The Development of Iron Chelators for Clinical Use, 1993, 432 pages, Raymond J.Bergeron, Gary M. Brittenham, 0849386799, 9780849386794, CRC Press, 1993

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Representing an integration of basic and clinical sciences, this book focuses on new concepts in thedesign, synthesis, and testing of iron chelators for clinical application. It provides an overview ofthe pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage,and it clearly outlines successes and shortcomings of current iron chelation therapy in preventingsuch damage. The book also describes a number of other exciting potential therapeuticapplications of iron chelators, such as in the treatment of malaria. Other topics covered includeiron coordination chemistry, recent advances in synthetic methods for accessing iron chelators,siderophore models, subcellular iron storage targets, and the possible application of biotechnologyin the production of therapeutically useful iron chelators. The book also describes new animalmodels for evaluating chelators.

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