Team West Pharmaceutical Services Sponsors: Reginald Motley and Chris Evans Advisor: Dr. Singh BMEG:...
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West Pharmaceutical Services Reusable Injectable Drug Delivery Team West Pharmaceutical Services Sponsors: Reginald Motley and Chris Evans Advisor: Dr. Singh BMEG: Ryan O’Boyle, Madison DeFrank, and Derek Hunter MEEG: Hayley Shaw and Kailey Nelson BMEG450/MEEG401 12/11/1 3
Team West Pharmaceutical Services Sponsors: Reginald Motley and Chris Evans Advisor: Dr. Singh BMEG: Ryan O’Boyle, Madison DeFrank, and Derek Hunter MEEG:
Team West Pharmaceutical Services Sponsors: Reginald Motley and
Chris Evans Advisor: Dr. Singh BMEG: Ryan OBoyle, Madison DeFrank,
and Derek Hunter MEEG: Hayley Shaw and Kailey Nelson
BMEG450/MEEG401 12/11/13
Slide 2
Background 1 Pharmaceutical Packaging Systems 2012 Revenue:
$915million Market Leader Global Manufacturing Innovative and
Proven Product Portfolio Pharmaceutical Delivery Systems 2012
Revenue: $352 million Proprietary Devices/ Delivery System
Technologies Collaborative Development Contract Manufacturing
DevelopmentPrimary PackageAdministrationPatient 12/11/13
Slide 3
Motivation West hopes to expand their product line to include a
range of products that are reusable. This would reduce wastes and
overall costs 2 To research and develop a novel drive mechanism
that can be reset and move a piston in a 1 mL syringe for
dispensing of liquid Scope 12/11/13
Slide 4
Product Line 3 Confidose Disposable Spring, motor, manually
driven Easy to use At home use Not on market yet SmartDose SelfDose
12/11/13
Slide 5
Benchmarking Competing Products Unilife LISA Auto-injector
System BD Pen II Reusable Pen Cambridge Consultants Flexi-Ject
Auto-injector 4 12/11/13
Slide 6
Design Requirements 5 12/11/13
Slide 7
6 FINAL CONCEPT: Shape Memory Alloy FINAL CONCEPT: Shape Memory
Alloy Round 2 Neodymium Magnets Chemical Reaction Coil Wire/
Electromagnetic Force Round 2 Neodymium Magnets Chemical Reaction
Coil Wire/ Electromagnetic Force Round 1 Shape Memory Alloy Soft
Metal Alloy Flat Coil Spring Motor Driven Hydraulic Component Round
1 Shape Memory Alloy Soft Metal Alloy Flat Coil Spring Motor Driven
Hydraulic Component Top 2 Concepts Shape Memory Alloy Neodymium
Magnets Top 2 Concepts Shape Memory Alloy Neodymium Magnets Concept
Generation 12/11/13
Slide 8
Shape Memory Alloy Deformable alloy material Returns to
original shape when heated Nitinol = nickel + titanium Transition
temperature is 70-80 o C Nitinol springs used as driving force 7
12/11/13
Slide 9
Nitinol Spring Video 8 12/11/13
Slide 10
Preliminary Testing 1 Spring tested Two different vendors
Spring displacement held constant 9 Spring 2: Conclusion: Spring 2
provides a more cost effective solution. Spring 1: 12/11/13
Design Overview Lined with heat shielding tape Fiberglass tape
shields 260 o C Foil tape reflects 815 o C 8 stretchable Nitinol
springs 11.1 V battery pack 3.5 A through each spring High-amp
toggle switch 11 Top Platform Nitinol Springs Plunger Rod Bottom
Platform Syringe Inner Assembly 12/11/13
Slide 13
Design Overview 12 Prefilled syringe inserted through bottom
platform Locking platform secures syringe Springs supply up to 16.9
lb force Can be reset to prepare for new injection New syringe
inserted after injection Top Casing Inner Assembly External Casing
Locking Platform Syringe Outer Assembly 12/11/13
Cost Analysis 15 Purchased Parts Prototype Cost (per unit)
46.6% of Budget Spent 12/11/13
Slide 17
Path Forward 16 Optimize force generated: use Nitinol springs
of different composition Use ultra-capacitors in order to eliminate
the need for a large battery Coating in heat shielding material
during manufacturing stages Downsizing the system to maximize
compactness Incorporate automatic shut off system o Increase safety
o Decrease spring fatigue. 12/11/13
Slide 18
17 Thank you! Questions? 12/11/13
Slide 19
18 Delrin Polyoxymethylene (Acetel) Resin Melting point = 175 o
C Can be injection molded Manufacturing Cost Per Unit (1000 units
made) 56.1% Decrease! 12/11/13