T.A.Ban H.Hippius (Eds.)

Thirty Years CINP A Brief History of the Collegium Internationale N euro-Psychopharmacologicum

With Contributions by

O.H.Arnold. T.A. Ban, R.Belmaker, N.Bohacek, Z.Boszormenyi, P.B.Bradley, W.E. Bunney, G.D.Burrows,A. Carlsson, A. Coppen, P. Deniker, II. C.B. Denver, J. Elkes, J. R. De La Fuente, P. Grof, H.Hclmehen, H.Hippius, L. E. Hollister, P.Janssen, P.Kielholz, H. E. Lehmann, J. Levine, O. Lingj aerde, J . J . Lopez-Ibor, J.Mendlewiez,A.O.Odejide, P.Piehot, R.Racagni, C.Raduoco­Thomas, M. Sandler, G. Sed vall, F. G. Valdecasas, J. Vetulani, Z. Votava, J. R. Wittenborn, I. Yamashita

Springer-Verlag Berlin Heidelberg New York London Paris Tokyo

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ThomasA. Ban, M.D. Room 242, Medical Arts Building 1211 21st Avenue South Nashville, Tennessee 37212, USA

Professor Dr. Hanns Hippius Director of the Psychiatric Clinic of the Ludwig-Maximilians-University Nussbaumstr. 7, D-8000 Munich 2, FRO

ISBN-13:978-3-540-50117-6 e-ISBN-13 :978-3-642-73956-9 DOl: 10.1007/978-3-642-73956-9

This work is subject to copyright. All rights are reserved, whether the whole or part ofthe material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplica­tion of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9,1965, in its version of June 24,1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.

© Springer-Verlag Berlin Heidelberg 1988 Softcover reprint of the hardcover 1st edition 1988

The use of registered names. trademarks, etc. in the publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

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2125/3145-543210 Printed on acid-free paper

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In memoriam

Ole J. Rafaelsen t President CINP 1984 - 1986

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Dedicated to

P. H. Hoch t President CINP 1960-1962

H. Hoff t President CINP

1962 -1964

J. Delay t President CINP 1964 - 1966

E. Jacobsen t President CINP

1970-1972

E. Rothlin t President CINP 1957 - 1960

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The name of the Association is the Collegium Internationale Neuro­Psychopharmacologicum (hereinafter referred to as CINP). The CINP was founded at the 2nd World Congress of Psychiatry, Zurich, Switzerland, September 2,1957.

The object of the Association shall be to establish an organization whose members shall meet from time to time to consider and discuss matters relat­ed to neuropsychopharmacology and who through this organization shall encourage and promote international scientific study, teaching and ap­plication of neuropsychopharmacology.

The CINP shall also provide consultation and advice for the better evalua­tion of the biochemistry, pharmacology, safety and therapeutic efficacy of neuropsychiatric drugs and may act as an advisory body to educational institutions, governmental agencies, and such other organizations and bodies as determined by the Council.

CINP Constitution, Articles I and II

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Preface

The development of modern psychopharmacology was triggered by two major discoveries: the psychomimetic effects of lysergic acid diethylamide (LSD-25) in 1943 and the therapeutic effects of chlorpromazine in 1952. In his opening address to the 1st CINP Congress in Rome, Rothlin pointed out that these discoveries gave "a great impetus for any kind of scientific approach to brain research" and had "revolutionary consequences in the treatment of psychotic patients". The incentive they provided "was not limited to theoretical and practical medical sciences but caused an even greater stimulus to the imagination of chemists, leading to the production of new compounds with a speed that neither pharmacological, biochemical nor clinical investigations could equitably follow."

The possibility to induce psychopathology by the administration of pharmacological agents and to control naturally occurring psychopathol­ogy by drugs opened unforeseen possibilities for brain research and a new era in psychiatry. In psychiatry, the new psychotropic drugs with their increasingly better defined behavioral, neurophysiological and biochemi­cal actions have provided a new means for therapeutically influencing and systematically studying psychopathological conditions, whereas in the basic sciences, neuropharmacological research, directed to reveal the action mechanism of new drugs, brought about unprecedented progress in the identification of the morphological substrate of different brain func­tions. It also set the stage for the exploration of possible correlations between behavioral, including psychopathological, and neurochemical events. An essential prerequisite for such development was an organization which could provide a forum for the exchange of information and thereby facilitate communication among the different disciplines involved.

The need for an international collegium in neuropsychopharmacology was first expressed during a Symposium on Psychotropic Drugs, organized by Professor Trabucchi in Milan in the spring of 1957. Some months later, in September 1957, the formal inauguration of the Collegium took place during

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the Second International Congress of Psychiatry in Zurich. The 1st Congress of CINP was held one year later in Rome.

Since the 1st CINP Congress in 1958, thirty years have passed, and we can proudly state that CINP has remained faithful to its original mandate. The 15 CINP Congresses held during this period have provided a forum for clinicians and researchers from the various fields of neuropsychopharma­cology to meet and discuss their observations and findings. The program of these 15 Congresses reflects 30 years of progress in the field, and partici­pation in these Congresses provides a true picture of the increasing inter­est and involvement in neuropsychopharmacology around the world.

The Editors

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Table of Contents

History of CINP: From Rome to Munich

Introduction

The 1st Congress - Rome 1958 C. RADouco-THOMAS _............................. 5

The 2nd Congress - Basle 1960 H. C. B. DENBER ................................. 10

The 3rd Congress - Munich 1962 O. H. ARNOLD .. , ................................ 12

The 4th Congress - Birmingham 1964 P. B. BRADLEY ................................... 14

The 5th Congress - Washington 1966 J. ELKES ....................................... 17

The 6th Congress - Tarragona 1968 F. G. V ALDECASAS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20

The 7th Congress - Prague 1970 H. E. LEHMANN .................................. 23

The 8th Congress- Copenhagen 1972 T. A. BAN ...................................... 28

The 9th Congress - Paris 1974 H. HIPPlUS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

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The 10th Congress - Quebec 1976 P. DENIKER ..................................... 34

The 11 th Congress - Vienna 1978 L. E. HOLLISTER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37

The 12th Congress - Gothenburg 1980 A. CARLSSON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

The 13th Congress - Jerusalem 1982 P. JANSSEN ...................................... 44

The 14th Congress - Florence 1984 P. KIELHOLZ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49

The 15th Congress - San Juan 1986 J. R. WITTENBORN ................................. 51

The 16th Congress - Munich 1988 W. E. BUNNEY, Jr. .................................. 56.

Towards the 17th Congress - Kyoto 1990 A. COPPEN ...................................... 58

CINPToday

Introduction

Africa A. O. ODEJIDE ................................... 64

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Americas - Canada P. GROF ....... .

Americas - Latin Americas J. R. DE LA FUENTE ....

Americas - United States J. LEVINE ........... .

Asia - Far East 1. Y AMASHlTA

Asia - Israel R. H. BELMAKER

Australia G. BURROWS

Europe - Benelux Countries J. MENDLEWICZ ..... .

Europe - Czechoslovakia Z.VmAvA ......... .

Europe - Denmark, Finland and Norway O. LiNGJAERDE ............... .

Europe - France

70

72

74

77

80

85

91

96

99

P. PICHOT ..................................... 104

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Europe - German-Speaking Countries H. HELMCHEN .................................. 108

Europe - Hungary, Romania and Turkey Z. BOSZORMENYT ................................ 115

Europe - Italy G. RACAGNI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 118

Europe - Poland J. VETULANI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 121

Europe - Portugal and Spain J. J. LOPEZ-IBOR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 124

Europe - Sweden G. SEDVALL .................................... 126

Europe - United Kingdom M. SANDLER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 130

Europe - Yugoslavia N. BOHACEK .............................. 133

Concluding Remarks .............................. 137

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Founding Members (Zurich, 2nd September 1957)

O.H.Amold WIEN, Austria

H. Baruk ST. MAURICE, France

Joh. Booij AMSTERDAM, Netherlands

D. Bovet SASSARI, Italy

P. B. Bradley BIRMINGHAM, Great Britain

H. Brill NEW YORK, U.S.A.

B. B. Brodie BETHESDA Md., U.S.A.

D. E. Cameron ALBANyN. Y., U.S.A.

J. Delay PARIS, France

H. Delgado LIMA, Peru

H. C. B. Denber NEW YORK, U.S.A.

P. Deniker PARIS, France

A. Faurbye ROSKILDE, Denmark

F. Fliigel ERLANGEN, Germany

M. Gozzano ROME, Italy

H. Hippius BERLIN, Germany

H. Hoff VIENNA, Austria

A. Hoffer SASKATOON, Canada

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L. Van der Horst AMSTERDAM, Netherlands

N. S. Kline ORANGEBURG N. Y, U.S.A.

H. Laborit PARIS, France

Sir A. Lewis LONDON, Great Britain

J. Odegard OSLO, Norway

C. Radouco-Thomas QUEBEC, Canada

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C. H. Van Rhijnn ENSCHEDE. Netherlands

E. Rothlin BASEL, Switzerland

M. Shepherd LONDON, Great Britain

W. A. Stoll RHEINAU, Switzerland

J. Thuillier PARIS, France

E. Trabucchi MILAN, Italy

Honorary Members

E. Rothlin t

H. Hofft

J. Delay t

H. E. Lehmann

F. G. Valdecasas

J. Axelrod

E. Jacobson

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