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The Macronutrients - Lipids
Chapter 1
Lipids
Lipid is a general term for a heterogeneous group of compounds.• Oils, fats, waxes, and related compounds
• Simple lipids
• Compound lipids
• Derived lipids
Lipids
Functions Provide energy
Protect vital organs
Provide insulation from the cold
Transport the fat-soluble vitamins A, D, E, and K
Lipids
Simple lipids
• Neutral fats – consist primarily of triacylglycerols • Triglycerides
• Major storage form of fat in adipose cells
Triglycerides
Triglycerides• C,H,O
• Composed of 3 fatty acids (FA)
• Glycerol molecule
• TG vary in the type of FA and their bonding pattern• FA vary in the number and arrangement of
double bonds
• Usually even number C
Acetic Acid
Triglyceride
Fatty Acids
Saturated fatty acids Single covalent bonds between carbon
atomsCovalent bonds share electrons
All of the remaining bonds attach to hydrogen.
Fatty Acids
Unsaturated fatty acids One or more double bonds along the main
carbon chain.
• Monounsaturated fatty acid - one double bond.
• Polyunsaturated fatty acid - two or more double bonds.
Fatty Acids
Stearic acid, an 18-carbon saturated fatty acid
Fatty Acids
Oleic acid, an 18-carbon monounsaturated fatty acid
Lipids
Stability • Oxygen exposure causes spoilage-rancid
• PUFA’s spoil more easily
• Increase saturation• Hydrogenation
• Prolongs shelf life – prevents oxidation
• Alters texture – liquids → solids
Hydrogenation
Hydrogenation
Trans-Fatty Acids• Changed from cis to trans configuration and
act like saturated fats in the body• Partial hydrogenation
• Higher melting point
Trans-Fatty Acids
Dietary Lipids
Typical daily intake (< 30% total kcals)• Should consist of:
• 65% animal lipids
• 35% vegetable lipids
• <10% saturated
• Little or no trans fat
Essential Fatty Acids
Double bonds• Omega number
• Position of first double bond• Omega-3 FA – 3rd position
• Linolenic acid
• Omega-6 FA – 6th position
• Linoleic acid
Body can only make double bonds after the 9th carbon from the omega end
Linolenic Acid – omega-3
Fatty Acids-omega-6
Linoleic acid, an 18-carbon polyunsaturated fatty acid
Essential Fatty Acids
Functions• Immune function,
• Vision
• Cell membrane, and
• Production of hormone-like compounds
Essential Fatty Acids
Omega-3 Omega 6
Alpha-linolenic acid Linolenic acid
DHA EPA Arachidonic Acid (docosahexanoic (eicosapentaenoic
acid) acid)
Essential Fatty Acids
DHA, EPA• Decrease blood clotting
• Care must be taking when supplementing DHA, EPA when on anticoagulant medication
• Or when having surgery
• Reduce heart attacks• Fish oils have an anti-arrhythmic effect on myocardial
tissue.
• Decrease inflammation, pain
Compound Lipids
Phospholipids • Built on a glycerol backbone
• One or more FA
• Phosphorus group
• Nitrogenous base
• Found in body, cell structures
• Synthesized by the body as needed• liver
• Not needed in diet, not essential
Compound Lipids
Phospholipids• Contain polar head groups
• Hydrophilic head (protein)
• Hydrophobic tail (two FA chains)
• Allows for movement of fat soluble substances• Vitamins
• Hormones
Phospholipids
Compound Lipids
Phospholipids• Lecithin - 5% of lipids in diet
• Eggs
• Liver
• Soybeans
• Wheat germ
• Peanuts
Compound Lipids
Glycolipids: Fatty acid bound with carbohydrate and nitrogen
Essential part of cell membranes
Glycolipids
Compound Lipids
Lipoproteins: Proteins joined with triacylglycerols or
phospholipids
Primary method of lipid transport
High, Low-Density Lipoprotein Cholesterol
5 types of lipoproteins exist• Based on gravitational density
• Chylomicrons, VLDL, IDL, LDL and HDL
Chylomicrons – fat droplets • Long chain triacylglycerols
• Phospholipids
• Free fatty acids
• A,D,E,K
Chylomicron
Compound Lipids
Lipoproteins • Very low density lipoprotein (VLDL)
• Formed in liver
• 95% fat (60% triacylglycerol)
• Transports triacylglycerols to muscle, adipose
• Oxidation of VLDL and uptake of triglycerides into cell (lipoprotein lipase)
Compound Lipids
Lipoproteins • Low density lipoprotein (LDL)
• Contain less lipid than VLDL
• Carry most of the cholesterol (60-80%)
• Great attraction to cells of arterial walls
Cholesterol
Lipoproteins• High density lipoproteins
• Scavenger
• Reverse transport of cholesterol
• Delivers cholesterol to liver
• Bile
• Excretion through intestinal tract
Cholesterol
Exogenous • Dietary cholesterol (300 mg)
Endogenous • Cellular synthesis (70% in liver)
• 0.5 to 2.0 g/day
• Sufficient for body’s needs