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The American Society of PharmacognosyThe ASP Newsletter Volume 45 Issue 2
50
www.phcog.org
In This Issue The Making of ASP’s New Website
by Dr. John Cardellina
continued on page 3
ASP 50th Anniversary Meeting The scientific program for ASP’s Golden Anniversarycelebration,June27-July1,2009,isnowset.ThemeetingprogramwillactuallybeginSaturdayevening,June27,withareflectiononthehistoryoftheASP,tobefollowedbythewelcomingreception. ThescientificprogrambeginsinearnestonSundaymorning,June 28, and will consist of the Matt Suffness Award, NormanR. Farnsworth Research Achievement Award, and Tyler Prizepresentationsandlectures,10invitedspeakers,72contributedshorttalksand543postersinthreesessions.TheSuffnessAwardwinnerisDr.ShengminSangofNorthCarolinaCentralUniversity,whileDr.Kuo-HsiungLeeoftheUniversityofNorthCarolinaisreceivingtheNormanR.FarnsworthResearchAchievementAward.Dr.AdolfNahrstedtoftheUniversityofMuensterwillreceivetheTylerPrizeforresearchonbotanicals. InvitedspeakersincludeDrs.BradleyMoore,ScrippsInstitutionof Oceanography and University of California at San Diego, SanDiego,California,Franz-JosefMarner,UniversityofCologne,Cologne,Germany,CindyK.Angerhofer,AvedaCorporation,Blaine,Minnesota,
The ASP website has undergone a dynamic change. Phcog.org now has a colorful new look with beautiful photos and an exciting new layout! ASP’s website designer and ASP Past President Dr. Bill Baker’s graduate student, Mr. Jeremy Beau, tells the Newsletter how he conceptualized and built ASP’s new online image.
TheASPbegan thewebpage redesignproject to update the lookandfeel,advancethefunctionality,andre-investigatetheuserflowofthesite.Thesiteneededtobemademoredynamicandmoremanageable.WhilemanyattheASPfeltthattheoriginalsitewaseasytonavigate,theconsensuswithnewcomerswasthatitwasnotsointuitive,andthatitdidnotencouragerepeatviewing. As a natural products chemist and web designer, I became veryinterestedinworkingonthisproject.Beforethis,Ihadworkedwithseveralorganizations to help them better understand their web presence andimplement improvements. Thus, I created a proposal for the new face oftheASPwebsite.Dr.BillBaker,myadvisor, introducedmeandpassedtheproposaltotheASPExecutiveCommittee.ThememberswereenthusiasticaboutmyideasandIwasselectedtobeginthework. Thefirstitemofbusinesswastheaestheticsofthewebpage.Sofar,theonlygraphicalrepresentationoftheASPwasitslogo.TheASP Newsletter hadaniceupdatedversionofthelogosoitwasimportanttomakethesame
byMr.JeremyBeau
continued on page 7
Summer 2009
FeaturesASP50thAnniversaryMeeting 1ASP’sNewWebsite 1
AnnouncementsHamiltonCollegeCelebratesDr.Kinnel 7ExcerptsfromtheASPAnthology 82008SchwartingandBealAwards 12InMemoriam:Dr.JackK.Wier 12ASPArchivestoLloydLibrary 13JNPHonorsDr.Kingston 14
DepartmentsEditorsCorner 2Contributor’sCorner 2ConferenceCalendar 15BehindtheScenesinPharmacognosy 16FromtheArchives 17MembershipInformation 18
WaikikiBeach,thelocationofthe50thAnniversaryASPMeeting.
The ASP Newsletter Vol. 45(2) 2
Editor’s Corner
EdwardJ.Kennelly,Ph.D.Editor-In-Chief
AmyC.KellerAssistantEditor
JamesT.LylesLayoutEditor
Thecontributiondeadlinesare:SpringIssue Feb. 15SummerIssue May 18FallIssue Aug. 18WinterIssue Nov. 17
Pleasesendinformationto:
EdwardJ.Kennelly,Ph.D.EditorInChief,ASP Newsletter
DepartmentofBiologicalSciences
LehmanCollege,CUNY250BedfordParkBlvd.West
Bronx,NY10468718-960-1105
Newsletter Staff
The Society offers aplacementservicetoaidourmembersinseekingpositionsoremployees.ThisserviceisavailableonlytoASPmembersand is free to both theapplicant and the employer.Formoreinformationseetheserviceswebsite.
www.phcog.org/employment.html
Employment Service
In this issue of the Newsletter, we anxiouslyanticipate the activities surrounding the 50th Anniversary of the Society. Drs. Roy Okudaand John Cardellina write about the extensivescientific and social activities that have beenplannedforthisspecialAnnualMeetinginHawaii.Thereisstilltimetoregister! It is amazing to consider the growth of theSociety in the past 50 years. We chart ourbeginnings as a small outshoot of the PlantScience Laboratory Seminar. Our numbers have
increased,andthescopeandbreadthofresearchers inourSocietyhaveexpandedinwaysthatfewpeoplecouldhavepredicted50yearsago. Dr. Gordon Cragg’s history book of the ASP has now beenshippedtoallactivemembers.ItisagreatachievementforourSocietyto have such a detailed and comprehensive book that documentsouractivitiesandachievements. In thisNewsletter,wepresentthecontinuationof theMarch issue’sexcerpt fromDr.Cragg’sbook. Incollaboration with ASP NewsletterLayoutEditorMr.JamesLyles,Dr.CragghasalsocreatedawonderfultimelineoftheSociety. AspartoftheSociety’s50thAnniversary,theASPwebsitehasundergoneamajorrevision.ThisworkwasspearheadedbyMr.JeremyBeau,ayoungermemberoftheSociety.ThewebsiteisoneofthefirstinteractionsmanypeoplehavewiththeSociety,andupgradingthisresourceisgreatforbothmembersandnonmembersalike.Thanks,Jeremy, for your timeandeffort inmaking thisa reality in suchashortamountoftime,andwithsuchcreativeenergy! The Journal of Natural Products special issue honoring Dr.David Kingston is also described in this Newsletter. Dr. Kingston’scommitmenttotheJournalandtheSocietyarewellknowntomanymembers,includinghisserviceaspastPresidentofASPandAssociateEditoroftheJournal of Natural Products.Wearepleasedtoprofileone of the papers in this issue by Dr. John Beutler in our regularcolumn,“BehindtheScenes inPharmacognosy”.Journal of Natural ProductsEditor,Dr.DouglasKinghorn,alsoannouncesthewinnersoftwoimportantJournalawardsinaseparatearticle. In this issue, Dr. Georgia Perdue takes a rest from herregularcolumn,“BehindtheScenesinPharmacognosy”,andinsteadformulatesaninteresting“FromtheArchives”columnthatdescribeshowanumberofimportantmembersofASPwerecoincidentallyfromthesamelittletowninMassachusetts. I look forward to seeing many members of the Society atthe Annual Meeting. If you have comments or suggestions for theNewsletter,[email protected],orspeakwithmepersonallyattheMeeting.Haveawonderfulandproductivesummer.
The ASP Newsletter Vol. 45(2) 3
TomasHudlicky,BrockUniversity,St.Catharines,Ontario,Canada,HyeSookYun-Choi,SeoulNationalUniversity,Seoul,Korea,JustinDuBois,StanfordUniversity,PaloAlto,California,DaisukeUemura,KeioUniversity,Tokyo,Japan,Pei-YuanQian,HongKongUniversityofScienceandTechnology,Kowloon,HongKong,ValerieJ.Paul,SmithsonianMarineStation,FortPierce,Florida,andRosarioRojas,UniversidadPeruanaCayetanoHeredia,Lima,Peru. WiththeexceptionofsomeofthejointmeetingswiththeEuropeansocieties,thiswillbethelargestprogramin the history of the ASP. Over 665 abstracts were submitted;more than 165 of thosewere requests for short oralpresentations,promptingustoexpandthenumberofsessionstoaccommodateadditionalshorttalksfromaplanned63toatotalof72contributedoralpresentations.ThetopicsorthemesofthesecontributedtalksessionsrepresentthediversityofresearchconductedbyASPmembersandincludeASPstudentresearchawards,microorganisms,pharmacologyofnaturalproducts,bioactiveconstituentsofplants,cyanobacteria,commercialbotanicals,pharmacologicalscreensandnaturalproducts,biosynthesis, chemistryandecologyofmicrobesand insects,uniqueapproaches tonaturalproductproblems,marinenaturalproducts, synthesisofnaturalproductsandanalogs,determining theabsoluteconfigurationofnaturalproducts,sessionsinhonorofDrs.JohnDalyandRichardMoore,andaprovocativesessiononthecontinuingevolutionofpharmacognosy. Thismeetingwillhaveadecidedlyinternationalflavor,withspeakersfromCanada,Mexico,Brazil,Tahiti,Japan,Korea,China,NewZealand,Australia,SouthAfrica,Austria,Germany,Sweden,UnitedKingdom,andIsrael,joiningourAmericanmemberstocelebrate50yearsofresearchinandservicetopharmacognosy.
ASP 50th Anniversary Meetingcontinued from page 1
ASP 50th Anniversary Meeting: Hawaii Information
Aloha!FromJune27-July2,2009,theASPwillcelebratethe50thAnniversaryofourfoundingwithauniqueandhistoricmeetinginWaikikiBeach,Hawaii.Byallmeasures,thiswillbeoneofthemostexcitingmeetingsinthehistoryofourSociety.Asofthismoment,nearly600areregisteredtoattend,representing33countriesfromeverycontinentexceptAntarctica.ThePresidentsorrepresentativesarebeingsentfromsixsistersocieties–PhytochemicalSocietyofEurope,FrenchAssociationfortheEducationandResearchofPharmacognosy,SocietyforMedicinalPlantandNaturalProductResearch,ItalianSocietyofPharmacology,theKoreanSocietyofPharmacognosy,andtheJapaneseSocietyofPharmacognosy.An impressive scientificprogram,chairedbyDr. JohnCardellina, includes10plenary speakers, threeawardpresentations,72contributedoraltalks,and542posters!Itcanbesaidthatourmeetingwillbeatrulyglobal perspectiveofpharmacognosy! Locatedinthemiddleofworld-famousWaikikiBeach,theSheratonWaikiki(SW)Hotelwillbetheofficialmeetingvenueforourmeeting.Weareveryluckytobeholdingourmeetingatthisperiod,asmostofthehotelhascompletedamultimilliondollarrenovation.Allguestroomshavebeenupdated,andtheconventionballroomsjustreopenedinthepastfewmonthsaftermajorremodeling.PerhapsthemostspectacularnewfeatureoftheSWisthebrandnewHelumoaWaterPlayground,aseriesofpools,waterslidesandjacuzzissetrightattheedgeofthePacificOcean.TwoofourmeetingeventswillbeheldhereanditpromisestobethemostuniqueexperienceeverforanASPmeeting!Somerenovations
arestillongoing,butthecompletedportionswillmorethanmakeupforsomesmall inconveniences.NearlyallofourmeetingareashaveanunobstructedviewofDiamondHeadandWaikikiBeach! OnSaturday,June27from5pmto7pm,Dr.BarryO’Keefehasorganizedaspecialprogramonthe“50YearsofHistoryoftheASP,”featuringamultimediaprogramandspeakersrepresenting each of the five decades of the ASP. ThisprogramwillgiveaninformativeandentertainingreviewoftheSocietyfrombirthtothecurrentstatus,andeverythingin between. Immediately after the history program, the socialprogramwillbeginwithanoutdooropeningreceptiononSaturday evening around the Helumoa Playground. Youcouldbesittingrightnexttotheoceanwithyourfavoritedrink in hand, watching for the “green flash” at sunset!
OurspecialeventforMondaynightwillbeaHawaiianluau
byDr.RoyOkuda
TheHelumoaPlaygroundattheSheratonWaikikiHotel.
continued on page 4
The ASP Newsletter Vol. 45(2) 4
buffet,withfoodrepresentingHawaiianandotherPacificRimfoods.EntertainmentwillbeprovidedbythespectacularLegendsofPolynesiatroop,andisnottobemissed!ThemeetingwillclosewiththeASPAnnualBanquetonWednesdayevening,whichwillrecognizethecontributionsofkeymembersoftheSociety. AtleasttwoworkshopswillbeheldonSaturday,June27.AnewworkshopondereplicationmethodswillberunbyDrs.MurrayMunroandJohnBluntoftheUniversityofCanterbury,NewZealand.Thereisnochargeforthisworkshopbutenrollmentislimitedto25people.ASingleLaboratoryValidationworkshopwillalsobegiven,andisforanyonewhoperforms,supervises,manages,audits,oroverseesthevalidationofanalyticalmethodsforthequalitycontrolofdietarysupplements.There is a feeof $250 for thiscourse. Information and registration on bothworkshops may be found on the meetingwebsite. AsistraditionalfortheASPmeeting,Tuesday afternoons are left open for you todecidehowyouwishtospendyourtime.Youmaywishtolieonthebeach,goshopping,orgo sightseeing.Or, if you are interested,wehavearrangedforthreeexcursions.First,theASP Golf tournament: Dr. Robin Kinnel hasarrangedforateetimeintheafternoonattheEwa Beach Golf Club. The package includesround trip transportation, green fees andclubrentals. For [email protected]. Secondly, the Lyon Arboretum tour ($15) will lead you through a tour of the University of Hawaii’s researcharboretum,whichmaintainsauniquecollectionofHawaiianandotherPacificregionplants.LocatedinlushManoaValley,aftertouringthearboretumyoumaywanttotakeashorthiketoManoaFalls,orrelaxintheTreetopsrestaurant. Lastly,theDiamondHeadHike($10)willstartfromtheinsideofDiamondHeadcrater,andwalktotherimforaspectacularviewofWaikikiandthesurroundingcity.RegistrationandpaymentfortheLyonandDiamondHeadtourswillbecollectedattheregistrationdeskonly.Bothhavelimitedcapacity. In addition, the SheratonWaikiki TourDeskmaintains a schedule of awide variety of tours of various typesand durations. Information can be found on their site: www.sheraton-waikiki.com/act.htm. Advance registration isrecommendedforalltours,andthesetoursareavailableonmostdaysoftheweek. Oneplacetolookforideasonactivitiesis:www.101thingstodo.com/hawaii/oahu/index.php
Other Useful InformationGettingfromtheHonoluluAirporttotheSheratonWaikikiorotherhotels.Most hotels inWaikiki do not offer their own shuttle service, but there are other goodoptions.Thesearedescribedindetailonthe“Travel”linkonthemeetingwebpage:www.phcog.org/AnnualMtg/Air_Travel_and_Local_Trans.html
ClimateGenerally,daytimetemperatureswillbeinthe80s(F)andeveningsinthe70s(F).Ifthetradewindsareblowing,humidityismoderate.
CurrencyExchangeThe SW is able toexchangemostmajorworld currencies.Currencyexchangekiosks areavailable at theHonolulu Airport and at various locations inWaikiki. ATMs are commonthroughoutthearea.
ChildcareChildcareservicesareavailableattheSWthroughPoppinsDayCare:www.sheraton-waikiki.com/act_keiki_aloha.htm
DiamondHead
continued from page 3
continued on page 5
Forafunthingtodo,investigatethislivewebcamofWaikiki,notfar from SW. Once in Waikiki,people can give their friendsthe URL, or Google “Waikikibeachwebcam,” then stand infrontof theDukeKahanamokustatue on Waikiki Beach andwaveatthem,whereverintheworld they are. www.honolulu.gov/multimed/
waikiki.asp
ASP 50th Anniversary Meeting: Hawaii Information
InternetThemeetingwillhavean InternetCaféavailableuntil6pmformostdaysofthemeeting.Wireless internetservice isavailableinguestroomsforapproximately$13/day.InternetkiosksarescatteredthroughoutWaikiki.
ParkingParkingisavailableattheSWat$20/day(selfpark)or$27(Valet).ParkingisnotincludedforguestsstayingattheSW.Itisrecommendedthatyourentacarforonlythedaysyouneedone.RentalagenciesarescatteredthroughoutWaikiki.
WheelchairsIfyouneedawheelchairduringyourstay,contactGuestServicesforratesandreservations:(808)922-4422
ThingstoPackHat,sunglasses,andsunscreenlotion.
FOOD Hawaiiisalsoknownasthe“MeltingPotofthePacific”andthisismostevidentinthewiderangeoffoodofferingsthatyouwillfindintheislands.Everytypeofcuisineyouhaveheardof,andsomeyouneverheardof,canbefoundintheIslands.Letyoureyesandnosebeyourguide,butyouverylikelywillfindanewfavoritedishduringyourstay! Hawaiihassomeuniquedishesanduniqueadaptationsofotherdishes.Sometowatchforinclude:
•kaluapork-traditionallyawholepigcookedinanimu,orundergroundovencreatedbyheatedlavarock.•lomi lomi salmon - the Hawaiian version of seviche,madewith vinegar and lemon “cooked” salmon and
spices.•poi-mashedtaroroot,maybefermented.Arguablyanacquiredtaste!•haupia-coconutpudding.Yum!•shavedice-“snowcones”butwithauniqueHawaiiantwist.Tryitwithsweetened
adzukibeans,andwithmultipleflavors.•spammusubi - slice of spam on a block of rice, sometime wrapped with nori
(seaweed).•locomoco-scoopofrice,hamburgerpatty,andeggovereasy,smotheredwith
browngravy.•platelunch-usually,twoscoopsrice,macaronisalad,andameatorvegetarian
entrée,goodportablefoodtoeatonthebeach! Forthoseonabudget,thegoodnewsisthatitISpossibletogetdecentfoodinWaikikiforabout$10orlesspermeal,notcountingalcohol.Severalfoodcourtsexistwithinafive-minutewalkoftheSW,andhereyoucanfindfamiliaroutletsaswellasonesthatareuniquetoHawaii.RecentrenovationsandnewconstructionhaveresultedindozensofnewrestaurantsofallpricerangestoopennexttotheSW,soyourproblemisnotfindingwheretoeat,butwhichoneyouwanttotrytoday!Ifyouhavetimetowalkalittlefurtherortakeabus,theoptionsmultiplymanifold.Wewillprovidemapsandinformationforrestaurants,butifyouwanttopreviewtheoptionsnow,youcangotoGoogleMaps,andenter2255KalakauaAvenue, Honolulu,Hawaii,96815,then“searchnearby”forrestaurants. If you REALLY want to try authentic Hawaiian food, the closest toWaikiki is OnoHawaiianFood(726KapahuluAve.,abouta30minutewalkfromtheSW),butgetthereearlyaslinesareusuallyoutthedoor!Itisahole-in-the-wallbutconsistentlygetshighratingsfromlocalfolk.Ontheotherendofthespectrum,HawaiianRegionalCuisineisspearheadedbySamChoy(580N.Nimitz),RoyYamaguchi(226LewersinWaikiki)andAlanWong(1857S.King).Reservationsarerecommendedforthesethree! ThelocalCommitteewillhaveinformationandmapsavailabletohelpyoufindaplacetogetfood.ItisnotlikelyyouwillloseanyweightafterbeinginHawaii,sostartthatdietafteryoureturnhome!
continued from page 4
ASP 50th Anniversary Meeting: Hawaii Information
The ASP Newsletter Vol. 45(2) 5
The 50th Anniversary Meeting of the
American Society of Pharmacognosy
June 27 - July 1, 2009 Honolulu, HI
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Fifty Years of Natural Products andFifty Years of Natural Products and
Beyond: Celebrating the GoldenBeyond: Celebrating the Golden
Anniversary of the ASPAnniversary of the ASP
Confirmed Speakers:Hye Sook Yun-Choi (Seoul National Univ.)
Justin DuBois (Stanford)
Franz-Josef Marner (Univ. Cologne)
Bradley Moore (UCSD / Scripps)
Tomas Hudlicky (Brock Univ.)
Valerie Paul (Smithsonian)
P.Y. Qian (Hong Kong Univ. Sci & Tech)
Rosario Rojas (U. Peruana Cayetano Hereedia)
Daisuke Uemura (Keio Univ.)
Shengmin Sang (N. Carolina Central Univ.) - ASP Suffness Young Investigator
K.H Lee. (Univ. N. Carolina) - ASP Farnsworth Awardee
Adolf Nahrstedt (Univ. of Muenster) - ASP Tyler Award
Check the ASP website for updates www.phcog.org
Photo Credits: (1) Hawaii Tourism Authority/Joe Solem, (2-3) Hawaii Tourism Authority/Tor Johnson, (4) Hawaii Tourism Japan
The ASP Newsletter Vol. 45(2) 7
updateonthewebsite.Inaddition,wefeltthataddingabannerwithpicturesofnaturalproductsourceswasimportantinmakingthesitemoreattractive.Forthepictures,Ichosemacroorganismsthatwouldeasilyberecognizableasproducersofnaturalproductcompounds.Tokeepthingsfresh,Iaddedanimageslideshowonthefrontpageaswellasanimage
gallery. Whenshownthenewwebsite,ASPmemberswaxedenthusiastic.ASPPresidentGuyCarterrelated,“Ithinkthenewsitelooksgreat.Nicework.”Dr.Bakermentioned,“I’mquiteimpressedwiththenewlookofthewebsite,especiallyas itrepresentsafreshandappealingfaceoftheSocietyfor its50thAnniversary. I think ithasthepotentialtocapturetheinterestandimaginationofthosewithaninterestinnaturalproductsinawaytheformersiteneveraspired.Thatitcomesfromtheimaginationofgraduatestudentfromourownranksmakesitallthemorespecial.” Part of the redesignwas the implementationof new features.The Information Resources section of the sitewas improved toincludeaninteractiveASPEventsCalendar,updatednewssectionsand a more user-friendly Employment Services page. However,thisprojectwasnotjustaboutaddingnewflashyfeatures.Whenredesigninganywebsite,itisimportanttolookcloselyateachpageofthecurrentsiteandaskyourself“whydoesthispageexist?”Thatallowsyoutoidentifytheusefulnessoftheinformationandsubsequently target the page to better accomplish its necessary
goals.When redeveloping theASP site, I looked closely at the homepage anddecided its focus should be about thenewsandannouncementstokeepthecommunityinformed.TheconcisetopnavigationlinkscoupledwiththelefthandnavigationmenusallowedmetofocusbothoninformationalresourcesaswellastheASPmembercommunity. ASPmembersseemhappywiththenewwebsite.Dr.GuidoPaulicommented,“Verynicejob,Jeremy!Alltheelementsare there,doublenavigationwith top, leftmenusandelementsyouproposed.Actually,almost looks likeaJoomlasitetome;-).”Dr.RoyOkudanoted,“Visuallyandfunctionally,thenewsite isahuge improvementoverthevenerableASPsite.Itserveduswellforalongtime,butitistimetomoveon.Itisnolongerdrab,andhasalotofeyeappealtodrawpeoplein.IlikethescrollingphotosandthelistofcurrentJNPabstracts,andtheorganizationofthelinksintosectionsmakesiteasiertofindinformation.Therewillbetweaking,ofcourse,butthemainframeworkishere.”Thesitewasbuilt inmodernwebstandardsusingXHTML,CSS,andJavaScriptthat issupportedinallbrowsersonallplatforms.Thisaspectwasveryimportanttobothreachallusersandtobeeasytoupdate.Duringthedesign,Ifrequentlypostedupdatesandaskedforfeedbackfrommembers.Thisstepwascriticalinoptimizingthewebsite.Thereceptionwasexcellentinallofthephasesofdevelopmentandthecommentsandsuggestionswereveryhelpfulinmakingasiteintunewithnaturalproductsscientists.ItwasapleasuretoworkwitheveryoneandintheendIthinkwebuiltagreatwebsitetogether!ASPmemberDr.TadeuszMolinskinoted,“Amajorimprovement!Ilikeit.” WiththesuccessoftheASPwebsite,afriendandIfoundedaconsultingcompanynamedInvertedIncorporated.Weareworkingonseveralprojectssuchaswebdesign,cloudcomputing,greenbuilding,homeautomation,andhopefully,oneday,naturalproductsresearch.Formoreinformation,pleasevisitwww.inverted.com.
continued from page 1
The Making of ASP’s New Website
Mr.JeremyBeauhardatwork.
Hamilton College Hosts Celebration for ASP’s Dr. Robin Kinnel
AcelebrationofthecareerofASPmemberDr.RobinKinnelwasheldatHamiltonCollege,Clinton,NewYork,May1-2,2009.Dr.JerryMeinwaldofCornellUniversity,oneofthefoundersofthefieldofChemicalEcology,gavethekeynoteaddress. SeminarsovertheweekendincludedASPmemberDr.BillBaker,Dr.JasonKingsbury,andHamiltonalumni,withmusicalentertainmentprovidedbyDr.Meinwald. Thereisawebsiteforthecelebrationthatincludesadigitalguestbookwherevisitorscanleaveanoteorpostpictures.IfyouwouldliketoexpressyoursentimentstoDr.Kinnel,thiswouldbeagreatwaytodoso.Thewebsitecanbefoundathttp://rkinnel.chem.hamilton.edu/.
Dr. Ian Rosenstein contributed to this article
byMs.AmyKeller
Ms.
Pa
mel
a B
eau
The ASP Newsletter Vol. 45(2) 8
This month, the official ASP History Book, complied in honor of ASP’s 50th Anniversary, was mailed to current ASP members. In this issue of the Newsletter, we continue an excerpt of the book featured in our March issue. If you have not received the book, please contact ASP Treasurer Dr. David Slatkin at [email protected].
ASP HISTORY: 1976-1980Gordon Cragga and Harry Fongb
aNatural Products Branch, NCI-Frederick, Maryland 21702-1201 and bCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612
1. Introduction Theperiod1976-1980sawanumberofsignificantdevelopmentsintheSociety.Thenumberofactiveandassociatemembersgrewfrom314 in1976to487 in1980,while theannualdues rose from$20to$25. In1977,JackBeal tookoverastheEditorofLloydiafromArtSchwartingwhohadservedwithdistinctionfor16years.OnJanuary1,1979,thejournalnamewaschangedfrom Lloydia to the Journal of Natural Products (JNP),withtheapprovaloftheSocietyandtheTrusteesoftheLloydLibrary,Cincinnati,OH.JNPremainsto-dateastheofficialASPpublication.Duringthisperiod,thenumberofpaperspublishednearlydoubledfrom65in1977to116in1980.In1978,theNewslettereditedbyRalphBlomsterwasreformattedtoincludefivesections,andin1979,RegionalCorrespondentsinAfrica(Sudan),Europe,theUnitedKingdomandtheUnitedStateswereappointed.GuidelinesforthenominationandelectionofHonoraryMemberswereestablished in1977,andtheHonoraryMembershipReviewCommitteewasconstituted in1978. In1980,criteriaforevaluationofthequalificationsofpotentialnewmemberspriortoacceptancewereproposed.DuringthisfiveyearperiodtheAdHocBotanicalCodexCommitteeunderthechairmanshipofNormanFarnsworthwasveryactiveinreviewingthe scientific information available for a select number ofwidely used botanicalswith a view to the preparation ofmonographs,andtheChairpersonmetwithofficialsoftheFoodandDrugAdministrationtodiscusstheissues,andthepossibilityofobtainingfundingfortheproject.Inretrospect,theSocietywas20yearsaheadofitstimeinrecognizingthepotentialimpactofherbalmedicine(botanicaldietarysupplements)intheUS,foritwasexactlytwodecadeslater(1996)thattheCongressenactedtheDietarySupplementsHealthEducationAct(DSHEA)forregulatingthecommerceanduseofbotanicals.TheBotanicalCodexwouldhaveservedtheAmericanpublicwell.Furtherdetailsabouttheaboveissuesareprovidedundertheannualreviews,andthelistofofficerswhoservedinleadershippositionsisgivenintheTableabove,whichalsoincludesthelocationoftheannualmeetingsandfiguresrelatedtomembership,numbersofpaperspublishedinthejournal,andannualbudgets.
ASP Meetings, Officers and Statistics: 1976-1980
ASP Officers, etc. 1976 1977 1978 1979 1980
Annual Meetings Location TelemarkLodgeCable,WI
OlympicHotelSeattle,WA
Univ.OklahomaStillwater,OK
PurdueUniv.WestLafayette
Fac.deMedicineStrasbourg
President PhilipCatalfomo GeorgeConstantine HeinzFloss HarryFong JamesRobbersSecretary JackWeir JackWeir JackWeir JackWeir LarryRobertsonTreasurer LeeSchramm LeeSchramm LeeSchramm LeeSchramm LeeSchramm
Exec. Comm election PaulSchiff JohnRosazza MichaelEdwards John Cassady John CassadyAGM Chr John Cassady LynnBrady GeorgeWaller JamesRobbers Prof.Anton
AGM Program Chr GordonSvoboda LarryRobertson PaulSchiff C.J.Chang HeinzFlossLloydia Ed. ArtSchwarting JackBeal JackBeal
J. Nat. Prod. Ed. JackBeal JackBealNewsletter Ed. RalphBlomster RalphBlomster RalphBlomster RalphBlomster RalphBlomster
Auditing PhilipBabcock AlbertAwad AlbertAwad JosephKnapp WilliamKellerAwards/Funds GeraldSullivan GaryElmer MarilynSpeedie MarilynSpeedie MarilynSpeedie
Constitn/By-laws PaulSchiff JohnRosazza Robert Dobberstein RobertKrueger TedNettletonHon. Mem Com Chr GordonSvoboda LynnBrady
Membership GeorgeConstantine HeinzFloss HarryFong JamesRobbers JackWeirNominations DavidCarew DavidSlatkin GeorgeHatfield JimDusenberry GeorgeConstantine
Patron membership AlvinSegelman AlvinSegelman AlvinSegelman AlvinSegelman AlvinSegelmanPublicity Comm Carlton Turner Carlton Turner DavidSlatkin DavidSlatkin DavidSlatkin
Resolutions JosephSchradie FrankO’Connell JackWeir J.Schradie PeterHeinsteinASP New Members 30 68 78 83 91
ASP Members 314 368 353 428 487ASP Assets $34,874 $42,413. $59,121 $54,851 $56,318
Lloydia Papers 65 89 106J. Nat. Prod. papers 122 116
Hon member elected - - - - -
Excerpts from the ASP Anthology
continued on page 9
The ASP Newsletter Vol. 45(2) 9
ASP HISTORY: 2001-2005Nicholas H. Oberliesa and Jim McAlpineb
aNatural Products Laboratory, Research Triangle Institute, North Carolina 27709, and bThallion Pharmaceuticals Inc., Montréal, Québec, H4S 2C8.
1. Introduction During2001-2005theSocietyenjoyedasteadygrowthinmembershipandstatureintheacademiccommunity.Theconstitutionandby-lawsoftheSocietywererevisedandFellowshipsoftheSocietywereestablishedtorecognizesustainedresearchachievementinthescience.Whereastheannualduesremainedconstantat$35for12years,Societyyearlyexpensesmorethandoubledfrom$343,000to$770,000inthis5yearperiodalone.ThiswasmadepossiblebytransferpaymentsfromtheAmericanChemicalSocietyasASP’sshareoftheprofitsfromtheJournal of Natural Products (JNP).However ithadalso involvedconsiderable inroads intotheSociety’sreservesandattheendofthisperiodtheTreasurerwaswarningthatanincreaseindueswouldbenecessary,andthiswasimplementedinthe2005AnnualBusinessmeeting.Nevertheless,whilethenetassetsfluctuated,theassetsoftheASPFoundationasrecordedateachmidyearrosesteadilyfrom$298,393to$472,388.ThisincreasewasduetothetransferofsomeoftheJNPprofitsfromthegeneralfunds,aswellasdonationstotheFoundationbyanincreasingnumberofmembers.TheJournal of Natural Products, theofficialASPpublicationproducedincollaborationwiththeAmericanChemicalSociety,continuedtogrowinstature,whilenotchangingsignificantlyinthenumberofmanuscriptspublished;howeverthenumberofmanuscriptssubmittedcontinuedtoclimbfrom639in2000to727in2005,butthiswasoffsetbyareductionintheacceptanceratefrom71%to65%.TheImpactFactoroftheJournalrosefrom1.737in2001to2.267in2005andthetotalnumberofcitesofJNP articlesalmostdoubledfrom5.665to9,928.TheSociety’squarterlyNewsletterwaspublishedasa16pageglossyeditionwithreligiouspunctualityinaveryattractiveformat,andalthoughthiswasadmiredbyvirtuallytheentiremembership,thecostofproducingandmailingitwasraisingquestionsofamovetoelectronicformatanddistribution. DuringtheseyearsanadhoccommitteeonanASPTaxusHistoricalMarkerwasestablishedundertheleadershipofJohnBeutler.TheimpetusforthiscamefromsomearchivesearchingthatJohnandTomMcCloudhaddoneontheoriginofthe Taxus brevifoliabarksamplefromwhichMonroeWallandMansukhWanihadisolatedthefirstsampleofTaxol.GreggDietzmannundertookaliaisonwiththeUnitedStatesForestServiceandJohn,Tom,GreggandthetwoauthorsofthissectionscouredasectionoftheTatooshmountainsjustpriortotheSeattleMeetingin2000toscopeouttheactualsiteofthecollection.Itturnedouttobevirtuallyimpossibletofindtheoriginalcollectionsite(nearPackwood,Washington),astheroadsintheareahadbeenchangedafterMt.St.Helenseruptedin1980.Moreover,intheareawheretheoriginalcollectionwaspostulated,itwasratherdifficulttofindanystandsofTaxus.Atlast,theteamfoundasuitablesiteforaplaqueinthenearbyLaWisWiscampgrounds.JohnandGordonCraggarrangedforamemorialbrassplaquetobeerectedthere,whichissurroundedbyseveralchoiceTaxustrees.ItwasdedicatedonAugust22,2002,40yearstothedayaftertheoriginalcollection,andjustoveramonthafterMonroeWallpassedawayonJuly3,2002.MansukhWaniwasabletoattendtheceremonyanddeliveredamovingdedication.Aspartofthissamecommittee,NickOberliesspearheadedanefforttohavetheNaturalProductsLaboratoryatRTInamedaNationalHistoricChemicalLandmarkbytheAmericanChemical Society. This effort was championed by the local section of the American Chemical Society, which held adedicationceremonyinApril2003.1SeveralmembersoftheASPwereinattendance,andJohnCardellinaasPastPresidentdeliveredcommentsonbehalfoftheASP. Highlightsofeachof theparticular year’sactivitiesandaccomplishmentsareoutlinedafter this table,whichsummarizesseveralkeyofficesandparameters,hopefullyinaneasyaccessmode.
2. 2001 42nd Annual Meeting in Oaxaca, Mexico, July 14-18. TheSociety’sAnnualMeetingthisyearwasheldattheFortinPlazaandMissiondelosAngeleshotels.ThehistoricalcenterofOaxacaisaUNESCOCulturalHeritageofMankindsite.Themeetingattracted452participants,including121grad students.The focuswasonbiologicalproperties, isolationand structuralelucidationofnaturalproducts fromawidevarietyofsources.ChairedbyRaulE.Habib,ablyassistedbyRachelMataandRogelioPereda-Miranda,themeetingfeatured4symposiawith17invitedlectures,42contributedoralpresentationsand268posters.Notsurprisingly,therewasahighlevelofparticipationfromscientiststhroughouttheLatinAmericanworld.TheASPResearchAchievementAwardwaspresentedtoTomMabryandtheMattSuffnessYoungInvestigatorAwardtoBradleyMooreeachofwhichaddressedthemeetingontheirresearchachievements.ThemeetingincludedavisittoanothernearbyUNESCOWorldHeritageCenter,MonteAlbán,thearcheologicalremainsofwhathadbeenthecenteroftheZapoteccivilizationforapproximately1000yearsfrom500BCandoneoftheearliestcitiesinMesoamerica.Membersenjoyedagamutofgastronomicdelights
continued from page 8
Excerpts from the ASP Anthology
continued on page 10
The ASP Newsletter Vol. 45(2) 10
startingwithanopeningreceptionattheHotelMissiondelosAngelesonSaturdayevening,aMexicanbuffetduringapostersessiononSundayeveningfollowedbyLaGuelaguetza(aregionalOaxacanparty),aCalendasNightonTuesdayfollowedbyanOaxacanbuffetattheSantoDomingoConvent,andabanquetonWednesdayattheHotelFortinPlaza.Ofallofthese,thepartyattheConventwasthemostmemorable,withaparadeandfireworksanddancingthatwentonforseveralhours.Atthismeeting,NickOberliesandMelanyPuglisiorganizedthefirstYoungerMembersCommitteeCareerMixersasanicecreamsocial,aneventwhichhasbeenperpetuatedeversince.DeceasedmembersrememberedwereDrs.RichardSchultes(Honorarymember),HoonHuhandHirata.
ASP Meetings, Officers and Statistics: 2001-2005ASP Officers, etc. 2001 2002 2003 2004 2005
Annual Meetings Location
HotelsFortinPlaza&MissiondelosAngeles,Oaxaca,
Mexico
HyattRegencyHotel,New
Brunswick,NJ
Carolina Inn and MoreheadPlanetarium
ChapelHill,NC
WestinKierlandResort&SpaPhoenix,AZ
OregonStateUniv.Corvallis,OR
President John Cardellina II BillPelletier BillGerwick Jon Clardy JimMcAlpineSecretary BillKeller BillKeller BillKeller BillKeller BillKellerTreasurer DavidSlatkin DavidSlatkin DavidSlatkin DavidSlatkin DavidSlatkin
Exec. Comm TedMolinski RayAndersen BillBaker Ching-jerChang PhilCrewsAGM Chr RaulEHabib RameshPandey NickOberlies DavidSlatkin MarkZabriskie
AGM Program Chr RachelMata RenuMisra CedricPearce PedroChavez BillGerwickJ. Nat. Prod. Ed. DougKinghorn DougKinghorn DougKinghorn DougKinghorn DougKinghorn
Newsletter Ed. JoyReighard JoyReighard&RenuMisra RenuMisra RenuMisra RenuMisra
Website Chair JohnBeutler JohnBeutler JohnBeutler JohnPorter JohnPorter
Auditing TedMolinski TawnyaMcKee JonAnderson JonAnderson NormanFarnsworth
Awards/Funds BillGerwick BradDavidson BradDavidson TawnyaMcKee PhilProteauConstitn/By-laws KathyGloer RoyOkuda PedroChavez PedroChavez NickOberlies
Hon. Memb Com Chr Chris Ireland JimMcChesney Chris Ireland JimMcChesney John Cardellina IIMembership BillPelletier BillGerwick Jon Clardy JimMcAlpine BillFenical
Foundation Chair John Cassady John Cassady John Cassady John Cassady John CassadyFoundation Treas. RobertKrueger RobertKrueger RobertKrueger RobertKrueger RobertKrueger
Nominations JimGloer John Cardellina II BillPelletier BillGerwick Jon ClardyRAA Committee Chr JohnPezzuto DavidKingston FrancisSchmitz JimGloer JimGloer
Publicity Comm BarryO’Keefe BarryO’Keefe BarryO’Keefe JohnBeutler JohnBeutlerResolutions CedricPearce FrankO’Connell CedricPearce BillBaker PedroChavez
ASP New members 108 90 122 145 125ASP Members* ~1200 ~1200 ~1180 ~1200 ~1200
ASP Assets $206,821 $243,637 $239,267 $338,803 $197,394Foundation/midyr $298,393 $358,411 $353,876 $401,018 $472,388
J. Nat. Prod. Papers 397 430 370 437 385RAA Awardees TomMabry RichardMoore JohnFaulkner† Jon Clardy BillFenical
Hon Memb Elected - GordonCragg HarryFong DavidSlatkin John Cassady* These numbers are estimates since the number of lapsed members in the previous year was unknown, but totalmembershipnumbershavehoveredaround1200forseveralyears.
Excerpts from the ASP Anthologycontinued from page 9
1923, Aug. 29- The SeedThe first Plant Science Laboratory Seminar, University of Minnesota. Founder and first Chair – Edwin L.
Newcomb.
1958Arthur Schwarting, Chair, 35th Seminar, Ferris
Institute, Big Rapids, MI, proposes reorganization of the Seminar to be renamed the American
Society of Pharmacognosists. Norman Farnsworth chairs committee to study proposal and revise
Constitution and By-Laws.
1959, Aug 10- The Birth of the ASP36th Seminar, University of Illinois at Chicago. Revised
Constitution and By-Laws organizing the American Society of Pharmacognosy approved.
1959, Nov. First Officers and CommitteesPresident Varro Tyler; Vice-President Norman Farnsworth; Secretary Frank Mercer; Treasurer Frank Crane; Executive Committee,
Edward Claus, Carl Johnson, David Carew.
1960, June 30-July 21st Annual Meeting, Boulder, CO. Lloydia becomes the official journal, Editor Arthur Schwarting. Society becomes incorporated.
1961, June 19-212nd Annual Meeting, Houston, TX. Varro Tyler and Norman Farnsworth, the first and only members to serve two years as President and Vice-President, acknowledged for their outstanding leadership in founding and
developing the ASP.
1964, June 22-235th Annual Meeting, Pittsburgh, PA. President Svoboda chairs “Symposium on the Chemistry and Biological Activity of Catharanthus, Vinca and related Alkaloids” and the Farnsworth-
concocted brew, “Vincatini”, is initiated.
1965, June 15-186th Annual Meeting, Kingston, RI. ASP Newsletter officially approved as a permanent publication - Mel Gibson as
Editor.
1969, Aug. 18-2210th Annual Meeting, Corvallis, OR. First marine theme. “Symposium on Marine
Biomedicinals.”
1970, July 27-3111th Annual Meeting, 1st Joint
Meeting with GA, Vienna, Austria.
1971, Sept. 7-1212th Annual Meeting, Joint Meeting with 31st International Congress of Pharmaceutical Sciences, Washington, DC. Amalgamation with the Pharmacognosy and Natural Products Section of the Academy of Pharmaceutical Sciences (AphA) first proposed in 1967,
defeated by ASP membership in mail ballot.
1974, Aug. 3-815th Annual Meeting, Chicago, IL.
Official ASP Logo selected.
1975, July 27-Aug. 216th Annual Meeting, 2nd Joint Meeting with GA, Storrs, CT. Ad Hoc Botanical Codex Committee appointed to consider ASP involvement in
establishing a Botanical Codex.
1979, July 29-Aug. 320th Annual Meeting, West Lafayette,
xedoC lacinatoB a fo noitacilbuP .NIsuspended due to lack of funding by the FDA. Lloydia offically renamed “Journal of
Natural Products (Lloydia).”
1980, July 6-1121st Annual Meeting and 1st Joint Meeting with GA, PSE, and the
AFEMM, Strasbourg, France.
1981, July 12-1722nd Annual Meeting, Boston, MA. David Slatkin elected as Treasurer, a position
he continues to fill to this day!
1983, July 24-2824th Annual Meeting, Oxford, MS. Jim Robbers takes over as Editor of JNP from
Jack Beal who served from 1977.
1985, July 7-1226th Annual Meeting, Joint Meeting with GA, PSE and AFEMM, Chapel Hill, NC. William Keller elected as Secretary, a position he continues to hold today! Koji Nakanishi selected as the first ASP
Research Achievement Award recipient.
1988, July 17-2129th Annual Meeting, Joint Meeting with Japanese
Society of Pharmacognosy, Park City, UT.
1990, July 17-2231st Annual Meeting, Joint Meeting with GA, PSE, and AFERP, Bonn, Germany.
ASP Foundation Board established.
1994, July 31-Aug. 435th Annual Meeting, Joint Meeting with GA, PSE and AFERP, Halifax, Nova Scotia, Canada. The ASP Executive Committee unanimously supported the joint venture
.PNJ hsilbup-oc ot yteicoS lacimehC naciremA eht htiwDouglas Kinghorn takes over as Editor.
1998, July 19-24 39th Annual Meeting, Orlando, FL. John Cassady appointed as permanent chair of the ASP Foundation.
2001, July 14-1842nd Annual Meeting in Oaxaca, Mexico. A highly successful meeting hosted by our neighbors; featured
the first Young Members Committee Career Mixer.
2002, Aug. 22A plaque commemorating the collection of Taxus brevifolia, source of Taxol, was dedicated
at La Wis Wis Campground, WA.
2005, July 23-2746th Annual Meeting, Corvallis, OR. Norman Farnsworth received the ASP Research Achievement Award which was renamed the Norman Farnsworth Research
Achievement Award in his honor.
2006, Aug. 5-9 47th Annual Meeting, Arlington, VA. A special award presented to Maureen Rouhi, Managing Editor, Chemical and Engineering News, in recognition of her sustained
efforts in reporting on natural products research.
2008, August 3-8. 49th Annual Meeting, Joint Meeting with GA, PSE and
AFERP, Athens, Greece.
The ASP Newsletter Vol. 45(2) 12
The2008winnersoftheArthurE.SchwartingandJackL.BealAwardshavebeenannounced.Thepaperentitled,“DeterminationoftheabsoluteconfigurationsofnaturalproductsusingTDDFTopticalrotationcalculations”byauthorsPhilipJ.Stephens,JohnJ.Pan,F.J.Devlin,andJamesR.Cheeseman,hasbeenawardedtheSchwartingAward.ThewinneroftheBealAwardis,“IsolationandstructuraldeterminationofmalevamideE,adolastatin14analogue,fromthemarinecyanobacteriumSymploca laete-viridis”byBeatriceAdams,PeterPörzgen,EmilyPittman,WesleyY.Yoshida,HansE.Westenburg,andF.DavidHorgen. In2001,theFoundationBoardoftheAmericanSocietyofPharmacognosybegananewinitiativeasaresultoftheArthurE.SchwartingandJackL.BealAwardsforbestpapersintheJournal of Natural Products (JNP).Inthismanner,twoformerdistinguishededitorsofJNParefondlyremembered.TheSchwartingAwardisopentoallpaperspublishedinJNPwithinagivenyear(eitherinprintorelectronically).Inturn,theBealAwardisawardedtoyoungerinvestigators[i.e.,personswithin12yearsofreceivingtheirPh.D.degreeorwithin10yearsofgainingtheirfirstprofessionalappointmentsuchasanAssistantProfessororanequivalentpositioninindustryorgovernment]. Atwo-tierprocesswasusedtodeterminethewinnersforpaperspublishedinJNP in 2008, with editors Daneel Ferreira,WilliamH.Gerwick,A.DouglasKinghorn,andRichardG.Powellhavingnominated twopaperseach for theSchwartingAwardandoneeachfortheBealAward.ASPPresidentGuyCarterthenappointedanadhoccommittee,BenShen,Chair,BarbaraTimmermann,andShmuelCarmeli,tomakethefinalselections. ThecorrespondingauthorsofthesepaperswillbeinvitedtoattendtheBanquetatthe50thAnnualMeetingoftheAmericanSocietyofPharmacognosyinHonolulu,Hawaii,June27-July1,2009,toreceiveacheckandaplaqueinhonorofthisachievement.Theabove-mentionedpapersmaybeaccessedfreelyfromthehomepageoftheJournal of Natural Products at http://pubs.acs.org/JNP.CongratulationstoDrs.StephensandHorgenandtotheirco-authors!
2008 Schwarting and Beal Awards for Best Papers in JNPbyDr.A.DouglasKinghorn
ThememorialserviceforthelateDr.JackK.WiertookplaceonWednesday, May 13, at 2 p.m. in the Randolph Few Chapel atCroasdaileVillageinDurham,NorthCarolina.Dr.Wierpassedawayatage85attheDukeUniversityHospitalSunday,December21,2008.
Dr.WierwasborninCairo,Nebraska,onAugust31,1923.HeservedintheNavyduringboththeSecondWorldWarandKoreanWar.AfterhisserviceheearnedhisB.S.inPharmacyfromtheUniversityofNebraskain1958.HethenwenttotheUniversityofWashingtonforhisgraduatestudies,andheobtainedhisM.S.andPh.D.degreesinPharmacognosy,completedin1959and1961,respectively,underthementorshipofDr.Varro(Tip)Tyler.
AchartermemberoftheASP,Dr.Wierservedassecretaryin 1970-1979, then as ASP President from 1980-1981. Dr. Wier alsochairedtheASPLocalProgramCommitteetwicewhenhehostedtheAnnualMeeting at theUniversity ofNorth Carolina in 1961 and anInternationalMeetingin1985.
In1961,Dr.WierstartedhisteachingcareerattheUniversityofNorthCarolina,risingthroughtheranksuntilheretiredin1987.InadditiontobeingapopularteacherandprepharmacycounselorattheUniversityofNorthCarolina,Dr.WierwasthecomputerexpertfortheCollegeofPharmacyintheearly1980s,andhewasresponsiblefortheintroductionofcomputersintothestudentrecordsystem.
Dr.Wierissurvivedbyhiswife,Dixie,ofCroasdaileVillage,Durham,NorthCarolina.TheWierfamilyrequeststhatmemorialsbegiventotheAlzheimer’sFoundationofAmericaoracharityofyourchoice.
Dr. Jim Robbers and Mrs. Varro Tyler contributed to this article.
In Memoriam: Dr. Jack K. WierbyMs.AmyKeller
The ASP Newsletter Vol. 45(2) 13
ASP Transfers Archives to Lloyd Library
Lloyd Library and Museum and American Society of Pharmacognosy (ASP) Announce the Agreement for the Transfer of ASP Archives to the Lloyd Library and
Museum, Historical Research Center for the Natural Health Movement
AmericanSocietyofPharmacognosyleadersandtheLloydLibraryandMuseum,undertheleadershipofDirectorMaggieHeran,recentlyfinalizedanagreementtotransferthearchivesoftheASPtotheLloydLibrary,tomaketheLloydLibrarythepermanentsitefordepositofSocietymaterials,andalsotoencourageASPmemberstodeposittheirpersonalpapersattheLloydLibrary.TheLibraryalreadyholdsthepapersofVarro“Tip”TylerandNormanR.Farnsworth,bothwell-knownpharmacognosistsandfoundingmembersoftheASP.TheLibraryisalsotherepositoryfornotedpharmaceuticalchemistGeorgeRieveschl,Jr.,theinventorofBenadryl.Inadditiontobooks,papersandphotographs,theLibrarycollectsrelatedhistoricalartifacts,fromoldpharmaceuticalbottles,especiallythoseoftheLloydBrothers,Pharmacists, Inc.,microscopesandchemicalscales,tolargeritems,suchastherecentlyacquiredlargeSoxhletextractor,animportanttoolintheextractionofTaxolcourtesyoftheeffortsofNickOberliesfromResearchTriangleInstitute. TheAmerican SocietyofPharmacognosywas formed in1959asanoutgrowthof thePlant ScienceSeminars,withTipTylerservingastheorganization’sfirstpresident.Itsgoalwastocreateaforumfortheexchangeofideasandresearchadvancesamongpharmacognosists,agoalwhichitcontinuestofulfill50yearslater.ArchivalmaterialsareslatedfortransfertotheLloydLibraryintheupcomingyear,aspartoftheASP50thAnniversarycelebration.OtheractivitiesoftheASPinconnectionwiththeanniversaryincludepublicationofabook,“TheAmericanSocietyofPharmacognosy.50YearsofProgressinNaturalProductsResearch,1959-2009,”andtheannualmeetingofthesocietyinHonolulu,Hawaii,inJuneofthisyear.ThisagreementpresentsanopportunityforallcurrentandformermembersofASPwhomaybeholdinghistoricalmaterials to forwardthemtotheLloydLibrary for inclusion intheASParchivalholdings.TheLloydLibraryarchivalstaffwillsortandorderallmaterials,makingafindingaidavailableonline,forresearcherusearoundtheworld. TheLloydLibraryanditsHistoricalResearchCenterfortheNaturalHealthMovement,launchedin2008,seekstocollecthistoricalmaterials,books,journals,andarchivalmaterials,thatdocumentthegrowthandchangeswithinthenaturalhealthmovement,includingthedevelopmentofdrugsfromnaturalsources. Ingeneral,theLibraryholds,acquires,preserves,andprovidesaccesstobothhistoricandcurrentbooksandjournals,aswellasarchivalmaterials,onawidevarietyofdisciplinesthatfallunderthesubjectsofnaturalhistory,botany,pharmacy,andmedicine.Lloyd’sresourcesareinfactaneclecticblendofahostofrelatedsciences.Despitethescientificfocus,thecollectionshaverelevancetothehumanities,suchasvisualartsandforeignlanguagesthroughresources that feature botanical illustrations, original artworks, and travel literature. The collection consists of over200,000volumes,withtheearliestvolumedatingfrom1493tothemostcurrentpublishedresearchinthefieldsofnaturalmedicine,botany,andpharmacy.TheLloydisopentothepublicandweinviteyoutoexplorethisuniqueestablishment.
ContactsJohn A. Beutler 301-846-1942
Maggie Heran 513-721-3707
WebsitesASP
www.phcog.org
Lloyd Librarywww.lloydlibrary.org
The ASP Newsletter Vol. 45(2) 14
March 2009 Issue of JNP Honors Dr. Kingston
TheMarch2009issueoftheJournal of Natural ProductswasdedicatedtoDr.DavidG.I.Kingston,ASPFellow,tohonoraprolificanddistinguishedcareerinnaturalproductchemistry.Thehonoraryissuecontains21fullarticles,11notes,eightcontributedreviews,twoinvitedreviews,andaneditorialtributefromtwoASPmembersDrs.VanderlandaS.BolzaniandDavidJ.Newman,togetherwithDr.A.A.LeslieGunatilaka.
Dr. Kingston noted, “I was very pleased and honored tobe selected for the celebratory issue, and I am grateful to DougKinghorn, Deneel Ferreira, Richard Powell, and Philip Proteau,together with the special editors Leslie Gunatilaka, Vanderlan Bolzani,and David Newman for their hard work in putting this together.” AccordingtoDr.Kingston,“Thecontributionsareallhighqualityones, with many of the leading names in natural products researchrepresented among the authors. I was pleased with both the numberandqualityof thesecontributions.Almostall themainauthorsaregoodfriendsofmine,andIhaveworkedwithsomeoftheminthepast.JamesSnyderandSidneyHechtrepresentthose Ihavecollaboratedwith,whileVanderlan Bolzani, Leslie Gunatilaka, Gulacti Topcu, Gerald Hammond,Shu-Wei Yang, and Chang-Yih Duh all spent time in my laboratory.” BornonNovember9,1938,Dr.KingstonreceivedaB.A.inChemistry
fromCambridgeUniversityin1960.Dr.KingstonalsoearnedaB.S.andPh.D.fromCambridgein1963,onthechemistryofaphidpigments.From1963-1964,heservedasResearchAssociateinBiochemistryatMassachusettsInstituteofTechnology,andin1966becameanAssistantProfessorattheStateUniversityofNewYork,Albany.HeeventuallymovedtoBlacksburg,Virginia, tobeAssociateProfessorofChemistryatVirginiaPolytechnic InstituteandStateUniversity.HebecameFullProfessorin1977,andUniversityDistinguishedProfessorin1999.
Dr.Kingstonauthoredorco-authoredalmost330scientificpublications,30bookchapters,16patentapplications,andajointlyeditedbookwithASPmembersDrs.GordonCraggandDavidNewman.Notably,Dr.Kingstonworkedonstructure-activityrelationshipsofpaclitaxel,andwaslastyear’srecipientoftheErnestGuentherAwardfromtheAmericanChemicalSociety. Whenaskedwhatliesaheadforpharmacognosy,Dr.Kingstonreplied,“Naturalproductsdrugdiscoveryhasauniqueadvantageoverothermethodsofdrugdiscoveryinthatnaturalproductshaveanevolutionaryhistory,andareuniquelydesigned to interactwith various receptors.The futureofnaturalproducts researchwill depend inpartontaking advantageof the tools ofmodern genetics tomanipulate species toproduce crypticmetabolites that arenotexpressedundernormalcultureconditions.Thisapproachislikelytoyieldawiderangeofnewnaturalproducts,someofwhichwillmostprobablybecomedrugsintheyearsahead.Thiswillmostlikelymeanadecreasedemphasisonplantproducts, since geneticmanipulation of plants is difficult, and an increased emphasis onmicrobial natural products.However,as thetools forgeneticengineeringofplants improve, it ispossible thata similarapproachcouldwork forplants inthefuture.Theuseofmicrobialspecieshasagreatadvantage,however,thatonceanorganismandcultureconditions have been identified it is possible in principle to produce unlimited amounts of the desiredmetabolite.” AsforthefutureoftheJournal of Natural Products,Dr.Kingstonmentioned,“TheJournal of Natural Products is thepremierjournalinitsfield,andIdonotseethischanginginthefuture.UnderDougKinghorn’sableleadershipithasgrowninqualityandimpactfactoreveryyearforthelastseveralyears.Ithastheadvantageofcoveringthewholefieldofnaturalproducts,frommicrobial,marine,andplantsources,aswellassyntheticandbiosyntheticstudies.Thisbreadthofcoveragewillkeepitwellpositionedtoretainitsleadershiproleasthedisciplineofnaturalproductsresearchgrowsandmatures.”
Drs. Vanderlan da S. Bolzani, A. A. Leslie Gunatilaka, and David J. Newman contributed to this article.
byMs.AmyKeller
Dr.KingstonlecturingatVirginiaTech.
The ASP Newsletter Vol. 45(2) 15
Conference Calendar
The Newsletterispleasedtoannouncethefollowingupcomingconferencesandmeetings.TheeventsportrayedherereflectwhatlistingsandnoticestheNewsletterhasspecificallyreceived.Foramoreextensivecalendar,pleasevisittheASPwebsiteatwww.phcog.org.Ifyouhaveaconferenceoreventyouwouldlikementioned,pleasesendusrelevantinformation,includinganygraphicsorappropriatefliers,[email protected].
9th International Herb Symposium
WheatonCollege,Norton,MassachusettsJune 19-21, 2009
www.internationalherbsymposium.com/index.html
57th International Congress & Annual Meeting of the Society for Medical Plant
Research
Geneva,SwitzerlandAugust16-20,2009
www.ga2009.org
6th Conference on Medicinal and Aromatic Plants of Southeast European
Countries
Antalya,TurkeyApril18-22,2010
www.6thcmapseec.org
50th Anniversary Meeting of the American Society of Pharmacognosy
Honolulu, HawaiiJune 27 - July 2, 2009
www.phcog.org/AnnualMtg/Honolulu.html
Center for Marine Natural Product Drug Discovery Symposium
Seoul,KoreaSeptember16-18,2009
www.cmdd.re.kr/english/
The ASP Newsletter Vol. 45(2) 16
Behind the Scenes in Pharmacognosy
IntheMarch2009Journal of Natural ProductshonoraryissuetoDr.DavidG. I.Kingston,thearticleentitled,“Quassinoid inhibitionofAP-1functiondoesnotcorrelatewithcytotoxicityofproteinsynthesis inhibition”byJohnA.Beutler,Moon-IlKang,FrancisRobert,JasonA.Clement,JerryPelletier,NancyH.Colburn,TawnyaC.McKee,EkaterinaGoncharova, James B. McMahon, and Curtis J. Henrich, was published. TheNewsletter interviewed first author andASPmemberDr.JohnBeutler,whotooktimeouthisbusyscheduletogiveusinsightintothoseuniquecompounds,thequassinoids.
How did you become interested in the bioactivity of quassinoids? WescreenedbothpurecompoundsandplantextractsinanassayforinhibitorsoffunctionofthetranscriptionfactorAP-1.ThereweretwopurequassinoidsfromtheNCIrepositorywhichwereactive,andabunchofplantextracts fromtheSimaroubaceae,theonly familyknowntomakethistypeofcompound.
Who in your laboratory carried out the research? ScreeningwasdonebyaJohnsHopkinsmaster’sstudent,Ms.KatieRuocco,whoworkedinDr.NancyColburn’slabandthencameupstairstoruntheassay.AKoreanpostdoc,Dr.Moon-IlKang,inNancy’slab,didmostofthedetailedcharacterizationofthecompounds,quassinoidsandotherwise.Dr.JasonClement,apostdocandformergraduatestudentofDr.DavidKingston,bothASPmembers,didbioassay-guidedfractionationofanextractunderfellowmemberDr.TawnyaMcKee’sguidance.Whenwerealizedthatweneededbackupintheareaofproteinsynthesis,IcontactedDr.JerryPelletieratMcGill,andhispostdoc,Dr.FrancoisRobert,ranassaystoinvestigatethataspectofthings.Iwasthetrafficcop,organizer,andmanuscriptdrafter.
Could you provide a brief explanation of the work and results in your own words? In what way are the data in your paper new? AparticularsubsetofquassinoidsappearedtoblockthefunctionofthetranscriptionfactorAP-1.Thenoveltywasinidentifyingafewquassinoidsthatseemtohaveadifferenteffectoncellsthantheverycytotoxiconeswhichwentthroughclinicaltrialsmanyyearsago.
What impact does this research have from a health perspective? It is hard to say at this time. Severalwell-knownquassinoids failed in clinical trials years ago. It is not clearthatproteinsynthesis inhibitorsaregoingtobeusefuldrugsforcancer.ASPmemberDr.JohnPezzuto’s labexploredquassinoidsafewyearsagoandfoundnewbiologicalactivities.Thebasicpointofthepaperisthatquassinoidsprobablydoseveralthingsbesidesinhibitingproteinsynthesisinanonspecificway.Ifwecanteasethoseothermechanismsawayfromproteinsynthesisinhibition,wemayhavemoreusefuldrugcandidatestotestincancer.
What is a favorite nonscientific activity of your lab? Paintball,picnics,andtheoccasionalhikeontheAppalachianTrail.
What is your lab’s motto? Arandomsayingthatfounditswayontothechalkboardinthelabwas,“Onceinarowisn’tenough.”Meaning,youhavetorepeataresulttohaveanyconfidenceinit.
What is your greatest extravagance in the lab? Governmentemployeesdonothaveextravagances!
The Curious QuassinoidsbyMs.AmyKeller
Dr.JohnBeutler
The ASP Newsletter Vol. 45(2) 17
From The Archives
Welcome to Lynn, Massachusetts
Pharmacognosyhashadmanyfirsts,butoneof themostunusual,probablyeligible for“Ripley’s Believe it or Not”isthefactthatLynn,Massachusetts,ahistorictownontheNorthShoreabout10milesfromBoston,washometofiveaccomplishedpharmacognosistswhoallattendedtheMassachusettsCollegeofPharmacy(MCP).Onecan’thelpbutask,whatwasitabouttheteachingofDrs.HeberYoungkenandMaynardQuimby?MembersofthisuniquegroupareASPmembersDrs.RalphBlomster,retired,CollegeofPharmacy,UniversityofMaryland,Baltimore,Maryland,NormanFarnsworth,CollegeofPharmacy,UniversityofIllinois,Chicago,Illinois,andGeorgiaPersinosBergstromPerdue,whowasExecutiveDirector forNaturalProductsLaboratories,Rockville,Maryland,andEditorandPublisherof thenewsletterWashington Insight,whereshecontinuesasEditorandconsultant.AlsoattendeesofMCPareDrs.FranklinCole,retired,CollegeofPharmacy, IdahoStateUniversity,Pocatello, Idaho,andFrankO’Connell,SchoolofPharmacy,WestVirginiaUniversity,Morgantown,WestVirginia. Dr.FarnsworthalsoreceivedhisMaster’sdegreefromMCP, Dr. Cole his Ph.D., and Dr. Perdue both her Master’sand Ph.D. degrees. She had the distinction of being the firstwomantoreceiveaPh.D.atMCP,whichwasunheardforthatconservativeNewEnglandcollege. Firstsettledin1629,LynnwasnamedafterthetownofKing’sLynn,England,theoriginalhomeofthisAmericantown’sfirst minister, SamuelWhiting. It was originally a communitydevoted to agriculture and fishing and later became a townbasedonleathertanningandtheshoeindustry.ItisrecordedthatthefirsttanneryintheUnitedStateswasinLynnin1629,whileshoemakingbeganin1635. In1892thecity’sThomson-HoustonElectricCompanymergedwiththeEdisonElectricCompany,toformtheGeneralElectric Company (GE). GE continues to serve as a majoremployerinthiscityofover80,000. A resident of Lynn, Ms. Lydia Pinkham, developedmanynaturalproducthomeremediesthat laterbecamethefoundationforasuccessfulfamilybusinessin1875.Reportedly,one of her ingredients in one of hermost popular productsforwomen,LydiaE.Pinkham’sVegetableCompound,isblackcohosh.
Ms. Amy Keller contributed to this article.
byDr.GeorgiaPerdue
MapbyO.H.Bailey,1879,notdrawntoscale.
The ASP Newsletter Vol. 45(2) 18
FullMembershipFullmembership is open toany scientist interested in the studyofnaturalproducts.CurrentmembershipduesandJournal of Natural Products
subscriptionratescanbefoundatwww.phcog.org/meminfo.html.
AssociateMembershipAssociatemembership is open to students of pharmacognosy and allied fields only. Thesemembers are not accorded voting privileges. Current
membershipduesandJournal of Natural Productssubscriptionratescanbefoundatwww.phcog.org/meminfo.html.
EmeritusMembershipEmeritusmembershipisopentoretiredmembersoftheSocietywhomaintainedmembershipintheSocietyforatleastfiveyears.Currentmembership
dues and Journal of Natural Productssubscriptionratescanbefoundatwww.phcog.org/meminfo.html.
HonoraryMembershipHonorarymembers are selected by the Executive Committee of the American Society of Pharmacognosy on the basis ofmeritorious service to
pharmacognosy.
PresentHonoraryMembersare:•Dr.ArnoldR.Brossi,NationalInstitutesofHealth•Dr.DavidP.Carew,UniversityofIowa
•Dr.JohnM.Cassady,OregonStateUniversity•Dr.GeoffreyA.Cordell,NaturalProducts,Inc.•Dr.GordonC.Cragg,NationalInstitutesofHealth•Dr.NormanR.Farnsworth,UniversityofIllinoisatChicago
•Dr.HarryH.S.Fong,UniversityofIllinoisatChicago•Dr.JamesE.Robbers,PurdueUniversity•Dr.E.JohnStaba,UniversityofMinnesota
•Dr.OttoSticher,SwissFederalInstituteofTechnology•Dr.DavidJ.Slatkin,ChicagoStateUniversity•Dr.HildebertWagner,UniversityofMunich•Dr.MansukhWani,ResearchTriangleInstitute
AdditionalinformationaboutmembershipmaybeobtainedbywritingtotheTreasureroftheSociety:DavidJ.Slatkin,Ph.D,Treasurer,TheAmericanSocietyofPharmacognosy,3149DundeeRoad,#260,Northbrook,Illinois60062.Email:[email protected]
DavidJ.Slatkin,Ph.D,TreasurerTheAmericanSocietyofPharmacognosy3149DundeeRoad,#260,Northbrook,Illinois60062
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