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The Centrosome in Cell Replicatio nand Early Development
Robert E. Palazzo
Gerald P. Schatten
Contributors
xv
Preface
xix
1The Centrosome and Parthenogenesi sThomas Küntziger and Michel Bornens
I. Introduction
1II. Toward a Functional Description of the Centrosome
2III. The Centrosome Organelle versus Self-Assembled Centers
1 2IV. Centrosome Reproduction and the Parthenogenetic Activity of
the Centrosome
1 3V. Conclusion
1 8References
1 9
2 .y-Tubuli nBerl R . Oakle y
I . Centrosomes and Microtubule Nucleation
27II y-Tubulin and the Tubulin Superfamily of Proteins
30III. Distribution of y-Tubulin in Cells
3 3IV. Studies of y-Tubulin Function
39V. y-Tubulin and Microtubule Assembly : Current Knowledge and
Unanswered Questions
45VI. Concluding Remarks
4 9References
4 9
3y-Tubulin Complexes and Their Role in Microtubule Nucleatio nRuwanthi N. Gunawardane, Sofia B . Lizarraga, Christiane Wiese, Andrew Wilde,and Yixian Zheng
I. Introduction
5 5II. Biochemical and Structural Studies of yTuRC and yTuSC
57
III. Evidence That yTuRC Is the Major Microtubule Nucleator a tthe Centrosome
64IV. The Mechanism of Microtubule Nucleation
65V. Concluding Remarks
69References
7 0
4y-Tubulin of Budding YeastJackie Vogel and Michael Snyder
I. Introduction
7 5II. Tubulins of Yeast
8 0III. Interactions between Tubulins
88IV. The y-Tubulin Complex in Yeast
9 1V. Future Directions
9 5References
97
5The Spindle Pole Body of Saccharomyces cerevisiae : Architecture andAssembly of the Core ComponentsSusan E. Francis and Trisha N . Davis
I. Introduction
10 5II. SPB Duplication and Assembly of the Mitotic Spindle
10 6III. Structure of the SPB
107IV. SPB Core Components
109V. Assembly of the Core SPB Components
122VI. Transcriptional Regulation of Core SPB Components
123VII. Ilomologs of Spindle Pole Components i n
Other Organisms
124VIII. Future Directions
125References
128
6The Microtubule Organizing Centers of Schizosaccharomyces pomb elain M . Hagan and Janni Peterse n
L Introduction
13 3II . Cytoplasmic Microtubule Organizing Centers
136
III. The Spindle Pole Body
13 8IV. Molecular Characterization of SPB Components
14 9V. Perspectives
15 3References
15 4
7Comparative Structural, Molecular, and Functional Aspects of th eDictyostelium discoideum Centrosom eRalph Gräf, Nicole Brusis, Christine Daunderer, Ursula Euteneuer,Andrea Hestermann, Manfred Schliwa, and Masahiro Ueda
I. Introduction
16 1II. Comparative Morphology of the Dictyostelium Centrosome
163IT I . Comparative Analysis of Dictyostelium Centrosome Duplication
167IV. Comparative Molecular Biology of the Dictyostelium Centrosome
17 1V. Conclusions
17 9References
17 9
8Are There Nucleic Acids in the Centrosome ?Wallace F . Marshall and Joel L . Rosenbau m
I. Introduction
187II. Do Centrioles or Centrosomes Contain DNA?
188III. Do Centrosomes Contain RNA?
19 7IV. Conclusions
20 1References
20 2
9Basal Bodies and Centrioles : Their Function and StructureAndrea M . Preble, Thomas M. Giddings, Jr ., and Susan K. Dutche r
I. Introduction to Centrioles and Basal Bodies
20 7II. The Structure of Centrioles and Basal Bodies
212III. The Function of Basal Bodies and Centrioles as Revealed b y
Mutational Analysis
22 1IV. Basal Body/Centriole Replication
226References
228
16Centrosome Reduction during Mammalian Spermiogenesi sG. Manandhar, C . Simerly, and G. Schatte n
I. Introduction
343IL Overview of Mammalian Spermiogenesis
345III. Stages of Centrosome Reduction during Spermiogenesis
347IV. Conclusions
35 8References
35 8
17The Centrosome of the Early C. elegans Embryo : Inheritance, Assembly ,Replication, and Developmental RolesKevin F. O'Connell
I. Why C. elegans?
36 5II. Origin and Replication of the Zygotic Centrosomes
367III. The Central Role of the Centrosome-Pronucleus Complex in Specifyin g
AP Polarity
374IV. Nuclear Positioning
378V. Concluding Remarks
38 0References
38 1
18The Centrosome in Drosophila Oocyte Developmen tTimothy L . Megraw and Thomas C. Kaufma n
I. Introduction
38 5II. The Germarium : Centrosomes Are Anchored to Achieve Polarize d
Cell Divisions
387III. The Oocyte MTOC
39 1IV. Meiosis
396V. Summary 400
References
402
19The Centrosome in Early Drosophila Embryogenesi sW. F. Roth well and W. Sulliva n
I. Introduction
41 0II. Ultrastructure
412
III. Composition
41 5IV. Duplication and Separation
42 1V. Fertilization and the First Mitotic Division
427VI. Precortical Divisions
43 0VII. Cortical Divisions
432References
440
20Centrosome Maturatio nRobert E . Palazzo, Jacalyn M . Vogel, Bradley] . Schnackenberg, Dawn R . Hull,and Xingyong Wu
I. Introduction
44 9II. Centrosome Maturation
45 1III. Centrosome Structure and Microtubule Nucleation Potential
45 3IV. The Role of the Centriole
457V. The Procentrosome
45 8VI. Paternal versus Maternal Centrosomes
460VII. Summary
462References
46 3
Index
47 1Contents of Previous Volumes
485