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P reventive and clinical medicine (HERALD OF THE MECHNIKOV SAINT-PETERSBURG STATE MEDICAL ACADEMY)

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ISSN 2074-9120Preventive and clinical medicine (Herald of the Mechnikov Saint-Petersburg state medical academy).2010 № 1 (34), 241 pp.

Editor-in-chief Academician of RAMS, Honoured scientist of RF, M.D., Professor A.V.Shabrov

EDITORIAL BOARDAcademician of RAMS, Honoured Scientist of RF, M.D., Professor V.G.ARTAMONOVA (Saint-Petersburg), M.D., Professor A.M.BOLSHAKOV (Moscow), A.A.BORISOV (Saint-Petersburg), Honoured Scientist of RF, M.D., Professor V.A.DOTSENKO (Saint-Petersburg), M.D., Professor L.P.ZUEVA (Saint-Petersburg), M.D., Professor S.I.IVANOV (Moscow), M.D., Professor A.V.ISTOMIN (Moscow), M.D., Professor V.R.KUCHMA (Moscow), M.D., Professor B.V.LIMIN (Vologda), Honoured Scientist of RF, M.D., Professor V.S.LUCHKEVICH (Saint-Petersburg), Honoured Scientist of RF, M.D., Professor V.G.MAIMULOV (vice-editor-in-chief, Saint-Petersburg), Academician of RAMS, Honoured Scientist of RF, M.D., Professor G.G.ONISCHENKO (Moscow), Academician of RAMS, Honoured Scientist of RF, M.D., Professor Yu.Р.PIVOVAROV (Moscow), Academician of RAMS, Honoured Scientist of RF, M.D., Professor S.N.PUZIN (Moscow), Academician of RAMS, Honoured Scientist of RF, M.D., Professor, Yu.A. RAKHMANIN (Moscow), M.D., Professor P.G.ROMASHOV (Saint-Petersburg), Academician of RAMS, Honoured Scientist of RF, M.D., Professor P.I.SIDOROV (Arkhangelsk), Academician of RAMS, Honoured Scientist of RF, M.D., Professor G.A.SOFRONOV (Saint-Petersburg), Academician of RAMS, Honoured Scientist of RF, M.D., Professor V.I.STARODUBOV (Moscow), M.D., Professor E.I.TKACHENKO (Saint-Petersburg), Academician of RAMS, Honoured Scientist of RF, Professor V.A.TUTELIYAN (Moscow), Honoured Scientist of RF, M.D., Professor V.P.CHASCHIN (Saint-Petersburg), M.D., Professor T.S.CHERNYAKINA (executive secretary, Saint-Petersburg)

EDITORIAL COUNCILCorresponding member of RAMS, M.D., Professor N.M.ANICHKOV (Saint-Petersburg), Candidate of Medicine A.I.VERESCHAGIN (Moscow), M.D., Professor L.I.GLUSHKOVA (Syktyvkar), M.D., Professor S.A.GORBANEV (Saint-Petersburg), M.D., Professor V.A.DADALI (Saint-Petersburg), M.D., Professor G.I.DIYACHUK (Saint-Petersburg), Corresponding member of RAMS, M.D., Professor N.V.Zaitseva (Perm), M.D., Professor A.L.ZELDIN (Saint-Petersburg), Doctor of Biology, Professor A.L.KOVALENKO (Saint-Petersburg), Corresponding member of RAMS, Professor B.A.KURLYANDSKY (Moscow), M.D., Professor S.A.LINNIK (Saint-Petersburg), M.D., Professor A.V.MELTSER (Saint-Petersburg), M.D., Professor S.V.NAGORNY (Saint-Petersburg), M.D., Professor V.I.NIKOLAEV (Saint-Petersburg), M.D., Professor V.M.PETRENKO (Saint-Petersburg), M.D., Professor L.G.PODUNOVA (Moscow), Honoured Scientist of RF, M.D., Professor I.V.POLYAKOV (Saint-Petersburg), Candidate of Medicine I.A.RAKITIN (Saint-Petersburg), M.D., Professor V.G.RADCHENKO (Saint-Petersburg), M.D., Professor A.V.Skalny (Moskow), M.D., Professor E.G.TOPUZOV (Saint-Petersburg), M.D., Professor S.A.KHOTIMCHENKO (Moscow), M.D., Professor A.G. SHIMAN (Saint-Petersburg), Corresponding Member of RAMS, M.D., Professor A.P.SCHERBO (Saint-Petersburg), M.D., Professor I.Sh.YAKUBOVA (Saint-Petersburg)

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Subscription index: 42363-полугод, 42364-год

SAINT-PETERSBURG – 2010

CONTENTSPUBLIC HEALTH AND PUBLIC HEALTH SERVICES

Orel V.I., Tsiteladze A.A. Problems of physical examination of teenagers entering military educational institutions of the general secondary education

Sayed Kamruzzaman, Krasnenkov V. L., Vinogradov A.F. Analysis of infantile death

rate and factors influencing its decrease at realization of target programs in the Tver region

Petrova N.N. Characteristics of pathological ear, nose and throat diseases of the Saint-

Petersburg industrial enterprise workers

Eliovich I.G., Gorbanev S.A., Nekhoroshev А.С. On regional information databases of

social-hygienic monitoring improvement

Scherbuk A.Yu., Bashkov L.L., Donskov V.V. Experience of regenerative treatment

organization in a megacity in patients surviving hi-tech operations (St.-Petersburg as an

example)

Morozko P. N. Assessment of health and the academic progress of sports high school

students

SURROUNDING AND WORKING ENVIRONMENT

Israilova G.M, Eshmuradova S.T., Turaev I.E. Hygienic evaluation of risk factors of

contamination of dairy and meat products manufactured under water shortage conditions

Khamrakulova M.A. Carbohydrate-energy metabolism disorders in the liver

under the influence of decys pesticide and their correction by introduction of

biologically active substances

Chernushevich N.I. Upper extremities functional state in persons working in trades

with various kinds of physical activity

Figurovsky A.P., Mozzhukhina N.N., Alikbaeva L.A., Khomulo D.P., Yermolaev-

Makovsky M. A. Hygienic characteristic of working conditions at manufacturing chipboard

2

NEW TECHNOLOGIES, METHODS OF DIAGNOSTICS, TREATMENT,

PREVENTION

Nikolaev V.I., Denisenko M.D. Special characteristics of emotional tension and

hemodynamic change in man during psychoemotional stress

Minko B.A., Prokhorov D.G., Semeonova A.A., Shevtsov I.V. Ultrasonic examination of

patients with renal cancer at small-invasive surgical interventions

Kasumov V.R. Method of subpial transections in a system of surgical treatment

of multifocal epilepsy

CLINICAL AND EXPERIMENTAL STUDIES

Reznikova T.N., Semivolos V.I., Ilves A.G., Seliverstova N.A. Characteristics of

intrinsic pattern of illness at demyelination foci localization in the brain of patients

with multiple sclerosis

Zborovsky A.B., Zavodovsky B.V., Nikitina N.V., Yashina Yu.V., Budkova E.V.,

Doronina I.V., Pavlova A.B., Zborovskaya I.A. Clinical-pathogenetic value of

metabolic syndrome markers determination in patients with osteoarthritis

Komyakov B. K., Akimov A.N., Tagirov N.S., Lazarenko I.B., Gadzhiev N.K.

Combined coral calculi treatment

Kosinets V.A. Efficacy of metabolic drug "Cytoflavin" use in experimental

widespread purulent peritonitis

Sayganov S.A., Khurtsilava O.G. Acute cardiac insufficiency treatment in

myocardium infarction of the right ventricle

Shuster P.I., Tselebrovskaya O.N., Sagidullin F.A. Hypogonadism androgen

therapy efficacy and safety in patients with hyperuricemy and radically eliminated

urolithiasis

Ishinova V.A. Dynamics of tactile sensitivity in patients with psychogenic pain

in the course of mental relaxation

Galeev Sh.I., Topuzov M. E., Rubtsov M.A. Prognosis of severe acute

pancreatitis: whether consensus “Atlanta 1992” criteria enough?

3

Teplov A.Yu., Grishin S.N., Farkhutdinov A.M. Possible mechanisms of

contractile function change in isolated murine striated muscles at allergic body

change

Ermolov S.Yu., Ermolova T.V., Dobkes A.L. Role of hemodynamic factors in

evaluation of plasmaphoresis efficacy in patients with chronic liver diseases

Grinevich V.B., Lapteva E.N., Egorov D.V., Kravchuk Y.A. Estimation of the

index of body´s mass by the method of two-frequency bioelectrical impedance

analisis at the patients with discompensative cirrhosis of the liver

Chuprov I.N. The updated complex description of the skin basal cell carcinoma

EPIDEMIOLOGY, MICROBIOLOGY, INFECTIOUS AND PARASITIC

DISEASES

Akhmedova M.D., Imamova I.A. Early risk prognosis of acute renal insufficiency

development in acute enteric infections in children

Gulyamov N.G., Dalimov T.K., Mirzajanova D.B. Adrenal gland cortex

functional insufficiency in typhoid fever infection: hormonal and immunological

aspects of pathogenicity

Shoumarov S.B., Gulyamov N.G., Smagin A.A. Causes and ways of

seronegativity formation overcoming in vaccinal prevention of typhoid fever

Shvedova N.M., Mikhailova E.V., Khmilevskaya S.A. Epstein-Barr virus

mononucleosis in children. Pharmacoeconomical substantiation of immunotropic

therapy

Khalikova S.A., Daminova M.N. Amino acid spectrum and nitrogen oxide state

in blood serum of children with chronic virus hepatitis C

Khayitov R.Kh., Akhmedova H.Yu. On causes and possibility of frequency rate

decrease of human HBV, HCV and HIV infection through donor blood

Aleksandrova E.A., Kazimirova N.E., Lepilin A.V., Shuldyakov A.A. Clinical-

pathogenetic aspects of periodontitis development in patients with pulmonary

tuberculosis

4

Zarubaev V.V., Kovalenko A.L., Sologub T.V., Romantsov M. G, Petrov A.Yu.

Comparative efficacy of antiviral drugs in experimental influenza infection caused by

viruses А/Swine (Н1N1), Puerto (Н1N1), Мallard|PennsyLvania (H5 N2)

SCIENTIFIC REVIEWS

Romantsov M.G, Isakov V.A., Rybalkin S.B., Krasnov V.V., Kovalenko A.L.

Modern approaches to the treatment of herpetic infection (clinical review)

Romantsov M.G., Goryacheva L.G., Kovalenko A.L. Cycloferon for treatment and

prevention of children diseases (clinical review)

PERSONNEL TRAININGGaykovaya L.B., Kukharchik G.A., Burbello A.T., Vavilova T.V. Laboratory studies in

efficacy and safety evaluation of medicinal therapy of ischemic heart disease

Romantsov M.G., Grebenyuk T.B., Sologub T.V., Danilenkova G.G. Principles

of constructive pedagogics in educational process of higher medical schools

PUBLIC HEALTH AND PUBLIC HEALTH SERVICES

1320 Орел© V.I.Oryol, A.A.Tsiteladze, 2010

UDC 613.956:616-071.2:378

Orel V.I., Tsiteladze A.A. Problems of physical examination of teenagers

entering military educational institutions of the general secondary education //

Preventive and clinical medicine. – 2010. - № 1 (34). – Р.7-11.

¹State educational institution for high professional education «Saint-Petersburg

State Pediatric Medical Academy by Federal agency for health services and social

development»; 194100, Saint-Petersburg, Litovskaya str., 2; tel./fax: (8-812) 554-05-

83; e-mail: [email protected].

²State general secondary education school «Saint-Petersburg Military Suvorov

School»; 194011, Saint-Petersburg, Sadovaya str., 26; tel./fax: 310-18-00, e-mail:

spb-svu.nm.ru.

5


S u m m a r y : The study conducted the analysis of the medical examination

of adolescents to enroll in military schools, a comprehensive assessment of their

health status. In reforming the military education system interagency integration is

necessary in carrying out the basic stages of a medical examination of young people entering

the military school in child health clinics of the Ministry of Health.

K e y w o r d s : military school of general secondary education (college);

assessment of adolescent health status; medical examination; interdepartmental

integration.

R e f e r e n c e s

1. Баранов А.А. Профилактические основы развития приоритетного

национального проекта в сфере здравоохранения в интересах детей. / Баранов

А.А., Кучма В.Р. // Здравоохранение Российской Федерации.– 2008. – №1. – С.

10-11.

2. Рапопорт И.К. Состояние здоровья школьников и проблемы выбора

профессии. / Рапопорт И.К. // Гигиена и санитария. – 2009. – №2. – С. 36-38

3. Varni JW, et al. The Peds QL: Measurement Model for the Pediatric

Quality of Life Inventory. Medical Care, 1999; 37(2):126-139

4. Куликов А.А. Оптимизация учебно-воспитательного процесса на основе

мониторинга здоровья школьников. / Куликов А.А., Лебедев СБ., Шевченко

В.Н. // Регион: Политика. Экономика. Социология. – 2000. – №4. С. 132-135.

5. Пажеский Его Императорского Величества корпус за сто лет: в 2 т. /

авт.-сост. Д.М. Левшин. – СПб.; «Т-во Художественной печати», 1902. – с Т.1 –

С. 204-216.

6. Постановление Правительства РФ от 25 февраля 2003 г. № 123 «Об

утверждении Положения о военно-врачебной экспертизе». / Собрание

законодательства РФ. – 2003. – №10. ст. 902.

I n f o r m a t i o n a b o u t t h e a u t h o r s :

Oryol V.I. Doctor of Medicine, Professor, Honoured Scientist of FR, head of

State educational institution for high professional education «Saint-Petersburg State

6

http://elibrary.ru/keyword_items.asp?keywordid=4256497

Pediatric Medical Academy by Federal agency for health services and social

development»; 194100, Saint-Petersburg, Litovskaya str. 2; work tel. (812) 554-05-

83, mobile phone 8-921-949-41-47; e-mail: [email protected].

Tsiteladze A.A. Chief Physician of Saint-Petersburg Military Suvorov School;

work tel. (812) 310-18-00, mobile phone 8-921-791-20-66; e-mail: [email protected].

Accepted 14.10.2009 г.

1242 Сайед

UDC 614.1: 312.2: 616-053.3 (471.331)

© К. Sayed, A.G. Ivanov, 2010

The Analysis of Infant Mortality and Factors Lowering its Rate

while Implementing Strategic Programs in Tver Region

K. Sayed, A.G. Ivanov

State Educational Institution of the Higher Professional Education

“Tver State Medical Academy of the Federal Agency for Public Health and

Social Development” Tver, Russia

Sayed K., Ivanov A.G. Analysis of infantile death rate and factors influencing //


State Educational Institution of the Higher Professional Education «Tver State

Medical Academy of the Federal Agency for Public Health and Social

Development». Russia, 170100, Tver, Sovetskay str., 4. Tel. 8 (4822) 32-17-79, fax:

8 (4822) 34-43-09. E-mail: [email protected]

S u m m a r y : The research represents the analysis of infant mortality and

factors determining its rate in Tver Region for the period of 1996-2007. It reveals a

positive dynamics in the indexes of infant mortality for the last 11 years which is to

large extent can be attributed to the implementation of the «Complex Program on

Women and Child Care and Child Mortality Reduction» in Tver Region, carried out

in 1989-2010. It also proves the effectiveness of developing and launching strategic

7



programs on fighting both the rate and the definite causes of death among the

population.

K е y w o r d s : infant mortality; manageable, partially manageable and

unmanageable factors; strategic regional programs.

Infant mortality belongs to the leading index of not only the effectiveness of

the State Health Service but the national well-being on the whole. For several

decades Tver Region has been among the regions with the highest infant mortality

rates both in The Central Federal District and in Russian Federation on the whole.

T h e a i m o f r e s e a r c h was to substantiate the necessity of

developing and implementing strategic programs to lower the rate of mortality among

the population especially occurring due to definite causes.

M a t e r i a l a n d M e t h o d s o f R e s e a r c h : The research

represents the analysis of statistic data provided by the Local Committee of Federal

Statistic Data Service of Tver Region on infant mortality, perinatal mortality

including early neonatal one and mortinatality.

Multi-factor analysis applied determined quantitatively the importance and

share of different factors influencing the rate of infant mortality.

R e s u l t s o f t h e r e s e a r c h a n d t h e i r d i s c u s s i o n .

The rates of infant mortality in Tver Region in 1997-2007 fluctuated between 19.3‰

in 1998 and 9.8‰ in 2007. Since 1999 the positive dynamics of this index might be

observed – there has been a gradual decrease in infant mortality. On the whole the

index fell down by 46.2% (from 18.2‰ in 1996 to 9.8‰ in 2007). But at the same

time it continued exceeding the average rates of child mortality in Russia. By 2007

this difference has amounted 4.3% (9.4‰ throughout Russia and 25.6% throughout

the Central Federal District (7.8‰).

Similar trend could be observed in urban areas of the Region since 1999 but in

the rural area this process started a bit later – in 2002. The comparison of mortality

rates among urban and rural infants aged less than 1 year old displayed the exceeding

of deaths the latter above the former (except in the years of 1998, 2000 and 2006

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when the mortality among rural children was lower than among the urban ones.) At

the same time infant mortality in urban settlements fluctuated between 8.3‰ in 2007

and 19.9‰ in 1998, as for the rural ones the figures were 10.2‰ in 2006 and 24.1‰

in 1996. Thus positive dynamics in the rates of infant mortality could be equally

observed both in urban and in rural areas. The indexes of 1996 dropped (by 47.8%

and 42.7% correspondingly) and the most rapid changes could be observed in rural

settlements since 1996 to 2006.

In the urban districts of Tver Region the rates of infant mortality in 2007

remained within the boundaries of 5.0‰ and 16.2‰. In comparison to 1996 the

indexes decreased by 8.5% that is they became 3.6 times lower. Among the

municipal districts the range of infant mortality indexes varied considerably between

2.8‰ and 43‰. At the same time the changes in indexes for the studied period

proved diverse in different districts of the region: the increase in infant mortality was

reported in 12 districts with the decrease in 14 ones; it remained practically the same

in 4 districts and in 6 ones the cases of infant mortality were not registered at all.

The biggest drop in the mortality rate of infants aged less than 1 year old was

registered among girls (for them it became 2.1 times lower (1.5 lower for the boys))

in comparison to 1996. Thus the share of male infants in the structure of those who

died in early child age has increased. So if in 1996 this share slightly exceeded the

half of the total number of children who died under 1 year old (54.6%) in 2007 it

amounted 62.1%.

For the studied period the index of perinatal mortality in Tver Region exceeded

the average rates throughout the country (with the exception of 2000) and in 2007 the

difference made up 15.4% (10.4‰ against 8.8‰). In 2007 Tver Regin was placed the

forth among the regions of the Central Federal District in perinatal mortality

following Ryazanskaya (12.8‰), Kostromskaya (11.2‰) and Kaluzskaya (10.6‰)

Region, exceeding by 1.3‰ the average rate of the Central Federal District.

The coefficient of perinatal mortality in Tver Region was within the limits of

10.4‰ and 19.3‰ (in 2007 and 1998 correspondingly). For 11 years it has fallen by

42.8%. The dynamics of early neonatal mortality and mortinatality, determining the

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rate of perinatal mortality has remained unstable for the studied period but there has

been some progress in it. By 2007 the rate of mortinatality became 3 times smaller

and the index of early neonatal mortality dropped by 15.3%.

The causes of death among children under 1 year old proved to be different in

urban and rural areas. In the former ones perinatal death has been found out to be

responsible for 53% of deaths among newborns, in the latter ones this is the cause of

33% of deaths. The second major cause of urban newborn deaths (24% of deaths) is

congenital anomalies (22% for the rural newborns). At present the diseases of

respiratory system are considered to be a leading cause of newborn deaths in the rural

area (25%, while for the urban area it is 13%).

For the last 11 years the coefficient of infant mortality that could happen due to

definite causes has decreased; namely, the number of deaths due to the congenital

anomalies became 2.4 times smaller, mortality due to some causes of perinatal death

decreased by 31%, due to accidents, poisoning and traumas – by 40%, due to the

diseases of respiratory tract – by 38%.

The research has revealed the social character of factors contributing to the

presence of a considerable level of infant mortality in cities as well as in the rural

area. It was found out that these factors are eliminable and can be eliminated by the

collaboration of medical workers and social organizations involved. It is known that a

number of these factors fully depends on the level of health service provided for

children aged less than 1 year old, pregnant women and women in labour. The

problem of medical services available for women in labour is especially critical for

the rural settlements of the region.

The integrated evaluation of medical and social factors determining the

frequency of deaths among infants under 1 year old has revealed the following factors

being the most considerable: bad habits of a father, financial well-being of a family,

mother’s social status, mother’s marital status, parents’ heredity, living conditions,

mother’s bad habits and frequency of prenatal nursing.

In the rural areas 8 leading factors of medico-social character determining the

rate of infant mortality are as follows: father’s bad habits, mother’s social status, full-

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term of a newborn by the time of labour, financial well-being of a family, father’s

educational background, complications in labor, frequency of prenatal nursing and

mother’s marital status.

Most of these factors are of social character and refer to the category of

eliminable ones.

There has also been studied the degree of influence of social, biological and

medical factors on the infant mortality rate in the region on the whole, in the district

centers and in the rural settlements of the region.

As an instrument for measuring the influence of factors on the result a multy-

factor analysis has been applied. It provided quantitative estimates of the influence of

different factors on the result that is on the rate of infant mortality.

On the whole 27 of the manageable factors determining the mortality rate of

infants under 1 year old have been studied. They have been grouped into 3 main

types: manageable, partially manageable and unmanageable ones. Moreover within

each group factors of medical and not medical character have been distinguished.

These groups of factors are rather conventional and still they help to determine those

ones which are possible to manage in order to bring down the rate of infant mortality

and those of them which depend mostly on the quality of medical service. Obviously,

manageable factors determined are much of a practical value.

The estimates have revealed that irrespective of the type of settlement these are

manageable factors that play the major role in building the rate of infant mortality,

with factors of medical character (that is depending on the level of health service)

predominating. Among manageable factors of medical character the biggest ratio

belongs to the complications in labour (7.1% in the rural area and 12.4% in the

regional centre) as well as full-term of a newborn at birth (more than 5%).

Manageable factors of not medical character also play an important role in

building the rate of infant mortality. With their ratio of 22.2% in towns and up to

32.4% in the rural settlements of the region they are being more critical for the rate of

infant mortality in the rural area. It must be pointed out that infant mortality depends

on the way of life of parents-to-be especially that of a mother (it is responsible for

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14.7% of deaths among infants in Tver and for 29.0% of deaths in the rural

settlements).

Thus cultivating a healthy way of life among parents (fighting with smoking,

for instance) is at present primary and the most reasonable way to lower the rate of

infant mortality in towns and especially in the rural settlements. Certainly that is the

task that must be accomplished not only by medical workers but by every member of

the society.

Another priority in fighting infant mortality is the prevention of prematurity

and complications in labor, as well as carrying out definite tasks on normal physical

development of infants aged under 1 year old. The coordinating role in fulfilling

these tasks undoubtedly belongs to medical workers.

It must be pointed out that such factors as parents’ social status, their

educational background, family income and living conditions determine the rate of

infant mortality in towns as well as in the rural settlements but to very little extent.

The multifactor dispersion analysis applied allowed to determine quantitatively

the share of different factors in building the rate of infant mortality. Irrespective of

the type of settlement manageable factors proved to have the biggest ration (more

than 55%) with the factors of medical character predominating, especially in towns.

As for the rural settlements the rate of infant mortality there has been found out to be

to large extent determined by the manageable factors of not medical character,

connected with parents’ way of life and living conditions.

All the above mentioned things considered further steps towards lowering the

rate of infant mortality in Tver Region are found to depend on the implementation of

such medical and social tasks as:

the improvement of medico genetic aid provided for the population and

further development of prenatal diagnostics.

preventive measures aimed at cultivating healthy way of life among

parents, delivery and bringing up healthy children.

stricter monitoring of labour protection in respect of women.

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improving the quality of legal aid provided for families, mothers and

children.

introduction of the latest forms of data supply, record keeping and

monitoring of the effectiveness of Mother and Child Care measures.

At the same time positive dynamics of the infant mortality indexes that has

been reported for the last 11 years in the region is to large extent due to the

implementation of the “Complex Program on Women and Child Care and Child

Mortality Reduction” in Tver Region carried out in 1989-2010.

Among the key points reflected in 16 chapters of The Program the most

important are:

the improvement of prophylactic work among the youth aimed at

preserving the health of spouses-to-be.

the performance of definite tasks on improving the health of females at

different stages of their maturity and preparing them for becoming mothers.

the improvement of forms and methods of prophylactic medical

examination of pregnant women and those of fertilization age.

the improvement of quality of medical aid provided for women and

newborns in labor (optimal obstetrics)

the improvement of prophylactic and curative measures among children

(The Program “A Healthy Child”).

strengthening the financial and technical base of obstetric services and

childhood protection

improving the quality of legal and social aid provided for families,

mothers and children etc.

The main part of The Program defines the importance of improving personal

health at such stages as: improving the health of parents’-to-be (I); conception (II);

pregnancy period (III); labour (IV); postnatal period (V). Considering close

connection of the I and V stages one should speak about the closed constantly

evolving cycle passing though generations.

13

C o n c l u s i o n . Thus the main features of the above mentioned program

are its being: long-term, complex, permanent and scientific.

Being long term enables it to determine to larger extent the character and

indexes of obstetrics service.

Being complex means its phase structure and multi sided approach to bringing

up healthy children (starting with health of parents’-to-be and finishing with child

health in postnatal period following the chain: a female child – a young woman – a

woman – a pregnant woman – labour – a newborn).

Being permanent means constant development of The Program, its

improvement with respect to the changing conditions, infrastructure, financial base,

staff efficiency and financing, that will enable timely determination of priorities and

measures needed, that is this Program represents a complex integrated system, all the

levels of which are in the dynamic balance.

The implementation of this Program proves the necessity of development and

launching strategic regional programs aimed at lowering mortality rate among the

population, especially from definite causes.


Sayed Kamruzzaman – PhD in Medicine, assistant-professor of the Department

of Public Health and Public Health Services of Tver State Medical Academy, work

tel.: 8 (4822) 34-66-4, 32-07-60. E-mail: [email protected]

Ivanov Alexander Gennadievich – Doctor of Medical Sciences, Professor of

the Department of Public Health and Public Health Services of Tver State Medical

Academy, work tel.: 8 (4822) 34-57-14, 32-07-60.


1309 ПетроваUDC 616.21:613.6(470.23)

© N.N. Petrova, 2010

14

http://www.thefreedictionary.com/young+woman

Petrova N.N. Characteristics of pathological ear, nose and throat diseases of the

industrial enterprise workers // Preventive and clinical medicine. – 2010. - № 1 (34).

– Р. 14-17.

Saint-Petersburg state medical academy named after I.I. Mechnicov, Saint-

Petersburg, Russia, 195067, Saint-Petersburg, Piskariovskiy pr. 47, Tel.: 8(812)545-

13-39, fax: 8(812)545-13-39. E-mail: [email protected]

S u m m a r y : In the article are published results of occupational morbidity

contrastive analysis from the angle of the workers of water-supply. The received

results testify, that one third from all HNT illnesses are fit on ear diseases. Prevalence

of ear diseases with hearing loss is higher with influence of production loss.

K e y w o r d s : prevalence of HNT diseases; occupational morbidity;

occupational hearing loss.

R e f e r e n c e s

1. Государственный доклад о состоянии здоровья населения Российской

Федерации в 2001 г. // Здравоохранение Российской Федерации – 2003. – № 4. –

С. 3–17.

2. Илькаева Е.Н. Современное состояние проблемы профессионального

нарушения слуха в Российской Федерации / Е.Н. Илькаева // Медицина труда и

промышленная экология. – 2008. - № 6. – С. 180-182.

3. Илькаева Е.Н. Медико-социальные аспекты потери слуха в

трудоспособном возрасте / Е.Н. Илькаева // Медицина труда и промышленная

экология. – 2009. -№ 12. – С. 38-47.

4. Коктышев И.В. Современные закономерности патологической

пораженности тяжелыми хроническими болезнями подростков-мужчин в

условиях Донбасса / И.В. Коктышев //Архив клинической и экспериментальной

медицины. – 1999. – Т. 8. - № 1. - С. 120-124.

5. Кундиев Ю.И. Современные проблемы медицины труда в Украине:

наука и практика (обзор литературы и собственных исследований) /

Ю.И. Кундиев, В.И. Чернюк // Журн. АМН Украины. – 2002. – Т. 8. - № 2. –

С. 335-345.

15

mailto:[email protected]%3C

6. Логинов С.Н. Распространенность заболеваний слухового анализатора

и роль аудиологического скрининга у детей северных районов Читинской

области: Автореферат дисс. …канд. мед. наук. – М., 2005. – 21 с.

7. Панкова В.Б. Актуальные проблемы профпатологии ЛОР органов /

В.Б. Панкова // Вестник оториноларингологии. - 2009. - № 6. – С. 5-9.

8. Ревич Б.А. Экологическая эпидемиология: Учебник для высших

учебных заведений // Б.А. Ревич, С.Л. Авалиани, Г.И. Тихонова. – М.:

Издательский центр «Академия», 2004. – 384 с.

9. Шидловская Т.А., Шевцова Т.В. Показатели субъективной аудиометрии

у рабочих с малым стажем работы в шуме / Т.А. Шидловская, Т.В. Шевцова //

Российская оториноларингология. – 2009. -№ 4 (41). – С. 158-152.

10. Margolis R.H. Screening tympanometry: criteria for medical referral /

R.H. Margolis, J.W. Heller // Audiology. - 1987. - Vol. 26. - P. 197-208.

I n f o r m a t i o n a b o u t t h e a u t h o r :

Petrova Natalia Nikolaevna – candidate of medical sciences, assistant-

professor of the Department of Otolaryngology Herald Mechnikov Saint-Petersburg

State Medical Academy, tel. 8(812) 543-94-13, e-mail: [email protected]


1280 ЭлиовичUDC 613.6:614.1

© I.G. Eliovich, S.A. Gorbanev, A.S. Nekhoroshev, 2010

Eliovich I.G.1, Gorbanev S.A.1, Nekhoroshev A.S.2 On regional information

databases of social-hygienic monitoring improvement // Preventive and clinical

medicine. – 2010. - № 1 (34). – Р.17-20.1Leningrad’s oblast administration of rospotrebnadzor, Russia, 192029, Saint-

Petersburg, Olminskogo st. 27, phone number: 8(812)365-35-80, fax: 8(812)365-18-

00. E-mail: 47.rospotrebnadzor.ru

16


2Saint-Petersburg state medical academy named after I. I. Mechnicov, Saint-



S u m m a r y : For improving regional information databases of social and

hygienic monitoring it is necessary to search extra information providers which

indicates about influence of environmental aspect on population health, including

objective appraisal of labour conditions to working man. Creation mechanisms of

using valid results of systems production control in social and hygienic monitoring. It

is important problem solving about compatibility and adequacy of data ware. One of

the methods which did not find proper introduction in system of social and hygienic

monitoring up to date ,is production control carrying out by plant facilities and forces

of accredited laboratories.

K e y w o r d s : social and hygienic monitoring; production control;

information databases.


Eliovich Joseph Georgievich – deputy head, Rospotrebnadzor,s territorial

administration – deputu Chief State Sanitary Officer of Leninqrad Oblast. Tel.

8(812)365-18-00, e-mail: rospotrebnadzor.ru

Gorbanev Sergey Anatolyevich – doctor of medicine, head, Rospotrebnadzor,s

territorial administration - Chief State Sanitary Officer of Leninqrad Oblast. Tel.

8(812)365-18-00, e-mail: rospotrebnadzor.ru

Nekhoroshev Alexander Sergeyevich - doctor of medicine, professor,

department of preventive medicine Saint-Petersburg state medical academy named

after I.I. Mechnicov. Tel. 8(812)545-13-39, fax: 8(812)545-13-39, e-mail:

[email protected]


1287 Щербук

UDC 614.39:617.5-089:616-036.82

© A.Yu. Shcherbuk, L.L. Bashkov, V.V. Donskov, 2010

17

mailto:[email protected]%3C

Shcherbuk A.Yu.1, Bashkov L.L.2, Donskov V.V.2 Experience of regenerative

treatment organization in a megacity in patients surviving hi-tech operations //

Preventive and clinical medicine. – 2010. - № 1 (34). – Р.20-24.1Saint-Petersburg State University. Russia, 191186, St.-Petersburg, Tulenina

str., 4-47. Теl.: 8(812)756-99-35. E-mail: [email protected] on Public Health Services of St.-Petersburg. Russia, St.-Petersburg,

Kostushko str., 1/1. Теl.: 8(812)595-89-55. E-mail: [email protected]

S u m m a r y . Data on the results of the restorative treatment of patients

surviving surgical operations in St.-Petersburg are analyzed. The role of new

organizational technologies, modern medical equipment and effective corrective

procedures in improving the quality of restorative treatment is shown. The main areas

of the practical activities are presented, allowing improving the quality of restorative

treatment of patients who have tolerated hi-tech surgical operations, shortening the

period of their disability and frequency of their incapacity.

K e y w o r d s : public health services; operation; incapacity; restorative

treatment.

R e f e r e n c e s

1. Бобровницкий И.П. Методология разработки и внедрения в практику

инновационных технологий восстановительной медицины / И.П. Бобровницкий

// Актуальные проблемы восстановительной медицины, курортологии и

физиотерапии: Материалы Международного конгресса «Здравница-2008»,

Москва, 21-24 мая 2008г. – С 11-14.

2. Бодрова Р.А. Восстановительное лечение нейротрофических

нарушений у больных с травмами спинного мозга / Р.А. Бодрова, Г.И. Ахметова

// Материалы Всероссийского научного форума по восстановительной

медицине, лечебной физкультуре, курортологии, спортивной медицине и

физиотерапии «РеаСпоМед2008», Москва, 27-29 февраля 2008 г. – С. 30.

3. Заболотных И.И. Особенности ограничения жизнедеятельности

пациентов с патологией внутренних органов по Санкт-Петербургу в 2005 г. /

И.И. Заболотных, Р.К. Кантемирова, А.В. Абросимов // Одиннадцатый

18



Российский национальный конгресс «Человек и его здоровье», ортопедия-

травматология-протезирование-реабилитация: Материалы конгресса. – СПб. –

2006. – С. 139.

4. Карасева Л.А. Состояние инвалидности, потребностей и особенностей

социальной реабилитации инвалидов в Санкт-Петербурге / Л.А. Карасева,

О.Н. Владимирова, Ю.Л. Гусак // Вестник всероссийской гильдии протезистов-

ортопедов. Специальный выпуск. Научное издание. Тезисы докладов XIV

Российского национального конгресса «Человек и его здоровье» - СПб, 2009. -

№ 3 (37). - С. 141-142.

5. Каусова Г.К. Организация и эффективность реабилитации в

медицинских учреждениях / Г.К. Каусова // Проблемы социальной гигиены,

здравоохранения и истории медицины. – 2002. – № 6. – С. 32-33.

6. Сидорович И.А. Возможности дневного стационара амбулаторно-

поликлинического учреждения в лечении больных хирургического профиля /

И.А. Сидорович // Военно–медицинский журнал. – 2002. – № 8. – С. 9-11.

7. Шихова Е.В. Клинико-экономический анализ амбулаторных

реабилитационных программ у больных ишемической болезнью сердца /

Е.В. Шихова // IX Всероссийская научно-практическая конференция

«Актуальные вопросы клиники, диагностики и лечения больных в

многопрофильном лечебном учреждении». – Материалы конференции 21-22

апреля 2009 года. - Вестник Российской военно-медицинской академии,

Приложение. – 2009. - № 1 (25). - Часть II. – С. 561.

8. Щепин О.П. Современные региональные особенности здоровья

населения и здравоохранения России / О.П. Щепин, И.А. Купеева, В.О.Щепин.

– М.: ОАО «Издательство «Медицина», издательство «Шико», 2007. – 360 с.

9. Щербук Ю.А. Организация высокотехнологичной помощи в Санкт-

Петербурге / Ю.А. Щербук, О.А. Гриненко, А.Х. Алборов // «Здоровье – основа

человеческого потенциала: проблема и пути их решения»: Труды 4-й

Всероссийской научно-практической с международным участием. – СПб.:

Вести, 2009. - С. 452-454.

19

10. Ярошенко В.П. Принципы медицинской реабилитации раненных с

патологией внутренних органов в условиях реабилитационного центра /

В.П. Ярошенко, А.М. Щегольков, С.А. Белкин // Современные подходы к

медико–психологической реабилитации лиц опасных профессий: Тезисы

докладов 4-й Всероссийской научно – практической конференции, Москва, 11 –

12 ноября 2004 г. – М., 2004. – С. 55-56.

11. Grill E. Care Set development for the acute hospital and early post-acute

rehabilitation facilities / E. Grill, T. Ewert, S. Chatterji // Disabil. Rehabil. – 2005. –

Vol. 27. – Р. 361-366.

12. Saeki S. Concurrent validity of the community integration questionnaire in

patients with traumatic brain injury in Japan / S. Saeki, T. Okazaki, K. Hachisuka // J.

Rehabil. Med. – 2006. – Vol. 38. – Р. 333-335.

13. Stolwijk-Swuste J.M. Impact of age and co-morbidity on the functioning of

patients with sequelas of poliomyelitis: a cross-sectional study / J.M. Stolwijk-

Swuste, A. Beelen, G.J. Lankhorst // J. Rehabil. Med. – 2007. – Vol. 39. – Р. 56-62.

14. Zang L. Comparison of the Community Integration Questionnaire, the

Craig Handicap Assessment and Reporting Technique and the Disability Rating Scale

in traumatic brain injury / L. Zang, B.C. Abreu, V. Gonzales // J. Head Trauma

Rehabil. – 2002. – Vol. 17. – Р. 497-509.


Scherbuk Alexander Yurievich - Candidate of Medical Sciences, Assistant

Professor of the department of Neurosurgery and Neurology of the Medical Faculty

of St.-Petersburg State University,

Bashkov Leonid Leonidovich - head of the department of Restorative Medicine

of Committee on Public Health Services of St.-Petersburg,

Donskov Victor Vasilievich - Candidate of Medical Sciences, head of the

Organizational-Methodical department on Realization of the Priority National Project

"Health",


20

1305 Морозько

UDC 614.2-052.63:378:796

© P.N. Morozko, 2010

Morozko P.N. Assessment of health and the academic progress of sports high

school students // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.24-29.

State Educational Establishment of Higher Professional Training «Mechnikov

Saint-Petersburg State Medical Academy of the Federal Agency for Public Health

and Social Development of the Russian Federation», 195067, Russia, St.-Petersburg,

K-67, Piskarevsky prospect, 47, tel. (812) 543-96-09, fax: (812) 740-15-24, e-mail:

[email protected]; www.mechnik.spb.ru

S u m m a r y : Influence of factors of residing characterizing condition

lifestyle, pressure of educational sports-training activity and value judgment of the

health on the general disease and the academic progress of students among students

of sports high school were studied. The most essential negative factors are: the shirk

through illness more than 7 days per year, a self-estimation of the health are not

above satisfactory, sensation of weariness after employment in high school,

participation in competitions of three and more times per year lasting more than 30

days, smoking, the alcohol use, not observance of a mode of a dream and a food.

K e y w o r d s : health; morbidity; lifestyle; condition of life; sport;

academic progress.

R e f e r e n c e s

1. Алфимов Н.Н. О расчете коэффициентов множественной корреляции и

детерминации при проведении мониторинга состояния здоровья

военнослужащих (проблемы оценки и прогнозирования здоровья

военнослужащих в условиях современной военной реформы) / Н.Н. Алфимов. –

СПб.: ВМА, 1995. – 40 с.

2. Алфимов Н.Н. Эколого-гигиенические основы прогнозирования

состояния здоровья студентов-спортсменов. Методические рекомендации /

21

http://www.mechnik.spb.ru/


Н.Н. Алфимов, П.Н. Морозько. – СПб.: СПбГАФК им. П.Ф. Лесгафта, 2002. –

33 с.

3. Батрымбетова С.А. Основные тенденции обращаемости студентов за

медицинской помощью / С.А. Батрымбетова // Здравоохранение Российской

Федерации. – 2008. – № 3. – С. 25-26.

4. Кучеренко В.З. Применение методов статистического анализа для

изучения общественного здоровья и здравоохранения: Учебное пособие для

практических занятий / Под ред. В.З. Кучеренко. – М.: ГЭОТАР-Медиа, 2006. –

192 с.

5. Лисовский В.А. Человек, экология, питание и здоровье /

В.А. Лисовский, О.Д. Голощапов, И.М. Мухин. - СПб.: Наука, 2002. – 203 с.

6. Мерков А.М. Санитарная статистика (пособие для врачей) /

А.М. Мерков, Л.Е. Поляков. - М.: Медицина, 1974. – 384 с.

7. Морозько П.Н. Социальный медико-педагогический статус

абитуриентов и студентов факультета «адаптивная физическая культура»

(Монография) / П.Н. Морозько. - СПб.: СПбГМА им. И.И. Мечникова, 2004. –

114 с.

8. Морозько П.Н. Спортивная гигиена. Гигиено-экологическое

прогнозирование состояния здоровья военнослужащих: Учебное пособие / П.Н.

Морозько. – СПб.: ВИФК, 2005. – 34 с.

9. Розенфельд Л.Г. Здоровье студентов по данным субъективной оценки и

факторы риска, влияющие на него / Л.Г. Розенфельд, С.А. Батримбетов //

Здравоохранение Российской Федерации. – 2008. – № 4. – С. 38-39.


Morozko Petr Nikolaevich – candidate of medical sciences, assistant-professor

of the Department of public health and public health service of St-Petersburg state

medical academy after named I.I. Mechnikov. Тel.: 8(812) 543-02-32, e-mail:

[email protected]


22

MOTHER AND CHILDHOOD PROTECTION

1297 Самодова

UDC 616-053.4:616-053.5

© I.L. Samodova, V.S. Luchkevich, 2010

Samodova I.L., Luchkevich V.S. Medical-social characteristic of children

deprived of parental care and assessment of rehabilitation actions efficacy //


State Educational Establishment for High Professional Training «Saint-

Petersburg State Medical Academy after named I.I. Mechnikov of the Federal

Agency for Public Health and Social Development of the Russian Federation».

Russia, 195067, Saint-Petersburg, Piskarevskiy pr., 47. Tel. (812) 543-96-09, fax:

(812) 740-15-24, E-mail: [email protected]

S u m m a r y : The article gives particular social and hygienic operation of

children's group health and social risks, assessed the health status and analysis of

dynamics of quality of life, we have proved the effectiveness of medical and social

rehabilitation of children at risk.

K e y w o r d s : medical and social rehabilitation; quality of life; children of

medico-social risk.

R e f e r e n c e s

1. Альбицкий В. Ю. Возможности использования критериев качества

жизни для оценки состояния здоровья детей / В. Ю. Альбицкий,

И. В. Винярская // Российский педиатрический журнал. - 2007. - N 5. - С. 54-56.

2. Методы исследования развития ребенка: Качество жизни (QOL) –

новый инструмент оценки развития детей / В.И. Гордеев, Ю.С.

Александрович // Санкт-Петербург, 2001. – 25 с.

3. Новик А.А. Руководство по исследованию качества жизни в медицине /

А.А. Новик, Т.И. Ионова; под ред. акад. РАМН Ю.Л. Шевченко. – М.: ОЛМА,

2007. – 320 с.

23


4. Орел В.И. Современные аспекты формирования здоровья детей и меры

по его сохранению и укреплению / В.И. Орел, О.Л. Грандилевская,

И.Ю. Стволинский // Социальные и организационные проблемы педиатрии. –

М.: Династия, 2003. – С. 48-64.

5. Черюканов А.В. Динамика качества жизни несовершеннолетних в

зависимости от объема медицинской реабилитации / А.В. Черюканов,

Е.А. Пинаева, В.С. Лучкевич // Вестник межнационального центра

исследования качества жизни. - 2007. - Т. 9-10. – С. 46-52.


Samodova Inna Leonidovna – assistant of the Department of Public Health and

Public Health Services of Mechnikov Saint-Petersburg State Medical Academy. Тel.:

(812) 543-02-32, e-mail: [email protected]

Luchkevich Vladimir Stanislavovich – The honoured executor of a science of

therussian Federation, the doctor of medical science, the professor, the chief of the

Department of Public Health and Public Health Services of Mechnikov Saint-

Petersburg State Medical Academy. Тel.: (812)543-19-46, e-mail:

[email protected]


1179 Уринбаева

UDC 618.396:616.155.2

© N.A. Urinbaeva, S.N. Sultanov, S.S. Sirozhiddinova, 2010

Urinbaeva N.A., Sultanov S.N., Sirozhiddinova S.S. Assessment of

endotheliocytes and thrombocytes functional state in a threat of miscarriage //


Scientific Research Institute of Obstetrics and Gynecology of the Ministry of

Health of the Republic of Uzbekistan 70000, Tashkent, Kh.Abdullaev str., 132 А,

tel.: 8(371) 263-78-30.

S u m m a r y : The functional condition of endotheliocytes and thrombocytes

are investigated in 44 pregnant women with treat of pregnancy interruptions and in

24



the group of comparison of 14 pregnant women with physiological course of

gestation. The increase in quantity if desquamated endotheliocytes in parallel with

thrombocytes hypofunction is revealed in treat on interruption of pegnancy.

K e y w o r d s : endotheliocytes; thrombocytes; treat of pregnancy

interruption.

R e f e r e n c e s

1. Кузник Б.И. Иммуногенез и неспецифическая резистентность

организма / Б.И. Кузник, Н.И. Цыбиков, Н.В. Васильев. – М.: Медицина, 1989. –

320 с.

2. Серов В.Н. Акушерская патология и синдром системного

воспалительного ответа / В.Н. Серов // Российский медицинский журнал. -

2006. - №2. - С. 741-743.

3. Султанов С.Н. Функциональное состояние эритроцитов и плазменных

белков крови у беременных, рожениц и родильниц, страдающих

железодефицитной анемией / С.Н. Султанов, М.В. Ким, А.А. Хаджиметов //

Мед. журнал Узбекистана. – 1991. - №5. - С. 48-51.

4. Adams B. Plasma atrial natriu retic peptide levels in preeclampsia and

eclampsia / B. Adams, E. Malatyalioglu // L.Matern.Fetal.Jnvest. – 1998. – Vol. 2 –

P. 85-88.


Urinbaeva Nilufar Abdujabbarovna – the candidate of medical sciences (PhD),

obstetrician – gynecologist of the Republican Perynatal center. Phone: 8(371) 761-

50-50.

Sultanov Saidasim Nosirovich – doctor of medical sciences, professor, director

of Scientific Research Institute of Obstetrics and Gynecology of the Ministry of

Health of the Republic of Uzbekistan. Phone: 8(371) 263-78-30.

Sirozhiddinova Sanobar Sabirdjanovna - obstetrician – gynecologist of the

Maternity Home 9, the competitor of Scientific Research Institute of Obstetrics and

Gynecology of the Ministry of Health of the Republic of Uzbekistan. Phone: 8(371)

157-70-05.

25


HYGIENE OF THE SURROUNDING AND INDUSTRIAL ENVIRONMENT

1238 Чернушевич

UDC 616.7/616.084

© N.I.Chernushevich, 2010

Chernushevich N.I. Upper extremities functional state in persons working in

trades with various kinds of physical activity // Preventive and clinical medicine. –

2010. - № 1 (34). – Р.35-38.

North-West Public Health Research Center (Federal Service for Consumer’s

Rights Protection and Human Well-being). 191036 St-Petersburg, 2-ya Sovetskaya,

4, tel. 8 (812) 7179469, Fax: 8(812) 7170264, e-mail: [email protected]

S u m m a r y : the state of upper extremities microcirculation was studied in

168 computer users, 98 jewelry polishers and 64 metal hull assemblers. The

dependence of upper extremities microcirculation disturbances on manifestation

degree of manual physical load was revealed.

K e y w o r d s : physical workload; hands and forearms microcirculation.

R e f e r e n c e s

1. Иванов Л.Б. Лекции по клинической реографии / Л.Б. Иванов, В.А.

Макаров. – М.: Научно-медицинская фирма МБН, 2000. - 320с

2. Профессиональная заболеваемость в Ленинграде - Санкт-Петербурге за

20 лет (1982-2001). С-Пб, 2003. - 150с.

3. Руководство по гигиенической оценке факторов рабочей среды и

трудового процесса. Критерии и классификация условий труда. Руководство Р

2.2.2006-05.– СПб.: ЦОТПБСППО, 2005. – 144с.


26


Chernushevich N.I. – physician, North-West Public Health Research Center

(Federal Service for Consumer’s Rights Protection and Human Well-being). Office

phone: 8 (812) 7179469, home phone: 8 (812) 3071628. e-mail: [email protected]


1318 Фигуровский

UDC 613.6:676.6/.7

© A.P. Figurovsky, N.A. Mozzhukhina, L.A. Alikbaeva, D.P. Khomulo,

M.A. Ermolaev-Makovskii, 2010

Figurovsky A.P., Mozzhukhina N.N., Alikbaeva L.A., Khomulo D.P.,

Yermolaev-Makovsky M. A. Hygienic characteristic of working conditions at

manufacturing chipboard // Preventive and clinical medicine. – 2010. - № 1 (34). –

Р.38-41.

State Educational establishment of Higher Professional training “Mechnikov


and Social Development of the Russian Federation”, Russia 195067, St. Petersburg,

Piskarevskiy etc., etc. 47. Tel.: 8 (812) 543-96-09, fax: (812) 140-15-24. E-mail:

[email protected]

S u m m a r y : The workshop conditions in the production of recycled paper

cardboard should be classified as harmful on the basis of inconsistency levels of

hazardous occupational factors

K e y w o r d s : workshop conditions, hazardous occupational factors,

technological process

R e f e r e n c e s

1. Дулькин Д.А. Мировые тенденции в развитии техники и технологии

переработки макулатуры / Д.А. Дулькин, И.Н. Ковернинский, В.И. Комаров,

В.А. Спиридонов. – Архангельск: Изд-во АГТУ, 2002. – 108 с.

2. Смайлова Л.Ф. Зависимость между концентрацией пыли и

микрофлорой воздуха в цехе по производству гофротары / Смайлова Л.Ф.//

27


Бюллетень Научного Совета «Медико-экологические проблемы работающих».

– 2006.- №3.- С.44-48.

3. Hubbe M.A. Minimizing the environmental impact of the papermaking

process./ Hubbe M.A.// Proceedings of the 2nd IPEC Conference. - Tianjin, China,

2008. - Book A. - P.47-40.

4. Hubbe M.A., Rojas O.J. The paradox of papermaking //

Chem.Eng.Education. - 2008. - Vol.39. - №2. - P.146-155.

5. Pultz H.J. Recyclability of paper and board products // International

Paperworld IPW. - 2007. - № 4. - P.37-43.

I n f o r m a t i o n a b o u t a u t h o r s :

Figurovsky Andrei Pavlovich - candidate of medical sciences, associate

professor of general, military, radiation hygiene and medical ecology department of

Mechnikov St.-Petersburg State Medical Academy . Office tel.8 (812) 543-17-55, E-

mail: [email protected])

Mozzhukhina Natalia Alexandrovna - candidate of medical sciences, associate

professor of department of preventive medicine of Mechnikov St.-Petersburg State

Medical Academy . Office tel. 8 (812) 543-17-47, E-mail: [email protected]

Alikbaeva Lilia Anatolievna. – doctor of medicine, head of general, military,

radiation hygiene and medical ecology department of Mechnikov St.-Petersburg State


Khomulo Dmitri Pavlovich – candidate of medical sciences, associate

professor of military and extreme medicine of Mechnikov St.-Petersburg State


Ermolaev-Makovskii Mikhail Alexandrovich – post-graduate research student ,

military, radiation hygiene and medical ecology department of Mechnikov St.-

Petersburg State Medical Academy . Office tel 8 (812) 543-17-55, E-mail:

[email protected]


1255 Исраилова

28





UDC 614.31:636/638-77-07:613.281:613.1+574

© G.M. Isrаilova, S.T. Eshmuradova, I.E. Turaev, 2010

Israilova G.M, Eshmuradova S.T., Turaev I.E. Hygienic evaluation of risk

factors of contamination of dairy and meat products manufactured under water

shortage conditions // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.41-

43.

Tashkent Institute of Post Graduate Medical Education The Ministry of Health

of The Republic of Uzbekistan, 700007, Republic of Uzbekistan, Tashkent,

Parkentskaya St, 51, Tel.: 8(371)268-17-10, 8(371)268-23-08, Fax.: 8(371)268-17-

10. E-mail: [email protected], или [email protected].

S u m m a r у : Potential areas on livestockfarmi have been divided into 3

zones depending on conditions of their manufacture for future comparative analysis

of quality, food and biological value of the products from meat and milk, are

producible in shallowness environment. Study of forage crops, waters for animals, as

well as indicators for food and biological value of the products from meat and milk

had generated a need for experts to draw attention to criteria of safety and on food

and biological value of production are producible in shallowness environment.

K e y w o r d s : safety; milk; meat; hygiene of nutrition; sanitary inspection;

stock raising; hygienic study.

R e f e r e n c e s

1. Иванова Т.Н. Содержание токсических элементов в некоторых видах

растений / Т.Н. Иванова, Д.А. Павловская, В.М. Кузьмин // Гигиена и

санитария. - 1997. - № 1. - С. 22-25.

2. Истомин А.В. Гигиенические аспекты безопасного применения

агрохимикатов / А.В. Истомин, Т.В. Юдина, Н.И. Николаева, Р.С. Хамидулин //

Вопросы питания. - 1999. - № 4. - С. 41-44.

3. Мудрый И.В. Гигиеническая оценка химического загрязнения почвы и

качества сельскохозяйственных культур в условиях орошения сточными

водами / И.В. Мудрый // Гигиена и санитария. - 1997. - № 5. - С. 9.

4. СанПиН Республики Узбекистан №0138-03. Санитарные нормы

29



безопасности и пищевой ценности продовольственного сырья и продуктов

питания. - Ташкент: Ибн Сина, 2003. - 183 с.

5. Сидоренко Г.И. Экология человека и гигиена окружающей среды на

пороге XXI века / Г.И. Сидоренко, С.М. Новиков // Гигиена и санитария. - 1999.

- № 5. - С. 3.

6. Тутельян В.А. Питание в борьбе за выживание / В.А. Тутельян,

Б.П. Суханов, М.М. Гаппаров. – М.: ИКЦ «Академкнига», 2003. - 437 с.

7. Худайберганов А.С. Современные аспекты медико-биологических

факторов и критериев здорового питания / А.С. Худайберганов, Б.А. Рискиев,

М.М. Рузиева, А.К. Турсунбаев // Проблемы биологии и медицины. - 2005. -

№ 3 (41). - С. 185-187.


Israilova Gulida Maratovna - The candidate of medical sciences, the senior

teacher of chair "Hygiene" of the Tashkent Institute of Post Graduate Medical

Education The Ministry of Health of The Republic of Uzbekistan, Tel.: 8(371)268-

17-10, 8(371)268-23-08, Fax: 8(371)268-17-10.

Eshmuradova Saboat Tursunovna - The competitor of chair "Hygiene" of the

Tashkent Institute of Post Graduate Medical Education The Ministry of Health of The

Republic of Uzbekistan Tel.: 8(371)268-17-10, 8(371)268-23-08.

Turaev Ilhom Eshmuradovich - The competitor of chair "Hygiene" of the

Tashkent Institute of Post Graduate Medical Education The Ministry of Health of The

Republic of Uzbekistan, Tel.: 8(371)268-17-10, 8(371)268-23-08.


1247 ХамракуловаUDC 615. 963. 95: 613

© M.A. Кhamrakulova, 2010

Khamrakulova M.A. Carbohydrate-energy metabolism disorders in the liver

under the influence of decys pesticide and their correction by introduction of

30

biologically active substances // Preventive and clinical medicine. – 2010. - № 1 (34).

– Р.43-47.

Research scientific institute of sanitation, hugien and predeceases Ministry of

health Republic of Uzbekistan, 700056, Tashkent, Oltin-tepa str., 325, tel: 8-371-266-

69-52, fax: 8-371-266-47-36, Е-mail: [email protected]

S u m m a r y : The influence of pesticide decis much times to white rats in

dose 4,12 mg/kg in conditions high temperature of air discovered disorders of

carbohydrate-energetic exchange, expressing in pyruvic and lactic acid, depression of

activity ferments degidrogenas (GDG, SDG, MGD) and sitochromoxydas and reduse

intensivity of tissue breathing and oxidative phosphorylation in liver. Introduction

complex of biologically active substance promotes correction of metabolic processes

for carbogydrate-energic metabolism

K e y w o r d s : pesticide decis; toxicology; mechanism of carbohydrate

energetic metabolism; correction; biologically active substance; high temperature.

R e f e r e n c e s

1. Кливченко Р.С. Определение активности цитохромоксидазы //

Современные методы в биохимии. – 1971. – С.45-46.

2. Определение пировиноградной кислоты в крови, модифицированным

методом Умбрайта // Биохимические методы исследования в клинике. – 1969. –

С.254-255.

3. Покровский А.А., Арчаков А.И., Герасимов А.М. Определение

активности глутаматдегидрогеназа // Современные методы в биохимии. – 1968.

– С.43-44.

4. Садиков А.У, Хамракулова М.А, Искандарова Г.Т., Элинская О.Н.,

Садиков У.А. определение активности сукцинатрогеназы в сыворотке крови и

митохондриях. // Методические рекомендации. некоторые метаболических

механизмы биоэнергетики и методы определения раннего выявления

патологических процессов при интоксикации пестицидом децисом //Утв.

Заместителем Министра Здравоохранение РУз, 2004 –С.6-8.

31


5. Садыков А.У., Хамракулова М.А., Искандарова Г.Т, Элинская О.Н.,

Садиков У.А. определение активности малатдегидрогеназы. // Методические

рекомендации некоторые метаболические механизмы биоэнергетики и методы

определения раннего выявления патологических процессов при интоксикации

пестицидом децисом // Утв. Заместителем Министра Здравоохранение РУз.

2004-С.8-10.

6. Садиков А.У., Хамракулова М.А, Искандарова Г.Т. Методы определения

окислительного фосфолирования в токсикологии // Методические

рекомендации, 1997 Утв. Минздравом Республики Узбекистан, 1997.

7. Хамракулова М.А. Особенности воздействия пестицида мезон на обмен

веществ в ткани печени // Бюллетень Ассоциации врачей Узбекистана. – 2000. -

№ 1. – С.102-104.

8. Meeker J., Barr D., Hauser R. Pyrethroid insecticide metabolites are

associated with serum hormone levels in adult men // Reprod 2009. Apr; -P.155-160.

9. Scollon E., Starr J., Godin S., De Vito M., Hughes M. In vitro metabolism of

pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450

isoforms // Drug metab dispos. North Caroline 2009 Jan.-P.221-228.


Кhamrakulova Muqaddas Asqarovna – candidate of medical sciences, elder

scientist of RSI of sanitation, hugien and predeceases Ministry of health Republic of

Uzbekistan, work tel: (8-371) 266-69-52 home tel: (8-371) 266-49-50, mobile phone

99-897-154-45-15 E-mail: [email protected], Hamrakulova @inbox.ru


NEW TECHNOLOGIES, METHODS OF DIAGNOSTICS, TREATMENT AND PREVENTION IN PUBLIC HEALTH SERVICES

1310 Николаев

UDC 616.89:612.821.3:616.1

32


© V.I. Nikolaev, M.D. Denisenko, 2010

Peculiarities of the emotional tension formation and haemodynamic changes in

human body as a response to psychoemotional stress

V.I. Nikolaev, M.D. Denisenko

Mechnikov Saint-Petersburg State Medical Academy, Saint-Petersburg, Russia

Nikolaev V.I., Denisenko M.D. Special characteristics of emotional tension and

hemodynamic change in man during psychoemotional stress // Preventive and clinical

medicine. – 2010. - № 1 (34). – Р.47-50.

State Educational Establishment of Higher Professional Training “ Mechnikov


and Social Development of the Russian Federation ”, 195067, St.-Petersburg, K-67,

Piskarevsky prospect, 47, tel. (812543-96-09, fax: (812140-15-24, e-mail:

[email protected]; [email protected]; www.mechnik.spb.ru

S u m m a r y : the peculiarities of the emotional tension formation were

revealed and the changes of the central haemodynamics as a response to

psychoemotional stress were assessed. 186 healthy volunteers (at the age of 19-25,

male and female) were examined when they were calm and when they experienced

the emotional stress. The dynamics of the emotional state (by assessing the indicators

of anxiety, aggression, depression) and the changes of the haemodynamics (by using

the integral rheography of the body) were researched. The results of our experiment

showed that the value and the focus of the haemodynamic processes depend not only

on expression of the forming tension, but also on individual characteristics and

peculiarities of the organism.

K e y w o r d s : adaptation, psychoemotional tension, emotional dynamics,

central haemodynamics, type of the blood circulation, anxiety.

Significant and constantly growing loading on psychoemotional apparatus of a

modern person makes extreme demands to the systems of adaptation and can lead to

the overtension of the regulative mechanisms [8]. Character of the body responses

depends on physiological activity of nervous, endocrine and cardiovascular systems

33

[7]. Mechanisms of the development of general adaptive syndrome (GAS) -

nonspecific response of an organism - are identical for various individuals. Despite of

the generality of typical adaptive reactions to adverse influences experimental

supervisions show, that there are groups of people possessing certain stability to

emotional stress. Individuality of reactions depends on many factors of the external

and internal environment and, first of all, from genetically caused properties of

systems of adaptation, and also from psychological peculiarities of a person [1,5].

Recently the concept of so-called «negative affectation» is introduced in

modern literature. “Negative affectation” means tendency to experience negative

emotions and to create the negative "I-concept", including the most significant

negative feelings - anxiety, depression and aggression, - emotions, very often

developing under the influence of stress-factors [3]. People with high negative

affectation experience distress, discomfort and dissatisfaction in the situations even

when vital circumstances as a whole are favorable for a person [6]. The question

about the connection between haemodynamic peculiarities of regulation and changes

of an emotional state is still not solved. Emotional dynamics is the change of

manifestations of personal properties in conditions of stress in comparison with an

initial condition. It can be positive (when expressiveness of individual properties

grows during stress) or negative (when the initial level of personal peculiarities

display is higher, than during stress). It is not known which dynamics is adaptive,

useful to an organism. The question about the role of emotional dynamics as a trigger

mechanism of individual adaptation is not investigated in general, especially there are

no information about functional changes in effector (cardiovascular system) and

regulative systems of an organism. There are no full data on distribution of types of

blood circulation among people with different variants of the emotional answer

(bearing in mind such individual properties as anxiety, aggression, depression).

T h e p u r p o s e o f t h e r e s e a r c h : is to reveal and assess changes

of central haemodynamics during emotional stress among people with different types

of emotional state.

34

M a t e r i a l s a n d m e t h o d s o f t h e r e s e a r c h : the

emotional state was examined in our research: anxiety (personal (Ap), reactive (Ar)),

aggression were assessed by the scale of Spielberg - Khanin; the level of depression

was defined by the questionnaire of V.Zung; the vegetative index of Kerdo (the most

simple parameter of adaptation) was calculated for the definition of sympathetic and

parasympathetic influences of the vegetative nervous system [4]; the index of

functional changes was calculated either [2]. In R.M.Baevskii´s and A.P.Berseneva's

opinion (2008), assessment of a level of functioning (the especial characteristic of a

homeostasis) by using the index of functional changes, at all simplicity, provides the

system approach to the decision of the problem of quantitative measurement of the

health degree. The types of blood circulation were defined with the help of integral

rheography of a body (the computerized monitor complex of cardio-respiratory

system and hydration of tissues, KM - АP-01 Diamant).

Researches were carried out twice: in an initial condition and in a situation of

psychoemotional tension. Exam served as a situation of emotional stress.

186 healthy volunteers (at the age of from 19 till 25 years; 68,8% - female,

31,2% - male) have taken part in the research.

Statistical computing was carried out with the help of parametrical (criterion of

Student) and nonparametric methods (the methods of Wilkokson-White, Shapiro-

Wilkes).

R e s u l t s o f t h e r e s e a r c h a n d d i s c u s s i o n : as a result

of the carried out experiment all examinees have been divided into 3 groups

depending on dynamics of the emotional state. The first group included persons with

equilibrium emotional dynamics (Ap = Ar) - 9 persons, the second group (51

persons) contained examinees with great individual anxiety (personal anxiety was

higher than reactive anxiety - Ap › Ar). The third group submitted by persons with

positive emotional dynamics (Ap ‹ Ar) had the greatest number (126 persons).

In our research statistically significant distinctions between indices in initial

condition and during emotional stress-formation have been revealed at the

comparative analysis of anxiety (personal and situational), depression and aggression.

35

So, in all groups the increase of level of depression (that was the greatest in the third

group - with 34,3 in a background up to 40,9) was marked during examination (р ‹

0,01). The comparative analysis of aggression as an individual peculiarity and

aggression as a reaction to stress situation has shown, that the authentic increase in

parameter of aggression was observed only in the third group (р ‹ 0,05).

The investigation of the correlation of emotional state and peculiarities of the

vegetative balance has revealed close correlation between them.

Assessing the activity of vegetative nervous system it has been established that

activity of parasympathetic nervous system during stress predominated among 55

persons (from the general number examinees), parasympathetic nervous system

prevailed among 120 persons, and 11 individuals showed the balance between the

activity of sympathetic and parasympathetic departments of the vegetative nervous

system. Distribution in groups is submitted on picture 1.

A

the second group, n=57

41,20%

58,80%

B

the first group, n=9

22,20%

77,80%

C

the third group, n=126

25,40%

65,90%

8,70%

predomination ofparasympatheticnervous systempredomination ofsympatheticnervous systemequilibrium ofsystems

Picture 1. Assessment of homeostasis of examinees during emotional stress

In our research persons with domination of parasympathetic regulation

constituted practically half of examinees in the second group (41,2%), and only a

quarter (25,4%) in the third group. According to data presented by L.E.Panin and

V.P. Sokolov (1981), prevalence of tone of parasympathetic nervous system is typical

for “low-anxious” people. Among individuals with high anxiety the index of

sympathetic nervous system dominates. It is known, that the most successful

adaptation is provided with prevalence of sympathetic influences above

parasympathetic.

36

It has been revealed that in the first group tension of the regulative mechanisms

took place among 4 persons (44,4%) during emotional stress, and 1 person (11,1%)

showed unsatisfactory adaptation.

In the second group 36 persons had satisfactory adaptation, 1 person (1,9%)

had unsatisfactory adaptation, 14 persons (27,5%) experienced tension of the

adaptive mechanisms.

In the third group 81 examinees (64,3%) had satisfactory adaptation, 10

persons (7,9%) had unsatisfactory adaptation, tension of the adaptive mechanisms

was observed among 33 persons (26,2%). It is necessary to note, that in this group the

failure of adaptation was revealed among 2 individuals.

Results of the research have shown, that psychoemotional tension revealed

itself by different focus and intensity of changes of the base parameters of the system

of blood circulation.

The peculiarities of haemodynamic changes have been investigated in the

second and in the third groups (the first group was not taken into account because of

small sample for the analysis). In the third group, described by increase of level of

anxiety, the increase of heart rate (on 25%), blood pressure (on 12,5%) were

observed. Thus 54% of examinees were characterized by hyperdynamic type of blood

circulation: cardiac output increased in 25,6%, minute blood volume increased in

60,3%. 46% of examinees showed hypodynamic type o blood circulation: minute

blood volume decreased up to 3,83 l/minute (picture 2А).

A

125 126

170,5

133

76,952,8

0

50

100

150

200

heart rate cardiac output minute blood volume

%

hyperdynamic type hypodynamic type B

135,6119,4

149,5

117,2

50,471,5

020406080100120140160

heart rate cardiac output minute blood volume%

hyperdynamic type hypodynamic type

37

Picture 2. Changes of haemodynamics among examinees of the third group (А)

and the second group (B) during emotional stress (in % in relation to initial state)

The decrease of anxiety (Ap › Ar, however reactive anxiety is regarded as high

in the specific limits), tension of the regulative mechanisms (71,4%), changes in the

functioning of cardiovascular system were observed among individuals with

“negative” emotional balance (the second group) (fig. 2B). During exam all persons

developed tachycardia (in 1,4 times from initial). 57% of all examinees showed the

decrease of arterial pressure or blood pressure without changes. The type of blood

circulation was hypodynamic (with sharp decrease of cardiac output and minute

blood volume) in 43%, normodynamic in 28%, hyperdynamic in 29%.

It is necessary to mention, that quality of the "useful" result (mark for the

exam) was approximately identical in all groups: about 20% of excellent, 60% of

good and 20% of satisfactory marks.

T h e c o n c l u s i o n : apparently, all types of emotional dynamics have

adaptive value. However obtaining the useful result is caused by various types of

psychoemotional reactions with different degree of tension of adaptive processes

which, probably, is determined by different intensity of stress - limiting systems.

Thus it is defined, that the value and the focus of the haemodynamic answer depend

not only on expression of the forming tension, but also on individual - typological

characteristics and peculiarities of an organism.

R e f e r e n c e s

1. Атаман А.В. Патологическая физиология / А.В. Атаман. – Киев: Вища

школа, 2000. – 608 с.

2. Баевский Р.М. Теоретические основы донозологической диагностики /

Р.М. Баевский, А.П. Берсенева // Донозология и здоровый образ жизни. – 2008.

– № 2 (3) – С. 2-13.

3. Брайт Д. Стресс: теория, исследования, мифы / Д. Брайт, Ф. Джонс. –

СПб: Олма-пресс, 2003. – 353 с.

38

4. Панин Л.Е. Психосоматические взаимоотношения при хроническом

эмоциональном напряжении / Л.Е. Панин, В.П. Соколов. – Новосибирск: Наука,

1981. – 176 с.

5. Пшенникова М.Г. Феномен стресса. Эмоциональный стресс и его роль в

патологии / М.Г. Пшенникова // Патологическая физиология и

экспериментальная терапия. – 2000. – № 4. – С. 21-31.

6. Соловьева С.Л. Эмоциональный баланс как критерий

стрессоустойчивости / С.Л. Соловьева, В.И. Николаев // Исследования и

разработки по приоритетным направлениям в медицине: материалы конф.

СПбГМА им. И.И. Мечникова. – СПб, 2008. – С. 237-239.

7. Судаков К.В. Мотивация – основа психической деятельности / Судаков

К.В. // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2006 – № 7. – С.

5-17.

8. Черешнев В.А. Система крови и адаптация организма к экстремальным

факторам / В.А. Черешнев, Б.Г. Юшков, М.Н. Сулин // Российский

физиологический журнал им. И.М. Сеченова. – 2004. Т. 90 – № 10 – С. 1193-

1202.


Nikolaev Valentine Ivanovich - doctor of medicine, chief of the department of

pathological physiology of Saint-Petersburg State Medical Academy named after

I.I.Mechnikov, professor, work tel.: (812)543-16-30.

Denisenko Maria Dmitrievna - post-graduate student of the department of

pathological physiology of Saint-Petersburg State Medical Academy named after

I.I.Mechnikov, work tel.: (812)543-16-30


1321 Минько UDC 616.61-006-089:615.837.3-07

© B.A. Minko, D.G. Prokhorov, A.A. Semeonova, I.V. Shevtsov, 2010

39

Minko B.A. 1, Prokhorov D.G. 1, Semeonova A.A. 2, Shevtsov I.V. 1 Ultrasonic

examination of patients with renal cancer at small-invasive surgical interventions //

Preventive and clinical medicine. – 2010. - № 1 (34). – Р.50-54.1Federal State Institution “Russian Scientific Center of Radiology and Surgical

Technologies” of the Federal Agency for High Tech Medical Aid, FSI “RSCRST of

Rosmedtechnologies”, 197758, Saint-Petersburg, Pesochnyi, Lenigradskaya str., 70,

tel.: 596-84-62; e-mail: [email protected] Educational Establishment of Higher Professional Training «Mechnikov


and Social Development of the Russian Federation», 195067, Russia, St.-Petersburg,

K-67, Piskarevsky prospect, 47, tel. (812) 543-96-09, fax: (812) 740-15-24, e-mail:


S u m m a r y : At the present time according to successes of surgery there is

the possibility of eradicatory low invasive surgical treatment of localized renal

cancer. The problem of a great importance is the selection of patients for saving-

organ operations inclusive of absolute and secondary indications. Complex

ultrasound examination at renal cancer allows to diagnose the character of the renal

blood flow, what is important for exact diagnostics and monitoring after surgery.

K e y w o r d s : renal cancer; ultrasonic investigation; small invasion surgical

interventions.

R e f e r e n c e s

1. Давыдов М.И., Аксель Е.М. Статистика злокачественных

новообразований в России и странах СНГ в 2005г. // Вестник Российского

Онкологического научного центра им. Н.Н.Блохина РАМН, 2007. - Т 18. -

2. Лопаткин Н.А. Руководство по урологии. - М., 1998. - Т. 3. - 672 с.

3. Митина Л.А., Казакевич В.И., Степанов С.О. Ультразвуковая

онкоурология // Под редакцией В.И. Чисова, И.Г. Русакова. - М.: Медиа Сфера,

2005. - 182 с.

4. Pannu H.K., Fishman E.K. Multidetector computed tomographic evaluation

of the renal artery // Abdom. Imaging. - 2002. Vol. 27. - P. 611–619.

40




5. Зубарев А.В. Диагностический ультразвук. // Под редакцией А.В.

Зубарева. - M.: Реальное время, 1999. - 176 c.

6. Аляев Ю.Г., Крапивин А.А. Локализованный и местно-

распространенный рак почки: нефрэктомия или резекция? // Онкоурология.

2005., №1., С.10-14.

7. Wittekind C., Meyer H.-J., Bootz F. (2002) TNM-Klassifikation maligner

Tumoren, 6th edn. Springer, Berlin Heidelberg.

8. Гранов А.М., Давыдов М.И. Интервенционная радиология в онкологии.

– СПб.: Фолиант, 2007. – 324 с.

9. Mouraviev V., Joniau S., Van Poppel H. Polascik T. Current status of

minimally invasive ablative techniques in the treatment of small renal tumours //

Europ. Urol. – 2007. – Vol. 51. – P.328-336 .

10. Johnson D., Solomon S., Li-Ming Su et al. Defining the complications of

cryoablation and radio frequency ablation of small renal tumors: a multi-institutional

review // J.Urol. - 2004. – Vol. 172. – P. 874-877.

11. Farrell MA, Di Marco DC. Imaging-guided radiofrequency ablation of

solid renal tumors. Am. J. Roentgenol. - 2003. – Vol. 180. – P. 1509-1510.

12. Игнашин Н.С., Николаев С.И., Демин А.И. Ультразвуковое

исследование и компьютерная томография в диагностике новообразований

почек // Визуализация в клинике. - 1996. - N 8. - С. 43-47.

13. Lavopierre A.M., Dowling R.J., Little A.F. et al. Ultrasound of the renal

vasculature // Ultrasound Quarterly. - 2000. - Vol. 16. - № 3. - P. 123–132.

14. Зубарев А.В., Гажонова В.Е., Панюшкин С.М. и др. Трехмерная

виртуальная эхоангиография почек // Эхография. - 2001. - Т. 2. № 2. - С. 124–

130.

I n f o r m a t i o n a b o u t a u t h o r s :

Min’ko Boris Alexandrovitch. MD, professor, Chief scientific specialist of the

radiological department of the Radiological Institute. E-mail: [email protected]

Prohorov Denis Georgievitch. Chief scientific specialist of the operative and

endovascular urology of the Radiological Institute.

41


Shevtsov Ivan Vladimirovitch Graduate of the of the operative and

endovascular urology of the Radiological Institute.

Semenova Anna Anatolievna. Sonographer, assistant of the Radiological

department, State medical Academy.


1165 Касумов

UDC 616.8-089 + 616.853

V.R. Kasumov, 2010

Kasumov V.R. Method of subpial transections in a system of surgical treatment

of multifocal epilepsy // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.54-

57.

Federal State Institution «Russian A.L. Polenov Research Neurosurgical

Institute of the Federal Agency for Advanced Technology Medical Aid», 191014, St.-

Petersburg, Mayakovsky Str., 12, tel.: 8(812)272-98-19, fax: 8(812)277-47-70.

S u m m a r y : In a series of 10 multifocal epilepsy patients it was shown that

the data obtained using neurophysiologic and neuroimaging studies made it possible

to localize epileptic foci in functionally important areas to apply the method of

subpial transsection and achieve a stable therapeutic effect.

K e y w o r d s : epilepsy; surgical treatment.

R e f e r e n c e s

1. Гехт А.Б. Современные стандарты диагностики и лечения эпилепсии в

Европе / А.Б. Гехт, Г.Н. Авакян, Е.И. Гусев // Журн. неврол. и психиатр. – 1990.

– № 7. – С. 4–7.

2. Громов С.А. Контролируемая эпилепсия / С.А. Громов. – СПб. : ИНЦ

Балтика, 2004. – 302 с.

3. Земская А.Г. Многоочаговая эпилепсия у детей / А.Г. Земская, Ю.П.

Кривошеина // Актуальные проблемы профилактической и клинической

медицины. – Л., 1975. – С. 158–160.

42

4. Зотов В.Ю. Сравнительная характеристика эпилептических припадков

у больных с одноочаговой и многоочаговой эпилепсией / В.Ю. Зотов // Журн.

неврол. и психиатр. – 1974. – № 6. – С. 821–826.

5. Касумов Р.Д. Применение метода множественных субпиальных

насечек при хирургическом лечении фармакорезистентных парциальных

эпилепсий / Р.Д. Касумов, Т.С. Степанова, В.Р. Касумов // Российско-Японский

нейрохирургический симпозиум : Программа и статьи = Russian-Japanese

Neurosurgical Symposium : Program and lectures / Под ред. В.П. Берснева; ФГУ

«Российский научно-исследовательский нейрохирургический институт им.

проф. А.Л. Поленова Росмедтехнологий». – СПб. : Изд-во «Человек и его

здоровье», 2008. – С. 172–173.

6. Стемпень Л. Операционное лечение многодолевой эпилепсии / Л.

Стемпень, Т. Бача, Е. Бидзиньски, Р. Краевски // Хирургическое лечение

эпилепсии. – Тбилиси, 1985. – С. 31–32.

7. Engel J. Outcome with respect to epileptic seizure / J. Engel, P.C. Van Ness,

T.B. Rasmussen, L.M. Qjeman // Surgical treatment of epilepsies. / Ed. J.Jr. Engel. –

Second edition. – New York. : Raven Press, 1993. – P. 609–621.

8. Hauser W.A. Recent development in the epidemiology of epilepsy / W.A.

Hauser // Acta Neurol. Scand. – 1995. – Vol. 92 (Suppl.). – P. 17–21.

9. Morrell F. Multiple subpial transection : a new approach to the surgical

treatment of focal epilepsy / Morrell, F., W.W. Whisler, T.P. Bleck // J. Neurosurg. –

1989. – Vol. 70. – P. 231–239.

10. Sperry R.W. Physiological plasticity and brain circuit theory // Biological

and Biochemical Bases of Behavior / R.W. Sperry; Ed. H.F. Harlow, C.N. Woolsey.

– Madison (Wis.) : University of Wisconsin Press, 1958. – P. 409.


Kasumov Vugar Raufovich – candidate of medical sciences, chief of the 1st

Neurosurgical Department, A.L. Polenov RNSI, work tel.: 8-812-273-80-67, home

tel.: 8-812-717-53-75, e-mail: [email protected]


43


CLINICAL AND EXPERIMENTAL STUDIES

1223 РезниковаUDC 616.831-007.246-02:616.832-004.2

© T. N. Reznikova, V.I. Semivolos, A.G. Ilves, N.A. Seliverstova, 2009

Reznikova T.N., Semivolos V.I., Ilves A.G., Seliverstova N.A. Characteristics of

intrinsic pattern of illness at demyelination foci localization in the brain of patients

with multiple sclerosis // Preventive and clinical medicine. – 2010. - № 1 (34). –

Р.57-61.

Institute of the human brain, Russian Academy of sciences. Russia, 197376,

Saint-Petersburg, Pavlova str 9., tel.: 8-812-234-92-53, E-mail: [email protected] or

[email protected]

S u m m a r y : Interrelation between localization of demyelination focus and

features of the inner picture of the disease were revealed. With demyelination of the

corpus callosum the disadaptation types of the attitudes to the disease were observed.

The role of the corpus callosum in adaptation to the disease was consider.

K e y w o r d s : multiple sclerosis, inner picture of the disease,

demyelination.

R e f e r e n c e s

1. Алексеева Т.Г. Спектр нейропсихологических нарушений при рассеянном

склерозе / Т.Г.Алексеева, А.Н.Бойко, Е.И.Гусев // Журнал невропатологии и

психиатрии им. С.С. Корсакова. - 2000. - Т.100, №11. - С.15-20

2. Вассерман Л.И. Психологическая диагностика типов отношения к болезни

при психосоматических и нервно-психических расстройствах / Л.И.

Вассерман // Методические рекомендации. -СПб. – 1991. - 23 с.

3. Виноградова Т.В. Внутренняя картина болезни при локальных поражениях

мозга / Т.В. Виноградова // Вестн. МГУ. Серия 14: Психология, - 1979, - №2.

- С. 56-60.

44

4. Коркина М.В. Психологические нарушения при рассеянном склерозе /

М.В.Коркина, Ю.С.Мартынов, Г.Ф.Малков. - М.: Изд-во УДН, 1986. - 123с.

5. Лурия А.Р. Основы нейропсихологии / А.Р. Лурия. – М.: МГУ. 1973. – 374с.

6. Шмидт Т.Е. Рассеянный склероз / Т.Е. Шмидт, Н.Н. Яхно. - М.:

Медицина, 2003. – 160 с.

7. Kawaguchi Y. Receptor subtypes involved in callosally-induced postsynaptic

potentials in rat frontal agranular cortex in vitro / Y. Kawaguchi // Experimental

Brain Research. – 1992. Vol. 88. – P. 33–40.

8. Kinsbourne M. The corpus callosum equilibrates the cerebral hemispheres /

M.Kinsbourne // The Parallel Brain: The Cognitive Neuroscince of the Corpus

Callosum / ed. E.Zaidel, M. Iacoboni. – Cambridge: MIT Press, 2003. –P. 271-

281.

9. Rao S.M. Cerebral disconnection in multiple sclerosis. Relationship to atrophy of

the corpus callosum.Bernardin / S.M. Rao L., G.J. Leo, L.Ellington, S.B. Ryan,

L.S. Burg // Archives of Neurology. – 1989. Vol. 46. - P. 918–920.


Reznikova Tatyana Nikolaevna, doctor of medicine, Saint-Petersburg, Russia,

Institute of the human brain, Russian Academy of sciences, 197376, St.-Petersburg,

Pavlova str 9., tel.: 8-812-234-92-53, E-mail: [email protected]

Semivolos Valentina Ivanovna, ordinator, Institute of the human brain, Russian

Academy of sciences 197376, St.-Petersburg, Pavlova str 9., E-mail: [email protected]

Ilves Alexander Gennadievich - candidate of medical sciences Institute of the

human brain, Russian Academy of sciences 197376, St.-Petersburg, Pavlova str 9.,

tel.: 8-812-234-92-42, E-mail: [email protected]

Seliverstova Natalya Alekseevna - candidate of psychology sciences, 197376,

St.-Petersburg, Pavlova str 9., tel.: 8-812-234-92-53, E-mail: [email protected]


1268 Зборовский

UDC 616.5-036.22

45


©A.B.Zborovsky, B.V.Zavodovsky, N.V.Nikitina, Yu.V.Yashina,

E.V.Budkova, I.V.Doronina, A.B.Pavlova, I.A.Zborovskaya, 2010

Zborovsky A.B.1, Zavodovsky B.V.1, Nikitina N.V.1, Yashina Yu.V.1, Budkova

E.V.1, Doronina I.V.2, Pavlova A.B.1, Zborovskaya I.A.1 Clinical-pathogenetic value

of metabolic syndrome markers determination in patients with osteoarthritis //

Preventive and clinical medicine. – 2010. - № 1 (34). – Р.61-65.1Research Institute for clinical and experimental rheumatology, 400138,

Volgograd, Zemlyatchky str., 76, tel. (8442) 35-56-48, fax: (8442) 93-42-11, E-mail:

[email protected] State Medical University, 400131, Volgograd, Fallen Fighters

Square, 1, tel. (8442) 35-30-62

S u m m a r y . The high level of oxidized low density lipoprotein (OxLDL)

and autoantibodies to OxLDL were revealed in sera of patients with ОА at 60% and

29% of cases accordingly. Thus OxLDL and autoantibodies to OxLDL may have

important significance in pathogenesis of ОА.

K e y w o r d s : oxidized low density lipoprotein, autoantibodies to oxidized

low density lipoprotein, osteoarthritis.

R e f e r e n c e s

1. Лабезник Л.Б. Метаболический синдром и органы пищеварения / Л.Б.

Лабезник, Л.А. Звенигородская. - Москва, 2009. – с.181.

2. Насонова В.А. Остеоартроз – проблема полиморбидности // Consilium

medicum. - 2009. - Том 11. - №2. - С. 5-8.

3. Носкова А.С. Абдоминальное ожирение как фактор развития

остеоартроза коленного сустава. / А.С. Носкова, И.Г. Красивина, Л.Н.

Долгова // Тер. Архив. - 2007. - Том 79. - № 5. - С. 29-31

4. Терешина Е.В. Роль жирных кислот в развитии возрастного

окислительного стресса. Гипотеза / Е.В. Терешина // Успехи геронтологии. -

2007. - Том 20. - №1. – с. 59-64.

46

5. Chen X.P. Lectin-like oxidized low-density lipoprotein receptor-1: protein,

ligands, expression and pathophysiological significance / X.P. Chen // Chin. Med. J.

(Engl). – 2007. - Vol. 120. - № 5. - P. 421-426.

6. Conaghan P.G. Is progressive osteoarthritis an atheromatous vascular

disease? / P.G. Conaghan, H. Vanharanta, P.A. Dieppe // Ann. Rheum. Dis. - 2005. -

Vol. 64 - № 11. - P. 1539-1541

7. Gudimetla P. The influence of lipid-extraction method on the stiffness of

articular cartilage. / P. Gudimetla, R. Crawford, A. Oloyede // Clin. Biomech. - 2007.

- Vol. 22. - № 8. - P. 924-931

8. Nakagawa T. LOX-1 expressed in cultured rat chondrocytes mediates

oxidized LDL-induced cell death-possible role of dephosphorylation of Akt / T.

Nakagawa, T. Yasuda, H. Hoshikawa // Biochem. Biophys. Res. Commun. - 2002. -

Vol. 299. - № 1. - P. 91-97.


Zborovsky Alexander Borisovitch – academic of Russian AMS, deputy

director, work tel.: (8442) 35-56-48

Zavodovsky Boris Valerievich - doctor of medicine, head of laboratory, work

tel.: (8442) 35-29-03, home tel.: (8442) 79-08-11, e-mail:

[email protected]

Nikitina Natalia Valerievna – candidate of medicine, senior scientific worker,

work tel.: (8442) 35-29-51, home tel.: (8442) 31-65-40, e-mail:

[email protected].

Yashina Yulia Victorovna - postgraduate student, work tel.: (8442) 35-29-51.

Budkova Elena Victorovna – junior scientific worker, work tel.: (8442) 35-56-

48.

Doronina Irina Vladimirovna – postgraduate student, work tel.: (8442) 39-43-

05.

Pavlova Alla Borisovna- junior scientific worker, work tel.: (8442) 35-56-48.

Zborovskaya Irina Alexandrovna - doctor of medicine, head of the Research

Institute for clinical and experimental rheumatology, work tel.: (8442) 35-56-48.

47


1208 Комяков

UDC 616.613-003.7-08

© B.K. Komyakov, A.N. Akimov, N.S. Tagirov, I.B. Lazarenko, N.K.

Gadzhiev, 2010

Komyakov B.K.3, Akimov A.N.1, Tagirov N.S.2, Lazarenko I.B.1, Gadzhiev N.K.4

Combined coral calculi treatment // Preventive and clinical medicine. – 2010. - № 1

(34). – Р.65-69.1Saint Elizabeth Hospital, Russia, 195257, Saint-Petersburg, Vavilov str., 14,

Tel.: 8(812) 555-32-32, е-mail: www.elizahosp.ru2Educational state establishment of high professional education «St.

Petersburg State Pediatric Medical Academy» (ESEHPE). Russia, 194100, Saint-

Petersburg, Litovskaya str., 2. Tel.: 8(812) 245-06-46, е-mail [email protected]. Petersburg State Medical Academy named after I. I. Mechnikov (SPSMA).

Russia, 195067, Saint-Petersburg, Piskarevskiy pr. 47. Tel.: 8(812) 534-24-23. E-

mail: [email protected] Medical Academy (MMA). Russia, 194044, Saint-Petersburg,

Lebedeva str., 6. Tel.: (812) 274-9177, е-mail: [email protected]

S u m m a r y : This article is devoted to modern methods of therapy in

treatment of staghorn calculi. It is generally known that staghorn calculi are the most

difficult form of kidney stone disease. According to data provided by the Ministry of

Healthcare for the last four years illness rate has grown from 405,2 till 535,8 per

100 000 thousand people. The main objective of our research was to explore

effectiveness of examination and treatment of patient wit staghorn calculi with

maximal removing of calculi and minimal painfulness while applying modern

visualization and treatment methods. This aim was achieved owing to advanced pre-

surgical, examination, relevant antimicrobial therapy with due account for individual

peculiarities of patient. Grounding on obtained information it may be concluded, that

48


http://www.elizahosp.ru/

at the present time DLT is one of the most effective and safe methods of staghorn

calculi treatment.

K e y w o r d s : kidney stone disease; staghorn calculi; maximal removing

of calculi; extracorporeal shockwave lithotripsy.

R e f e r e n c e s

1. Абоян И.А. Роль дистанционной литотрипсии в лечении

коралловидного нефролитиаза / И.А. Абоян, С.В. Павлов, В.Э. Абоян,

А.В. Волдохин // Материалы Пленума правления Российского общества

урологов (Сочи, 28-29 апреля 2003). - М., 2003. – С. 34.

2. Александров В.П. Перкутанная нефролитолапаксия и её сочетание с

последующей ДЛТ / В.П. Александров, А.Б. Мелконян, О.Л. Тиктинский,

В.А. Семёнов // Материалы Пленума правления Российского общества

урологов (Сочи, 28-29 апреля 2003). - М., 2003. - С. 367.

3. Аляев Ю.Г. Малоинвазивная чрескожная хирургия почек и верхних

мочевых путей / Ю.Г. Аляев, Н.А. Григорьев // Врачебное сословии. – 2006. -

№5-6. - С. 8-14.

4. Дзеранов Н.К. Дистанционная литотрипсия в комплексном лечении

коралловидного нефролитиаза единственной почки / Н.К. Дзеранов,

В.И. Борисик, Э.К. Яненко, С.А. Москаленко // Материалы Пленума правления

Всероссийского общества урологов. – 1998. - С. 291-292.

5. Дзеранов Н.К. Лечение мочекаменной болезни – комплексная

медицинская проблема / Н.К. Дзеранов, Д.А. Бешлиев // Урология. – 2003. –

Приложение: Сonsilium–medicum. – С.18–22.

6. Лопаткин Н.А. Коралловидный нефролитиаз / Н.А. Лопаткин,

Э.К. Яненко // Урология и нефрология. – 1994. - №1. - С. 5-8.

7. Лопаткин Н.А. Дистанционная ударноволновая литотрипсия в лечении

камней при аномалиях почек и верхних мочевых путей / Н.А. Лопаткин,

Н.К. Дзеранов, Д.А. Бешлиев, С.А. Москаленко // Урология и нефрология. –

1999. - №1. - С. 12-16

49

8. Soygur Т. Effect of potassium citrate therapy on stonerecurrence and

residual fragments after Shockwave lithotripsy in lower caliceal calciumoxalate

urolithiasis: a randomized controlled trial / Т. Soygur, A. Akbay, S. Kupeli // J.

Endourol. – 2002. – Vol. 16(3). – Р. 149-152.

9. Tiselius H.-G. Guidelines on urolithiasis / H.-G. Tiselius, D. Ackermann, P.

Alken // Eur. Assoc. Urol. – 2002. – Vol. 1. – P. 45-58.

10. Trinchieri A. Increase in the Prevalence of Symptomatic Upper Urinary

tract Stones during the Last Ten Years / A. Trinchieri, F. Coppi, E. Montanari, A. Del

Nero // Eur. Urol. – 2000. – Vol. 37. – P. 23-25.


Komyakov Boris Kirillovich - doctor of medicine, professor, head of Saint-

Petersburg urologic associacion, chief of department of urology of State Medical

Academy named after I.I. Mechnikov. Work tel.: 8(812) 510-35-24.

Akimov Alecsandr Nicolayevich - candidate of medical sciences, assistant of

department of urology of State Medical Academy named after I.I. Mechnikov, chief

of urology department of Saint Elizabeth Hospital. Work tel.: 8(812) 555-05-89, е-

mail: [email protected]

Tagirov Nair Sabirovich - candidate of medical sciences, urologist, associate

professor of the department of Pediatric Medical Academy. Work tel.: 8(812) 555-32-

32, е-mail: [email protected]

Lazarenko Igor Borisovich - urologist of urology department of Saint Elizabeth

Hospital. Work tel.: 8(812) 555-32-32, е-mail: [email protected]

Gadjiev Nariman Kazihanovich - resident in urology of Military Medical

Academy. Work tel.: 8(812) 326-35-47


1316 Суслина

UDC 616.12-089:615.27:616.831

50



© Z.A. Suslina, L.A. Bokeriya, M.A. Piradov, A.I. Malashenkov,

N.A. Akhmadzhonuva, P.A. Fedin, Yu.V. Rodionova, O.Yu. Rebrova,

M.V. Krotenkova, A.V. Lagutin, A.S. Klochkov, 2010

Suslina Z.A., Bokeriya L.A., Piradov M.A., Malashenkov A.I., Akhmadzhonuva

N.A., Fedin P.A., Rodionova Yu.V., Rebrova O.Yu., Krotenkova M.V., Lagutin A.V.,

Klochkov A.S. Cytoflavin as a preventive means for brain lesions in cardiac surgery//

Preventive and clinical medicine. – 2010. - № 1 (34). – Р.69-74.1Scientific Center of Neurology of the Russian Academy of Medical Sciences,

125367, Moscow, Volokolamsk highway, 80.2A.N. Bakulev Scientific Center for Cardiovascular Surgery of the Russian

Academy of Medical Sciences, 121552, Moscow, Rublevsky highway, 135, tel.:8

(495) 414-75-90

S u m m a r y : Acute stroke is one of the most important complications of

coronary artery bypass grafting surgery (CABG) and valve replacement in the selling

of assisted circulation. Therefore ihe cerebral proteclion becomes llic crucial pan of

preoperative care. VJe performed prospective randomized conirolled trial to estimate

the efficacy of cytoflavin in 103 patients with ischemic heart disease (ICD) and

acquired valve disease who undergone CABG and valve replacement surgery. The

patients were divided into 4 groups. Group 1 (main) consisted of 32 patients with

ICD (mean age 55.717.9 years) who underwent CABG and received 20 ml of

cytoflavin i.v. in 3 consecutive days before and 3 days after surgery. Group 2

(control) included 40 patients with ICD (mean age 48.2± 12.6 years) and CABG

without cytoflavin. Thirteen patients with valve disease (mean age 53.1±8.4 years)

were randomized in Group 3 (main); they underwent valve replacemeni and were

treated with cytoflavin using the same regimen (20 ml i.v. in 3 days before and 3 days

after surgery). Group 4 (control) was comprised of 18 patients with valve disease

(mean age 48.2± 12.0 years) and surgery without cerebral protection with cytoflavin.

One month after the intervention sig nificant improvement (p<0.05) was observed in

Group I vs. Group 2 in the dynamic modality of cognitive performance, recent

memory and long-term memory, and clear trend to improvement in the same

51

variables in Group 3 vs. Group 4. Moreover, in Group 2 (CABG without treatment)

significant deterioration was observed in long-term memory (p=0.028), along with

the distinct trend towards worsening in Group 4 in recent and long-term memory. As

an effective antioxidanl. cytoflavin renders reliable ncuroproiectivc effect in patients

who underwent CABG in the selling of assisted circulation and improves cognitive

functioning and emolional well-being, Cytoflavin ameliorates absolute characteristics

of long-term and recent memory in patients after valve replacement surgery.

Cytoflavin improves absolute parameters of cognitive evoked potentials (P300)

decreasing the latency and increasing the amplitude in patients after CABG and valve

replacemeni. Cylollavin is recommended for use in patients with ICD and acquired

valve disease who underweni CABG and valve replacemeni in he setting of assisted

circulation.

K e y w o r d s : neuroprotection; aorta-coronary bypass surgery; Cytoflavin.

R e f e r e n c e s

1. Бузиашвили Ю.И. Влияние искусственного кровообращения на

состояние когнитивных функций у больных ишемической болезнью сердца /

Ю.И. Бузиашвили, С.Г. Амбатьелло // Журнал неврологии и психиатрии. –

2005. - № 1. - . 30-35.

2. Бокерия Л.А. Методы оценки неврологических исходов в

кардиохирургии / Л.А. Бокерия, Е.З. Голухова, А.Г. Полунина // Грудная и

сердечно-сосудистая хирургия. – 2005. - № 1. – С. 40-45.

3. Глозман Ж.М. Количественная оценка данных нейропсихологического

обследования / Ж.М. Глозман. - М.: Центр лечебной педагогики, 1999. - С. 26-

29.

4. Гнездицкий В.В. Вызванные потенциалы мозга в клинической

практике / В.В. Гнездицкий. – Таганрог: ТГРУ, 1997. – 252 с.

5. Ивницкий Ю.Ю. Янтарная кислота в системе средств метаболичесокй

коррекции функционального состояния резистентности организма /

Ю.Ю. Ивницкий, А.И. Головко, Г.А. Сафронов. - СПб.: Лань, 1998. – 35 с.

52

6. Коберская Н.Н. Когнитивный потенциал Р300 / Н.Н. Коберская //

Неврологический журнал. – 2003. - № 6. – С 34-37.

7. Корсакова Н.К. Клиническая нейропсихология / Н.К. Корсакова,

Л.И. Московичюте. - М.: Изд. Центр «Академия», 2003. - С. 74-80.

8. Лурия А.Р. Основы нейропсихологии / А.Р. Лурия. - М., 1973. – 151 с.

9. Сейидов В.Г. Сравнение результатов коронарного шунтирования в

течение первого года после операции и консервативного лечения / В.Г. Сейидов

// Клиническая фармакология и терапия. – 2006. - № 4 (15). - С. 78-81.

10. Томас Ф. Неврологическая оценка и лечение больных после операции

на сердце / Ф. Томас // Бюллетень НЦССХ им. Бакулева РАМН. – 2002. - Т3. -

С. 4.

11. Шабалова А.В. Неврологические осложнение аортокоронарного

шунтирования: виды, патогенез, профилактика / А.В. Шабалова,

Д.Н. Джибладзе, Э.Н. Казаков // Атмосфера. Нервные болезни. – 2004. - № 4. -

С. 9-13.

12. Шабалова А.В. Комплексная оценка особенностей церебральной

гемодинамики, неврологического статуса и когнитивных функций у больных с

атеросклеротическим поражением коронарных артерий, требующим

хирургической коррекции. Дисс. … канд. Мед наук. – М., 2004. – 20 с.

13. Шевченко Ю.Л. Кардиохирургическая агрессия и головной мозг /

Ю.Л. Шевченко, А.А. Михайленко, А.Н. Кузнецов, А.А. Ерофеев. – СПб.:

Наука, 1997. – 85 с.

14. Ancelin M.L. Exposure to anaesthetic agents, cognitive functioning, and

depressive symptomalogy in the elerly / M.L. Ancelin, G. De Roquefeuil //

Br.J.Psychiatry. – 2001. - Vol. 178. - P. 102-111.

15. Guy M. Stroke and encephalohfthy after cardiac surgery an update /

M. Guy, M.D. Mckhann, R.N. Grega // Stroke. – 2006. - Vol. 37. - Р. 562-571.

53

16. Madl C. Cognitive brain function in non-demented patients with low-grade

and high-grade carotid artery stenosis / C. Madl, G. Grimm, L. Kramer // Eur. J. Clin.

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resuscitation / C. Madl, G. Grimm, L. Kramer // Lancet. – 1993. - Vol. 341. – Р. 855-

858.

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Thorac. Surg. – 1993. - Vol. 56. - Р. 91-100.

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surgery: a prospective study / J.M. Murkin, J.S. Martzke, A.M. Bucham // Anesth.

Analg. – 1992. - Vol. 74. - Р. 8215.

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undergoing coronary artery bypass graft surgery / M.F. Newman, R. Wolman,

M. Kanchuger // Circulation. – 1996. - Vol. 94. – Suppl. II. – Р. 74-80.

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G.W. Roach, M. Kanchuger, C.M. Mangano // N. Engl. J. Med. – 1996. - Vol. 335. –

Р. 1857-1863.

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aging population / Per M.D. Thorvaldsen, Michael Davidsen Stable // Stoke. – 1999.

- Vol. 30. – Р. 2529-2534.

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Thome Surg. – 1995. - Vol. 59. – Р. 1336-1339.

24. Wolman R.L. Cerebral injury after cardiac surgery: identification of a group

at extraordinary risk. Multicenter Study of Perioperative Ischemia Research Group

(McSPI) and the Ischemia Research Education Foundation (IREF) Investigators /

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522.

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older adults: a randomized trial / P. Williams-Russo, N.E. Sharrock, S. Mattis //

JAMA. – 1995. - Vol. 274. - P. 44-50.

54


Suslina Zinaida Aleksandrovna – Academician of the Russian Academy of

Medical Science, Professor, M.D., director of RAS establishment Scientific Center

for Neurology of the Russian Academy of Medical Sciences. 125367, Moscow,

Volokolamsk highway, 80. Tel.: 8(495) 490-20-02, fax: 8(495) 490-25-06. E-mail:

[email protected].

Bokeriya Leo Antonovich – Academician of the Russian Academy of Medical

Sciences, Professor, chief cardiologist of the Ministry of Health of the Russian

Federation, director of A.N.Bakulev Scientific Centre for Cardiovascular Surgery of

the Russian Academy of Medical Sciences, President of the Association of

Cardiovascular Surgeons of Russia.

Piradov Michael Aleksandrovich – M.D., Professor, deputy director on

scientific work of RAMS Scientific Center for Neurology of the Russian Academy

of Medical Sciences, head of the department of Resuscitation. 125367, Moscow,

Volokolamsk highway, 80.

Malashenkov Anatoly Ivanovich – Corresponding Member of RAN, Professor

of Medical Sciences, deputy director on research work of A.N.Bakulev Scientific

Centre for Cardiovascular Surgery of the Russian Academy of Medical Sciences,

director of the institute of Coronary and Vascular Surgery.


1230 Косинец

UDC 616.381-002.3-092.9:615.27©V.A. Kosinets, 2010

Kosinets V.A. Efficacy of metabolic drug "Cytoflavin" use in experimental

widespread purulent peritonitis // Preventive and clinical medicine. – 2010. - № 1

(34). – Р.74-78.

«Vitebsk state awards of Friendship of the people medical university».

Byelorussia, Vitebsk, Frunze str., 27. Тel.: 8(0212) 37-09-37. E-mail:

[email protected]

55



S u m m a r y : One of key factors of endogenous intoxication development at

a widespread purulent peritonitis is a misbalanced free-radical oxidation.

Hyperactivation of peroxide lipid’s oxidation and decrease of antioxidant activity

underlie infringement cell’s mitochondria function. The carried out researches have

shown that metabolic remedy «Cytoflavin» possesses expressed antioxidant

properties, provides effective and fast restoration of peroxide lipid’s oxidation and

antioxidant activity balance, increases speed of free radicals elimination.

K e y w o r d s : widespread purulent peritonitis; cytoflavin; amber acid;

intestine; peroxide lipid’s oxidation; antioxidant activity; mitochondria.

R e f e r e n c e s

1. Андреева Л.И. Модификация метода определения перекисей липидов в

тесте с тиобарбитуровой кислотой / Л.И. Андреева, Л.А. Кожемякин, А.А.

Кишкун // Лаб. дело. – 1988. – № 11. – С. 41-43.

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Афанасьев. – Санкт-Петербург. – 2005. – 44 c.

3. Гаин Ю.М. Синдром энтеральной недостаточности при перитоните:

теоретические и практические аспекты, диагностика и лечение / Ю.М. Гаин,

С.И. Леонович, С.А. Алексеев. – Молодечно, 2001. – 265 с.

4. Илюкевич Г.В. Особенности нарушений метаболизма липидов и

возможность их коррекции у больных с распространенным перитонитом / Г.В.

Илюкевич, И.И. Канус, Г.Я. Хулуп // Вестник интенсивной терапии. – 2002. –

№3. – С. 83-87.

5. Инструкция по медицинскому применению препарата Цитофлавин,

Р№003135/1 от 21.01.2005

6. Косинец В.А. Функциональное состояние митохондрий мышечного

слоя тонкой кишки при экспериментальном распространенном гнойном

перитоните / В.А. Косинец // Вестник Витебского государственного

медицинского университета. – 2007 – № 4. – С. 31-38.

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Стручков. – Витебск, 2004. – 510 с.

56

8. Кузьмина Е.И. Применение индуцированной хемилюминесценции для

оценки свободно-радикальных реакций в биологических субстратах / Е.И.

Кузьмина, А.С. Нелюбин, М.К. Щенникова // МежВУЗовский сборник.

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1997. – 208 с.


Kosinets Vladimir Alexandrovich – candidate of medical sciences, The

assistant of the Department of hospital surgery of Vitebsk state medical university.

Work tel.: 8(0212) 22-60-72, mob.: +375-296-24-20-76. E-mail:

[email protected]


1314 Романцов, ГорячеваUDC 615.27-053.2/.6

© M.G. Romantsov, L.G. Goryacheva, A.L. Kovalenko, 2010

Romantsov M.G., Goryacheva L.G., Kovalenko A.L. Cycloferon for treatment

and prevention of children diseases // Preventive and clinical medicine. – 2010. - № 1

(34). – Р.78-90.1State Educational Establishment of Higher Professional Training «Mechnikov


and Social Development of the Russian Federation», 195067, St.-Petersburg, K-67,

Piskarevsky prospect, 47, tel. (812) 543-96-09, fax: (812) 740-15-24, e-mail:

[email protected]; www.mechnik.spb.ru2Research Institute for сhildren infections Научно-исследовательский

институт детских инфекций, Russia, 197022, Saint-Petersburg, Prof. Popov str., 9.

57




Теl.: (812) 234-60-04, 234-18-62. Fax: (812) 234-52-83. E-mail:

[email protected] 3Scientific-Technological Pharmaceutical Firm “POLYSAN”, Russia, 191119,

Saint-Petersburg, Ligovsky prospect, 112, tel.: 8(812)110-82-25,112-13-79, е-mail:

[email protected], STPF “POLYSAN” www.polysan.ru

S u m m a r y . The article presents authors’ own material and literary data on

cycloferon pharmacotherapeutic efficiency. Cycloferon belongs to a group of

interferon inducers, immunomodulators. The effect of the preparation at various

children socially-significant diseases is described. These include ARVI, bronchial

asthma, allergic conditions accompanied by the disorder of antiinfectious protection,

mycoplasmic infection, broncho-pulmonary complications in ARVI with low

intensity of free-radical oxidation. Suppression of autoimmune processes, which are

the cause of postvaccinal complications in often ill children, is shown with the use of

cycloferon on the background of planned vaccination. Results of cycloferon use in

case of gastrointestinal tract diseases, intestinal infections both of viral and bacterial

genesis are described. Cycloferon use for intestinal dysbiosis correction is suggested,

microflora restoration to normal level is noted in 95 % of children. Preparation use

for surgical pathology, particularly in appendicular peritonitis, with the aim of

decreasing postoperative complications, and also for the correction of immune

disorders in chronic viral hepatitis C and B in children treated with the combined

therapy is described. Cycloferon safety and efficiency is proved by the postmarketing

randomized studies of its efficiency.

K e y w o r d s : Cycloferon; treatment; disease prevention; often ill

children.

R e f e r e n c e s

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гепатита В на фоне лямблиоза у детей в условиях Дагестана //Автореф. дисс.

…..к.м.н.-СПб.-2009.-21с.

58

http://www.polysan.ru/


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Челябинск.-2006.-21с..

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Терапевтическая эффективность индукторов синтеза интерферона при

бронхиальной астме у детей, страдающих частыми острыми респираторными

вирусными инфекциями // Материалы IV конгресса педиатров-инфекционистов

России «Актуальные вопросы инфекционной патологии у детей (диагностика и

лечение)», Москва, 2005 г. - С. 28.

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врачей.-Санкт-Петербург.-2007.-26с.

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59

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23. Москалева Е.В., Смирнова С.В.,Петрова А.Г. Циклоферон при ВИЧ-

инфекции у детей с перинатальным инфицированием.-Санкт-Петербург.-2008.-

24с.

24. Назарочкина О.В.,Харченко Г.А. Вирусные менингиты у детей.

Коррекция циклофероном нарушений в системе иммунитета //Информационно-

методическое письмо для врачей. -Санкт-Петербург.-2008.-22с.

25. Ошева Т.М. Воспалительные заболевания верхних отделов

пищеварительного тракта у детей // Информационно-методическое письмо для

врачей.-Санкт-Петербург.-2007.-24с.

26. Применение циклоферона для экстренной профилактики ОРВИ в

организованных детских и подростковых коллективах. Методические

рекомендации №23 Департамента здравоохранения Москвы под редакцией

Е.А.Дегтяревой.-М.,-2008.-24с.

27. Противовирусная терапия инфекционных болезней детского

возраста //Сборник научных статей.-М.,-2006.-79с.

28. Применение циклоферона в педиатрической практике //Сборник

научных статей.-Санкт-Петербург.-2005.-96с.

29. Романцов М.Г., Ботвиньева. Практика педиатра. Циклоферон.-Санкт-

Петербург.-2005.-14с.

30. Рациональная фармакотерапия часто болеющих детей /Романцов М.Г.,

Ботвиньева В.В.,Шульдякова О.Г.-Санкт-Петербург.-2006.-115с.

31. Романцов М.Г., Ершов Ф.И. Часто болеющие дети. Современная

фармакотерапия. Москва.-2009.-349с.

61

32. Романцов М.Г. Сологуб Т.В. Экстренная неспецифическая

профилактика и лечение гриппа и ОРВИ. Лекция для врачей.-Санкт-

Петербург.-2008.—42с..

33. Романцов М.Г., Горячева Л.Г., Коваленко А.Л. Противовирусные и

иммунотропные препараты в детской практике.-Санкт-Петербург.-120с.

34.Романцов М.Г.,Зарубаев В.В.,Коваленко А.Л., Сологуб Т.В. Грипп А/H1N1-

типичная эмерджентная инфекця. Вопросы терапии и экстренной

профилактики /\Вестник Санкт-Петербургской государственной медицинской

академии им.И.И.Мечникова.-2009.-№2.-С.168-172.

35. Селькова Е.П. Профилактика респираторных заболеваний в период

эпидемического подъема.-Москва.-2003.-30с.

36. Серозные менингиты у детей //Сборник статей.-Санкт-Петербург.-

2007.-30с.

37. Тихомирова О.В. Ротавирусная инфекция.Особенности клинического

течения и тактика терапии //Учебное пособие.-Санкт-Петербург.-2005.-80с.

38. Часто болеющие дети: современная фармакотерапия // М.Г.Романцов,

Ф.И.Ершов.- Издательская группа «ГЭОТАР-Медиа», Москва.-2006.-192с.

39. Эффективность циклоферона при проведении экстренной

профилактики ОРВИ в организованных коллективах. Методические

рекомендации для врачей./Шульдяков А.А., Петленко С.В., Романцов М.Г.,

Сологуб Т.В.).-Санкт-Петербург.-2007.-16 с.


Romantsov Mikhail Grigorievich – Doctor of Medicine, Professor of the

department of Infectious Diseases of SEEHPT «Saint-Petersburg State Medical

Academy named after I.I.Mechnikov of Roszdrav». Тel.: 8-812-710-82-25. E-mail:

[email protected]

Kovalenko Alexsandr Leonidovith - Scientific-Technological Pharmaceutical

Firm “POLYSAN”, Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.:

8(812)110-82-25,112-13-79, е-mail: [email protected], STPF “POLYSAN”

www.polysan.ru

62



1291 Сайганов

UDC 616.12-008.46-08

© S.A. Sayganov, O.G. Khurtsilava, 2010

Sayganov S.A., Khurtsilava O.G. Acute cardiac insufficiency treatment in

myocardium infarction of the right ventricle // Preventive and clinical medicine. –

2010. - № 1 (34). – Р.90-95.

State Educational Establishment for Additional Professional Training «Saint-

Petersburg Medical Academy for Post-Diploma Training of the Federal Agency for

Public Health and Social Development of the Russian Federation». Russia, 191015,

St.-Petersburg, Kirochnaya str., 41. Тel.: 8 (812) 272-52-06, fax: 8 (812) 273-00-39.

Е-mail: [email protected]

S u m m a r y : Correction of hemodynamic disorders in acute right ventricle

insufficiency (ARVI) due to myocardium infarction (MI) of the right ventricle

usually consists of treatment by inotropic maintaining drugs and preload increase on

the right ventricle (RV) for increased output into pulmonary artery. However at

present, there are no precise recommendations on fluid introduction in ARVI

treatment.

To determine optimum criteria of infusion therapy 42 patients with MI of the

lower localization and MIRV were included into the study. MIRV was complicated

with ARVI. All patients were prescribed dobutamin and reopolyglukin (300 ml/hour)

was introduced intravenously under pulmonary artery pressure (PAP) control,

jamming pulmonary artery pressure (JPAP), central venous pressure (CVP).

Perfusion cardiac index (CI) was determined by thermodelution method.

Echocardiographic examination was performed before treatment and at optimum

JPAP values.

It was found that in ARVI patients at initially low APP and JPAP (16.2±0.21

and 7.0±0.18 mm hg) CVP is increased (11.2±0.25 mm hg). On the background of

63


reopolyglukin introduction CI increased from 1.82±0.03 to 2.51±0.04 l/min/m2 (p

<0.001) at JPAP of 18 mm hg. At the same time no marked CVP increase was

observed. Further fluid introduction with JPAP up to 20 mm hg did not result in

further CI increase and was followed by substantial CVP increase (from 13.7±0.23 to

16.2±0.24 mm hg; p <0.001). On the background of treatment LV size increased

(from 52.3±0.57 to 54.4±0.60 mm increased; p <0.05) and fraction output also

increased (from 37.5±0.87 to 41.9±0.99 %; p <0.05) in the absence of significant

dynamics on the right cardiac chambers.

The obtained data show expediency of preload increase on the right ventricle

for ARVI treatment. Fluid should be introduced together with inotropic maintaining

drug therapy. Target JPAP in IRVI treatment is 18 mm hg at which FV volume LV

increases thus showing the improvement of its filling. Fluid infusion is not expedient

at CVP increase higher than that of JPAP. In this case final increase of diastolic

pressure in LV is leveled by higher rates of RV filling pressure and no increase LV

filling is observed.

K e y w o r d s : right ventricle myocardium infarction; acute right ventricle

insufficiency; treatment; right ventricle preload increase.

R e f e r e n c e s

1. Ганелина И.Е. Атеросклероз коронарных артерий и ишемическая

болезни сердца / И.Е. Ганелина. – СПб.: «Наука», 2004. – 260 c.

2. Денисенко Б.А. Инфаркт миокарда правого и левого желудочков /

Б.А. Денисенко, Г.А. Гольдберг, Ю.П. Дробышев. – Новосибирск, 1987. – 225 c.

3. Диагностика и лечение инфаркта правого желудочка / Г.А. Газарян,

И.В. Захаров, Д.А. Чепкий, Н.М. Бикбова // Клиническая медицина. – 2007. – Т.

85. – № 6. – С. 67-70.

4. Показатели центральной гемодинамики у больных инфарктом

миокарда обеих желудочков / А.В. Соплевенко [и др.] // Южно-Российский

медицинский журнал. – 2000. – № 5-6. – С. 34-37.

5. Сыркин А.Л. Инфаркт миокарда. – 3-е изд., перераб. и доп. /

А.Л. Сыркин. - М.: Мед. информ. агентство, 2003. – 466 с.

64

6. Comparative effects of volume loading, dobutamine, and nitroprusside in

patients with predominant right ventricular infarction./ L.J. Dell'Italia, M.R. Starling,

R. Blumhardt [et al.] // Circulation. – 1985. – Vol. 72. – P. 1327-1335.

7. Determinants of hemodynamic compromise with severe right ventricular

infarction / J.A. Goldstein, B. Barzilai, T.L. Rosamond [et al.] // Circulation. – 1990.

– Vol. 82. – P. 359-368.

8. Gandy W.E. Recognition and treatment of right ventricular myocardial

infarction / W.E. Gandy // EMS Magazine. – 2008. – Vol. 37. – № 3. – P. 69-73.

9. Goldstein J.A. Pathophysiology and management of right heart ischemia /

J.A. Goldstein // J Am Coll Cardiol. – 2002. – Vol. 40. – P. 841-853.

10. Goldstein J.A. Right versus left ventricular shock. A tale of two ventricles /

J.A. Goldstein // J Am Coll Cardiol. – 2003. – Vol. 41. – P. 1280-1282.

11. Hemodynamics of volume loading compared with dobutamine in severe

right ventricular infarction / M. Ferrario, A. Poli, M. Previtali, L. Lanzarini // Am J

Cardiol. – 1994. – Vol. 74. – № 4. – P. 329-333.

12. Initial report of percutaneous right ventricular assist for right ventricular

shock secondary to right ventricular infarction. / G.M. Giesler, J.S. Gomez, G. Letsou

[et al.] // Catheter Cardiovasc Interv. – 2006. – Vol. 68. – № 2. – P. 263-266.

13. Piazza G. The acutely decompensated right ventricle: pathways for

diagnosis and management / G. Piazza, S.Z. Goldhaber // Chest. – 2005. – Vol. 28. –

№ 3. – P. 1836 – 1852.

14. Romand J.A. Acute right ventricular failure, pathophysiology and treatment

/ J.A. Romand, F.A. Donald, P.M. Suter // Monaldi Arch Chest Dis. – 1995. – Vol.

50. – № 2. – P. 129-133.

15. Siniorakis E.E. Volume loading in predominant right ventricular infarction:

bedside haemodynamics using rapid response thermistors / E.E. Siniorakis,

N.I. Nikolaou, C.D. Sarantopoulos // European Heart Journal. – 1994. – Vol. 15. – №

10. – P. 1340-1347.

16. Wellens H.J.J. Right ventricular infarction / H.J.J. Wellens // N Engl J

Med. – 1993. – Vol. 328. – № 8. – P. 1036-1038.

65


Sayganov Sergey Anatolievich – Assistant Professor of M.S.Kushakovsky

Cardiology department of the St.-Petersburg Medical Academy for Post-Diploma

Training of the Federal Agency on Public Health Services and Social Development.

Теl.: 8(921) 948-40-93. E-mail: [email protected];

[email protected]

Hurtsilava Otari Givievich – M.D., Professor, Rector of the St.-Petersburg

Medical Academy for Post-Diploma Training of the Federal Agency on Public Health

Services and Social Development.


1293 Шустер

UDC 616.62-003.7-089:[616.69:616.153.49]-085.357

© P.I. Shuster, O.N. Tselebrovskaya, F.A. Sagidullin, 2010

Shuster P.I.1, Tselebrovskaya O.N.2, Sagidullin F.A.2 Hypogonadism androgen

therapy efficacy and safety in patients with hyperuricemy and radically eliminated

urolithiasis // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.95-99.1 State Educational Establishment of Higher Professional Training «Omsk State

Medical academy of the Federal Agency for Public Health and Social Development

of the Russian Federation», 644099, Omsk, Lenina str., 12, tel.: 8(381) 223-32-89.2 State Educational Institution of the Higher Professional Education «Bashkir

State Medical University», 450000, Ufa, Lenina str., 3, tеl/fax: 8(347) 272-37-51, е-


S u m m a r y : As a result of research it has been revealed that androgenic

therapy of elimination hypogonadism, improves not only the general condition and

the sexual status of patients, but also reduces Lesch-Nyhan syndrome that is

preventive maintenance urate urolithiasis.

K е y w o r d s : hypogonadism; urolithiasis.

R e f e r e n c e s

66



1. Аляев Ю.Г. Метафилактика мочекаменной болезни / Ю.Г. Аляев,

А.В. Амосов, В.С. Саенко. - М., 2007. - 350 с.

2. Лопаткин Н.А. Пятнадцатилетний опыт применения ДЛТ в лечении

МКБ / Н.А. Лопаткин, И.К. Дзеранов // Пленум правления Российского

общества урологов. Материалы. - М., 2003. - С.5.

3. Назаров Т.Н. Метаболические нарушения при андрогеном дефиците у

мужчин, страдающих уролитиазом / Т.Н. Назаров, В.В. Михайличенко,

В.П. Александров // Материалы Российско-Кубинского андрологического

Форума. 1-11 апреля 2008. -М., 2008. - С. 103.

4. Пытель Ю.А. Уратный нефролитиаз / Ю.А. Пытель, И.И. Золотарев. –

М., 1995. - 176 с.

5. Реброва О.Ю. Статистический анализ медицинских данных.

Применение пакета прикладных программ STATISTICA / О.Ю. Реброва. - М.,

2002. - 312 с.


Shuster P.I. - Ph.D. (Medicine), senior lecturer of faculty surgery with an

urology course, Omsk State Medical Academy, tel. 8(913)972-02-72, е-mail: ship-

[email protected]

Tselebrovskaya O.N. - competitor of a scientific degree of faculty of biological

and bioorganic chemistry, Bashkir State Medical University, tel. 8(898)995-50-81, е-


Sagidullin F.A. - Ph.D. (Medicine), senior lecturer of faculty of biological and

bioorganic chemistry, Bashkir State Medical University, tel. 8(347)273-61-71, е-



1296 Ишинова

UDC 616.89-008.441:612.843.3

© V.A. Ishinova, 2010

67





DYNAMIC OF TACTILE SENSITIYITY IN PATIENTS WITH

PSYCHOGENIC PAIN DURING THE PSYCHICAL RELAXATION

V. A. Ishinova

The Institution of special psychology and pedagogy, Saint-Petersburg

Ishinova V.A. Dynamics of tactile sensitivity in patients with psychogenic pain

in the course of mental relaxation // Preventive and clinical medicine. – 2010. - № 1

(34). – Р.99-102.

Non-state educational institution of higher vocational level «The Institution of

special psychology and pedagogy» (NOY ISPiP), 194356, Saint-Petersburg, B.

Ozernaia, 92 А, phone : 8-(812) 596-24-42, E-mail: [email protected]

S u m m a r y : In the present work there was conducted the research of

dynamic of thresholds of tactile sensation during the psychical relaxation with

psychogenic pain as exemplified by patients with anxiety phobic diseases versus

patients, affected somatogenic pain, and healthy people. Assessment of patients’s

psychophysiological state of both groups was being carried out in the beginning and

at the end of psychological correction course. There was used the empatho-technique

as method of psychical relaxation.

K e y w o r d s : anxiety phobic diseases, psychogenic pain, somatogenic

pain, thresholds of tactile sensation, focused ultrasound, psychical relaxation,

empatho-technique.

The pain is one of the most popular and relevant complaint in clinic practice of the

therapeutist. The problem of her control is important practical task. In order to choose

adequate methods of therapy it is necessary to comprehend particularities of

pathogenesis of pains disorders, of which general groups are somatogenic,

psychogenic and neurogenic pain [5, 6, 1, 9]. Psychogenic pain is of the most interest,

of which progression mechanism supposes the leading significance of negative

emotional state, which initiate the pain in the absence of serious somatic diseases [4,

7, 1]. Therefore, determination of the leading pathogenetic mechanism, that is at the

68

root of occurrence of pain syndrome, contributes the improvement of effectiveness of

rendering assistance. In view of this the present work describes studying of changes

of tactile sensitivity in patients with psychogenic pain as exemplified by anxiety

phobic diseases during the psychological correction versus the patients with

somatogenic pain. We have assumed that threshold of tactile sensation depend on

sustained by the time of research feeling of internal and external irritants, that can

change under the influence of stress factors. It was also expected that instability of

excitative process, that is linked with psychoemotional stress, must be in the picture

of alteration of wavering of threshold of tactile sensation during the psychological

correction with psychic relaxation’s application.

T h e p u r p o s e o f s t u d y. Study of the interrelationship between the intensity

of painful, the intensity of negative emotional state and tactile sensitivity of patients

with anxiety phobic diseases.

Materials and methods of research.

Research was carried out for 42 patients with anxiety phobic diseases (11 men and 31

woman ) with cephalagia, abdominal, vertebra pains, which had psychogenic nature

(Group 1). Patients with anxiety phobic diseases had complaints on high anxiety,

obsession fears, anxiety, sleep disturbance.

As a control group there was researched:

- 30 persons (22 women and 8 men) with somatogenic pain (group 2). They had

complaints about cephalgia (craniocerebral trauma in parity), abdominal (there was

educed cholelithiasis) and vertebragenous pain (there was found thoracic and cervical

spine osteochondrosis). Patients was examined in the clinic № 45 of SPb, where were

made relevant diagnoses.

- 54 healthy subjects (40 women and 14 men), who didn’t have neurosal and somatic

complaints and presented the group «conditionally healthy persons».

An average age of researched persons was 34, 07±1,41.

Psychological testing was conducted at the beginning and end of the course of

psychological correction. There were used the anxiety scale of Spielberg-Chanin and

69

scales of enquirer of psychopathologic symptomatic SCL-90-R [10] for assessment of

emotional state. Pain intensity was identified by the scale «pain» from an enquirer of

life quality MOS SF-36 [8]. Therewith the factor was the better, the higher. All

enquirers are validated.

There was used the plant consisted of the generator and focalizing ultrasonic

source (frequency of focused ultrasound 1,7MHz) for tactile sensitivity research [4].

Thresholds of tactile sensitivity ware determined on the skin of terminal phalange of

right arm forefinger. For that end the finger was placed on the room-temperature

water surface in such way that the medium of phalange of forefinger was in the center

of focalizing source. Impulse intensity was taken as the threshold of tactile sensation,

that conveyed a tactile sensation not less than 2 times during 3 presentation. The

tactile sensitivity was researched with persons of all groups: 1. healthy people –

before and after one psychical relaxation session; 2. patients with ТФР and persons

with somatogenic pain – before and after every psychical relaxation session during

the whole course of psychological correction. There were taken measures for analysis

that was got before and after the first empatho-techniques session and also before

and after lat session.

There was used psychical relaxation method (empatho-techniques) for

management of psychogenic pain and leveling of negative emotional state, that

presented in detail in the previous work [2, 11].

Statistical processing of the data obtained was carried out using the STATISTICA

v 5.5 computer program.

R e s u l t s a n d d i s c u s s i o n

At the beginning of the course of psychological correction patients with APD had

the pronounced pain (56,86±4,12), whose factor was credibly (p < 0.01) lower than in

the group of healthy subjects (77.57±2,56) and credibly (p < 0.05) higher than in the

group of subjects with somatogenic pain (41,3±3,59). Pain senses of the patients with

APD were accompanied by excessive values of the questionnaire SCL-90-R on all

scales and high level of ЛТ (Table 1). In most cases all found factors were credibly (р

< 0,01) higher that for the patients with somatogenic pain (Table 1).

70

http://multitran.ru/c/m.exe?t=708545_1_2



Empatho-techniques use permitted to improve the emotional state of the patients of

both groups, that conduced to decrease of the intensity of the pain. Thus at the end of

psychological correction course there was the credible (p<0,001) decrease of pain

intensity (78,21±2,93) in the group of patients with the APD, whose factor didn’t

have credible difference from healthy subjects factor versus patients of group 2

(50,27±2,62). Patients with somatogenic pain had continued to feel pain against the

end of course, that can be linked with the particularities of mechanisms of

psychogenic and somatogenic pain formation.

Table 1 Average values of checklist factors SCL-90-R, trait (ЛТ) and reactive (РТ) anxiety in the group of patients with the anxiety phobic disorders (group 1), patients with somatogenic pain (group 2) before and at the end of psychological correction course and group of healthy subjects.

Scales

Group 1before

psychological

correction

Group 2before

psychological

correction

р<(р-level)

Group 1after

psychological

correction

Group 2after

psychological

correction

р<(р-

level)

healthy subjects

COM 1,34±0,14 0,98±0,12 -(0,084) 0,57±0,06 0,61±0,08 -

(0,664) 0,39± 0,05

O-C 1,24±0,11 0,79±0,11 0,01(0,006) 0,62±0,07 0,45±0,05 -

(0,143)0,40±0,04

INТ 1,07±0,12 0,83±0,11 -(0,186) 0,47±0,05 0,61±0,08 -

(0,531)0,44±0,04

DEP 1,40±0,12 0,78±0,10 -(0,218) 0,56±0,07 0,57±0,07 -

(0,799)0,29± 0,03

ANX 1,54±0,13 0,84±0,10 0,001(0,001) 0,56±0,07 0,53±0,08 -

(0,743)0,24±0,03

HOS 1,02±0,13 0,79±0,13 -(0,224) 0,41±0,08 0,48±0,07 -

(0,176)0,32±0,04

PHOB0,90±0,12 0,37±0,05 0,001

(0,001) 0,28±0,06 0,24±0,04 -(0,956)

0,09±0,01

РТ 38,5±1,60 32,87±1,86

0,05(0,013) 28,35±1,44 27,03±1,4

3-

(0,708)24,31±0,89

ЛТ52,86±1,85 46,9±1,56 0,05

(0,026) 41,85±1,34 40,93±1,51

-(0,677)

36,72±0,67

СOM – Comatization; O-C – Obsessive-Compulsive disorders; INТ – Interpersonal Sensitivity; DEP – Depression; ANX – Anxiety; HOS – Hostility; PHOB – Phobic Anxiety.

Against the end of the psychological correction course there was noted credible

(р < 0,01) decrease of all researched factors in the group of patients with

71

psychogenic and somatogenic pain. However their average values at the group

of patients with APD and subjects with somatogenic pain didn’t have credible

differences but were credibly different from healthy subjects factors (Table 1).

The research of thresholds of tactile sensitivity indicates that their average values

didn’t have credible differences in all researched groups before and after the

empatho-technic session in the beginning and at the end of the psychological

correction course (Diagram 1).

0

2

4

6

8

10

12

1 2 а 2b 3а 3 b

dB

Diagram 1. Average values of absolute thresholds tactile sensitivity before( ) and after ( ) empatho-techniques session for healthy subjects (1), for patients

with anxiety phobic diseases before and after first session of psychological correction (2 a), before and after last session of psychological correction (2 b); for patients with somatogenic pain before and after first session (3 а), before and after

last session of psychological correction (3 b) . dB – measurement units of the thresholds of tactile sensitivity in dB for patients; . – before empatho-techniques

session; - after empatho-techniques session.

However by comparison with group of healthy people there were revealed

credibly (p < 0,05) higher values in the subjects with psychogenic and somatogenic

pain in the beginning of the psychological correction course, and in subjects only

with somatogenic pain at the end of the course, that can be determined by differences

in mechanisms of psychogenic and somatogenic pain formation (Diagram 1). For

research of the intensity of the thresholds of tactile sensation changes we were

defining the difference between factors of absolute thresholds of tactile sensation got

72

before the empatho-technic session and after that for every studied subject, and

specified that difference as delta (│∆│, dB).

∆1 complied with 2,56±0,33 dB in patients with APD before psychological

correction that was credibly higher than in subjects with somatogenic pain (1,37±0,18

dB) and healthy people (1,23±0,12 dB). ∆2 complied with 1,57±0,21 dB in patients

with APD at the end of the course that was credibly higher than in subjects with

somatogenic pain (0,90±0,15 dB) but came around to delta value of healthy people

(Diagram 2).

0

0,5

1

1,5

2

2,5

3

3,5

1 2а 2б 3а 3б

дБ

Diagram 2. Delta average values in the healthy subjects (1), in patients with anxiety phobic diseases before psychological correction (2а), after psychological correction (2b), in patients with somatogenic pain before psychological correction (3a), after psychological correction (3b). dB - measurement units of the thresholds of tactile sensation in dB.

Conclusion. Therefore, according to received results, there was found that pain of

high intensity in the patients of both groups was accompanied by negative emotional

states and expressed increase of tactile sensation delta before psychological

correction. Negative emotional states leveling contributed to psychogenic pain

management and credible decrease of tactile sensation delta at the end of the course

that can argue about recovery of regulatory processes and correlation of the central

and peripheral tactile sensation links and reflect the optimization of the CNS

functional status indirectly. Thus, according to earlier researches there was noted the

reduction of the neurodynamic processes fluctuation in terms of brain bioelectrical

73

activity (BEA) and the reduction of excitative processes expression according to the

data from driving rhythm of the photostimulation in the patients with APD [2].

Correlation relationships analysis showed that the pain of subjects with APD was

interrelated with the scale «somatization» factor as corporal equivalent of anxiety,

and tactile sensation delta – with the aggression factor. The pain factor of subjects

with somatogenic pain was correlated with interindividual sensation factor, the pain

factor of healthy subjects – with depression.

C o n c l u s i o n s

1. The psychogenic pain of the patients with APD is accompanied by higher

values of aggression, anxiety, depression factors and expressed tactile

sensation delta.

2. The psychorelaxation methodology contributes to credible reduction of

negative emotional states intensity, credible reduction of tactile sensation delta

and psychogenic pain management.

3. The somatogenic pain is credibly more expressed in the beginning and at the

end of psychological correction course that psychogenic, and tactile sensation

delta is credibly higher in subjects with APD rather than in subjects with

somatogenic pain.

R e f e r e n c e s

1. Adashinskaia G.A, Enicopov S.N., Mayzerov E.E. Pain and color //Psychology

journal. - 2005. - Т. 26. - № 3. - P. 74 – 80.

2. Ishinova V.A.1, Svyatogor I.A.2 The pain’s color reflection of patients with

anxiety phobic disorders // Herald of the Mechnikov Saint-Petersburg State

Medical Academy. – 2009. – № 2 . – Р.198 – 202.

3. Ishinova V.A., Ananjev V.A., Cirulnicov E.M., Timofeeva L.L. Tactility

sensitivity and psychotherapeutic treatment //Journal «Sensory systems». 2007.

21. - № 2. P. 125 – 129.

4. Сlinical psychiatry / Ed. T.V.. Dmitrieva. - Moscow: GEОТАR MЕDICAL,

1998. – 505 p.

74


5. Коrolenko C.P., Pavlenko С.С. Оbjectivation of pain and her rating //Pain and

her treatment. - 1995. - № 2. - С.7-9.

6. Kukushkin M.L., Hitrov N.L. Total pathology of the pain - Moscow:Меdicine.

2004. - 144 с.

7. Marilov V.V. Private psychopathology: Textbook for students of higher

educational establishment. - M.: «Аcademy», 2004. - 400 p.

8. Novik A.A., Ionova T.I. Handbook on life quality research in Medicine.

St.Petersburg: Neva, 2002. – 320 p.

9. Psychosomatic illness in doctor’s practical: handbook for doctors / Ed. V.I.

Simanenkov. – SPb: SpecLit, 2008. – 335 p.

10. Tarabrina N.B. Psychology practicum of post-traumatic stress disorders. -

SPb.: Piter, 2001. - 272 p.

11. Ishinova V. A., Svyatogor I. A., Reznikova T. N. Features of colour reflection

in psychogenic pain in patients with somatoform disorders during

psychotherapeutic treatment // The Spanish Journal of Psychology. – 2009. -

Volume 12 (2). - P. 715-724.


Ishinova Vera Alexandrovna – candidate of psychology science, senior lecturer

of the Institute of special pedagogy and psychology, work phone: (8-812) 752-67-14,

home telephone: (8-812) 534-2018, e-mail: [email protected] signature


1302 Галеев

UDC 616.37-002-07

© Sh.I. Galeev, M.E. Topuzov, M.A. Rubtsov, 2010

Galeev Sh.I.1, Topuzov M.E.1, Rubtsov M.A.2 Prognosis of severe acute

pancreatitis // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.102-105.1State Educational Establishment of Higher Professional Training «Mechnikov


and Social Development of the Russian Federation», 195067, St.- Petersburg, K-67,

75


mechnik @ gmail . com ; mechnik @ westcall . net ; www.mechnik.spb.ru2 State administration on Public Health Services “Clinical Hospital of Prelate

Luka (Prof. of Medicine Voyno-Yasenetsky)", St.-Petersburg, Chugunnaya str., 46,

tel.: 8(812) 328-99-58, fax: 8(812) 540-12-38.

S u m m a r y : The clinically based Atlanta Classification was formulated in

1992, but in recent years it has been increasingly criticized. No formal evaluation of

the use of the Atlanta definitions of predicted severe pancreatitis in the literature has

ever been performed. We have performed such analysis and concluded: complex

evaluation of different laboratory and instrumental data is more reliable instrument

than conventional APACHE II ≥ 8.

K e y w o r d s : acute pancreatitis; severe pancreatitis; Atlanta criteria of

severity.

R e f e r e n c e s

1. Савельев В.С. Деструктивный панкреатит: алгоритм диагностики и

лечения (проект, составленный по материалам IX Всероссийского съезда

хирургов, 20-22 сентября, Волгоград) / В.С. Савельев, М.И. Филимонов,

Б.Р. Гельфанд // Consilium medicum. – 2000. – №2. – 5 с.

2. Данилов М.В. Дискуссионные вопросы хирургии острого

деструктивного панкреатита / М.В. Данилов // Анналы хирургической

гепатологии. – 2001. – Т.6. – С. 125-130.

3. Balthazar E.J. Acute pancreatitis: Assessment of severity with clinical and

CT evaluation / E.J. Balthazar // Radiol. – 2002. – Vol. 223. – P. 603-613.

4. Beger H.G., Rau B.M. Severe acute pancreatitis: clinical course and

management / H.G. Beger, B.M. Rau // World J. Gastroenterol. – 2007. – Vol. 13. –

P. 5043-5051.

5. McKay C.J. Natural history of organ failure in acute pancreatitis /

C.J. McKay, A. Buter // Pancreatol. – 2003. – Vol. 3. – P. 111-114.

76



6. Neoptolemos J.P. Early prediction of severity in acute pancreatitis by urinary

trypsinogen activation peptide: a multicentre study / J.P. Neoptolemos, J.M. Mayer,

E.A. Kemppainen // Lancet. – 2000. – Vol. 355. – P. 1955-1960.

7. Rau B.M. Outcome determinants in acute pancreatitis / B.M. Rau // Am. J.

Surg. – 2007. – Suppl. to October. – P. S39-S44.

8. Uhl W. IAP guidelines for the surgical management of acute pancreatitis /

W. Uhl, A. Warshaw, C. Imrie // Pancreatol. – 2002. – Vol. 2. – P. 565-573.


Galeyev Shamil Ibragimovich - Assistant, the department of Surgical Diseases

with the course of Children Surgery of I.I.Mechnikov St.-Petersburg State Medical

Academy, tel.: 8(921) 915-70-10, e-mail: [email protected]

Topuzov Marlen Eskenderovich – M.D., department of Urology of

I.I.Mechnikov St.-Petersburg State Medical Academy, tel.: 8(921) 915-70-10, e-mail:

[email protected]

Rubtsov Michail Aleksandrovich – head of the Surgical department of the

clinical hospital of Prelate Luka (Prof. of Medicine Voyno-Yasenetsky), tel.: 8(812)

328-99-58, e-mail: [email protected]


1212 Теплов UDC 612.741.001.6

© A.Yu.Teplov, S.N.Grishin, A.M.Farkhutdinov, 2010

Possible mechanisms of change contraction of function of isolated striated

muscles of the mouse at allergic reorganization of the organism

A.Y. Teplov, S.N. Grishin, A.M. Farkhutdinov

Kazan State Medical University, Kazan, Russia

Teplov A.Yu., Grishin S.N., Farkhutdinov A.M. Possible mechanisms of

contractile function change in isolated murine striated muscles at allergic body

change // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.105-110.

77

State Educational Establishment for Higher Professional Training «Kazan State

Medical University of the Federal Agency for Public Health and Social Development

of the Russian Federation». Russia, 420012, Kazan, Butlerova str., 49, tel.:

8(843)236-05-63, e-mail: [email protected] or [email protected]

S u m m a r y : The study observes contraction function of striated mouse

muscles at protein sensibility – m. diaphragm, m. extensor digitorum longus, m.

soleus. It is shown that protein sensibility changes contractile force of all researched

muscles. Thece changes differ for muscles with different fenotipe.

K e y w o r d s : skeletal muscle, contraction characteristics, m. extensor

digitorum longus, m. soleus, m. diaphragma, non-quantal secretion, ovalbumin

sensabilization.

Well-known, that airway muscles functional state and, primarily, diaphragm, is essentially

changed in asthma, the disease of allergic origin. We have previously studied the influence of

ovalbumin sensabilization on contraction function of guinea-pig isolated diaphragm strip. To be

more concrete, its ability to change its contractile functions by increase of force and shortening

velocity on carbacholine (CCh) in terms of ovalbumin sensabilization was shown. To explain this

fact, changes of electrogenic features as well as histochemical profile of muscle fibers were

proposed. Furthermore, as the contraction of isolated muscle was initiated by agonist we can

suggest the participation of surface membrane cholinergic receptors activation mechanisms in the

change of muscle fibers functional features at ovalbumin sensabilization. Diaphragm is a mixed

muscle; it consists of “fast” and “slow” muscle fibers (MF). Recently we showed that ovalbumin

sensabilization changes contraction functions of isolated – “fast” and “slow” – shank mouse skeletal

muscles. Dynamics of contraction function of studied skeletal muscles shows remarkable

differences. For clarity, cholinemediated processes of excitement of postsynaptic membrane play an

important role in the mechanisms of contraction force change. The ability of mouse diaphragm to

change its functions in terms of allergic restructure and its possible mechanisms remain to be

determined.

T h e p u r p o s e of the present study is to reveal cholinemediated mechanisms in

pathogenesis influence of ovalbumin sensabilization on contraction functions of mouse isolated

muscles: “mixed” – diaphragm strip (m. Diaphragma); “fast” - m. extensor digitorum longus (m.

EDL) and "slow" – m. Soleus.

78



The complex researches were performed to investigate this problem. Two experimental

models which are characteristic for cholinemediated processes of excitement of isolated mouse

striated muscles were used to study the effects of ovalbumin sensabilization on: 1) the rates of

contraction muscles response, caused by agonist CCh and 2) the level of non-quantal secretion of

acetylcholine (ACh) in a zone of a trailer plate.

M a t e r i a l s a n d m e t h o d s . Experiments were conducted on both sexes mice

weighing 17-22 g. Animals were twice ovalbumin sensabilitized (OS) with gel hydrate aluminum (2

mkg of dry gel substance + 150 mkg ОА in 0,5 ml of a physiological solution) parenteral. The

second injection was made in 14 days after the first one. Animals were got into experiment on a

pique of sensabilization – 7-10 days after the second sensabilization injections. Mechanomiographic

researches were conducted on a preparation of an isolated muscle in terms of an isometry. Skeletal

muscle was stretched during 20 minutes with force of 500 mg at a constant perfusion by a solution

Krebs type to maintain isometry and temperature at 20-21 C. Contraction was recorded by the

photoelectric converter. Agonist CCh was investigated at submaximal concentration: for m. EDL –

7х10-4М, a m. Diaphragm strip - 2х10-4М, m. Soleus – 5х10-4М. Contraction function was analyzed

according muscles contraction parameters on CCh. Muscle contraction force (Poc) and speed (Vос)

were estimated. Contraction force developed by isolated muscle was related to its mass (m) (Poc* -

numerically equal volume of a muscular preparation) to get objective information at the force

characteristics analysis.

To study a condition of muscle fiber postsynaptic membrane in the zone of a trailer plate non

quantum secretion of Ach was studied. It was measured by glass microelectrodes (with the

resistance of 8-12 MΩ, filled with 2,5 M KCl). To determine its size armin action

acetylcholinesteraze, then on a muscle was eliminated during 8-12 minutes application m-

cholinergic receptors blockader d-tubocurarine (d-TC) (10-5М). The rates difference of membrane

potential before and after application d-TC corresponds to the rate of not quantum secretion of ACh

(Н-effect).

The results were analyzed by comparing data from experiments on intact muscles (control)

and sensibility animals (experiment). Statistical analyzes was performed by Student's t test.

R e s u l t s . Biometric parameters of the studied skeletal muscles are represented in Table

1. Contraction parameters of isolated m. EDL, a m. Diaphragm strips and mouse m. Soleus on CCh

at submaximal concentration in the control and at ovalbumin sensabilization are represented in

Tables 2, 3 and 4.

Table 1 Biometric parameters of “fast”, “slow” and “mixed” mouse muscle preparation in control and at ovalbumin sensabilization (experiment)

m.EDL m.Soleus Диафрагма

79

Lengthmm

Massmg

Lengthmm

Massmg

Lengthmm

Massmg

Control 8,21±0,14 7,57±0,21 7,20±0,10

6,53±0,18 6,50±0,27 7,00±0,39

Experiment 9,00±0,25 10,08±0,40

7,85±0,15

6,31±0,24 6,14±0,26 7,79±0,53

For "fast" muscle it is shown that CCh at submaximal concentration caused contraction of

with force of 76,59±6,51 mg and speed of 14,3±1,6 mg/s. m. EDL contraction force decreased,

speed practically did not change at ovalbumin sensabilization (Table 2).

Table 2Parameters of isolated m. extensor digitorum longus contraction (X±Sx) on CCh (7х10-4

М) in control and at ovalbumin sensabilization (experiment)

Experiment termsContraction parameters

Рос, mg

Рос*mg/mm3

Vос,mg/s

Control n=26

76,59±6,51

9,94±0,39

14,26±1,55

Experiment n=5

61,92±12,42

5,65±0,82

***

13,62±4,09

Note: * - р<0,05; ** - р<0,01 ; *** - р<0,001

Study of non quantum secretion of ACh in "fast" mouse muscle fiber has shown the following

data. Initial rate of membrane potential in the terms of rest was 72,3±0,6 мВ (n=150). But at

presence of d-TC it increased up to 77,4±1,6 мВ (n=150). Thus, the Н-effect in the terms of control

makes 5,1±0,4 мВ (n=150). In the terms of ovalbumin sensabilization initial rate of membrane

potential of the rest was 73,9±0,5 мВ (n=150). At presence of d-TC it increased up to 79,7±1,7 мВ

(n=150). It means that the Н-effect value has increased, making in the described terms of

experiment 5,8±0,5 мВ (n=150, р <0,05).

In the "mixed" on intact muscle mouse CCh at submaximal concentration caused contraction

with force of 342,8+-18,54 mg and speed 31,0+-1,7 mg/s. Ovalbumin sensabilization resulted in

force increase and speed increase - 32,08+-0,89 mg/s of slow muscle contraction (Table 3).

Table 3 Parameters of isolated strip of diaphragmic muscle contraction (X±Sx) on CCh (2х10-4

М) in control and at ovalbumin sensabilization (experiment)Experiment terms Contraction parameters

Рос, mg

Рос*mg/mm3

Vос,mg/s

Control n=10

342,8±18,54

49,20±1,75

31,0±1,7

80

Experiment n=7

448,29±19,16

**

58,66±3,97

**

32,08±0,89

Note: * - р<0,05; ** - р<0,01 ; *** - р<0,001

Study of non quantum secretion of ACh of "mixed" muscle has shown: initial rate of

membrane potential of the rest was 70,7±1,9 мВ (n=150). At presence of d-TC it increased up to

75,9±0,7 мВ (n=150). Thus, Н-effect in the control makes 5,2±0,4 мВ (n=150). Initial rate of

membrane potential of the rest was 70,0±1,5 мВ (n=150). At ovalbumin sensabilization at the

presence of d-TC it increased up to 74,4±0,6 мВ (n=150). Tit means that the Н-effect value

decreased, making in the described terms of experiment 4,4±0,5 мВ (n=150, р <0,05).

At "slow" intact mouse muscle CCh at submaximal concentration caused contraction with the

force of 237,77±20,61 mg and speed of 13,1±1,0 mg/s. Ovalbumin sensabilization resulted in

force and speed increase (Table 4).

Table 4 Parameters of isolated mouse m. soleus contraction (X±Sx) on CCh (5х10-4 М) in

control and at ovalbumin sensabilization (experiment)Experiment terms Contraction parameters

Рос, mg

Рос*mg/mm3

Vос,mg/s

Controln=28

237,77±20,61

35,61±1,67

13,10±0,99

Experiment n=11

353,25±23,11

54,18±4,99

***

16,62±1,50

Note: * - р<0,05; ** - р<0,01 ; *** - р<0,001

Study of non quantum secretion of ACh has shown: initial rate of membrane potential of rest

was 70,9±1,7 мВ (n=160). But at presence of d-TC it increased up to 75,9±1,3 мВ (n=160). Thus,

Н-effect in the control makes 5,0±0,7 мВ (n=160). Initial rate of membrane potential of rest making

69,4±0,9 мВ (n=150) at ovalbumin sensabilization at presence of d-TC increased up to 72,5±1,0 мВ

(n=150). It means that the Н-effect value decreased making in the described conditions of

experiment 3,1±0,6 мВ (n=150, р <0,05).

D i s c u s s i o n . Results of studies indicate that ovalbumin sensabilization

changes contraction function of diaphragm strip as well as isolated shank mouse

skeletal muscles (Table 2-4). To clarify, nature of these changes is essentially

different for “fast” and “slow” muscles. Basic differences of morph-functional status

of studied objects and its change mechanisms in the process of allergic restructure of

an organism can explain this fact.

81

Presumably, the fiber structure defines the differences in contractile force of

observed muscles of nonsensibility animals on CCh. Soleus mouse muscle contains

50-60% of “slow” filaments, m.EDL – 97-100% of “fast” filaments. Mouse

diaphragm, that takes media position, contains 88.6% of fast myosin. Presumably,

force differences result from different level of muscle fibers sensibility to CCh that

suggests direct dependence on the area of synapse. It is known that the size of a

trailer plate of “slow” muscle fiber of soleus mouse muscle is 3 lengths than that of

“fast” muscle fiber (m.EDL). Considering similarity of biometric parameters (length

and mass, Table 1) of observed muscles, more sensibility to cholinomediate, caused

by greater number of cholinergic receptors in the area of synapse, must result in more

contractile force of m. soleus and diaphragm on CCh.

Changes of diaphragmatic muscle functional features in terms of ovalbumin

sensabilization suggest that changes in muscle fiber during allergic restructure of an

organism are complex. Changes occurring in muscle fiber during sensabilization may

affect surface membrane, electromechanical connected mechanisms or contractile

protein system. The absence of corresponding changes of shortening velocity on sub

maximal concentration of agonist of all the muscles doesn’t suggest

electromechanical connected system changes. However, various of force change

vector of “fast” muscle from the one side and “mixed” and “slow” muscles from the

other side indicate principle difference of change mechanisms of muscles` functional

features at ovalbumin sensabilization.

While contractile force (Poc*) of “fast” muscle decreases (Table 2), contractile

force of “slow” and “mixed” muscles increases (Table 3, 4). This dynamics confirms

the fact that differences of “fast” muscle from the one side and “mixed” and “slow”

muscles form the other side at ovalbumin sensabilization affect, primarily,

cholinemediate processes of excitement of muscle fibers manifold effect.

Evidence that ovalbumin sensabilization is able to affect the mechanisms of

excitement of postsynaptic membrane of different muscles in different way comes

from comparing muscle contractile force dynamics on CCh with level change of non-

quantal secretion in the zone of a trailer plate. Force change vector of observed

82

muscles at ovalbumin sensabilization correlates with level change of non-quantal

secretion of Ach in the zone of a trailer plate (H-effect) (Figure 1A, 1B)

Figure 1. Ovalbumin sensabilization effect on: A) contraction force of isolated mouse

m.EDL caused by CCh (7х10-4 М). Б) H-effect value

83

We may conclude that the decrease of contractile force of “fast” muscle on

CCh results from the decrease of postsynapse sensibility to cholinomediate. The

evidence of this fact comes from the increasing H-effect (Fig. 1A, Б). Increase of

non-quantal secretion of Ach in the zone of synapse contributes intensification of

desensabilization mechanisms of cholinergic receptors of postsynaptic membrane.

Correspondingly, we observe reverse picture about “mixed” and “slow” muscles.

Increase of contractile force on CCh results from increase of postsynapse sensibility

to CCh. Decreasing H-effect reflects this process (Fig. 2A, Б, 3А, Б).

Fig. 2 Ovalbumin sensabilization effect on: A) contraction force of isolated mouse

m.soleus caused by CCh (5х10-4 М). Б) H-effect value

84

Fig. 3 Ovalbumin sensabilization effect on: A) contraction force of isolated mouse

diaphragm strip caused by CCh (2х10-4 М). Б) H-effect value

C o n c l u s i o n . Thus, allergic restructure of an organism causes changes

of contraction function of isolated mouse skeletal muscles. Contractile force (Poc*)

on CCh of “fast” muscle decreases and, correspondingly, of “mixed” and “slow”

muscles increases. This rate change occurs from the following. Decrease of

contractile force of “fast” muscle (m.EDL) results from decrease of postsynaptic

membrane sensibility to CCh that is caused by increasing of non-quantal secretion of

Ach in the zone of a trailer plate. “Mixed” and “slow” muscles show reverse

dynamics of contractile force as well as of non-quantal secretion of ACh. Increase of

contractile force of these muscles on CCh at ovalbumin sensabilization results from

increasing postsynaptic membrane sensibility to cholinomediate that is caused by

decrease of non-quantal secretion of Ach in the zone of a trailer plate. Different

changes of contraction function of skeletal muscles at ovalbumin sensabilization are

caused, primarily, by dynamics of cholinomediated processes of membrane

excitement of muscle fibers.

85

R e f e r e n c e s

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Teplov Alexander Yurievich – candidate of biology sciences, assistant

professor of the Department of Pathophysiology of Kazan State Medical University,

work tel.: 8 (843) 236-05-63, home tel.: 8 (843) 234-59-50, mobile phone 8-904-665-

78-30, e-mail: [email protected]

Grishin Sergey Nikolaevich - candidate of biology sciences, assistant professor

of the Department of Normal Physiology of Kazan State Medical University. E -mail:

[email protected]

Farkhutdinov Albert Mansurovich – post-graduate student of the Department

of Pathophysiology of Kazan State Medical University, work tel.: 8 (843) 236-05-63,

e-mail: [email protected]


1225 ЕрмоловUDC 616.36-036.12:616-073.7

© Ermolov S.Yu., Ermolova T.V., Dobkes A.L., 2010

Ermolov S.Yu. 1 1, Ermolova T.V. 1 1, Dobkes A.L. 2 2 Role of hemodynamic factors

in evaluation of plasmaphoresis efficacy in patients with chronic liver diseases //


OO «DIAS». Russia, Saint-Petersburg, Partizan German str., 22 (А), tel.: (812)

756-95-64

S u m m a r y : Plazmapheresis (PPh) is widely used in the treatment of

chronic liver diseases (CLD). However, during the PPh it is nesessary to predict the

risk of complications risk. The aim of our study was to offer the method of prognosis

of plasmapheresis complications at the chronic liver diseases patients. The basis of

this method – polihepatography (PHG). PHG is method of estimation liver

87




hemodynamics, based on analysis of some rheogramms (waves of blood liver

microcirculation) portohepatic area and waves of the central pulse.

K e y w o r d s : Plazmapheresis (PPh); сhronic liver diseases (CLD);

рolihepatography (PHG); liver hemodynamics.

R e f e r e n c e s

1 . Ермолов С.Ю. Роль немедикаментозных методов в комплексной терапии

больных хроническими заболеваниями печени: Автореф. дис. … канд.мед.наук. -

СПб., 1997 - 18 с.

2. Ермолов С.Ю., Шабров А.В., Добкес А.Л. Полигепатография.

Гемодинамика. + Гепатит // Спб.: ЭЛБИ-СПб, 2007. - 324 с.

3. Зиновьева Е.Н. Клиническая оценка плазмафереза и криоафереза в

комплексном лечении больных хроническими заболеваниями печени: Автореф.

дис. … канд. мед. наук. - СПб., 1999. - 26 с.

4. Курдыбайло Ф.В., Колмаков В.Н., Радченко В.Г., Нечаев В.В. Влияние

гемосорбции на клиническое течение хронических заболеваний печени //

Врачебное дело. - 1988. - №7. - С 60-63.

5. Радченко В.Г., Шабров А.В., Зиновьева Е.Н. Основы клинической

гепатологии. - СПб.: Диалект, 2005. - 864 с.

6. Радченко В.Г., Шабров А В., Нечаев В.В. Хронические заболевания печени.

СПб.: Лань, 2000. – 190 с.

7. Лопухин Ю.М. Гемосорбция. (2 издание, переработанное и дополненное).-

М.: Медицина, 1985. - 288 с.

8. Литвинов А.С. Клиническая оценка гемосорбции в лечении хронических

гепатитов и циррозов печени: Автореф. дис. … канд. мед. наук. - Л., 1986. - 21 с.

9. Шабров А.В., Радченко В.Г.,. Ермоловым С.Ю и др. Эфферентная терапия в

комплексном лечении больных хроническими заболеваниями печени // СПб.:

Ладога, 2000. 53 с.

10. Lenz K., Buder R., Fritsch N., Gegenhuber A., et al. The Artificial Liver – Liver

Support Systems // European Surgery. - 2008. - Vol. 34. - Issue 3. – P. 194-198.


88

Ermolov S.- PhD, Head of St.-Petersburg Mechnicov’s Hospital. Tel. mob.:

+79219328364, Tel.: +78125430342. Е-mail: [email protected].

Ermolova T. – PhD, Associate Professor of St.-Petersburg State Mechnicov’s

Medical Academy, Internal Diseases Department, Tel.mob.: +79219134201, Tel.:

+78125454747. Е-mail: [email protected].

Dobkes A.- General Chief of public noncommercial regional organization

“DIAS”. Tel.: +78124318882, Tel.mob.: +79119106568, e-mail: [email protected].

Accepted а 20.10.2009 г.

1319 Гриневич

UDC 616.36-004-07

© V.B. Grinevich, E.N. Lapteva, D.V. Egorov, Y.A. Kravchuk, 2010

Grinevich V.B.1, Lapteva E.N.2, Egorov D.V. 1, Kravchuk Y.A. 1 Estimation of

the index of body´s mass by the method of two-frequency bioelectrical impedance

analisis at the patients with discompensative cirrhosis of the liver // Preventive and

clinical medicine. – 2010. - № 1 (34). – Р.115-118.1Federal State Educational Establishment «Medical Military Academy name

S.M. Kirova». Russia, 194044, St.-Petersburg, Botcina str., 19/21, tel.: 8(812) 271-

87-28, fax: 8(812) 271-87-28.2State Educational Establishment for Additional Professional Training «Saint-

Petersburg Medical Academy for Post-Diploma Training of the Federal Agency for

Public Health and Social Development of the Russian Federation». Russia, 191015,

Kirochnaya str., 41, tel.: 272-52-06, fax: 273-00-39, e-mail: [email protected]

S u m m a r y : On the basis of worked out biophysical body’s model, by the

method of bioelectrical impedance analysis, it was determined at 129 patients with

decompensated liver’s cirrhosis the quantity of aesthetic liquid in the abdominal

cavity. Taking that into account, the body’s mass and the index of body’s mass were

calculated. It was determined that 55,8% examined patient had got hypotrophy. The

degree of hypotrophy was associated with the length of alcohol’s abuse, with

89




accumulation of radiopharmpreparation in the spleen, with dimensions of the liver

and the spleen, with circumference and coliperometric facts.

K e y w o r d s : cirrhosis of the liver; ascites; index mass body;

bioelectrical impedance analysis.

R e f e r e n c e s

1. Буклис Э.Р. Коррекция трофологического статуса у больных циррозом

печени // Рос. журн. гастроэнтерол., гепатол., колопроктол.: Мат. VIII Рос.

конференции «Гепатология сегодня». – 2003. – Т.17, №5. – С.53-57.

2. Жолинский А.В. Нутритивная поддержка в коррекции компонентного

состава тела при перетоните // дисс. канд. мед. наук. – М., 2007. – 135 с.

3. Иванов Г.Г., Сыркин А.Л., Дворников В.Е. и др. Мультичастотный

сегментарный биоимпедансный анализ в оценке изменений объема водных

секторов организма // Анест. и реан.-1999.- №2.-С.41-47.

4. Ивашкин В.Т. Рациональная фармакотерапия в гепатологии / В.Т.

Ивашкин, М.В. Маевская, А.О. Буеверов и др. – М.: Литтерра, 2009. − 296 с.

5. Ивашкин В.Т. Гастроэнтерология: национальное руководство / В.Т.

Ивашкин. − М.: «ГЭОТАР-Медиа», 2006. − 704 с.

6. Костюченко А.Л., Железный О.К., Шведов А.Г. Энтеральное

искусственное питание в клинической медицине. – Петрозаводск: «ИнтелТек»,

2001. – 208 с.

7. Мартинчик А.Н., Маев И.В., Петухов А.Б. Питание человека (основы

нутрициологии). - М., 2002. – 572 с.

8. Подымова С. Д. Болезни печени. 3-е издание. – М.: Медицина, 1998. –

544 с.

9. Хазанов А. И. Эволюция этиологических факторов циррозов печени по

результатам 60-летних наблюдений за больными в крупном многопрофильном

стационаре / А. И. Хазанов // Рос. журн. гастроэнтерологии, гепатологии,

колопроктологии. – 2006. – Т.11, №5. – С. 56−61.

10. Хорошилов И.Е. Руководство по парентеральному и энтеральному

питанию / Под ред. И.Е. Хорошилова. – СПб.: «Нордмед-Издат», 2000. – 376 с.

90

http://www.ozon.ru/context/detail/id/1655414/

11. Шерлок Ш., Дули Дж. Заболевания печени и желчных путей: практ.

руководство: пер. с англ. / Ш. Шерлок, Дж. Дули. – М.: Гэотар Медицина, 1999.

– 864 с.

12. Bosetti C. Worldwide mortality from cirrhosis: An update to 2002 / Bosetti

C., Levi F., Lucchini F. et al. // Hepatol. – 2007. – Vol. 46. – P. 827−839.

13. Cable E., de Leon R., Planas R. Reliability of bioelectric impedance

analysis as a method of nutritional monitoring in cirrhosis with ascites //

Gastroenterol Hepatol. - 1995. - Vol.18, №7. - P.359–65.

14. Chumlea W.C. Anthropometric and body composition assessment in

dialysis patients // Semin Dial. – 2004, Nov-Dec. – Vol.17(6). – P.466-70.

15. Ganion V., Rhodes M., Stadler R.W. Intrathoracic impedance to monitor

heart failure status: a comparison of two methods in a chronic heart failure dog

model. Congest Heart Fail. 2005 Jul-Aug;11(4): 177-81, 211. Nutr. Metab.

Cardiovasc. Dis. 2005 Jun;15(3): S.198-203.

16. Lindley E., Devine Y., Hall L., Cullen M., Cuthbert S., Woodrow G., Lopot

F. A ward-based procedure for assessment of fluid status in peritoneal dialysis

patients using bioimpedance spectroscopy. Perit Dial Int. 2005 Feb; 25 Suppl 3:

S.46-8.

17. Mendez-Sanchez N. Worldwide mortality from cirrhosis / N. Mendez-

Sanchez, A. R. Villa, D. Zamora-Valdes et al. // Ann. Hepatol. – 2007. – Vol. 6. – P.

194–195.

18. Moore K. P. Guidelines on the management of ascites in cirrhosis / K. P.

Moore, G. P. Aithal // Gut. – 2006. − Vol. 55. – P. 1–12.

19. Morgan M.Y., Madden A.M. The assessment of body composition in

patients with cirrhosis // Eur. J. Nucl. Med. – 1996. V.23, №2. P.213-225.

20. Noskov V.B., Kotov A.N. Impedancimetry of the hydration status and body

composition of head-down tilted males. Aviakosm Ekolog Med. 2005 Jul-Aug; 39(4):

41-5.

21. Piccoli A. Whole body-single frequency bioimpedance. Contrib. Nephrol.

2005; 149: 150-61.

91

22. Zaluska W., Malecka T., Mozul S. Whole body versus segmental

bioimpedance measurements (BIS) of electrical resistance (Re) and extracellular

volume (ECV) for assessment of dry weight in end-stage renal patients treated by

hemodialysis. Przegl Lek. 2004; 61(2): 70-3.


Grinevich Vladimir Borisovich - doctor of medicine, head of the 2 department

therapy (improved doctors) MMA, mobile tel.: 8(812) 271-87-28.

Lapteva Elena Nicolaevna – doctor of medicine, consultant MAPE, work tel.:

8(812) 235-26-63, 8(812) 235-09-47.

Egorov Denis Vladimirovich – postgraduated of the 2 department therapy

(improved doctors) MMA, work tel.: 8-905-268-48-62. Е-mail: [email protected].

Kravchuk Yriy Alecseevich - candidate of medical sciences, assistant-professor

of the 2 department therapy (improved doctors) MMA, work tel.: 8(812) 271-87-28,

моб. 8-911-215-80-33. Е-mail: [email protected]

Accepted 19.10.2009г.

1331 ЧупровUDC 616.5-006.6-018

© I.N. Chuprov, 2010

Chuprov I.N. The updated complex description of the skin basal cell carcinoma

// Preventive and clinical medicine. – 2010. - № 1 (34). – Р.118-123.

Saint Petersburg Medical Academy of Postgraduate Studies, Russia, 191015,

Saint Petersburg, Kirochnaya str., 41, tel.: 8-812-303-50-00, fax: 8-812-303-50-35.

S u m m a r y : The contemporary complex characteric of the skin basal cell

carcinoma (SBCC), one of the most frequent neoplasm, is present. The clinical course

of the SBCC strongly depends on the topographic form, proliferative activity and

stromal reactions. The prognostic value of these morphological markers is discussed.

K e y w o r d s : skin; basal cell carcinoma; immunohistochemistry.

R e f e r e n c e s

92



1. Дерматоонкология / под ред. Г. А. Галил-Оглы, В. А. Молочкова, Ю. В.

Сергеева. − М. : Медицина для всех, 2005. − 872 с. – ISBN 5-93649-019-X.

2. Дубенский В.В. Современные аспекты эпидемиологии, патогенеза,

клиники и лечения базально-клеточного кожи / В. В. Дубенский, А. А.

Гармонов // Вестник дерматологии и венерологии. − 2004. − № 6. − С. 7−12.

3. Снарская Е.С. Базалиома / Е. С. Снарская, В. А. Молочков. − М. :

Медицина, 2003. − 324с.

4. Хлебникова А.Н. Клинико-морфологические и иммуногистохимические

особенности различных форм базальноклеточного рака кожи и комплексный

метод его лечения : автореф. дис. …д-ра мед. наук : 14.00.11, 14.00.15 / А. Н.

Хлебникова. – М., 2007. – 37с.

5. Angiogenesis and skin carcinomas with skull base invasion: a case-control

study / C. R. Cernea [et al.] // Head Neck. − 2004. − № 5. − P. 396 − 400 .

6. Anthouli-Anagnostopoulou F. Recurrent morphean basal cell carcinoma of

the skin. A clinico-histopathological study of 97 cases. / F. Anthouli-

Anagnostopoulou, E. Hatziolou // Adv Clin Path. − 2002. − № 1. − P. 17 − 24 .

7. Bax expression and growth behavior of basal cell carcinomas / C. M. Tilli

[et al.] // J Cutan Pathol. − 2002. − № 2. − P. 79 − 87.

8. Collins G.L. Changing demographics and pathology of nonmelanoma skin

cancer in the last 30 years / G. L. Collins, N. Nickoonahand, M. B. Morgan // Semin

Cutan Med Surg. − 2004. − № 1. − P. 80 −8 3.

9. Hendrix J.D. Jr Micronodular basal cell carcinoma. A deceptive histologic

subtype with frequent clinically undetected tumor extension / J. D. Hendrix Jr, H. L.

Parlette // Arch Dermatol. − 1996. − № 3. − P. 295−298.

10. Interaction between bcl-2 and P53 in neoplastic progression of basal cell

carcinoma of the head and neck / S. Staibano [et al.] // Anticancer Res. − 2001. − №

6A. − P. 3757 −37 64.

11. Kaur P. Basal cell carcinoma progression correlates with host immune

response and stromal alterations: a histologic analysis / P. Kaur, M. Mulvaney, J. A.

Carlson // Am J Dermatopathol. − 2006. − № 4. − P. 293 − 307.

93

javascript:AL_get(this,%20'jour',%20'Am%20J%20Dermatopathol.');

javascript:AL_get(this,%20'jour',%20'Anticancer%20Res.');

javascript:AL_get(this,%20'jour',%20'Anticancer%20Res.');

javascript:AL_get(this,%20'jour',%20'Semin%20Cutan%20Med%20Surg.');

javascript:AL_get(this,%20'jour',%20'Semin%20Cutan%20Med%20Surg.');

javascript:AL_get(this,%20'jour',%20'J%20Cutan%20Pathol.');

javascript:AL_get(this,%20'jour',%20'Adv%20Clin%20Path.');

javascript:AL_get(this,%20'jour',%20'Head%20Neck.');

12. Mast cells and cutaneous malignancies / S. Ch'ng [et al.] // Mod Pathol. −

2006. − № 1. − P. 149 −1 59.

13. The stromal reaction in basal cell carcinomas. A prerequisite for tumour

progression and treatment strategy / U. Bertheim [et al.] // Br J Plast Surg. − 2004. −

№ 5. − P. 429 −4 39 .

14. Trends in incidence of skin basal cell carcinoma. Additional evidence from

a UK primary care database study / F. Bath-Hextall [et al.] // Int J Cancer. − 2007. −

№ 9. − P. 2105 −210 8 .

С в е д е н и я о б а в т о р е :

Чупров Игорь Николаевич - к.м.н., доцент, тел.: 8-921-387-03-78, 8-904-



EPIDEMIOLOGY, DIAGNOSTICS, CLINIC AND PREVENTION OF INFECTIOUS AND PARASITIC DISEASES

1317 Зарубаев

UDC 615.281.8:616.921.5-092.4

© V.V. Zarubaev, A.L. Kovalenko, T.V. Sologub, M.G. Romantsov, A.Yu. Petrov,

2010

Zarubaev V.V. 1, Kovalenko A.L. 3, Sologub T.V. 2, Romantsov M.G. 2, Petrov

A.Yu. 3 Comparative efficacy of antiviral drugs in experimental influenza infection

caused by viruses А/Swine (Н1N1), Puerto (Н1N1), Мallard|PennsyLvania (H5 N2) //

Preventive and clinical medicine. – 2010. - № 1 (34). – Р.123-132.1Research institutes of Influenza of the Northwest District of the Russian

Academy of Medical Sciences, Russia, 199022, St.-Petersburg, Prof. Popov str.,

15/17.2Saint-Petersburg state medical academy named after I. I. Mechnicov, Saint-



94


javascript:AL_get(this,%20'jour',%20'Int%20J%20Cancer.');

javascript:AL_get(this,%20'jour',%20'Int%20J%20Cancer.');

javascript:AL_get(this,%20'jour',%20'Br%20J%20Plast%20Surg.');

javascript:AL_get(this,%20'jour',%20'Br%20J%20Plast%20Surg.');

javascript:AL_get(this,%20'jour',%20'Mod%20Pathol.');

javascript:AL_get(this,%20'jour',%20'Mod%20Pathol.');

3Scientific-Technological Pharmaceutical Firm «POLYSAN», Russia, 191119,



S u m m a r y : The article deals with biopharmaceutical studies concerning

comparative evaluation of antiviral drugs protective activity (cycloferon, remantadin,

Tamiflu). Cycloferon use in influenza experimental infection results in post-influenza

pneumonia focus limitation. This effect is noted in infection with all of the studied

influenza A viruses, irrespective of their sensitivity or resistance to the drugs of

comparison. Cycloferon protective activity ranges from 11% to 50 % depending on

the used virus dose and modeling strain, cycloferon protection index was 35-41 %.

Cycloferon was shown to be a drug influencing both natural immunodefence system

(endogenous interferon induction), and processes of proper virus morphogenesis,

reducing infection properties of the virus progeny.

K e y w o r d s : virus A influenza; treatment; natural immunodefence;

cycloferon.

R e f e r e n c e s

1. Ali A. Influenza Virus Assembly: Effect of Influenza Virus Glycoproteins on

the Membrane Association of M1 Protein / A. Ali, R.T. Avalos, E. Ponimaskin,

D.P. Nayak // J. Virol. – 2000. – Vol. 74(18). – Р. 8709–8719.

2. Bourmakina S.V. Reverse genetics studies on the filamentous morphology of

influenza A virus / S.V. Bourmakina, A. Garcia-Sastre // J. Gen. Virol. – 2003. -

Vol. 84. – Р. 517–527.

3. Bukharin O.V. Influence of cycloferon on the biological properties of

bacterial intracellular pathogens / O.V. Bukharin, D.A. Kirillov, N.V. Sheenkov,

V.A. Kirillov // Zh Mikrobiol Epidemiol Immunobiol. – 2005. - Vol. 3. – Р. 8-10.

4. Hale B.G. The multifunctional NS1 protein of influenza A viruses /

B.G. Hale, R.E. Randall, J. Ortyn, D. Jackson // Journal of General Virology. – 2008.

- Vol. 89. – Р. 2359–2376.

95

http://www.ncbi.nlm.nih.gov/pubmed/16028504



5. Nelson M.I. The origin and global emergence of adamantane resistant

A/H3N2 influenza viruses / M.I. Nelson, L. Simonsen, C. Viboud, M. Miller //

Virology. – 2009. - Vol. 388. – Р. 270–278.

6. Romantsov M.G. Cycloferon in the treatment of infectious diseases /

M.G. Romantsov, F.I. Ershov, A.L. Kovalenko // Antibiot Khimioter. – 2008. -

Vol. 53(3-4). – Р. 36-45.

7. Scholtissek C. How to overcome resistance of influenza A viruses against

adamantane derivatives / C. Scholtissek, G. Quack, H.D. Klenk, R.G. Webster //

Antiviral Res. – 1998. - Vol. 37. – Р. 83-95.

8. Sheu T.G. Surveillance for Neuraminidase Inhibitor Resistance among

Human Influenza A and B Viruses Circulating Worldwide from 2004 to 2008 /

T.G. Sheu, V.M. Deyde, M. Okomo-Adhiambo, R. Garten // Antimicrob Agents

Chemother. – 2008. - Vol. 52(9). – Р. 3284-3292.

9. Woodhead M. Neuraminidase inhibitors: progress in the management of

influenza / M. Woodhead, D. Lavanchy, S. Johnston, P. Colman // Int. J. Clin. Pract.

– 2000. - Vol. 54(9). – Р. 604-610.


Zarubaev V.V. – Candidate of Biological Sciences, head of the laboratory of

the Chemotherapy of Virus Infections of the research institute of Influenza Northwest

department of the Russian Academy of Medical Science, tel.: 8(911) 928-04-95.


Firm «POLYSAN», Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.:

8(812)110-82-25,112-13-79, е-mail: [email protected], STPF «POLYSAN»

www.polysan.ru

Sologub Tamara Vasilievna – Doctor of Medicine, Professor, head of the

department of Infectious Diseases of the Saint-Petersburg State Medical Academy

named after I.I.Mechnikov of Roszdrav, tel./fax: 8-812-717-27-07, e-mail:

[email protected]



96



http://www.ncbi.nlm.nih.gov/pubmed/11220989?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

http://www.ncbi.nlm.nih.gov/pubmed/11220989?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2



[email protected]

Petrov A.Yu. - Candidate of Pharmaceutical Sciences, head of the research

laboratory of the Open Company “POLYSAN”, tel.: 8(812) 710-82-25.


1288 Шведова

UDC 616.9:616.428-053.2/.6:615.37

© N.M. Shvedova, E.V. Mikhailova, S.A. Khmilevskaya, 2010

Shvedova N.M., Mikhailova E.V., Khmilevskaya S.A.Epstein-Barr virus

mononucleosis in children. Pharmacoeconomical substantiation of immunotropic

therapy // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.132-137.

State Educational Establishment of High Professional Training «Saratov State


of the Russian Federation», 410710, Saratov, Kazachiya str., 112, tel.: 8(845) 251-12-

87.

S u m m a r y : The research results are presented in the work. 299 patients

aged 4–14 with primary Epstein-Barr viral infection have been observed. Features of

a current infectious mononucleosis are revealed at different kinds of

immunocorrection therapy. The сlinical – economic estimation of immunocorrection

therapy is spent at primary Epstein-Barr virus infection

K е y w o r d s : Epstein-Barr viral infection; immunocorrection therapy;

сlinical-economic substantiation.

R e f e r e n c e s

1. Инфекционные болезни у детей / Под ред. В.Н.Тимченко. - С.-Пб.:

СпецЛит, 2006. – 420 с.

2. Зайцева И.А. Инфекционный мононуклеоз у детей / И.А Зайцева,

С.А. Хмилевская, И.А. Бережнова // Детские инфекции: Научно-практический

журнал ассоциации педиатров-инфекционистов. - 2004. - №3 .- С. 65-68.

97

3. Патогенетическое обоснование иммунокоррегирующей терапии при

инфекционном мононуклеозе у детей. / В.В. Фомин и др. // Детские инфекции. -

2006. - №3. - С. 23-26

4. Потарская Е.В. Клинические особенности течения Эпштейна-Барра

вирусной инфекции у детей, перенесших инфекционный мононуклеоз /

Е.В. Потарская, А.П. Помогаева, О.И. Уразова // Вопросы современной

педиатрии. – 2006. – Т. 5. - № 5. – С. 112-117.

5. Рудакова А.В. Фармакоэкономический анализ в организации

централизованного лекарственного обеспечения / А.В. Рудакова . – С-Пб.:

СпецЛит, 2004. – 26 с.

6. Тимченко В.Н. Новый иммунокорректор - циклоферон для

педиатрической практики: Учебн. Пособие / В.Н. Тимченко, Л.Г. Горячева,

М.Г. Романцов. - СПб., 2000. – 15 с.

7. Учайкин В.Ф. Информация о профилактической и терапевтической

эффективности препарата арбидол при гриппе, других острых респираторных

вирусных инфекциях, ротавирусной инфекции, инфекционном мононуклеозе у

детей / В.Ф. Учайкин. - М., 2005. – 35 с.

8. Феклисова Л.В. Клиника, диагностика и лечение инфекционного

мононуклеоза у детей. Пособие для врачей / Л.В. Феклисова, Е.Р. Мескина,

Л.А. Галкина, С.П. Казакова. - М.- 2004, - 23 с.

9. Фомин В.В. О возможных механизмах гиперчувствительности

немедленного типа при инфекционном мононуклеозе у детей / В.В. Фомин,

Е.Е. Удилова // Уральский медицинский журнал. - 2007. - №3(31). - С.14-20.

10. Харламова Ф.С. Вирусы семейства герпеса и иммунитет / Ф.С.

Харламова // Детские инфекции. - 2006. - Т. 5. - № 3. - С. 30-33.

11. Хмилевская С.А. Эпштейна - Барра вирусная инфекция у детей:

особенности цитокинового ответа и иммунопатологические реакции /

С.А. Хмилевская, И.А. Зайцева // Саратовский научно-медицинский журнал. –

2009. – Т. 5. - № 2. – С. 222

98

12. Чуйкова К.И. Эффективность лечения инфекционного мононуклеоза

Анафероном детским / К.И. Чуйкова, Л.А. Журавлева // Детские инфекции. -

2006. - №3. - С. 66-69.

13. Эпштейна-Барра вирусная инфекция у детей: современные подходы к

диагностике и лечению / Э.Н. Симованьян и др. // Лечащий врач: медицинский

научно-практический журнал. - 2007. - №7. - С. 36-41.


Shvedova Natalya Mikhaylovna - assistant Head of Department of Children

Infectious Diseases, Saratov State Medical University. Tel.: 8(452) 56-08-76, е-mail:

[email protected]

Mikhaylova Yelena Vladimirovna - doctor of Medical Science, professor,

Saratov State Medical University, Head of Department of Children Infectious

Diseases. Tel.: 8(452)26-32-77, е-mail: [email protected]

Khmilevskaya Svetlana Anatolyevna - candidate of Medical Science, аssociate

рrofessor, Saratov State Medical University, Department of Children Infectious

Diseases. Tel.: 8(927) 226-50-11, е-mail: hmils @ mail . ru


1271 Хайитов

UDC 616.36-002:615.38

© R.Kh. Khayitov, Н.Yu. Akhmedova, 2010

Khayitov R.Kh., Akhmedova H.Yu. On causes and possibility of frequency rate

decrease of human HBV, HCV and HIV infection through donor blood // Preventive

and clinical medicine. – 2010. - № 1 (34). – Р.137-139.

Research Institute of Epidemiology, Microbiology & Infection Diseases, 2,

Reshetov str, Tashkent, 100133, Republic of Uzbekistan, tel.: 8(998-71) 143-36-05,

fax 8(998-71) 275-66-92, е-mail: [email protected].

S u m m a r y : 73 blood and lymphocyte samples from blood donors have

been tested by ELISA. One HBsAg positive blood serum sample has been revealed

and HIV markers were not revealed. 9 HBsAg one HIV markers positive

99




lymphocytes samples have been revealed. These results with justification of

lymphotpropic features of HBV and HIV indicate the great practical value of these

features of viruses, improving the quality and reduction of false-negative results

during ELISA of blood donor’s samples for HBsAg and HIV.

K e y w o r d s : HBV; HCV; HIV; donor blood.

R e f e r e n c e s

1. Жибурт Е.Б. Возможности ранней диагностики вирусных

заболеваний / Е.Б. Жибурт, А.Х. Асади, Е.Г. Черкасов, П.В. Рейзман //

Ж.микроб.эпидем.и иммунобиол. – 2005. - №5. - С. 71-73.

2. Закономерности персистенции HCV в плазме и лейкоцитах при

хронической HCV-инфекции / О.О. Знойко [и др.] // Российский журнал

гастроэнтерологии, гепатологии, колопроктологии. - 2000. - №4. - С. 59-64.

3. Alter H.J. To C or to not to C: These are the guestions / H.J. Alter // Blood. -

1995. - №85. - P. 81-95.


Khaitov Ravshan Khurramovich – reanimatologist, Research Institute of

Epidemiology, Microbiology & Infection Diseases under Ministry of Health of the

Republic of Uzbekistan, tel.: 8(998-71) 243-36-05, e-mail: [email protected]

Akhmedova Halida Yuldashevna - Philosophy Doctor (doctor) of medical

science, Research Institute of Epidemiology, Microbiology & Infection Diseases

under Ministry of Health of the Republic of Uzbekistan, tel.: 8(+99897) 705-48-96,

fax: 8(998-71) 275-66-92, e-mail: [email protected]


1292 Александрова

UDC [616.314.17|.18-008.1-06:616-002.5]-092(045)

© E.A. Aleksandrova, N.E. Kazimirova, A.V. Lepilin, A.A. Shuldyakov, 2010

Aleksandrova E.A., Kazimirova N.E., Lepilin A.V., Shuldyakov A.A. Clinical-

pathogenetic aspects of periodontitis development in patients with pulmonary

tuberculosis // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.139-142.

100



State Educational Establishment of High Professional Training «Saratov State


of the Russian Federation», 410710, Saratov, Kazachiya str., 112, tel.: (8452) 27-33-

70, 51-15-32 fax: (8452) 51-15-34, 51-16-17 Е-mail: [email protected]

http://www.sgmu.ru

S u m m a r y : With the purpose to study the mechanisms of formation and

peculiarities of periodontitis course in patients against the background of focal

tuberculosis, the examination of 45 patients divided into three basic groups (patients

with periodontitis and HIV-infection; patients with periodontitis; and HIV-infected

without periodontitis) has been carried out.

It was determined, that the patients with periodontitis and focal tuberculosis

had the development of local inflammatory reaction with infectious assignment,

activation of anti-inflammatory cytokines in parodontal pockets’ fluid. It was also

proved, that the cause factor of frequent and long relapses in parodontal pathology in

focal tuberculosis was the development of pathologic process against the background

of endotoxicosis syndrome, disbalance of lipid peroxidation and antioxidant system.

K е y w o r d s : periodontitis; tuberculosis.

R e f e r e n c e s

1. Васильева Л.С. Клинические варианты течения туберкулеза легких как

проявление адаптационных реакций организма в условиях различных

эпидемиологических периодов / Л.С. Васильева, Т.П. Филиппова // Сибирский

медицинский журнал. - 2006. - №6. – С. 35-41.

2. Данилевский Н.Ф. Заболевания пародонта / Н.Ф. Данилевский. - Киев:

Здоровье, 2000. - 464 с.

3. Курякина Н.В. Заболевания пародонта / Н.В. Курякина, Т.Ф. Кутепова.

- Н.Новгород, 2000. – 158 с.

4. Шилова М.В. Туберкулез в России / М.В. Шилова. - Воронеж: ВГПУ,

2007. – 150 с.


101

http://www.sgmu.ru/


Aleksandrova Helen Aleksandrovna - the stomatologist of the therapeutic

department of № 1 consultative stomatological polyclinic on the profit and loss

accounting basis of clinical hospital, e-mail: [email protected]

Kazimirova Natalia Evgenyevna - doctor of medicine, professor, head of

department of Phtisiopneumology Saratov State Medical University , tel.: (8-8452)

46-12-11; e-mail: [email protected]

Lepilin Alexander Victorovich - doctor of medicine, professor, head of

department of surgical stomatology, Saratov State Medical University, tel.: (8-8452)

28-88-30

Shuldyakov Andrey Anatolyevich doctor of medicine, professor, head of

department of infectious disease, Saratov State Medical University, tel.: (8-8452) 58-

06-49, e-mail: [email protected]


1272 Ахмедова

UDC 616.61-008.64:616.34-022.7-036.11-053.2

© M.D. Akhmedova, I.A. Imamova, 2010

Akhmedova M.D., Imamova I.A. Early risk prognosis of acute renal insufficiency

development in acute enteric infections in children // Preventive and clinical

medicine. – 2010. - № 1 (34). – Р.142-145.




S u m m a r y : In 79 children acute intestinal infections (AII) the correlation

of dynamic of antigen-binding lymphocytes (ABL) level sensibilized for tissue

antigen (TA) of kidney and severity of acute renal failure have been studied. ABL for

the kidney tissue may indicate the acute renal failure risk and degree of ARF in

children with AII.

102



K e y w o r d s : acute intestinal infections, acute renal failure, antigen-

binding lymphocytes

R e f e r e n c e s

1. Габриэлян Н.И. Количественный метод определения СМП в сыворотке

крови / Н.И. Габриэлян, В.И. Липатова // Лаб. дело. - 1989.- №4. - С24-28.

2. Гариб Ф.Ю. Методы изучения субпопуляций лимфоцитов у человека

при патологических состояниях / Ф.Ю. Гариб, М.В. Залялиева // Методические

рекомендации. - Ташкент. - 1989. - 9 с.

3. Гулямов Н.Г. Клиника, диагностика и лечение почечной

недостаточности при ОКИ / Н.Г. Гулямов, И.А. Имамова, Т.К. Далимов // Инф.,

иммунитет и фармакология. - 2006. - №2. - С.41-43.

4. Гулямов Н.Г. Острая надпочечниковая недостаточность при

инфекционных заболеваниях / Н.Г. Гулямов, Т.К. Далимов // Инфекция,

иммунитет и фармакология. - 2006. - №2. - С. 39-41.

5. Диагностическое значение показателей антигенсвязывающих

лимфоцитов оценке поражения органов при инфекционной и неинфекционной

патологии / Н.Г. Гулямов, Х.Ю. Ахмедова, Т.К. Далимов, И.А. Имамова,

Ф.З. Юлдашева // Инфекция, иммунитет и фармакология. - 2005.- №3. - С. 115-

118.

6. Лукичев Б.Г. Острая почечная недостаточность: современное состояние

проблемы / Б.Г. Лукичев, И.В. Федотова // Нефрология. - 1999. - Т.3. - № 1.-

С. 20-36.

7. Наумова В.И. Почечная недостаточность у детей / В.И. Наумова,

А.В. Папаян. - Л.: Медицина, 1991. – 288 с.

8. The Spectrum Acute Renal Failure in the Intensive Care Unit / Fernando

Ziano et al. // Kidney International. - Vol.33. - Suppl.66. - 1998. – Р. 5-16.


Akhmedova Muborak Djalilovna – Philosophy Doctor (doctor) of medical

science, professor, director of Research Institute of Epidemiology, Microbiology &

103

Infection Diseases under Ministry of Health of the Republic of Uzbekistan, tel.

8(998-71) 243-36-05, fax 8(998-71) 275-66-92, е-mail: [email protected]

Imamova Ilmira Abdulaevna - postgraduate of department of Infection

Diseases and children Infections of Tashkent Medical Academy, Research Institute

of Epidemiology, Microbiology & Infection Diseases under Ministry of Health of the

Republic of Uzbekistan, tel.: 8(998-71) 243-36-05, fax: 8(998-71) 275-66-92, е-mail:

[email protected]


1273 Гулямов

UDC 616.927:616.45

© N.G. Gulyamov, T.K. Dalimov, D.B.Mirzajanova, 2010

Gulyamov N.G., Dalimov T.K., Mirzajanova D.B. Adrenal gland cortex

functional insufficiency in typhoid fever infection: hormonal and immunological

aspects of pathogenicity // Preventive and clinical medicine. – 2010. - № 1 (34). –

Р.145-148.




S u m m a r y : 67 patients with severe and moderate typhoid fever have

been tested for dynamic of cortisol, ACTG and ABL (antigen-binding

lymphocytes) against tissue antigen of adrenal cortex. The patients with signs of

glucocroticoidal failure there was reduction of cortisol on the background of ACTG

and ABL rise (up to 8.0% and over); ABL rise up to 4.0-6.0% on the background

of ACTG and cortisol rise is the early sign of glucocorticoidal failure.

K e y w o r d s : typhoid fever; cortisol; antigen-binding lymphocytes.

R e f e r e n c e s

1. Гариб Ф.Ю. Клиническая ценность определения антигенсвязывающих

лимфоцитов у больных брюшным тифом и другими заболеваниями /

104



Ф.Ю. Гариб, Н.И. Гурарий, Ю.И. Афанасьев // Метод. рекомендации. -

Ташкент. - 1983. - 4 с.

2. Гариб Ф.Ю. Методы изучения субпопуляций лимфоцитов у человека

при патологических состояниях / Ф.Ю. Гариб, М.В. Залялиева // Методические

рекомендации. – Ташкент, 1989. - 9 с.

3. Гулямов Н.Г. Критерии для раннего прогнозирования исходов при

брюшном тифе / Н.Г. Гулямов, М.Д. Ахмедова, Н.Х. Камалова // Методические

рекомендации. - Ташкент, 2004. - 20 с.

4. Гулямов Н.Г. Острая надпочечниковая недостаточность при

инфекционных заболеваниях / Н.Г. Гулямов, Т.К. Далимов // Инфекция,

иммунитет и фармакология. - 2006. - №2. - С. 39-41.

5. Диагностическое значение показателей антигенсвязывающих

лимфоцитов оценке поражения органов при инфекционной и неинфекционной

патологии / Н.Г. Гулямов, Х.Ю. Ахмедова, Т.К. Далимов, И.А. Имамова,

Ф.З. Юлдашева // Инфекция, иммунитет и фармакология. - 2005.- №3. - С. 115-

118.

6. Патологическая физиология эндокринной системы. Мет.рек.

Патологическая физиология / Под ред. А.Д. Адо и Л.М. Ишимовой. - М.:

Медицина, 1980. – 250 с.


Gulyamov Nariman Gulyamovich - chief of laboratory, Philosophy Doctor

(doctor) of medical science, professor, Research Institute of Epidemiology,

Microbiology & Infection Diseases under Ministry of Health of the Republic of

Uzbekistan, tel.: 8(998-71) 243-36-05, fax: 8(998-71) 275-66-92, e-mail:

[email protected]

Dalimov Tokhir Kenjabekovich - postgraduate of department of Infection

Diseases and children Infections of Tashkent Medical Academy, Research Institute

of Epidemiology, Microbiology & Infection Diseases under Ministry of Health of the

Republic of Uzbekistan, tel.: 8(99897) 336-47-30.


105


1274 Шоумаров

UDC 616.927: 615.371

© Shoumarov S.B., Gulyamov N.G., Smagin A.A., 2010

Shoumarov S.B., Gulyamov N.G., Smagin A.A. Causes and ways of

seronegativity formation overcoming in vaccinal prevention of typhoid fever //





S u m m a r y : 337 persons observed before and after vaccination with

typhoid fever vaccine (TFV) spirituous dry Russian Federation manufactured

(TVFSD RF). 157 additionally administered Timoptin™. Before vaccination

moderate weight proteins (MWP), O-antigen S. typhi titer before and 1 month after

vaccination were studied. The vaccination efficacy based on protective titer level

failed in 27.20% with positive effect in 73.80%. Seronegative persons MWP level

before vaccination exceeded the seropositive ones 1.5-2.02 fold. It reflects the

correlation of seronegativity forming with MWP level during vaccination. After

vaccination with stimulation by Timoptin the seronegative effect observed in 3.80%

against 27.20% in vaccinated persons without immune stimulation. Thus, Timoptin

application improved vaccination efficacy up to 96.20% against 73.80% with

vaccination without immune stimulation.

K e y w o r d s : abdominal fever; vaccination; Timoptin

R e f e r e n c e s

1. Брико Н.И. Вакцинопрофилактика кори, краснухи, коклюша и оценка

её эффективности / Н.И. Брико // Журн. Педиатрия. – 2001. - Т. 3. - №8. – С. 45-

47.

2. Брико Н.И. Критерии оценки эффективности вакцинации / Н.И.

Брико // Бюллетень «Вакцинация. Новости вакцинопрофилактики». - 2000. -

№11(5) -12 с.

106

3. Зверев В.В. Вакцинопрофилактика и биотерроризм / В.В. Зверев,

Б.Ф. Семенов // Бюллетень «Вакцинация». - 2002. - №3(21). – 10 с.

4. Иванов Б. Вакцинация против брюшного тифа: современное состояние

вопроса / Б. Иванов, M.M. Levine, P.H. Lambert // Бюллетень всемирной

организации здравоохранения. – 2003. – 20 с.

5. Биргер М.О. Справочник по микробиологическим и

вирусологическим методам исследования / Под ред. М.О. Биргера. - 3-е

издание переработанное и дополненное. – М.: Медицина, 1982 г. – 220 с.


Shoumarov Sanat Bakhravovich - Philosophy Doctor of medical science,

chief doctor of the republic center of sanitary-epidemiological control of the Republic

of Uzbekistan, tel.: 8(+99871) 273-03-17.

Gulyamov Nariman Gulyamovich - chief of laboratory, Philosophy Doctor

(doctor) of medical science, professor, Research Institute of Epidemiology,

Microbiology & Infection Diseases under Ministry of Health of the Republic of

Uzbekistan, tel.: 8(998-71) 243-36-05, fax: 8(998-71) 275-66-92, e-mail:

[email protected]

Smagin Artem Alexandrovich - Research assistance, Laboratory of chronic

infection, Research Institute of Epidemiology, Microbiology & Infection Diseases

under Ministry of Health of the Republic of Uzbekistan, tel:. 8(998-71) 243-36-05, е-



SCIENTIFIC REVIEWS1307 Гайковая

UDC 615.22:615.035

© L.B. Gaykovaya, G.A. Kukharchik, A.T. Burbello, T.V. Vavilova, 2010

Gaykovaya L.B., Kukharchik G.A., Burbello A.T., Vavilova T.V. Laboratory

studies in efficacy and safety evaluation of medicinal therapy of ischemic heart

disease // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.151-159.

107



State Educational Establishment of Higher Professional Training «Mechnikov





S u m m a r y : Standards of medicinal therapy in ischemic heart disease

include currently five and more medical products which action is directed on various

pathological processes: inflammation, apoptosis, hypercoagulability, atherosclerosis

etc. By means of various laboratory methods of diagnostics it is possible not only to

reveal pathological process, to specify the diagnosis, but also to estimate efficiency of

spent medicinal therapy, to pick up doses and to warn development of undesirable

collateral reactions. In given article the review of laboratory methods which can be

used at monitoring of medicinal therapy sick of an ischemic heart disease (IHT), an

acute coronary syndrome, including a myocardial infarction and their importance in

the estimation of efficiency and safety of medicinal therapy is resulted. The value of

such testing for an estimation of pharmacotherapy is not defined. Modern methods of

laboratory diagnostics which are accessible but not used in every day clinical practice

are also considered in this review.

K e y w o r d s : Ischemic heart disease; laboratory methods; monitoring of

medicinal therapy; efficiency; safety.

R e f e r e n c e s

1. Бурбелло А.Т. О состоянии окислительно-восстановительных систем

организма при остром и хроническом отравлении нитритом натрия /

А.Т. Бурбелло, Г.А. Баскович, Е.Г. Доброхотова // Гигиена труда и проф.

заболеваний. – 1990. - №6. – С. 29-32

2. Бурбелло А.Т. Мембраностабилизирующие свойства виолуровой

кислоты / А.Т. Бурбелло, А.Ф. Сафонова, В.В.Вшивцева. - СПб, 1992. - Деп. в

ВИНИТИ, 07.10.1992. - № 3038-В15.

3. Бурбелло А.Т. Омега-3 ПНЖК. 15-летний опыт клинического

применения при различных патологических состояниях / А.Т. Бурбелло,

108



Л.Б. Гайковая // Клиническая фармакология и терапия. – 2009. - № 6. – С. 135-

137.

4. Вавилова Т.В. Антитромботическая терапия и методы ее лабораторного

контроля (лекция) / Т.В. Вавилова // Клиническая лабораторная диагностика. -

2004. - №12. - С.21-32.

5. Вавилова Т.В. Гемостазиология в клинической практике (пособие для

врачей) / Т.В. Вавилова. - СПб.: Издательство СПбГМУ им. акад.И.П.Павлова,

2005. - 92с.

6. Вавилова Т.В. Антитромботическая терапия в клинической практике.

Принципы проведения и лабораторный контроль (пособие для врачей) /

Т.В. Вавилова. - СПб.: СПбГМА им.И.И.Мечникова, 2008. - 84 с.

7. Внезапная сердечная смерть. Рекомендации Европейского

Кардиологического общества / Под ред. проф. Н.А. Мазур. – М., 2003. – 148 с.

8. Вопросы современной проточной цитометрии. Клиническое

применение / Под ред. С.В. Хайдукова, А.В. Зурочки. – Челябинск, 2008. –

195с.

9. Гайковая Л.Б. Комплексная лабораторная оценка действия омега-3

ПНЖК у больных инфарктом миокарда / Л.Б. Гайковая // Медицинская

иммунология. - 2009. - Т.11. - №4-5. - С.467.

10. Громнацкий Н.И. Гипотензивное и гемодинамическое действие

кардиоселективного β1-адреноблокатора у больных артериальной гипертензией

/ Н.И. Громнацкий, В.Г. Шарова, О.В. Водяник // Сб. научно-практических

статей «Конкор. Опыт применения в клинической практике». - М.: РКИ Северо-

пресс, 2002. - С.31-36.

11. Дейвид Дж. Майро Современные перспективы применения статинов /

Дж. Майрон Дейвид, Фазио Сергио, Ф. Линтон МакРаэ // Международный

медицинский журнал. - 2000. - № 6. - С.126-134.

12. Диагностика и коррекция нарушений липидного обмена с целью

профилактики и лечения атеросклероза. Российские рекомендации. III

109

пересмотр. Приложение к журналу «Кардиоваскулярная терапия и

профилактика». - Москва. - 2007. – 26 с.

13. Кукес В.Г. Клиническая фармакокинетика - основа лабораторного

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http://www.ncbi.nlm.nih.gov/pubmed?term=%22Kliment%20CR%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

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Gaykovaya Larisa Borisovna – the candidate of medical sciences, the senior

lecturer of hospital therapy educational department with courses of family medicine,

clinical pharmacology and clinical laboratory diagnostics, the head of the central

113

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Talukder%20MA%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Zweier%20JL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Zweier%20JL%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

javascript:AL_get(this,%20'jour',%20'Free%20Radic%20Biol%20Med.');

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http://www.ncbi.nlm.nih.gov/pubmed?term=%22van%20Deel%20ED%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

http://www.ncbi.nlm.nih.gov/pubmed?term=%22van%20Deel%20ED%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract

laboratory diagnostic department of the St.-Petersburg state medical academy named

by I.I.Mechnikov, work tel./fax: (812) 545-06-32, e-mail: [email protected]

Kukharchik Galina Alexandrovna - candidate of medical sciences, Associate

Professor, St. Petersburg State Medical Academy (I.I. Mechnikov), work tel.: (812)


Burbello Alexander Timofeevna – the doctor of medical sciences, the

professor, managing a course of clinical pharmacology of chair of hospital therapy of

the St.-Petersburg state medical academy of I.I.Mechnikov, work tel.: (812) 543-50-

05, e-mail: [email protected]

Vavilova Tatyana Vladimirovna – the doctor of medical sciences, the professor

of chair of hospital therapy with courses of family medicine, clinical pharmacology

and the clinical laboratory diagnostics, managing a course of clinical laboratory

diagnostics of the St.-Petersburg state medical academy of I.I.Mechnikov, work tel.:

(812) 544-34-60, fax (812) 545-06-32, e-mail: [email protected]


1313 Романцов, Исаков UDC 616.523-08

© M.G. Romantsov, V.A. Isakov, S.B. Rybalkin, V.V. Krasnov, A.L. Kovalenko,

2010

Romantsov M. G, Isakov V. A., Rybalkin S.B., Krasnov V. V., Kovalenko A.L.

Modern approaches to the treatment of herpetic infection // Preventive and clinical

medicine. – 2010. - № 1 (34). – Р.159-171.1State Educational Establishment of Higher Professional Training «Mechnikov




[email protected]; www.mechnik.spb.ru2State Educational Establishment of Higher Professional Training «Pavlov St.-

Petersburg State Medical University of the Federal Agency for Public Health and

114




http://mail.yandex.ru/neo/[email protected]



Social Development of the Russian Federation», 197022, Lva Tolstogo str., 6-8, tel.:

234-08-21, fax: 234-01-25, e-mail: [email protected]’s oblast center for specialization Medical Aid. Russia, 440026, Penza,

Kuibischev str. 33а. Tel.: (8412) 32-11-29.4Nizhny Novgorod State Medical Academy, Russia, 603600, Nizhny Novgorod,

Minin and Pozharsky Square, 10/1, tel.: 8-381-239-09-43.5State Educational Establishment of High Professional Training «Saratov State


of the Russian Federation» (SEE HPT «Saratov SMU of Roszdrav), 410710, Saratov,

Kazachiya str., 112, tel.: 8-845-251-12-87. 6Scientific-Technological Pharmaceutical Firm “POLYSAN”, Russia, 191119,



S u m m a r y : The review is devoted to the modern approach to the therapy

of various clinical forms of herpetic infection (genital, herpes-virus skin infection,

herpes-virus infection type 4 – Epstein-Barr viral infection, infectious

mononucleosis). Factors leading to virus activation and its transition from a latent

form to an active state are described. Genital herpes is characterized. Cycloferon use

in experiment in Vero cell culture is proved, Cycloferon use in herpetic infection is

substantiated.

Cycloferon and cycloferon with acetilovir pharmacotherapeutic and economic

efficiency is shown. It was found that disease outcome resulting in clinical remission

is higher in patients in whom cycloferon is used.

Comparative data on cycloferon liniment and virolex cream application are

given in herpetic skin infections. Advantage of cycloferon liniment use as a means of

local therapy is given. Positive dynamics of cycloferon application for local treatment

of patients with herpes zoster was registered. The authors consider that the

association of herpes-viruses with active participation of opportunistic

microorganisms is involved in the formation of a clinical picture of infectious

mononucleosis. Cycloferon promotes quicker termination of virus activation, allows

115



to reduce antibiotics use, to minimize by-effects characteristic for chemopreparations.

In 91.7 % of cases of papilloma viral infection, cycloferon promoted prevention of

the infection manifestation, two times decreased the frequency of relapses with more

than 3-fold increase of inter-recurrent period. Restoration of epithelium

morphofunctional state in the areas of herpetic infection was found in 83.3 % of

patients receiving cycloferon as a part of a combined therapy.

K e y w o r d s : genital herpes; herpes-virus skin infection; herpes-virus

infection type4– Epstein-Barr virus infection; infectious mononucleosis; treatment

with cycloferon and cycloferon with acyclovirus.

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показателей иммунограммы //Иммунная недостаточность. М.,-2003.-С.230-294.

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2003.-18с.

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[email protected]


Firm “POLYSAN”, Russia, 191119, Saint-Petersburg, Ligovsky prospect, 112, tel.:

8(812)110-82-25,112-13-79, е-mail: [email protected], STPF “POLYSAN”

www.polysan.ru


PERSONNEL TRAININGUDC 614.23:616.89

1315 Гребенюк

© T.B. Grebenyuk, M.G. Romantsov, T.V. Sologub, G.G. Danilenkova 2010

Grebenyuk T.B. 2, Romantsov M.G. 1, Sologub T.V. 1, Danilenkova G.G. 2

Principles of constructive pedagogics in educational process of higher medical

schools // Preventive and clinical medicine. – 2010. - № 1 (34). – Р.171-177.1Saint-Petersburg state medical academy named after I. I. Mechnicov, Saint-


13-39, fax: 8(812)545-13-39. E-mail: [email protected] educational institution for higher professional training “I. Kant Russian

State University”, 236041, Russia, Kaliningrad, Alexander Nevsky street, 14

S u m m a r y : The article deals with the problems concerning introduction

of Bologna declaration recommendations into educational process of the future

specialists. From the stand point of constructive pedagogics, intensification of

training is suggested, using elements of educational process optimization on the basis

of the modern pedagogical technologies promoting improvement of specialist

training. The evaluation of students’ knowledge, different from the traditional one is

119



offered depending on the level of training. Attention is given to the problem training

combining inductive and deductive methods, providing activization of informative

activity of students.

K e y w o r d s : Bologna declaration; problem training; constructive

pedagogics; intensification and training optimization.

R e f e r e n c e s

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Romantsov Michail Grigorievich Doctor of Medicine, Candidate of

Pedagogical Sciences, Professor of the department of Infectious Diseases of

I.I.Mechnikov St.-Petersburg State Medical Academy. St.-Petersburg, Piskarevsky

prospect, 47, 195067; ph. 8-812-717-27-07; St.-Petersburg, 196244, Vitebsk

prospect, 33, bd. 2, apt. 89; Tel.: 8-812-379-39-46. An E-mail–[email protected]

Sologub Tamara Vasilievna, Doctor of Medicine, Professor, Honored Doctor

of Russia, head of the department of Infectious Diseases of I.I.Mechnikov St.-

Petersburg State Medical Academy of Roszdrav, tel./fax: 8-812-717-27-07, e-mail:

[email protected].

Grebenyuk T.B. - Doctor of Pedagogical Sciences, Professor, head of the

department of Pedagogics and Psychology of I.Kant Russian State University.

Danilenkova G. G - Candidate of Pedagogical Sciences, Assistant-Professor of

the department of Pedagogics and Psychology of I.Kant Russian State University.


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THE MINISTRY OF PUBLIC HEALTH AND SOCIAL ... · Web viewreventive and clinical medicine (HERALD . OF THE MECHNIKOV . SAINT-PETERSBURG STATE MEDICAL ACADEMY) № 1(34) 2010. 4 issues