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Christoph Lauber
Department of Psychiatry
The effectiveness of supported employment
for people with severe mental illness –
EQOLISE project
Promoting Social Inclusion and Combating Stigma
for better Mental Health and Well-Being
Lisbon, 8/9 November 2010
Employment in people with mental illness
• Employment on the free labour market
UK 10-20% (Perkins & Rinaldi, 2002)
F 5-10% (oral communication)
CH 20% (Lauber et al., 2005)
EU 10-20% (Michon et al., 2005; Marwaha et al., 2007)
• Reintegration into the free labour market: 5 – 10%
• >40% of the 2.7m people on long-term unemployment benefits have mental health
problems as their primary concern
• 2x risk of losing jobs compared with the general public
Department of Psychiatry
Proportion of employed people by health type
UK Labour Force
Survey, 2004
Difference between
physical and mental
health
Department of Psychiatry
Sheltered employment
Vocational training
Free labour market
Unemployment
x No supportx
Day hospital / vocational training
The situation
as per today
Department of Psychiatry
Supported Employment (SE): What is it about? (I)
Department of Psychiatry
• Finding „real work in the real world‟
• Immediate job search (without pre-vocational training)
The motto: First place and then train on the job
• Job coaches based in clinical teams
• Employment is an integral part of the overall care plan
SE: What is it about? (II)
Department of Psychiatry
• Job search driven by client„s preferences and choice
• Qualification on the job
• Real wages for real quality work
Sheltered employment
Vocational training
Free labour market
Unemployment
Free labour market
Unemployment
Secondary labour market Supported Employment
x No supportx
Day hospital / vocational training
The situation with supported employment
The TGV*
to work
* Train a Grande
Vitesse (Express
train)
Department of Psychiatry
SE for people with mental illness:
Individual Placement and Support (IPS)
What did we know in 2003?
• 21 studies (12 RCTs) favour IPS over “train and place”
• 20 – 60% obtain jobs in IPS
• 10 – 20% in train and place
• Accepted as the evidence based standard in USA
Department of Psychiatry
SE: The situation in the USA
• Unemployment rate 61-73%
• Wish to work 75%
• Successful reintegration SE: 61%
sheltered employment: 9%
• System - low unemployment rate
- low workplace security
- minimal health care
- low paid work places
Department of Psychiatry
SE: USA vs. Europe
• The US has tolerated levels of relative poverty that would have brought down
any European government
• European governments have tolerated levels of unemployment that would have
brought down any US government
• US „hire and fire‟ versus European employment protection and stability
• Welfare state provision: European benefits higher
Department of Psychiatry
EQOLISE: Design and Method (I)
1. Randomised control trial (RCT) in six European countries: UK (London),
Bulgaria (Sofia), Germany (Ulm), Italy (Rimini), NL (Groningen), Switzerland
(Zurich)
2. Patients with psychotic disorders or bipolar disorder and extensive
unemployment (>1y)
3. Living in community at baseline
4. Displaying major role dysfunction for >2 years
Department of Psychiatry
EQOLISE: Design and Method (II)
5. Wish to work! motivation
6. Continuous medical treatment in a community mental health centre or a local
equivalent
7. Randomisation at the patient level stratified by: centre, gender and work history
8. N=312, min. 50 in each centre
Department of Psychiatry
EQOLISE: Design and Method (overview)
Data assessment:
0 Mt. 6 Mt. 12 Mt. 18 Mt.312 clients
156 clients in the control group
156 clients in the experimental group
Department of Psychiatry
What are the most heard concerns?
• Work will worsening mental health
• Lacking support
• Low understanding of employers and staff
• Benefit review causing financial consequences
• Just getting low quality jobs
Department of Psychiatry
Department of Psychiatry
The effectiveness of supported employment for people
with severe mental illness: a randomised controlled trial
in six European countries
Tom Burns, Jocelyn Catty, Thomas Becker, Robert E. Drake,
Angelo Fioritti, Martin Knapp, Christoph Lauber, Wulf Rössler,
Toma Tomov, Jooske van Bussenbach, Sarah White, Durk Wiersma
2007; 370: 1146-1152
Effectiveness of IPS
Department of Psychiatry
IPS Voc rehab
• Worked for at least 1 day (%) 54.5 27.6*
• No days employed (mean) 130.3 30.5*
• Job tenure (d) 213.6 108.4*
* p<0.001
0
10
20
30
40
50
60
70
80
90
London Ulm Rimini Zurich Groningen Sofia
Perc
en
tag
e
Primary outcome: worked for at least 1 day
IPS
Vocationalservices
IPS: employment during the study period (Zurich data)
0 5 10 15 20 25
1
12
cli
en
ts
Months
Arbeitssuche
Beschäftigung
Predictors of employment
Department of Psychiatry
OR
Work history 2.42 (p<0.001)
Diagnosis, symptoms, social functioning, ns
QoL, needs, therapeutic relationship
Catty et al., Br J Psychiatry 2008
Predictors of job tenure
Department of Psychiatry
IPS p<0.01
QoL p=0.05
Diagnosis, symptoms, social functioning, ns
needs
Catty et al., Br J Psychiatry 2008
Does SE make you ill? (I)
Department of Psychiatry
Hospitalised (%) Time in hospital (%)
IPS 20.1 4.6
Voc rehab 31.1 8.9
p <0.05 <0.01
(Burns et al., Schizophr Bull 2009)
Does SE make you ill? (II)
Department of Psychiatry
Job 1 Job 2 Job 3
PANSS1
PANSS2
PANSS3
Hosp 1 Hosp 2 Hosp 3
IPS0
iPANSS
sPANSS
PANSS0Autoregressive latent trajectory (ALT): combining the latent trajectory
model and the autoregressive model for the examination of
longitudinal relationships between repeatedly measured variables
Does SE make you ill? (III)
Department of Psychiatry
Job1 Job2 Job3
PANSS1
PANSS2
PANSS3
Hosp1 Hosp2 Hosp3
IPS0
iPANSS
sPANSS
PANSS0
OR 0.702
OR = 2.221 OR = 2.221
OR = 2.596OR = 2.596
b = 1.717
b = 1.558
OR 1.763
OR 1.014
(Kilian et al., submitted)
What about medication? (I)
Department of Psychiatry
Influence medication vocational outcomes* NO
- Antipsychotics
- dosage NO
- atypical vs typical NO
- depot vs oral NO
- Antidepressants NO
- Benzodiazepines NO
- Mood stabilizers NO
* Working at least one day, number of days worked, time to employment (Lauber et al., submitted)
What about medication? (II)
Department of Psychiatry
Influence of vocational outcomes* on medication NO
- Antipsychotics NO
- Antidepressants NO
- Benzodiazepines YES
- Mood stabilizers NO
Change in medication dosage due to work (antipsychotics only) NO
* Working at least one day, number of days worked, time to employment (Lauber et al., submitted)
What about clients’ preferences?
Department of Psychiatry
Preferences, consistency Vocational outcomes* NO
Job satisfaction NO
Employment (±preferred job) Preferences, consistency +
Consistency of clients‟ preferences
- Previous work history -
- Service allocation (IPS, control) NO
* Working at least one day, number of days worked, time to employment (Lauber et al., submitted)
What about the costs?
Department of Psychiatry
IPS produced better outomces at lower cost to the health and social care system.
- Available cases: Total costs over 18 months IPS < CVR
Imputed cases: Total costs over 18 months no difference
- IPS with a much bigger decline of inpatient costs (-£2,700) in the first 6 months
- IPS with overall higher intervention costs when compared to CVR
- Incremental cost-effectiveness: effectiveness, costs
Overall IPS dominates
Site-specific IPS dominates (ex. Groningen)
Knapp et al., submitted
Summary
Department of Psychiatry
IPS when compared to conventional vocational rehabilitation is
• More effective
• More cost-effective
• Not making people ill
• Not related to medication
• Independent of clients‟ job preferences (incl. consistency)
• Better only in an initial phase
• Not a solution for everybody!
This paper was produced for a meeting organized by Health & Consumers DG and represents the views of its author on thesubject. These views have not been adopted or in any way approved by the Commission and should not be relied upon as a statement of the Commission's or Health & Consumers DG's views. The European Commission does not guarantee the accuracy of the dataincluded in this paper, nor does it accept responsibility for any use made thereof.