The effect of food on triggering type II diabetes: modeling a CBD Pancreas

Mohamed Raef SmaouiApril 26th, 2012

School of Computer Science

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Outline• Role of pancreas

• Type II diabetes

• Modeling pancreas reaction (ODE)

• Modeling Beta Cells in pancreas (CBD)

• Simulation & Results

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Outline• Role of pancreas

• Type II diabetes

• Modeling pancreas reaction (ODE)

• Modeling Beta Cells in pancreas (CBD)

• Simulation & Results

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What happens when you eat?

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Role of pancreas

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Role of pancreas

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Outline• Role of pancreas

• Type II diabetes

• Modeling pancreas reaction (ODE)

• Modeling Beta Cells in pancreas (CBD)

• Simulation & Results

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Type II diabetes

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Type II diabetes (beta cells)

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Type II diabetes (amyloids)

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Glucose / Insulin in Diabetes

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Pancreas

Beta-Cells

INSULIN

GLUCOSE

Outline• Role of pancreas

• Type II diabetes

• Modeling pancreas reaction (ODE)

• Modeling Beta Cells in pancreas (CBD)

• Simulation & Results

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Pancreas reaction ODE

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Victor Bolie, Coefficients of normal blood glucose regulation, J of Applied Physiology 61

Glucose / Insulin in Diabetes

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INSULIN

GLUCOSE

Glucose / Insulin in Diabetes

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INSULIN

GLUCOSE

Beta-Cells

Pancreas

Outline• Role of pancreas

• Type II diabetes

• Modeling pancreas reaction (ODE)

• Modeling Beta Cells in pancreas (CBD)

• Simulation & Results

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Simulation (demo)

• buildSystem.py

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1700 Cal /day (400 breakfast, 900 lunch, 400 dinner)

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2500 Cal /day (200 breakfast, 1300 lunch, 1000 dinner)

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4000 Cal /day (650 breakfast, 3000 lunch, 350 dinner)

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Conclusion

• Modelled Glucose / Insulin (ODE)• 100 Beta cells cooperate to produce insulin• Each Beta Cell can– produce variable insulin and amylin (Dirichlet dist)– Infect neighbors upon death

• Diet recommendation by myHealth.py

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References• Westermark et al., Islet amyloid polypeptide, islet amyloid, and diabetes

mellitus, Physiol Rev (2009).• Marzban et al., Islet amyloid polypeptide and type 2 diabetes,

Experimental Gerontology (2003).• Lara and Vangheluwe, Atom3: a tool for multi-formalism meta-modeling,

ETAPS (2002).• Smaoui, A computational framework to create an ensemble of stable

amyloid fibrils, McGill University (2011).• Victor Bolie, Coefficients of normal blood glucose regulation, J of Applied

Physiology (1961).

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