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[email protected] Tamara Swigert, MSN, RN, CDE November 10, 2017

Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

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Page 1: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

[email protected]

Tamara Swigert, MSN, RN, CDENovember 10, 2017

Page 2: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Review possible causes of patient non-adherence

List examples of effective and ineffective communication techniques specific to patient encounters

Describe key concepts and skills of effective motivational interviewing and goal setting

Apply effective communication and Motivational Interviewing principles in patient encounters

After participating in this learning activity, the participant will be able to …

Page 3: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

The failure or refusal to comply: the failure or refusal to conform and adapt one's actions to a rule or to necessity.

Medicinenet: http://www.medicinenet.com/script/main/hp.asp

• Compliance is associated with the medical model• Connotes a 1-way relationship (provider/nurse tells

patient what to do)• Suggests a judgment on the patient, “does not do

what he/she is told”• Leads to frustration on the part of health care staff

Page 4: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

IDC-10 codes Z91.19: Noncompliance section (includes specifics such as: financial hardship, dietary, underdosing, intentional versus unintentional, etc.)

Page 5: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

We have all done it! But who does it help and where do we go from there?

Usually situation is more complicated (we need to look deeper)

Why do we do it?

RN report example: Mrs. Garcia is a 58-year old Hispanic female who is a noncompliant type 2 diabetic...

Page 6: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Unsure of how to take her

medication

Unable to afford the medication

Afraid of short/long-term

effects of treatment

Confused by the complicated treatment regimen

Unaware of seriousness of not taking (in

denial)

Unable to tolerate the side

effects of medication

Feeling overwhelmed or

depressed

Resistant to txplan due to

cultural/spiritual beliefs

Afraid of what others will think

Mrs. Garcia is a 58-year old Hispanic female with type 2 diabetes who is...

Page 7: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

• Implies a passive role, following demands of prescriber

• Clinician dominance

• Goal: obedience to clinician/ staff orders

• Activities are dictated; ptstold what they must do and lectured when they do not

• Noncompliers are judged as deviant, incompetent, lazy, or stubborn

• Resistance is discouraged

• Tools: persuasion, coercion

• Implies an active role, in collaboration with prescriber

• Clinician-patient collaboration

• Goal: patient self-mastery

• Activities are negotiated, plan matched to lifestyle of patient

• Self-motivated decision to stick to treatment advice

• Self-regulation of illness & treatment

• Resistance provides information for adaptation

• Tools: discussion, motivation, negotiation

Gould, E. (2010). P. 291

Page 8: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

*P<0.05 when compared to the 80-100% group

Sokol et al. Med Care (2005)

Page 9: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Increasing the effectiveness of adherence interventions may have a far greater impact on the health of

the population than any improvement in specific medical treatments.

World Health Organization (2003)

Page 10: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Communication is PROVIDER/NURSE centered, not PATIENT centered

We tell patient what he/she needs We speak much more than we listen We talk AT the patient, rather than discussing We establish clinical goals rather than considering

what is important to patient We assume our goals should be patient’s goals We do not take time to find out how illness (and

treatment) impacts patient

Page 11: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Resistance to change is seen as a handicap that we need to bury, vs. explore

Dictate (“you need to”) rather than negotiate (“what are you prepared to ...”) behavior change

Communication is rushed and one-sided

Prevalent attitude: Save the patient rather than patients save themselves

Patient’s “readiness to change” is rarely considered

Page 12: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

The World Health Organization has made a strong case that medication adherence is based on three

pillars: patient information, motivation, and behavioral skill requirements.

Information

Motivation

BehaviorChange

BehavioralSkills

World Health Organization (2003)

Page 13: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Technique Example

Ordering You are going to have to test four times per day.

Passing judgment I think it is wrong of you not to bring your husband.

Changing subject Let’s not talk about the diet issues right now.

False Hope Don’t worry, everything will work out fine.

Generalizations People always feel better once they get used to exercise.

Defensiveness Come on – no one here would intentionally lie to you.

Arguing How can you say you’re doing better when your A1c …

Aggressiveness It’s your own fault that you are here in the hospital.

Projecting I know how you feel. OR You don’t want to do that.

Dismissiveness You are making a big deal out of nothing.

Sarcasm Go ahead and have the pie; after all, who needs feet?

Page 14: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Technique Example

Active Listening Eye contact, relaxed posture

Observation You seem concerned about the change to your insulin.

Empathy It must be frustrating to have to change your routine …

Sharing Hope I have seen many patients who thought the same thing …

Humor Can diffuse tense situation, encourage, comfort

Silence Allows time to think; silence will encourage response

Provide info. Your A1c test result is 8.9%. The A1c tests tells us …

Clarifying What do you mean by “more that usual”?

Focusing Let’s look at what you ate for breakfast this morning …

Paraphrasing So it sounds like you are saying you are unsure about …

Active Listening Eye contact, relaxed posture

Page 15: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Reflective Listening Listen; avoid interrupting Paraphrase back what patient has said to show understanding: “It

sounds like you . . .” or “What you are saying is . . .” Open ended questions

Requires more than a one-word answer Use “Tell me . . . “What . . .” “How . . .” (avoid “Why” –

judgmental) Nonverbal communication (posture, proximity/position,

eye contact, etc.): biggest influence on message delivery Words used: 7% Tone of voice: 38% Body language: 55%

Affirmation Praise client’s efforts; acknowledge strengths Be genuine; genuine affirmation promotes self-efficacy

Page 16: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Talk to the patient: Avoid judgment Ask “What” instead of “Why” Ask open ended questions

Look for clues; use deductive reasoning skills (RNs are great with these)!

Avoid a rush to judgment (how many times have we been told by others that a patient has poor health due to their non-compliance?)

Page 17: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

• In the following examples, select the most likely adherence BARRIER the patient may be facing.

Mrs. Jones faithfully takes insulin and multiple other medicines during the day as prescribed. But every night before bed she gives only half of the prescribed dose. She lives alone.

1. Cost2. Knowledge deficit3. Fear of medication effects4. Regimen too complicated

Page 18: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

• In the following examples, select the most likely adherence BARRIER the patient may be facing.

Mr. Smith is willing to check glucose in the morning and before bed. He is open to the idea of mixed insulin BID but not AC/HS. He declines your invitation to participate in group classes.

1. Cost2. Stigma3. Fear of medication effect4. Regimen too complicated

Page 19: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

• In the following examples, select the most likely adherence BARRIER the patient may be facing.

Mr. Washington takes the full dose of his generic metformin and glyburide as directed, but cuts his Januvia (non-generic) in half and only takes it when he eats a big meal.

1. Cost2. Stigma3. Fear of medication effect4. Regimen too complicated

Page 20: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

“On a scale of 0-10, how important is it for you to … ?”

“On a scale of 0-10, how confident are you …?”

0 1 2 3 4 5 6 7 8 9 10

Readiness to Change is a measure of . . .●IMPORTANCE (“I want to”), AND …

●CONFIDENCE (“I believe I can”)

Case Management Adherence Guidelines (2006)

Page 21: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Group BLow

importance,High

Confidence

Group DHigh

Importance, High

Confidence

Group ALow

importance, Low

confidence

Group CHigh

importance, Low

confidence

Case Management Adherence Guidelines (2006)

Page 22: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Questions to ask: Why a 2 and not a 1? What makes you think this could be a problem? What are the downsides of making a change? What do you think the results of change might

be?

Tools & Interaction: Find what matters to patient Link positive health outcomes to what matters Don’t tell patient he/she is “wrong” Encourage “test your theory” (give it a try)

Case Management Adherence Guidelines (2006)

Page 23: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Adherence Intention is VARIABLEQuestions to ask: What things might get in the way of success? What can you do to overcome these barriers? What tools, skills, knowledge or adjustments do

you need to make this work?

Tools & Interaction: Break down into small short lessons, repeat Use demonstration with teach back Write it down Teach caregivers/supporters Praise patient efforts (build confidence)

Case Management Adherence Guidelines (2006)

Page 24: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

“A skillful clinical style for eliciting from patients their own motivation for making changes in the interest of their health”

Introduced by Miller & Rollnick in the early 1990s (for drug & alcohol addiction)

Shown to be successful for behavioral change in many applications (incl. chronic disease)

AMBIVALENCE and/or RESISTANCE are key opportunities to engage

Focuses on assessing and encouraging the patient’s motivation to change, NOT motivating the patient

Rollnick, Miller, & Butler, (2007) and Welch, Rose, & Ernst (2006)

Page 25: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Motivational Interviewing skills are matched with patient's readiness-to-change stage

Create a climate that is safe for patient to share, learn, change OR to challenge, question and reject the provider’s suggestions

Be honest with patients so they can make an informed choice (do not “sugar-coat”/soften or exaggerate)

Rollnick, Miller, & Butler, (2007) and Welch, Rose, & Ernst (2006)

Page 26: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

COLLABORATION: Partnership with focus on the client (patient) Shared decision making between client and provider

EVOCATIVE: Understanding client’s goals Connecting behavior change with what client values Use discrepancy between values and current

behavior to evoke reasons for change

CLIENT AUTONOMY: Client ultimately decides what to do We are inherently resistant to being told what to do Provider honors patient’s decision (regardless of own

feelings) Very tough! We must resist the “righting reflex”

(urge to fix things)

Rollnick, Miller, & Butler, (2007) and Welch, Rose, & Ernst (2006)

Page 27: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Roll with Resistance

Express Empathy

Avoid Argumentation

Develop Discrepancy

Support Self-Efficacy

Rollnick, Miller, & Butler, (2007) and Welch, Rose, & Ernst (2006)

Page 28: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Acknowledge that change is always hard for multiple reasons.

Explore why patient may not want to change current behavior… What are the good points about doing just what

you are doing now? Now what are the downsides of making this

change? Now what are the downsides of sticking with

what you are doing now and the upsides to making the change?

Page 29: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

PT: I don’t want to take another pill every day. Too much medicine isn’t good for you.

RN: It sounds like are worried about the amount of medicine you are on and that more could make things worse. Is that right?

PT: Right . . . I don’t want that to happen.

RN: I don’t blame you! Let’s talk about the good and bad sides of this medicine. Then you can decide, but at least you will have all the information.

Page 30: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Listen reflectively. Paraphrase or summarize what they have

said to show “you get it” Ask open ended questions. Do not say “I know how you feel” but rather,

“I can imagine that it must be …” Allow patient to “vent” (but not too much)

Page 31: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

PT: Everyone makes it sound like it is no big deal, but I am freaking out at all this stuff … change what I eat, check my blood, take this insulin, but watch out for low blood sugar …

RN: I can imagine you must feel very overwhelmed. You have been asked to make a lot of changes to manage this new diabetes and you are sure that you can do it all. Is that right?

PT: Yes, that is exactly right.

RN: Let’s break this down into some more manageable chunks. How about if we identify just the essentials for now?

Page 32: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Foster the TEAM approach (not you vs. them) Do not debate or “prove wrong”When correcting, ask permission to share

information. Assure patient that it is not your plan to force

them into anything but to give them information so that they can make an informed decision that fits them best.

Avoid judgmental language, posture, etc. (ask “what” instead of “why”)

Page 33: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

PT: Insulin is terrible for you! It causes kidneys to fail and heart attacks. I don’t want it!

RN: Sounds like you have some serious concerns about the safety of this stuff we want to give you, am I right?

PT: Yeah, that’s pretty much it. CDE: Well let me tell you, your are not the

only one to have those concerns! Can I tell you some things you might not know about this medicine?

PT: I guess so.

Page 34: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

This is what helps move the patient from resistance to action.

Identify (or help patient recognize) the things that are important to him/her (goals, values, dreams, etc.)

Highlight how current behavior is in conflict with those items.

Help patient see the disconnect with questions that allow patient to draw conclusions … “How do you think the way your diabetes is now syncs with what you want out of life?”

Page 35: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

RN: So, you were telling me about how you’d really like to go to college next year to study music. But you also said that you often forget your insulin and some of the times it makes you feel really sick and end up in the hospital with DKA.

PT: Yea, that’s true. RN: So what are your thoughts about how this

pattern can affect your goal of going to college next year?

PT: Well, I guess that if I really want to go …

Page 36: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

While you may be the diabetes expert, recognize the patient as the expert on his/her life and values

Allow patient to suggest next step, plan, goals, etc.

Acknowledge that roadblocks are likely to arise. Let patient know he/she has support and resources

Commend progress (even small) and emphasize that they should feel proud of what has been accomplished.

Respect the patient’s right to go against medical recommendations. Resist the “righting reflex” (this is VERY tough for those in the healthcare profession)

Page 37: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

PT: I have been thinking more about what you said about having to give myself shots.

RN: Great. Tell me what you have come up with.

PT: Well, taking insulin shots four times a day just isn’t going to be possible, but I think I might be able to do once a day.

RN: Sounds like a good place to start. How about if I show you how to do it? Then you can try yourself. In the meantime, let me talk to the doc and see what once daily options might work.

Page 38: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Setting goals are an important aspect of self-care

Start with some short term goals

Patients may need assistance in setting goals

Goals may need to be adjusted from time to time

Goals should be patients' goals, not RN/MDs’

Work on as few goals goal at a time as possible

Goals should be “S.M.A.R.T.” . . .

Page 39: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Specific• What do you expect to have happen?• Break large goals down into smaller ones

MeasureableHow will you know you are making progress?Use concrete measuring tools.

AttainableIs the goal realistic with your current resources?Aim for a goal that will not cause undue stress.

Relevant• Is this goal important to you personally?• Choose goal that will make a real difference.

Time-defined• How much time is scheduled to work on it?• Set a date on which you plan to complete goal.

Page 40: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Allow patient to direct communication; listen more Turn off the “fix-it” impulse; facilitate patient in

driver’s seat Always consider patient’s readiness to change Use effective communication techniques

Reflective listening Open-ended questions Non-verbal communication Affirmation

Use MI Skills Roll with Resistance Express Empathy Avoid Argumentation Develop Discrepancy Support Self-efficacy

Assist patient with setting S.M.A.R.T. goals

Page 41: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

48 y/o female, admitted for leg abscess, just diagnosed with type 2 DM while in the hospital.

A1C is 11.6% (just measured in hospital)Discharge Medication regimen: Metformin 1000

mg BID and 12 units Lantus QHSWhen you greet her and ask how she is doing

today, she breaks down into tears. She states that she is not doing well; she feels like there is no way she can handle all this.

She states that her mother died of diabetes and she does not think she can do this.

Page 42: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

68 y/o male, history of type 2 diabetes (13 years); admitted for acute renal injury; A1c: 9.2%

When you talk to him about his diabetes he tells you he checks his blood sugar at home three times a day and takes his insulin and pills as directed. States his blood sugar is always between 80 and 120.

He cannot tell you what his doses are but says he has them written on a paper at home.

Later admits that sometimes he forgets to check his blood sugar and to take his insulin because he gets too tired at night and falls asleep in front of the television.

To make small talk, he tells you about his golf game (he is proud of his skill and accomplishments on the golf course)

Page 43: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

19 y/o female, history of type 1 diabetes (7 yrs). Admitted for DKA (third time in 12 months)

A1C is 13.1% Mother is there. She tells you, “I am through! It

does not matter what I do, she just does not care. I tell her over and over what will happen to her if she keeps this up; maybe she will listen to you.”

Patient does not seem to want to engage. Seems despondent, even depressed. She does perk up when her friends come to visit and talk about a concert they are all planning to go to next month.

Home regimen: Basal/bolus (MDI) therapy. Levemir BID and NovoLog TID AC with a carb ratio of 8 and correction factor of 40. (no pump/CGM)

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Page 45: Tamara Swigert, MSN, RN, CDE - Sharp HealthCare€¢ Connotes a 1-way relationship (provider/nurse tells patient what to do) • Suggests a judgment on the patient, “does not do

Case Management Adherence Guidelines, version 2.0 (June, 2006). Case Management Society of America Accessed 7 Feb 2012 from http://www.cmsa.org/portals/0/pdf/CMAG2.pdf

Gould, E. (2010). Medication adherence is a partnership; medication compliance is not. Geriatric Nursing, 31 (4), 290-298. Morisky DE, Green LW, Levine DM. Med Care. 1986;24:67-74. (find in Case Management Adherence Guidelines, 2006)

Rollnick, Miller, & Butler, (2007). Motivational Interviewing in Healthcare. Guilford Press.

Sokol et al. (2005). Impact of medication adherence on hospitalization risk and healthcare cost. Medical Care 43(6), 521-530.

Welch, G., Rose, G., and Ernst, D. (2006). Motivational interviewing and diabetes: What is it, how is it used and does it work? Diabetes Spectrum, 19,1, 5-11. Accessed from http://spectrum.diabetesjournals.org/content/19/1/5.full on January 12, 2014.

World Health Organization (2003). Adherence to Long-Term Therapies: Evidence for Action. Accessed 7 May 2012 from http://whqlibdoc.who.int/publications/2003/9241545992.pdf