THE IMMUNE SYSTEMThe Invaders The Defender

Antibodies Cytokines Complement Inflammatory mediators

COMPONENTS OF THE IMMUNE SYSTEM

Cellular components of the immune system

Soluble mediators of the immune system

Lymphocytes Phagocytes Granulocytes

Large granular lymphocyte

T-cell

B-cell Mononuclear phagocyte

Neurtrophil

Eosinophil

Basophil

Mast cell

Platelets

Others

ORIGINATION OF CELLULAR COMPONENTS

Pluripotent Stem cell

Myeloid Stem cell

Lymphoid stem cell

MonocyteNeutrophil

Macrophage

PlateletsEosinophil Basophil Mast cell

B-cellT-cell Plasma cell

Natural killer cell

THE EVOLUTION OF IMMUNITY

Immunity

Innate immunity Acquired immunity

Non-specific SpecificImmediate onset Delay onset

Humoral Immune Response

Cellular Immune Response

Antibodies production T-cell activation

INNATE IMMUNITY

1st Line Defense

2nd Line Defense

Pathogenic invasion Bacteria Viruses

Skin Ciliated cells Lysozyme Coughing

Blood clot Mast cell Cytokines

Vomitting

Leukocytes

THE INFLAMMATORY RESPONSE

Capillary widening

Increased blood flow

Increasedcapillary

permeability

Release of fluid

Leukocyteattraction

Leukocyticmigration

Systemicresponse

Leukocyticproliferation

Heat, Redness, Tenderness, Swelling, Pain

Tissue injury caused by pathogenic invasion

THE COMPLEMENT CASCADE

The Complement System

Mannose bindingAntibody binding

Opsonization Inflammation Cytolysis

Classical Alternative

ACQUIRED IMMUNITY

B-Cell Activation

Cytotoxic T-Cell Activation

Humoral Immunity

Cell-mediated Immunity

Antibodies Production

Cell lysis

Cytokines

Cytokines

ActivatedTH cell

ATTRIBUTES OF ACQUIRED IMMUNITY

Immunological SpecificityImmunological Tolerance

APC

Receptor

B-cell

Plasma cell

MemoryB-cell

MatureT-cell

MemoryT-cell

Activated T-cell

Immunological memory

THE MHC PROTEINS: CLASS I

THE MHC PROTEIN: CLASS II

RECOGNITION OF CLASS I MHC PROTEIN

RECOGNITION OF CLASS II MHC PROTEIN