Synapse 2011 (Volume V)

8/11/2019 Synapse 2011 (Volume V)

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Synapse"#$"Cornell


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Editor-in-Chief

Chong Guo 13

Undergraduate Peer EditorDaniel Acker 13

Jeanie Gribben 15Shayra Kamal 14

Alexandra Mattei 14Brian Morris 14

Tracy Netemeyer 14Samantha Olyha 14

Camille Shaw 14

Ryan Woolley 14

Design Editors

Louis Hopkins 14Trianna Lutchman 14

Lindsay Rappa 14

StaffWriters

Daniel Acker 13Emily Acton 13Peter Cohn 14Daniel Lee 14

Brian Morris 14Ethan Romano 14

Graduate Peer Editors

Loren LawHsien-Wei Meng

Spencer ParkShane Peace

Jade Wu

Managing Editor

Yoshiko Toyoda 14Jonathan Lin 14

FacultyAdvisor

Bruce Johnson

Volume 52011

e publication of this journal was made possible with funding from the Cornell UniversityStudent Assembly Finance Commission (SAFC). Views expressed in this publication may not

necessarily reflect those of the SAFC or Cornell University.

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synapse


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Dear Readers of Synapse,

I have recently encountered a book written by John A. Adam on mathematics in nature. In the introduction to thechapter on fractals, the author wrote something to the effect of caution, do not proceed if you wish to preserveyour childhood perception of clouds, you will never see them quite the same way again at the end of this chapter.

In a sense, this facetious (or maybe completely serious) statement captures well what neurobiologists had accom-plished in advancing our scientific understanding of the nervous system. From the epoch-setting doctrinal debatebetween Golgi and Remon y Cajal to the ingenious formulation of the Hodgkin-Huxley model, neuroscience hadindeed come a long way in dispelling many of our ancient dogmas about how the mind works. While it is reas-suring to know that we do not see via tentacle-like threads originating from the pupils as Greek philosophers oncebelieved or that hydraulic affects of the ventricular system formed the basis of all cognitive functions, neuroscienceas it stands today is still an on-going endeavor, one which involves researchers, clinicians and educators alike. Tothat end, Synapseexists as a window for students to witness this vibrant enterprise and to share their own worksand ideas via an open platform with the rest of the Cornell community.

In this issue of Synapse, we will explore some interesting topics such as the relationship between mirror neuronsand social behaviors, the efficacy of Omega 3 supplements, the growth of new neurons in adult brain and neu-rological diseases such as epilepsy, migraine, and Parkinsons. We strived to find a good balance between basicscience and translational research in our editing process and we hope that this final selection may interest as widean audience as possible. Having said that, as much as those of us here at Synapse would like to share with you ourpassions and curiosities about the brain, there is a limit to what a group of twenty or so undergraduate studentscan modestly accomplish with a 40 page publication. We wish that we could caution our readers with the boldnessof the aforementioned author that a reading of Synapse shall forever shatter your existing belief about clouds or,failing to do that, how you can perceive them at all. Nevertheless, we hope that you may walk away with a fewamusing tidbits about the brain, some nerdy conversation starters that may or may not work with that girl fromBIONB 2220 and ,if you are lucky, finally discovering what you do or do not want to do with the rest of your life.

e familiar readers of Synapsewill note some key changes in the publications structure. Two entirely new sec-tions have been added to the magazine, namely, the Featured Articles section and Neuro-in-the-News. While therigorousness with whichSynapse selects and publishes literature review and original research from Cornell under-graduate has been our biggest strength since the very inception of this journal, we wish to engage a wider audienceas well as to provide opportunities for students to write about neuroscience in a more open and expressive formatIn an effort to diversify our publication in terms of its style and content, we have created a brand new publicationwhich we are very excited to share with you.

Last but not the least, I want to extend my sincerest appreciation to our staffwriters, undergraduate/graduate edi-tors and the layout designers for all the work they have put into this issue of Synapse. I am very grateful also forhaving the opportunity to work with our two amazing managing editors Yoshiko Toyoda and Jonathan Lin. epublication process wouldnt have gone nearly as smoothly without their help.

Sincerely,

Chong GuoBiometry and Statistic 13


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iii

Progeria: Were Not All Dying Slowly . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 by Daniel AckerLight Driven Memory Recall. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 by Peter Wang

Creativity in the Brain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 by Jegath Athinlingame Effect of Methamphetamine on Memory in Snails . . . . . . . . . . . . . . . . . . . . . . 4 by Peter CohnI am My Connectome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 by Chong GuoSingle Cell Endoscope Opens Door to NanoscaleInteraction With Neurons. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 by Daniel AckerStimulation of Entorhinal Cortex Improves Memory in Epileptic Patients. . 6

by Emily ActonLove Bug or Love Drug?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 by Jade Wu

Anti-Epileptic Drugs and Seizure Severity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 by Kaitlin HardyCloning and Characterization of slo Family Potassium Channel Iso-forms in Lobster Nervous System. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 by Vinay Patel

Hippocampal Neurogenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 by Rachel BavleyOmega-3 or Omega-6? Breastmilk or Formula?. . . . . . . . . . . . . . . . . . . . . . . 31 by Jonathan Lin and Yoshiko Toyodaere is More to Parkinsons Disease than Motor Dysfunctions. . . . . . . . . . 38 by Diana HongMigraine Prevention: Neuromodulation for the Hyperexcitable Brain. . . . 42 by Bryanna Gulotta


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Specialanks To:

Department of Neurobiologyand Behavior

Student Assemble FinanceCommission

Documents

Synapse 2011 (Volume V)