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Spike timing-dependent plasticity Guoqiang Bi Department of Neurobiology University of Pittsburgh School of Medicine. Cajal, 1894. Temporally varying patterns of input. Spatially distributed patterns of storage. ???. - PowerPoint PPT Presentation
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Spike timing-dependent plasticity
Guoqiang Bi Department of Neurobiology University of Pittsburgh School of Medicine
When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that As efficiency, as one of the cells firing B, is increased.
Donald O. Hebb, 1949
Cells that fire together, wire togetherQuestion:
How precise do the cells need to fire together in order to wire together?
Spike-timing-dependent synaptic plasticity
How does the timing of pre- and postsynaptic activity affect synaptic modification?
STDP in neuronal networks
How may a network change its configuration according to the temporal structure of in input stimuli?
Temporal integration of STDP
How is a synapse modified by natural spike trains?
+ bicuculline+ CNQX & bicucullineA. Glu - Glu+ CNQX+ bicuculline & CNQXB. Glu - GABAS1 S2R2R1*S1 S2R2R1Synaptic connectivity between cultured neurons
Paired pre- and postsynaptic spiking a true Hebbian paradigm
ABCLTP induced by paired spiking with positive timing
ABCLTD induced by paired spiking with negative timing
Markram et al. 1997
A critical window for synaptic modificationinduced by correlated spikingBi & Poo 1998
Froemke & Dan 2002
Zhang et al. 1998
Feldman 2000
Nishiyama et al. 2000
Bell et al. 1997
Spike-timing-dependent synaptic plasticity
Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors
STDP in neuronal networksHow may a network change its configuration according to the temporal structure of in input stimuli?
Temporal integration of STDPHow is a synapse modified by natural spike trains?Spike-timing-dependent synaptic plasticity
Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors
STDP in neuronal networksHow may a network change its configuration according to the temporal structure of in input stimuli?
Temporal integration of STDPHow is a synapse modified by natural spike trains?
Correlated spiking at remote synapses through convergent polysynaptic pathways a delay-line mechanism
Polysynaptic pathways in small neural networks
Long-term pathway remodeling inducedby repetitive paired-pulse stimulation
IPI(ms): 1005020321SSensitivity of pathway remodeling to inter-pulse interval (IPI) of input stimuli
IPI(ms): 150656555321S4Dependence of pathway remodeling on inter-pulse interval (IPI) of input stimuli
Pathway remodeling induced bypaired-pulse stimuli of different IPIs
IPI1 IPI2IPI1 IPI2
LTP and LTD at remote synapses induced by local paired pulse stimulationA1A2B1B2
Spike-timing-dependent synaptic plasticity
Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors
Remote STDP in neuronal networks
STDP occurs at synaptic sites remote to network input nodesSpike timing within the network can be coordinated by delay-lines formed by polysynaptic pathways.
Temporal integration of STDPSpike-timing-dependent synaptic plasticity
Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors
Remote STDP in neuronal networks
STDP occurs at synaptic sites remote to network input nodesSpike timing within the network can be coordinated by delay-lines formed by polysynaptic pathways.
Temporal integration of STDP
Temporal integration of STDP theoretical considerationsPan-spike interactionNear-neighbor interaction
Temporal integration of STDP Triplet interactions
Bi & Poo 1998
Temporally asymmetric interaction between LTP- and LTD-inducing processes
Froemke & Dan 2002
Spike-timing-dependent synaptic plasticity
Paired pre- and postsynaptic spiking induces LTP and LTD, depending on the precise spike timingSTDP is sensitive to neuronal cell typeSTDP requires NMDA receptors
Remote STDP in neuronal networks
STDP occurs at synaptic sites remote to network input nodesSpike timing within the network can be coordinated by delay-lines formed by polysynaptic pathways.
Temporal integration of STDP
In hippocampal cultures, LTP- and LTD-inducing processes integrate asymmetricallyDifferent systems with the same spike-timing window may have different integration rules.
AcknowledgementsUC San Diego Mu-ming Poo (Berkeley) Benedikt Berninger (Munich)
University of Pittsburgh Pakming Lau Huaixing Wang Joyeeta Dutta David Nauen
Needs update