The Aging Brain

• The brain changes with age• The frontal cortex & hippocampus are critical to learning,

memory, planning and other cognitive activities, shrink in size

• Changes in neuron communication • Neuron damage & death• Reduced blood flow to the brain• Change = reduced brain function

Age-Associated Memory Impairment (AAMI)

• A condition characterized by mild cognitive & memory decline that occurs as part of the normal aging process

• It is believed to be the result of chemical changes in the brain, as well as reduced brain volume

• It affects close to 1 in 3 people aged 60 to 78

• AAMI is a condition related to normal aging, while Alzheimer’s disease (AD) is associated with serious neuro-degeneration

Age-Associated Memory Impairment (AAMI)

What are the signs of AAMI?

• Difficulties in memory such as misplacing

objects or forgetting names/words

• Trouble communicating

• Delayed reaction time

• Impaired ability to multi-task

• 50 years of age or older

• Absence of dementia

What Causes Cognitive Decline-Part1?

Excess Accumulation of Toxic Amyloid-beta (Ab) Protein:

• “Strangles” neurons within the brain • Neurons malfunction and die• Impairs “communication” in the brain which causes

memory and cognitive decline

What Causes Cognitive Decline-Part 2?

Hippocampus Shrinkage

• The Hippocampus is a structure in the brain that is involved in memory, learning and spatial navigation

• Neuron death causes a decrease in the size of the hippocampus and overall brain size

• Loss of hippocampus size is associated with lower scores on memory tests

Hippocampus

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Age (years)

• By the age of 25, cognitive performance has reached it’s peak and declines rapidly after the age of 40

Decline In Hippocampus Volume Accelerates Around Age 40

• Poor diet (excess sugar, nutrient deficiency, processed food)

• Lack of physical activity• Excess body weight• Chronic Inflammation• Social Isolation• High stress• Declining hormone levels

Factors Associated with Cognitive Decline

• Bacopa-Powerful protective effects on the brain and nervous system

• Citicoline-Enhances neurotransmitter balance in the brain

• Curcumin-Identified as one of the compounds responsible for low rates of Alzheimer’s disease in India

• GABA-Prevents overstimulation of the brain

• Ginkgo Biloba-Increases blood flow to the brain

• Homotaurine- Prevents shrinkage of the Hippocampus and neuron death

• Lion’s Mane-Calms the nervous system to improve memory and concentration

• Phosphatidylserine-Plays an essential role in brain cell membrane structure

• R-Lipoic Acid-Protects neurons from damage

Brain Nutrients

• Homotaurine is an amino acid discovered in marine red algae

• VIVImind™ is supported by over $200 million and 15 years of scientific research, including 16 clinical studies with over 2000 individuals in Canada, USA and Europe

• The first nutraceutical to undergo Phase III clinical research in large, state-of-the-art, clinical trials in the field of cognition

• It is Clinically proven to prevent Hippocampus volume loss by 68%!

Why VIVImind™?

How Does VIVImind™ Work?

Homotaurine crosses the blood-brain barrier and Inhibits the Formation of Amyloid Tangles to

Protect Against Neuron Death

VIVImind™ Clinical Trial Results

• 1052 patients diagnosed with mild to moderate Alzheimer’s disease received a placebo or Homotaurine for 18 months

• 33% improvement in cognitive performance with Homotaurine• 68% reduction in Hippocampus shrinkage with Homotaurine

VIVImind™ Clinical Trial Results

• Results were even more effective in patients with the Apoe4 gene

Homotaurine and Alzheimer's Disease

AD is a model of accelerated cerebral and cognitive aging• Common cognitive domains affected• Common neurological contributing factors• Exacerbating effect of Aβ

VIVImind™

• Reduces Aβ-induced toxicity• Protects memory throughout the aging process as

demonstrated in patients diagnosed with AD

How to Use VIVImind™

Dosage adults (50 years and older) :2 capsules(50 mg), twice daily with food• Start with 1 capsule at bedtime for one week and progress to 1

capsule twice daily for an additional week before starting normal dosage

• Do not crush, blend or mix the capsules. Swallow whole.

Duration :• Efficacy is dependant on Long-term use. Use for a minimum of 6

months for beneficial effects.

VIVImind™ Safety

• Safe and well tolerated upon chronic use

• Does not bind to plasma proteins

• Does not interfere with liver enzyme (CYP450) activity

• Does not interfere with Warfarin

VIVImind™

Supports the Memory Centre of the Brain

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