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Supplemental Table and Figure Legends Table S1. Clinical ... ... 23 calcium-binding mitochondrial carrier protein Aralar2 isoform 2 74175.1 7657581 24 probable saccharopine dehydrogenase

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  • Supplemental Table and Figure Legends

    Table S1. Clinical characteristics and hepatic enzyme activities of human participants.

    (-) NAFLD (N=9) (+) NAFLD (N=12)

    MALE (N=7)

    FEMALE

    (N=2)

    MALE

    (N=5)

    FEMALE

    (N=7)

    Age (years) 62±7.4 44±0 67±8.6 62±9.3

    BMI (kg/m 2 ) 22.2±1.8 22.0±2.1 26.7±5.5

    * 24.7±1.4

    ##

    Comorbidities

    Hypertension (%) 42.9 50 60 42.9

    Diabetes mellitus (%) 14.3 0 0 28.6

    Dyslipidemia (%) 0 0 40 71.4

    Liver biochemistries

    ALT(U/L) 17.7±8.1 9±0 18.6±13.3 18.7±10.1

    AST(U/L) 20.3±8.2 11±2.8 22.2±6.8 18.3±3.8

    Values expressed are mean ±SD.

    BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase.

    *P

  • 15 plectin isoform 1e 513705.9 41322908

    16 methyltransferase-like protein 7A precursor 28318.9 89145417

    17 UTP--glucose-1-phosphate uridylyltransferase isoform a 56939.9 48255966

    18 apolipoprotein B-100 precursor 515528.6 105990532

    19 fatty acid synthase 273423.2 41872631

    20 ATP synthase subunit beta, mitochondrial precursor 56559.5 32189394

    21 perilipin-2 48075.1 34577059

    22 peroxisomal bifunctional enzyme isoform 2 69153.5 261878539

    23 calcium-binding mitochondrial carrier protein Aralar2 isoform 2 74175.1 7657581

    24 probable saccharopine dehydrogenase 47151.1 55770836

    25 long-chain-fatty-acid--CoA ligase 5 isoform a 82262.5 42794756

    26 estradiol 17-beta-dehydrogenase 11 32935.6 142976729

    27 carbamoyl-phosphate synthase [ammonia], mitochondrial isoform c 116037.4 170295797

    28 annexin A6 isoform 1 75872.8 71773329

    29 tubulin alpha-1A chain 50135.3 17986283

    30 trifunctional enzyme subunit alpha, mitochondrial precursor 82999.1 20127408

    31 programmed cell death 6-interacting protein isoform 1 96022.6 22027538

    32 17-beta-hydroxysteroid dehydrogenase type 6 35965.5 19743808

    33 ATP synthase subunit alpha, mitochondrial precursor 59750.3 4757810

    34 bile acyl-CoA synthetase precursor 75384.7 13325057

    35 cytochrome P450 2E1 precursor 56848.6 10834998

    36 formimidoyltransferase-cyclodeaminase 58926.2 11140815

    37 NADH-cytochrome b5 reductase 3 isoform 2 31628.5 193794826

    38 very long-chain acyl-CoA synthetase isoform 1 70311.8 227499619

    39 D-3-phosphoglycerate dehydrogenase 56650.2 23308577

    40 microsomal glutathione S-transferase 1 17598.6 9945306

    41 prelamin-A/C isoform 1 precursor 74139.0 27436946

    42 glutamate dehydrogenase 2, mitochondrial precursor 61433.6 31377775

    43 acetyl-CoA carboxylase 2 precursor 276537.6 134142062

    44 UDP-glucuronosyltransferase 2B4 precursor 60512.1 149944509

    45 dehydrogenase/reductase SDR family member 1 33908.8 209862901

    46 D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 38156.9 44680133

    47 UDP-glucuronosyltransferase 2B7 precursor 60720.3 190194389

    48 villin-1 92694.4 194394237

    49 17-beta-hydroxysteroid dehydrogenase 13 isoform A 33655.2 210032110

    50 non-specific lipid-transfer protein isoform 1 proprotein 58993.3 19923233

    51 cytochrome P450 2C9 precursor 55627.6 13699818

    52 eukaryotic initiation factor 4A-II 46402.0 83700235

    53 cytochrome P450 2C19 precursor 55944.8 4503219

    54 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

    precursor 68569.0 4506675

    55 protein transport protein Sec23A 86160.3 38202214

    56 perilipin-3 isoform 1 47074.7 255958282

    57 perilipin-1 55990.0 223718203

    58 aldehyde dehydrogenase family 8 member A1 isoform 3 48035.6 301500698

    59 liver carboxylesterase 1 isoform c precursor 62392.5 68508957

    60 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 72691.1 156416003

  • 61 tubulin beta chain 49670.5 29788785

    62 elongation factor 2 95337.6 4503483

    63 talin-1 269764.4 223029410

    64 78 kDa glucose-regulated protein precursor 72332.5 16507237

    65 serum paraoxonase/lactonase 3 39607.2 29788996

    66 cytochrome P450 2D6 isoform 1 55730.1 40805836

    67 amine oxidase [flavin-containing] B 58762.6 38202207

    68 calnexin precursor 67567.8 10716563

    69 vimentin 53651.3 62414289

    70 corticosteroid 11-beta-dehydrogenase isozyme 1 32400.8 5031765

    71 SEC14-like protein 2 isoform 1 46145.0 7110715

    72 histone H4 11367.3 4504301

    73 NADPH--cytochrome P450 reductase 77047.7 127139033

    74 synaptic vesicle membrane protein VAT-1 homolog 41920.0 18379349

    75 coatomer subunit alpha isoform 2 138344.7 148536853

    76 lanosterol synthase isoform 2 82198.1 224177556

    77 ADP/ATP translocase 2 32852.0 156071459

    78 cullin-associated NEDD8-dissociated protein 1 136374.7 21361794

    79 cytochrome P450 3A5 isoform 1 57108.3 4503231

    80 actin, gamma-enteric smooth muscle isoform 1 precursor 41876.7 4501889

    81 ras-related protein Rab-7a 23489.6 34147513

    82 voltage-dependent anion-selective channel protein 3 isoform 2 30789.6 208879465

    83 perilipin-4 134430.4 122937195

    84 endoplasmin precursor 92468.2 4507677

    85 alcohol dehydrogenase 1B 39835.3 34577061

    86 protein ERGIC-53 precursor 57548.6 5031873

    87 actin, cytoplasmic 1 41736.5 4501885

    88 bile salt sulfotransferase 33779.6 29540545

    89 sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating 41900.0 8393516

    90 myosin-Ib isoform 2 124949.7 44889481

    91 aldehyde dehydrogenase, mitochondrial isoform 1 precursor 56380.9 25777732

    92 membrane-associated progesterone receptor component 1 21671.0 5729875

    93 AP-2 complex subunit alpha-1 isoform 2 105360.8 19913416

    94 C-1-tetrahydrofolate synthase, cytoplasmic 101530.5 222136639

    95 cathepsin D preproprotein 44552.0 4503143

    96 hemoglobin subunit beta 15998.3 4504349

    97 myosin-10 228996.6 41406064

    98 AP-2 complex subunit beta isoform b 104551.9 4557469

    99 desmoplakin isoform I 331771.4 58530840

    100 hemoglobin subunit delta 16055.4 4504351

    101 cytochrome b5 isoform 1 15330.0 41281768

    102 ras-related protein Rab-14 23896.8 19923483

    103 60S ribosomal protein L4 47697.0 16579885

    104 hemoglobin subunit alpha 15257.4 4504345

    105 serum paraoxonase/arylesterase 1 precursor 39731.0 19923106

    106 fatty aldehyde dehydrogenase isoform 1 57669.1 73466520

    107 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase 58068.1 166362724

    108 cytochrome P450 3A7 57525.2 262290932

  • 109 trifunctional enzyme subunit beta, mitochondrial precursor 51294.1 4504327

    110 apoptosis-inducing factor 1, mitochondrial isoform 2 precursor 66294.3 22202629

    111 delta(24)-sterol reductase precursor 60100.9 13375618

    112 annexin A4 36084.8 4502105

    113 coatomer subunit beta 107141.5 7705369

    114 cytochrome P450 2C18 isoform 1 precursor 55710.4 13699816

    115 tricarboxylate transport protein, mitochondrial precursor 34012.4 21389315

    116 histone H2B type 1-C/E/F/G/I 13906.0 4504271

    117 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform 3 67523.9 316983158

    118 protein diaphanous homolog 1 isoform 1 141346.4 119395758

    119 protein transport protein Sec24A isoform 1 119748.6 116174780

    120 cytochrome P450 4F11 precursor 60145.5 193083178

    121 coatomer subunit gamma 97717.7 11559929

    122 carbamoyl-phosphate synthase [ammonia], mitochondrial isoform a precursor 165648.8 169790915

    123 very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 2

    precursor 68058.1 76496475

    124 calcium-binding mitochondrial carrier protein Aralar1 74761.4 21361103

    125 amine oxidase [flavin-containing] A 59681.3 4557735

    126 peroxisomal multifunctional enzyme type 2 isoform 2 79685.9 4504505

    127 fructose-bisphosphate aldolase B 39472.8 40354205

    128 protein disulfide-isomerase precursor 57115.9 20070125

    129 dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 1 60220.2 221316672

    130 estradiol 17-beta-dehydrogenase 2 42784.9 4504503

    131 nicotinamide N-methyltransferase 29573.8 5453790

    132 UDP-glucuronosyltransferase 1-7 precursor 59818.5 41282213

    133 mitochondrial carrier homolog 2 33330.7 7657347

    134 surfeit locus protein 4 30393.8 19557691

    135 epoxide hydrolase 2 62615.4 27597073

    136 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

    isoform 1 precursor 69283.5 35493916

    137 heat shock protein HSP 90-alpha isoform 1 98160.4 153792590

    138 heat shock protein HSP 90-beta 83263.6 20149594

    139 glutamate dehydrogenase 1, mitochondrial precursor 61397.5 4885281

    140 retinol dehydrogenase 10 38087.3 25282469

    141 prohibitin-2 isoform 1 33296.1 221307584

    142 NAD(P) transhydrogenase, mitochondrial precursor 113894.8 122939155

    143 oxysterol-binding protein 1 89420.0 4505531

    144 vesicle-trafficking protein SEC22b precursor 24593.2 94429050

    145 cytochrome P450 3A4 isoform 2 57255.8 322302351

    146 catenin alpha-1 100070.6 55770844

    147 signal transducer and activa

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