Upload
others
View
10
Download
0
Embed Size (px)
Citation preview
1
Sustainable proteins for muscle maintenance
Prof. L.J.C. van Loon
Maastricht University Medical Centre+Maastricht, the Netherlands
Maastricht, May 16, 2019
Fractional muscle protein synthesis
1-2 % per day
(0.04 – 0.14 %.h-1)
Muscle reconditioning
Lance Armstrong Jay Cutler
Muscle deconditioning
- immobilisation
- sarcopenia
- cancer cachexia
- COPD
- type 2 diabetes
- cardiovascular disease
2
Muscle maintenance Main anabolic stimuli
Nutrition is an anabolic stimulus Amino acids
Amino acids stimulate protein synthesisPost-prandial muscle protein synthesis
� protein digestion
� amino acid absorption
� plasma amino acid availability
� hormonal response
� postprandial perfusion
� muscle protein signaling proteins
� myofibrillar protein synthesis
3
Research methods Stable isotope tracers
Post-prandial protein synthesis
Groen et al., PLOS one, 2015
Post-prandial protein synthesis
Groen et al., PLOS one, 2015
Post-prandial protein synthesis
- amount of protein
- source of protein
- macronutrients
- timing
- food preparation
- body position
Source of protein
4
Milk and Beef
Burd et al., Am J Clin Nutr, 2015
Plant based proteins
van Vliet et al., J Nutr, 2015
Plant based proteins
van Vliet et al., J Nutr, 2015
Muscle gain on plant based protein consumption
Soy
Tang et al., J Appl Physiol, 2009Yang et al., Nutr Metab, 2012
Wheat
Gorissen et al., J Nutr, 2016
5
Plant derived proteins
� Nitrogen content
� Essential amino acid content
� Leucine
� Methionine
� Lysine
Essential amino acid content
Gorissen et al., Amino Acids, 2019
Leucine content
Gorissen et al., Amino Acids, 2019
Wheat
Gorissen et al., J Nutr, 2016
Plant and animal derived protein sources
Gorissen et al., J. Nutr, 2016
Dose response effect
6
Plant and animal derived protein sources
Gorissen et al., Amino Acids, 2019
Anabolic properties of plant based proteins
Alternative protein sources
Churchward-Venne et al., unpublished
Insect proteins
Churchward-Venne et al., Nutrition Reviews, in Press
Blattodea (5
)
Coleoptera (65)
Diptera (15)
Hemiptera (27)
Hymenoptera (4
6)
Isoptera (1
6)
Lepidoptera (64)
Odonata (2)
Orthoptera (7
5)
Beef (edible fle
sh)
Egg (hen, w
hole)
Milk (c
ow, paste
urized)
Soybean (s
eed)0
20
40
60
80
100
Aver
age p
rote
in co
nten
t [%
](b
ased
on
dry m
atte
r)
Meals Conclusions
Protein ingestion stimulates muscle protein synthesis rates
Differences in anabolic properties of protein sources
Anabolic properties of amino acid and protein mixtures
7
Collaborators and sponsors
M3 research unit
www.m3-research.nl
https://youtu.be/mCRzi1tObe0