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TheTheTheTheTheTheTheThe UK UK UK UK UK UK UK UK RusselRusselRusselRusselRusselRusselRusselRussel Group Group Group Group Group Group Group Group
UniversitiesUniversitiesUniversitiesUniversitiesUniversitiesUniversitiesUniversitiesUniversitiesUniversity of BirminghamUniversity of BristolUniversity of CambridgeCardiff UniversityUniversity of EdinburghUniversity of GlasgowImperial College LondonKing's College LondonUniversity of LeedsUniversity of LiverpoolLondon School of EconomicsUniversity of ManchesterNewcastle UniversityUniversity of NottinghamUniversity of OxfordQueen's University BelfastUniversity of SheffieldUniversity of SouthamptonUniversity College LondonUniversity of Warwick
Facts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about Queen’’’’’’’’ssssssss
Founded in 1845Founded in 1845Founded in 1845Founded in 1845
17,20017,20017,20017,200 undergraduate students
5,5005,5005,5005,500 postgraduate students
1,200 1,200 1,200 1,200 international students
3,6003,6003,6003,600 staff (1000+ researchers)
Facts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about QueenFacts about Queen’’’’’’’’ssssssss
� Noted for excellent in student experienceNoted for excellent in student experienceNoted for excellent in student experienceNoted for excellent in student experience
� Multiple international links,Multiple international links,Multiple international links,Multiple international links,
� e.g. Europe, India, China, Malaysia and the US.e.g. Europe, India, China, Malaysia and the US.e.g. Europe, India, China, Malaysia and the US.e.g. Europe, India, China, Malaysia and the US.
� Growing links with ThailandGrowing links with ThailandGrowing links with ThailandGrowing links with Thailand
� Entrepreneurial University of the Year 2009 Entrepreneurial University of the Year 2009 Entrepreneurial University of the Year 2009 Entrepreneurial University of the Year 2009
� A patron of the arts, Belfast Festival at QueenA patron of the arts, Belfast Festival at QueenA patron of the arts, Belfast Festival at QueenA patron of the arts, Belfast Festival at Queen’’’’ssss
� The University has more than 250 buildings, manyThe University has more than 250 buildings, manyThe University has more than 250 buildings, manyThe University has more than 250 buildings, many
listed as being of special architectural meritlisted as being of special architectural meritlisted as being of special architectural meritlisted as being of special architectural merit
Opened in 2009Opened in 2009Opened in 2009Opened in 2009
�Cost: $80 million (2.4Billion Bhat)
�2,000 reader places
�1.2 million books
Seamus Heaney David Trimble
University Structure
Three Faculties
•Life Sciences & Medicine
•Physical Sciences
•Humanities
Evolu
tionar
y
Biolo
gy
Animal
Behaviour &
Welfa
re
Ecolo
gy
Environm
enta
l
Econom
ics
Microbio
logy
Bioch
emist
ry
Paras
itolo
gy
Food Saf
ety &
Nutritio
n
ASSETASSETASSETASSET: Centre for Assured Safe and Traceable Food
GIBSON GIBSON GIBSON GIBSON INSTITUTEINSTITUTEINSTITUTEINSTITUTE: Centre for
Environmental Economics
QUESTORQUESTORQUESTORQUESTOR:Cooperative Microbiology
Research Centre
Animal Health
Animal Welfare
Food Safety
Nutrition
Project Title: Determining the extent of human exposure to toxic agents present in drinking water by identification of specific biomarkers
Principal InvestigatorChris Elliott, Professor of Food Safety
MicrocystinsAnatoxinsCylindrospermopsinHarmful amino acids
CancerLiver diseaseNeurological diseases
Project Title: Rapid multiplex analysis of plant alkaloids in feed, food and herbal supplements
Principal InvestigatorKatrina Campbell,
Lecturer in Biomolecular Targets
Katrina [email protected]
Plant Alkaloids
Tropane
Pyrrolizidine
Ergot
Opoid
Health effects
Liver cirrhosis
Cancer
Hallucinations
Convulsions
Neurological disorders
Quality Assurance
Quality Control
Science
Food Security
Traceability
Sensors
ConsumerConfidence
Biosensor
Technology Novel
BindersField based sensor testing
or HACCP Testing in
Food supply chain
Current methods of
detection LC-MS/MS
Lab based equipment
Project Title: Effect of low dose levels of marine biotoxinson cell line systems related to human disease
Principal InvestigatorKatrina Campbell
Lecturer in Biomolecular Targets
Katrina [email protected]
Identification of expressed protein biomarkers
by variety of different methods
Acute toxicity
No scientific evidence on low dose levels over prolonged periods????
Cell line expression systems
fed low toxin doses
In vivo studies to identify biomarkers
in animals fed low toxin doses
Correlate biomarkers to diseases
in different populations
Marine Biotoxins
Paralytic shellfish toxins
Diarrheic shellfish toxins
Amnesic shellfish toxins
Neurotoxic shellfish toxins
Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants Rapid immunodiagnostics for chemical contaminants in food and the environmentin food and the environmentin food and the environmentin food and the environmentin food and the environmentin food and the environmentin food and the environmentin food and the environmentDr Chen SITU (Dr Chen SITU (Dr Chen SITU (Dr Chen SITU (Dr Chen SITU (Dr Chen SITU (Dr Chen SITU (Dr Chen SITU ([email protected]@[email protected]@[email protected]@[email protected]@qub.ac.uk))))))))
Agrochemicals Agri-food production Food safety issues Food safety monitoring
Dipstick ELISA SPR biosensor
Project Title: Endocrine disrupting compounds in food and the environmentPrincipal Investigator:Dr Lisa Connolly
Lecturer in Toxin Food [email protected]
Interference of the endocrine system at the nuclear and/or hormone production level.
• Man-made (pesticides, pharmaceuticals, industrial chemicals)• Natural chemicals (hormones, mycotoxins, phytoestrogens)
Endocrine disruptors
Food chain,Drinking water
Personal care products
Environment,Waste waters
Cancer Infertility
MalformationsBirth defects
Mammalian cell cultureToxicological assaysReporter gene assay
Steroidogenesis assayFluorescent microscopyHybridoma technology
Mass spectrometry
IdentificationMechanism
EffectsRisk assessmentExposure control
Exposure
Project Title: Modern energy-efficient drying technologies and their effect of quality of dried fruits and vegetables
Principal InvestigatorTassos Koidis , Lecturer in Food Science
Novel drying methods
Energy
Analysis
ModellingPredict quality and optimum drying
conditions
Project Title: Phosphorus removal and recovery from waste.
Principal InvestigatorJohn McGrath, Senior Lecturer
Environmental Microbiology
Freshwater eutrophicationcaused by phosphorus discharge: single biggest threat to water quality globally
Paradoxically phosphorus running out, with current reserves only sufficient to last 45 – 100 years.
Project Title: Towards a genomic-understanding of the marine phosphorus cycle.
Principal InvestigatorJohn Quinn, Reader
Environmental Microbiology
Microbes must access less
readily forms of phosphorus
‘OmicsIdentification of: •Novel genes and enzymes of phosphonate metabolism
•Drugs and drug precursors.
Project Title: Making parasite/host co-evolution work for us: Controlling liver flukes with incompatible hosts.
Principal InvestigatorAlan Trudgett, Senior Lecturer in
Biological [email protected]
Snails #23 and #34 - cercariae shed per day
Day of Shedding
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28
Num
ber
of C
erca
riae
Cou
nted
0
10
20
30
40
50
60
70
#23#34
Collect local populations of flukes and their intermediate host, a (lymnaeid) mud snail.
Use advanced molecular techniques and virulence assays to determine genotypes, population structure and snail/fluke compatibility.
54
64
64
67
95
7363
89
67
H3H35H31H6
H26H25H27H34H4H2H13H5
H9H18H10H38H23H36H20H1H17
H33H30H32H16H29H21H22H24
H7H8H14H11H12H28H19H37
I
II
III
Can incompatible snails be substituted for fluke-compatible ones in a field situation?
Project Title: Cellular response to hypoxia and ischemia/reperfusion damage.
Principal InvestigatorDr Alexander Galkin, :Lecturer in Biochemistry
Infarction / StrokeNeurodegenerationSurgery
Cancer cellsHypoxia (O2↓)ReoxygenationOxidative and nitrosative stress
Functional and structural analysis of oxidative phosphorylation and ROS production
Warburg effect
Project Title: Determining the structure and function of membrane transporter proteins involved in antibiotic resistance
Principal InvestigatorChris Law, Lecturer in Biochemistry
Project Title: The biochemical basis of the genetic disease galactosemia
Principal InvestigatorDavid J Timson, Senior Lecturer in Biochemistry
Galactose metabolising enzymes
Normal function•Recombinant expression/purification•Enzymology•Inhibition•Stability•Co-factor interactions•Enzymes from other species
Disease-associated variants•Site-directed mutagenesis•Recreate disease-associated variants•Assess biochemistry•Collaborations with labs in USA
0 200 400 600 8000
10
20
30
[UDP-Gal]/µµµµM
Sp
ec
ific
Ra
te/
µµ µµm
ol U
DP
-Glc
.min
-1.m
g-1
Relate biochemistry to disease•Particular emphasis on alleles from non-Western populations•Refer back to structures•Identify allosteric modifiers•Discover “small molecule chaperones”
R333
L74
F171
F194D28
D28F194
F171
L74
R333
C + + + + + + + M For Rev
Gal-1P
Glc-1P
UDP-Glc
UDP-Gal
Project 1 The electric sense in fish
Understanding sensory systems in animal navigationRichard Holland, Lecturer in Animal [email protected]
Project 2 Magnetoreception
Training
TestingMaze learning canreveal differences inmemory mechanisms
Sensory manipulationand biotelemetryinvestigate the roleof the magnetic sensein a natural setting
Evolu
tionar
y
Biolo
gy
Animal
Behaviour &
Welfa
re
Ecolo
gy
Environm
enta
l
Econom
ics
Microbio
logy
Bioch
emist
ry
Paras
itolo
gy
Food Saf
ety &
Nutritio
n
