hemodynamics 8455

8458 water excretion 8455

8458 5-HYDROXYTRYPTOPHAN (141)

8458 behavioral effects 8462

8458 central nervous system 8462

8458 dose-response curves 8462

8459 intramuscular injections 8462

neurochemical correlates 8462

8453 pigeons 8462

8453 serotonin precursor 8462

(135)

INFLAMMATION , EXPERIMENTAL (142)

Evans blue dye accumulation

phenel zine

serotonin antagonists

8504 blood flow

(143) Ca45 uptake

male rats

mercurial diuretics

pilocarpine effect

renal hemodynamics

(144)

(145)

(146)

8495

8494

8495

8494

8494

8495

8495

8494

8494

8494

8495

8495

8494

8494

8495

8474

8480

8452

8485

8485

8484

8455

8485

8484

8484

8485

8484

8484

8485

8455

8455

8484

8484

8455

8456

8456

8456

8456

8456

8456

8456

8456

8456

8456

8456

8456

(151)

(152)

glutamylhydrazine injection

(148) hydrazine administration

84498449

8449

8449

8449

8500

8500

(154)

8461

mechanism 8461

8461

8461

(153)

8470

8470

8470

8449

8497

8497

8497

8449

8449

8497

8497

8497

8497

(149)

(150)

SUBJECT INDEX

VOL. 131

S-l2

INF-LIV


INOTROPISM

adrenocortical steroids

papillary muscles

INTESTINE, ISOLATED

amine interactions

brain-lipid fractions

guinea-pig ileum

INTESTINE, SMALL

absorption .�:.!! :Y.tY.2

added intestinal mucus

anionic agents

benzmethamine absorption

dose effects

intestinal loops


loop preparations in vivolumen perfusion

mechanical manipulation

organic cations

pH changes

segment locations

unanesthetized rats

unfasted rats

IPRONIAZID

anti-reserpine effect

ganglionic blocking action

MAO inhibitor activity


seizure

reserpine-induced ptosis

reserpine-induced seizure

facilitation

serotonin metabolism in vivotryptamine metabolism in vivo

ISONIAZID (147)

ganglionic transmission

JAUNDICE , OBSTRUCTIVE

adult rabbits

drug metabolism in vitro


liver damage

liver homogenates

KALLIDIN

assay procedures

bradykinin comparison

KIDNEY

acidifying salts

alkalinizing salts

8457 chlorothiazide

8457 electrolyte excretion

fractional distribution

8450 hemoglobin distribution

8450 �-hydroxymercuribenzoate

8450 K42 uptake

8474

8474

serotonin

urine flow

water diuresis

water excretion

KIDNEY TUBULAR FUNCTION

adrenalectomy

desoxycorticosterone

distal reabsorption

inulin concentrations

male rats

PAR concentrations

potassium concentrations

proximal reabsorption

sodium concentrations

stop-flow analysis

ureteral catheterization

urine flow

LEVALLORPHAN

8474 antagonist activity

8452 central respiratory

8452 meperidine effect

morphine effect

8480 LIVER

lipid content

LIVER DAMAGE

adult rabbits

biochemical events

carbon-tetrachloride induced

centrilobular necrosis

drug enzyme systems

drug metabolism

enzyme activity

fatty infiltration

8484 female rats

8484 histopathologic findings

8-methoxypsoralen injection 8503


protective treatment

deoxycholate inhibition

8449 dopa decarboxylase inhibitors

8497 dopa formation

tissue homogenates

ultraviolet irradiation

LIVER MICROSOMES (155)

N-demethylating system

demethylation inhibitor

separated microsomes

starved rats

supernatant fraction

supplementation effect

tissue homogenates

LYSERGIC ACID DIETHYLAMIDE (156)

8449 dopamine formation

8503 enzymatic degradation

enzymatic N-demethylation

enzyme activity8489

8489

8489

8489

84898489

8489

8449

8492

8492

8492

8454

8489

8469

8470

8492

8449

j:�_gaflZfl��glut amylhydrazine

HCS pretreatment


8490

8470

8491

hydrazine

hydrocortisone derivatives

hydroxyphenylpyruvic acid

in vivo

liver damage

liver enzyme activities

liver homogenates

8469

cyproheptadine comparison 8459 8492

egg-white induced edema 8459 8449

inhibitor activity 8459 8449

rat uterus 8459 8449

serotonin pressor response 8459

serotonin-induced liver microsomal enzymes 8490

contractions 8459 liver microsomes 8489

serotonin-induced edema 8459 MAO inhibitors 8452

LYSINE-C14 (157) meperidine 8489

gentian violet 8448 methadone-2-C14 8453

penicillin

S. aureus incorporation

8448

8448

methanol

methocarbamol-C14

microsomal-depressing agents

8469

8451

8490

MEPERIDINE (158) microsomal-stimulating agents 8490

central respiratory mechanism 8461 nitrofurantoin 8454

chlorpromazine interaction 8502 obstructive jaundice 8449

controlled alveolar pCO2 8502 pithed cats 8492

N-demethylation 8489 pithed rats 8492

human subjects 8502 pituitary hormone 8453

levallorphan antagonism 8461 plasma half-lives 8491

liver microsomes 8489 pyridoxine deficiency 8492

respiratory effects 8502 serotonin 8452

starved rats 8489 starved rats 8489

MERCAPTOMERIN (159) studies in vivo 8452

cysteine 8484 tissue slices 8454

dimercaprol 8484 transamination reaction 8492

kidney weight 8484 triamcinolone 8491

renal cortical hemoglobin 8484 tryptamine 8452

renal medullary hemoglobin 8484 rn-tyramine formation 8492

METABOLISM, DRUG rn-tyrosine formation 8492

adrenocortical hormones 8453 urinary excretion 8451

adult rabbits 8449 8491

anesthetized dogs 8451 urine pH 8451

blood pressure responses 8492 urine volume 8451

cl4 recovery 8451 whole mouse 8452

chromogenous compounds 8451 METHADONE (161)

decarboxylation 8492 absorption 8453

(160)

1961

SUBJECT INDEX

LIV-MET

5-13

8453

8453

8453

8453

8453

8453

8464

8499

8499

(162)

(163)

8469

8469

8469

8469

8469

8469

8469

8469

8469

8469

8451

8451

8451

8451

8451

8451

8451

8451

8503

8503

8503

8503

8503

8503

8503

8503

8503

8503

8503

8503

8503

84998499

8499

8499

8464

8464

8471

8471

8471

8471

8471

8471

8471

8471

8471

8471

8471

8471

8471

8471

8459

8500

8500

8459

8459

8500

8500

(171)

MET-MUS

SUBJECT INDEX

VOL. 131

5-14

adrenocortical hormones

�14 labeled

metabolism

pituitary hormone

tissue distribution

urinary metabolites

METH.ANPHETAMINE

grouped mice

mortality

motor activity

METHANOL

alcohols

3-amino-l,2,4-triazole (AT)

blood concentration

catalase activity

competitive antagonists

ethanol antagonism

liver homogenates

peroxidative metabolism

sodium tungstate


METHOCARBA�L (164)

C14 labeled

chromogenous metabolites

excretion

gastrointestinal absorption

human subjects

metabolism

placental transfer

tissue distribution

8 -METHOXYPSORALEN (165)

adrenalectomy

albino mice

albino rats

BSA pretreatment

experimental poisoning

hypophysectomy

liver damage

ovari ectomy

pathological changes

photosensitizing properties

pregnancy

toxicity

ultraviolet irradiation

METHYLPHENIDATE (166)

amine interactions

amphetamine antagonist

arterial tissue

cardiovascular system

grouped mice

mortality

motor activity

nictitating membrane

receptor mechanism

MONOAMINE OXIDASE (167)

inhibition 8452

serotonin metabolism in vivo 8452

tryptamine metabolism in vivo 8452

8464 MONOAMINE OXIDASE INHIBITORS

8464 albino mice (168) 8474

8464 anesthetized cat 8480

anti-reserpine effects 8474

ganglionic transmission 8480

iproniazid 8474

i sopropylhydrazine 8474


seizures 8474

beta-phenylisopropylhydrazine 8474

MORPHINE (169)

central respiratory mechanism 8461

chronic pain relief 8501

dextromoramide comparison 8501

levallorphan antagonism 8461

placebo administration 8501

side effects 8501

statistical analysis 8501

MUSCLE, SKELETAL (170)


blood lactic acid

cation changes

contraction amplitude

direct stimulation

indirect stimulation

intracellular potassium

content

intracellular sodium content

intracellular water content

plasma electrolytesrat gastrocnemius in siturat phrenic-nerve diaphragm

in vitro

stimulus duration

stimulus frequency

MUSCLE, SMOOTH

ACh-induced contractions

bradykinin

chicken rectal-cecumcyproheptadine antagonism

guinea pigs

guinea-pig ileum

histamine comparison

MUS -NOR

(178)

C1 72)

(173)

histamine-induced

bronchoconstriction

hydroxindasol antagonism

isolated intestine

kallidin

LSD antagonism

rabbit ileum

rat uterus

8500

reference agents

serotonin-inducedcontractions

MUSCLE SPINDLES

anesthetized cats

discharge frequency

ryanodine pretreatment

sensory endings

succinylcholine response

NARCOTICS

analgesic potency

chlorpromazine interactions

human subjects

meper i dine

respiratory depression

NERVE BLOCK (174)

action mechanism

action potentials

cocaine concentration

competitive antagonism

desheathed nerve trunk

frog sciatic-peroneal nerve

sodium concentration

NERVES (175)

acetylcholine response

atropine blocking action

intramuscular parasympathetic

endings

nerve-bladder strip

rabbit atria

rabbit ileum

sphincter pupillae

steady block

stimulation response

NEUROMUSCULAR JUNCTION (176)


cationic exchanges

contracting skeletal muscle

in situ

NIALAMIDE (177)


(181)

8481

8481

8481

84818481

8481

8481

8471

8471

8463

8463

8463

8463

8463

8463

8463

8463

8463

8499

8499

8450

8499

8499

1961

SUBJECT INDEX

5-15

NICOTINE

8459 competitive phase 8458

8459 depolarization phase 8458

8500 ganglion cells 8458

8500 histamine pressor response 8458

8459 pilocarpine pressor response 8458

8500 NICTITATING MEMBRANE (179)

8459 acetylcholine perfusion 8480

amphetamine 8499

8459 contraction response 8480

dose-response curves 8499

8459 epinephrine response 8499

ganglionic ACh output 8480

8482 omega-haloalkylamines 8496

8482 MAO inhibitors 8480

8482 methylphenidate influence 8499

8482 norepinephrine response 8499

8482 phentolamine blocking action 8499

postganglionic stimulation 8480

preganglionic stimulation 8480

8502 relaxing effect 8496

8502 smooth muscle 8499

8502 tyramine response 8499

8502 unanesthetized animals 8496

8502 NITROFURANTOIN (180)

absorption 8454

8483 distribution 8454

8483 gastrointestinal tract 8454

8483 hepatectomy 8454

8483 metabolism in vitro 8454

8483 nephrectomy 8454

8483 plasma concentration 8454

8483 saliva concentration 8454

uretral ligation 8454

8481 urinary excretion 8454

8481 NITROUS OXIDE

accuracy

delayed response test

efficiency decrement

head movements

monkeysperseverative errors

premature responses

total responses

visual discrimination test

NOREPINEPHRINE (182)

blood pressure

catechol

8471 cerebroside sulfate

denervated hind limb

8480 iproniazid

PAIN (185)

(186)

VOL. 131

lipid soluble complex 8450 vagal effects 8481

methylphenidate 8499 PENICILLIN (189)

phentolamine blockade 8499 cell wall synthesis 8448

positive inotropic action 8499 E. coli 8448

S. aureus 8448

PENTYLENETETRAZOL (190)

OUABAIN (183) albino mice 8474

anti-adrenergic action 8477 anticonvulsants 8474

A-V refractory period 8477 CNS excitants 8474

inotropic action 8457 dopa influence 8474

papillary muscle 8457 dopamine influence 8474

OXYGEN CONSUMPTION (184) 5-NT influence 8474

reserpinized mice 8473 5-HTP influence 8474

tissue homogenates 8473 iproniazid pretreatment 8474

tissue slices 8473 isopropylhydrazine

DL-triiodothyronine 8473 pretreatment 8474

reserpine effect 8474

tonic extensor seizures 8474

albino rats 8465 PERIPHERAL RESISTANCE, VASCULAR

aspirin 8465 amphetamine (191)8499

behavioral technique 8465 8498

morphine 8465 8498

pentobarbital 8465 8498

salicylates 8465 8498

tolerance changes 8465

PAIN, CHRONIC

vasoconstriction 8499blood pressure 8501

dextromoramide 8501 femoral vascular bed 8499

dose response 8501 guanethidine intravenously 8498

experimental design 8501 intraarterial injections 8499

heart rate 8501 intravenous tyramine infusion 8498

hospital patients 8501 i.v. norepinephrine infusion 8498

morphine . 8501 methylphenidate 8499

placebo administration 8501 norepinephrine perfusion 8498

potency ratio 8501 norepinephrine-induced

pupil size 8501 vasoconstriction 8499

relief measurement 8501 perfusion pressure 8498

respiratory rate 8501 phentolamine blockade 8499

statistical analysis 8501 phentolamine perfusion 8498

PAPILLARY MUSCLES (187) reserpine pretreatment 8498

adrenocortical steroids 8457 serotonin perfusion 8498

inotropic effects 8457 sympathetic electrical

PARASYMPATHETIC NERVOUS SYSTEM stimulation 8498

ACh stimulatory response (188)8481 systemic pressure 8498

atropine blocking action 8481 tyramine perfusion 8498

bladder contractions 8481 vasoconstrictor responses 8498

blood pressure 8481 PERPHENAZINE (192)

isolated muscle preparations 8481 antiemetic activity 8466

nerve stimulation response 8481 fluphenazine comparison 8466

sensitivity threshold 8481 PHENALIDINE (193)

stomach contractions 8481 cyproheptadine comparison 8459

angiotensin perfusion

atropine

cholinergic receptors

denervated hindlimb

8499

epinephrine-induced

NOR-PHE

SUBJECT INDEX

S-16

8458

8458

8485

8485

8458

8458

8458

8458

8485

8458

8458

8485

flow 8485

8458

8458

8458

8458


hi stamine -induced

bronchospasm 8459


serotonin-induced edema 8459

PHENELZINE (194)

Evans blue dye accumulation 8504

experimental inflammation 8504

Beta-PHENETHYL HYDRAZINE

(PHENELZINE) (195)


PHENOBARBITAL (196)

Cd4 modification 8490

enzyme induction 8490

ethionine modification 8490


microsomal-stimulating agent 8490

PHENOBARBITAL-C14 (197)

brain levels 8493

respiratory acidosis 8493

respiratory alkalosis 8493

selected areas 8493

PHENOLSULFONPHTHALEIN (198)

butyric acid facilitation 8495

intestinal absorption 8495

intraluminal environment 8495

PHENOXYBENZAMINE (199)

cation exchanges 8471

Cd4 hepatotoxicity 8497

indirect stimulation 8471

muscle contractility 8471

protective action 8497

skeletal muscle in situ 8471

Beta-PHENYLISOPROPYLHYDRAZINE

(PIH) (200)


(204)

8471

8471

8471

8471

8471

8464

8464

8464

8453

8453

(205)

(206)

(207)

8471

(201)

(202)

(208)

8471

8454

8487

8487

8454

8471

8471

8491

8504

8504

8504

8504

8500

8500

8500

8458

8485

8458

(209)

1961

SUBJECT INDEX

PHE-POL

S -17

grouped mice

mortality

motor activity

PHOSPHATE-P32 INORGANIC

gentian violet

penicillin

S. aureus incorporation

PICROTOXINgrouped mice

mortality

motor activity

PILOCARPINE

anesthetized cats

Ca45 uptake

ganglionic receptors

8459 ganglionic stimulant action

hexamethonium pretreatment

K42 uptake

kidney

methadone

morphine

nicotine

pressor response

renal blood flow


spinal cats

submaxillary gland

submaxillary gland blood

TEA

TM 10

TMA

tyramine comparison

PIPEROXAN

cation exchanges

contraction amplitude

direct stimulation

indirect stimulation

rat phrenic-nerve diaphragm

in vitro

PIPRADOL

grouped mice

mortality

motor activity

PITUITARY HORMONES


methadone dispositiop.

PLASMA

adr�riergic blockade

contracting skeletal muscle

in situ

8480 disappearance rate

8464 estrogen treatment

8464 free amino acid levels

8464 nitrofurantoin levels

potassium levels

8448 sodium levels

8448 triamcinolone-H3 half-life

8448 PLASMA VOLUME

capillary permeability

8464 Evans blue space

8464 experimental inflammation

8464 rat tissues

(203) POLYPEPTIDES

bradykinin

chromatography

discrimination indices

POL-RES VOL. 131

electrophoresis 8500 methadone absorption 8453

kallidin 8500 serotonin-induced edema 8459

urine flow 8500

POTASSIUM (210)

adrenalectomy 8456 QUATERNARY ANMONIUN COMPOUNDS

desoxycorticosterone 8456 benzomethaniine (218)8494

renal excretion 8455 8495

renal tubular function 8456 experimental procedures 8494

serotonin 8455 intestinal absorption 8494

stop-flow analysis 8456 8495

tubular reabsorption

POTASSIUN’�2 (211)

8455 intraluminal environment 8495

loop-preparations � vivo 8494

kidney uptake 8485 QUINIDINE (219)

pilocarpine effect 8485 action potentials 8479

submaxillary gland uptake 8485 cardiac excitability 8479

PREDNISONE (212) conduction time 8479

inotropic action 8457 depolarization time 8479

mineralocorticoid activity 8457 effective refractory period 8479

papillary muscle 8457 isolated rabbit atria 8479

PROMETHAZINE (213) lactate ion 8479

cyproheptadine comparison 8459 osmolarity 8479

egg-white induced edema 8459 repolarization 8479

inhibitor activity 8459 resting potential 8479

serotonin pressor response 8459 sodium gradient 8479

serotonin-induced edema 8459 sodium lactate reversal 8479

PSYCHOLOGICAL TESTS (214) sodium salt reversal 8479

delayed response 8463 stimulation rate 8479

efficiency decrement 8463 sucrose reversal 8479

nitrous oxide:oxygen 8463

visual discrimination 8463

PTOSIS , PALPEBRAL (215) RECEPTORS , STRETCH (220)

CNS excitants 8474 muscle spindle discharge 8482

dopa influence 8474 ryanodine pretreatment 8482

dopamine influence 8474 succinylcholine effect 8482

5-HT influence 8474 REFRACTORY PERIOD (221)

5-HTP influence 8474 anti-adrenergic effect 8477

iproniazid pretreatment 8474 A-V transmission 8477

isopropyl hydrazine cardiac glycosides 8477

pretreatment 8474 RENAL FUNCTION (222)

reserpine induced 8474 electrolyte excretion 8455

PYRIDOXINE (216) glomerular filtration rate 8455

blood pressure responses 8492 renal plasma flow 8455

deficiency effects 8492 serotonin 8455

hydroxyphenylpyruvic acid tubular loads 8455

in vivo 8492 urine flow 8455

PYRILAMINE (217) R.ESERPINE (223)

cyproheptadine comparison 8459 albino mice 8472

egg-white induced edema 8459 8474

histamine-induced alkylating agents 8473

bronchospasm 8459 anticonvulsants 8474

inhibitor activity 8459 anti-tumor effect 8473

SUBJECT INDEX

5-18

8468

8468

8474

8473

84788478

8474

8474

8478

(225)

(226)

(227)

(228)

(229)

8461

8461

8502

8461

8502

8461

8482

8482

8482

8465

8465

8465

8465

8465

8493

8493

8493

8493

8452

8459

8459

8452

8459

8452

8452

8459

8452

8459

8459

8459

8452

8483

8456

84838483

8456

8483

8483

8483

8455

8456

8455

8456

(224)

8474

8478

8472

8473

84738473

8473

8473

8478

8473

8502

8502

8461

8461

8502

8461

8502

8502

8461

8502

8461

8461

8461

8502

8461

8461

1961SUBJECT INDEX

RES -SOD

S -19

body weight

caffeine tonic extensor

seizures


activity

circulating catecholamines

CNS excitants

food intake

graded dose-responses

heart-lung preparation

iproniazid influence

isopropylhydrazine influence

myocardial contractility

oxygen consumption

palpebral ptosispentylenetetrazol tonic

extensor seizures

beta-phenyli sopropylhydrazine

antagonismprotective effect

protein amino-acidincorporat ion

reserpine derivatives

seizure facilitation

sympathetic nerve stimulation

thiopental-induced gangrene

DL-triiodothyronine

combinat ion

tumor growth

tumor protein synthesis

tumor volume

tumor-bearing mice

ventricular function curves

water intake

RESPIRATION

action duration

action mechanism

amplitude

central vagal stimulation

chlorpromazine

CO2 tension

controlled alveolar pCO2

depressant effects

H-ion concentration

human subjects

levallorphan antagonism

meperidine effect

8502

midcollicular decerebration

minute volume

morphine effect

neuronal excitability

8473 rate 8461

85028474 reflex mechanisms

rhythm changes

simultaneous administration

stimulus threshold

tidal volume

vagotomized cats

RYA.NODINE

anesthetized cats

muscle spindle discharge

succinylchol me

8473

8474 SALICYLATE

albino rats

8474 behavior responses

central nervous system

8474 pain tolerance

8472 tolerated shock level

SALICYLIC ACID-C14

8473 brain levels

8473 respiratory acidosis


selected areas

SEROTONIN

c14 labeled


“ganglion-blocked” dog

5HIAA formation

local edema

MAO inhibitors

metabolism in vivo

pressor responses

radioactive metabolites

rat uterus

reference agents

spasmogenic effect

urinary metabolites

SODIUM

action mechanism

adrenal ec tomy

cocaine antagonism

cocaine concentration

desoxycorticosterone

ion concentration

nerve conduction block

neural function

renal excretion

renal tubular function

5 e rot onin

stop-flow analysis

(230)

8479

8479

8479

8497

8497

8497

8448

8448

heart rate

heart-lung preparation

myocardial contractility

peripheral anti-adrenergic

effect

postganglionic stimulation

8478


sympathetic discharge

SYMPATHETIC NERVOUS SYSTEM,

8481 GANGLION (239)

8481 ganglionic blocking agents

8481 histamine pressor response

8481 pilocarpine pressor response

sympathin release

SYMPATHETIC NERVOUS SYSTEM,

PERIPHERAL (240)

8458

8458

8458

8458

SOD-THE

tubular loads 8455 digitalis inhibitor activity 8477

tubular reabsorption 8455 digitoxin effect 8476

SODIUM LACTATE epinephrine infusion 8476

isolated rabbit atria functional state 8468

quinidine effect 8477

reversing action 8478

SPINAL CORD (231) 8478

C6 transection

CC14 hepatotoxicity 8477

protective action 8476

STAPHYLOCOCCUS AUREUS (232)cell wall synthesis 8478

penicillin 8497

STOMACH (233)

anesthetized dog

atropine inhibitor activity

contraction response

vagal stimulation

STRYCHNINE (234)

albino rats 8475

convulsant effects 8475

maturation influence 8475 blood pressure 8498

toxic effects 8475 guanethidine blocking action 8498

SUBMAXILLARY GLAND (235) vascular effectors 8498

blood flow 8485 SYMPATHIN (241)

Ca45 uptake 8485 adrenalectomy 8458

fractional distribution

K42 uptake

8485

8485

adrenergic postganglionic

terminals 8458

pilocarpine effect 8485 histamine-induced liberation 8458

SUCCINYLCHOLINE (236) methadone 8458

action potentials 8482 morphine 8458

anesthetized cats 8482 pilocarpine-induced

fusimotor stimulation 8482 liberation 8458

intrafusal fiber response 8482 TM-lO 8458

mammalian muscle spindles 8482 SYNPATHOMIMETIC ANINES (242)

muscle contracture 8482 1-epinephrine 8467

muscle stimulation 8482 isolated perfused rat heart 8467

ryanodine pretreatment 8482 myocardial phosphorylase a

spindle discharge frequency 8482 activity 8467

stretch receptors 8482 positive inotropic action 8467

SYMPATHETIC BLOCKADE,

POSTGANGLIONIC (237)

bretylium 8468 THENA.LIDINE (243)

cardiac phosphorylase cyproheptadine comparison 8459

activity 8468 egg-white induced edema 8459

SYMPATHETIC NERVOUS SYSTEM (238) histamine-induced

acetyldigitoxin effect 8476 bronchospasm 8459

auricular fibrillation 8477 inhibitor activity 8459

auricular flutter 8477 serotonin pressor response 8459

cardiac acceleration 8476 serotonin-induced edema 8459

cardiac phosphorylase TH.EOPHYLLINE (244)

activity 8468 aminotheophylline comparison 8486

CC14 hepatotoxicity 8497 diuretic effect 8486

SUBJECT INDEX

VOL. 131

5-20

THIOPENTAL (245)gangrene production

injection site

reserpine effect

subcutaneous injection

ulcer production

TISSUE (246)

Evans blue dye concentration

experimental inflammation

histamine inhibitors

histamine liberators

histamine pretreatment

plasma volumes

quantitative measurement

serotonin

serotonin inhibitors

serotonin liberators

TISSUE, TUMOR (247)

amino-acid incorporation

reserpine effect

starvation diet

tumor-bearing mice

TRANSMISSION, A-V (248)

anti-adrenergic effect

metabolism in vivo

TIJNGSTATE, SODIUM (255)blood methanol disappearance

liver homogenates

methanol metabolism in vitro

sodium molybdate


TYRAMINE (256)

histamine comparison

pilocarpine comparison

pressor response

rn-TYROSINE (257)

decarboxylationHCS blocking effect

pressor effect

rn-tyramine formation

8477 brain levels

8503injection 8503

8503

selected areas

URETHAN (260)CC14 modificationenzyme induction

ethionine modificationhexobarbital sleeping time

microsomal-stimulating agent

UTERUS (261)

estradiol effect

free amino acids

ovariectomized rats

cardiac glycosides 8477

functional refractory period 8477

TRANSMISSION, GANGLIONIC (249)

ACh stimulatory action 8480

monoamine oxidase inhibitors 8480

nictitating membrane response 8480

pentobarbitalized cats 8480

perfused cervical ganglion 8480

preganglionic stimulation 8480

TRANS -2-PHENYLCYCLOPROPYL-

AMINE (PCA) (250)


TRIA}�INOLONE-H3 (251)

blood concentration

plasma half-life

radioactivity excretion

tissue distribution

TRIFLUPROMAZINE (252)

antiemetic activity

fluphenazine comparison

TRIMEPRAZINE (253)

cyproheptadine compari son


inhibitor activity

serotonin pressor response

serotonin-induced edema

TRYPTAMINE (254)

IA�A formation

MAO inhibitors

E. coli incorporation

8466 penicillin

8466 VASOCONSTRICTORS

amphetamine

(262)

(263)

(264)

(265)

pharmacologic response

1961

SUBJECT INDEX

S -21

8472

8472

8472

8472

8472

8504

8504

8504

8504

8504

8504

8504

8504

8504

8504

8473

8473

8473

8473

8491

8491

8491

8491

8459

84598459

8459

8459

8452

8452

ULTRAVIOLET LIGHT

animal exposure

8 -methoxypsoralen

toxicity studies

UREA-C14

respiratory acidosis


taurine levels

weight changes

VALINE -C14

femoral vascular bed

methylphenidateVASOPRESSIN


XANTHINES

diuretic effect

THI-XAN

(258)

(259)

8452

8469

8469

8469

8469

8469

8458

8458

8458

84928492

8492

8492

8493

8493

8493

8493

8490

8490

84908490

8490

8487

8487

8487

8487

8487

8448

8448

8499

8499

8499

8453

8486

8486

84628491

8449

85018503

8471

8490

Inesi C 8467

1961AUTHOR INDEX

VOL. 131

A-i

Aceves J

8477

Adair E J

Adler M W

Albert J R

Alford D

Angell E A

Aprison N H

8476 Ferster C B

Florini J R

8470 Fouts J R

8463 Free S M Jr

8460 Freeman R G

8488 Friedman S M

8455 Fujimoto J M

8462

Baird G M

Barlow C F

Bauer R 0Beach V L

Blinks J RBohner B

Boudet R A

Bowen E H Jr

Boxill G CBrody T M

Brooks WBukovsky J

Burgison R M

Burke J C

Burn J H

Buyske D A

Buzard J A

Cafruny E J

Calvert D N

Campbell A D

Chen G

Clark W C

Coles F K

Condouris C A

Conklin J D

Cox A R

Craver B N

Daniel A I

Day M

Dreisbach R H

Drell W

Eldred E

Elison C

Elliott H W

Eubank L L

8473

8493

85018504

8478

8474

8488

8501

84608497

8455

84898486

8466

8472

8491

8454

8484

8497

8451

8474

8492

8451

8483

8454

8479

8466

8499

8450

8485

8492

8482

8453

8453

8451

Gertner S B

Goldberg M A

Green J P

Creenblatt E N

Griffin A C

Hakim R EHaugaard N

8468Hensala J C

Hess M E

8468

Holland R

Huf E C

}Iuffman W

Jarvik M E

Kalman S N

Kaneko Y

Kerby C F

Knox J N

Krantz J C Jr

Kukovetz W R

Laffan R J

Lambertsen C J

Laties V C

Leibman K C

Levine R R

8495 8496Little J N

Lombrozo N E

Longenhagen J B

Lovenberg W

Ludden C T

8480

8493

8450

8464

8503

8503

8467

8486

8467

8499

8451

8455

8463

8487

8498

8457

8503

8486

8467

8466

8502

8465

8488

8494

8455

8487

85028452

8459

8498

8472

8470

8496

8449

8469

8499

8476

8467

8456

8456

84828471

8459

8504

8473

84598448

8499

84578469

8458

O’Keefe E

Osterberg A C

Van Arman C C 8500

Yard A S

Zirkle C S 8496

1961AUTHOR INDEX

VOL. 131

A-2

McCubbin J W

McDougal D B Jr

McKennis H Jr

McLean R

McLuen E FMannering C J

Maxwell R A

Mendez C

8477

Mendez R

8477

Miller L N

Nathenson S G

Ngai S H

Page I H

Palmer J F

Papandrianos D P

Parks R E Jr

Paul N F

Peets E A

Pelikan E W

Plaa C L

Pogrund R S

Pradhan S N

Pylkko 0 0

Redfield B G

Robinson J D Jr

Ross C A

Roth J S

Roth L J

Schneider A F

Schneider F

Shanfeld J

8468

Shideman F E

Skulan T W

Smith C N

Sreter F A

Stavorski J N

Steinetz B C

Steward J D

8476 Stone C A

Strominger J L

8500 Sylwestrowicz H D

8448 Tanz R D

8461 Tephly T R

Trendelenburg U

8454

8464

8498

8484

8466

8469

8454

8491

8494

8490

8492

8473

8475

8452

84508459

8489

8493

8497

8499

Udenfriend S

Ursillo R C

Waud D R

Weatherby J H

Weikel J H Jr

Weinstock J

Weiss B

Weissbach H

Wendel H

Wenger H C

West T C

West W L

Williamson H E

Woodbury D N

8452

8481

8478

84708460

8496

8465

8452

8502

8459

8479

8473

8456

8475

8470

JANUARY

Entry

8448 1

8449 78450 12

8451 18

8452 26

8453 31

8454 38

8455 44

8456 498457 56

8458 65

8459 73

8460 85

8461 91

8462 100

8463 108

8464 115

8465 120

8466 130

Auxiliary Index-Part I

Index to Pages

VOLUME 131, 1961

FEBRUARY

Entry

8467 137

8468 1438469 147

8470 152

8471 158

8472 167

8473 171

8474 179

8475 185

8476 191

8477 199

8478 205

8479 212

8480 223

8481 231

8482 237

8483 243

8484 250

8485 257

8486 261

8487 265

MARCH

Entry

8488

8489

8490

8491

84928493

84948495

84968497

84988499

8500

8501

8502

8503

8504

271

275282287

294

308

319

328

334341

346

355

366

373

381

394

400

Al-i

1961 NOTICE VOL. 131

to Subscribers and Readers

Because of the comprehensive nature of the Journal index, the following

explanatory comment, with special reference to subject analysis, seems ap-

propriate at this time.

Subject Content: This is available to the reader through simple, coordin-

ate search of the Subject Index. Coincident display of pertinent headings

and subheadings, arranged alphabetically, assures the searcher that signif-

icant information will not be missed. The information thus acquired may

be divided into three categories:

First: The Number of Articles Cited on Each Subject.

Rapid survey of the entry numbers listed opposite the subheadings will

indicate the scope and variety of topic coverage. The subheadings describe

the subject content in unit terms, with separate access afforded for each

idea. For the convenience of direct page reference, AUXILIARY INDEX-PART I

presents a table of Index to Pages.

Second: The Number of Subjects Covered in Each Article.

The Subject Index admits topic headings according to the relative impor-

tance of the competing information in each article, and by careful selec-

tion, the duplication of subject headings is minimized, without sacrificing

essential flexibility. By the liberal use of such heading�, numbered ser-

ially in parenthesis, complete cross-reference is simple and productive,

free from the accumulation of cumbersome “see” and “see also” listings in

common use.

For the purpose of cross-reference the short index of alternative headings

represented in AUXILIARY INDEX-PART II is recommended. The appropriate head-

!.a& numbers are arranged below the underscored entry numbers, and can bequickly located by first consulting the parenthetic numbers in the Subject

Index.Third: The Associations of Ideas Related to the Subject of Search.

Ready comparison of ideas described under one heading with those listed

under the alternative headings will often lead to a fund of relevant facts.

In this manner, tracing ideas through the total system should open the way

to useful material that is beyond the limits of restricted fields of inquiry.

1961 Auxiliary Index-Part II VOL. 131

Index to Subject Headings

8448 8453 8458 8463 8469 8474 8480 8487 8493 8499

34 1 10 70 25 223 200 207 197 102

44 8 52 181 50 249 261 227 123

69 10 113 214 101 8475 250 259 166

87 13 133 107 15 8488 179

104 28 178 160 57 8481 3 8494 182116 38 203 8464 163 70 43 47 1 191

117 80 239 26 255 79 49 64 45 263

157 134 241 27 234 52 101 145

189 160 256 53 8470 175 218 8500

201 161 58 50 � 188 �! 51

232 206 8459 70 66 6 233 83 8495 52262 217 37 162 118 89 101 1 54

264 41 166 135 102 8482 155 32 94

� 48 200 153 119 172 158 45 149

2 � 52 202 160 128 220 160 68 171

23 1 73 205 238 225 111 209

27 115 74 8471 236 8490 145

74 160 81 � 11 �2�Z 63 198 8501

76 180 93 70 50 6 8483 100 218 29

84 207 97 185 67 33 75 108 86

101 113 226 77 88 174 132 8496 169

131 � 133 170 89 229 160 1 186

148 72 137 8466 176 119 196 121

154 98 156 36 199 123 8484 260 179

160 140 171 74 204 183 82 8502

150 193 99 207 221 92 8491 8497 19

� 210 213 112 238 95 14 9 29

5 222 217 192 8472 248 129 50 10 62

21 229 228 252 114 150 136 12 74

55 243 223 8478 159 160 63 158

71 � 253 � 245 78 207 101 173

133 10 101 126 8485 251 103 224

140 85 � 125 8473 223 59 154

144 151 20 242 18 238 150 8492 199

182 210 35 22 203 52 231 8503

229 109 8468 39 8479 211 90 238 46

�_4a 10 184 124 235 91 154160 � � 31 223 219 138 8498 165164 14 70 56 247 230 8486 139 52 258

80 152 101 24 160 65

85 158 113 8474 8480 52 216 120 8504127 169 123 35 5 96 257 191 30

� 143 224 130 40 122 244 240 60101 183 223 58 146 265 8493 110

146 187 237 70 147 4 8499 140

160 212 238 146 168 8487 7 27 142

167 8462 168 177 22 17 42 194

228 � 70 8469 190 179 105 61 52 208

254 9 141 16 215 195 106 70 65 246

AI-2

Documents

SUBJECT INDEX ABSORPTION (1) ACIDOSIS (7)jpet.aspetjournals.org/content/jpet/131/3/local/back-matter.pdfABSORPTION (1) ACIDOSIS (7) adrenocortical hormones 8453 central nervous system