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Summer Vacation Research Scholarship. Lulu Liang. The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury – Randomised Controlled Trial (POLAR-RCT). - PowerPoint PPT Presentation
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Summer Vacation Research Scholarship
Lulu Liang
ANZIC-RC
Traumatic Brain
Injuries
POLAR
POLAR BEAR
Renal Sub-study
EPO
ARISE Olivier’s Study
Flail Chest Study
Blood Transfusio
n
The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury –
Randomised Controlled Trial (POLAR-RCT)
To investigate whether prophylactic hypothermia has better neurological outcomes over standard management (normothermia) 6 months post TBI
BackgroundWhy is this being done?
Affects 1000 Australians every year Health issues:
o Disability and death Economical issues Societal issues Previous studies
o Lab and clinical trials show hypothermia to be neuroprotective
o Previous methodological limitationso First-of-its-kind in Australia
Method
512 Participan
ts
Normothermia
Hypothermia
Maintained at 37±5°C
Rapidly cooled to
33°C for 72 hours
Gradually rewarmed
End result: Neurological outcome at 6 months follow-up (GOSE)
Results/DiscussionWhat I observed over a 5 week period: 15 patients were followed Mortality and survival rates at ICU-discharge were
similar Challenges
o Hypothermia: bleeding, infection, logistics with timingo Normothermia: infection
Is hypothermia beneficial in TBI?
Conclusion
Cannot be drawn as study still in progress. However, the results may potentially change clinical practice on the current management of TBI in an ICU setting.
Reflections
Video