Test Development and Advisory Committee Acceptable Abbreviations and Terminology

Page 2 – Anatomic Pathology Page 3 – Blood Banking Page 4 – Chemical Pathology Page 5-6 – Cytopathology Page 7 – Dermatopathology Page 8 – Forensic Pathology Page 9-10 – Hematology Page 11 – Management and Informatics Page 12 – Medical Microbiology Page 13 – Molecular Genetic Pathology Page 13 – Neuropathology Page 15 – Pediatric Pathology Pages 16-19 – AP Path CertLink Pages 20 – 25 – compilation of TDAC abbreviations 11/2/2017 Page 26 – TDAC notes Pages 27 – 32 – Generic list of abbreviations

Updated 1/2018 The Anatomic Pathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology ACTH adrenocorticotrophic hormone AFP alpha fetoprotein AIDS acquired immunodeficiency syndrome AJCC American Joint Commission on Cancer ANA antinuclear antibody ANCA anti-neutrophil cytoplasmic autoantibody ASCO/CAP American Society of Clinical Oncology/College of American Pathologists Beta-HCG beta-human chorionic gonadotropin CBC complete blood count CK cytokeratin CLL chronic lymphocytic leukemia CMV cytomegalovirus DCIS ductal carcinoma in situ DNA deoxyribonucleic acid EBER Epstein-Barr encoding region EBV Epstein Barr virus EGFR epidermal growth factor receptor EM electron microscopy EMA epithelial membrane antigen ER estrogen receptor EVG elastic van Gieson 5FU fluorouracil GIST gastrointestinal stromal tumor GMS Gomori methenamine silver HHV8 human herpes virus 8 HIV human immunodeficiency virus HPV human papillomavirus HSIL high grade squamous intraepithelial lesion IHC immunohistochemistry INR international normalized ratio IUD intrauterine device IV intravenous LCIS lobular carcinoma in situ LSIL low grade squamous intraepithelial lesion MALT mucosa-associated lymphoid tissue NK natural killer NOS not otherwise specified NUT nuclear in testis PAS periodic acid Schiff PEComa perivascular epithelioid cell PIN prostatic intraepithelial neoplasia PLAP placental alkaline phosphatase PR progesterone receptor PSA prostate specific antigen TTF-1 thyroid transcription factor TUR transurethral resection WBC white blood cell count WT1 Wilms tumor associated antigen Down the road, Wegener granulomatosis should be changed to granulomatosis with polyangiitis. There is no dash in “S100 protein”. PNET now Ewing sarcoma – 1/2016 Granulocytic sarcoma now myeloid sarcoma – 1/2016

Updated 2/2018 The Blood Banking/Transfusion Medicine Test Development and Advisory Committee

Acceptable Abbreviations and Terminology

ACE inhibitors angiotensin converting enzyme inhibitors ADAMTS13 a disintegrin & metalloprotease with a thrombospondin type 1 motif, member 13 AHF antihemophilia factor AHG antihuman globulin aPTT activated partial thromboplastin time BMT bone marrow transplant BNP B-type natriuretic peptide CAP College of American Pathologists CBC complete blood count CD cluster designation CLIA Clinical Laboratory Improvements Amendments CMV cytomegalovirus CONSORT consolidated standards of reporting trials CT computerized tomography CXR chest x-ray DAT direct antiglobulin test DDAVP 1-desamino-8-D-arginine vasopressin (desmopressin) DVT deep vein thrombosis EIA enzyme immunoassay EKG echocardiogram EPO erythropoietin FDA Food & Drug Administration FFP fresh frozen plasma G-CSF granulocyte colony stimulating factor GI gastrointestinal GVHD graft vs. host disease H1 & H2 histamine 1 & 2 HBV hepatitis B virus HCV hepatitis C virus HDFN hemolytic disease of the fetus and newborn HIV human immunodeficiency virus HLA human leukocyte antigen HPA human platelet antigen HPC hematopoietic progenitor cell HTLV human T-lymphotropic virus ICU intensive care unit IgG immunoglobulin G INR international normalized ratio ITP immune thrombocytopenic purpura IVIG intravenous immune globulin LDH lactate dehydrogenase LISS low ionic strength solution MRI magnetic resonance imaging NAT nucleic acid amplification test PEG polyethylene glycol PLT platelet PO per oral PT prothrombin time RBC red blood cell RhIG Rh immune globulin RPM revolutions per minute TACO transfusion associated circulatory overload TRALI transfusion related acute lung injury TTP thrombotic thrombocytopenic purpura VWF von Willebrand factor WBC white blood cell/count Change Coombs to AHG Change Aprotinin to DDAVP Rh negative, not Rh-

Updated 2/2017

The Chemical Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology

ACTH adrenocorticotropic hormone ADH antidiuretic hormone AFP alpha fetoprotein ALT alanine aminotransferase ANA antinuclear antibody AST aspartate aminotransferase BNP B-type natriuretic peptide CBC complete blood count CDC Centers for Disease Control CEA carcinoembryonic antigen CK-MB creatine kinase-muscle or brain type CLIA Clinical Laboratory Improvements Amendments CLSI Clinical Laboratory Standards Institute CMS Center for Medicare and Medicaid Services CPT Current Procedural Terminology CSF cerebrospinal fluid DRG diagnosis related group EDTA ethylenediaminetetraacetic acid FDA Food & Drug Administration HbX etc. hemoglobin A1c, C, D, E, S, etc. hCG human chorionic gonatotrophin HCT hematocrit HDL high density lipoprotein cholesterol HGB hemoglobin HIPAA Health Insurance Portability and Accountability Act HLA human leukocyte antigen HPLC high performance liquid chromatography ICD-10 international classification of diseases version 10 IDL intermediate density lipoprotein cholesterol IgA etc. immunoglobulin A, D, E, G, M IL-1 etc. interleukin 1 INR international normalized ratio K2 EDTA K2 ethylenediaminetetraacetic acid LC-MS/MS liquid chromatography tandem mass spectrometry LD lactate dehydrogenase LDL low density lipoprotein cholesterol MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MCV mean corpuscular volume NT-ProBNP N-terminal pro-B-type natriuretic peptide OSHA Occupational Safety and Health Administration PAMG-1 placental alpha microglobulin-1 POC point of care PSA prostate specific antigen PTH parathyroid hormone RBC red blood cell count rpm revolutions per minute SS-A/Ro Anti-SSA autoantibodies SS-B/La Anti-SSB autoantibodies TSH thyroid stimulating hormone VIPoma vasoactive intestinal polypeptide VLDL very low density lipoprotein cholesterol Change “autoanalyzer” to “chemistry analyzer” Enzyme units are always U/L and hormones and proteins of unknown molecular weight are IU/L.

Updated 8/2017 The Cytopathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology AFB acid-fast bacilli AGC atypical glandular cells AIS adenocarcinoma in situ ALTS ASCUS/LSIL triage study ASCCP American Society for Colposcopy and Cervical Pathology ASC-H atypical squamous cells, cannot rule out high grade squamous intraepithelial lesion ASC-US atypical squamous cell of undetermined significance ATA American Thyroid Association ATHENA addressing the need for advanced HPV diagnostics AUS/FLUS atypia of undetermined significance/follicular lesion of undetermined significance BAL bronchoalveolar lavage BCG Bacillus Calmette-Guérin BSO bilateral salpingo-oophorectomy CAIX carbonic anhydrase IX CDC Centers for Disease Control and Prevention CEA carcinoembryonic antigen CK cytokeratin CLIA Clinical Laboratory Improvement Amendments CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMS Center for Medicare and Medicaid Services CMV cytomegalovirus COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computerized tomography EBUS endobronchial ultrasound EMA epithelial membrane antigen ER estrogen receptor ERCP endoscopic retrograde choledochopancreatic duodenography ERG ETS (erythroblast transformation specific)-related gene EUS endoscopic ultrasound FDA Food and Drug Administration FISH fluorescent in-situ hybridization FNA fine needle aspiration FLI1 Friend leukemia integration 1 transcription factor GATA3 guanine adenine thymine adenine transcription factor 3 GFAP glial fibrillary acidic protein GIST gastrointestinal stromal tumor GMS Grocott methenamine silver HCC hepatocellular carcinoma Hep Par-1 hepatocyte paraffin-1 hpf high power field HPV human papilloma virus HSIL high grade squamous intraepithelial lesion IHC immunohistochemistry INR international normalized ratio IPMN intraductal papillary mucinous neoplasm LCA leukocyte common antigen LDH lactate dehydrogenase LEEP loop electrocautery excision procedure LEF1 lymphoid enhancer binding factor 1 LSIL low grade squamous intraepithelial lesion LMP last menstrual period Continued on next page

MALT mucosa associated lymphoid tissue MASC mammillary analogue secretory carcinoma MEN multiple endocrine neoplasia N/C ratio nuclear cytoplasmic ratio NF neurofibromatosis NGS next generation sequencing NILM negative for intraepithelial lesion or malignancy NK natural killer OSHA Occupational Safety and Health Administration panCK pancytokeratin panNET pancreatic neuroendocrine tumor PAS periodic acid Schiff PET positron emission tomography PLAG1 pleomorphic adenoma gene 1 PLAP placental alkaline phosphatase PNET primitive neuroectodermal tumor PR progesterone receptor PSA prostate specific antigen PSMA prostate specific membrane antigen PTAH phosphotungstic acid hematoxylin PTH parathormone RCC renal cell carcinoma (where appropriate) SMA smooth muscle actin TAH total abdominal hysterectomy TB tuberculosis TJC The Joint Commission TTF1 thyroid transcription factor 1 VHL Von Hippel-Lindau Pap test – should be - liquid-based cervical cytology (don’t summarily change old questions). Anal Pap – should be - liquid-based anal cytology. For Pap/GYN/anal/urine screening questions, the stem should read “What is the best interpretation (not dx)?”. Diagnostic cytology the stem should read “What is the most likely diagnosis?”. All GYN questions that have “recommended follow-up” should include “most recent ASCCP guidelines”. 2007 NCI Thyroid Conference = National Cancer Institute Thyroid FNA State of the Science Conf. This is now changed to “The Bethesda System for Reporting Thyroid Cytopathology”. MFH – now – pleomorphic undifferentiated sarcoma. Metastatic goblet cell carcinoid tumor – now- metastatic mixed adenoneuroendocrine carcinoma. When appropriate, answer order should be: unsatisfactory, benign, atypical, suspicious, and malignant – not alpha. Virtual slides should be FNAs, not scrapes. Avoid SurePath for virtual microscopy. New term – secretory carcinoma (MASC – mammillary analogue secretory carcinoma).

Updated 11/2017 The Dermatopathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology CAP College of American Pathologists CD1 cluster designation CK cytokeratin CLIA Clinical Laboratory Improvements Amendments CMV cytomegalovirus CPT current procedural terminology DNA deoxyribonucleic acid EBV Epstein-Barr virus EMA epithelial membrane antigen ERG Electroretinography or Ergosterol FDA Food & Drug Administration GFAP Glial Fibrillary Acidic Protein HHV human herpes virus HPV human papillomavirus HSV herpes simplex virus IgA immunoglobulin A IgD immunoglobulin D IgE immunoglobulin E IgG immunoglobulin G IgM immunoglobulin M LEOPARD Lentigines, EKG abnormality, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retarded growth, Deafness (congenital syndrome) MiTF Microphthalmia Transcription Factor MUM-1 Multiple Myeloma Oncogene 1 MYC myelocytomatosis NF neurofibromatosis PAS stain periodic acid Schiff PEComa perivascular epithelioid cell PLEVA pityriasis lichenoides et variolaformis acuta

TNF- tumor necrosis factor alpha “follicular lymphoma” not “follicle cell lymphoma” according to WHO

Updated 5/2017 The Forensic Pathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology 25I-NBOMe derivative of the phenethylamine hallucinogen 2C-I (N-bomb, Smiles, 25I, 25C, 25B) ACLS advanced cardiovascular life support ACTH adrenocorticotrophic hormone AIDS acquired immune deficiency syndrome AV atrioventricular AVM arteriovenous malformation CMV cytomegalovirus CPR cardiopulmonary resuscitation CT computed tomography D-MORT Disaster Mortuary Operational Response Teams ED emergency department EDTA ethylenediaminetetraacetic acid EEG electroencephalogram EKG electrocardiogram EPA environmental protection agency HACEK Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella HBV hepatitis B virus Hib Haemophilus influenzae, serotype b HIPAA Health Insurance Portability and Accountability Act HPV human papilloma virus IHC immunohistochemical IVDA intravenous drug abuser MDMA methylenedioxymethamphetamine (Ecstacy) MRI magnetic resonance imaging MVC motor vehicle collision NAME National Association of Medical Examiners NYCLAD nylon clad bullet OSHA Occupational Safety and Health Administration OTC over the counter PTSD post-traumatic stress disorder THC Tetrahydrocannabinol TORCH (T)oxoplasmosis, (O)ther agents, (R)ubella, (C)ytomegalovirus, and (H)erpes simplex “TASER” should be changed to electronic control device.

The Hematopathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology - Updated 2/2018

ADP adenosine diphosphate ALK anaplastic lymphoma kinase ALL acute lymphoblastic leukemia AML acute myeloid leukemia aPTT activated partial thromboplastin time ATP adenosine triphosphate CAP College of American Pathologists CBC complete blood count CLIA Clinical Laboratory Improvements Amendments CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMV cytomegalovirus CNS central nervous system CSF cerebrospinal fluid DNMT3A DNA methyltransferase 3 alpha DVT deep vein thrombosis EBER EBV-encoded RNA EBV Epstein-Barr virus ED emergency department EDTA ethylenediaminetetraacetic acid ELISA elisa assay EMA epithelial membrane antigen FDA Food & Drug Administration FISH fluorescence in-situ hybridization G-6-PD glucose-6-phosphate dehydrogenase GMS Gomori methenamine silver Hb or Hgb hemoglobin HHV8 human herpesvirus 8 HPLC high-performance liquid chromatography IHC immunohistochemistry INR international normalized ratio MALT lymphoma mucosa-associated lymphoid tissue lymphoma MCH mean corpuscular hemoglobin MCHC mean corpuscular hemoglobin concentration MCV mean corpuscular volume MDS myelodysplastic syndrome MDS/MPN myelodysplastic/myeloproliferative neoplasms MGUS monoclonal gammopathy of undetermined significance MLL (KMT2A) mixed lineage leukemia MPN myeloproliferative neoplasms MPO myeloperoxidase MRD minimal residual disease NGS next generation sequencing NOS not otherwise specified NPM1 nucleophosmin gene PAS periodic acid Schiff PCR polymerase chain reaction PMF primary myelofibrosis PNH paroxysmal nocturnal hemoglobinuria Ph’ chromosome Philadelphia chromosome Plt platelet PT/INR prothrombin time/international normalized ratio PTLD post-transplant lymphoproliferative disorders QC quality control RAEB refractory anemia with excess blasts RARS refractory anemia with ring sideroblasts RBC red blood cell Continued on next page

RDW red cell distribution width RNA ribonucleic acid RT-PCR reverse transcriptase polymerase chain reaction SLL small lymphocytic lymphoma SNP single nucleotide polymorphism TCR T cell receptor TdT terminal deoxynucleotidyl transferase TIA1 T cell intracellular antigen 1 TIBC total iron binding capacity WBC white blood cell

Updated 4/2018

The Management and Informatics Test Development and Advisory Committee Acceptable Abbreviations and Terminology

ACGME Accreditation Council for Graduate Medical Education ACO accountable care organization aPTT activated partial thromboplastin time ASAP as soon as possible ASCII American Standard Code for Information Interchange CAP College of American Pathologists CBC complete blood count CDC Centers for Disease Control CLIA Clinical Laboratory Improvements Amendments CMS Centers for Medicare/Medicaid CPOE computerized provider order entry CPT Current Procedural Terminology CSF cerebrospinal fluid CV coefficient of variation DICOM Digital Imaging and Communications in Medicine EMR electronic medical record – do not use EHR and change old questions individually, as warranted ER estrogen receptor FDA Food and Drug Administration FTE full-time equivalent H & E hematoxylin and eosin HIPAA Health Insurance Portability and Accountability Act HIS hospital information system HL7 Health Level 7 HMO health maintenance organization HPV human papillomavirus HTML hypertext markup language HTTP hypertext transfer protocol ICD International Classification of Diseases IHC immunohistochemistry IRB institutional review board ISBT 128 international standard based on the Code 128 Barcode for the transfer of information associated with blood transfusion, cellular therapy and tissue transplantation IT information technology JPEG joint photographic experts group LIS laboratory information system LOINC Logical Observation Identifiers Names and Codes MCV mean corpuscular volume OSHA Occupational Safety and Health Administration PDF portable document format PHI protected health information PR progesterone receptor QA quality assurance QC quality control RFP request for proposal RBC red blood cells ROC receiver operator curve SD standard deviation SNOMED Systemized Nomenclature of Medicine STAT from the Latin word statum, meaning 'immediately' SWOT strengths, weaknesses, opportunities, threats TAT turn-around time TIFF Tagged Image File Format VPN virtual private network WBC white blood cells Per the 2017 TDAC, it is now back to The Joint Commission. Per the 2014 TDAC, TJC will no longer be used as an abbreviation for The Joint Commission. It will be referred to as Joint Commission, with no abbreviation.

Updated 4/2018 The Medical Microbiology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology

ADH arginine dihydrolase (SS only) AFB acid-fast bacilli AIDS acquired immunodeficiency syndrome AML acute myeloid leukemia ARDS acute respiratory distress syndrome BAL bronchoalveolar lavage BCYE buffered charcoal yeast extract CAMP Christie-Atkins-Munch-Petersen test CLSI Clinical Lab Standards Institute CMV cytomegalovirus CNA colistin nalidixic acid CNS central nervous system COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computed tomography DNA deoxyribonucleic acid EBV Epstein-Barr virus EIA enzyme immunoassay ELISA enzyme-linked immunosorbent assay G6PD glucose-6-phosphate dehydrogenase deficiency GMS Gomori (or Grocott) methenamine silver H & E hematoxylin & eosin HAART highly active antiretroviral therapy HBV hepatitis B virus HHV human herpes virus HIV human immunodeficiency virus HSV herpes simplex virus IgA etc. immunoglobulin A, D, E, G, M IGRA interferon gamma release assay LDC lysine decarboxylase test (SS only) MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MIC minimal inhibitory concentration MRI magnetic resonance imaging NAAT nucleic acid amplification test ODC ornithine decarboxylase (SS only) ONPG 2-Nitrophenyl-β-D-galactopyranoside PAS periodic acid Schiff PCR polymerase chain reaction PYR pyrrolidonyl amidase reactivity RNA ribonucleic acid RPR rapid plasma reagin RSV respiratory syncytial virus SBA sheep blood agar (SS only) TCBS agar thiosulfate-citrate-bile salts-sucrose agar TPPA treponema pallidum agglutination assay VDRL venereal disease research laboratory test VZV varicella zoster virus When referring to the Gram stain, it should be capitalized. When referring to the gram reactivity of an organism, gram-negative or gram-positive, it is not capitalized. When writing a “sp.” or “spp.”, the entire name is not italicized.

Updated 8/2017

The Molecular Genetic Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology

aCGH array comparative genomic hybridization ACMG American College of Medical Genetics and Genomics AFP alpha fetoprotein ALL acute lymphoblastic leukemia AML acute myeloid leukemia BAC baculovirus array CAP College of American Pathologists CBC complete blood count CLIA Clinical Laboratory Improvement Amendment CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMV cytomegalovirus CpG CpG (?) islands CPT current procedural terminology CSF cerebrospinal fluid CT computed tomography DNA deoxyribonucleic acid EBV Epstein-Barr virus FISH fluorescent in-situ hybridization HbF hemoglobin F HbS hemoglobin S HBV hepatitis B virus HCV hepatitis C virus HIV human immunodeficiency virus HPV human papillomavirus HSV herpes simplex virus IGH immunoglobulin heavy chain IHC immunohistochemical LOH loss of heterozygosity MCV mean corpuscular volume MEN multiple endocrine neoplasia MRI magnetic resonance imaging NGS next generation sequencing PCR polymerase chain reaction RNA ribonucleic acid rRNA ribosomal ribonucleic acid SNP single nucleotide polymorphism STR short tandem repeat Tm melting temperature Fusion genes will be noted with a slash not a dash. ABL is now ABL1. Next generation sequencing (not high-throughput or massively parallel). Chromosomal microarray, not chromosome microarray

Updated 3/2018 The Neuropathology Test Development and Advisory Committee

Acceptable Abbreviations and Terminology AIDS acquired immune deficiency syndrome ALS amyotrophic lateral sclerosis ATRX alpha thalassemia/mental retardation syndrome X-linked CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy CD cluster designation CJD Creutzfeldt Jakob disease CMV cytomegalovirus CNS central nervous system COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computerized tomography DNA deoxyribonucleic acid EEG electroencephalogram EGFR epidermal growth factor receptor EM electron microscopy EMA epithelial membrane antigen EMG electromyography FDG-PET fluoro-deoxyglucose positron emission tomography GFAP glial fibrillary acidic protein GI gastrointestinal H & E hematoxylin & eosin HIV human immunodeficiency virus HSV herpes simplex virus IHC immunohistochemical LFB luxol fast blue MDMA methylenedioxymethamphetamine (Ecstasy) MR magnetic resonance MRI magnetic resonance imaging NMO neuromyolitis optica PLAP placental alkaline phosphatase PPD test purified protein derivative PTAH phosphotungstic acid hematoxylin SPECT single photon emission tomography TDP-43 TAR DNA binding protein 43 TTF1 thyroid transcription factor WHO World Health Organization Immunoreactive “to” not “for”. EM only for nerve and muscle and selected diseases in which EM is required. 2017 – Lhermitte-Duclos is now dysplastic cerebellar gangliocytoma; new term - solitary fibrous tumor/hemangiopericytoma

Updated 8/2016

The Pediatric Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology

ALT alanine aminotransferase AST aspartate aminotransferase CBC complete blood count CHARGE syndrome coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness. CSF cerebrospinal fluid DNA deoxyribonucleic acid ESR erythrocyte sedimentation rate FISH fluorescent in-situ hybridization G6PD glucose-6-phosphate dehydrogenase deficiency GM-CSF granulocyte-macrophage colony-stimulating factor HUS hemolytic uremic syndrome IgA immunoglobulin A IgD immunoglobulin D IgE immunoglobulin E IgG immunoglobulin G IgM immunoglobulin M IPEX immunodysregulation polyendocrinopathy enteropathy x-linked syndrome MEN IIb multiple endocrine neoplasia type 2 mRNA messenger ribonucleic acid NF neurofibromatosis PAS periodic acid Schiff PEComa perivascular epithelioid cell tumor VACTERL vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities VMA vanillylmandelic acid WAGR Wilms tumour, aniridia, genitourinary anomalies, and retardation WBC white blood cell If a syndrome is named after a patient, there is an apostrophe – Lou Gehrig’s disease. If it is named after the doctor, there is no apostrophe.

AP Path CertLink ACGME Accreditation Council for Graduate Medical Education ACLS advanced cardiovascular life support ACTH adrenocorticotrophic hormone ADAMTS13 a disintegrin & metalloprotease with a thrombospondin type 1 motif, member 13 ADP adenosine diphosphate AFB acid-fast bacilli AFP alpha fetoprotein AIDS acquired immunodeficiency syndrome AJCC American Joint Commission on Cancer ALK anaplastic lymphoma kinase ALL acute lymphoblastic leukemia ALS amyotrophic lateral sclerosis ALT alanine aminotransferase AML acute myeloid leukemia ANA antinuclear antibody ANCA anti-neutrophil cytoplasmic autoantibody aPTT activated partial thromboplastin time ARDS acute respiratory distress syndrome ASC-H atypical squamous cells, cannot rule out high grade squamous intraepithelial lesion ASC-US atypical squamous cell of undetermined significance AST aspartate aminotransferase ATP adenosine triphosphate AVM arteriovenous malformation BAL bronchoalveolar lavage BCG Bacillus Calmette-Guérin (therapy changes or vaccine) Beta-HCG beta-human chorionic gonadotropin BSO bilateral salpingo-oophorectomy CAIX carbonic anhydrase IX CAP College of American Pathologists CBC complete blood count CD cluster designation CDC Centers for Disease Control CEA carcinoembryonic antigen CHARGE syndrome coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness CK cytokeratin CK-MB creatine kinase-muscle or brain type CLIA Clinical Laboratory Improvements Amendments CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMS Center for Medicare and Medicaid Services CMV cytomegalovirus CNS central nervous system COPD chronic obstructive pulmonary disease CPR cardiovascular resuscitation CPT Current Procedural Terminology CSF cerebrospinal fluid or colony-stimulating factor CT computed tomography CXR chest x-ray DAT direct antiglobulin test DCIS ductal carcinoma in situ DDAVP 1-desamino-8-D-arginine vasopressin (desmopressin) DNA deoxyribonucleic acid DVT deep vein thrombosis EBER EBV-encoded RNA

EBUS endobronchial ultrasound EBV Epstein-Barr virus ED emergency department EDTA ethylenediaminetetraacetic acid EEG electroencephalogram EGFR epidermal growth factor receptor EKG echocardiogram ELISA elisa assay EM electron microscopy EMA epithelial membrane antigen EMG electromyograph EMR electronic medical record – do not use EHR and change old questions individually, as warranted EPA environmental protection agency EPO erythropoietin ER estrogen receptor ERCP endoscopic retrograde choledochopancreatic duodenography ERG Electroretinography or Ergosterol ESR erythrocyte sedimentation rate EVG elastic van Gieson FDA Food & Drug Administration FDG-PET fluoro-deoxyglucose positron emission tomography FISH fluorescent in-situ hybridization FNA fine needle aspiration FTE full-time equivalent G6PD glucose-6-phosphate dehydrogenase deficiency GATA3 guanine adenine thymine adenine transcription factor 3 GFAP glial fibrillary acidic protein GI gastrointestinal GIST gastrointestinal stromal tumor GMS Gomori (or Grocott) methenamine silver Hb or HgbX etc. hemoglobin A1c, C, D, E, F, S, etc. HBV hepatitis B virus HCC hepatocellular carcinoma hCG human chorionic gonatotrophin HCT hematocrit HCV hepatitis C virus HDL high density lipoprotein cholesterol H & E hematoxylin & eosin HGB hemoglobin HHV8 human herpes virus 8 HIPAA Health Insurance Portability and Accountability Act HIV human immunodeficiency virus HLA human leukocyte antigen HMO health maintenance organization HPLC high performance liquid chromatography HPV human papillomavirus HSIL high grade squamous intraepithelial lesion HSV herpes simplex virus ICD International Classification of Diseases ICD-10 international classification of diseases version 10 ICU intensive care unit IgA etc. immunoglobulin A, D, E, G, M IHC immunohistochemistry INR international normalized ratio IT information technology ITP immune thrombocytopenic purpura IUD intrauterine device

IV intravenous JPEG joint photographic experts group K2 EDTA K2 ethylenediaminetetraacetic acid LCA leukocyte common antigen LDH lactate dehydrogenase LDL low density lipoprotein cholesterol LEEP loop electrocautery excision procedure LEF1 lymphoid enhancer binding factor 1 LFB luxol fast blue LIS laboratory information system LSIL low grade squamous intraepithelial lesion MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MALT mucosa-associated lymphoid tissue MCH mean corpuscular hemoglobin MCHC mean corpuscular hemoglobin concentration MCV mean corpuscular volume MDMA methylenedioxymethamphetamine (Ecstacy) MDS myelodysplastic syndrome MEN multiple endocrine neoplasia MIC minimal inhibitory concentration MLL (KMT2A) mixed lineage leukemia MPO myeloperoxidase MRI magnetic resonance imaging mRNA messenger ribonucleic acid MUM-1 Multiple Myeloma Oncogene 1 MVC motor vehicle collision N/C ratio nuclear cytoplasmic ratio NK natural killer NOS not otherwise specified NPM1 nucleophosmin gene NUT nuclear in testis OSHA Occupational Safety and Health Administration OTC over the counter panCK pancytokeratin PAS periodic acid Schiff PCR polymerase chain reaction PDF portable document format PEComa perivascular epithelioid cell PET positron emission tomography Ph’ chromosome Philadelphia chromosome PICU pediatric intensive care unit PIN prostatic intraepithelial neoplasia PLAG1 pleomorphic adenoma gene 1 PLAP placental alkaline phosphatase PLT platelet PNET primitive neuroectodermal tumor PNH paroxysmal nocturnal hemoglobinuria PO per oral POC point of care PPD test purified protein derivative PR progesterone receptor PSA prostate specific antigen PT prothrombin time PTAH phosphotungstic acid hematoxylin PTH parathyroid hormone

PTSD post-traumatic stress disorder QA quality assurance QC quality control RBC red blood cell RCC renal cell carcinoma (where appropriate) RDW red cell distribution width RhIG Rh immune globulin RNA ribonucleic acid RPM revolutions per minute RPR rapid plasma reagin RSV respiratory syncytial virus SD standard deviation SLL small lymphocytic lymphoma SMA smooth muscle actin SNOMED Systemized Nomenclature of Medicine SS-A/Ro Anti-SSA autoantibodies SS-B/La Anti-SSB autoantibodies STR short tandem repeat SWOT strengths, weaknesses, opportunities, threats TAH total abdominal hysterectomy TAT turn around time TB tuberculosis TdT terminal deoxynucleotidyl transferase THC Tetrahydrocannabinol TIA1 T cell intracellular antigen 1 TIBC total iron binding capacity TIFF Tagged Image File Format TRALI transfusion related acute lung injury TSH thyroid stimulating hormone TTF-1 thyroid transcription factor TTP thrombotic thrombocytopenic purpura TUR transurethral resection VACTERL vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities VDRL venereal disease research laboratory test VLDL very low density lipoprotein cholesterol VMA vanillylmandelic acid VSD ventricular septal defect VWF von Willebrand factor WBC white blood cell/count WHO World Health Organization WT1 Wilms tumor associated antigen

Compilation of all TDAC abbreviations – 11/2/2017 25I-NBOMe derivative of the phenethylamine hallucinogen 2C-I (N-bomb, Smiles, 25I, 25C, 25B) ACE inhibitors angiotensin converting enzyme inhibitors aCGH array comparative genomic hybridization ACGME Accreditation Council for Graduate Medical Education ACLS advanced cardiovascular life support ACO accountable care organization ACTH adrenocorticotrophic hormone ADAMTS13 a disintegrin & metalloprotease with a thrombospondin type 1 motif, member 13 ADH arginine dihydrolase (SS only) ADP adenosine diphosphate AFB acid-fast bacilli AFP alpha fetoprotein AGC atypical glandular cells AHF antihemophilia factor AHG antihuman globulin AIDS acquired immunodeficiency syndrome AIS adenocarcinoma in situ AJCC American Joint Commission on Cancer ALK anaplastic lymphoma kinase ALL acute lymphoblastic leukemia ALS amyotrophic lateral sclerosis ALT alanine aminotransferase ALTS ASCUS/LSIL triage study AML acute myeloid leukemia ANA antinuclear antibody ANCA anti-neutrophil cytoplasmic autoantibody aPTT activated partial thromboplastin time ARDS acute respiratory distress syndrome ASAP as soon as possible ASCCP American Society for Colposcopy and Cervical Pathology ASCII American Standard Code for Information Interchange ASCO American Society of Clinical Oncology ASC-H atypical squamous cells, cannot rule out high grade squamous intraepithelial lesion ASC-US atypical squamous cell of undetermined significance AST aspartate aminotransferase ATA American Thyroid Association ATHENA addressing the need for advanced HPV diagnostics ATP adenosine triphosphate ATRX alpha thalassemia/mental retardation syndrome X-linked AUS/FLUS atypia of undetermined significance/follicular lesion of undetermined significance AV atrial ventricular AVM arteriovenous malformation BAC baculovirus array BAL bronchoalveolar lavage BCG Bacillus Calmette-Guérin (therapy changes or vaccine) BCYE buffered charcoal yeast extract Beta-HCG beta-human chorionic gonadotropin BMT bone marrow transplant BNP B-type natriuretic peptide BSO bilateral salpingo-oophorectomy CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy CAIX carbonic anhydrase IX CAMP Christie-Atkins-Munch-Petersen test CAP College of American Pathologists CBC complete blood count CD cluster designation CDC Centers for Disease Control CEA carcinoembryonic antigen

CGH comparative genomic hybridization CHARGE syndrome coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness CK cytokeratin CK-MB creatine kinase-muscle or brain type CLIA Clinical Laboratory Improvements Amendments CLL chronic lymphocytic leukemia CLSI Clinical Laboratory Standards Institute CML chronic myelogenous leukemia CMS Center for Medicare and Medicaid Services CMV cytomegalovirus CNA colistin nalidixic acid CNS central nervous system CONSORT consolidated standards of reporting trials COPD chronic obstructive pulmonary disease CpG CpG (?) islands CPOE computerized provider order entry CPR cardiovascular resuscitation CPT Current Procedural Terminology CSF cerebrospinal fluid or colony-stimulating factor CT computed tomography CV coefficient of variation CXR chest x-ray DAT direct antiglobulin test DCIS ductal carcinoma in situ DDAVP 1-desamino-8-D-arginine vasopressin (desmopressin) DICOM Digital Imaging and Communications in Medicine D-MORT Disaster Mortuary Operational Response Teams DNA deoxyribonucleic acid DNMT3A DNA methyltransferase 3 alpha DRG diagnosis related group DVT deep vein thrombosis EBER EBV-encoded RNA EBUS endobronchial ultrasound EBV Epstein-Barr virus ED emergency department EDTA ethylenediaminetetraacetic acid EEG electroencephalogram EGFR epidermal growth factor receptor EIA enzyme immunoassay EKG echocardiogram ELISA elisa assay EM electron microscopy EMA epithelial membrane antigen EMG electromyograph EMR electronic medical record – do not use EHR and change old questions individually, as warranted EPA environmental protection agency EPO erythropoietin ER estrogen receptor ERCP endoscopic retrograde choledochopancreatic duodenography ERG Electroretinography or Ergosterol ESR erythrocyte sedimentation rate EUS endoscopic ultrasound EVG elastic van Gieson 5FU fluorouracil FDA Food & Drug Administration FDG-PET fluoro-deoxyglucose positron emission tomography

FISH fluorescent in-situ hybridization FFP fresh frozen plasma FLI1 Friend leukemia integration 1 transcription factor FNA fine needle aspiration FTE full-time equivalent G6PD glucose-6-phosphate dehydrogenase deficiency GATA3 guanine adenine thymine adenine transcription factor 3 G-CSF granulocyte colony stimulating factor GFAP glial fibrillary acidic protein GI gastrointestinal GIST gastrointestinal stromal tumor GM-CSF granulocyte-macrophage colony-stimulating factor GMS Gomori (or Grocott) methenamine silver GVHD graft vs. host disease H1 & H2 histamine 1 & 2 HAART highly active antiretroviral therapy HACEK Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella Hb or HgbX etc. hemoglobin A1c, C, D, E, F, S, etc. HBV hepatitis B virus HCC hepatocellular carcinoma hCG human chorionic gonatotrophin HCT hematocrit HCV hepatitis C virus HDFN hemolytic disease of the fetus and newborn HDL high density lipoprotein cholesterol H & E hematoxylin & eosin Hep Par-1 hepatocyte paraffin-1 HGB hemoglobin HHV human herpes virus HHV8 human herpes virus 8 Hib Haemophilus influenzae, serotype b HIPAA Health Insurance Portability and Accountability Act HIS hospital information system HIV human immunodeficiency virus HL7 Health Level 7 HLA human leukocyte antigen HMO health maintenance organization HPA human platelet antigen HPC hematopoietic progenitor cell hpf high power field HPLC high performance liquid chromatography HPV human papillomavirus HSIL high grade squamous intraepithelial lesion HSV herpes simplex virus HTLV human T-lymphotropic virus HTML hypertext markup language HTTP hypertext transfer protocol HUS hemolytic uremic syndrome ICD International Classification of Diseases ICD-10 international classification of diseases version 10 ICU intensive care unit IDL intermediate density lipoprotein cholesterol IgA etc. immunoglobulin A, D, E, G, M IGRA interferon gamma release assay IHC immunohistochemistry IL-1 etc. interleukin 1 INR international normalized ratio IPEX immunodysregulation polyendocrinopathy enteropathy x-linked syndrome

IPMN intraductal papillary mucinous neoplasm IRB institutional review board ISBT 128 international standard based on the Code 128 Barcode for the transfer of information associated with blood transfusion, cellular therapy and tissue transplantation IT information technology ITP immune thrombocytopenic purpura IUD intrauterine device IV intravenous IVDA intravenous drug abuser IVIG intravenous immune globulin JPEG joint photographic experts group K2 EDTA K2 ethylenediaminetetraacetic acid LCA leukocyte common antigen LC-MS/MS liquid chromatography tandem mass spectrometry LD lactate dehydrogenase LDC lysine decarboxylase test (SS only) LDH lactate dehydrogenase LDL low density lipoprotein cholesterol LEEP loop electrocautery excision procedure LEF1 lymphoid enhancer binding factor 1 LEOPARD Lentigines, EKG abnormality, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retarded growth, Deafness (congenital syndrome) LFB luxol fast blue LIS laboratory information system LISS low ionic strength solution LMP last menstrual period LOH loss of heterozygosity LOINC Logical Observation Identifiers Names and Codes LSIL low grade squamous intraepithelial lesion MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MALT mucosa-associated lymphoid tissue MASC mammillary analogue secretory carcinoma MCH mean corpuscular hemoglobin MCHC mean corpuscular hemoglobin concentration MCV mean corpuscular volume MDMA methylenedioxymethamphetamine (Ecstacy) MDS myelodysplastic syndrome MDS/MPN myelodysplastic/myeloproliferative neoplasms MEN multiple endocrine neoplasia MGUS monoclonal gammopathy of undetermined significance MIC minimal inhibitory concentration MiTF Microphthalmia Transcription Factor MLL (KMT2A) mixed lineage leukemia MPN myeloproliferative neoplasms MPO myeloperoxidase MRI magnetic resonance imaging mRNA messenger ribonucleic acid MUM-1 Multiple Myeloma Oncogene 1 MVC motor vehicle collision MYC myelocytomatosis NAAT nucleic acid amplification test NAME National Association of Medical Examiners NAT nucleic acid amplification test N/C ratio nuclear cytoplasmic ratio NF neurofibromatosis NGS next generation sequencing NILM negative for intraepithelial lesion or malignancy

NK natural killer NMO neuromyolitis optica NOS not otherwise specified NPM1 nucleophosmin gene NT-ProBNP N-terminal pro-B-type natriuretic peptide NUT nuclear in testis NYCLAD nylon clad bullet ODC ornithine decarboxylase (SS only) ONPG 2-Nitrophenyl-β-D-galactopyranoside OSHA Occupational Safety and Health Administration OTC over the counter PAMG-1 placental alpha microglobulin-1 panCK pancytokeratin panNET pancreatic neuroendocrine tumor PAS periodic acid Schiff PCR polymerase chain reaction PDF portable document format PEComa perivascular epithelioid cell PEG polyethylene glycol PET positron emission tomography Ph’ chromosome Philadelphia chromosome PHI protected health information PICU pediatric intensive care unit PIN prostatic intraepithelial neoplasia PLAG1 pleomorphic adenoma gene 1 PLAP placental alkaline phosphatase PLEVA pityriasis lichenoides et variolaformis acuta PLT platelet PMF primary myelofibrosis PNET primitive neuroectodermal tumor PNH paroxysmal nocturnal hemoglobinuria PO per oral POC point of care PPD test purified protein derivative PR progesterone receptor PSA prostate specific antigen PSMA prostate specific membrane antigen PTSD post-traumatic stress disorder PT prothrombin time PTAH phosphotungstic acid hematoxylin PTH parathyroid hormone PTH parathormone PT/INR prothrombin time/international normalized ratio PTLD post-transplant lymphoproliferative disorders PYR pyrrolidonyl amidase reactivity QA quality assurance QC quality control RAEB refractory anemia with excess blasts RARS refractory anemia with ring sideroblasts RBC red blood cell RCC renal cell carcinoma (where appropriate) RDW red cell distribution width RFP request for proposal RhIG Rh immune globulin RNA ribonucleic acid ROC receiver operator curve RPM revolutions per minute RPR rapid plasma reagin

rRNA ribosomal ribonucleic acid RSV respiratory syncytial virus RT-PCR reverse transcriptase polymerase chain reaction SBA sheep blood agar (SS only) SD standard deviation SLL small lymphocytic lymphoma SMA smooth muscle actin SNOMED Systemized Nomenclature of Medicine SNP single nucleotide polymorphism SPECT single photon emission tomography SS-A/Ro Anti-SSA autoantibodies SS-B/La Anti-SSB autoantibodies STAT from the Latin word statum, meaning 'immediately' STR short tandem repeat SWOT strengths, weaknesses, opportunities, threats TACO transfusion associated circulatory overload TAH total abdominal hysterectomy TAT turn around time TB tuberculosis TCBS agar thiosulfate-citrate-bile salts-sucrose agar TCR T cell receptor TdT terminal deoxynucleotidyl transferase THC Tetrahydrocannabinol TIA1 T cell intracellular antigen 1 TIBC total iron binding capacity TIFF Tagged Image File Format TJC The Joint Commission

TNF- tumor necrosis factor alpha TORCH (T)oxoplasmosis, (O)ther agents, (R)ubella, (C)ytomegalovirus, and (H)erpes simplex TPPA treponema pallidum agglutination assay TRALI transfusion related acute lung injury TSH thyroid stimulating hormone TTF-1 thyroid transcription factor TTP thrombotic thrombocytopenic purpura TUR transurethral resection VACTERL vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities VDRL venereal disease research laboratory test VHL Von Hippel-Lindau VIPoma vasoactive intestinal polypeptide VLDL very low density lipoprotein cholesterol VMA vanillylmandelic acid VPN virtual private network VSD ventricular septal defect VWF von Willebrand factor VZV varicella zoster virus WAGR Wilms tumour, aniridia, genitourinary anomalies, and retardation WBC white blood cell/count WHO World Health Organization WT1 Wilms tumor associated antigen

TDAC NOTES AP Down the road, Wegener granulomatosis should be changed to granulomatosis with polyangiitis. There is no dash in “S100 protein”. PNET now Ewing sarcoma – 1/2016 Granulocytic sarcoma now myeloid sarcoma – 1/2016 Chem Change “autoanalyzer” to “chemistry analyzer” Enzyme units are always U/L and hormones and proteins of unknown molecular weight are IU/L. Cyto Pap test – should be - liquid-based cervical cytology (don’t summarily change old questions) Anal Pap – should be - liquid-based anal cytology For Pap or GYN questions, the stem should now read “The most likely interpretation is”. All GYN questions that have “recommended follow-up” should include “most recent ASCCP guidelines”. 2007 NCI Thyroid Conference = National Cancer Institute Thyroid FNA State of the Science Conf. This is now changed to “The Bethesda System for Reporting Thyroid Cytopathology”. MFH – now – pleomorphic undifferentiated sarcoma Metastatic goblet cell carcinoid tumor – now- metastatic mixed adenoneuroendocrine carcinoma DP “follicular lymphoma” not “follicle cell lymphoma” according to WHO FP “TASER” should be changed to electronic control device. M & I Per the 2014 TDAC, TJC will no longer be used as an abbreviation for The Joint Commission. It will be referred to as Joint Commission, with no abbreviation. MMB When referring to the Gram stain, it should be capitalized. When referring to the gram reactivity of an organism, gram-negative or positive, it is not capitalized. MGP Fusion genes will be noted with a slash not a dash. ABL is now ABL1. Next generation sequencing (not high-throughput or massively parallel). Chromosomal microarray, not chromosome microarray NP Immunoreactive “to” not “for”. EM only for nerve and muscle and selected diseases in which EM is required. Pedi If a syndrome is named after a patient, there is an apostrophe – Lou Gehrig’s disease. If it is named after the doctor, there is no apostrophe.