2006

Other bioactive productsU 1300 Synthesis and in vitro Pharmacological Studies of New C(2) Modified Salvinorin

A Analogues. — Several derivatives of salvinorin A (I) are prepared and screened for their selectivity and affinity for κ-opioid receptor. Compound (V) is shown to be a full κ-agonist which is 7 times more potent than (I). — (COHEN*, B.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 16, 3744-3747; Mol. Pharmacol. Lab., McLean Hosp., Harvard Med. Sch., Belmont, MA 02478, USA; Eng.) — M. Bohle

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