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Technologies and expertise
InoCure is SME focused on RnD in field of drugdelivery, cell culture and tissue engineering
Expertise in:
Development of equipment for production ofnanofibers and nanoparticles.
Development of polymeric systems with drugdelivery function.
Evaluation of biological properties (in vitro and invivo).
Biomedical and tissue engineering application.
• Production of nano- andmicroparticles• Particles enable easy dispersion• Ideal for delivery of bioactivemolecules – systemic and topicaldelivery.• Combination with bulkpolymeric structures, hydrogelsand foams.
• Production of nano- andmicrofibrous non-woven textiles• Fibrous mesh enables topicalapplication.• Unique controlled releasepossibilities.• Structure resembles ECM = cellculture substrate.
formulations
Technology enables core/shell structure of particles:
Gelatin Polyvinyl alcohol
Aplications Molecules
Tissue engineering Growth factors
Nucleic acids
Pharmaceutics Drugs
Cosmetics Small molecules and proteins
Technology enables regulated delivery of active molecules.
Advantages of core/shell structure:
Protection of active agents from environmental damage
Improved control over release from particles and limitation of burst-release and higher loading capacity
En
zym
ati
c a
ctiv
ity
Core/shell Non-coaxial fibers
Nonpolar solvents
InoMATRIX is a scaffolding platform dedicated for use in cell culture,molecular biology and tissue engineering.
The main strengths of InoMATRIX include:
The 3D like environment supports cell growth.
High porosity and pore interconnection for optimal nutrient diffusion.
Regulated release of active substances for complex stimulation of cellprocesses.
Simple manipulation and compatibility with microscopic and microplate
based-assays.
Description
Morphology kit
The InoMATRIX Morphology kit offers up to date four different scaffolds made of poly-ɛ-caprolactone with different fibrous morphology:
nanofibrous scaffold with ̴ 200 nm fiber diameter
microfibrous scaffold with ̴ 5 µm fiber diameter
nano/microfibrous scaffold
nanoporous fibers with nanostructured surface
Morphology kitWB-F344 rat liver epithelial stem-like cells viability and
morphology testing on InoMATRIX Morphology Selectionplate
The results showed that InoMATRIX Selection plate scaffolds supportedadhesion, viability and metabolic activity of WB-F344 rat liver epithelialstem-like cells. The highest metabolic activity was observed on NF andPOR scaffolds.
Drug delivery
The second generation of nanofibers for cell culture
The unique feature of InoMATRIX products is a tunable releasesimulating physiological differentiation cascades.
The structure of fibers protects the embedded proteins, DNA,nanoparticles and drugs susceptible to environmental damage.
InoMATRIX technology is the only industrial scale core/shellelectrospining technology on market.
InoCure offers custom encapsulation of active molecules.
Aplications Molecules
Cell biology Growth factors
Molecularbiology
Nucleic acids
Pharmaceutics Drugs
Cosmetics Small molecules
Project ideas Organotypic 3D cell culture platform
Platform for nanoparticle and drug efficacy testing.
Model of skin, cornea, hepatic tissue.
Opthalmic drug delivery sytem
Treatment of AMD and diabetic retinopathy.
Delivery of anti-VEGF antibodies.
Contact information:www.inocure.czMatej BuzgoE: [email protected]: +420 775 952 233
InoCure is member of Ensof Groupwww.ensofgroup.eu
Thank you for your attention!
