The North Texas Journal v24n25

8/6/2019 The North Texas Journal v24n25

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BI-WEEKLY Volume 24, Number 25 - June 24, 20

NEW TREATMENT FOR TYPE 2

DIABETES APPROVED

Page 5


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NEW TREATMENT FOR TYPE 2

DIABETES APPROVED

Page 5


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New Medicine Approved By FDA To Treat Type 2 Diabet

ARA) - Diabetes (both type 1 and type 2) affects ap-

proximately 25.8 million Americans and an estimated

220 million people worldwide. Type 2 diabetes is the

most common type, accounting for an estimated 90 to 95

percent of diabetes cases. Diabetes is a chronic disease

hat occurs when the body either does not properly pro-

duce, or use, the hormone insulin.

Now there is good news for people with type 2 dia-

betes. Boehringer Ingelheim Pharmaceuticals, Inc.

nd Eli Lilly and Company announced the U.S. Food

nd Drug Administration (FDA) recently approved

TRADJENTA(TM) (linagliptin) tablets, a new prescrip-

ion medication used along with diet and exercise, to

ower blood sugar in adults with type 2 diabetes.

TRADJENTA (pronounced TRAD gen ta) can be used

lone or with other commonly used medications for type

2 diabetes - metformin, sulfonylurea or pioglitazo

TRADJENTA lowered hemoglobin A1C (HbA1C

A1C) levels up to 0.7 percent (compared to placebo

clinical trials.

A1C is measured in people with diabetes to provide

index of blood sugar control for the previous twothree months.

TRADJENTA should not be used in patients with t

1 diabetes or for the treatment of diabetic ketoacid

(increased ketones in the blood or urine). It has not b

studied in combination with insulin.

Many people with type 2 diabetes are not able to c

trol their blood sugar with diet and exercise alone

may also require one or more medications, says

John Gerich, professor of medicine, at the Universit


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Rochester School of Medicine. The FDA approval of

TRADJENTA is exciting because there is only one dose

o remember for patients, regardless of kidney or liver

mpairment. With TRADJENTA, physicians will have

nother option for managing type 2 diabetes, a poten-

ially devastating condition.

TRADJENTA is a tablet that can be taken once a day,

with or without food. It lowers blood sugar by increasing

ncretin levels, which increase insulin levels after mealsnd throughout the day.

t was approved based on a clinical trial program which

ncluded approximately 4,000 adults with type 2 diabe-

es. Included in the program were placebo-controlled

tudies evaluating TRADJENTA alone and with other

ommonly-used medications for type 2 diabetes.

TRADJENTA lowered fasting plasma glucose (FPG)

ompared to placebo, when used as monotherapy and

n combination with metformin, sulfonylurea or piogli-

azone. FPG is used to determine glucose levels in a fast-

ng state, usually upon waking up in the morning.

t also lowered two-hour post-prandial glucose (PPG)

evels compared with placebo as monotherapy and when

used in combination with metformin. PPG is used to de-

ermine glucose levels after meals, usually two hours af-

er eating.

To learn more about TRADJENTA and for full prescrib-ng information visit: www.TRADJENTA.com or call

Boehringer Ingelheim Pharmaceuticals, Inc. at (800)

42-6257.

Please report any unexpected effects or product prob-

ems to the Boehringer Ingelheim Drug Information Unit

by calling (800) 542-6257.

What is TRADJENTA?

TRADJENTA is a prescription medicine that is usedlong with diet and exercise to lower blood sugar in

dults with type 2 diabetes. TRADJENTA is not for peo-

le with type 1 diabetes or for people with diabetic keto-

cidosis (increased ketones in the blood or urine).

t is not known if TRADJENTA(TM) (linagliptin) tab-

ets is safe and effective when used with insulin.

Important Safety Information

Who should not take TRADJENTA?

Do not take TRADJENTA if you are allergic to l

gliptin or any of the ingredients in TRADJENTA.

Symptoms of a serious allergic reaction to TRADJEN

are rash, raised red patches on your skin (hives), sw

ing of your face, lips, and throat that may cause dif

ty breathing or swallowing. If you have any symptof a serious allergic reaction, stop taking TRADJEN

and call your doctor right away.

What should I tell my doctor before taking TRADJ

TA?

Tell your doctor about all the medicines you take,

cluding prescription and non-prescription medicines

tamins, and herbal supplements.

Tell your doctor if you take other medicines that

lower your blood sugar, such as a sulfonylurea or

sulin. If you take TRADJENTA with another medi

that can cause low blood sugar (hypoglycemia), suc

a sulfonylurea or insulin, your risk of getting low bl

sugar is higher. The dose of your sulfonylurea m

cine or insulin may need to be lowered while you t

TRADJENTA. Signs and symptoms of low blood su

may include headache, drowsiness, weakness, dizzin

confusion, irritability, hunger, fast heart beat, sweat

or feeling jittery.

Also tell your doctor if you take rifampin (Rifadin

Rimactane(R), Rifater(R), Rifamate(R)), an antibi

that is used to treat tuberculosis.

TRADJENTA may affect the way other medicines w

and other medicines may affect how TRADJEN

works.

Tell your doctor if you are pregnant or planning to

come pregnant or are breastfeeding or plan to breastf

What are the possible side effects of TRADJENTA?

The most common side effects of TRADJENTA inc

stuffy or runny nose and sore throat.

You are encouraged to report negative side effect

prescription drugs to the FDA. Visit www.fda.gov/m

watch or call (800) FDA-1088.


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Job Opportunities Growing In The Criminal Justice Fie

ARA) - Careers in criminal justice are many and varied

nd continued growth is expected in the eld. Growth

mong careers in law enforcement and investigation is re-

ported at 22 percent, an above average gain, according to

he Bureau of Labor Statistics. The same published report

projects 9 percent growth among probation ofcers and

orrections personnel. This projection represents an aver-ge growth rate, but growth just the same.

To give you an idea of the options available in this growing

ndustry, Audrey Pasin, an attorney and full-time faculty

member in the criminal justice program at Brown Mackie

College - Greenville offers her advice.

Our graduates with an associates or bachelors degree or

with a certicate in the colleges criminal justice program

re equipped to pursue employment in diverse areas of the

riminal justice eld, Pasin says. Theyre exploring posi-

ions in both private and government sectors.

In the current economic climate, law enforcement posi-

ions in most big cities are tough to get. They tend to look

or people with a military background and prefer a can-

didate with a masters degree, says Pasin. Colleges like

Brown Mackie College - Greenville prepare students for

other options that require less time in school.

As a new class enters the Criminal Justice program, Pa-in asks students what they like to watch on TV to gauge

heir desired career direction within the eld. The numer-

ous popular forensics dramas sometimes prompt students

o enroll with unrealistic expectations. We train students

or supporting roles in a forensics unit; however, it gen-

rally takes at least a bachelors degree to understand the

cience required to become a crime scene analyst, says

Pasin. The majority of our students say they have come

o us for training so they can help people in trouble. Most

want to help kids.

A criminal justice degree or certicate provides a founda-

ion in human service elds, such as social work. This eld

lone offers many different types of positions. Social work-

rs provide assistance to adults and children coping with

difcult issues such as disabilities, inadequate housing,

unemployment, substance abuse and domestic conicts,

mong many others. Students can pursue opportunities as

probation ofcer, case worker, or even working with a

school or hospital to support those in need.

Another avenue of employment opportunities lies in

security industry. A multitude of businesses hire secu

guards and surveillance ofcers to guard people, m

chandise, money or equipment. Students can inquire ab

these positions at museums, department stores, banks

hospitals, to name a few. Training also provides entry

el opportunities as a private investigator, Pasin says.

surance companies, attorneys and individuals hire peo

to locate information on legal, nancial or personal m

ters. The court system employs security personnel, bail

custodians of evidence and record-keeping. Another g

place to look is the corrections industry for a position prison guard.

A career in one eld can transition into the other. As

dents broaden the scope of the search for employment, t

now look into open positions at both the public defend

and prosecutors ofces. Its amazing how much of

approach to criminal justice comes from understanding

ciety. Whos in the system, how the system works, P

says.

Criminal justice training focuses on sociology and pchology research. Students come away with a global

derstanding of how people operate and how a family fu

tions. Because of this social dynamic, the criminal jus

programs have applications in the family law and emp

ment law elds. In this economy, I encourage student

think broadly outside of traditional places, says Pasin


10/24

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community updates and more!


11/24Page 11

Set The Scene For Easy Outdoor Entertainin

ARA) - Its not hard to get people to come to an outdoor

gathering on a warm summers evening, and it should

be just as easy to pull together a memorable affair. To

make the most of your time and budget, look for low-

maintenance solutions that you can use throughout the

eason - and in summers yet to come. From the dishesyou serve to the way you decorate, the less work you

have to do, the more youll be able to enjoy the time with

your guests.

Get your backyard ready for summer gatherings with

hese easy tips:

* Decking - Having a great space where guests can gather

s the rst, and perhaps most essential, task. A deck gives

guests a place to relax and linger comfortably through-out your party. If youre concerned about the time youll

have to put into keeping your deck looking great, toss out

your old ideas of decks requiring careful maintenance

and attention year-round. Opt for the low maintenance

decking materials now on the market and your deck will

e ready to welcome guests when you are. TimberTechs

Earthwood Evolutions line offers hardwood style deck

materials that resist scratching, staining and fading, mak-

ing them ideal for those who want

look of wood without the exten

care it requires.

* Plants - As much as you want y

deck and gathering space to look go

you want guests to be impressed

the natural surroundings of your y

as well. Research perennial plants

thrive not just in your horticult

zone, but in the microclimate of y

home (your particular soil type,

exposure, etc.) Choose hardy pl

that dont require too much pr

ing or attention, but which provid

beautiful and varied backdrop. If

dont have a green thumb, talk toexperts at a local garden center to

tips on plant selection and care.

* Decor - From serving ware to seat

you can assemble all the elements of entertaining w

out too much stress. If you want to freshen up the loo

your deck, invest in weather-resistant outdoor furni

that can stand up to the elements and will look good

years to come. If new furniture isnt in your budget, l

for new cushions and covers that will resist spills tears. Instead of buying disposable serving ware, l

for shatter-proof plates and glasses that are dishwas

safe. Youll be doing the environment a favor and yo

always have it on hand - no more last-minute runs to

store when you run out of plastic cups.

* Food - Dont stress yourself out with a multi-cou

menu. Since its summer, let seasonal ingredients be

stars. Serve sliced or grilled fresh fruit for a sweet d

sert and rely on tried-and-true party favorites, but wa different spin. Instead of Buffalo wings, try Z

Cheater Wings that are about as easy - and delicious

it gets. Serve them with a fresh tossed salad and you

got summer on a plate.

Zesty Cheater Wings

Recipe by Kent Whitaker, provided by TimberTech


12/24

This recipe is so easy its almost like cheating. Put a

twist on chicken marinated in Italian dressing with a few

quick and easy ingredient additions.

Ingredients:

12 to 24 mini wings and drums

Zesty Italian dressing

Barbecue sauce

Minced green pepper

Minced onion

Parsley akes

Directions:

Marinate the chicken in equal parts of Italian dress

and barbecue sauce. Toss in some hot sauce and spoo

a few tablespoons of minced peppers, onions and so

dried parsley akes. Cover, chill for a couple of ho

and grill until juices run clear.


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The Changing Landscape Of Cancer TreatmenARA) - In his recent bestseller, The

Emperor of All Maladies: A Biogra-

phy of Cancer, cancer physician

nd researcher Siddhartha Mukher-

ee writes that a decade from now,

ts likely most Americans will knowt least one person with chronic my-

loid leukemia (CML).

Theres no epidemic here, CML is

till a rare disease. The same num-

bers of people are being diagnosed

with this form of blood cancer, or

eukemia, each year. Its just that

more and more people with CML are

iving out their lives. This is due to a

undamental change in how this can-

er is treated.

The research leading to the new gen-

ration of medicines for CML spans

decades, with hundreds of scientists

round the world devoting their ca-

eers to understanding this mysterious disease. A key ad-

vance was made in the 1970s, with the discovery of possibly

he rst human oncogene (cancer-causing gene), Bcr-Abl.

A ip-op of two pieces of genetic material, Bcr-Abl setsoff the cascade of signals that tells the body to produce the

ancerous white blood cells that mark this form of leuke-

mia.

The following years saw more research on the role of Bcr-

Abl in CML and the simultaneous development of a new

lass of drugs that act differently from conventional che-

motherapy. These drugs were not cytotoxic (cell-killing);

nstead, they specically blocked the ability of the Bcr-Abl

gene to send the signals that drive abnormal blood cells to

divide and block out normal, healthy blood cells.

A retired train conductor read a story in his local newspaper

bout one of these new drugs, called Bcr-Abl inhibitors,

under study at the University of Oregon. He had been diag-

nosed with CML. He knew it was a very bad disease, with

median survival of three to six years, and with limited

reatment options.

He bravely volunteered to be the rst person to try the tr

ment. He survived, followed by a few other volunteer

the rst clinical study, then hundreds more in large clin

trials and thousands more in clinical practice.

Advances in research continue on Bcr-Abl, yielding e

improving outcomes for CML patients treated with Bcr-

inhibitors. These new treatments have shown that therap

developed based on a study of the biology of cancer c

can improve control of the disease and work with fe

side effects. They also provide inspiration for research

understanding of the core makeup of other cancers in

effort to match the success seen with these CML treatme

Learn more about Bcr-Abl inhibitors and other areas of

cer research by visiting the National Cancer Institute w

site (www.cancer.gov) and ClinicalTrials.gov. In addit

CML Earth (www.cmlearth.com) is a global, interac

social network for CML patients, caregivers, and pat

groups, sponsored by Novartis Oncology, and dedicate

connecting the CML community from around the worl

Researchers work to nd the new generation of medicine to treat chron

myeloid leukemia (CML).


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Visit our website at www.northtexasjournal.n

for local, state, regional, national and inte

national news community updates and more

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The North Texas Journal v24n25