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THE MOST BALANCED COVERAGE of biology and chemistry of any one-semester biochemistry text

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The most balanced COVERAGE OF BIOLOGY AND CHEMISTRY

Dear Professor,

Oxford University Press is proud to announce the July 2011 publication of Biochemistry: The Molecular Basis of Life, Fifth Edition, by Trudy McKee and James R. McKee.

As publisher for this trusted and respected textbook—now in its second edition with Oxford University Press—we would like to extend our warmest regards to our friends in the biochem-istry community and to guarantee that the fifth edition and the supplements that accompany it will be ready and available in July, in plenty of time for fall classes.

The fifth edition of McKee & McKee again provides the right balance between chemical andbiological principles, for the coverage you want and the relevance your students need in a one-semester course. We are proud to announce a new partnership with Sapling Learning, which will make available to McKee adopters a fantastic online homework system. This system makes assigning and grading homework a snap. Teaching and learning biochemistry will be easier and more efficient than ever before.

As a Not-For-Profit publisher, Oxford University Press USA is uniquely situated to offer the highest-quality scholarship at the lowest possible prices. Sapling Learning’s commitment to high-quality content, customer service, and low prices makes them a perfect fit in this endeavor.

We invite you to take a guided tour of the new edition and the two advance chapters provided here. We believe you will find that Trudy and James McKee and Oxford University Press have prepared a new edition of exceptional quality and value for your students.

Sincerely,

Jason Noe Jason KramerSenior Editor Marketing ManagerOxford University Press Oxford University Press

“ This is the best one-semester biochemistry book available.”! RANDOLPH A. COLEMAN,

COLLEGE OF WILLIAM & MARY

SAPLING LEARNING ONLINE HOMEWORK SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

OVERVIEW. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

INSTRUCTOR AND STUDENT SUPPLEMENTS PACKAGE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

ILLUSTRATED WALK"THROUGH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

ENDORSEMENTS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

SCHOOLS ADOPTING MCKEE & MCKEE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

ANNOTATED TABLE OF CONTENTS FOR THE FIFTH EDITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

SAMPLE CHAPTERS FROM THE FIFTH EDITION: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ?

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ?

Table of Contents FOR THE GUIDED TOUR

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Sapling Learning Benefits This online homework system is a powerful and effective tool for your biochem-istry courses.

NEW! Online Homework System from Sapling Learning Oxford University Press has partnered with Sapling Learning to produce an online homework and instructional solution for the Biochemistry: The Molecular Basis of Life textbook. The text that presents the coverage you need with the relevance your students want is now available with the most powerful online homework system in the industry.

The goals of the partnership between Oxford University Press and Sapling Learning are to:

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Chemical and Biological Principles in BalanceDesigned from the start for a one-semester survey course, McKee & McKee introduces students to the fascinating world of biochemical principles with just

neither too deep nor too shallow a fashion, helping students to see not just the details but also the bigger picture that connects these fields.

Real-World RelevanceFrom new chapter-opening vignettes through vivid in-chapter essays and fully integrated coverage, the authors consistently connect important biochemical principles to the worlds of medicine, nutrition, agriculture, bioengineering, and forensics. Students will understand both the relevance of biochemistry and the latest developments in the field.

Superior Problem-Solving ProgramThe fifth edition includes 20 percent more end-of-chapter problems—already doubled in the previous edition—now approximately 60 per chapter and the most in any textbook. The expanded problem sets span a range of difficulty and appli-cations, from basic practice problems to more challenging integrative exercises.

provide students with the opportunity to put their knowledge into action, right where new concepts are introduced. New with this edition, Sapling Learning’s Online Homework System is a powerful and effective tool for your course.

CurrencyThe fifth edition has been fully updated to include recent discoveries, including new discussions of epigenetics and the epigenome and the contribution of dietary fructose to the current epidemics of obesity and type II diabetes. Other enhanced coverage concerns protein folding, glucose transport mechanisms, macromolecu-lar crowding, RNAi, gene silencing, molecular chaperones, and biotechnology, to keep students up to date and poised for further study.

Simple, Clear IllustrationsWith dozens of new and enhanced figures, now also expanded and re-labeled for lecture display, the fifth edition of McKee & McKee incorporates a superior art program designed to help students develop a strong visual grasp of biochemical processes.

IN ONE SEMESTER: THE COVERAGE YOU WANT. THE RELEVANCE YOUR STUDENTS NEED.

YOU CAN HAVE IT ALL IN ONE SEMESTER.

“ The integration of biochemical facts into a meaningful biological context is a wonderful goal, particularly for a one-semester course. I applaud the increased chemistry content, particularly the addition of the four mentioned enzyme mechanisms. The revised problem sets will cer-tainly enhance the value of the text.”

—C. Martin Lawrence, Montana State University

“ The authors recognize the continued need to be current and relevant—a fact often ignored by other authors. I have been lecturing on macromo-lecular crowding for years—it is a topic often completely ignored or given short shrift.”

—Kenneth O. Willeford, Mississippi State University

Biochemistry: The Molecular Basis of Life is the ideal text for students who do not specialize in bio-chemistry but who require a strong grasp of biochemical principles. The goal of this edition has been to enrich the coverage of chemistry while better highlighting the biological context. Once concepts and problem-solving skills have been mastered, students are prepared to tackle the complexities of science, modern life, and their chosen professions.

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A POWERFUL TEACHING PACKAGEThe fifth edition of Biochemistry: The Molecular Basis of Life is accompanied by a variety of ancillary materials for both instructors and students, including an all-new online homework system from Sapling Learning (see page 5 for details).

Please visit the companion website (www.oup.com/us/McKee) to access lecture and assessment resources and interactive student study aids.

FOR INSTRUCTORSAll text images in enhanced electronic format: Instructors who adopt the fifth edition of McKee & McKee gain access to every illustration, photo, figure caption, and table from the text in high-resolution electronic format. Labels have been enlarged and multi-part figures have been broken down into separate components, for clearer projection in large lecture halls. Images are available on both the Instructor’s Resource

Test Bank for Instructors: Written by the authors, the Test Bank includes more than 700 questions that are provided as editable Word files that can be easily customized.

Lecture Notes Slides for each chapter of the text:(University of the Ozarks), this set of more than 1100 editable lecture notes slides makes preparing lectures faster and easier than ever. Available in PowerPoint format

website.

FOR STUDENTS Student Study Guide and Solutions Manual: Written by authors Patricia DePra and Michael G. Sehorn (Clemson University), this manual provides the solutions to all of the exercises from the text. Each and every solution has been independently checked for accuracy by a panel of expert reviewers. (ISBN 9780199730971)

Web Quizzes: Students seeking an online resource to test their knowledge of

questions written by Dan Sullivan (University of Nebraska at Omaha). Students receive a feedback summary with each graded quiz.

Interactive 3-D Molecules: Grand Valley

State University) has created more than 300 interactive 3-D molecules in JMOL format. Students can manipulate and study individual molecules and their structures, take self-guided concept tutorials, and test their molecule-recognition abilities by working through the all-new interactive self-quizzes.

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A ROBUST BIOCHEMISTRY LEARNING SYSTEM

Biochemistry in Perspective essays show students the real-world relevance of the biochemical processes they are studying. The fifth edition includes nine new essays, each of which begins with an engaging, thought-provoking ques-tion and ends with a concept summary statement to help students see the big picture. These and more than two dozen additional essays from past editions are also available online.

Biochemistry in the Lab boxes introduce both classic and modern experimental techniques, reinforcing the fact that the best way to learn science is by doing science!

Overview sections

summaries, suggested readings, and key-word lists provide students with pedagogical support, reinforcing what they have learned and guiding them toward further inquiry. Frequent in-

links to Web resources complete the step-by-step learning system.

Chapter-Opening VignettesAll new to this edition, these vignettes grab student attention from the start and connect biochemical principles and dis-coveries to such subjects as human dis-orders, climate change, and the nature of life itself.

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A ROBUST BIOCHEMISTRY LEARNING SYSTEM

An unparalleled problem-solving system provides multiple opportu-nities and methods for developing strong quantitative and analytical skills. These include hundreds of in-chapter Questions based on real-world applications and end-of-chap-ter Review and Thought Questions.

Vivid and accurate figures illuminate the text discussion, visually illustrating important concepts and processes.

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A highly trusted textbook a biological context is excellent. I welcome the increased depth of chemistry coverage emphasizing the most important reactions. I also welcome the increased connection between biochemistry and human biology. This edition is evolving beautifully. . . . From what I’ve seen, I prefer the new McKee textbook to the book that I am cur-

—Christine A. Hrycyna, Purdue University

and disorders to the understanding of key biochemical concepts. My students appreciate the ‘Biochemistry in Perspective’ essays in each chapter. Once again McKee has done a fabulous job of providing clear illustrations. I feel the fifth edition has done very well in balancing both the chemical and biological concepts. The revisions will make

—Anjuli Datta, Pennsylvania State University

context to me is the most important goal. In this manner students can derive the connection between the facts and how they lead to eluci-dating the principle of the topic being introduced. I like the style: it begins with very simple down-to-earth discussion and gradually gets into the more complex and sophisticated aspects. The vignettes at the beginning of the chapters and the use of Thought Questions at the end are very appealing. The introduction and discussion of a disease directly related to the topic being discussed will stimulate students’

—Ralph A. Stephani, St. Johns University

end of the chapters. I like that they are increasing the chemistry. I really like the format of the questions at the end of the chapter. They start out easy and build up in complexity. The Thought Questions push the students to look at the big picture. My students really like the Biochemistry in the Lab sections. They get excited about the con-

—Tamara L., Hendrickson, Wayne State University

and biology. This text is really interesting to read and nicely illus-trated. I like most the idea that biochemical reactions should be shown integrated in the context of the cellular anatomy and functions. The proposed revisions about RNA interference and chromate code give

—Max Sokolov, West Virginia University

“ I have always appreciated the bal-ance in previous editions, and the inclusion of more chemistry (enzyme mechanisms) is great! Increased relevance is important, too! I appre-ciate the inclusion of systems biol-ogy topics and macromolecular crowding. Essays and boxes add just the right flavor to the text to make it really come alive in a practical kind of way. It is the best one-semester biochemistry book available.”

—Randolph A. Coleman, College of William & Mary

“ I love the vignettes because I teach with a lot of examples from my personal scientific and educational experience. This type of thing often helps to get the students to under-stand where a given topic fits into the real-world situation.”

—Ruth E. Birch, St. Louis University

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Birmingham

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University of DelawareUniversity of Findlay, TheUniversity of Kentucky University of Maine at Presque Isle University of MemphisUniversity of Michigan-Ann ArborUniversity of Minnesota-Duluth

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at WilmingtonUniversity of Rhode IslandUniversity of Texas, Permian Basin University of Texas Health Science

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Vancouver Wayne State University

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Schools Adopting McKee & McKee

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1. BIOCHEMISTRY: AN INTRODUCTION

1.1 What is Life?1.2 BiomoleculesFunctional Groups of Organic Biomolecules

1.3 Factory?Biochemical ReactionsEnergyOverview of MetabolismBiological Order1.4 Systems BiologyEmergenceRobustnessModularityBiochemistry in the Lab: An Introduction

2. LIVING CELLS2.1 Basic ThemesWaterBiological MembranesSelf-AssemblyMolecular Machines

Signal Transduction2.2

Plasma Membrane

Pili and Flagella2.3Plasma MembraneEndoplasmic ReticulumGolgi ApparatusNucleusVesicular OrganellesMitochondriaPeroxisomesPlastids

Cytoskeleton: An expanded section introduces the concept of intraflagellar transport.Ribosomes

NEW! Biochemistry in Perspective: Primary Cilia and Human Disease: A new box describes how defects in the structural and functional properties of primary cilia contribute to human disease.

Biochemistry in the Lab: Cell TechnologyAvailable OnlineBiochemistry in Perspective: Organelles and Human Disease

3. WATER: THE MATRIX OF LIFE

3.1 Molecular Structure of Water3.2 Noncovalent BondingIonic InteractionsHydrogen BondsVan der Waals Forces3.3 Thermal Properties of Water3.4 Solvent Properties of Water

Structuring, and Sol-Gel TransitionsHydrophobic Molecules and the

Hydrophobic EffectAmphipathic MoleculesOsmotic Pressure3.5 Ionization of WaterAcids, Bases and pHBuffersPhysiological Buffers

NEW! Biochemistry in Perspective: Cell Volume Regulation and Metabolism: A new box describes the relation-ship between metabolic pathways and cell volume changes trig-gered by osmotic imbalances.

Available OnlineBiochemistry in Perspective: Water, Abiotic Stress, and Compatible Solutes

4. ENERGY4.1 ThermodynamicsFirst Law of ThermodynamicsSecond Law of Thermodynamics

4.2 Free Energy

The Hydrophobic Effect Revisited4.3 The Role of ATPBiochemistry in Perspective: Nonequilibrium ThermodynamicsAvailable OnlineBiochemistry in Perspective: The Extremophiles: Organisms that Make a Living in Hostile Environments

5. AMINO ACIDS, PEPTIDES, AND PROTEINS5.1 Amino Acids

Biologically Active Amino AcidsModified Amino Acids in ProteinsAmino Acid StereoisomersTitration of Amino AcidsAmino Acid Reactions5.2 Peptides5.3 ProteinsProtein StructureThe Folding Problem: An updated section describes molecular chaperone-assisted protein folding.Fibrous ProteinsGlobular Proteins 5.4 Molecular MachinesMotor Proteins

NEW! Biochemistry in Perspective: Spider Silk and Biomimetics: A new box describes the structural properties of spider silk fibers and the efforts of sci-entists to manufacture artificial spider silk.

Biochemistry in the Lab: Protein TechnologyAvailable OnlineBiochemistry in Perspective: Protein PoisonsBiochemistry in Perspective: Myosin: A Molecular MachineBiochemistry in the Lab: Protein Sequence Analysis: The Edman Degradation

CONTENTS FOR MCKEE & MCKEE, FIFTH EDITION

1200 dpi icon; 5/e palette

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6. ENZYMES6.1 Properties of Enzymes6.26.3 Enzyme KineticsMichaelis-Menten KineticsLineweaver-Burk PlotsMultisubstrate ReactionsEnzyme InhibitionEnzyme Kinetics, Metabolism and

6.4 Organic Reactions and the Transition StateThe Roles of Amino Acids in Enzyme

Effects of Temperature and pH on

Detailed Mechanisms of Enzyme

6.5 Enzyme Regulation

Allosteric Regulation

NEW! Biochemistry in Perspective: Alcohol Dehydrogenase: A Tale of Two Organisms: A new box describes the remarkable ability of the yeast Saccaromyces cerevisiae to synthesize ethanol, and the properties of human alcohol dehydrogenases.

Available OnlineBiochemistry in Perspective: Enzymes and Clinical MedicineBiochemistry in Perspective: Quantum Tunneling and Catalysis

7. CARBOHYDRATES7.1 MonosaccharidesMonosaccharide Stereoisomers

Reactions of MonosaccharidesImportant MonosaccharidesMonosaccharide Derivatives7.2 Disaccharides7.3 Polysaccharides

HomoglycansHeteroglycans7.4 GlycoconjugatesProteoglycansGlycoproteins7.5

NEW! Biochemistry in the Lab: Glycomics: A new box describes the major technologies used to determine the structure of complex carbohydrate molecules.

Available Online

NEW! Biochemistry in Perspective: Conversion of Fischer Monosaccharide Structure onto Haworth Structure

8. CARBOHYDRATE METABOLISM8.1 GlycolysisThe Reactions of the Glycolytic PathwayThe Fates of PyruvateThe Energetics of GlycolysisRegulation of Glycolysis8.2 GluconeogenesisGluconeogenesis ReactionsGluconeogenesis SubstratesGluconeogenesis Regulation8.3 The Pentose Phosphate Pathway8.4 Metabolism of Other Important SugarsFructose Metabolism8.5 Glycogen MetabolismGlycogenesisGlycogenolysisRegulation of Glycogen Metabolism

NEW! Biochemistry in Perspective: Saccharomyces Cerevisiae and the Crabtree Effect: A new box describes the metabolic mechanism whereby yeast cells convert glucose into ethanol molecules that kill competitor microbes.

NEW! Biochemistry in Perspective: Turbo Design Can Be Dangerous: A new box describes why turbo design pathways must be rigorously controlled.

Available OnlineBiochemistry in Perspective: Fermentation: An Ancient Heritage

9. METABOLISM I: THE CITRIC ACID CYCLE

9.1 Oxidation-Reduction Reactions

Aerobic Metabolism9.2

NEW! The Citric Acid Cycle and Human Disease

Biochemistry in Perspective: The Evolutionary History of the

10. METABOLISM II: ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION

10.1 Electron Transport

NEW! Electron Transport: The Fluid State Model vs. the Solid-State Model: A new section describes the structural and functional properties of the respirasome.

Electron Transport Inhibitors10.2 Oxidative Phosphorylation

ATP Synthesis

Uncoupled Electron Transport

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10.3Oxidative StressReactive Oxygen SpeciesAntioxidant Enzyme SystemsAntioxidant MoleculesBiochemistry in Perspective: Myocardial Infarct: Ischemia and Reperfusion: An expanded reading describes the damage caused by the reintroduction of oxygen after blood flow interruption in heart muscle.Available OnlineBiochemistry in Perspective: Hans Krebs and the Citric Acid Cycle.

11. LIPIDS AND MEMBRANES11.1Fatty AcidsThe Eicosanoids: An expanded discus-sion of the eicosanoids describes their biological functions and roles in human disease.TriacylglycerolsWax EstersPhospholipidsPhospholipases: A new section describes the functions of phospholi-pases.SphingolipidsSphingolipid Storage DiseasesIsoprenoidsLipoproteins11.2 MembranesMembrane Structure: A new section describes the structural and functional properties of the red blood cell mem-brane protein AE1.Membrane Function

NEW! Biochemistry in Perspective: Botulism and Membrane Function: A new box describes how botulinum toxin causes muscle paralysis by preventing membrane fusion in nerve cells.

Available OnlineBiochemistry in Perspective: Glucose-6-Phosphate Dehydrogenase Deficiency

12. LIPID METABOLISM12.1 Fatty Acids, Triacylglycerols, and the Lipoprotein Pathways: An expanded discussion focuses on the distribution of triacylglycerols to the body’s tissues after digestion, the tria-cylglycerol cycle, and glycerogenesis.Fatty Acid Degradation

AcidFatty Acid Oxidation: Double Bonds

Fatty Acid Biosynthesis: The structural and functional properties of fatty acid synthase are updated to reflect recent research. A new table compares the details of fatty acid b-oxidation and synthesis.Regulation of Fatty Acid Metabolism in Mammals: An expanded discussion places fatty acid metabolism regulation in the context of AMPK control of the body’s biochemical pathways.Lipoprotein Metabolism: The Endogenous Pathway: A new section focuses on the transport of synthesized lipid molecules from the liver to the body’s tissues.12.2 Membrane Lipid MetabolismPhospholipid MetabolismSphingolipid Metabolism12.3 Isoprenoid MetabolismCholesterol Metabolism: A new sec-tion describes the effects of selected drugs on the cholesterol biosynthetic pathway.Biochemistry in Perspective: Atherosclerosis: The revised box describes how LDLs trapped in arterial walls become depleted of antioxidants and then contribute to atherosclerotic damage.Biochemistry in Perspective: Biotransformation

13. PHOTSYNTHESIS13.1 Chlorophyll and Chloroplasts: A revised introduction provides a more detailed overview of oxygenic photo-synthesis in chloroplasts.13.2 Light13.3 Light Reactions: The Z-scheme is updated to reflect recent research.Photosystem II and Water OxidationPhotosystem I and NADPH Synthesis

Photophosphorylation13.4 The Light-Independent ReactionsThe Calvin Cycle: The Calvin cycle reactions are expanded to include the ribulose-1,5- bisphosphate carboxylase mechanism.Photorespiration

13.5 Regulation of Photosynthesis

Biochemistry in Perspective: Photosynthesis in the DeepAvailable OnlineBiochemistry in Perspective: Starch and Sucrose MetabolismBiochemistry in the Lab: Photosynthetic Studies

14. NITROGEN METABOLISM I: SYNTHESIS

14.1 Nitrogen FixationThe Nitrogen Fixation ReactionNitrogen Assimilation14.2 Amino Acid BiosynthesisAmino Acid Metabolism OverviewReactions of Amino GroupsSynthesis of the Amino Acids14.3 Biosynthetic Reactions Involving Amino Acids

Glutathione: A newly rewritten sec-tion focuses on the roles of this vitally important intracellular reducing agent.NeurotransmittersNucleotidesBiochemistry in Perspective: GasotransmittersAvailable OnlineBiochemistry in Perspective: The Amine Neurotransmitters: GABA and SerotoninBiochemistry in Perspective: Heme and Chlorophyll Biosynthesis

15. NITGROGEN METABOLISM II: DEGRADATION

15.1 Protein Turnover: A newly revised section focuses on the ubiquitin proteasomal and autophagy lysosomal systems.

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15.2DeaminationUrea Synthesis

Skeletons15.3 Degradation of Selected Neurotransmitters15.4 Nucleotide Degradation

Biochemistry in Perspective: Disorders of Amino Acid CatabolismAvailable OnlineBiochemistry in Perspective: GoutBiochemistry in Perspective: Heme Biotransformation

16. INTEGRATION OF METABOLISM16.1 Overview of Metabolism16.2 Hormones and Intercellular

Peptide Hormones: An expanded sec-tion provides a more detailed descrip-tion of how insulin binding to its receptor alters intracellular processes.Growth FactorsSteroid and Thyroid Hormone Mechanisms16.3 Metabolism in the Mammalian Body: Division of Labor: New empha-sis is placed on glucose transport mechanisms in the body’s organs.Gastrointestinal TractLiverMuscleAdipose TissueBrainKidney16.4The Feeding PhaseThe Fasting PhaseFeeding BehaviorBiochemistry in Perspective: Diabetes Mellitus: An extensively revised description of diabetes explains the causes and consequences of this metabolic disease.Biochemistry in Perspective: Obesity and the Metabolic Syndrome: The box is revised to reflect recent research, including the contribution of dietary

fructose to the current epidemics of obesity and metabolic syndrome.Available OnlineBiochemistry in Perspective: Mammalian Hormones and the Hormone Cascade System

17. NUCLEIC ACIDS17.1 DNADNA Structure: The Nature of Mutation: A newly revised and expanded discussion describes mutation types and several classes of mutagens.DNA Structure: The Genetic MaterialDNA Structure: Variations on a Theme

Genome Structure17.2 RNATransfer RNARibosomal RNAMessenger RNANoncoding RNA17.3 VirusesBacteriophage T4: A Viral LifestyleBiochemistry in the Lab: Nucleic Acid Methods

NEW! Biochemistry in Perspective: Epigenetics and the Epigenome: Genetic Inheritance Beyond DNA Base Sequences: A new box provides an accessible introduction to a mechanism that alters gene expression during development.

Biochemistry in Perspective: HIV: An updated boxed reading describes the infective mechanism of HIV.Available OnlineBiochemistry in Perspective: A Short History of DNA Research: the Early Days

18. GENETIC INFORMATION18.1 Genetic Information: Replication, Repair, and RecombinationDNA Replication: Expanded sections describe the functions of the prokary-otic and eukaryotic DNA polymerases.DNA Repair: An updated and expanded section describes transcrip-tion-associated, mismatch, and double-strand repair.

DNA Recombination18.2 TranscriptionTranscription in ProkaryotesTranscription in Eukaryotes: The struc-tural and functional properties of RNA pol II are updated.18.3 Gene ExpressionGene Expression in ProkaryotesGene Expression in Eukaryotes: A new section describes posttranscriptional gene silencing.Biochemistry in Perspective: GenomicsBiochemistry in Perspective: Carcinogenesis: A new section outlines the roles of tumor suppressors.

19. PROTEIN SYNTHESIS19.1

The Aminoacyl-tRNA Synthease Reaction19.2 Protein SynthesisProkaryotic Protein SynthesisEukaryotic Protein Synthesis: Eukaryotic translation initiation is updated. New sections describe mito-chondrial posttranslational protein import and mTOR-mediated transla-tion control.

NEW! Biochemistry in Perspective: Trapped Ribosomes: RNA to the Rescue: A new box describes the tactics used by living organisms to release ribosomes attempting to translate truncated mRNAs without stop codons.

Biochemistry in Perspective: Context-Dependent Coding RearrangementBiochemistry in the Lab: ProteomicsAvailable OnlineBiochemistry in Perspective: EF-Tu: A Motor Protein

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SAMPLE CHAPTERS

5 and 8

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