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Program
Symposium 213
Tailored Therapies for IBD:A Look into the Future
October 5–6, 2018Milan Marriott HotelMilan, Italy
CME credits 10
Awarded with
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Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 6
Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
List of Speakers, Moderators and Scientific Organizers . . . . . . . . . . . . . . . . . . . . . . . 20
Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24
10 credit hours (CME) have been awarded for the Symposium 213 by the European Union of Medical Specialists (UEMS).
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PrefaceThe mechanisms underlying the chronic intestinal inflammation that is a hallmark of inflammatory bowel diseases (IBD) are complex. Advances in the understanding of IBD pathogenesis have resulted in the development of multiple biological agents that all represent an alternative to the use of current therapies in patients with refractory Crohn‘s disease or ulcerative colitis.
However biomarkers and patient stratification is key to personalize treatment in IBD. As clinicians we may oversimplify the complex nature of IBD and pay not enough attention to the heterogeneity of the pathophysiology and clinical presentation of these disorders. Taking into account specific risk factors, genetic phenotypes, pharmacokinetic characteristics, and other particular features unique to each patient would allow a personalized approach to manage the disease. Personalized medicine therefore represents the tailoring of the medical approach and treatment to the individual characteristics of each patient and is expected to become the paradigm of future healthcare.
The advancements in systems biology research and the rapid development of high-throughput technologies, as well as the characterization of different -omics, will contribute to a shift in modern biological and medical research from traditional hypothesis-driven designs toward data-driven studies and will facilitate the evolution of personalized or precision medicine for chronic diseases such as Crohn’s disease and ulcerative colitis.
The aim of this Falk Symposium is to dive into possibilities of personalized medicine for IBD patients. All speakers and moderators are internationally recognized IBD experts and build the basis for an up-to-date state-of-the-art symposium on IBD. The program is designed to provide opportunities for ample discussion and interaction with speakers, moderators and attendees.
We like to welcome you in Milan, the capital of tailors and designers, which will provide a perfect setup for a meeting on tailored therapies.
S. Danese A. Armuzzi A. Dignass P. Gionchetti
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Symposium 213
Tailored Therapies for IBD:A Look into the Future
October 5–6, 2018Milan Marriott HotelMilan, Italy
Start of Registration:Thursday, October 4, 201816.00 – 21.00 hat the congress office
Setting Up of Poster Session:Thursday, October 4, 201816.00 – 21.00 h
Congress Venue:Milan Marriott HotelVia Washington 6620146 MilanItaly
Symposium 213 is organized by Falk Foundation e.V.
Scientific Organization:Prof. Dr. Silvio DaneseIRCCS in GastroenterologyIstituto Clinico Humanitas IRCCSVia Manzoni 5620089 RozzanoItalyTelephone: +39-0282-2482-82Telefax: +39-0282-2451-01E-mail: [email protected]
Scientific Co-Organization:A. Armuzzi, Rome (Italy)A. Dignass, Frankfurt (Germany)P. Gionchetti, Bologna (Italy)
Official Language:English
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Friday, October 5, 2018
9.00 Welcome S. Danese, Milan
Session I Predicting good or bad prognosis
Chair: G. Fiorino, Milan; A. Sturm, Berlin
9.10 Genetic and clinical features for natural history V. Annese, Dubai
9.30 Endoscopy to tailor choices M. Daperno, Turin
9.50 Radiology to predict natural history G. Fiorino, Milan
10.10 Biomarkers and prognosis M.C. Dubinsky, New York
10.30 Coffee break with poster session
Session II Conventional therapies: Optimizing therapies to patient profiles
Chair: J. Lindsay, London; B. Siegmund, Berlin
11.00 Steroids: Old and new formulations S.P.L. Travis, Oxford
11.20 5-ASA in UC: Outdated or still state-of-the-art? A. Dignass, Frankfurt
11.40 Azathioprine: Outdated or still a valid option for F. Baert, UC and CD? Roeselare
12.00 Methotrexate in CD and UC after METEOR F. Carbonnel, Paris
12.20 Lunch break with poster session
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Friday, October 5, 2018 Session III Anti-TNF: A tailor made approach
Chair: M. Allez, Paris; F. Rizzello, Bologna
14.20 Predicting response: The best patient Y. Chowers, Haifa
14.40 Predicting loss of response I. Dotan, Petah Tikva
15.00 Optimizing anti-TNF therapy M. Ferrante, Leuven
15.20 Tailoring interruption of anti-TNF in IBD E. Louis, Liège
15.40 Coffee break with poster session
Session IV Vedolizumab and ustekinumab
Chair: R. Atreya, Erlangen; S. Schreiber, Kiel
16.10 Vedolizumab in UC: For all patients or best patient profile B.E. Sands, New York
16.30 Vedolizumab in CD: For all patients or best patient profile S. Schreiber, Kiel
16.50 Ustekinumab: Who and when? W.J. Sandborn, La Jolla
17.10 Safety of biologics in IBD: Recent updates S. Bonovas, Milan
17.30 State-of-the-Art Lecture: C. Fiocchi, Predicting the future of treatment for IBD Cleveland
18.00 Scientific discussion with snacks
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Saturday, October 6, 2018 Session V
New molecules Chair: F.J. Magro, Porto; G. Rogler, Zurich
9.00 JAKs R. Panaccione, Calgary
9.20 New anti-adhesion molecules S. Ghosh, Birmingham
9.40 Sphingosine-1-phosphate receptor modulators in the B.G. Feagan, treatment of IBD London, CA
10.00 Anti-fibrotic drugs for Crohn’s? G. Rogler, Zurich
10.20 New anti-IL23 blockers M.C. Fantini, Rome
10.40 Coffee break with poster session
Session VI Tailoring surgery to patients
Chair: W.A. Bemelman, Amsterdam; Y. Panis, Clichy
11.10 Tailoring surgery in UC: Always proctocolectomy A. D’Hoore, Leuven
11.30 Tailoring surgery in CD A. Spinelli, Milan
11.50 Perianal Crohn‘s disease S. Steele, Cleveland
12.10 Perioperative medications M. Vecchi, Milan
12.30 Presentation of Poster Awards S. Danese, Milan
A. Dignass, Frankfurt
12.50 Lunch break with poster session
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Saturday, October 6, 2018 Session VII
Challenging clinical scenarios Chair: A. Armuzzi, Rome; B.E. Sands, New York
14.00 Patient with previous cancer L. Beaugerie, Paris
14.20 A patient with previous opportunistic infections J. Lindsay, London
14.40 Crohn’s disease and tuberculosis in endemic areas F. Gomollón, Zaragoza
15.10 Fistulising CD: - Pro medical treatment P. Gionchetti, Bologna
- Pro surgical treatment P.G. Kotze, Curitiba
15.40 Closing remarks P. Gionchetti, Bologna
A. Armuzzi, Rome
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Poster Abstracts1.* Crohn’s and ulcerative colitis questionnaire-8 (CUCQ-8), a valid and quick
quality of life measure in IBD L. Alrubaiy, P. Dodds, H. Hutchings, J.G. Williams (Swansea, GB)
L. Alrubaiy, I. Arnott, A. Protheroe, M. Roughton, J.G. Williams (Swansea, Edinburgh, London, GB)
3. Clinicians‘ knowledge about the ionizing radiation of the common
L. Alrubaiy, A. Rikaby, S. Al-Rubaye, C.L. Ch’ng (Swansea, London, GB)
P. Andreev, O. Davydova (Samara, RU)
M. Artom, W. Czuber-Dochan, J. Sturt, H. Proudfoot, C. Norton (London, GB)
G. Balci, H. Cetinkaya, A. Ensari (Ankara, TR)
ulcerative colitis
bowel disease N. Bibani, H. Jelassi, M. Sabbah, D. Trad, A. Ouakaa, H. Elloumi, D. Gargouri (Tunis, TN)
10. An association between anti-Saccharomyces cerevisiae antibodies (ASCA)
(Ankara, TR)
association
disease N. Blazevic, M. Nikolic, A. Muslim, M. Zivkovic, I. Budimir, A. Biscanin, D. Hrabar, Z. Dorosulic (Zagreb, HR)
Turkey
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H. Cedron (Lima, PE)
Our 7 year outcomes and achievements
disease (PIBD) L. Cococcioni, O. Ogunmoye, S. Sider, R. Buckingham, S. Chadokufa,
colitis
I. Curlin, I. Romic (Dubrovnik, HR)
24. Characterising and managing issues with food-related quality of life in
(London, GB)
bowel diseases N. Danilova, M. Markelova, S. Abdulkhakov, T. Grigoryeva, A. Tyakht,
attack of ulcerative colitis O. Davydova, P. Andreev (Samara, RU)
(Bals, Craiova, RO)
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I.-G. Diaconu (Bals, Craiova, RO)
(Bals, Craiova, RO)
and treatment
D. Neagoe (Craiova, Bals, RO)
diseases
D. Neagoe (Craiova, Bals, RO)
D. Neagoe (Craiova, Bals, RO)
disease under treatment
G. Cullen, G. Doherty, J. Sheridan (Dublin, IE)
N. Elleuch, W. Dahmani, H. Jaziri, A. Ben Slama, A. Hammami, A. Brahem,
H. Elloumi, M. Ben Hmida, A. Belkhamsa, S. Ben Hmida, S. Bouaziz, I. Cheikh (Bizerte, TN)
H. Elloumi, M. Ben Hmida, S. Bouaziz, A. Belkhamsa, S. Ben Hmida , I. Cheikh (Bizerte, TN)
under long-term mesalamine treatment
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(Nizhny Novgorod, RU)
E. Fedulova (Nizhny Novgorod, RU)
age of onset
(Buenos Aires, AR)
H. Gdoura, A. Siala, M. Boudabous, L. Chtourou, A. Amouri, L. Mnif,
A. Badea (Craiova, Bals, RO)
women with endometriosis D. Gordienko (Rostov-on-Don, RU)
E. Gordienko (St. Petersburg, RU)
Y. Gu, Q. Wu, J. Zhong (Shanghai, CN)
M. Guney, M. Erdil, G. Basaranoglu, M. Basaranoglu (Istanbul, TR)
D. Habiba, M. Serguini, D. Saadouli, J. Boubaker (Tunis, TN)
L. Hamzaoui, H. Ayadi, M. Medhioub, A. Ben Mohamed, M. Mahmoudi,
(Nabeul, TN)
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Crohn‘s disease
M.M. Azouz (Nabeul, TN)
acute ulcerative colitis in the CONSTRUCT trial H. Hutchings, L. Alrubaiy, A. Watkins, W.-Y. Cheung, A.C. Seagrove, I.T. Russel, J.G. Williams (Swansea, GB)
G. Iliescu, M. Cheie, G. Tene, A. Iordache, A. Neagoe (Craiova, RO)
colitis (UC)
H.E. Johnson, S. McLaughlin (Bournemouth, GB)
referral center
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67. Protective effect of mesalazine on thromboembolic event risk in Crohn’s disease
(Ankara, TR)
69. Audit into the frequency of reactions to intravenous iron infusions
S. Bridger, J. Shutt (Dorchester, GB)
Z. Mahovne (Slavonski Brod, HR)
mucosal healing of ulcerative colitis
P. Radwan (Lublin, PL)
76. Colectomy-free survival and factors associated with it in children with ulcerative
R. Muhammed, S.-Y. Ong, W. Haller (Birmingham, GB)
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necrosis factor antagonist failure A. Muslim, M. Nikolic, J. Muslim, M. Zivkovic, N. Blazevic, I. Budimir, Z. Dorosulic, D. Hrabar, A. Biscanin (Sisak, Zagreb, HR)
biomarkEr
S. Crowe (Cambridge, London, GB)
disease
treatment
H. Cetinkaya (Ankara, TR)
Osijek, Zadar, HR)
clinical situations
A.R. Sydorchuk, R.I. Sydorchuk (Chernivtsi, UA)
in Crohn’s disease
M. Razov Radas (Zadar, HR)
S. Reif, T. Oron (Jerusalem, Petah Tikva, IL)
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treatment L. Rivas (Lima, PE)
90. Malnutrition in Tunisian Crohn‘s disease cohort H. Romdhane, B. Bouchabou, N. Bellil, H. Ben Nejma, R. Ennaifer (Tunis, TN)
H. Romdhane, B. Bouchabou, H. Ben Nejma, N. Bellil, R. Ennaifer (Tunis, TN)
C. Rowan, E. Brown, E. Ryan, C. Taylor, G. Doherty (Dublin, IE)
93. Risk factors for ocular involvement during Crohn‘s disease D. Saadouli, S. Yahyaoui, A. Sammoud, M.A. El Efrit (Tunis, TN)
D. Saadouli, S. Yahyaoui, A. Sammoud, M.A. El Efrit (Tunis, TN)
I. Sarvilina (Rostov-on-Don, RU)
bowel disease S. Shwana, I. Rikaby, L. Alrubaiy, M. Sageer, H. Hutchings, J.G. Williams
S. Shwana, I. Rikaby, L. Alrubaiy, H. Hutchings, J.G. Williams (Merthyr
M. Sladek, M. Chmielowska, A. Wasilewska, I. Herman-Sucharska,
storage disease 1B as an illustration M. Slae, M. Wilschanski (Jerusalem, IL)
M. Slae, P. Millman (Jerusalem, IL)
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bowel disease L. Sweeney, R. Moss-Morris, W. Czuber-Dochan, L. Meade, G. Chumbley, C. Norton (London, GB)
I.I. Sydorchuk (Chernivtsi, UA)
L.P. Sydorchuk, P.D. Fomin, R.I. Sydorchuk, O.M. Plehutsa, I. Sydorchuk,
R.I. Sydorchuk, P.D. Fomin, O.M. Plehutsa, L.P. Sydorchuk, I.I. Sydorchuk,
(Szeged, Debrecen, HU)
I. Tadin Hadjina, P.M. Zivkovic, A. Matetic, J.A. Borovac, J. Bukic, D. Rusic,
M. Tagle, Y. Scavino, E. Luna (Lima, PE)
R. Tamburic, J. Petkovic-Dabic, T. Barac, A. Dobrovoljski, S. Dabic, S. Trbojevic (Banja Luka, BA)
G.N. Tarasova, L. Mamedova (Rostov-on-Don, RU)
112. The role of stool genetic testing (SGT) for differential diagnosis of early stage IBD and IBS
(Bialystok, PL)
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(CONSTRUCT) J.G. Williams, A. Rikaby, M.F. Alam, L. Alrubaiy, I. Arnott, C. Clement, D. Cohen, J.N. Gordon, A.B. Hawthorne, M. Hilton, H. Hutchings, A. Jawhari, M. Longo,
Shor, S. Neuman, N. Levhar, E. Fudim, B. Avidan, L. Selinger, N. Orbach, O. Picard, M. Yavzori, A.R. Eliakim, S. Ben-Horin (Tel Aviv, IL)
and increased CRP in ulcerative colitis
ska-Ustymowicz, A. Pryczynicz (Bialystok, PL)
* = Posters of Distinction
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List of Speakers, Moderators and Scientific Organizers
Prof. Dr. Matthieu AllezService de GastroentérologieHôpital Saint-Louis1 Ave. C. Vellefaux75010 [email protected]
Dr. Vito AnneseValiant ClinicCity Walk, 13th StreetP.O. Box 414296 DubaiUnited Arab [email protected]
Dr. Alessandro ArmuzziIBD UnitFondazione Policlinico GemelliComplesso Integrato ColumbusUniversità CattolicaVia Moscati, 31-3300168 [email protected]
Prof. Dr. Raja AtreyaMedizinische Klinik IUniversitätsklinikum ErlangenUlmenweg 1891054 [email protected]
Dr. Filip BaertGastro-enterologieAZ Delta Campus WilgenstraatWilgenstraat 28800 [email protected]
Prof. Dr. Laurent BeaugerieDepartment of GastroenterologyHôpital Saint Antoine184, Rue du Faubourg St.-Antoine75571 [email protected]
Prof. Dr. Willem A. BemelmanDepartment of SurgeryUniv. van Amsterdam, Tytgat Institutefor Liver & Intestinal ResearchMeibergdreef 91105 AZ Amsterdam The [email protected]
Dr. Stefanos BonovasDepartment of GastroenterologyIstituto Clinico HumanitasHumanitas UniversityVia Manzoni 56 20089 [email protected]
Prof. Dr. Franck CarbonnelService d‘HépatogastroentérologieCHU de BicêtreUniversité Paris Sud78 rue du Général Leclerc94275 Le Kremlin-Bicê[email protected]
Dr. Yehuda ChowersDepartment of GastroenterologyRambam Medical CenterP.O. Box 960231096 [email protected]
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Prof. Dr. Silvio DaneseIRCCS in GastroenterologyIstituto Clinico Humanitas IRCCSVia Manzoni 5620089 [email protected]
Dr. Marco DapernoGastroenterology UnitMauriziano HospitalLargo Turati 6210128 [email protected]
Prof. Dr. André D‘HooreDepartment Abdominal SurgeryUniversity Hospital LeuvenHerestraat 493000 [email protected]
Prof. Dr. Axel DignassMedizinische Klinik IAGAPLESIONMarkus KrankenhausWilhelm-Epstein-Str. 460431 [email protected]
Prof. Dr. Iris DotanDivision of GastroenterologyRabin Medical CenterBeilinson Hospital39 Jabotinski St.49100 Petah [email protected]
Marla C. Dubinsky, M.D.Professor of PediatricsThe Susan & Leonard FeinsteinIBD Clinical Center 17 East 102nd Street, 5th Floor New York, NY [email protected]
Prof. Dr. Massimo C. FantiniDepartment of System MedicineUnit of GastroenterologyEd.E-Sud, Lab. E33University of Rome „Tor Vergata“Via Montpellier 100133 [email protected]
Dr. Brian G. FeaganRobarts Clinical Trials Inc100 Dundas Street, Suite 200London, ON N6A [email protected]
Prof. Dr. Marc FerranteGastroenterology and HepatologyUniversity Hospital LeuvenHerestraat 493000 [email protected]
Claudio Fiocchi, M.D.Professor of MedicinePathobiology / NC 20The Cleveland Clinic Foundation9500 Euclid AvenueCleveland, OH [email protected]
Dr. Gionata FiorinoIRCCS in GastroenterologyIstituto Clinico Humanitas IRCCSVia Manzoni 5620089 [email protected]
Prof. Dr. Subrata GhoshInstitute of Translational MedicineUniversity of BirminghamBirmingham B15 2TTGreat [email protected]
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Prof. Dr. Paolo GionchettiIstituto di Clinica e GastroenterologiaPoliclinico S. OrsolaUniversità di BolognaVia Massarenti 940138 [email protected]
Dr. Fernando GomollónHospital Clinico UniversitarioLosano BlesaAvenida San Juan Bosco 1550009 [email protected]
Dr. Paulo G. KotzeIBD Outpatient ClinicCatholic University of ParanáAv. Sao Jose, 300 - CEP [email protected]
Prof. Dr. James LindsayConsultant GastroenterologistBart‘s Health NHS TrustThe Royal London HospitalLondon E1 1BBGreat [email protected]
Prof. Dr. Edouard LouisGastro-entérologieC.H.U. Sart TilmanDomain du Sart Tilman4000 Liè[email protected]
Prof. Dr. Fernando J. MagroServico de GastroenterologiaHospital de S. JoaoAv. Prof. Hernani Monteiro4200-319 [email protected]
Prof. Dr. Remo PanaccioneInflammatory Bowel Disease ClinicRoom 6D30, TRW BuildingUniversity of Calgary3280 Hospital Drive N.W.Calgary, AB T2N [email protected]
Prof. Dr. Yves PanisService de Chirurgie ColorectaleHôpital Beaujon100, Bd. Général Leclerc92118 [email protected]
Prof. Dr. Fernando RizzelloDipartimento di Scienze Mediche e ChirurgicheS. Orsola-Malpighi HospitalUniversita di BolognaVia Massarenti 940138 [email protected]
Prof. Dr. Dr. Gerhard RoglerKlinik für Gastroenterologie& HepatologieUniversitätsspital ZürichRämistr. 1008091 Zü[email protected]
William J. Sandborn, M.D. Professor of MedicineDivision of GastroenterologyUniversity of California 9500 Gilman Drive, MC 0956La Jolla, CA [email protected]
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Bruce E. Sands, M.D.Professor of MedicineDepartment of GastroenterologyMount Sinai School of MedicineOne Gustave L. Levy PlaceNew York, NY [email protected]
Prof. Dr. Stefan SchreiberKlinik für Innere Medizin IUniversitätsklinikumSchleswig-Holstein, Campus KielArnold-Heller-Str. 3 (Haus 6)24105 [email protected]
Prof. Dr. Britta SiegmundMed. Klinik für Gastroenterologie, Infektiologie und RheumatologieCampus Benjamin Franklin (CBF)Charité UniversitätsmedizinHindenburgdamm 3012203 [email protected]
Prof. Dr. Antonino SpinelliUnità Operativa di Chirurgia Generale IIIIstituto Clinico Humanitas IRCCSVia Manzoni 5620089 [email protected]
Scott Steele, M.D.Colorectal SurgeryCleveland Clinic Main CampusMail Code A309500 Euclid AvenueCleveland, OH [email protected]
Prof. Dr. Andreas SturmInnere Medizin/GastroenterologieDRK-Kliniken WestendSpandauer Damm 13014050 [email protected]
Dr. Simon P.L. TravisDepartment of GastroenterologyOxford University HospitalsOxford OX3 9DUGreat [email protected]
Prof. Dr. Maurizio VecchiUniversity of Milan - IRCCSCa‘ Granda Ospedale MaggiorePoliclinico FoundationGastroenterology UnitVia Francesco Sforza 3520122 [email protected]
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Congress OfficeDuring Symposium 213
Congress Office Telephone: +49-175-7795-327
Opening Hours:Thursday, October 4, 2018 16.00 – 21.00 hFriday, October 5, 2018 8.00 – 18.00 hSaturday, October 6, 2018 8.30 – 16.00 h
Milan Marriott HotelVia Washington 6620146 MilanItaly
Admission to Scientific ProgramFor admission to scientific events your name badge should be clearly visible.
Conflicts of Interest Members of the scientific committee declare the following potential conflicts of interest:Alessandro Armuzzi: MSD, AbbVie, Allergan, Biogen, Celgene, Celltrion, Ferring, Hospira, Janssen, Lilly, Mundipharma, Pfizer, Samsung Bioepis, Sofar, Takeda, AstraZeneca, Chiesi, Medtronic, Mistsubishi Tanabe, Nikkiso, Otsuka, Tigenix, Zambon; Silvio Danese: AbbVie, Ferring, Hospira, Johnson and Johnson, Merck, MSD, Takeda, Mundipharma, Pfizer, Tigenix, UCB Pharma, Vifor, Biogen, Celgene, Allergan, Celltrion, Sandoz, Boehringer Ingelheim; Axel Dignass: Abbvie, MSD, Ferring, Roche, Takeda, Pharmacosmos, Vifor, Falk Pharma, Mundipharma, Janssen, Hospira, Robarts, Pfizer, Sandoz, Celgene, Tillotts, Falk Foundation, Otsuka, Immundiagnostik, Med Update GmbH, Medice, Wiley, Thieme, Allergosan, Pharmacosmos; Paolo Gionchetti: Janssen, Abbvie, Pfizer, Celgene, Takeda, Ferring, MSD, Alfa Wasserman, Amgen, Sofar, Chiesi
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AirportMilano Malpensa AirportDistance to hotel: 49 km; Taxi fare approx.: EUR 90http://www.milanomalpensa-airport.com/en
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ParkingThe hotel offers parking spaces on first come first serve basis. (2,10€ hourly, 15€ daily)
2019
International Symposia and Workshops
Scientific Dialogue in the Interest of Therapeutic Progress
Symposium 216Building Bridges in IBDBrussels, BelgiumSeptember 13–14, 2019
Symposium 217West Meets East:Functional Meets Organic Gastrointestinal DiseasesSingaporeNovember 29–30, 2019
WorkshopFrom Viral Hepatitis to ChronicInflammation and Liver CancerHeidelberg, GermanyFebruary 21–22, 2019
Symposium 214IBD: From Pathophysiology to Personalized MedicineOxford, Great BritainMarch 29–30, 2019
Symposium 215IBD: From Diagnosis to TherapySt. Petersburg, RussiaJuly 5–6, 2019
Congress DepartmentTel.: +49 (0)761/1514-125Fax: +49 (0)761/1514-359E-Mail: symposia@falk-foundation-symposia.orgwww.falk-foundation-symposia.org
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