Test items for licensing examination Krok 1 PHARMACY · D. Exoderm E. Mesoderm 19. The Mohr method is used to determi-ne sodium chloride mass concentration in isotonic solution. Titration

MINISTRY OF PUBLIC HEALTH OF UKRAINE

Department of human resources policy, education and science

Testing Board

Test items for licensing examination

Krok 1

PHARMACY

(російськомовний варіант)

Student ID Last name

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Authors of items: Abramov A.V., Aleksandrova K.V., Andronov D.Yu., Bilyk O.V., Blinder O.O.,

Bobyr V.V., Bobrovska O.A., Bohatyriova O.V., Bodnarchuk O.V., Boieva S.S., Bolokhovska T.O.,

Bondarenko Yu.I., Bratenko M.K., Buchko O.V., Cherneha H.V., Davydova N.V., Deriuhina L.I.,

Didenko N.O., Dmytriv A.M., Doroshkevych I.O., Dutka N.M., Dynnyk K.V., Filipova L.O.,

Havryliuk I.M., Herhel T.M., Hlushkova O.M., Hozhdzinsky S.M., Hrekova T.A., Hrechana O.V.,

Hruzevsky O.A., Hudyvok Ya.S., Hurmak I.S., Ivanets L.M., Ivanov Ye.I., Kartashova T.V., Kava T.V.,

Kazakova V.V., Kazmirchuk H.V., Kernychna I.Z., Khlus K.M., Khmelnykova L.I., Klebansky Ye.O.,

Klopotsky H.A., Klymniuk S.I., Kobylinska L.I., Koldunov V.V., Kolesnyk V.P., Kolesnikova T.O.,

Komlevoy O.M., Kononenko N.M., Kornijevsky Yu.Y., Kremenska L.V., Krushynska T.Yu.,

Kryzhanovska A.V., Kryshtal M.V., Kukurychkin Ye.R., Kuznietsova N.L., Kuzmina A.V., Lisnycha A.M.,

Lychko V.H., Makats Ye.F., Maly V.V., Matvijenko A.H., Menchuk K.M., Minarchenko V.M.,

Mikheiev A.O., Mishchenko K.M., Monatko K.V., Mruh V.M., Mylnikova O.O., Mykhailova I.V.,

Naida L.Ya., Nikitin O.V., Nikitina O.O., Novobranova O.V., Nykytiuk H.P., Osipenko L.K.,

Osiychuk O.V., Podpletnia O.A., Potikha N.Ya., Pyda V.P., Reva T.D., Rohovy Yu.Ye., Rohovyk V.Y.,

Romanenko M.I., Rotar D.V., Rovinsky O.O., Ryzhenko I.M., Sahaidak Ye.V., Salata O.V.,

Savustianenko A.V., Savchenko L.H., Seniutovych N.R., Sidelnikova T.A., Sira L.M., Skliarov O.Ya.,

Smoliakova H.N., Stetskiv A.O., Stoletov Yu.B, Streltsova N.Yu., Strilets L.M., Struchaieva H.I.,

Strumenska O.M., Surova N.A., Sviechnikova O.M., Sydorenko O.L., Tashchuk K.H., Tiupka T.I.,

Tokaryk H.V., Trzhetsynsky S.D., Tvorko M.S., Ulizko I.V., Usynsky R.S., Varynsky B.O., Vasiuk S.O.,

Vasylieva A.H., Vedernykova I.O., Vlasenko O.V., Vronska L.V., Shatova O.P., Shemonaieva K.F.,

Sheveliova N.Yu., Shevtsova A.I., Shkoda O.S., Shono N.A., Shtryhol S.Yu., Shumeiko O.V., Shvets V.M.,

Shyrykalova A.O., Yahupova A.S., Yaremiy I.M., Yashchyshyn Z.M., Yushchenko T.I., Zadorina O.V.,

Zahrychuk H.Ya., Zarechensky M.A., Zhylinska K.I. and Committees of professional expertise.

Item reviewers. Anisimova V.YU., Arzumanov P.S., Bocharov O.A., Cherpak O.M., Deineka C.YE.,

Herush O.V., Holdobina O.V., Hontova T.M., Hrihor’yeva N.P., Ivanec L.M., Kaluhina S.M.,

Kaplaushenko A.H., Klepa T.I., Kobilinska L.I., Kostina T.A., Lisnicha A.M., Lyubinec L.A., Macoid O.B.,

Minarchenko V.M., Ohurcov V.V., Pocrishko O.V., Shanaida M.I., Shtrihol S.YU., Томаrovska Т.О.,

Tyupka Т.І., Vasuk S.O., Vronska L.V., Yuschenko Т.І., Zahaiko A.L., Zahrichuk H.YA.,

The book includes test items for use at licensing integrated examination “Krok 1. Pharmacy” and

further use in teaching.

The book has been developed for students of pharmaceutical faculties and academic staff of higher

medical educational establishments.

Approved by Ministry of Public Health of Ukraine as examination and teaching

publication based on expert conclusions (Orders of MPH of Ukraine of

14.08.1998 №251, of 27.12.1999 №303, of 16.10.2002 №374, of 29.05.2003 №233).

© Copyright Testing Board.

General Instruction

Every one of these numbered questions or unfinished statements in

this chapter corresponds to answers or statements endings. Choose the

answer (finished statements) that fits best and fill in the circle with the

corresponding Latin letter on the answer sheet.

Krok 1 Pharmacy 2015 1

1. Calculation of thermal effects ofchemical reactions at pharmaceuticalproduction is based on the Hess law stati-ng, that reaction thermal effect is determi-ned by:

A. Initial and final state of systemB. Mechanism by which the chemicalchange occursC. Route by which the chemical changeoccursD. Number of intermediate stagesE. Process duration

2. A victim of a traffic accident is hospi-talized at a resuscitation unit. Objectively:the patient is unconscious, BP is 90/60 mmHg, high blood content of creatinine andurea is observed, diurnal diuresis is 80 ml.Characterize the patient’s diurnal diuresis:

A. AnuriaB. OliguriaC. PolyuriaD. PollakiuriaE. Nocturia

3. In snake venom there is a substancethat causes erythrocyte hemolysis whenit is introduced into a human organi-sm. Blood test revealed a large amountof lysolecithin (lysophosphatidylcholi-ne). What enzyme leads to accumulatinglysolecithin in blood?

A. Phospholipase A2B. Phospholipase A1C. Phospholipase CD. Phospholipase DE. Neuraminidase

4. Microbe survial in environment is faci-litated by spore formation. What mi-croorganisms of those listed below arespore formers:

A. ClostridiumB. BacteroidesC. StaphylococcusD. PeptococcusE. Peptostreptococcus

5. Bacteria rapidly become resistantto drugs in the course of antibacterialtreatment. What structural components ofbacteria provide for their resistance?

A. R-plasmidsB. SporesC. CapsuleD. FlagellaE. Volutine granules

6. If aqueous solutions of the drugs listed

below are all of the same molarity, the hi-ghest boiling temperature will belong to:

A. Sodium sulfateB. Promedol (Trimeperidine)C. NicotinamideD. ResorcinE. Iodine

7. Which of these formulas corresponds wi-th acetoacetic acid?

A.

B.

C.

D.

E.

8. Universal system of biological oxidati-on of nonpolar compounds (numerousdrugs, toxic agents, steroid hormones,cholesterol) is microsomal oxidation.Name the cytochrome that is included inoxygenase chain of microsomes:

A. Cytochrome Р-450B. Cytochrome CC. Cytochrome A3D. Cytochrome AE. Cytochrome C1

9. A patient with chronic constipation hadbeen prescribed bisacodyl. After 3 weeksof treatment, the patient noticed a reducti-on of laxative effect. This is caused by thedevelopment of the following side-effect:

A. ToleranceB. DependenceC. SensibilizationD. CumulationE. Dysbacteriosis

10. A newborn child born from Rh-negative mother in the result of her thi-rd pregnancy presents with graduallyworsening jaundice, irritated centralnervous system, anemia. What type ofjaundice does the infant suffer from?


A. HemolyticB. HepatocellularC. ObstructiveD. ParasiticE. Toxic

11. Structure of proteins includes protei-nogenic amino acids. What is the positionof the amino group in the structure of theseamino acids?

A. α-positionB. β-positionC. γ-positionD. δ-positionE. ε-position

12. In an emergency situation a scuba di-ver has quickly risen from the depths tothe surface, thus breaking safety rules. Heis unconscious, presents with respiratoryfailure and cardiac activity disorder as theresult of decompression sickness. Whatcomplication may develop in the scuba di-ver?

A. Gas embolismB. Fat embolismC. Air embolismD. Cellular embolismE. Thromboembolism

13. The patient has been hospitalised withpneumonia. What kind of respiratory fai-lure does the patient have?

A. RestrictiveB. ObstructiveC. CentralD. PeripheralE. Thoracic diaphragm

14. Thermodynamic calculations allowus to determine the possibility and di-rection of spontaneous processes. In anisolated system the change of the followi-ng thermodynamic function is used for thispurpose:

A. EntropyB. Gibbs energyC. Helmholtz energyD. Internal energyE. Enthalpy

15. Organisms of plants and animalsbelong to biological systems that performsubstance and energy exchange with theirenvironment. These systems are:

A. Open, heterogeneousB. Isolated, heterogeneousC. Closed, homogeneousD. Closed, heterogeneousE. Open, homogeneous

16. What drug should be administered forindividual prevention of malaria?

A. ChingaminB. RifampicinC. AmpicillinD. GentamicinE. Biseptol (Co-Trimoxazolel)

17. A sample section of an axial body showsa complex consisting of phellogen and itsderivatives - cork and phelloderm. This ti-ssue is called:

A. PeridermB. ColenchymaC. SclerenchymaD. EpiblemaE. Epidermis

18. When root was being studied under mi-croscope, root hairs were detected, whichare cell growths of:

A. EpiblemaB. EpidermisC. EndodermD. ExodermE. Mesoderm

19. The Mohr method is used to determi-ne sodium chloride mass concentration inisotonic solution. Titration is carried outwith the following indicator present:

A. Potassium chromateB. FluoresceinC. Ammonium iron (III) sulfateD. DiphenylcarbazoneE. Ferroin

20. Choose the pair of electrodes forpotentiometric pH measurement of asolution:

A. Glass and silver chlorideB. Calomel and silver chlorideC. Quinhydrone and antimonialD. Mercury sulphate and silver chlorideE. Glass and antimonial

21. What disorder of local circulation ischaracterized by pallor, local temperaturedrop, pain, local sensitivity disorder,reduction of the organ volume?


A. IschemiaB. VenostasisC. ThrombosisD. EmbolismE. Arterial hyperemia

22. Racemose clusters of calciumcarbonate crystals are detected amongthe waste products of a protoplast. Thesecrystals are:

A. CystolithsB. Isolated crystalsC. RaphidesD. StyloidsE. Druses

23. Heart rate of a person at rest is 40/min.What structure is the pacemaker of heartin this man?

A. Atrioventricular nodeB. Sinoatrial nodeC. His’ bundleD. His’ bundle branchesE. Purkinje fibers

24. The volume of air exhaled by ahealthy person during quiet breathing wasmeasured with a spirometer and determi-ned to be 0,5 liter. What is this volumecalled?

A. Tidal volumeB. Inspiratory reserve volumeC. Expiratory reserve volumeD. Vital capacity of lungsE. Residual volume

25. A patient has been taking diclofenacsodium for a long time. A family physi-cian withdrew this drug and prescribedcelecoxib. What disease was the cause ofdrug substitution?

A. Peptic ulcerB. Bronchial asthmaC. UrolithiasisD. Arterial hypertensionE. Chronic hepatitis

26. Specify the standard solution (titrant)for the iodometric determination of oxi-dants:

A. Na2S2O3B. KMnO4C. I2D. K2Cr2O7E. KBrO3

27. In the qualitative analysis whichinvolves precipitation of sulphates of thethird analytical group cations (Ca2+, Sr2+,

Ba2+) the solubility of sulphates can bereduced by adding:

A. Ethyl alcoholB. Distilled waterC. BenzeneD. ChloroformE. Amyl alcohol

28. In a surgical unit an outbreakof purulent infections has been regi-stered. The infections are caused byStaphylococcus aureus with multiple resi-stance to antibiotics. What plasmid hasprovided this property?

A. RB. FC. ColD. ToxE. Hly

29. What standard solution (titrant) is usedin Folgard’s direct titration method?

A. Ammonium thiocyanateB. Sodium chlorideC. Silver nitrateD. Potassium chromateE. Potassium dichromate

30. Uric acid is a derivative of:

A. PurineB. IndoleC. PyrazineD. PyrazoleE. Pyridine

31. Select structural isomers among the gi-ven compound pairs:


A.

B.

C.

D.

E.

32. Optical activity of monosaccharidescan be explained by their:

A. Asymmetric carbon atoms in a moleculeB. Asymmetric crystalC. Complicated rotation around σ-bondD. Aldehyde or ketone groupE. Number of hydroxyl groups in amolecule

33. Name the disaccharide with thefollowing structure:

A. β-lactoseB. α-lactoseC. β-maltoseD. β-cellobioseE. Saccharose

34. Which of the ligands is bidentate?

A. EthylenediamineB. Thiocyanate ionC. Cyanide ionD. PyridineE. Hydroxide ion

35. Combined administration of furosemi-de with aminoglycoside antibiotics causes:

A. Hearing impairmentB. Increased blood pressureC. CrampsD. HyperhidrosisE. Increased intraocular pressure

36. In terms of water-air interface, thefollowing substance acts as a surface-activesubstance:

A. Valeric acidB. HClC. NaOHD. UreaE. -

37. At the sixth month of pregnancya woman has been diagnosed withsevere iron-deficiency anemia. Diagnosticcharacter was the appearance of thefollowing in blood:

A. Hypochromic erythrocytesB. MacrocytesC. MegalocytesD. ReticulocytesE. Erythroblasts

38. Nitrite ions in presence of nitrate ionscan be detected by means of:

A. Crystalline antipyrine in presence ofdilute HClB. Crystalline sodium thiosulfateC. DimethylglyoximeD. Crystalline iron (III) sulfateE. Diphenylcarbazone

39. Choose the colloid surfactant amongthe substances listed below:

A. Potassium oleateB. IodineC. Sodium chlorideD. PolyethyleneE. Gelatin

40. Analysis of the cerebrospinal fluid ofa child with signs of purulent lesion ofbrain tunics revealed gram-negative bean-shaped diplococci. What provisional di-agnosis can be made on the basis of theanalysis results?

A. MeningitisB. GonorrheaC. CholeraD. PlagueE. Anthrax

41. Given the ability of iodine to dissolvein nonpolar solvents, determine the typeof chemical bond in an I2 molecule:

A. Nonpolar covalentB. IonicC. Polar covalentD. MetalE. Intermolecular interaction

42. What product results from propionic


aldehyde and PCl5 interaction?

A.

B.

C.

D.

E.

43. Which of these reactions can be used toidentify the primary amino group?

A.

B.

C.

D.

E.

44. In the course of long-term treatment of

an infectious patient with penicillin, thepathogen transformed into the L-form.What changes occur in the pathogen cellin case of L-transformation?

A. Absence of a cell wallB. Absence of flagellaC. Absence of a capsuleD. Absence of a sporeE. Absence of inclusions

45. Interaction of aniline with brominewater resulted in white precipitate. Whatsubstance was produced?

A.

B.

C.

D.

E.

46. During feces analysis of a 3-month-old child with signs of enteric infection,numerous dark-red colonies has grown onEndo agar. What microorganisms can bethe cause of such enteric infection?

A. EscherichiaB. StreptococciC. GonococciD. SalmonellaeE. Shigella

47. During assessment of air purity in anaseptic unit of a phamacy, sedimentationanalysis had been applied. Test resultedin growth of the small colonies with areasof hemolysis. What medium was used forinoculation?


A. Blood agarB. Levine’s formulation (Eosin MethyleneBlue agar)C. Endo agarD. Ploskirev’s agarE. Egg-yolk salt agar

48. What enzyme allows for synthesysof various genes from template-RNA toDNA in genetic engineering (this enzymecatalyzes the process detected in RNA-viruses)?

A. Reverse transcriptaseB. ExonucleaseC. DNA-ligaseD. HelicaseE. Endonuclease

49. According to van’t Hoff rule, when thetemperature is raised by 10 degrees, thereaction rate increases by:

A. 2-4 timesB. 1,5 timesC. 5 timesD. 10 timesE. Temperature does not affect reaction rate

50. What anions form brown ring with iron(II) salts in the presence of concentratedsulfuric acid?

A. Nitrate ionsB. Acetate ionsC. Bromate ionsD. Citrate ionsE. Thiocyanate ions

51. Specify the precipitating agent to beused in gravimetric determination of calci-um salts:

A. (NH4)2C2O4B. K2C2O4C. Na2C2O4D. Na2CO3E. K2CO3

52. Chromatin contains positively chargedhistone proteins. What amino acid iscontained in histone proteins in largeamounts?

A. LysineB. AlanineC. ValineD. ThreonineE. Serine

53. Diet of a human must contain vitami-ns. What vitamin is usually prescribed fortreatment and prevention of pellagra?

A. Vitamin PPB. Vitamin CC. Vitamin AD. Vitamin B1E. Vitamin D

54. After application of chlorine-zinc-iodine to the thick colourless cellmembranes of collenchyme they becameviolet. That means the membranes are:

A. CelluloseB. LignificatedC. CutinizedD. MineralizedE. Suberinized

55. Calomel electrode is listed in the StatePharmacopoeia of Ukraine as auxiliaryelectrode for pH measurement. What typeof electrodes is it?

A. Second kindB. First kindC. GasD. RedoxE. Ion-selective

56. Specify the name of the compoundaccording to the IUPAC nomenclature:

A. 2,3,5-Trimethyl heptadiene-3,4B. 3,5,6,6-Tetramethyl heptadiene-3,4C. 3,5,6,6-Trimethyl hepten-3D. 2-Ethyl-4,5-dimethyl hexadiene-2,3E. 2-Ethyl-4,5,5-trimethyl pentadiene-2,3

57. Thiocyanatometric titration methodrequires secondary standard solution ofpotassium thiocyanate that is standardizedwith standard solution of:

A. Silver nitrateB. Hydrochloric acidC. Sulfuric acidD. Iron (II) sulfateE. Copper (II) nitrate

58. To identify a drug by thin-layerchromatography the following parameteris used:


A. RfB. nC. E, mVD. I , AE. Kp

59. A 22-year-old man was stung by bees;the affected area became hyperemic andedematous. What is the leading mechani-sm of edema development in this patient?

A. Increased permeability of the capillariesB. Decreased hydrostatic blood pressure inthe capillariesC. Increased oncotic pressure of tissue fluidD. Impaired lymphatic effluxE. Reduced oncotic pressure of blood

60. A patient has obstruction of thecommon bile duct. Which of thesesubstances is usually found in urine in suchcases?

A. BilirubinB. Ketone bodiesC. Uric acidD. CreatinineE. Glucose

61. A student analyzes an axial plantorgan characterized by radial symmetry,unlimited growth, positive geotropism. Itprovides nutrition, vegetative propagation,anchorage of plant in the soil. This organcan be identified as:

A. RootB. StemC. LeafD. RhizomeE. Seed

62. Choose the name that corresponds wi-th the formula: CH3 − C ≡ N :

A. Acetic acid nitrileB. AcetamideC. Acetic anhydrydeD. AcetoximeE. Ethyl isocyanide

63. A patient with systemic lupuserythematosus has developed diffuseaffection of kidneys followed by protei-nuria, hypoproteinemia, extensive swelli-ng. What mechanism of proteinuriadevelopment is the most likely in this case?

A. Autoimmune disorder of the nephronglomerulusB. Inflammatory disorder of the nephrontubuleC. Ishemic disorder of the nephron tubuleD. Increased concentration of blood protei-nsE. Disorder of the urinary tracts

64. To determine sodium iodide withFajans method the following indicator isrequired:

A. EosinB. Methyl-orangeC. DiphenylcarbazoneD. Potassium chromateE. Iron ammonium alum

65. Which of the given compounds WILLNOT decolorize bromine water?

A. CH3 − CH3B. CH2 = CH2C. CH ≡ CHD. CH3 − CH = CH2E.

66. Which of the following reactions isrequired in order to obtain an azo dye outof an aromatic amine?

A. Diazotization and azo compoundB. Reduction and diazotizationC. Diazotization and interaction withpotassium cyanideD. Salt formation and nitrationE. Alkylation and nitrosation

67. What is the mechanism of brominationof toluene methyl group?

A. SRB. AEC. SED. SNE. AN

68. Quinoline reacts with the followingreagent if heteroatom is present:


A.

B. Na2SO4C. ��D. NaNH2E. NaNO3

69. Aniline can be converted into thewater-soluble salt through its treatment wi-th the solution of:

A. Hydrochloric acidB. Sodium hydroxideC. Sodium sulfateD. EthanolE. Dimethylamine

70. Specify the reagent necessary for thefollowing transformation:

A. NH2NH2B. NH2OHC. CH3NH2D. C6H5NHNH2E. NH3

71. One of the cyclic glucose forms is asfollows:

Name this compound:

A. α-D-glucopyranoseB. β-D-glucopyranoseC. α-L-glucopyranoseD. α-D-glucofuranoseE. β-D-glucofuranose

72. Select the formula for pentene-2 fromthe list:

A. CH3 − CH2 − CH = CH − CH3B. CH3 − CH2 − CH2 − CH2 − CH3C. CH3 − CH2 − CH2 − CH = CH2D. CH3 − CH2 − CH2 − CH3E. CH3 − CH = CH − CH3

73. The study of the main root ontogenesisshows that it has developed from:

A. RadicleB. Apical meristemC. PericycleD. Lateral meristemE. Intercalary meristem

74. Silver mirror reaction can becharacterized by:

A. Production of metalB. SmellC. Red colouring of precipitateD. Blue colouring of solutionE. Decolouration

75. The end product of starch hydrolysis is:

A. D-glucoseB. D-fructoseC. SaccharoseD. MaltoseE. D-galactose

76. Specify the electronic effects of thecarboxylic group (-СООН) in a benzoicacid molecule:

A. -I, -MB. -IC. +I, -MD. +IE. -I, +M

77. Which of the alcohols given belowproduces acetone when oxidated?

A.

B.

C.

D.

E.

78. What reagent allows to simultaneouslydetect both aldehyde group and glycolfragment presence in glucose molecule?

A. Cu(OH)2B. Br2C. AlCl3D. FeCl3E. KMnO4


79. What class of organic compounds ischaracterized by the presence of C ≡ Ngroup?

A. NitrilesB. AminesC. Nitro compoundsD. AlcoholsE. Aldehydes

80. If the amount of a high-molecularsubstance added to the sol is very small,it may not increase but decrease its stabili-ty. This phenomenon is called:

A. SensibilizationB. SolubilizationC. Mutual coagulationD. Colloidal protectionE. Sol adaptation

81. Spore and pollen analysis revealedtetrahedral spores in the pollen, whi-ch have semi-circular base and reticularsurface. The spores can belong to:

A. LycopodiophytaB. EquisetiphytaC. BryophytaD. PolypodiophytaE. Pinophyta

82. In the practice of harvesting herbalraw material of Asteraceae family the term”flowers” means both individual flowersand inflorescences. However, the notion of”flowers” is botanically correct only for:

A. Centaurea cyanusB. Gnaphalium uliginosumC. Arnica montanaD. Echinops ritroE. Bidens tripartita

83. A woman noticed that a cut on herskin was still bleeding even after 20 mi-nutes had passed. What vitamin deficiencycauses such condition?

A. Vitamin KB. Vitamin AC. Vitamin DD. Vitamin EE. Vitamin B12

84. The primary structure of nucleic acidsis a polynucleotide chain that has a certaincomposition and order of the nucleotides.What bonds stabilize this structure?

A. 3’,5’-phosphodiesterB. PeptideC. GlycosidicD. DisulfideE. Amide

85. Quercus robur leaves have the followi-ng type of lamina shape and division:

A. PinnatilobateB. TrilobateC. PinnatipartiteD. PalmatilobateE. Palmatipartite

86. Microbiological purity of tableteddrugs had been tested at a factory. Samplescultivation in mannitol salt agar resultedin growth of golden-yellow colonies, mi-croscopic examination of colonies detectedgram-positive globular bacteria situatedin clusters; microorganisms had plasmacoagulation prorerties. What pure bacteri-al culture was obtained?

A. Staphylococcus aureusB. EnterobacteriaceaeC. Staphylococcus epidermidisD. Staphylococcus saprophyticusE. Pseudomonas aeruginosa

87. Leaves affected by mosaic discolorationhave been detected at medicinal plantati-ons. What microorganisms are the cause?

A. Plant-pathogenic virusesB. Plant-pathogenic bacteriaC. Plant-pathogenic fungiD. ProtozoaE. Rickettsia

88. A dry-heat box is used for sterilizationof various materials and instruments in abacteriological laboratory. This sterilizati-on method can be applied to the followingobjects:

A. Glass test tubesB. Rubber glovesC. Simple nutrient mediumD. Wire inoculating loopsE. Physiological solution

89. A 3,5-year-old child has been di-agnosed with dysbacteriosis in the formof critical reduction of gram-positiveanaerobic bacteria and increased numberof staphylococci and yeast fungi. Whatpreparation should be used for thecorrection of dysbacteriosis?


A. BifidumbacterinB. ColibacterinC. Coli-Proteus bacteriophageD. FurazolidoneE. Lactoglobulin

90. A sample of water used in drugproduction has been sent to a laboratoryfor sanitary and virological analysis.Presence of what virus group will be indi-cative of faecal contamination of water andthus the need for its additional purificati-on?

A. PicornaviridaeB. HerpesviridaeC. OrthomyxoviridaeD. RetroviridaeE. Flaviviridae

91. Specify the indicator of the protectiveproperties of high-molecular compoundsof body, which promote the retention ofcalcium, phosphate and carbonate in bloodplasma:

A. Protective valueB. Coagulation thresholdC. Critical micelle concentrationD. Hydrophilic-lipophilic balanceE. Volume of sol coagulated by 1 mol of theelectrolyte substance

92. A 40-year-old man diagnosed withgastric ulcer has developed the symptomsanew after a long period of dormancy. Suchdisease course can be characterized as a:

A. RecurrenceB. RemissionC. RecoveryD. LatencyE. Prodromal phase

93. An elderly patient exhibits low levels ofred blood cells and hemoglobin in blood,but the color index is 1,3. Blood smearanalysis revealed megaloblasts. What typeof anemia is observed in this case?

A. B12-folic acid deficiencyB. Iron-deficiencyC. Acquired hemolyticD. Hereditary hemolyticE. Chronic posthemorrhagic

94. After drinking milk a 1-year-old childhas developed diarrhea and flatulence. Thebaby is likely to have the deficiency of thefollowing enzyme:

A. LactaseB. MaltaseC. AldolaseD. HexokinaseE. Glycosidase

95. A man presents with signs of albi-nism: blonde hair, extreme photosensi-tivity, impaired vision. What amino acidmetabolism is disrupted in the patient?

A. TyrosineB. MethionineC. ProlineD. HistidineE. Valine

96. In the process of silver cations identi-fication reaction HCl and then ammoniasolution have been added to the solution.What compound has been produced as aresult?

A. [�g(N�3)2]�lB. [�g2(N�3)3]�lC. �g��D. �g�lE. [�g(N�3)3]�l

97. Microscopic study of soybean seedsstained with Sudan III revealed dropletsof various sizes. They are:

A. LipidsB. ProteinsC. StarchD. InulinE. Glycogen

98. In a chemico-analytical laboratory a di-spensing chemist studies the solution ofanion mixture. When antipyrin solution isadded to the solution, it becomes emerald-green in colour. This analytical effect signi-fies presence of the following anions:

A. NitriteB. NitrateC. AcetateD. TartrateE. Citrate

99. Selective solvents are used inlaboratories and factories to isolate andrefine essential oils, alkaloids, antibioticsand other pharmaceutical subctances. Thisprocess is called:

A. ExtractionB. SedimentationC. CoagulationD. FlocculationE. Flotation

100. Sol of iron (III) hydroxide is positi-


vely charged. Specify the ion which has thelowest coagulation threshold:

A. SO2−4

B. Cl−

C. Cu2+

D. Na+

E. J−

101. Specify the standard solutions that areused in permanganatometric titration toquantify the oxidants by the residual ti-tration method:

A. Potassium permanganate, iron (II)sulfateB. Potassium dichromate, sodium thi-osulfateC. Potassium bromate, sodium thiosulfateD. Potassium iodate, sodium thiosulfateE. Cerium (IV) sulfate, iron (II) sulfate

102. What indicator is used for fixing theendpoint of mercurimetric titration?

A. Thiocyanate complexes of iron (III)B. FluoresceinC. EosinD. MurexideE. Potassium chromate

103. Substrate-linked phosphorylationoccurs in the cycle of tricarboxylic acids.What compound takes part in this reacti-on?

A. Succinyl coenzyme AB. α-ketoglutarateC. Acetyl coenzyme AD. SuccinateE. Malate

104. The patient with alcoholic ci-rrhosis complains of general weaknessand dyspnea. The following is revealed:decrease of arterial pressure, ascites, di-lation of the superficial veins of thestomach anterior wall, esophageal vari-cose veins dilatation, splenomegaly. Whathaemodynamics disorder does the patientsuffer from?

A. Portal hypertensionB. Left ventricular failureC. Right ventricular failureD. Cardiac insufficiencyE. Collapse

105. Pharmacy has received viricides.Choose the viricide used for influenzatreatment from the list given below:

A. RimantadineB. MetisazoneC. LevamisoleD. AzidothimidineE. Acyclovir

106. Colloid silver preparationsProtargolum and Collargolum are widelyused in medical practice as bactericidaldrugs. In addition to the active ingredients,these drugs contain protein compounds.What is the function of proteins in thesepreparations?

A. Prevention of coagulation of the colloi-dal solutionB. Prolongation of shelf-lifeC. Reduction of the side effectsD. Improvement of the drug technologyE. Potentiation of the bactericidal action ofsilver

107. Mass fraction of Fe2+ ions in Mohr’ssalt can be determined by gravimetric sedi-mentation method using:

A. NH4OHB. Na2SC. K3PO4D. BaCl2E. ZnCl2

108. Silver nitrate solution has been addedto the solution containing anions of the fi-rst analytical group. It resulted in yellowprecipitate. That means the following arepresent in the solution:

A. Arsenite ionsB. Arsenate ionsC. Sulphate ionsD. Iodide ionsE. Bromide ions

109. Inhibition of the synthesis of bile aci-ds from cholesterol in liver of an experi-mental animals has caused maldigestion oflipids. What is the role of these acids in theenteral lipidic metabolism?

A. They emulsify dietary lipidsB. They keep balance of alkaline envi-ronment in the intestinesC. They participate in the synthesis of lipidsD. They are part of LDLE. They activate the formation of chylomi-crons

110. Name the above-ground sprout modi-fications that develop from lateral buds,are situated in leaf angles or inflorescences,and take part in vegetative reproduction:


A. BulbilsB. Above-ground tubersC. CladodesD. TendrilsE. Thorns

111. What type of conducting bundles ischaracteristic of all root zones in one-seeded plants?

A. RadicalB. Amphivasal (Lepto centric)C. Amphicribal (Hadro centric)D. BilateralE. Collateral

112. A patient with atherosclerosis hasbeen prescribed Linaetholum containi-ng essential fatty acids. Which of thefollowing acids is an essential part of thepreparation?

A. LinolenicB. PalmiticC. CrotonicD. StearicE. Oleic

113. The Volhard method is usedto determine sodium chloride massconcentration. Name the titrant of thismethod:

A. Ammonium thiocyanateB. Mercury (I) nitrateC. Sodium tetraborateD. Mercury (II) nitrateE. Sodium hydroxide

114. Mass fraction of pharmaceuticalpreparations that contain aromatic ami-no groups is determined through nitritetitration. What external indicator is usedin this case?

A. Starch-iodide paperB. Methylene redC. Eriochrome Black TD. PhenolphthaleinE. Eosin

115. What cation of the 4th analyticalgroup is present in a solution, if it is knownthat the reaction with a group reagentcauses formation of yellow precipitate?

A. Cr3+

B. Zn2+

C. Sn2+

D. Al3+

E. Sn(IV )

116. In response to the administrationof protein drugs, a patient developed an

allergic reaction. The development of theallergic reaction is caused by the increasedsynthesis of the following compound:

A. HistamineB. CholineC. AdrenalineD. HistidineE. Serotonin

117. The patient has icteric skin;unconjugated bilirubin content in bloodis high; conjugated bilirubin in urine is notdetected. There is significant amount ofurobilin in urine and stercobilin in feces.Name the pathology characterized by thegiven symptoms:

A. Hemolytic jaundiceB. Obstructive jaundiceC. Jaundice of the newbornD. Hepatocellular jaundiceE. Atherosclerosis

118. A patient complains of pain in thesmall joints. High concentration of uricacid is detected in his blood plasma. Whatpathology causes such changes?

A. GoutB. Diabetes mellitusC. PhenylketonuriaD. Lesch-Nyhan syndromeE. Diabetes insipidus

119. Corolla of a zygomorphichermaphroditic flower consists of 5 petals:the largest one is called the banner, the twolateral petals are called the wings, and thetwo fused petals forming the keel. Suchcorolla is characteristic of medicinal plantsof Leguminosae family. Name the type ofcorolla:

A. PapilionaceousB. LabiateC. Saucer-shapedD. FunnelformE. Tubular

120. What ions have maximal coagulativeeffect, when added into positive sols?

A. PO3−4

B. Al3+; Fe3+

C. K+; Na+

D. SO2−4

E. Cl−

121. What anion of the 2nd analytic groupproduces black precipitate with groupreagent AgNO3?


A. S2−

B. I−

C. Cl−

D. Br−

E. NCS−

122. A patient suffering from coronaryheart disease, who had had two myocardialinfarctions of left ventricular wall, presentswith bubbling breathing and dyspnea.Pulmonary auscultation reveals numerousmoist crackles. What kind of heart failureis it?

A. Left ventricularB. Right ventricularC. CompensatedD. SubcompensatedE. Combined

123. You are studying the silvery downyplant of Asteraceae family, which is rich wi-th essential oils and bitters. Harvested areapical sprouts with panicle of small roundflower heads. This plant is:

A. Artemisia absinthiumB. Arctium lappaC. Bidens tripartitaD. Calendula officinalisE. Chamomilla recutita

124. A 46-year-old patient was found tohave hyperactivity of creatine kinase in hisblood serum. What kind of pathology canbe suspected?

A. Myocardial infarctionB. Acute pancreatitisC. Chronic hepatitisD. Haemolytic anemiaE. Renal failure

125. Microcrystalloscopic reactions ofpotassium ions detection include thereaction with:

A. Sodium lead hexanitrocuprate (II)B. Sodium hydrotartrateC. Sodium hexanitrocobaltateD. Sodium tetraphenylborateE. Flame test

126. Emulsions containing less then 0,1%of dispersed phase (in volume) are classifi-ed as:

A. DilutedB. ConcentratedC. High-concentrationD. Water-in-oil typeE. Oil-in-water type

127. A student in severe condition was deli-

vered into a contagious isolation ward ofa hospital. He is diagnosed with toxic di-phtheria of the pharynx. What drug shouldbe administered immediately for specifictreatment and prevention of complicati-ons?

A. Antidiphtheric serumB. Diphtheria and tetanus toxoids andpertussis adsorbed vaccineC. Diphtheria anatoxinD. Penicillin antibioticE. -

128. Cataract (lenticular opacity) hasdeveloped in a 52-year-old woman wi-th pancreatic diabetes. What process hasintensified and thus caused lenticularopacity?

A. Protein glycosylationB. LipolysisC. KetogenesisD. Protein proteolysisE. Gluconeogenesis

129. Common nettle, hop, black elderberryare the plants that require soils rich in ni-trogen compounds, that is, such plants arecalled:

A. NitrophytesB. NitrophobesC. CalciphilesD. CalciphobesE. Halophytes

130. A man received a radiation dose of30 Gy. He presents with necrotic angi-na, disorders of the gastrointestinal tract.Blood tests revealed anemia, leukopeniaand thrombocytopenia. What period ofacute radiation sickness is observed in thepatient?

A. Height of diseaseB. Primary reactionsC. Imaginary wellbeingD. End of diseaseE. -

131. In the course of an experiment inthe mesenteric vein of a toad a trombuswas created with a crystal of common salt.What processes occurred during the firststage of trombus formation?

A. Adhesion, aggregation, agglutination ofplateletsB. Production of active thromboplastinC. Production of thrombinD. Production of fibrin monomerE. Production of fibrin polymer


132. A patient with hyperproductionof thyroid hormones has been prescri-bed Merkazolilum. This drug inhibitsthe following enzyme of iodothyroninesynthesis:

A. Iodide peroxidaseB. AromataseC. ReductaseD. DecarboxylaseE. Aminotransferase

133. Hemoglobin catabolism results inrelease of iron which is transported to thebone marrow by a certain transfer proteinand is used again for the synthesis ofhemoglobin. Specify this transfer protein:

A. Transferrin (siderophilin)B. TranscobalaminC. HaptoglobinD. CeruloplasminE. Albumin

134. For the specific prevention ofinfluenza the employees of an enterprisewere vaccinated with ”Influvac”. What typeof immunity will develop in the body ofthose vaccinated?

A. Artificial activeB. Innate congenitalC. Artificial passiveD. Natural activeE. Natural passive

135. A patient has a mental disorder dueto the insufficient synthesis of gamma-aminobutyric acid in the brain. Suchpathological changes might be caused bythe deficiency of the following vitamin:

A. PyridoxineB. TocopherolC. CyanocobalaminD. Folic acidE. Riboflavin

136. Soil microflora often contai-ns representatives of pathogenic mi-croorganisms. Specify the diseases withcausative agents that can remain viable inthe soil for a long time:

A. Tetanus and gas anaerobic infectionB. Tuberculosis and mycobacteriosesC. Colibacillosis and choleraD. Leptospirosis and plagueE. Typhoid fever and dysentery

137. The method consisting in removalof low-molecular impurities from colloi-dal systems and high-molecular compoundsolutions by semipermeable membrane di-

ffusion is called:

A. DialysisB. ElectrodialysisC. UltrafiltrationD. DecantationE. Compensatory dialysis

138. Neuroleptanalgesia has been appli-ed in the case of cardiac infarction. Whatneuroleptic is most often applied along wi-th fentanyl?

A. DroperidolB. Perphenazine (Aethaperazinum)C. LevomepromazineD. ClozapineE. Sulpiride

139. Due to prolonged taking ofphenobarbital the epileptic patient hasdeveloped tolerance for this drug. Whatis this phenomenon based on?

A. Biotransformation accelerationB. Absorption process weakeningC. Increase of receptor sensitivityD. Biotransformation suppressionE. Substance accumulation in body

140. What side effect is characteristic ofcaptopril?

A. Dry coughB. Increase of arterial pressureC. HyperglycemiaD. Cardiac rate disorderE. Hypokaliemia

141. During treatment of chronic cardi-ac failure with digitoxin a patientdeveloped the drug-specific signs of intoxi-cation. A doctor prescribed Unithiol(Dimercaptopropansulfonate sodium).Explain its mechanism of action of Unithi-ol in case of cardiac glycoside intoxication:

A. Restoration of �+-Na+-adenosinetriphosphatase activityB. Binding of calcium ionsC. Increase of sodium concentration incardiac hystiocytesD. Increase of calciun permeability ofcardiac hystiocytesE. Binding of glycosides into complexcompound

142. An elderly patient suffers from consti-pation caused by colon hypotonia. Whatdrug should be prescribed?


A. BisacodylB. Sodium sulfateC. Castor oilD. Atropine sulfateE. Novocainamide (Procainamide)

143. In the course of bronchitispharmacotherapy a patient has developeddyspeptic disorders, photodermatitis andhepatic failure. What drug can cause suchdisorders?

A. DoxycyclineB. ParacetamolC. Ascorbic acidD. AcetylcysteineE. Codeine phosphate

144. The patient with rheumatoid arthritisand concomitant duodenal ulcer has to beprescribed a nonsteroid antiinflammatorydrug. Which one of the drugs listed belowis the drug of choice in the given case?

A. CelecoxibB. Acetylsalicylic acidC. ParacetamolD. MetamizoleE. Diclofenac sodium

145. The patient with bronchial asthmahad been prescribed salbutamol, whichled to disappearance of bronchiospasmsymptoms. It happened due to stimulati-on of:

A. β2-adrenoreceptorsB. α1-adrenoreceptorsC. Muscarinic acetylcholine receptorsD. Acetylcholine synthesisE. β1-adrenoreceptors

146. Choose the most efficient way ofconvallariae glycoside administration foracute cardiac failure treatment:

A. IntravenousB. IntramuscularC. SubcutaneousD. InternalE. Inhalational

147. A doctor has prescribed a nonsteroi-dal anti-inflammatory drug to relieveinflammation and pain syndrome. Namethis drug:

A. Diclofenac sodiumB. GlibenclamideC. LoratadineD. PrednisoloneE. Calcium chloride

148. A 55-year-old patient had been di-agnosed with angina pectoris. Calcium

channel-blocking agent was prescribed fortreatment. Name this agent:

A. AmlodipineB. AtenololC. GuanethidineD. ReserpineE. Labetalol

149. A patient suffers from mucosaldryness and mesopic vision disorder. Whatvitamin deficiency causes these symptons?

A. �B. �C. �D. �E. D

150. Microorganisms that reach blood andother biological systems have negativesurface charge. What surfactants are usedas antibacterial agents to suppress the acti-on of microorganisms?

A. CationicB. AnionicC. LyophilicD. LyophobicE. Micellar

151. A ready-made drug was inoculatedon Sabouraud’s agar and incubated under22oC for 5 days. This nutrient medium wasused to determine the following:

A. Number of mold and yeast fungiB. Total number of bacteriaC. Presence of E. coliD. Presence of S. aureusE. Presence of Salmonella

152. The second stage of detoxificati-on involves joining certain chemicalcompounds with functional groups of toxi-nes. Select one such compound:

A. Glucuronic acidB. Higher fatty acidsC. CholesterolD. GlucoseE. Pyruvate

153. Fatty acids arrive into mitochondria,and there their oxidation occurs. Name thevitamin-like substance that takes part intransportation of fatty acids through mi-tochondrial membrane:

A. CarnitineB. CholineC. BiotinD. Pantothenic acidE. Folic acid


154. A 5-year-old child presents withabdominal distension, abdominal cramps,and diarrhea occurring 1-4 hours afterdrinking milk. Described symptoms arecaused by the lack of enzymes that breakup:

A. LactoseB. GlucoseC. MaltoseD. SaccharoseE. Fructose

155. Fajans titration with fluorescein isperformed within the following pH rangeof a medium:

A. 7-10B. 1-3C. 3-5D. 5-7E. 10-13

156. Electrode made according to thescheme Red, Ox, H+ | Pt belongs to thefollowing type:

A. Complex redox electrodeB. Ion-selective electrodeC. Electrode of the second kindD. Electrode of the first kindE. Gas electrode

157. A plant has erect stem with onlyone leaf growing from each node. Whatphyllotaxy is characteristic of this plant?

A. AlternateB. OppositeC. VerticillateD. DichotomousE. Parallel

158. Plant pathogens are represented byvarious microorganisms: bacteria, fungi,actinomycetales, viruses. Name the mainlocation of plant pathogens in the naturalenvironment:

A. SoilB. WaterC. AirD. Plant partsE. Plant vascular system

159. During ultrasound investigation apatient was diagnosed with bilateralrenal artery stenosis of atheroscleroticgenesis. Specify the bioactive substancethat due to its excessive secretion is thekey component of arterial hypertensionpathogenesis in the given case:

A. ReninB. CortisolC. VasopressinD. NoradrenalineE. Thyroxin

160. Micelle of a colloid surfactant willhave the following structure in a certainsolvent: polar groups are turned towardsthe solvent, while radicals are facing themicelle center. What solvent is it?

A. WaterB. TolueneC. BenzeneD. TetrachloromethaneE. Hydrogen sulfide

161. What cations of the V analytical groupcan be detected by hydrolysis?

A. Antimony and bismuthB. ManganeseC. Iron (II)D. MagnesiumE. Iron (III)

162. A solution of magnesium mixture wasadded into solution with anions of the 1stanalytical group. White crystalline precipi-tate was produced. What anions cause suchanalytical effect?

A. PO3−4 and AsO3−

4

B. AsO3−3

C. S2O2−3

D. SO2−3

E. C2O2−4

163. Albumine, blood serum protei-ns, and gastric juice pepsin consist ofmacromolecules of polypeptide chainsthat are joined with hydrogen bonds intohydrophilic spheres. These proteins arenamed:

A. GlobularB. FibrillarC. StructuralD. SyntheticE. Artificial

164. What drug group has the mostpronounced vasodilatory action, and haslittle effect on cardiac conduction systemand miocardial activity?

A. Dihydropyridine derivativesB. Phenylalkylamine derivativesC. Benzodiazepine derivativesD. Sulfonylurea preparationsE. β-adrenoceptor agonist

165. A woman is to be prescribed a


narcotic analgesic for labor pain relief.What drug is indicated in this case?

A. Promedol (Trimeperidine)B. MorphineC. Papaveretum (Omnopon)D. CodeineE. Fentanyl

166. A woman, who during the 5th-10thweeks of her pregnancy had been taki-ng sodium valproate for treatment ofher epilepsy, gave birth to a child withpathology of the vertebral column (splitspine). What side effect of the drug causedsuch malformation?

A. TeratogenicB. MutagenicC. EmbryotoxicD. FetotoxicE. Sensitizing

167. A patient with acute bronchitis wasprescribed an expectorant that causedbronchial spasm after the patient hadtaken it. What drug of those listed belowcan cause such side effect?

A. AcetylcysteineB. SalbutamolC. Validol (Menthyl isovalerate)D. PlatyphyllinE. Prenoxdiazine (Libexin)

168. A patient was visiting a pharmacy,when he suddenly felt unwell. Hedeveloped palpitations, rapid heart rate,pain in the chest that after several minutesspread to the left scapula and left side ofthe head. What condition should be consi-dered first?

A. Ischemic heart diseaseB. Peptic gastric ulcer diseaseC. DysphagiaD. PneumoniaE. Somatoform autonomic dysfunction

169. Prolonged application of broadspectrum antibacterial drugs resulted inthe patient being hospitalised with di-agnosis of candidiasis. What side effectof antibiotic therapy has developed in thepatient?

A. DisbacteriosisB. Endotoxic reactionC. Toxic reactionD. Allergic reactionE. Formation of resistant microorganismstrains

170. A 37-year-old patient with peptic

gastric ulcer disease was prescribed amedicine as a part of his multimodalitytherapy. The medicine lowers acidity ofgastric juice, inhibits �+, �+-adenosinetriphosphatase, decreases the volume ofgastric secretion and pepsinogen producti-on. It is a prodrug. Name this medicine:

A. OmeprazoleB. FamotidineC. Gastrozepin (Pirenzepine)D. RanitidineE. Phosphalugel (Aluminium phosphate)

171. A cultivated plant has green berrylikefruit and underground sprout modificati-ons - tubers. The described plant is:

A. Solanum tuberosumB. Соnvalaria majalisC. Polygonatum odoratumD. Atropa belladonnaE. Solanum lycopersicum

172. Elongated narrow prismatic crystalswith sharpened points were detectedduring microscopic investigation ofConvallaria majalis mesophile. Thesecrystals are:

A. StyloidsB. DrusesC. Crystalline sandD. CystolithsE. Perigonium

173. Students should identify the followingto determine the sex of a flower:

A. Stamens and pistilsB. Flower cup and corollaC. Pedicle and receptacleD. SymmetryE. Colour and type of indumentum

174. A doctor prescribed a herbal drugwith flavonoid complex of Silybum mari-anum to a patient suffering from chronichepatitis. This hepatic protector stimulatesprotein synthesis, normalizes phospholipidmetabolism, acts as an antioxidant. Namethis drug:

A. SilymarinB. EssentialeC. GalstenaD. ThiotriasolineE. Ursodeoxycholic acid

175. A pharmaceutical manufactureproduces a drug, that is an animal antibi-otic. Point out this drug among those listedbelow:


A. LysozymeB. GramicidinC. NovobiocinD. PhaseolinE. Chloramphenicol

176. A patient has been receivingTheophylline - inhibitor of cyclic adenosi-ne monophosphate phosphodiesterase -for a week. What hormone can increaseits action due to such treatment and causehyperglycemia?

A. GlucagonB. TestosteroneC. AldosteroneD. InsulinE. Estradiol

177. To detect anions in a solution by fracti-onal method a reaction with iron (III)chloride was performed in acid medium.The solution coloured red-violet. Whatanion is the cause of such analytical effect?

A. SalicylateB. ChlorideC. NitrateD. BromateE. Phosphate

178. An impression smears of the deadperson’s brain and salivary glands revealedNegri bodies, when coloured with Mannmethyl blue-eosin stain. These resultsconfirm the presence of the following di-sease:

A. HydrophobiaB. InfluenzaC. ParotitisD. ParainfluenzaE. Encephalitis

179. Preparations of colloid silver -Protargol (silver proteinate) and Collargol(colloid silver) - contain proteinecompounds besides their active substance.What is the function of proteins in thesepreparations?

A. Protection of colloid solution againstcoagulationB. Increased storage timeC. Decreased side effectsD. Improved preparation technologyE. Increased bactericidal action of silver

180. Adrenomimetic agents are differenti-ated into selective and non-selective.What drug is an agonist of β2-adrenergicreceptors and can be used for treatment ofbronchial asthma?

A. SalbutamolB. MetoprololC. AtenololD. Anaprilin (Propranolol)E. Nebivolol

181. A 25-year-old-patient with the IIdegree thermal burns addressed a doctor.Objectively: there are large blisters on theupper limbs; the blisters are filled withclear exudate containing mostly water andalbumines with isolated leukocytes. Namethe type of the exudate:

A. SerousB. Catarrhal (mucous)C. FibrinousD. PurulentE. Hemorrhagic

182. A seed of a legume contains proteinsand fatty oil. Name this legume:

A. Glycine hispidaB. Vaccinium myrtillusC. Sinapis albaD. Astragalus dasyanthusE. Datura stramonium

183. Rhizome of a species belonging tothe Asteraceae family is polycephalous,succulent, has lysigenous cavities,accumulates inulin. Such undergroundorgan is characterisic of:

A. Inula heleniumB. Hyoscyamus nigerC. Digitalis grandifloraD. Sorbus aucupariaE. Helianthus annuus

184. What drug is used in treatment regi-men for peptic ulcer disease to eliminateHelicobacter pylori?

A. ClarithromycinB. TienamC. BiseptolD. ChloridineE. Sulfalene

185. Sodium hydroxide was added to asolution. Precipitation occurred. The preci-pitate was initially white and becamebrown later. It indicates the presence ofthe following in the solution:

A. Manganese (II) cationsB. Lead (II) cationsC. Potassium cationsD. Calcium cationsE. Barium cations

186. What group of drugs is characterizedby development of drug addiction as a side


effect?

A. PsychosedativesB. Cholinergic antagonistsC. Adrenergic drugsD. DiureticsE. Emetics

187. Some drugs have the form of colloidsolutions. What size of dispersed phaseparticles corresponds with colloidal di-spersion?

A. 10−7 − 10−9 mB. 10−5 − 10−7 mC. 10−10 − 10−11 mD. 10−5 − 10−3 mE. >10−3 m

188. A local general practitionerrecommends taking interferon forinfluenza prevention. What is the mechani-sm of action of this drug?

A. Blocks virus protein synthesisB. Blocks virus strippingC. Inhibits virion exit from cellsD. Prevents adsorption of virus in cellreceptorsE. Disrupts the process of virus assembly

189. What cation can be detected withChugaiev’s agent (Dimethylglyoxime)?

A. Ni2+

B. Ca2+

C. �+

D. Mn2+

E. Co2+

190. Dry many-seeded monocarp fruitopens along its ventral suture. It can beidentified as:

A. FollicleB. LegumeC. NutletD. DrupeE. Capsule

191. Determination of silver salts byammonium thiocyanate titration isperformed in the presence of the followingindicator:

A. (NH4)Fe(SO4)2B. FeSO4C. FeCl2D. (NH4)2SO4E. NH4SCN

192. After ishemic stroke a 67-year-oldpatient developed reduced mobility of theleft leg. Name this condition:

A. ParesisB. ParalysisC. MyastheniaD. HyperkinesiaE. Tremor

193. A 32-year-old patient with cerebellartumor was delivered to an admission roomof a hospital. The patient presents withataxia that can be characterized by:

A. Disrupted coordination of movementsB. Involuntary contraction of skeletalmusclesC. Increased muscle toneD. Pathological reflexesE. Irregular force and direction ofmovements

194. A doctor prescribed diazepam toa patient with anxiety disorders. Whatpharmacological effect is the reason forsuch a prescription?

A. AnxiolyticB. AnticonvulsantC. Anti-inflammatoryD. AntianginalE. Hypotensive

195. A 40-year-old man presents with rapidweight gain after he had suffered a severecraniocerebral trauma. At doctor’s exami-nation the patient’s weight was 125 kg, withhis weight being 175 cm. What mechanismof obesity development is the most likelyin this case?

A. HypothalamicB. AlimentaryC. HormonalD. HereditaryE. -

196. Specify the parameters thatcharacterize the sensitivity of analyticalreaction:

A. All the parametersB. Minimal volume of borderline dilutedsolutionC. Borderline dilutionD. Absolute sensitivityE. Borderline concentration

197. Specify the name of the carbohydrategiven in

according to the systematic nomenclature:


A. 5,6,6-trimethyl-1-heptenB. 2,2,3-trimethyl-6-heptenC. 5-tert-Butyl-1-hexeneD. 2-tert-Butyl-5-hexeneE. 2,2,3-trimethyl-6-hexene

198. M. I. Konovalov’s reaction is asfollows:

A. ��4 + HNO3(diluted) = CH3NO2 +H2OB. ��4 + H2SO4 = CH3SO2OH + H2OC. 2�2�5Cl + 2Na = C4H10 + 2NaClD. �6�6 + HNO3(concentrated) =C6H5NO2 + H2OE. ��4 + Cl2 = CH3Cl + HCl

199. Hydrogen atom attaches to thefollowing carbon-1-pentene atom duringelectrophilic addition of hydrogen bromi-de:

A. С1B. С2C. С3D. С4E. С5

200. To chemically distinguish betweenglycerine and ethylene glycol

it is nececcary to apply:

A. KHSO4B. CuOHC. Cu(OH)2D. NaOHE. NaCl

INSTRUCTIONAL BOOK

Testing Board

TEST ITEMS FOR LICENSING EXAMINATION: KROK 1. PHARMACY.

Kyiv. Testing Board.

(English language).

Approved to print 26.08./№71. Формат 60х84 1/8

Offset paper. Typeface. Times New Roman Cyr. Offset print.

Conditional print pages 24. Accounting publishing pages 20.

Issue. 126 copies.

List of abbreviations

A/G Albumin/globulin ratio A-ANON Alcoholics anonymous ACT Abdominal computed tomography ALT Alanin aminotranspherase AP Arterial (blood) pressure AST Aspartat aminotranspherase BP Blood (arterial) pressure BR Breathing rate bpm Beats per minute C.I. Color Index CBC Complete blood count CHF Chronic heart failure CT Computer tomography DIC Disseminated intravascular coagulation DCC Doctoral controlling committee DM-2 Non-Insulin dependent diabetes mellitus DTP Anti diphtheria-tetanus vaccine ECG Electrocardiogram ESR Erythrocyte sedimentation rate FC Function class FEGDS Fibro-esphago-gastro-duodenoscopy Gy Gray GIT Gastrointestinal tract Hb Hemoglobin HbA1c Glycosylated hemoglobin Hct, Ht Hematocrit HDL

HR

High-density lipoproteins

Heart rate IDDM Insulin dependent diabetes mellitus IHD Ischemic heart disease IU International unit MSEC Medical and sanitary expert committee NIDDM Non-Insulin dependent diabetes mellitus pCO2 CO2 partial pressure pO2 O2 partial pressure Pm Per minute Ps Pulse rate R Roentgen RBC Red blood count Rh Rhesus RR Respiratory rate S1 (S1) Heart sound 1 S2 (S2) Heart sound 2 TU Tuberculin unit U Unit USI Ultrasound investigation V/f Vision field WBC White blood count X-ray Roentgenogram

Documents

Test items for licensing examination Krok 1 PHARMACY · D. Exoderm E. Mesoderm 19. The Mohr method is used to determi-ne sodium chloride mass concentration in isotonic solution. Titration