The Teratology Society Thirty-Sixth Annual Meeting June 22-27, 1996

TERATOLOGY 53:5W31(1996)

THE TERATOLOGY SOCIETY

ANNUAL MEETING THI RTY-SIXTH

JUNE 22 - 27, 1996

AND

THE NEUROBEHAVIORAL TERATOLOGY SOCIETY

TWENTIETH ANNUAL MEETING JUNE 23 - 26, 1996

KEYSTONE RESORT KEYSTONE, COLORADO

Program, Abstracts

56 TERATOLOGY SOCIETY PROGRAM

JOSE F. CORDER0 Vice President

TERATOLOGY SOCIETY OFFICERS 1995-1996

KATHLEEN K. SULIK President

GEORGE P. DASTON Secretary (1995-1997)

PHILIP E. MIRKES Vice President-Elect

ELAINE Z. FRANCIS Treasurer (1995-1998)

PATRICIA M. RODIER(1993-1996) ROBERT J. KAVLOCK (1994-1997) WILLIAM SLIKKER, JR. (1995-1998) Council Members

Past-Presidents of the Society

J.WARKANY

J.G. WILSON

F.C.FRASER

M.M.NELSON

D.A. KARNOFSKY

L. W .MONIE

S.Q.CHOLAN

M.N.RUNNER

R. L . BRENT

T.H. SHEPARD

R.W.MILLER

J.LANGMAN

1960-1961

1961 - 1962

1962- 1 963

1963- 1964

1964-1965

1965-1 966

1965-1966

1966- 1967

1967- 1968

1968- 1969

1969-1970

1970- 197 1

A .PRUZANSKY

D.G.TRASLER

J.R.MILLER

E.M. JOHNSON

L. S. HURLEY

J.L.SEVER

E. V. PERRIN

A.R.BEAUDOIN

R.M.HOAR

C.R.SWINYARD

W.J.SCOTT, JR.

D.M.KOCHHAR

1971 -1972

1972-1973

1973-1 974

1974- 1975

1975-1976

1976- 1977

1977-1978

1978- 1979

1979-1980

1980-1981

1981-1982

1982- 1983

R.E. STAPLES

G.P.OAKLEY, JR.

L.B.HOLMES

A.G.HENDRICKX

C.T.GRABOWSK1

M. S.CHRISTIAN

E. F.ZIMMERMAN

C.A.KIMMEL

R.K.MILLER

M.BARR, JR.

J. W .HANSON

J.M.DESESS0

1983-1984

1984-1985

1985-1986

1986-1987

1987-1988

1988-1989

1989-1990

1990-199 1

1991 -1992

1992- 1993

1993-1994

1994-1 995

CAROL C. LEMIRE Executive Secretary Teratology Society

9650 Rockville Pike Bethesda, Maryland 20814 USA

TEL: (301) 571-1841 - FAX: (301) 571-1852 - Email: [email protected]

TERATOLOGY SOCIETY PROGRAM 57

COMMITTEES OF THE TERATOLOGY SOCIETY

1995 - 1996

(Date indicates year of expiration of term or office)

CONSTITUTION AND BYLAWS COMMITTEE

Bryan D. Hardin (1 996)

George E. Dearlove ( 1997) David A. Beckman (1998) Patricia M. Rodier (Council Liaison)

T: (202) 205-8556 F: (202) 260-4464

EDUCATION COMMITTEE

Thomas B. Knudsen, Chair ( 1996)

Patrick J. Wier, Secretary ( 1997) Carmella I. Tellone (1997) Craig Harris Melissa S. Tassinari Martha M. Werler Jose F. Cordero (Council Liaison)

T: (215) 955-7843; F: (215) 923-8308

FINANCE COMMITTEE

Elaine Z. Francis, Chair

Ronald P. Jensh Jose F. Cordero

T: (202) 260-03 14 F: (202) 260-6932

INTL FEDERATION OF TERATOLOGY SOCIETIES

Carole A. Kimmel Mason Barr, Jr. Robert J. Kavlock (Council Liaison)

American Society of Human Genetics John M. Graham, Jr.

Committee of Regional Networks for Genetics (CORN) Frank Greenberg

Council of Medical Genetics Organization James W. Hanson

Healthy Mothers, Healthy Babies John L. Sever

MARTA Mary Giknis

MTA Judy Hencks

Society of Environmental Toxicology & Chemistry Robert P. Beliles

Society of Toxicology Bernard A. Schwetz

T: (310) 855-2211 F: (213) 651-5381

T: (202) 319-7227 FAX: (202) 319-7301

T: (301) 496-5099 F: (301)402-2085

T (202) 884-4132 F: (202) 884-3051

T (908) 522-9580

T: (313) 996-7127

T: (202) 260-3018 F: 202-260-3803

T: (501) 543-7517 F: (501) 543-7576

MEMBERSHIP COMMITTEE

Ronald D. Hood, Chair ( 1996)

Harpal S. Buttar (1 997) Karen Filkins ( 1998) George P. Daston (Council Liaison)

T: (205) 348-1817 F: (205) 348-1786

NOMINATIONS AND ELECTIONS COMMITTEE LIAISON REPRESENTATIVES

AAALAC B.R. Sonawane

American Academy of Pediatrics Robert L. Brent

American College of Toxicology Mildred S. Christian

T: (202) 260-1495 F: (202) 260-8719

T: (302) 651-6880 F (302) 651-6888

T: (215) 443-8710 F: (215) 672-3619

Frank Welsch, Chair (1996)

John M. Rogers ( 1996) Richard G. Skalko (1996) David W. McCandless John M. DeSesso William Slikker, Jr. (Council Liaison)

T: (919) 558-1311 F: (919) 558-1300


PROGRAM COMMITTEE STUDENT AFFAIRS COMMITTEE

Jose F. Cordero, Chair

Thomas B. Knudsen (Education Course) John M. Rogers (Student Awards) Joseph M. Lary

T: (404) 639-8200 F: (404) 639-8626

PUBLIC AFFAIRS COMMITTEE

Jan M. Friedman, M.D., Ph.D. Chair (1998)

Calvin C. Willhite (1 996) Kenneth P. Chepenick ( 1996) Joseph J. Mitala (1996) John Harris ( 1996) Robert L. Clark (1997) Adolfo Correa-Villasenor (1997) Gerald C. Goeringer (1 997) E. Sidney Hunter (1997) Kathleen K. Sulik (ex officio)

T: (604) 875-3489 F: (604) 875-3490

PUBLICATIONS COMMITTEE

Richard G. Skalko, Chair (1997)

Charle V. Vorhees (1999)

Section Editors Jane Adams (1 996) Kenneth L. Jones (1 997) William Slikker, Jr. ( 1997)

Jan M. Friedman (1997) Muin J. Khoury ( 1997) Lewis B. Holmes (1997) Deborah K. Hansen (1998)

Rudi Balling David D. Weaver Frank A. Walsh Ex Officio Members: Thomas W. Sadler, Editor-in-Chief (1997) Nigel A. Brown, Liaison European Teratology Society Mineo Yasuda, Liaison Japanese Teratology Society William F. Curtis, John Wiley Publications Kathleen K. Sulik, President Patricia M. Rodier (Council Liaison)

T (423) 929-6241 F: (423) 461-7040

Thomas E. Kwasigroch (2001)

Richard H. Finnell ( 1997)

Thomas M. Burbacher (2000)

John M. Rogers, Chair

Alan G. Fantel Robert M. Parker Trent D. Stephens Kit A. Keller (ad hoc) Dana Shuey (ad hoc) Jose F. Cordero (Council Liaison)

T (919) 541-5177 F: (919) 541-4017 (1996)

( 1997) (1998)

ACOG TERATOLOGY INTEREST GROUP COMMITTEE (AD HOC)

Michael F. Greene, Chair

John W. Larsen, Jr. Bernard A. Schwetz Anthony R. Scialli Thomas H. Shepard James R. Woods

T: (617) 732-5452 F: (617) 732-4795

EXHIBITOR LIAISON COMMITTEE (AD HOC)

William Dean, Chair

Richard E. Butcher Charles H. Frith Robert J. Kavlock Loretta Lawrence Lee Varden George P. Daston (Council Liaison)

T: (501) 397-2540; F: (501) 397-2002

FINANCIAL ADVISORY COMMITTEE (AD HOC)

Richard K. Miller, Co-Chair

Robert E. Staples Lewis B. Holmes Mildred S. Christian James L. Schardein Elaine Z. Francis (ex officio) Kathleen K. Sulik (ex officio) Jose F. Cordero (ex officio) Philip E. Mirkes (ex officio)

T: (716) 275-2520 F: (716) 244-2209


GRANT FUNDING COMMITTEE (AD HOC)

Philip E. Mirkes, Chair

James W. Hanson Craig Harris Lewis B. Holmes Mont R. Juchau Gary L. Kimmel Thomas B. Knudsen Gary C. Schoenwolf Thomas W. Sadler Kathleen K. Sulik

T: (206) 543-3373 F: (206) 543-3184

HISTORY COMMITTEE (AD HOC)

Paul Peters, Chair T: 31 30 742146 F: 31 30 291365 Charlotte Ferencz

Kenneth L. Jones Pia B. Lindstrom Joan L. Randall Daniel M. Sheehan Waheed H. Siddiqui Jamail Sin& William Slikker, Jr. (Council Liaison)

TERATOLOGY INFORMATION SERVICES COMMITTEE (AD HOC)

Jane O’Brien, Chair

Jaime L. Frias Paul W. J. Peters Kenneth L. Jones Gideon Koren Richard K. Miller

T: (617) 787-5960 F: (617) 787-9019

TERMINOLOGY COMMITTEE (AD HOC) LEGISLATIVE AFFAIRS COMMITTEE (AD HOC)

Gary L. Kimmel, Ghair

Richard A. Byrd Andrew G. Hendrickx Jennifer Seed Ernest F. Zimmerman John M. DeSesso (ex officio) Kathleen K. Sulik (ex officio) Robert J. Kavlock (Council Liaison)

T: (202) 260-5978 F: (202) 260-8719

NEWSLETTER EDITOR (AD HOC)

Carole A. Kimmel T: (202) 260-7331 F: (202) 260-8719

RECRUITMENT COMMITTEE (AD HOC)

Alan M. Hoberman, Chair T: (215) 443-8710 F: (215) 443-8587

SOCIETAL PARTICIPATION COMMITTEE (AD HOC)

L. David Wise, Chair

Howard M. Solomon Jennifer Seed Rochelle W. Tyl Mark D. Nemec Pia B. Lindstrom

T: (215) 652-6974 F: (215) 652-3423

David W. McCandless, Chair

David 0. Clarke Barbara F. Hales Joseph F. Holson

T: (708) 578-3210 F: (708) 578-3253


PRESIDENT'S CIRCLE MEMBERS - 1996'

ARGUS RESEARCH LABORATORIES, INC.

GLAXO WELLCOME INC.

HUNTINGDON LIFE SCIENCES PFIZER CENTRAL RESEARCH

SANOFI WINTHROP, INC. SMITHKLINE BEECHAM PHARMACEUTICALS SPRINGBORN LABORATORIES INC. VALENT U.S.A COPRPORATION WIL RESEARCH LABORATORIES, INC.

THE COCA-COLA COMPANY

HOFFMANN-LA ROCHE, N C .

RHONE-POULENC RORER

SUSTAINING MEMBERS - 1996'

ABBOTT LABORATORIES AMERICAN PETROLEUM INSTITUTE

CHEVRON COWORATION DOW CORNING CORPORATION DUPONT DE NEMOURS & COMPANY EXXON BIOMEDICAL SCIENCES, INC. HOECHST CELANESE MITRETEK SYSTEMS THE PROCTER & GAMBLE COMPANY R.W. JOHNSON, PRI PHARMACIA AND UPJOHN MC.

BRISTOL-MYERS SQUIBB

WARNER-LAMBERT COMPANY

Due to the early printing deadlines in 1995, the organization below was not included in last year's program as a Sustaining Member, 1995.

LILLY RESEARCH LABS A Division of Eli Lilly & Company

* Listing as of March 1996


1996 ANNUAL MEETING

The Teratology Society is pleased to acknowledge contributions from the following organizations to support the 1996 Annual Meeting. Additional contributors to the 1996 Annual Meeting will be listed in an insert to this year’s program and in the 1997 Annual Meeting Program, which will appear in the May 1997 issue of TERATOLOGY.

AMERICAN INDUSTRIAL HEALTH COUNCIL CHEVRON CORPORATION ELI LILLY AND COMPANY G. D. SEARLE & COMPANY

MARCH OF DIMES BIRTH DEFECTS FOUNDATION MIDDLE ATLANTIC REPRODUCTION & TERATOLOGY ASSOCIATION JOHN WILEY & SONS, INC.

HOFFMANN-LA ROCHE, INC.

1995 ANNUAL MEETING

The Teratology Society is pleased to acknowledge contributions from the following companies to support the 1995 Annual Meeting. Due to the early printing deadlines in 1995, the organizations below were not included in last year’s program.

AMERICAN INDUSTRIAL HEALTH COUNCIL EASTMAN KODAK COMPANY ELI LILLY AND COMPANY M.A.R.T.A. SANDOZ RESEARCH INSTITUTE WEST COAST TERATOLOGY SOCIETY WYETH-AYERST LABORATORIES


11100 - 5:OO

1:OO - 4:OO

1:OO - 6:OO

1:OO - 1:05

1:05 - 1:15

1115 - 2100

2:OO - 2:45

2145 - 3:30

3:30 - 3145

3:45 - 4130

4:30 - 5 ~ 1 5

5:15 - 6:OO

7:OO - 9:30

36TH ANNUAL MEETING OF THE TERATOLOGY SOCIETY

PROGRAM

SATURDAY, JUNE 22, 1996

TERATOLOGY SOCIETY REGISTRATION - Red CloudShevano Foyer

COUNCIL IA - Boardroom

CONTINUING EDUCATION COURSE - Risk Assessment in Developmental Toxicology - Red Cloud Peak

WELCOME - Kathleen K. Sulik, Ph.D., President, Teratology Society

INTRODUCTION AND ORIENTATION Thomas B. Knudsen, Ph.D., Chairman, Education Committee

OVERVIEW OF RISK ASSESSMENT Carole A. Kimmel, Ph.D., National Center for Environmental Assessment, US EPA, Washington, DC

I. HAZARD IDENTIFICATION

HAZARD IDENTIFICATION: ANIMAL STUDIES Patrick J. Wier, Ph.D., SmithKline Beecham, Research & Development Division, King of Prussia, PA

HAZARD IDENTIFICATION IN HUMAN PREGNANCIES Lewis B. Holmes, M.D., Massachusetts General Hospital, Genetics & Teratology Unit, Boston, MA

COFFEE BREAK - Red Cloud Peak Foyer

11. DOSE-RESPONSE ANALYSIS

REFERENCE DOSE BY NOAEL Rochelle W. Tyl, Ph.D., Research Triangle Institute, Center of Life Science & Toxicology, Research Triangle Park, NC

BENCHMARK DOSE APPROACH Elaine M. Faustman, PLD., University of Washington, Dept of Environmental Health, Seattle, WA

BIOLOGICALLY-BASED MODELS Christopher S. Lau, Ph.D., US EPA, Health Effects Research Laboratory, Research Triangle Park, NC

WELCOME BUFFET - Mountain House


SUNDAY, JUNE 23,1996

8:OO - 4:30

8:OO - 8115

8:OO - 12:OO

9:OO - 1:OO

8 ~ 1 5 - 11~45

8 ~ 1 5 - 9100

9:OO - 9:45

9:45 - lor15

10~15 - 11:OO

11:OO - 11:45

11 :45

6:OO - 8:OO

7:OO - 8:OO

7~30 - 8:OO 7~30 - 5:OO 9:15 - 5:OO

8:OO - 8 ~ 1 5

TERATOLOGY SOCIETY REGISTRATION - Red Cloud/Shavano Foyer

COURSE CONTINENTAL BREAKFAST - Red CloudShavano Foyer

COMMITTEE MEETINGS - Sunburst, Sundrift, Windwood, Silverhawk, Silverwood, Foxfire

COUNCIL IB - Boardroom

CONTINUING EDUCATION COURSE (continued) - Red Cloud Peak

111. EXPOSURE ASSESSMENT

NON-OCCUPATIONAL EXPOSURE ASSESSMENT Thomas Osimitz, Ph.D., D.A.B.T., Safety Assessment and Regulatory Affairs, S.C. Johnson and Sons, Racine, WI

OCCUPATIONAL EXPOSURE ASSESSMENT Curt Lunchick, Jellinek, Schwartz, and Connolly, Inc., Arlington, VA

COFFEE BREAK - Red Cloud Peak Foyer

IV. RISK CHARACTERIZATION

RISK ESTIMATION IN RISK CHARACTERIZATION Jack Moore, D.V.M., Institute for Evaluating Health Risk, Washington, DC

RISK COMMUNICATION Carmella I. Tellone, Ph.D., Valent USA, Walnut Creek, CA

ADJOURNMENT

PRESIDENT'S RECEPTIONKASH BAR - Low Plazmdgewater

STUDENT MIXER - Lakeside Suite Presentation: Dr. Robert Parker, Study Director and Senior Scientist, TSI Corp/Argus ResearchLaboratones, Horsham, PA "DO'S AND DON'TS FOR EFFECTIVE PLATFORM PRESENTATIONS"

MONDAY, JUNE 24, 1996

CONTINENTAL BREAKFAST - Shavano Foyer TERATOLOGY SOCIETY REGISTRATION - Red CloudShavano Foyer EXHIBITORS - Torrey's 1-4

WELCOME AND INTRODUCTION - Red CloudlShavano Dr. Kathleen Sulk, President, Teratology Society


Monday, June 24, 1996

8 ~ 1 5 - 9:OO WARKANY LECTURE - Red Cloud/Shavano "RUBELLA TO RETINOIDS, RODENTS, RISKS AND REACTIONS" Dr. William Webster, Sidney, Australia

9:OO - 12:OO WILEY LISS SYMPOSIUM - BRAIN DEVELOPMENT - Red CloudlShavano Chair: Patricia M. Rodier, Ph.D., Senior Scientist, University of Rochester Medical Center, Department of Obstetrics and Gynecology, Rochester, NY

9:OO - 9:40 RETINOIDS, HOMEOBOX GENES, AND HINDBRAIN OF THE DEVELOPING EMBRYO Lorraine J. Gudas, Ph.D., Dept of Pharmacology, Cornell Medical Center, New York, NY

9:40 - 1O:OO CRANIAL NERVE DYSFUNCTION ASSOCIATED WITH AUTISM Marilyn T. Miller, M.D., Dept of Ophthalmology, University of Illinois, Chicago, IL

1O:OO - 10~15 COFFEE BREAK - Torrey's 1-4

lor15 - lor40 SHIFTS OF ATTENTION IN AUTISM Susan E. Bryson, Ph.D., Dept of Psychology, York University, Toronto, ON, Canada

ONTOGENY OF COGNITIVE BEHAVIOR Jerry W. Rudy, Ph.D., Dept of Psychology, University of Colorado, Boulder, CO

FRONTAL LOBE DYSFUNCTION IN TREATED PKU Adele Diamond, Ph.D., Dept of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA

10:40 - 11:20

11:20 - 12:oo

12:OO - 1:30

1:30 - 5:OO

1130 - 2:OO

2:OO - 2:15

2115 - 2:30

Lunch Break

CONCURRENT SESSION I - Red Cloud Peak "MOLECULAR MECHANISMS OF ABNORMAL DEVELOPMENT" Co-Chairs: Dr. Barbara Hales & Dr. George Daston

KEYNOTE LECTURER - John Cidlowski, Ph.D., Head of Molecular Endocrinology Group, Lab of Cellular & Molecular Pharmacology, NIEHS/NIH, Research Triangle Park, NC APOPTOSIS: BIOCHEMISTRY AND MOLECULAR BIOLOGY OF PROGRAMMED CELL DEATH

1. THE GLUTATHIONE SYNTHESIS INHIBITOR, BUTHIONINE SULPHOXIMINE (BSO), INDUCES THE DNA BINDING ACTIVITY OF THE TRANSCRIPTION FACTOR ACTIVATOR

MANNER - Ozolins*, T.R.S. and B.F. Hales. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

PROTEIN-1 (AP-1) IN THE RAT CONCEPTUS IN A GLUTATHIONE (GSH)-INDEPENDENT

2. MOLECULAR BASIS OF DIFFERENTIAL SUSCEPTIBILITY TO TERATOGENIC TREATMENT IN NORMAL AND P53-NULL MUTANT MICE - Knudsen, T.B., M.M. Ibrahim*, J.A. Wubah*, and D. Nguyen*. Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania.


Monday, June 24,1996 - Continued

2:30 - 2 ~ 4 5 3. EXPRESSION OF BCL-2 AND BCL-2 FAMILY MEMBERS IN EARLY POSTIMPLANTATION MOUSE EMBRYOS - Mikes, P.E., K. Wilson, M. Set0 and M.L. Cunningham. Birth Defects Research Laboratory, Division of Congenital Defects, Departments of Pediatrics and Biological Structure, University of Washington, Seattle, Washington.

2 ~ 4 5 - 3:OO

3:OO - 3:15

3 ~ 1 5 - 3:30

3:30 - 3:45

3:45 - 4:OO

4:OO - 4115

4:15 - 4:30

4:30 - 4:45

4:45 - 5:OO

2:OO - 5:OO

2:OO - 2:30

4. ROLE OF P53 AND P53-DEPENDENT APOPTOSIS IN THE LIMB MALFORMATIONS INDUCED BY IN VITRO EXPOSURE TO AN ACTIVATED ANALOG OF CYCLOPHOSPHAMIDE (CPA) - Moallem*, S.A. and B.F. Hales. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

5. DEVELOPMENTAL TOXICITY INDUCED BY ANTISENSE INHIBITION OF CATALASE IN CULTURED MOUSE EMBRYOS - Bauman, J.W., K.M. Denno, B.B. Taylor, and T.W. Sadler. UNC Birth Defects Center, Department of Cell Biology & Anatomy, University of North Carolina, Chapel Hill, NC.

COFFEE BREAK - Torrey's 1-4

6. ANTISENSE DISRUPTION OF THE MSX GENES REVEALS FUNCTIONAL ROLES CRUCIAL TO THE DEVELOPMENT OF CRANIOFACIAL, EYE AND AXIAL STRUCTURES - Foerst Po-*, L., and T.W. Sadler, Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, NC.

I . PAX 6, A BIOMARKER OF P53-DEPENDENT EVENTS LEADING TO TERATOGEN- INDUCED EYE DEFECTS - Wubah*, J.A. and T.B. Knudsen. Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania.

8. LUMBAR RIBS ASSOCIATED WITH POSTERIORIZATION OF HOX a10 EXPRESSION IN SALICYLATE-TREATED MOUSE EMBRYOS - Daston, G.P., and G.J. Overmann*. Miami Valley Labs., Procter & Gamble, Cincinnati, Ohio.

9. NOTCH SIGNALING IS CRUCIAL FOR EMBRYO DEVELOPMENT IN MOUSE - Gao, X., M. Maguire*, L. Shen*, G. Weinmaster*, and T. Gridley'. The Jackson Laboratory, Bar Harbor, Maine.

10. QUANTITATIVE ANALYSIS OF AH RECEPTOR, A N T , AND GR mRNA IN EMBRYONIC MOUSE PALATE - Abbott, B.D., R.D. White*, J. Schmidl, R.W. Setzer*, J.G. Brown*, C. Wood*, and G. Held*. NHEERL, US EPA, Research Triangle Park, North Carolina.

11. ANTISENSE OLIGONUCLEOTIDES AGAINST HSP70-1 AND 70-3 INCREASE MOUSE EMBRYONIC SENSITIVITY TO ARSENITE-INDUCED DYSMORPHOGENESIS IN VITRO - Hunter, E.S. and D. Dix*, Reproductive Toxicology Division, NHEERL, US EPA, Research Triangle Park, NC.

CONCURRENT SESSION I1 - Shavano Peak "CLINICAL TERATOLOGY" Co-Chairs: Dr. Mason Barr, Jr. & Dr. Lewis Holmes

KEYNOTE LECTURER - John M. Opitz, M.D., Director & Professor, Foundation for Developmental and Medical Genetics, Helena, MT THE FUTURE, OF MORPHOLOGY


Monday, June 24, 1996 - Continued

2:30 - 2:45 12. VALPROIC ACID TREATMENT IN RATS REPRODUCES THE CEREBELLAR ANOMALIES ASSOCIATED WITH AUTISM - Ingram*, J.L., V.J. Croog*, B. Tisdale*, and P.M. Rodier. Departments of Environmental Medicine and Obstetrics and Gynecology, University of Rocllester, Rochester, NY.

2:45 - 3:OO 13. MOBIUS SYNDROME: A POSSIBLE TERATOGENIC MECHANISM -Shepard, T.H., and R.J. Lemire. Central Laboratory for Human Embryology, Division of Congenital Defects, Department of Pediatrics, University of Washington, Seattle, Washington.

3:OO - 3:15 14. PULMOMEGALY SECONDARY TO LARYNGEAL ATRESIA WITHOUT ACCELERATED LUNG MATURATION - Bar, M. Teratology Unit, Departments of Pediatrics, Pathology and Obstetrics, University of Michigan, Ann Arbor, MI.

3115 - 3:30 COFFEE BREAK - Torrey's 1-4

3130 - 3:45 15. EXTENSIVE DIGITAL HYPOPLASIA WITH MINIMAL CONSTRICTION RINGS: SUPPORT FOR VASCULAR DISRUPTION AS THE PRIMARY PATHOGENETIC MECHANISM OF THE AMNIOTIC BAND DISRUPTION SEQUENCE - Seaver*, L.H. (introduced by H.E. Hoyme), Greenwood Genetic Center, Greenwood, SC.

3:45 - 4:OO 16. ANTICONVULSANT TERATOGENESIS: EFFECTS ON DIGITS ARE COMMON, BUT SUBTLE - Lu*, M.C.K., M.D. Sammel*, R.H. Cleveland*, L. Ryan, L.B. Holmes, Massachusetts General Hospital and Harvard School of Public Health, Boston, MA.

4:OO - 4:15 17. SUBTLE EFFECTS OF ANTIEPILEPTIC DRUGS ON TOOTH DEVELOPMENT - Orup*, H.I. Jr., D.A. Keith', and L. B. Holmes. Harvard School of Dental Medicine, and Genetics and Teratology Unit, Massachusetts General Hospital, Boston, MA.

4:15 - 4:30 18. LUMPING AND SPLITTING WITHIN THE CEREBRO-OCULO-FACIAL-SKELETAL (COFS) SPECTRUM OF DISORDERS - Graham, J.M., Jr., E. H. Zackai, R.A. Lewis, W.B. Dobyns. Medical Genetics Birth Defects Center, Division of Dysmorphology/Clinical Genetics, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA. Children's Hospital of Philadelphia, Clinical Genetics Center, Philadelphia, PA. Departments of Ophthalmology, Medicine, Pediatrics, and Genetics, Baylor College of Medicine, Houston, TX. Division of Pediatric Neurology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN.

4130 - 4 ~ 4 5

4:45 - 500

7:OO - 1O:OO

19. STUDY OF PLACENTA OF CHILDREN BORN WITH CONGENITAL MALFORMATIONS - Stoll*, C., Y. Alembik, B. Dott, and M.P. Roth. Institut de Puericulture, Centre Hospitalo-Universitaire, Strasbourg, France.

20. BenacerraP, L.B. Holmes. Pediatrics, Harvard Medical School, Boston, MA.

BBQ/BARN DANCE - Keystone Stables

IS THERE A "DIABETIC EMBRYOPATHY"? - Greene, M.F., K. Hirt Armon*, A. Lin*, B.R. Departments of Obstetrics, Gynecology and Reproductive Biology and


8:OO - l:oo 7~45 - 8:15 9 ~ 3 0 - 1 1 :30

8:30 - 12~15

8:30 - 8:45

8:45 - 9:30

9130 - 10:15

10~15 - 10:45

10:45 - 11:30

11~30 - 12115

12~15 - 600

1:OO - 3:OO

3:OO - 6:OO

6:OO - 7:30

7:30 - lot30 7:30 - 9:OO 9:OO - 10130

TUESDAY, JUNE 25, 1996

TERATOLOGY SOCIETY REGISTRATION - Red CloudShavano Foyer CONTINENTAL BREAKFAST - Shavano Foyer EXHIBITORS - Torrey's 1-4

MARCH OF DIMES SYMPOSIUM - Red Cloud/Shavano "MOLECULAR TERATOLOGY"

INTRODUCTION Thomas W. Sadler, Ph.D., Professor, Director UNC Birth Defects Center, University of North Carolina, Dept Cell Biology & Anatomy, Chapel Hill, NC

THE ROLE OF NOVEL HOMEOBOX GENES IN PITUITARY AND FOREBRAIN DEVELOPMENT Kathleen A. Mahon, Ph.D., Head, Unit on Developmental Gene Regulation, Laboratov of Mammalian Genes and Development, Natl Institute of Child Health & Human Development, NIH, Bethesda, MD

ROLE OF SUB-CELLULAR LOCALIZATION OF mRNAs IN NEURONAL DEVELOPMENT James H. Eberwine, Ph.D., Associate Professor of Pharmacology & Psychiatry, Univeristy of Pennsylvania, Philadelphia, PA


INSERTIONAL MUTAGENESIS & REVERSAL OF LEFT-RIGHT POLARITY IN TRANSGENIC MICE Paul Overbeek, Ph.D., Associate Professor, Department of Cell Biology, Baylor College of Medicine, Houston, TX

INDUCTION GENE TRAPPING IN ES CELLS: A NOVEL APPROACH TO IDENTIFY LIGAND- INDUCED TARGET GENES Wolfgang Wurst, Ph.D., GSF Research Center for Environment and Health, Institution for Mammalian Genetics, Munich, Germany

FREE TIME

POSTER SET UP - Red Cloud/Shavano

POSTER PREVIEW (Unattended) - Red CloudlShavano

TERATOLOGY SOCIETY BUSINESS MEETING - Crestone 1-2

POSTER SESSION - Red Cloud/Shavano Even Number Posters - Attended Odd Number Posters - Attended

10:30 Posters Removed


WEDNESDAY, JUNE 26,1995

7:30 - 8:OO 7:30 - 4:30 9:30 - 5100

8:OO - 1O:OO

8:OO - 8:30

8:30 - 8:45

8~45 - 9100

9:OO - 9:15

9:15 - 9:30

9:30 - 9:45

9:45 - 1o:oo

1O:OO - 10:15

10:15 - 11:OO


CONCURRENT SESSION 111 A - Red Cloud Peak "MECHANISMS OF ABNORMAL DEVELOPMENT I" Co-Chairs: Dr. Robert Seegmiller & Dr. B.K. Nelson

KEYNOTE LECTURER - Carl L. Keen, Ph.D., Professor of Nutrition and Internal Medicine, University of California, Davis, CA MATERNAL NUTRITIONAL STATUS; A KEY MODULATOR OF EMBRYONIC AND FETAL DEVELOPMENT

2 1. MATERNAL EXPOSURE TO 2-ETHYLHEXANOIC ACID (EHXA), 2-ETHYLHEXANOL (EHXO), AND VALPROIC ACID (VPA) RESULTS IN ALTERATIONS IN MATERNAL AND EMBRYONIC ZINC STATUS - Taubeneck,M.W., J.Y. Uriu-Hare, J.F. Commisso*, A.T. Borschers*, L.M. Bui*, W. Faber and C.L. Keen. University of California, Davis, CA and The Eastman Kodak Corporation, Rochester, NY.

22. THE EFFECTS OF CARNITINE ON THE IN VITRO AND IN VIVO DEVELOPMENTAL TOXICITY OF VALPROIC ACID - Andrews, J.E., M. Ebron-McCoy*, and R.J. Kavlock. Reproductive Toxicology Division, NHEERL, US EPA, Research Triangle Park, NC.

23. NUCLEOTIDE-MEDIATED MITIGATION OF 5-FU-INDUCED TOXICITY IN SYNCHRONIZED MELC - Elstein*, K.H., M.L. Mole*, R.W. Setzer*, R.M. Zucker, R.J. Kavlock, J.M. Rogers and C. Lau*. US EPA/NHEERL/RTD, Research Triangle Park, NC.

24. THE EFFECTS OF 2-METHOXYETHANOL ON DEVELOPMENTAL STAGE-AND CELL TYPE-SPECIFIC PHYSIOLOGICAL CELL DEATH IN CD-1 MOUSE EMBRYOS - Ambroso, J.L., Stedman, D.B., Elswick*, B.A. and F. Welsch. Chemical Industry Institute of Toxicology, Research Triangle Park, NC.

25. EXAMINATION OF THE ROLE OF METHIONINE SYNTHASE AND METHYLATION IN NEURAL TUBE DEFECTS IN VITRO - Hansen, D.K., S.L. Dial*, and T.F. Grafton*. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas.

26. GENE-ENVIRONMENT INTERACTIONS IN CHOLESTEROL DEFICIENCY-BASED MALFORMATIONS - Lanoue*, L., D.B. Dehart, S. Tint, N. Maeda, and K.K. S u l k Departments of Cell Biology and Anatomy and Pathology, University of North Carolina, Chapel Hill, NC, and Veteran's Affairs Medical Center, East Orange, NJ.


CONCURRENT SESSION 111 B - Red Cloud Peak "EMBRYO IMAGING TECHNIQUES" Chair: Dr. John Rogers

TERATOLOGY SOCIETY PROGRAM 69 Wednesday, June 26,1996 - Continued

10:15 - 10~30 27. ANALYSIS OF RODENT EMBRYO IMAGES OBTAINED USING A LASER SCANNING CONFOCAL MICROSCOPE (LSCM); PROBLEMS AND SOLUTIONS - Branham; W.S., A.R. Haas*, J.F. Meehan, C. Pauken*, D.M. Sheehan, and J.F. Young. Division of Reproductive and Developmental Toxicology and R.O. W. Sciences Inc., National Center for Toxicological Research, Jefferson, Arkansas.

28. ELECTRONIC IMAGING OF THE DEVELOPING RODENT EMBRYO AND FETUS IS THE BEGINNING, NOT AN END - Young, J.F., W.S. Branham, A.R. Haas*, J.F. Meehan*, A.R. Warbritton*, and D.M. Sheehan. Division of Reproductive and Developmental Toxicology, R.O.W. Sciences Inc., and Pathology Associates International, National Center for Toxicological Research, Jefferson, Arkansas.

10:30 - 10:45

10~45 - 11:OO

8:30 - 1O:OO

8 ~ 3 0 - 9:OO

9:OO - 9~15

9115 - 9 ~ 3 0

9 ~ 3 0 - 9:45

9:45 - 1o:oo

1O:OO - 10:15

10~15 - 11:OO

10115 - 10:30

29. TERATOLOGICAL APPLICATIONS OF CONFOCAL LASER SCANNING MICROSCOPY - Zucker, R.M., and J. M. Rogers, National Health and Environmental Effects Research Laboratory, US E P A, Research Triangle Park, NC.

CONCURRENT SESSION IV A - Shavano Peak "RETINOIDS" Chair: Dr. Andrew Hendrickx

KEYNOTE LECTURER - Richard K. Miller, Ph.D., Univ Rochester School of Medicine and Dentistry, Dept of Obstetrics & Gynecology, Rochester, NY THE PLACENTA: THE INTERPHASE FOR NORMAL AND ABNORMAL DEVELOPMENT

30. SPECIES-SPECIFIC METABOLISM OF AN RXR PREFERENTIAL RETINOID PREDICTS TERATOGENIC LIABILITY - Eckhoff, C., D. Lucas*, and G. Rush*. Hoftinann-La Roche Inc., Nutley, NJ.

3 1. PATHOGENESIS OF 13-CIS RETINOIC ACID-INDUCED CRANIOFACIAL AND HINDBRAIN MALFORMATIONS IN THE LONG-TAILED MONKEY (UACACA FASCICULARIS) - Makori*, N., P.E. Peterson, H. Hummler, T.N. Blankenship*, G.E. Owiti*, and A.G. Hendrickx. California Regional Primate Research Center, University of California, Davis and F. Hoffmann-La Roche, Ltd., Basel, Switzerland.

32.

Moore, C.A., and J. Mulinare. Birth Defects and Genetic Diseases Branch, CDC, Atlanta, GA.

DO VITAMIN A SUPPLEMENTS IN EARLY PREGNANCY INCREASE THE RISK OF BIRTH DEFECTS IN THE OFFSPRING? A POPULATION-BASED CASE-CONTROL STUDY - Khoury*, M.J.,

33. HIGH VITAMIN A INTAKE AND RISK FOR MAJOR ANOMALIES INVOLVING STRUCTURES WITH AN EMBRYOLOGICAL CRANIAL NEURAL CREST CELL COMPONENT - Lammer, E.J., Shaw, G.M., Wasserman, C.R. and Block, G. Children's Hospital, Oakland, CA; CA Birth Defects Monitoring Program, Emeryville; University of California, Berkeley.


CONCURRENT SESSION IV B - Shavano Peak "PLACENTAL FUNCTIONS AND IMPLANTATION" Chair: Dr. Andrew Hendrickx

34. EXPOSURE TO ZIDOVUDINE (AZT) IN THE PERFUSED HUMAN PLACENTA: A PHARMACOKMETIC AND TOXICITY ASSESSMENT - Plessinger, M.A., Boal*, J.H. vandenReydt*, C., and Miller, R.K. Departments of Obstetrics and Gynecology and of Environmental Medicine, University of Rochester, Rochester, NY.


Wednesday, June 26, 1996 - Continued

10:30 - 10~45 35. DIAMIDE-INDUCED THIOL OXIDATION IMPAIRS VISCERAL YOLK SAC HISTIOTROPHIC FUNCTIONS IN THE POST-IMPLANTATION RAT CONCEPTUS IN VITRO - Larsen., S.J.V., Ambroso, J.L., and C. Harris. Toxicology Program, Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, MI.

10~45 - 11:OO

11:OO - 12:30

12~30 - 3:OO

12~30 - 1:OO

1:OO - 1 ~ 1 5

1:15 - 1130

1 ~ 3 0 - 1:45

1:45 - 2:OO

2:OO - 2 ~ 1 5

2115 - 2:30

2:30 - 2145

36. GENETIC ASSESSMENT OF ADENOSINE DEAMINASE IN THE DECIDWM OF MICE - Blackburn, M.R., and R.E. Kellems*. Department of Biochemistry, Baylor College of Medicine, Houston, TX.

LUNCH BREAK

CONCURRENT SESSION V A - Red Cloud Peak "EPIDEMIOLOGY" Co-Chairs: Dr. Muin J. Khoury & Dr. Adolfo Correa-Villaseflor

KEYNOTE LECTURER - Godfrey P. Oakley, Jr., M.D., MSPH, Director, Division of Birth Defects & Development, National Center for Environmental Health, CDC, Atlanta, GA FINDING CAUSES OF BIRTH DEFECTS IN THE 21ST CENTURY

37. DESERT STORM SEQUELAE: ARE GULF WARVETERANS FATHERING AN INCREASED INCIDENCE OF CHILDREN WITH CONGENITAL MALFORMATIONS? - Brent, R.L., and D.A. Beckman. Department of Pediatrics, Jefferson Medical College, Philadelphia, PA and Division of Developmental Biology, A.I. duPont Institute, Wilmington, DE.

38. VARIATION IN EPIDEMIOLOGIC CHARACTERISTICS FOR SUBGROUPS OF MEMBRANOUS VENTRICULAR SEPTAL DEFECTS - Correa-Villaseflor, A., C. Ferencz, C. Loffredo, P.D. Wilson*, and the Baltimore-Washington Infant Study Group, University of Maryland, Baltimore, MD.

39. THE EPIDEMIOLOGY OF HIRSCHSPRUNG DISEASE IN A LARGE MULTIRACIAL POPULATION - Torfs, C.P. California Birth Defects Monitoring Program, Emeryville, CA.

40. EPIDEMIOLOGY OF OROFACIAL CLEFTS: DIFFERENCES IN RATES BETWEEN POPULATIONS - Robert, E., KallBn, B., and Harris, J.A. Institut Europeen des Genomutations, Lyon, France, Tornblad Institute, Lund, Sweden and California Birth Defects Monitoring Program, Emeryville, CA.

4 1. DEVELOPMENTAL EVALUATION OF SCHOOL AGE CHILDREN WHO WERE BORN TO DIABETIC MOTHERS, IN COMPARISON TO CHILDREN WHO WERE BORN TO NON DIABETIC MOTHERS - Ratzon, N., Omoy*, A., Greenbaum, C., Peretz, A. & Dulizky, M. Laboratory of Teratology, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

42. CONTRIBUTION OF BIRTH DEFECTS AND LOW BIRTH WEIGHT TO MENTAL

Olney*, M. Yeargin-Allsopp*, M.J. Khoury, and P. DecouflC*. Division of Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.

43. THE EFFECTS OF OCCUPATIONAL EXPOSURE OF FEMALE NURSES TO

Zhao*, S.F., X.C. Zhang*, Q.F. Wang* and Y.S. Bao* (Introduced by D.M. Kochhar). Department of Occupational Health, Beijing Medical University, Beijing, China.

RETARDATION AMONG 10-YEAR-OLD CHILDREN; A POPULATION STUDY - L w , J.M., R.S.

ANTINEOPLASTIC DRUGS ON PREGNANCY OUTCOME AND EMBRYONIC DEVELOPMENT -



2145 - 3:OO

3100 - 3115

3:15 - 4:30

3:15 - 3:30

3:30 - 3:45

3145 - 4100

4:OO - 4 ~ 1 5

4:15 - 4:30

1:OO - 4 1 5

1:OO - 1:30

1:30 - 1:45

1:45 - 2:OO

2:OO - 2 ~ 1 5

44. INDUCTION OF LABOR IN PREGNANCIES COMPLICATED BY FETAL

DEMISE - Valley*, M.T., Hager*, D., Rayburn, W.F., Carey*, J.C. Department of Obstetrics and Gynecology, University of Oklahoma, Oklahoma City, OK.

MALFORMATIONS; A COMPARISON WITH PREGNANCIES HAVING A PRE-EXISTING FETAL


CONCURRENT SESSION VB - Red Cloud Peak LIMB DEVELOPMENT Dr. William Scott

45. Bateson. California Birth Defects Monitoring Program, Emeryville, CA.

46. THALIDOMIDE AS AN IGF-I ANTAGONIST - Stephens, T.D., C.J.W. Bunde*, andD.M. Smith. Department of Biological Sciences, Idaho State University, Pocatello, ID (TS, CB) and Department of Genetics, Harvard Medical School, Boston, MA (DS).

LATERALITY AND LIMB REDUCTION DEFECTS - Tolarova, M.M., J.A. Hams and T.F.

47. DISSOCIATION OF SONIC HEDGEHOG FROM ZPA IN THE MOUSE FORELIMB BUD - Bell, S.M., Schreiner, C.M. and Scott, W.J. Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, OH.

48. W.J. Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati, OH.

49. THE MOLECULAR BASIS OF ECTRODACTYLY - Seto*, M.L., M.E. Nunes*, and M.L. Cunningham. Birth Defects Research Laboratory, Division of Congenital DefectdCraniofacial Program, Department of Pediatrics, University of Washington, Seattle, WA.

IS FGF-8 REQUIRED FOR PROXIMALIDISTAL LIMB OUTGROWTH? -Bell, S.M., and Scott,

CONCURRENT SESSION VI - Shavano Peak "EVALUATION OF TERATOGENIC HAZARDSMSKS I" Co-Chairs: Dr. Patrick Wier & Dr. Rochelle Tyl

KEYNOTE LECTURER - Daniel W. Nebert, M.D., Director, Center for Environmental Genetics, University of Cincinnati Medical Center, Dept of Environmental Health, Cincinnati, OH

ENZYMES AND THEIR RECEPTORS IN DEVELOPMENTAL TOXICOLOGY USE OF "GENE KNOCK-OUT'' MOUSE LINES TO STUDY THE ROLE OF DRUG-METABOLIZING

50. Thayer* and F. Vom Saal*. *University of Missouri, Columbia, Missouri.

A PARADIGM INVERSION FOR LOW DOSE TOXICITY STUDIES - Sheehan, D.M., C.A. National Center for Toxicological Research, Jefferson, Arkansas and

51. INTERACTIONS OF DEGREE AND DURATION OF RADIOFREQUENCY RADIATION- INDUCED HYPERTHERMIA AND 2-METHOXYETHANOL TERATOGENICITY IN RATS - Nelson, B.K., D.L. Conover, E.F. Krieg, Jr., D.L. Snyder, and R.M. Edwards. NIOSH, Cincinnati, Ohio.

52. IN VIVO DEVELOPMENTAL EFFECTS OF DIBROMOACETIC ACID (DBA) AND DICHLOROACETIC ACID (DCA) IN MICE - Narotsky, M.G., B.T. Hamby*, D.S. Best*, andE.S. Hunter. Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, NC.



2:15 - 2:30 53. EFFECTS OF ETHYLENE GLYCOL MONOETHYL ETHER (EGME) ON EPIDIDYMAL SPERM PARAMETERS AND MALE FERTILITY IN SPRAGUE-DAWLEY (SD) RATS - Horimoto*, M., M.S. Tassinari, Y. Isobe*, Y. Isogia* and M. Tachibana*. Pfizer Inc. New Product Development Center, Taketoyo, Japan, and Central Research Division, Groton, CT.

2:30 - 2145

2145 - 3:OO

3:OO - 3115

3:15 - 3130

3:30 - 3:45

3~45 - 4:OO

4:OO - 4 ~ 1 5

630 - 7:30

7:30 - 1O:OO

54. A STUDY OF DOSE-RATE EFFECTS OF INHALED ETHYLENE OXIDE IN PREGNANT C57B1 MICE - Brain, J., N. Earley, R. Hennessey, L. Holmes, C. Kimmel, G. Kimmel, N. Long, L. Ryan*, W. Skomik, A. Smith, E. Weller, P. Williams. Harvard School of Public Health, Boston, MA and US Environmental Protection Agency Washington, DC.

55. APPLICATION OF THE WHOLE EMBRYO CULTURE SYSTEM IN SCREENING INDUSTRIAL TERATOGENS - Zhao*, S.F., X.C. Zhang*, F. Zhang*, L.F. Zhang* and Y.S. Bao* (Introduced by D.M. Kochhar). Department of Occupational Health, Beijing Medical University, Beijing, China.


56. STUDY OF FUMONlSIN B, IN PREGNANT RATS - Collins, T.F.X., M.E. Shackelford*, R.L. Sprando*, T.N. Black, J.B. LaBorde, D.K. Hansen, and D.I. Ruggles*. Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD and National Center for Toxicological Research, Jefferson, Arkansas.

57. ASSESSMENT OF THE EMBRYOTOXIC POTENTIAL OF THE TOTAL HYDROLYSIS

Ingram*, J. Yates*, M. Stack*, A. Troy*, and S. Chirtel*. Divisions of Toxicological Research, Natural Products and Mathematics, FDA, Laurel MD and Washington, DC.

5 s . BONE LEAD STORES IN ADULTHOOD FOLLOWING EARLY DEVELOPMENTAL LEAD EXPOSURE IN THE RHESUS MONKEY - Laughlin, N.K., F.E. McNeill*, B.A. Fowler*, and B.R. Sonawane. Harlow Center for Biological Psychology, University of Wisconsin, Madison, WI; Department of Physics and Astronomy, McMaster University, Ontario, Canada; Toxicology Program, University of Maryland, Baltimore, MD; and U.S. Environmental Protection, Washington, DC.

PRODUCT OF FUMONlSIN B, USING CULTURED RAT EMBRYOS - Fly~~n , T.J., 1. ROSS*, G.

59. SELECTION OF A CLINICALLY RELEVANT DOSE OF CORTICOSTEROIDS USED TO ENHANCE FETAL LUNG MATURITY AND THEIR EFFECT ON FETAL GROWTH AND DEVELOPMENT - Sienko', A.E., Christensen*, H.D., Raybum, W.F., Gonzalez*, C.L., and Coleman*, F.H. Departments of Obstetrics and Gynecology, Pharmacology/Toxicology, and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

BANQUET RECEPTlON/CASH BAR - Sbavano Foyer

BANQUET - Red Cloud/Shavano


THURSDAY, JUNE 27, 1996

7:30 - 8:OO 8100 - 1100 9:30 - 11:OO

8:OO - 10:15

8100 - 8:15

8:15 - 8:30

8:30 - 8:45

8:45 - 9:OO

9100 - 9115

9 ~ 1 5 - 10:15

8:OO - 10:15

8:OO - 8 ~ 1 5

8:15 - 8:55

8:55 - 9:35

9:35 - 10:15

10~15 - 10:30


PUBLIC AFFAIRS SYMPOSIUM - "THERAPEUTIC TERATOLOGY" - Shavano Peak

INTRODUCTION - Jan M Friedman, M.D., Ph.D., Dept Medical Genetics, Univ British Columbia, Vancouver, BC, Canada

THERAPEUTIC USES OF THALIDOMIDE Robert L. Brent, M.D., Ph.D., Research Dept, Division of Developmental Biology, Alfred I. DuPont Institute, Wilmington, DE

THALIDOMIDE TERATOGENICITY Reinhard Neubert, M.D., Ph.D., Freie Universitat Berlin, Fachbereich Humanmedizin, Institut fur Toxikdogie und Embryopharmakologie, Berlin, Germany

APPROACHES TO THE CONTROL OF FERTILITY IN WOMEN WHO NEED TO BE TREATED WITH TERATOGENIC DRUGS Anthony R. Scialli, M.D., Dept Obstetrics & Gynecology, Georgetown University Medical Center, Washington, DC

EXPERIENCE WITH EFFORTS TO PREVENT USE OF ISOTRETINOIN DURING PREGNANCY Carla Van Bennekom, M.P.H., Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MA

ROUNDTABLE DISCUSSION - ETHICAL ISSUES RAISED BY THE AVAILABILITY AND RESTRICTION OF TERATOGENIC DRUGS

SYMPOSIUM - "HORMONAL EFFECTS ON DEVELOPMENT IN HUMANS AND WILDLIFE" - Red Cloud Peak

INTRODUCTION - Robert J. Kavlock, Ph.D., US EPA, Research Triangle Park, NC

CONCENTRATIONS OF POLYCHLORO-DIAROMATIC HYDROCARBONS IN AND EFFECTS ON WILDLIFE OF THE NORTH AMERICAN GREAT LAKES John P. Giesy, Ph.D., Dept of Fisheries & Wildlife and Institute of Environmental Toxicology, Michigan State University, East Lansing, MI

THE DEVELOPMENTAL TOXICITY OF ENVIRONMENTAL ESTROGENS IN EXPERIMENTAL ANIMALS Daniel M. Sheehan, Ph.D., National Center for Toxicological Research, Jefferson, Arkansas

THE TERATOGENICITY AND CARCINOGENICITY ASSOCIATED WITH IN UTERO EXPOSURE TO DIETHYLSTILBESTROL (DES) Robert Mittendorf, M.D., Dr.P.H., Dept Obstetrics & Gynecology, Chicago-Lying-In Hospital, Chicago, IL



Thursday, June 27, 1996 - Continued

10:30 - 12:OO CONCURRENT SESSION VII - Shavano Foyer "MECHANISMS OF ABNORMAL DEVELOPMENT 11" Chair: Dr. Ronald Hood

10:30 - 10:45 60. LIMB DEFECTS IN N J MICE ASSOCIATED WITH MATERNAL BLOOD LOSS - Fawcett*, L.B., S.J. Buck*, and R.L. Brent. Department of Pediatrics, Jefferson Medical College, Philadelphia, PA and Department of Clinical Science, A.I. DuPont Institute, Wilmington, DE.

10:45 - 11:OO

11:OO - 11:15

11~15 - 11~30

11:30 - 11:45

11:45 - 12:OO

10:30 - 12:OO

10:30 - 10:45

10:45 - 11:OO

61. INHIBITION OF NITRIC OXIDE SYNTHASE BY L'-NITRO-L-ARGININE METHYL ESTER

TERATOGENIC ROLE FOR REDUCED FETAL BLOOD FLOW - Fantel, A.G., N. Nekahi, T.H. Shepard, L.M. Cornel, R.J. Lemire, and A.S. Unis. Departments of Pediatrics, Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA.

62. INITIATION OF PHENYTOIN TERATOGENESIS; PHARMACOLOGICALLY INDUCED EMBRYONIC BRADYCARDIA AND ARRHYTHMIA RESULTING IN HYPOXIA/ISCHEMIA AND POSSIBLE FREE RADICAL DAMAGE AT REPERFUSION - Danielsson, B.R.G., Azarbayjani, F*., and Wisen, A-C*. Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Uppsala, Sweden.

(L-NAME) CAUSES HIND LIMB AND BRAIN ANOMALIES IN FETAL RATS. A POTENTIAL

63. A NEW MODEL FOR ANALYZING NEURAXIAL MORPHOGENESIS; MOUSE/CHICK TRANSPLANTATION CHIMERAS - J. Thayer, D.K. Damell' and G.C. Schoenwolf. Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT.

64. ULTRASTRUCTURAL ANALYSIS OF MURINE LUNGS DISPLAYING CHONDRODYSTROPHY-ASSOCIATED PULMONARY HYPOPLASIA - Pace*, J.M., J.S. Gardner*, and R.E. Seegmiller. Department of Zoology and Department of Botany and Range Science, Brigham Young University, Provo, UT.

65. CONFOCAL LASER SCANNING MICROSCOPY OF THE PATHOGENESIS OF METHANOL- INDUCED CRANIOFACIAL DEFECTS IN C57BL16J MICE - Rogers, J.M., R.M. Zucker and K.C. Brannen. National Health and Environmental Effects Research Laboratory, US . Environmental Protection Agency, Research Triangle Park, and Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC.

CONCURRENT SESSION VIII - Red Cloud Peak "EVALUATION OF TERATOGENIC HAZARDSRISKS 11" Co-Chair: Dr. Jeanne Manson

66. THE EFFECTOF LIPOSOME ENCAPSULATION ON TAXOL DEVELOPMENTAL TOXICITY IN THE RAT - Goeringer, G.C., J.M. DeSesso, A. Rahman*, and A.R. Scialli. Departments of Cell Biology, Hematology and Oncology, and Obstetrics and Gynecology, Georgetown University Medical Center, Washington, DC and the MITRE Corporation, McLean, VA.

67. THE ESTABLISHMENT OF THE DANFORTH MICE AS A NATURALLY OCCURRING MODEL FOR THE STUDY OF COMPENSATORY RENAL GROWTH - Mesrobian, H-G.O., and Milling, D.M., Children's Hospital and the Medical College of Wisconsin, Milwaukee, WI. Medical University of South Carolina, Charleston, SC.

TERATOLOGY SOCIETY PROGRAM 75 Thursday, June 27, 1996 - Continued

11:oo - 11:15 68. CONSIDERATIONS IN CONDUCTING DEVELOPMENTAL AND TWO-GENERATION REPRODUCTIVE TOXICITY STUDIES USING DERMAL EXPOSURE IN THE RAT - Astroff, A.B., A.D. Young*, K.J. Freshwater*, D.R. Smith*, D.E. Phipps*, and M.J. Brown*. Toxicology Department, Bayer Corporation, Stilwell, KS.

11:15 - 11:30 69. CONTINUOUS INTRAVENOUS INFUSION IN RAT PERI- AND POST-NATAL STUDIES - Barrow*, P.C., and Heritier*, B. (Introduced by E. Robert). Pharmakon Europe, Les Oncins, L’Arbresle, France.

11130 - 11:45 70. EFFECTS OF SINGLE-DAY BORIC ACID TREATMENT ON AXlAL SKELETAL DEVELOPMENT IN RATS - Narotsky, M.G., B.T. Hamby*, D.S. Best*, and R.J. Kavlock. Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, NC.

11~45 - 12:OO 71. TOXIC EFFECTS OF CARBON DISULFIDE ON MOUSE OOCYTES - Bao*, Y.S., Q. Zheng*, H. Jiang’ and S.F. Zhao* (Introduced by D.M. Kochhar). Department of Occupational Health, Beijing Medical University, Beijing, China and Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA.

l:oo - 5:oo COUNCIL I1 MEETING - Boardroom

l:oo - 5:45 FREE TIME

5:45 - 6:30 GONDOLA RIDE TO RECEPTION - River Run

6:30 - 7:30

7 ~ 3 0 - 1O:OO

CASH BAR - Timber Ridge

WILSON AWARD DINNER - Timber Ridge

The Teratology Society Annual Meeting is supported in part by March of Dimes Birth Defects Foundation Grant No. 4-FY95-115 1.

76 TERATOLOGY SOCIETY PROGRAM POSTERS - 1996

Tuesday, June 25,1996 - Even Numbers - 7:30 pm - 9:OO pm - Odd Numbers - 9:OO pm - 1030 pm

Pl THE SELECTIVE ESTROGEN RECEPTORMODULATOR, RALOXIFENE: REPRODUCTIVE ASSESMENTS IN MALE RATS. Hoyt, J.A., L.F. Fisher*, D.K. Swisher*, R.A. Byrd, P.C. Francis*, Lilly Research Laboratories, Eli Lilly & Co., Greenfield, IN.

P2 THE SELECTIVE ESTROGEN RECEPTOR MODULATOR, RALOXIFENE: REPRODUCTIVE ASSESSMENTS FOLLOWING PREMATING EXPOSURE IN FEMALE RATS. Hoyt, J.A., L.F. Fisher*, J.L. Buelke-Sam, W.P. Hoffman*, P.C. Francis*, Lilly Research Laboratories, Eli Lilly & Co., Greenfield, IN.

P3 THE SELECTIVE ESTROGEN RECEPTOR MODULATOR, RALOXIFENE: REPRODUCTIVE ASSESSMENTS FOLLOWING PREIMPLANTATION EXPOSURE IN MATED FEMALE RATS. Clarke, D.O., K.1. Griffeyj, J.L. Buelke-Sam, and P.C. Francis*, Toxicology and Drug Disposition, Lilly Research Laboratories, A Division of Eli Lily & Co., Greenfield, IN.

P4 THE SELECTIVE ESTROGEN RECEPTOR MODULATOR RALOXIFENE: SEGMENT I1 STUDIES IN RATS AND RABBITS. Byrd, R.A., and P.C. Francis*, Toxicology ResearchLaboratories, Lilly ResearchLaboratories, Eli Lilly & Co., Greenfield, IN.

P5 THE SELECTIVE ESTROGEN RECEPTOR MODULATOR, RALOXIFENE: A SEGMENT IVIII DELIVERY STUDY IN RATS. I - MATERNAL AND PREWEANING OFFSPRING ASSESSMENTS. Buelke-Sam, J., K.I. Griffey*, P.W. Schwier*, and P.C. Francis*, Lilly Research Laboratories, Eli Lilly & Co., Greenfield, IN.

P6 THE SELECTIVE ESTROGEN RECEPTOR MODULATOR, RALOXIFENE: A SEGMENT IYIII DELIVERY STUDY IN RATS, I1 - POSTWEANING OFFSPRING ASSESSMENTS. Buelke-Sam, J., I. Cohen*, D. Wierda*, K. Griffey*, P. Schwier*, L. Fisher, III*, and P. Francis, Lilly Research Laboratories, Eli Lilly & Co., Greenfield, IN.

P7 NEONATAL TOXICITY STUDIES IN RATS: TECHNIQUES FOR GAVAGE DOSE ADMINISTRATION AND THE EXTRACTION OF BLOOD FOR PLASMA ANALYSIS. Aveyard*, L., R. Clark* and S.P. Mackay* (introduced by S.L. Morseth) Coming Hazleton Europe, Harrogate, England.

P8 INTERACTION BETWEEN VALPROIC ACID AND PHENYTOIN LEADING TO EMBRYONIC BRADYCARDINARRHYTHMIA AND AN INCREASED RISK FOR ISCHEMIAREPERFUSION DAMAGE. Azarbayjanij, F., Wisen*, A-C, and Danielsson, B.R.G., Dept of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Uppsala, Sweden.

P9 DEVELOPMENTAL EXPRESSION OF GRP78 IN MOUSE EMBRYOS AND EMBRYONIC HEARTS. Barnes*, J.A., and Smoak, I. W., Dept of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.

P10 S.L., Biology Dept., DePaul University, Chicago, IL.

FETAL AND MATERNAL CONTRIBUTIONS TO DIFFERENCES IN VALPROIC ACID TERATOGENICITY. Beck,

P11 EFFECT OF RAT HEPATIC S, FRACTIONS ON CBZ-INDUCED EMBRYOTOXICITY IN VITRO. Blum*, S., S.L. Dial', K.K. Terry, T.F. Grafton* and D.K. Hansen, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas.

P12 MORPHOMETRIC ANALYSIS OF RAT EMBRYOS DURING EARLY DEVELOPMENT USING LASER SCANNING CONFOCAL MICROSCOPY (LSCM). Bolon, B., W.S. Branham, A.R. Warbrittonj, D.M. Sheehan, and J.F. Young, Pathology Associates International and Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas.


PI3 EVALUATION OF THE DEVELOPMENTAL TOXICITY OF TRICLOPYR TRIETHYLAMINE SALT (TTEA) AND TRICLOPYR BUTOXYETHYL ESTER (TBEE) IN RATS. Breslin, W.J., R. Billington* and K. Jones*, The Dow Chemical Company, Midland, Michigan.

P14 EFFECTS OF TCDD ON EGF, TGFcr, AND EGF RECEPTOR IN EMBRYONIC MOUSE URINARY TRACT EPITHELIA. Bryant*, P.L., G.C. Clark* and B.D. Abbott, North Carolina Central University, Durham, North Carolina; XDS Inc., Durham, North Carolina; NHEERL, US EPA, Research Triangle Park, North Carolina.

P15 COMPARISON OF THE BIOCHEMICAL PROFILES OF MATERNAL PLASMA AND AMNIOTIC FLUID OF RAT AND MONKEY. Buttar, H.S., J.H. Moffatt, and J. Fournier', Bureau of Drug Research, Drugs Directorate, and Animal Resources Division, Health Protection Branch, Ottawa, Canada.

P16 ANALYSIS OF THE CELL-CYCLE, PROTEIN AND DNA LEVELS IN SPLEEN, THYMUS AND LIVER OF RATS PRENATALLY EXPOSED TO ACICLOVIR. Buttar, H.S., Moffatt, J.H., Langlois, I. and Mehta, R., Bureau of Drug Research, Drugs Directorate, and Bureau of Chemical Safety, Food Directorate, Health Protection Branch, Ottawa, Canada.

P17 AVOIDING DUPLICATION OF REGULATORY REVIEW: USE OF HAZARD IDENTIFICATION BY OUTSIDE "AUTHORITATIVE BODIES" FOR LISTING OF DEVELOPMENTAL AND REPRODUCTIVE TOXICANTS UNDER PROPOSITION 65. Campbell, M.A., J.M. Donald*, M.S. Golub*, J.E. Morgan', and M.S. Macintosh*, Office of Environmental Health Hazard Assessment (OEHHA), California Environmental Protection Agency, Sacramento, California.

P l 8 CORRELATION OF INHERENT PLASMA MEMBRANE GANGLIOSIDE GMI WITH MEMBRANE FLUIDITY AND SENSITIVITY OF MOUSE NEURAL CREST CELLS TO ETHANOL-INDUCED TOXICITY. Chen*, S.-Y., A. Periasamy*, B. Yang*, and K.K. Sulik, Dept of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

PI9 SYNERGISTIC EMBRYOTOXICITY OF COMBINATION PYRIMETHAMINE AND FOLIC ACID IN MICE. Chung*, M.K., J.C. Kim*, S.S. Han*, and J.K. Roh* (Introducedby H.W. Park) KRICT, Toxicology Researchcenter, Daejeon305-606, Korea.

P20 VISUAL IMPAIRMENT FROM PRE- AND POSTNATAL COCAINE EXPOSURE: CRITICAL PERIODS OF EXPOSURE. Church, M.W., G.W., Overbeck* and P.A. Holmes*, Dept Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, Michigan.

P21 VISUAL IMPAIRMENT FROM PRE- AND POSTNATAL REINOIC ACID EXPOSURE: CRITICAL PERIODS OF EXPOSURE. Church, M.W., G.W. Overbeck. and P.A. Holmes., Dept Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, Michigan.

P22 INHIBITION OF COLLAGEN SYNTHESIS IN CULTURED MOUSE EMBRYOS: EFFECTS ON DEVELOPMENT AND MYOGENIN EXPRESSION. Clarke, D.O., L.P. Hungate*, E.A.G. ChernoffL, J.L. Wallace*, and R.C. Smith*, Toxicology and Drug Disposition, and Animal Science Discovery Research, Lilly Research Laboratories, A Division of Eli Lilly & Co., Greenfield, IN.

P23 DEVELOPMENTAL TOXICITY OF ORANGE B WHEN GIVEN TO RATS BY GAVAGE. Collins, T.F.X., T.N. Black, J.I. Rorie*, R.L. Sprando*, and D.I. Ruggles*, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland.

P24 PREVALENCE VARIATIONS OF CLEFT LIP AND CLEFT PALATE IN CALIFORNIA BY MATERNAL RACE AND MATERNAL COUNTRY OF BIRTH. Croen, L.A., G.M. Shaw*, California Birth Defects Monitoring Program, Emeryville, California.

P25 EFFECT OF REPEATED ADMINISTRATION OF KETOCONAZOLE ON GENITAL ORGANS AND SEMEN IN THE MALE BEAGLE DOG. Delongeasl, J.L., C. Justice*, V. Labbe*, F. Falda-Buscaiot', J.P. Sarsat*, J.F. Leonard*, V. Albaladejo* and P. Guittin, Drug Safety Dept., Rhone-Poulenc Rorer, BP14, 94403 Vitry sur Seine, Cedex, France.

P26 ADVERSE DEVELOPMENTAL OUTCOME AFTER REPEATED ADMINISTRATION OF a-HEDERIN. Duffy', J.Y., Baines', D., Overmann*, G.J., and G.P. Daston, Miami Valley Laboratories, Procter & Gamble Co., Cincinnati, Ohio.


P27 and The Baltimore-Washington Infant Study Group, Dept of Epidemiology, University of Maryland, Baltimore, Maryland.

RISK FACTORS FOR PULMONARY VALVE STENOSIS. Ferencz, C., C.A. Loffredo, A. Correa-Villaseflor, P.D. Wilson,

P2S GERM-LAYER SPECIFIC PROPERTIES ARE NOT YET IRREVOCABLY DETERMINED IN AVIAN EMBRYOS AT LATE GASTRULMEARLY NEURULA STAGES. Garcia-Martinez*,V., D.K. Darnell*, and G.C. Schoenwolf, Dept ofNeurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah.

P29 EFFECTS OF METHOTREXATE ON PROGESTERONE PRODUCTION BY CULTURED RAT GRANULOSA CELLS AND THE POTENTIAL AMELIORATIVE EFFECTS OF LEUCOVORIN. Goeringer, G.C., A.R. Scialli, J.M. DeSesso, and T. Crisp*, Depts of Cell Biology and Obstetrics and Gynecology, Georgetown University Medical Center, Washington, D.C., The MITRE Corporation, McLean, Virginia, and US . Environmental Protection Agency, Washington, D.C.

P30 ANTISENSE COX-2 INDUCES PROSTAGLANDIN E2 - REVERSIBLE ANOMALIES IN CULTURED MOUSE EMBRYOS. Goldman, AS., M.P. Goto* and G.E. Hoganson*, Dept of Pediatrics, University of Illinois, Chicago, Illinois.

P31 LACK OF AMELIORATION OF VALPROIC ACID-INDUCED EMBRYO-TOXICITY BY TTI IN VZTRO. Grafton*, T.F., S.L. Dial*, K.K. Terry and D.K. Hansen, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas.

P32 TERATOGENIC EVALUATION OF ALTERNATIVE VEHICLES: PEG 400, CREMOPHOR, CARBOXY- METHYLCELLULOSE: COMPARISONS WITH METHYL-CELLULOSE. Gupta, U., Beaulieu*, J., Chapin Hopper*, J., Hagler*, A.R. and P. Hills-Perry*, Pfizer Central Research, Groton, Connecticut.

P33 and R.E. Seegmiller, Dept. of Zoology, Brigham Young University, Provo, Utah.

DEVELOPMENTAL TOXICITY OF CARBON BLACK OIL IN SWISS-WEBSTER MICE. Hansen*, J.M., G.M. Booth*

P34 PLACENTAL TRANSFEWSECRETION IN MILK OF rhDNASE IN CYNOMOLGUS MONKEYS. Hardy, L., G. McCormick*, D. Sinicropi*, S. Baughman*, I. Osterburg, and R. Korte, Genentech, Inc., South San Francisco, California and Coming Hazleton Europe, Munster, Germany.

P35 Shaw*, G.M., California Birth Defects Monitoring Program, Emeryville, California.

AN ANTHROPOLOGIC APPROACH TO GENERATING CLUES ABOUT TERATOGENS. Harris*, J.A., Strick, B.,

P36 ACTIVATION OF THE MATERNAL IMMUNE SYSTEM DOES NOT PREVENT ALL-TRANS RETINOIC ACID- INDUCED VERTEBRAL ANTERIORIZATION. Hartig, P.C. and Hunter, E.S., Reproductive Toxicology Division, NHEERL, U.S. EPA, Research Triangle Park, North Carolina.

P37 DEVELOPMENTAL TOXICITY OF CLINAFLOXACIN HYDROCHLORIDE, A QUINOLONE ANTIINFECTIVE AGENT. Henck, J.W., L.A. Dostal, and J.A. Anderson, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, Michigan.

P38 HISTORICAL CONTROL DATA IN DEVELOPMENTAL TOXICITY STUDIES USING SPRAGUE-DAWLEY RATS AND NEW ZEALAND WHITE RABBITS. Hew, K.W., and D.E. Rodwell, Springborn Laboratories, Inc., Spencerville, Ohio.

P39 MATERNAL DIABETES AND MATERNAL COPPER DEFICIENCY RESULT IN INCREASED OXIDATIVE DAMAGE (DNA-PROTEIN CROSSLINKS) IN GESTATION DAY 11.0 RAT EMBRYOS. Jankowski, M.A., J.Y. Uriu-Hare, R.B. Rucker', and C.L. Keen, Dept of Nutrition, University of California, Davis, Davis, California.

P40 and S.A. Tredwell', Dept. of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada.

DIETARY EFFECT ON FREQUENCY OF EXENCEPHALY IN SELWBc MICE. Juriloff, D.M., M.J. Harris, J.L. Hall*,


P41 EARLY EFFECTS OF HEAT STRESS ON SOMITOGENESIS IN THE RAT. Kimmel, G.L., T.W. Claggett, C.A. Kirnmel, J.L. Rojko*, and N. Tudor*, National Center for Environmental Assessment/ORD, US EPA, Washington, D.C.; Pathology Associates International, Frederick, Maryland; and Center for Devices and Radiological Health, FDA, Rockville, Maryland.

P42 DEVELOPMENTAL TOXICITY OF FUMONISIN (FB.) IN NEW ZEALAND WHITE (NZW) RABBITS. LaBorde, J.B., K.K. Terry, T.F.X. Collins, M.E. Schackelford and D.K. Hansen, National Center for Toxicological Research, and Center for Food Safety and Applied Nutrition, Food and Drug Administration, Jefferson, Arkansas and Laurel, Maryland.

P43 and K.K. Sulik, Depts of Cell Biology and Anatomy and Pathology, University of North Carolina, Chapel Hill, North Carolina.

P44 and G.A. Held*, NHEERL, US EPA, Research Triangle Park, North Carolina.

EXPRESSION OF THE APOLIPOPROTEIN B GENE IN MOUSE EMBRYOS. Lanoue*, L., M.E. Hinsdale, N. Maeda,

REGULATION OF GLUCOCORTICOID RECEPTOR (GR) IN THE RAT EMBRYO. Lau*, C., C. Wood*, B.D. Abbott

P45 LIPOPOLYSACCHARIDE (LPS) EMBRYOLETHALITY IN THE CD-1 MOUSE: ROLE OF TUMOR NECROSIS FACTOR-a (TNF-a). Leazer, T.M.* and J.M. Rogers, Curriculum in Toxicology, Univ of North Carolina, Chapel Hill, NC; DBB, NHEERL, US EPA, Research Triangle Park, NC.

P46 INDUCTION OF CONGENITAL ANOMALIES AND DOMINANT LETHALITY IN OFFSPRING OF MALE MICE IRRADIATED TO *''Cf FISSION NEUTRONS AT PRE-MEIOTIC AND POST-MEIOTIC STAGES OF GERM CELLS. Lee, J.Y. (Shoji, S.), H. Watanabe, A. Ito, K. Komatsu, Y. Satow, and Y.C. Lin, Dept of Environmental Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan and Lab. Reprod. & Molec. Endoc., College of Veterinary Medicine, The Ohio State University, Columbus, Ohio.

P47 Llirbat*, B., Wolfc, C., Chevy*, F., Citadelle*, D., Roux*, C., Unit6 de Spectrornetrie de Masse (URA CNRS 1283, Pr Bereziat); Laboratoire D'embryologie, CHU St-Antoine, Pans, France.

P48 A COMPARATIVE EPIDEMIOLOGIC EVALUATION OF RISK FACTORS FOR HYPOPLASTIC LEFT HEART SYNDROME, AORTIC STENOSIS, AND COARCTATION OF THE AORTA. Loffredo, C.A., C. Ferencz, J.D. Rubin, A. Correa- Villasenor, P.D. Wilson, and The Baltimore-Washington Infant Study Group, Dept of Epidemiology, University of Maryland, Baltimore, Maryland.

P49 DEVELOPMENTAL TOXICITY OF METHYL MERCURY CHLORIDE AND METHOTREXATE IN INTACT DROSOPHILA. Lynch*, D.W. (Introduced by B.K. Nelson), NIOSH, DBBS, Experimental Toxicology Branch, Cincinnati, Ohio.

P50 GLUTATHIONE STATUS IN DIABETES-INDUCED EMBRYOPATHIES. Menegola, E., Broccia, M.L., Prati, M., Ricolfi, R., and Giavini, E., Dept. of Biology, University of Milan, Milan, Italy.

P51 DEVELOPMENTAL TOXICITY OF 2-CHLORO-2'-DEOXYADENOSINE (2-CdA, CLADRIBINE). Mitala, J.J., A.M. Hobennan, E.W. Thompson*, and J.W. Oldham, The R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey; Argus Research Laboratories, Inc., Horsham, Pennsylvania.

PS2 GERM CELL APOPTOSIS DURING MOUSE TESTIS DEVELOPMENT. Mori*, C., N. Nakarnura*, S. Nakagawa*, Y.J. Gu*, and K. Shiota, Dept of Anatomy and Developmental Biology, Faculty of Medicine, Kyoto University, Kyoto; Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.

AN IN VITRO STUDY OF NORMAL AND ALTERED CHOLESTEROL BIOSYNTHESIS IN THE RAT EMBRYO

P53 ALTERED PAX-1 AND HOXA-3 EXPRESSION IS ASSOCIATED WITH ALL-TRANS RETINOIC ACID INDUCED THYMIC ABNORMALITIES IN THE MOUSE. Mulderl, G.B., N. Manley*, S. Thompson* and L. Maggio-Price* (Introduced by M.L. Cunningham), Depts of Comparative Medicine and Environmental Health, University of Washington, Seattle, Washington and Dept. of Human Genetics, University of Utah, Salt Lake City, Utah.


P54 Laboratory, DuPont, Newark, Delaware.

DEVELOPMENTAL TOXICITY STUDY OF GLYCOLIC ACID IN RATS. Munley*, S.M., and M.E. Hurtt, Haskell

P55 Nakagawa*, S., C. Mori*, N. Nakamura*, and K. Shiota, Dept of Anatomy and DevelopmentalBiology, Faculty of Medicine, Kyoto University, Kyoto; Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan

P56 WHOLE-MOUNT IN SITU HYBRIDIZATION ANALYSIS OF HOXD-11 EXPRESSION IN BrdU-INDUCED LIMB TERATOGENESIS IN MICE. Nakamura*, N., C. Mori*, and K. Shiota, Dept of Anatomy and Developmental Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan.

SPERMATOGENIC CELL APOPTOSIS INDUCED BY MITOMYCIN C IN THE MOUSE TESTIS.

P57 EFFECTS OF GLUTATHIONE OR N-ACETYLCYSTEINE ON TERATOGENICITY OF 5-FLUOROURACIL IN MICE. Naya, M., K. Shuto* and M. Yasuda, Toxicological Research Laoratories, Kyowa Hakko Kogyo Co., Ltd., Ube, Yamaguchi, Japan; and Dept of Anatomy, Hiroshima University School of Medicine, Hiroshima, Japan.

P58 SYNERGISM: EXPOSURE TO MULTIPLE AGENTS WITH RESPECT TO THEIR INDIVIDUAL "THRESHOLDS" FOR TOXICITY. Newman, L.M., Haghdoost*, N.R., and E.M. Johnson, Dept of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

P59 and J.E. Andrews, Reproductive Toxicology Division, NHEERL, US EPA, Research Triangle Park, North Carolina.

P60 CHEMICAL TERATOGENS FROM PLANTS. Olsen*, P.L., C.S. Forsyth*, and A.A. Frank, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon; Oak Ridge National Laboratory, Oak Ridge, Tennessee; Dept of Pathology, College of Veterinary Medicine, Colorado State University, Fort Collins, Colorado.

THE EFFECTS OF FORMATE ON CD-I MOUSE LIMB BUD DEVELOPMENT. Nichols*, H.P., M.T. Ebron-McCoy*,

P61 INDUCTION OF CELL CYCLE GENES IN PRIMARY RODENT EMBRYONIC CELLS AFTER IN VITRO EXPOSURE TO METHYLMERCURY. Ou*, Y-C, Thompson, S.A., Kirchner, S.C., Kavanagh, T.J., Faustman, E.M., Dept of Environmental Health, University of Washington, Seattle, Washington.

P62 CHLORAMBUCIL-INDUCED POSTCLOSURE EXENCEPHALY AND AXIAL SKELETAL MALFORMATIONS IN THE RAT. Padmanabhan, R. and Samad, P.A., Dept of Anatomy, UAE University, Al Ain, United Arab Emirates.

P63 THE TRANSPLACENTAL PHARMACOKINETICS AND DISTRIBUTION OF AZIDOTHYMIDINE (AZT) AND ITS MAJOR METABOLITE, THE GLUCURONIDE (AZTG), IN NEAR-TERM FWESUS MACAQUES. Patterson*, T.A., Z. Binienda*, W. Slikker, Jr. and J.A. Sandberg*, Division of Neurotoxicology, National Center for Toxicological Research,FDA, Jefferson, Arkansas.

P64 MATERNAL DIETARY ZINC (Zn) DEPRIVATION DOES NOT EXACERBATE THE EFFECT OF LOW DOSE IRRADIATION ON EMBRYO AND FETAL DEVELOPMENT IN MICE. Peters, J.M., Hanna', L., Wiley*, L.M., Zidenberg-Cherr, S., and C.L. Keen, University of California, Davis, California.

P65 A SINGLE ORAL DOSE OF RETINYLPALMITATE MAY CAUSE A TRANSIENT DELAY IN NEURAL TUBE CLOSURE IN RAT EMBRYOS. Piersma, A.H., Verhoef, A., Olling, M., Unit Teratology, Endocrinology and Perinatal Screeening; and Unit Biotransformation and Pharmaco- and Toxicokinetics, National Institute for Public Health and Environmental Protection, Bilthoven, The Netherlands.

P66 DEVELOPMENTAL TOXICITY EVALUATION OF a-CYCLODEXTRIN IN MICE AND RATS. Price, C.J., Navarro, H.A., Marr, M.C., Myers, C.B., Hunter, E.S., and Schwetz, B.A., ResearchTriangle Institute andNational Toxicology PrograrnDIIEHS, Research Triangle Park, North Carolina.

P67 FETAL DISTRIBUTION OF AZIDOTHYMIDINE (AZT), ITS GLUCURONIDE (AZTG), AND PHOSPHORYLATED METABOLITES IN NEAR-TERM RHESUS MACAQUES AFTER MATERNAL INFUSION. Sandberg*, J.A., Z. Binienda*, W. Slikker, Jr. and T.A. Patterson*, Division of Neurotoxicology, National Center for Toxicological ResearcWFDA, Jefferson, Arkansas,


P68 COMPARISON OF RISK FACTORS FORNEURAL TUBE DEFECT-AFFECTED PREGNANCIES BETWEENHISPANIC AND WHITE WOMEN. Shaw, G.M., E.M. Velie*, California Birth Defects Monitoring Program, Emeryville, California.

P69 NEURAL TUBE CLOSURE IN HUMAN EMBRYOS INITIATES AT MULTIPLE SITES. Shiota, K., Nakatsu*, T., Yamada*, S. and Uwabe*, C., Dept of Anatomy and Developmental Biology, and Congenital Anomaly Research Center, Kyoto University Faculty of Medicine, Kyoto, Japan.

P70 MORTALITY IN MICE. Singh, J., and L. Moore-Cheaturn*, Stillman College, Tuscaloosa, Alabama.

INTERACTIONS OF GESTATIONAL PROTEIN DEFICIENCY AND CARBON MONOXIDE EXPOSURE ON BIRTH

P71 ALTERATION OF GLUCOSE METABOLISM BY OHAs IN EARLY-SOMITE MOUSE EMBRYOS IN VITRO. Smoak, I. W., Dept of Anatomy, Physiological Sciences, and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

P72 INHIBITORY MECHANISM AGAINST CLEFT PALATE IN EXENCEPHALIC MOUSE FETUSES EXPOSED TO 2,3,7,8- TETRACHLORODIBENZO-p-DIOXIN (TCDD), WITH SPECIAL REFERENCE TO CELL PROLIFERATION. Takagi*, T., K.A. Matsui', K. Yamshita*, M. Yasuda, K. Yajin*, and Y. Harada*, Dept of Otolaryngology and Dept of Anatomy, Hiroshima University School of Medicine, Hiroshima, Japan.

P73 CORRELATIONS OF DEXAMETHASONE (DEX) EXPOSURE AND DEVELOPMENTAL TOXICITY IN RATS. Terry, K.K., J.B. LaBorde, D.K. Hansen, and R.R. Holson, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas.

P74 A COMBINED SEGMENT VII STUDY OF LY303870 (A NK-1 RECEPTOR ANTAGONIST) ADMINISTERED ORALLY TO RATS. Tizzano*, J., G. Murphy*, J. Hoyt, L. Fisher*, C. McMillian*, R. Van Lier*, and R. Byrd, Toxicology Research Labs, Lilly Research Labs, Eli Lilly & Co., Greenfield, Indiana.

P75 DETECTION, CLASSIFICATION, AND DESCRIPTION OF MINOR LIMB ANOMALIES BY DERMATOGLYPHICS ON VOLAR SKIN OF MICE. Tsugane*, M.H., and M. Yasuda, Dept of Anatomy, Hiroshima University School of Medicine, Hiroshima, Japan.

P76 INVESTIGATION INTO THE TERATOGENIC POTENTIAL OF ANTISENSE OLIGODEOXYNUCLEOTIDES TARGETED TO ah-FGF2 mRNA IN THE CARDIOVASCULAR SYSTEM OF THE STAGE 12 CHICK EMBRYO. Watkins*, B.P., and G.L. Kolesari, Dept of Cellular Biology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.

P77 University of Sydney, Sydney, Australia; Dept of Toxicology, University of Uppsala, Uppsala, Sweden.

PHENYTOIN-INDUCED BRADYCARDIA IN RAT-EMBRYOS. Webster, W.S., and B.R. Danielsson, Dept of Anatomy,

P78 EVALUATION OF A NEW ANXIOLYTIC AND ANTIDEPRESSANT, CP-93,393: PRE- AND POSTNATAL STUDY M RATS. Weisenburger, W.P., Kozak*, C.L., Medeiros*, L.A., and D.S. Chapin*, Pfizer Central Research, Groton, Connecticut.

P79 STANDARDIZED ELECTRONIC DATA FILE FORMAT FOR EXCHANGE OF ANIMAL TOXICOLOGY STUDIES. Wise, L.D., P.E., McConnell*, and J.M. Carley*, Merck ResearchLaboratories, West Point, Pennsylvania; E.I. DuPont, Wilmington, Delaware; US EPA, Washington, D.C.

P80 and K. Yamashita*, Dept of Anatomy, Hiroshima University School of Medicine, Hiroshima, Japan.

NORMAL AND ABNORMAL DEVELOPMENT OF PALATAL RUGAE IN MICE. Yasuda, M., K.A. Matsui*, T. Takagil,

Documents

The Teratology Society Thirty-Sixth Annual Meeting June 22-27, 1996