2004 Carbohydrates

CarbohydratesU 0500 Thioglycosynthases: Double Mutant Glycosidases that Serve as Scaffolds for

Thioglycoside Synthesis. — A double mutant glycosidase that lacks both the catalytic nucleophile and the catalytic acid/base residues efficiently catalyzes thioglycoside for-mation from a glycosyl fluoride donor (I) and thiosugar acceptors (II). — (JAHN, M.; CHEN, H.; MUELLEGGER, J.; MARLES, J.; WARREN, R. A. J.; WITHERS, S. G.; Chem. Commun. (Cambridge) 2004, 3, 274-275; Dep. Chem., Univ. British Columbia, Vancouver, B. C. V6T 1Z1, Can.; Eng.) — R. Staver

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