The heterogeneity model

gL

VL

gCa

VCa

C Vm

C = gL(Vm -VL)+gCa(Vm-VCa)dVdtgCa = gCa m3h

gCa (mS/cm2)

g L(m

S/c

m2 )

dhdt

hinf(Vm)-h= h

Reconstructing the phase diagram

The line connecting the two cells crosses the oscillating zone.

The combination of the average channel densities falls inside the oscillating or stable zone.

gCa (mS/cm2)

g L(m

S/c

m2 )

5 mV

100 ms

Timing of neuronal output by subthreshold oscillations

IV=I+II

V=IV-III

The timing of neuronal output is frequency dependent