1
2002 nucleic acids nucleic acids U 0700 39 - 215 Thiophosphorylation of Biologically Relevant Alcohols by the Oxathi- aphospholane Approach. Reaction of the 1,3,2-oxathiaphospholanes (I), (III) and (V) with 3-hydroxypropionitrile in the presence of DBU followed by treatment with ammonia opens a valuable access to phosphorothioates (II), (IV) and (VI). — (OLESIAK, MAGDALENA; KRAJEWSKA, DANUTA; WASILEWSKA, EWA; KORCZYNSKI, DARIUSZ; BARANIAK, JANINA; OKRUSZEK, ANDRZEJ; STEC, WOJCIECH J.; Synlett (2002) 6, 967-971; Dep. Bioorg. Chem., Cent. Mol. Macromol. Stud., PL-90-363 Lodz, Pol.; EN) 1

Thiophosphorylation of Biologically Relevant Alcohols by the Oxathiaphospholane Approach

Embed Size (px)

Citation preview

Page 1: Thiophosphorylation of Biologically Relevant Alcohols by the Oxathiaphospholane Approach

2002 nucleic acids

nucleic acidsU 0700

39 - 215Thiophosphorylation of Biologically Relevant Alcohols by the Oxathi-aphospholane Approach. — Reaction of the 1,3,2-oxathiaphospholanes(I), (III) and (V) with 3-hydroxypropionitrile in the presence of DBU followedby treatment with ammonia opens a valuable access to phosphorothioates (II),(IV) and (VI). — (OLESIAK, MAGDALENA; KRAJEWSKA, DANUTA;WASILEWSKA, EWA; KORCZYNSKI, DARIUSZ; BARANIAK, JANINA;OKRUSZEK, ANDRZEJ; STEC, WOJCIECH J.; Synlett (2002) 6, 967-971;Dep. Bioorg. Chem., Cent. Mol. Macromol. Stud., PL-90-363 Lodz, Pol.; EN)

1