The Basic Science of Periprosthetic Osteolysis*

by Michael J. Archibeck, Joshua J. Jacobs, Kenneth A. Roebuck, and Tibor T. Glant

J Bone Joint Surg AmVolume 82(10):1478-1478

October 1, 2000

©2000 by The Journal of Bone and Joint Surgery, Inc.

Radiograph demonstrating extensive osteolysis in the proximal part of the femur in a patient with a cemented total hip replacement.

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Photomicrograph of chromium orthophosphate hydrate-rich corrosion products around the rim of the bore of a cobalt-chromium-alloy femoral head that was coupled with a titanium-alloy stem

(× 7).

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Photomicrograph of chromium orthophosphate hydrate-rich corrosion products circumscribing the neck of a cobalt-chromium-alloy femoral component, just distal to the head-neck junction (×

5).

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Figs. 3-A and 3-B: Photomicrographs of polyethylene particles isolated from tissues, showing spheroids (Fig. 3-A) and clusters of finer particles with bridging fibrils (Fig. 3-B).

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Figs. 3-A and 3-B: Photomicrographs of polyethylene particles isolated from tissues, showing spheroids (Fig. 3-A) and clusters of finer particles with bridging fibrils (Fig. 3-B).

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Autoradiograph of Northern blot analysis, showing the expression of mRNAs for procollagen a1(I) and a2(III) in human MG-63 osteoblast-like cells incubated for forty-eight hours with various

particles at a concentration of 0.05 percent.

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Photomicrographs of periprosthetic interfacial tissue removed from patients with failed cementless (Fig. 5-A) and cemented (Fig. 5-B) total hip replacements.

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.

Photomicrographs of periprosthetic interfacial tissue removed from patients with failed cementless (Fig. 5-A) and cemented (Fig. 5-B) total hip replacements.

Michael J. Archibeck et al. J Bone Joint Surg Am 2000;82:1478

©2000 by The Journal of Bone and Joint Surgery, Inc.