The International Meeting of the Israeli Society of Oral

The International Meeting of the Israeli Society of Oral Medicine (ISOM), Nov. 6-7, 2008

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TENTATIVE SCIENTIFIC PROGRAM (Updated October 23, 2008)

Thursday, November 6, 2008 Time Session Speakers 08:00-08:45 Registration, Refreshments and Commercial Exhibition

Dr. Sharon Elad, Conference Chair Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem Dr. Itzhak Chen President, Israeli Dental Association

08:45-09:00 OPENING REMARKS

Dr. Hezi Levi Surgeon General, Ministry of Health Introduction: MASCC/ISOO Prof. Doug Peterson1, Prof. Dan Galili2

1Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; University of Connecticut Health Center, Farmington, Connecticut, USA 2Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem

09:00–09:45 SESSION 1: Chair: Dr. Sharon Elad Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem KEYNOTE:

Impact of Oral Cancer and Oral Complications in Oncology Patients Prof. Douglas E. Peterson Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; University of Connecticut Health Center, Farmington, Connecticut, USA Treatment of Head and Neck Cancer Dr. Salem Billan Department of Oncology, Rambam Medical Center, Haifa

09:45–11:00 SESSION 2: Chair: Dr. Ran Yahalom Department of Oral & Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer Dr. Mark Penn Maxillofacial Prosthetics Rehabilitation Unit, Sheba Medical Center, Tel-Hashomer

Sponsored by:

Maxillectomy – Excision and Reconstruction Prof. Dan Fliss Department of Ear Nose and Throat, Tel Aviv Sourasky Medical Center, Tel Aviv

11:00-11:30 Coffee Break, Poster Exhibition and Commercial Exhibition Alcohol Containing Mouth Rinses and Oral Cancer: Dispelling the Myth Prof. Stuart Fischman Department of Oral Diagnostic Sciences, School of Dental Medicine, Buffalo, NY, USA

11:30–12:25 SESSION 3: Chair: Prof. Alice Markitziu Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem Dr. Gabi Lavie Dental Clinic, Pardesia

Sponsored by Neopharm:

SCC of the Oral Tongue in "Young" and "Old": A Clinicopathologic Analysis Dr. Alex Dobryian1, Ran Yahalom1, Lev Bedrin2, YP Talmi2, Shlomo Taicher1, Marilena Vered3,4 1Dept. of Oral & Maxillofacial Surgery, V 2Dept. of Otorhinolaryngology Head & Neck Surgery, Tel Hashomer Medical Center 3School of Dental Medicine, Tel Aviv University 4Institute of Pathology, Tel Hashomer Medical Center


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The Role of Tumor Markers in Head and Neck Cancer – Concomitant Analysis of Salivary Tumor Markers Prof. Rafael Nagler Oral Biochemistry Laboratory, Rambam Medical Center and Rappaport Faculty of Medicine, Israel Institute of Technology-Technion, Haifa Oral Cancer in Israel 1970-2006: Subtypes, Survival and Trends by Anatomic Sites Dr. Rakefet Czerninski1, Avi Zini 2, Harold Sgan-Cohen2 1Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem 2Department of Community Dentistry, Hebrew University-Hadassah School of Dental Medicine, Jerusalem Metastasis to Oral Cavity – 673 Cases A. Hirshberg, Dr. Ana Shnaiderman-Shapiro, I. Kaplan, R.Berger Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv

12:25–13:15 SESSION 4: Chairs: Dr. Micha Peled1, Dr. Meir Rakocz2

1Department of Oral & Maxillofacial Surgery, Rambam Medical Center, Haifa 2Pediatric & Hospital Dental Division, Sheba Medical Center, Tel-Hashomer

The Incidence of Occult Metastasis Found in Elective Neck Dissection in T1/T2 N0 Oral Cancer Patients Treated In Our Department in the Last Decade Dr. Imad Abu El-Naaj1, Myrela Shveis1, Yoav Leiser1, Micha Peled1, 2 1The Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa 2The Faculty of Medicine, Technion, Haifa

13:15–14:15 Lunch, Poster Exhibition and Commercial Exhibition KEYNOTE: Treatment - Related Mucosal Injury in Cancer Patients Prof. Steve Sonis Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine; Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry Dana-Farber Cancer Institute Boston, MA USA

14:15–15:20 SESSION 5: Chair: Dr. Noam Yarom Department of Oral & Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer Prof. Meir Gorsky

Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel Aviv

State of the Art in Management of Graft Versus Host Disease Prof. Reuven Or Department of Bone Marrow Transplantation, Hadassah University Medical Center, Jerusalem


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Complementary & Integrative Medicine's Role in Oral Oncology Dr. Elad Schiff Bnai- Zion Medical Center, Haifa Department of Complementary Medicine, Law & Ethics at the International Center for Health Law & Ethics, Haifa University, Haifa Electronic Intra-Oral Device to Treat Xerostomia Dr. Andy Wolff Saliwell Inc., Harutzim Bisphosphonate-Induced Osteonecrosis of the Jaws: The Sheba Medical Center Experience Dr. Towy Sorel Lazarovici1, Ran Yahalom1, Shlomo Taicher1, Sharon Elad2, Izhar Hardan3, Noam Yarom1,4 1Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer. 2Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem 3Department of Hematology Sheba Medical Center, Tel-Hashomer. 4Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv

15:20–16:15 SESSION 6:

Chairs: Prof. Israel Kaffe

Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel Aviv

Malignant Salivary Gland Malignancies and COX-2: A Histopathological and Immunohistochemical Analysis with Implications on Histogenesis Dr. Sharon Akrish1, Micha Peled1,3, Rafi M. Nagler 1,3, Ofer Ben-Izhak 2,3 1Department of Oral and Maxillofacial Surgery: Rambam Medical Center, Haifa 2Department of Pathology, Rambam Medical Center, Haifa 3Technion-Faculty of Medicine, Haifa


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Friday, November 7, 2008 0815-0900 Gathering

The Role of Computer-Assisted Transepithelial Brush Biopsy Analysis in Preventing Oral Cancer Prof. Stephan Frist OralCDx Laboratories Inc., Suffern, NY USA

09:00–09:40 SESSION 7:

Chairs: Prof. Dan Dayan1, Dr. Rakefet Czerninski2

1Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel Aviv 2Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem

Aneuploidy in Oral Carcinogenesis Dr. Avraham Hirshberg Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel Aviv

p90/CIP2A, Implication in the Early Detection and Transformation of Head and Neck Cancer Prof. Joseph Katz Department of Oral Medicine, College of Dentistry, University of Florida, Gainesville, Florida, USA

09:40–10:20 SESSION 8:

Chair: Dr. Silvina Fridlander Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem Prof. Mark Littner Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel Aviv

The 2005 WHO Classification of Odontogenic Tumors Welcomes the New Member - The Keratocystic Odontogenic Tumor Dr. Vered Marilena Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel Aviv

10:20–11:00 EXPERTS PANEL: Moderator: Dr. Sharon Elad Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem

Clinical Dilemmas in Oral Oncology Prof. Adi Garfunkel Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem Prof. Raphael Nagler Department of Oral & Maxillofacial Surgery, Rambam Medical Center, Haifa Prof. Shlomo Taicher & Dr. Noam Yarom Department of Oral & Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer

11:00–11:45 Brunch, Poster Exhibition and Commercial Exhibition 11:45–12:25 SESSION 9:

Chair: Prof. Dan Galili Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem

KEYNOTE: Considerations in the Design and Implementation of Clinical Trials for Oral Mucositis Prof. Steve Sonis Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine; Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry Dana-Farber Cancer Institute Boston, MA USA

12:25–12:40 SESSION 10:

Chairs: Dr. Andy Wolff 1, Dr. Ilana Kaplan2

1Saliwell Inc. 2Rabin Medical Center, Petah Tiqva; and Sackler School of Medicine, Tel-Aviv University

ISOM Young Investigator Award Sponsored by:

Neopharm

KEYNOTE: Current Approaches and New Directions for Management of Oral Mucositis in Cancer Patients Prof. Doug Peterson Department of Oral Health and Diagnostic Sciences School of Dental Medicine; University of Connecticut Health Center Farmington, Connecticut, USA

12:40–13:45 SESSION 11:

Chairs: Prof. Eliezer Kaufman

Department of Oral Medicine, Hadassah & Hebrew University, Jerusalem

Prof. Mark Littner Department of Oral Pathology and Oral Medicine, Tel-Aviv University, Tel-Aviv

Medicolegal Aspects of Oral Diagnosis and Management of Oncology Patients Dr. Navot Givol Department of Oral & Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer


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LIST OF POSTERS 1 - Tunel – An Efficient Prognosis Predictor of Salivary Malignancies

Ofer Ben-Izhak1, Zvi Laster2, Shareef Araidy2, Rafael M. Nagler2,3 1Department of Pathology, Rambam Medical Center, Haifa 2Department of Oral & Maxillofacial Surgery, Poriya Hospital, Tiberias 3Department of Oral & Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa

2 - The Prognostic Role of Molecular Markers in Ameloblastoma of the Oral and Maxillofacial Region

Yoav Leiser1, Imad Abu-El-Naaj1, Ofer Ben-Izhak3, Micha Peled1,2 1The Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa 2The Faculty of Medicine, Technion, Haifa 3Department of Pathology, Rambam Medical Center, Hafia

3 - The Expression and Possible Prognostic Role of Heparanase in Invasive Squamous Cell Carcinoma

Versus Locally Aggressive Non Metastasizing Verrucous Carcinoma of the Oral and Maxillofacial Region Yoav Leiser1, Imad Abu-El-Naaj1, Ofer Ben-Izhak3, Dan Deutsch5, Philip Lazarovici6, Israel Vlodavsky4, Micha Peled1, 2 1The Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa 2The Faculty of Medicine, Technion, Haifa 3Department of Pathology, Rambam Medical Center, Haifa 4The Institute for Cancer and Vascular Research, Faculty of Medicine, Technion, Haifa 5Dental Research Laboratory, Institute of Dental Sciences, the Hebrew University Faculty of Dental Medicine, Hadassah Medical Center, Jerusalem 6Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem

4 - Multifocal Oral Cancer in Patients with Oral Chronic Graft-Versus-Host Disease

Sharon Elad1, Daood Abid El Raziq2, Rakefet Czerninski1, Nathaniel Treister3 1Department of Oral Medicine 2Department of Oral and Maxillofacial Surgery, Hebrew University – Hadassah School of Dental Medicine, Jerusalem 3Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts, USA

5 - Validation of the National Institute for Health (NIH) Scale for Oral Chronic Graft Versus Host Disease

(cGVHD) Itai Zeevi1, Michael Y Shapira2, Reuven Or2, Sharon Elad1 1Department of Oral Medicine, Hebrew University – Hadassah School of Dental Medicine 2Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Medical Center, Jerusalem

6 - Treatment Outcome of Bisphosphonate-Related Osteonecrosis of the Jaws: Intravenous vs. Oral

Administration Noam Yarom 1,2, Towy Sorel Lazarovici1, Shlomo Taicher1, Sharon Elad3, Ran Yahalom1

1Department of Oral and Maxillofacial Surgery, Sheba Medical Center, Tel-Hashomer

2Department of Oral Pathology and Oral Medicine, the Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 3Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem

7 - A Severe Gingival Infection with Stenotrophomonas Maltophilia in a Neutropenic Patient

Ana Pikovsky, Yehuda Zadik, Ron Golan, Yaron Haviv, Sharon Elad Department of Oral Medicine, Hebrew University - Hadassah School of Dental Medicine, Jerusalem

8 - Bisphosphonate-Related Osteonecrosis of the Jaws: Clinical Correlations with Computerized

Tomography Presentation Sharon Elad1, Moshe J. Gomori2, Noa Ben-Ami3, Silvina Friedlander4, Eran Regev5, Towy S. Lazarovici6, Noam Yarom5,6 1Department of Oral Medicine, the Hebrew University-Hadassah School of Dental Medicine, Jerusalem; 2Department of Clinical Radiology, Hadassah University Medical Center, Jerusalem; 3Department of Oral and Maxillofacial Surgery, the Hebrew University-Hadassah School of Dental Medicine, Jerusalem 4Department of Oral and Maxillofacial Surgery, "Sheba" Medical Center, Tel-Hashomer

5 Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 6Department of Oral and Maxillofacial Surgery, the Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv


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9 - Ki67, P53 and P63 in Oral Dysplasia: A Retrospective Study

Rakefet Czerninski¹, Maayan Granit1,Ilana Kaplan2

¹Department of Oral Medicine, the Hebrew University-Hadassah, School of Dental Medicine, Jerusalem ²Institute of Pathology, Rabin Medical Center and Sackler School of Medicine, Tel-Aviv University

10 - Chromosomal Numer ical Aberrations in Oral Lichen Planus

N. Yarom1, T. Shani2, N. Amariglio2, S. Taicher1, I. Kaplan3, M. Vered1, G. Rechavi2, L. Trakhtenbrot2, A. Hirshberg4 1Department of Oral and Maxillofacial Surgery, the Chaim Sheba Medical Center, Tel Hashomer 2Cancer Research Center, the Chaim Sheba Medical Center, Tel-Hashomer 3Institute of Pathology, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva 4Department of Oral Pathology and Oral Medicine, the Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv

11 - Lymphoepithelial Carcinoma of the Sublingual Gland – A Case Report and Review of Literature

Alex Kelner1, Imad Abu El-Naaj1, Yoav Leiser1 And Micha Peled1,2 1Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa 2Faculty of Medicine, Technion, Haifa

12 - Sialolipoma of the Salivary Gland: Two New Case Reports and Literature Review

Sharon Akrish1, Yoav Leiser1, Dror Shamir1, Micha Peled1,2 1Department of Oral and Maxillofacial Surgery: Rambam Medical Center, Haifa 2Technion-Faculty of Medicine, Haifa

13 - A Severe Gingival Infection with Stenotrophomonas Maltophilia in a Neutropenic Patient

Ana Pikovsky, Yehuda Zadik, Ron Golan, Yaron Haviv, Sharon Elad Department of Oral Medicine, Hebrew University - Hadassah School of Dental Medicine, Jerusalem

14 - Smoking and Aneuploidy in the Oral Cavity

Tali Shani1,3, Cabba Ala3, Ben Dov Issaschar4, Iris Adam 2, Ninette Amariglio1, Gideon Rechavi1, Luba Trakhtenbrot 1, Abraham Hirshberg 3 1Cancer Research Center, the Chaim Sheba Medical Center, Tel-Hashomer, Israel 2Department of Oral and Maxillofacial Surgery, the Chaim Sheba Medical Center, Tel Hashomer 4Institute of Pulmonology, Physiology and Exercise, the Chaim Sheba Medical Center, Tel-Hashomer 3Department of Oral Pathology and Oral Medicine, the Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv

15 - Targeting Mtor by Rapamycin Prevents Tumor Progression in an Oral Specific Chemical

Carcinogenesis Model Rakefet Czerninski1, Panomwat Amornphimoltham2, Vyomesh Patel2, Alfredo A. Molinolo2, J. Silvio Gutkind2 1Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem 2Oral and Pharyngeal Cancer Branch, National Institute of Craniofacial and Dental Research, National Institutes of Health, Bethesda, MD

16 - Sialadenitis Following Radioiodine Therapy - A New Diagnostic and Treatment Modality

Yaron Nazarian, Oded Nahlieli Barzilai Medical Center - Oral & Maxillofacial Surgery, Ashkelon

17 - A Survey of the of Oral Pathology Service, Tel Aviv University, Over A 20-Year Period with Particular

Reference to the Changing Trends in Oral Cancer Ana Shnaiderman-Shapiro, Amos Buchner, Marilena Vered Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv

18 - Oral Infection by Resistant Cmv in a Hodgkin Disease Patient

Yehuda Zadik1, Alexander Lvovich2, Sharon Elad1 1Department of Oral Medicine, Hebrew University – Hadassah School of Dental Medicine, Jerusalem 2Department of Bone Marrow Transplantation, Hadassah University Medical Center, Jerusalem


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19 - Immediate and Delayed Effect of Chemotherapy on Salivary Flow in Cancer Patients

Tzippy Davidowitz1, Salomon M. Stemmer2,4, Ilana Kaplan3,4. 1Faculty of Dental Medicine, Hebrew University and Hadassah 2Institute of Oncology, Davidoff Center, Rabin Medical Center 3Institute of Pathology, Rabin Medical Center, Beilinson CAMPUS 4Sackler School of Medicine, Tel-Aviv University

20 - Stromal Myofibroblasts in Tongue Squamous Cell Carcinoma: Pattern of Distribution and Possible Origin

from Carcinoma Cells by Epithelial-Myofibroblast Transformation Irit Allon, Marilena Vered, Dan Dayan Department of Oral Pathology and Oral Medicine, School of Dental Medicine, Tel Aviv University, Tel Aviv

21 - Anaploidic Cell Dtetction in Premalignant Oral Lesions Using Combined Morphological and Fish

Analysis- A New Method for Early Detection of Suspicious Oral Leukoplakic Lesions Iris Adam1, Noam Yarom1, Ninette Amariglio2, Ran Yahalom1, Rachel Stanchescu2, Issahar Ben-Dov3, Shlomo Taicher1, Gideon Rechavi2 , Luba Trakhtenbrot2, Abraham Hirshberg4 1Department of Oral and Maxillofacial Surgery, the Chaim Sheba Medical Center, Tel-Hashomer 2Cancer Research Center, the Chaim Sheba Medical Center, Tel-Hashomer 3Institute of Pulmonology, Physiology and Exercise, the Chaim Sheba Medical Center, Tel-Hashomer 4Department of Oral Pathology and Oral Medicine, the Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University, Tel Aviv

22 - Nasal Nk/T Cell Lymphoma: A Case Report

G. Almoznino1, A. Dobryian2,3, M. Vered3 1Israel Defense Forces, Ramat-Gan, Israel 2Tel Hashomer Medical Center, Israel 3Tel Aviv University, Tel-Aviv, Israel

23 - The Role of Dental Hygienists in Improving Hospital-Based Treatment in Oncology Patients

Yael Carlin 1,2, Ruth Radiano3, Maya Aaroni4 1Israeli Dental Hygiene Association 2Dental Clinics for People with Special Needs, Ministry of Social Affairs, Ministry of Education 3Department of Bone Marrow Transplantation, Hadassah University Medical Center 4Department of Oral Medicine, Hebrew University – Hadassah School of Dental Medicine, Jerusalem

24 - Orange Oral Mucosal Lesions – A Rare Clinical Manifestation of Amyloidosis

Na'ama Keshet, Neta Goldshmidt, Sharon Elad Department of Oral Medicine, Hebrew University - Hadassah School of Dental Medicine, Jerusalem Department of Hematology, Hadassah University Medical Center, Jerusalem

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The International Meeting of the Israeli Society of Oral