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Superconducting Organic and CNT FETs Based Biosensor/Transducer. DrEng Rostyslav Sklyar, Verchratskogo 15-1, Lviv 79010 Ukraine External transducer SQUID magnetometer • induction sensor Implantable transducer Renview bight amperometric biosensor Longitudinal section of an axon showing a current flow. a) an action potential; b) record of micro- electrode in neuron.

Superconducting Organic and CNT FETsBased Biosensor/Transducer

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Su

perc

on

du

ctin

g O

rgan

ic a

nd

CN

T F

ETs

Base

d B

iose

nso

r/Tra

nsd

uce

r.D

rEng

Ros

tysl

av S

klya

r, Ve

rchr

atsk

ogo

15-1

, Lvi

v 79

010

Ukr

aine

Exte

rnal

tran

sduc

er•

SQU

ID m

agne

tom

eter

• ind

uctio

n se

nsor

Impl

anta

ble

tran

sduc

er•

Ren

view

big

ht•

ampe

rom

etric

bio

sens

or

Lon

gitu

din

al s

ecti

on o

f an

axo

nsh

owin

g a

curr

ent

flow

.a)

an

actio

n po

tent

ial;

b) re

cord

of m

icro

-el

ectr

ode

in n

euro

n.

SuFE

TTr

as t

he

incl

usi

on o

f a

SuFE

T d

evic

e in

to t

he

ner

ve fib

re.

A-

imp

lan

tati

on

of

the w

hole

Su

FET

va

rian

t;

B-

tap

pin

g o

f B

S o

n t

he e

xte

rnal

Su

FE

T b

y im

pla

nta

ble

wir

e c

on

tact

s.

Equi

vale

nt

circ

uit

of

aSuFE

TTr

of v

ortica

l m

agnet

icfiel

d H

aro

und a

bio

chem

ical

med

ium

.

PC

×g D

S

SuFE

T

Cin

/2R

gate

Cin

/2V

GS

C0

Cry

osta

t

Gat

e

R

~E

0 L-

Shie

ld

Sour

ceDra

ine

JJ

JJ- i

ndic

ates

Jos

ephs

on ju

nctio

n.

H

Ner

ve fi

bre,

syn

apse

s of

neu

rons

,D

NA

spi

ral

i bio

in v

ivo

nerv

eim

pulse

mye

lin chan

nel gateVg

ionic

curre

nts

SFET ax

ons

(Bio

)Tele

met

ry

follo

wing

ext

erna

l uni

ts

Fi1

ASF

ETb

dbi

dd

ii

lbh

i

trans

mit-

ting

unit

rece

iving

unit

visua

lan

d m un

SuFE

g DS

SuFE

T

C in/2

R gate

C in/2

V GS

Cryo

stat

Gate

- +

°

Sour

ceDrain

e

JJ

A

V out

NI

B

i bio ‘s

Super

conduct

ing O

rgan

ic a

nd C

NT

FETs

Bas

edBio

senso

r/Tr

ansd

uce

r- D

esi

gn

of

the C

ircu

it

()

20)

/(

11

2)

(I

ieQ

CQV

bio

GT

GGS

−−

+=

ωh(E

N)2 =4

kTSu

FET γ n

oise

/gdn

a

nd

gdn

=I0/V

C

Super

conduct

ing O

rgan

ic a

nd C

NT

FETs

Bas

ed B

iose

nso

r/Tr

ansd

uce

r.

An

org

an

ic S

uFET d

evic

ean

d its

ele

ctro

des.

Sch

em

ati

c o

f th

e e

lect

roly

teg

ate

measu

rem

en

t.

OFET o

f o

rgan

ic s

ing

le c

ryst

als

wit

hb

ott

om

-con

tact

co

nfi

gu

rati

on

.A-

the

schem

atic

stru

cture

of th

e fa

bric

ate

d O

FET;

B-

tran

sfer

char

acte

rist

ics

of t

he

single

cry

stal

FET

devi

ce a

t a

sourc

e-dr

ain

vol

tage

Vd o

f -3

0 V

.

Uou

t i bio

AB

Vo

ut

AB

i bio

Vg,

V

Q, n

S

01

400

200

t

- -

I

t

i bio

Vou

tV

sup=

cons

t

A 4

by 4

cro

ssed

NW

-FET a

rray

Op

era

tio

nal p

att

ern

of

ap

ara

llel S

uFETTr.

Supe

rcon

duct

ing

Org

anic

and

CN

T FE

Ts B

ased

Bio

sens

or/T

rans

duce

r.

1. S

klya

r R.,

A Su

FET

Base

d Ei

ther

Impl

anta

ble

or N

on-In

vasi

ve(B

io)T

rans

duce

r of N

erve

Impu

lses

",13

th In

tern

atio

nal S

ympo

sium

on

Mea

sure

men

t and

Con

trol i

n R

obot

ics

-IS

MC

R'0

3, M

adrid

, Spa

in (2

003)

, pp.

121-

126;

2. S

klya

r R.,

Supe

rcon

duct

ing

Org

anic

and

CN

T FE

Ts a

s a

Bioc

hem

ical

Tran

sduc

er, I

SMC

R 2

004:

14t

hIn

tern

atio

nal S

ympo

sium

on

Mea

sure

men

t and

Con

trol i

n R

obot

ics,

16-1

8 Se

ptem

ber 2

004

- NAS

AJo

hnso

n Sp

ace

Cen

ter,

Hou

ston

, Tex

as,

sect

ion

24 (t

he s

econ

d), (

13 p

ages

);3.

Skl

yar.R

., A

supe

rcon

duct

ing

bios

enso

rof

the

bios

igna

ls, E

uros

enso

rs X

VIII,

Sept

embe

r 13-

15, 2

004,

Rom

a; It

aly,

Dig

est B

ook

(4 p

ages

).

Auth

or c

onta

ct in

form

atio

n:D

rEng

. Ros

tysl

av S

klya

rVe

rchr

atsk

ogo

st. 1

5-1,

Lvi

v 79

010

Ukr

aine

.Te

l. +3

8 09

7 33

6549

5Fa

x:+3

8 03

22 7

6961

3;sk

lyar

@cb

-igph

.lviv

.ua

SE

RIA

LP

AR

ALLE

L

MODE

MEDIUM

ex

tern

al

imp

lan

tab

.ex

tern

al

imp

lan

tab

.

NI

i bio=1

co-

ntro

l or

sens

. im

p.

i bio=i

bio(f 1

)+

i bio(f 2

)+…

+ibio

(f N)

dibio

/dt,

dibio

/dx

Σi b

io=1

net

-

wor

k or

1 fib

re

Mole

cule

s

BSs→

bio

and

chem

.

mol

ec.

varia

tion

of

BSs→

con

-

cent

r. of

m.

ΣB

Ss=1

type

of

mol

ec.

ΣB

Ss= Σ

bio

and

chem

.

mol

ec.

DN

A

prop

ag. o

f

BS

alon

g

DN

A’s

spira

ls

deco

ding

the

BSs

of

nucl

eote

d

reco

gniti

on

spac

e an

d

leng

th d

y-

nam

ic o

n

DNA’

s sp.

4 nu

cleo

-

teds

→ 4

outp

uts

Table:

Dep

ende

nce

of th

e re

ceiv

ed B

S pa

ram

eter

son

the

mod

e of

SuF

ETTr

’s fu

nctio

ning

.