View
224
Download
2
Embed Size (px)
Citation preview
The Acute Phase Response
• Activated in response to “alarm” cytokines:IL-1, IL-6.
• Enhances host resistance, minimizes tissue injury, promotes resolution and repair of inflammatory lesion.
The Inflammatory Response
• Produced through:(I) Ab Independence(a) Tissue Injury(b) Alternate complement pathway(II) Ab Dependence(a) Classical complement(b) Mast cell degranulation
Mediators of Inflammation
Mast Cell Mediators
Chemokines`
• Function: Stimulates chemokinesis and chemotaxis (a chemotactic cytokine.)
• Two types: – C-C (produced mainly by activated T cells -
acts mainly on subsets of m/p’s and TH cells). e.g. RANTES
– C-X-C (produced mainly by m/p’s, endothelial cells, fibroblasts - acts mainly on neutrophils). e.g. IL-8
The Complement Pathway
Biological Functions of Complement
Biological Functions of Macrophages
• Phagocytosis• Antigen-presenting
cell• Cytokine production
Innate vs Acquired Immunity
Innate-Adaptive Immunity
The Antiviral Response
Fc Receptors
Antiviral Immunity
TNF
Delayed-Type Hypersensitivity I
T Cell Receptor
Mechanism of T Cell Triggering
Successful Effector Cell Stimulation Requires Accessory Molecules
TH1 vs TH2
TH1 vs TH2