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Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 1 of 69
Kavayitri Bahinabai Chaudhari
NORTH MAHARASHTRA UNIVERSITY,
JALGAON (M.S.)
Third Year Engineering
(Biotechnology Engineering)
Faculty of Science and Technology
SYLLABUS
Semester – V & VI
W.E.F. 2020 – 21
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 2 of 69
Syllabus Structure for Third Year Engineering (Semester – V) (Biotechnology Engineering) (w.e.f. 2020 – 21)
Name of the Course Group
Teaching Scheme Evaluation Scheme
Credits
Theory Practical
Total Theory
Hrs /
week
Tutorial
Hrs /
week
Practical
Hrs /
week
Total ISE ESE ICA ESE
Molecular Biology D 3 - - 3 40 60 - - 100 3
Reaction Engineering D 3 - - 3 40 60 - - 100 3
Enzyme Engineering D 3 - - 3 40 60 - - 100 3
Professional Elective Course –I E 3 - - 3 40 60 - - 100 3
Open Elective Course – I F 3 - - 3 40 60 - - 100 3
LAB Molecular Biology D - - 2 2 - 25 25(OR) 50 1
LAB Reaction Engineering D - - 2 2 - 25 25(OR) 50 1
LAB- Pharmaceutical Biotechnology D - - 2 2 - - 25 25(OR) 50 1
Minor Project (Stage-I) G - - 6 6 - - 50 - 50 3
Constitution of India - - - - - - - - - 0
15 0 12 27 200 300 125 75 700 21
ISE: Internal Sessional Examination ESE: End Semester Examination ICA: Internal Continuous Assessment
Professional Elective Course – I Open Elective Course – I
1 Food Biotechnology 1 Biofuel & Alcohol Technology
2 System Biology 2 Bioorganic Chemistry
3 Biothermodynamics 3 Biomedical Instrumentation
4 Cell Biology 4 Energy Engineering
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 3 of 69
ISE: Internal Sessional Examination ESE: End Semester Examination ICA: Internal Continuous Assessment
Professional Elective Course – II Open Elective Course – II
1 Plant Biotechnology 1 Environmental Biotechnology
2 Protein Engineering 2 NanoBiotechnology
3 Metabolic Engineering 3 Enterprise Resource Planning & SAP
4 Stem Cell Technology 4 Bioprocess Instrumentation and Analysis
*Internship - II is a mandatory and non-credit course. It shall be during summer vacation after semester – VI. The satisfactory completion of
Internship should be submitted to university at the end of semester VIII.
Syllabus Structure for Third Year Engineering (Semester – VI) (Biotechnology Engineering ) (w.e.f. 2020 – 21)
Name of the Course Group
Teaching Scheme Evaluation Scheme
Credits
Theory Practical
Total Theory
Hrs /
week
Tutorial
Hrs /
week
Practical
Hrs /
week
Total ISE ESE ICA ESE
Genetic Engineering D 3 - - 3 40 60 - - 100 3
Mass Transfer D 3 - - 3 40 60 - - 100 3
Bioprocess Engineering D 3 - - 3 40 60 - - 100 3
Professional Elective Course – II E 3 - - 3 40 60 - - 100 3
Open Elective Course – II F 3 - - 3 40 60 - - 100 3
LAB Genetic Engineering D - - 2 2 - - 25 25(OR) 50 1
LAB Mass Transfer D - - 2 2 - - 25 25(OR) 50 1
LAB Bioprocess Engineering D - - 2 2 - - 25 - 25 1
Minor Project G - - 6 6 - - 50 25(OR) 75 3
Internship - II H - - - - - - - - - -
15 - 12 27 200 300 125 75 700 21
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 4 of 69
Kavayitri Bahinabai Chaudhari
NORTH MAHARASHTRA UNIVERSITY,
JALGAON (M.S.)
Third Year Engineering
(Biotechnology Engineering)
Faculty of Science and Technology
SYLLABUS
Semester – V
W.E.F. 2020 – 21
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 5 of 69
Molecular Biology
COURSE OUTLINE
Course
Title: Molecular Biology
Short
Title: Mol Bio
Course
Code:
Course description:
This course is aimed at developing the basic knowledge and skills of molecular biology to
undergraduate students. The background expected includes a prior knowledge of SE
Biotechnology courses. The goals of the course are to understand the basic principles of
Molecular Biology and their applications in engineering trade.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 11th
, 12th
Biology, SE Biotechnology courses
Course objectives:
1. To develop the basic knowledge and skills of molecular biology. 2. To explain central dogma of molecular biology and their role in biological systems. 3. To handle the analytical techniques in molecular Biology. 4. To describe the genetic code. 5. To use the modern concepts for protein synthesis.
Course outcomes:
After successful completion of this course the student will be able to:
1. Describe basic molecular and genetic concepts and principles. 2. Communicate the fundamental concepts of molecular biology both in written and in
oral format.
3. Demonstrate nucleic acid replication and its types. 4. Critically evaluate data, develop and design experiments to address a novel problem in
the form of project.
5. Demonstrate advanced knowledge in a specialized field of molecular biology.
COURSE CONTENT
Name of the Subject: Molecular Biology Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Introduction to Genetic Material
Introduction: Nucleic acids, DNA Chemical Composition, Chargoffs Equimolar Base Ratio,
Molecular Structure of DNA, Watson and Crick Double Helical Model of DNA, forms of DNA
(B-DNA, A-DNA, C-DNA, D-DNA, E-DNA, Z-DNA)
RNA: Occurrence, types of RNA: rRNA, tRNA, mRNA. Structure of ribosome‟s. Central
Dogma, One Gene – One Polypeptide Hypothesis.
Unit–II: No. of Lectures: 08 Hours Marks: 12
DNA Replication
Replication: Overview, Basic rules and requirements of Replication, Types of DNA
replication: Generalized Model for the DNA replication, Semi conservative method of
replication, Meselson and Stahl experiment, bidirectional DNA replication, Molecular
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 6 of 69
mechanism of DNA replication, Enzymes and proteins involved in DNA replication: Structure
and functions of DNA polymerase I,II,III, primase, polynucleotide ligase, endonuclease,
helicase, single stranded binding proteins, topoisomerase, Replication Models Theta replication
model, Rolling circle Model, D-Loop Model.
Unit–III: No. of Lectures: 09 Hours Marks: 12
Transcription Transcription and Processing of RNA: Transcription, Mechanism of Transcription in
Prokaryotes, RNA polymerase of prokaryotes (structure, types and function),Transcription
Unit, Promoter Site, Molecular Mechanism of Transcription in Prokaryotes, , Molecular
Mechanism of Transcription in Eukaryotes, RNA polymerase of Eukaryotes (structure, types
and function), Transcription Factors, Eukaryotic promoters, RNA processing/Post
transcriptional modification: Introduction, processing of the pre rRNA, tRNA, and the mRNA
transcript(eukaryotic), RNA splicing (mechanism).
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Genetic Code and Protein Synthesis Genetic code: Nature and characteristics of Genetic Code, Reasons for degeneracy, Biological
Significance of Degeneracy of Genetic Code
Protein synthesis:- Mechanism of protein synthesis: Transcription Overview, Translation:
Activation of the amino acids, attachment of activated amino acids with tRNA, stages during
translation, Translation in Prokaryotes and Eukaryotes, Translocation of proteins, Post
translational processing of Proteins (Protein Folding and Biochemical Modifications)
Unit–V: No. of Lectures: 08 Hours Marks: 12
Regulation of gene expression & DNA damage and repair Gene regulation in prokaryotes, Mechanisms of gene regulation at Transcription level,
Induction and repression, Lac Operon System, Tryptophan Operon System, Gene regulation
and Translation level, Gene regulation in eukaryotes.
DNA damage and repair: Types of damages, damaging agents, repair mechanisms -
photoreactivation, dark repair, postreplicational recombination repair, SOS repair.
Text Books:
1. Veer Bala Rastogi, Fundamentals of Molecular Biology, Ane Books Pvt. Ltd 2. P.K.Gupta, Cell and Molecular Biology, Third Edition, Rastogi Publications
Reference Books:
1. Lodish et al, Molecular Biology of cell 2. Singer M and Berg P., Genes and Genomes –
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 7 of 69
Reaction Engineering
COURSE OUTLINE
Course
Title: Reaction Engineering
Short
Title: RE
Course
Code:
Course description:
The goal of the course is intended to provide a strong foundation in concepts and principles of
Chemical reactions used in bioprocess industries.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 12th
Std. Science and SE Biotechnology Courses.
Course objectives:
1. To make the student familiar with various types of reactions. 2. To understand the kinetic study of various chemical. 3. To understand the kinetic study of various biochemical reactions. 4. To design various types of reactors used in process industries. 5. To interpret the experimental data.
Course outcomes:
After successful completion of this course the student will be able to:
1. Determine the rate and order of reaction from experimental data. 2. Analyze and interpret the kinetics of reactions. 3. Apply the fundamentals of chemical reaction engineering to design different types of
reactors.
4. Explain heterogeneous system with its applications. 5. Use the various types of reactors for different types of homogeneous and heterogeneous
reactions.
COURSE CONTENT
Name of the Subject: Reaction Engineering Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 09 Hours Marks: 12
Introduction to chemical reaction engineering: Classification of chemical reactions, rate of
reaction, order and molecularity of reaction, rate constant, activation energy, transition state
theory and temperature dependency, comparison of theories, Reaction mechanism.
Unit–II: No. of Lectures: 08 Hours Marks: 12
Collection and interpretation of kinetic data, ,integral and differential method of analysis of
data, Half life method , Constant volume batch reactor ,Variable volume batch reactor.
Unit–III: No. of Lectures: 08 Hours Marks: 12
Ideal reactors, mixed flow reactor, plug flow reactor, space time and space velocity, holding
time and space time, comparison in mixed and plug flow reactors, Recycle reactor,
Autocatalytic reaction.
Unit–IV: No. of Lectures: 08 Hours Marks: 12
Residence time distribution of fluid in PFR and CSTR, Conversion directly from tracer
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 8 of 69
information, Models for non-ideal flow, Dispersion models, Concept of micro and macro
mixing.
Unit–V: No. of Lectures: 09 Hours Marks: 12
Introduction to Rate equations for heterogeneous systems , Contacting patterns in Two –Phase
system, Introduction to fluid particle reaction non-catalytic reactions, un reacted core model for
Spherical particle of unchanging size, Rate of reaction for shrinking spherical particles ,
Determination of rate controlling step ,Various contacting patterns in fluid solid reactors for
fluid-particle non-catalytic reactions.
Text Books:
1. Octave Levenspiel, Chemical reaction engineering, John Wiley and sons. 2. Scott Fogler, Elements of chemical reaction engineering, Prentice Hall New, Jersy. 3. S.D. Dawande, Principles of reaction engineering, Central Techno publication, Nagpur.
Reference Books:
1. J.M. Smith, Chemical engineering kinetics, McGraw Hill 2. Lanny D. Schimdt , Chemical reaction engineering, Oxford University Press.
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 9 of 69
Enzyme Engineering
COURSE OUTLINE
Course
Title: Enzyme Engineering
Short
Title: EE
Course
Code:
Course description:
This course is introduced for learning the basic fundamentals of Enzyme Engineering to
undergraduate students. The goals of the course are to understand the basic knowledge of
Enzymes, their classification, production, purification and Immobilization to be use in different
areas.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 12th
Std. Science and SE Biotechnology Courses.
Course objectives:
1. To accustom knowledge of enzyme & its classification & its role in metabolic pathway of living systems.
2. To get acquainted with enzyme kinetics and its application in production of desired products.
3. To design and conduct experiments to analyze and interpret enzyme kinetic data for the
design of enzyme reactor for production of value added products.
4. To get insights of various analytical techniques for characterization of enzymes.
5. To get acquainted application of enzymes in various industries used for the
manufacturing of Bioproducts for the welfare of society.
Course outcomes:
After successful completion of this course the student will be able to:
1. Classify enzymes on the basis of their working mechanism. 2. Calculate the enzyme kinetics and activity by performing various assays. 3. Characterize the enzymes by using modern equipments. 4. Immobilize enzyme by various immobilization techniques for better stability and activity
as well as to reduce their losses during use.
5. Apply molecular mechanism of various enzymes in different metabolic pathways.
COURSE CONTENT
Name of the Subject: Enzyme Engineering Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Introduction to Enzymes:
Classification, nomenclature, International units and types of enzymes, General characters of
enzymes: characters such as specificity, catalysis and regulation and localization of enzymes in
the cell, Structure of enzymes: Primary, secondary and tertiary structure of enzyme, Models of
enzyme activity: Lock and key model, Induced fit, Substrate Strain model. Isoenzyme, with
example and its application.
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 10 of 69
Unit–II: No. of Lectures: 09 Hours Marks: 12
Enzyme Kinetics:
Introduction to kinetics: activation energy, transition state theory and energy, consideration,
Enzyme kinetics, rate equation, Rate of reaction, First order and second order reaction,
Michaelis – menten equation ( Steady state kinetics ) and Haldane relationship, Significance of
Km, Lineweaver – Burk or Double – reciprocal plot, Eadie- Hofstee plot, Hanes plot, Turnover
number, Specificity constant, Bisubstrate reaction.
Unit–III: No. of Lectures: 09 Hours Marks: 12
Enzyme inhibition, its kinetics and Catalysis:
Types of inhibition- Reversible and irreversible inhibition, Kinetics of inhibition. Catalytic
efficiency- proximity and orientation effects, distortion or strain, Different mechanisms of
enzyme catalysis, acid base and covalent catalysis and metal-ion catalysis, Molecular
mechanism of action of chymotrypsin, Lysozyme, Chemical modification of enzymes,
Bisubstrate or Multisubstrate reaction: Ping – Pong mechanism, sequential mechanism.
Unit–IV: No. of Lectures: 08 Hours Marks: 12
Allosteric and regulatory enzyme, enzyme production and purification:
Binding of ligands to Protein, Co-operativity models- MWC and KNF model, Regulations by
allosteric enzymes, other mechanisms of enzyme regulation-enzyme induction and repression
and covalent modification. Sources of enzymes-animal plant and microbial sources, large scale
production of enzymes- basic methodology of production, extraction and purification of
enzymes, Enzyme production and recombinant DNA technology.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Enzyme immobilization:
Methods of immobilization - ionic bonding, adsorption, covalent bonding (based on R groups
of amino acids), and microencapsulation and gel entrapment, Properties of immobilized
enzymes, Applications of immobilized enzymes.
Enzyme Applications: Applications of enzymes in food, sugar, leather, detergent industries
etc., Uses of enzymes in drug, medicine, industries, Uses of enzymes to make amino acids and
peptides, Legislative and safety aspects.
Text Books:
1. Lehninger, Nelson and cox. Principles of Biochemistry –Macmillan publishers. 2. Palmer, Enzymes, Oxford University press.
Reference Books:
1. Voet and Voet, Biochemistry, Wiley publisher. 2. Biotol series, Principles of Cell energetics , Butterworth- Heinemann Ltd, Jordan Hill,
Oxford.
3. Murray moo-young, Comprehensive Biotechnology Pergemon Press( Vol 2 ) 4. Nicholascprice and Tewis stereous, Fundamentals of Enzymology, Oxford University press.
5. Michael L. Shuler, Fikret Kargi, Bioprocess Engineering, Basic concepts, Prentice Hall India Pvt. Ltd., New Delhi.
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 11 of 69
Professional Elective Course - I
Food Biotechnology
COURSE OUTLINE
Course
Title: Food Biotechnology
Short
Title: FBT
Course
Code:
Course description:
This course is introduced to understand the constituents of food. This course deals with the
study of microorganism present in food and the principles to control them.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- Microbiology, Unit operations and Biochemistry.
Course objectives:
1. To understand the various constituents of the foods and their role. 2. To understand the different microorganisms present and their role in causing food
spoilage.
3. To give the knowledge to students how to preserve the food. 4. To get acquainted with production of different food products. 5. To introduce to the different unit operation involved in food industry.
Course outcomes:
After successful completion of this course the student will be able to:
1. Find out the different microorganism responsible for food spoilage. 2. Distinguish different constituents of the food and their role in body. 3. Use their knowledge to preserve the food. 4. Apply their knowledge of unit operation in food industry. 5. Use the techniques, skill and modern engineering tools necessary for engineering
practice.
COURSE CONTENT
Name of the Subject: Food Biotechnology Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Food Biotechnology:
Introduction to food biotechnology, Constituents of food, the sources of dietary carbohydrates
and their functional property, the sources of protein and their functions, requirements of
vitamins, fatty acids in food.
Unit–II: No. of Lectures: 09 Hours Marks: 12
Microorganisms in Food:
Types of microorganism in food, Microbial examination of foods, Role and significance of
micro organism in foods, Factors influencing microbial activity, Food borne diseases: Food
infection, Viral infection, Food borne parasites, Food intoxication.
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 12 of 69
Unit–III: No. of Lectures: 08 Hours Marks: 12
Fermentation Processes Food Biotechnology:
Food fermentation, Important microbial culture in food industry, Fermentation of dairy
products, Fermentation for beverage, Single cell proteins, Fermentative production of
sauerkraut, Fermentation for production of vinegar and Idly.
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Food Spoilage and Preservation:
Causes of food spoilage, Spoilage of various foods and food products, Deterioration of food
quality, Food preservation using high temperature, Evaporation, Drying, Low temperature and
Irradiation.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Food Storage and Packing:
Storage and packaging of various food products like fruits and vegetables, milk and milk
products, bakery products, confectionary products & other food products.
Text Books:
1. B. Sivashankar, Food Processing and Preservation, Prentice Hall ,India. 2. Powar and Daginawala, General Microbiology (vol 2), Himalaya Publishing House.
Reference Books:
1. Murray Moo-Young, Comprehensive Biotechnology (Vol: 3), Pergamon Press, An imprint of Elsevier.
2. S.S. Purohit, Microbiology: Fundamentals and Application, Agrobios India. 3. Fraizer, Food Microbiology ,TMH publication 4. Hiller, Genetic Engineering of Food: Detection of Genetic Modifications, Willy
Publication.
5. Morries B. Jacobs, The chemical analysis of food and food products, published Van Nostrand Company Priceton New Jersey (3rd edition, 2006).
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 13 of 69
Professional Elective Course - I
System Biology
COURSE OUTLINE
Course
Title: System Biology
Short
Title: SB
Course
Code:
Course description:
This course deals with basics of system biology. It also introduces various software involved in
modeling and simulation. This course has also been dealt with various mathematical model
constructions of biological pathways.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- Biochemistry, Molecular biology, Genetics.
Course objectives:
1. To introduce the basics of both theoretical and practical aspects of system biology approach.
2. To cover the basics of mathematical modeling part of Systems Biology. 3. To describe the gene network for steady state gene expression. 4. To describe the Modular Modeling Concept and Computational Cell Biology. 5. To construct Mathematical Models of Biological Signal Transduction Pathways.
Course outcomes:
After successful completion of this course the student will be able to:
1. Apply a network biology analysis approach to a wide range of molecular biology problems.
2. Critically assess the quality of high-throughput protein-protein interaction data. 3. Apply basics of biological networks. 4. Describe basic computational methods for biological networks based on high-
throughput data.
5. Describe and apply basic algorithms.
COURSE CONTENT
Name of the Subject: System Biology Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
System Biology:
Introduction, System Structure Identification, System Behavior Analysis, System Control,
System Design, Measurement Technologies and Experimental methods, System Structure
Identification, The System Project, Impacts of System Biology.
Unit–II: No. of Lectures: 09 Hours Marks: 12
Reverse Engineering And Data Mining From Gene Expression Data:
The DBRF Method For Inferring A Gene Network From Large-Scale Steady-State Gene
Expression Data, Performance of The DBRF Method, Application To Yeast Gene Expression
Data, The Analysis of Cancer Associated Gene Expression Matrices, Automated Reverse
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 14 of 69
Engineering of Metabolic Pathways From observed data by Means of Genetic Programming.
Unit–III: No. of Lectures: 08 Hours Marks: 12
Software for Modeling And Simulation:
The ERATO Systems Biology Workbench: An Integrated Environment For Multiscale And
Multi Theoretic Simulations In Systems Biology, The Systems Biology Markup Language, The
Systems Biology Workbench, Automatic Model Generation For Signal Transduction With
Applications To MAP-Kinase Pathways, Mapk Pathway With Scaffolds: Experimental
Background, Parameter Estimation.
Unit–IV: No. of Lectures: 08 Hours Marks: 12
Cellular Simulation:
Towards A Virtual Biological Laboratory, Modular Modeling Concept, Computational Cell
Biology, The Stochastic Approach, Modeling Bacterial Chemotaxis, Computer Simulation Of
The Cell: Human Erythrocyte Model And Its Application.
Unit–V: No. of Lectures: 09 Hours Marks: 12
System-Level Analysis:
Constructing Mathematical Models of Biological Signal Transduction Pathways: An Analysis
of Robustness, Robust perfect adaptation and integral feedback control In Bacterial
Chemotaxis, Combination of Biphasic Response Regulation And Positive Feedback As A
General Regulatory Mechanism In Homeostasis And Signal Transduction, Regulation of
MAPK Concentration.
Text Books:
1. Hiroaki Kitano, Foundations of Systems Biology edited; The MIT Press Cambridge 2. Uri Alon, An Introduction to Systems Biology: Design Principles of Biological
Circuits, First edition; Chapman and Hall/CRC Publications.
Reference Books:
1. Eberhard Voit, First Course in Systems Biology; Garland Science.
2. Edda KlippSystems, Biology , Wolfram Liebermeister; First edition Wiley VCH
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
Page | 15 of 69
Professional Elective Course - I
Biothermodynamics
COURSE OUTLINE
Course
Title: Biothermodynamics
Short
Title: BTH
Course
Code:
Course description:
This course deals with basics of thermodynamics system biology. This course has also been dealt
with various mathematical model constructions.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 12th
STD
Course objectives:
1. To introduce the students with the basics of first law of thermodynamics both theoretical and practical aspects of thermodynamics.
2. To introduce the students with the basics of second law of thermodynamics both theoretical and practical aspects of thermodynamics.
3. To get familiar with the concepts of material and energy balance of the systems. 4. To understand the thermodynamic properties of fluids. 5. To explain the concepts of thermodynamic solutions.
Course outcomes:
After successful completion of this course the student will be able to:
1. Describe first and second law of thermodynamics. 2. Apply the concept of material and energy balance. 3. Discuss the thermodynamic properties of fluids. 4. Demonstrate the concept of thermodynamic properties of fluids. 5. Describe chemical concepts of ideal and non ideal solutions.
COURSE CONTENT
Name of the Subject: Biothermodynamics Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60 marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 42 marks
Unit–I: No. of Lectures: 09 Hours Marks: 12
Basic Concepts In Engineering Thermodynamics:
First and Second law of thermodynamics; Calculation of Work, energy and property
changes in reversible processes, Thermodynamics of flow processes; Power cycles and
refrigeration cycles, Residual properties
Unit–II: No. of Lectures: 08 Hours Marks: 12
Material Balance:
Steady state and equilibrium, types of material balances, stoichiometry of growth and product
formation, Electron balance, Theoretical oxygen demand
Unit–III: No. of Lectures: 09 Hours Marks: 12
Energy Balances:
Basic Energy concepts, Intensive and Extensive properties, general energy balance equations,
Enthalpy calculations, State properties-reactive and non-reactive systems, Heat of solutions, Heat
of combustion, Heat of reaction in non-standard condition; Energy balance equation for cell
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
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culture with basic numerical calculations.
Unit–IV: No. of Lectures: 08 Hours Marks: 12
Thermodynamic Properties of Fluids:
Estimation of thermodynamic properties using equations of state; Maxwell relationships and their
applications; Calculation of flow processes based on actual property changes
Unit–V: No. of Lectures: 08 Hours Marks: 12
Solution Thermodynamics:
Partial molar properties; concepts of chemical potential and fugacity Ideal non ideal
solutions; Gibbs Duhem equation; Excess properties of mixtures; Activity Coefficient -
corm position models
Text Books:
1. J M. Smith, H. C. Van Ness and M. M. Abbott. Introduction to Chemical Engineering Thermodynamics McGraw Hill.
2. P.M. Doaran, Bioprocess Engineering Principles, Academic Press,1995.
Reference Books:
1. M. D. Koretsky, Engineering and Chemical Thermodynamics, John Wiley and sons,2004.
Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.)
Syllabus for Third Year Engineering (Biotechnology) w.e.f. 2020-21
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Professional Elective Course - I
Cell Biology
COURSE OUTLINE
Course
Title: Cell Biology
Short
Title: CB
Course
Code:
Course description:
This course is introduced for learning the basic fundamentals of Life sciences to undergraduate
students. The prospectus includes a prior knowledge of Biotechnology. The goals of the course
are to understand the basic principles of Biotechnology and its applications in different areas.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 10th&12th STD Zoology, Botany.
Course objectives:
1. Students will understand the structures and purposes of basic components of prokaryotic and eukaryotic cells, especially macromolecules, membranes, and
organelles.
2. Students will understand how these cellular components are used to generate and utilize energy in cells.
3. Students will apply their knowledge of cell biology to selected examples of changes or losses in cell function. These can include responses to environmental or Physiological
changes, or alterations of cell function brought about by mutation.
4. Students will learn the basic principles of inheritance at the molecular, cellular and Organism levels.
5. Students will understand relationships between molecule/cell level phenomena (“Modern genetics”) and organism-level patterns of heredity (“classical” genetics).
Course outcomes:
After successful completion of this course the student will be able to:
1. Apply all knowledge about basic biology to all problems in molecular biology and genetics.
2. Understand the knowledge about living organisms which is main subject of molecular biology and genetics.
3. Describe the current concepts in Cell Biology, Stem Cell Biology and Development. 4. Illustrate the basic cellular processes including heredity, transcription/translation (the
central dogma), cellular replication and their role in development, physiology and
higher level biological organization.
5. Demonstrate the structure/function of the basic components of prokaryotic and eukaryotic cells including macromolecules and organelles.
COURSE CONTENT
Name of the Subject: Cell Biology Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
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Unit–I: No. of Lectures: 08 Hours Marks: 12
Cell Biology and Cell Theory:
Structural organization of life, Concepts of modern cell, history of cell, Cell theory, Structure
of cell:- Cell shape, size and cell number, Types of cells:- Prokaryotic cells and Eukaryotic
cells, Chemistry of cells.
Unit–II: No. of Lectures: 08 Hours Marks: 12
Study of Intracellular Components of Cell:
Cell organelles:-Structure & Functions of: Mitochondria, Plastids:- Chloroplast, Chromoplast,
Nucleus, Ribosomes, Golgi complex, Endoplasmic Reticulum, Endosomes, Lysosomes,
Peroxisomes. Unit–III: No. of Lectures: 08 Hours Marks: 12
Cell Division:
Cell cycle, mitosis, meiosis, genetic and biochemical approaches for the study of cell division,
mitotic cell division, cell cycle check points, meiotic cell division, embryonic cell division, cell
death, the cell cycle of cancer, central cell cycle control systems.
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Basic Concepts in Genetics:
Introduction to gene, Mendels law of segregation, Assumption involved in segregation,
physical basis of segregation, Law of Independent Assortment: - Introduction, two characters
of independent segregation, test cross of dihybrid & trihybrid, physical basis of independent
assortment, Gene vs Allele: A modified concept, fine structure of gene.
Unit–V: No. of Lectures: 09 Hours Marks: 12
Elements of Genetics:
Chromosomes:- Introduction, chromosome number, size, morphology, chemical composition
of chromosome and function, Structural chromosomal aberrations:- Introduction, origin of
structural aberrations, structure of chromosomal aberrations, variation in chromosomal number,
Mutation:- Introduction, characteristics of mutations, classification, spontaneous and induced
mutations, Population genetics:- Introduction, gene frequency, genotype frequency, gene pool.
Text Books:
1. B.D. Singh “ Genetics” Kalyani Publications. 2. P.K.Gupta“ Cell & MolegcularBiology”Rastogi Publications. 3. S.C. Rastogi“ Cell& Molecular Biology” New Age International Publications.
Reference Books:
1. C.B. Pawar“ Cell Biology” Himalaya Publications.
2. C.B. Pawar“ Cell and Molecular Biology” Himalaya Publications.
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Open Elective Course - I
Biofuel and Alcohol Technology
COURSE OUTLINE
Course
Title: Biofuel and Alcohol Technology
Short
Title: BAT
Course
Code:
Course description:
This course is aimed to develop the basic knowledge and operations of Biofuel and alcohol
technology to undergraduate students. The background expected includes a prior knowledge of
BE Biotechnology courses. The goals of the course are to understand the basic principles
biofuels production & fermentations for production of organic solvents and Biofuel production
processes and their applications in engineering trade.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- Bioprocess engineering, Fermentation technology, Biochemistry.
Course objectives:
1. To develop the basic knowledge and skills in alcohol production. 2. To develop the basic knowledge and skills in Biofuel production. 3. To understand the concepts of Renewable & Nonrenewable energy resources. 4. To classify the various types of fermentation processes. 5. To use different recycling processes for alcohol production.
Course outcomes:
After successful completion of this course the student will be able to:
1. Understand Biofuel and biomass production. 2. Critically appraise logistical issues associated with implementing large scale biofuel
and biomass energy production.
3. Perform technical, economic and environmental comparisons of various energy systems.
4. Implement the various methods of fermentations processes. 5. Illustrate the alcohol recycling & biochemistry of alcohol.
COURSE CONTENT
Name of the Subject: Biofuel and Alcohol
Technology Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Introduction to Fuel Technology: Renewable & Nonrenewable energy resources, Useful features of biofuels, Undesirable
features of biofuels, Biogas technology, Biodiesel Production, Biohydrogen production.
Unit–II: No. of Lectures: 08 Hours Marks: 12
Bioenergy from biomass:
Biomass conversion to heat and power: thermal gasification of biomass, anaerobic digestion,
Biomass conversion to biofuel: Thermochemical conversion, syngas fermentation.
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Unit–III: No. of Lectures: 08 Hours Marks: 12
Alcohol Technology:
Introduction to Alcohol Technology, Raw Material of Alcohol Industry, Storage & handling of
Raw material in detail, Study of different yeast strains used in alcohol industries, Study of yeast
production as single protein cell.
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Alcoholic Fermentations: Study of different alcoholic fermentation techniques, Batch fermentation, Continuous
fermentation, Modem techniques of Continuous fermentation, Bio still fermentation, Encillium
process Wet milling of grain for alcohol production, Grain dry milling cooking for alcohol
production, Use of cellulosic feed stocks for alcohol production, Scaling in distilleries, Fusel
oil separation.
Unit–V: No. of Lectures: 09 Hours Marks: 12
Biochemistry & Recycling of Alcohol:
Study of different recycling process, Biochemistry of alcohol production, The management of
fermentation in the production of alcohol, Alcohol distillation-The fundamental, Parameters &
affecting alcoholic fermentations, By product of alcoholic fermentation, Distillery quality
control, Alcoholometry.
Text Books:
1. B.D. Singh, Kalyani Publications. 2. Charles E Dryden; Rao, M. Gopala,; Sittig, Marshall. ,Out lines of Chemical
Technology.
Reference Books:
1. Olaf A Hougen, Kwenneth M. Watson, and Roland A Ragatz, Chemical Process Principles – Part I, Material and Energy Balances by CBS Publishers and Distributors
(1995).
2. T. P. Lyons ,Text books of alcohol tech.
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Open Elective Course - I
Bioorganic Chemistry
COURSE OUTLINE
Course
Title: Bioorganic Chemistry
Short
Title: BC
Course
Code:
Course description:
This course is aimed to develop the basic knowledge determination of molecular compounds.
The goals of the course are to understand the basics of aliphatic compounds, alkanes alkynes
etc.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):-
Course objectives:
1. To develop the basic knowledge and skills in Bioorganic compounds. 2. To identify the types of compounds. 3. To describe molecular structure of aromatic compounds. 4. To use techniques for qualitative and quantitative analysis of alcohols. 5. To demonstrate the industrial production of organic solvents.
Course outcomes:
After successful completion of this course the student will be able to:
1. Understand determination of molecular formula of organic compounds. 2. Apply the industrial level production of alcohol and carbonyl compounds. 3. Illustrate the structure of aromatic rings. 4. Perform the manufacturing process of organic solvents. 5. Demonstrate the techniques used for qualitative and quantitative analysis of alcohols.
COURSE CONTENT
Name of the Subject: Bioorganic Chemistry Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Fundamentals And Stereo Isomerism:
Fundamentals analysis- molecular weight, empirical and molecular formula determination.
Basics of optical and geometrical isomerism- sequence rules, R and S configurations, E &Z
notation, stereo isomerism of aliphatic hydrocarbons (cyclohexane and its derivatives only).
Unit–II: No. of Lectures: 09 Hours Marks: 12
Aliphatic Compounds:
Alkanes: preparation by Wurtz reaction, Kolbe electrolytic method, free radical substitution(
mechanism of halogenations), energy of activation and transition state. ALKANES: Industrial
preparation of ethylene 1,2 elimination reaction(E1 and E2 mechanism), electrophilic and free
radical additionreactions (Markonikov‟s and Anti Markanikon‟s rule), isoprene rule, rubber
vulcanization, compounding of rubber, elastemers.
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Unit–III: No. of Lectures: 08 Hours Marks: 12
Alkynes:
Industrial method of preparation of acetylene, acidity of alkynes, dines-1,2 and 1,4 addition,
diels-Alder reaction. Cyclo alkanes: preparation and properties of simple cycloalkanes, Bayer‟s
strain theory
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Aromatic compounds:
Benzene: structure of benezene, aromatic character, electrophilic aromatic
substitution(mechanism of nitration, sulphonation, halogenations, Friedel crafts alkylation and
acylation). Orientation of disubstituted benzens- activating and deactivating groups.
Arenes:preparation of arenas, clemenson and WolfKishner reductions, Arylhalides:
preparation of arylhalides by sand Meyer and Gattermann reaction, nucleophilic aromatic
substitution.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Alcohols and carbonyl compounds:
Alcohols- industrial method of preparation of ethyl alcohol, differentiation tests for primary,
secondary and tertiary alcohols, Grignard synthesis of alcohols, Ethers: preparation of ethers
and epoxides- Williamson synthesis
Text Books:
1. R.T Morrison and R.N Boyd, Text book of organic chemistry. 2. I.L Finar, Longman group publishers, A text book of organic chemistry vol.1.
Reference Books:
1. L.G.Wade, jr.,Pearson, A text book of organic chemistry. 2. Francis A. Carey, Tata, A text book of organic chemistry. Mc Graw-Hill Publication.
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Open Elective Course - I
Biomedical Instrumentation
COURSE OUTLINE
Course
Title: Biomedical Instrumentation
Short
Title: BMI
Course
Code:
Course description:
This course gives basic knowledge of the principle of operation and design of biomedical
instruments.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):- Concept of Biotechnology.
Course objectives:
1. To analyze of biological systems and the technological advancement for health care. 2. To apply in an ethically responsible manner for the good of society.
3. To demonstrate the use of variety of software used in various biomedical
instrumentations.
4. To explain basic functions of Cardiac Pacemakers and Defibrillators.
5. To use the techniques, skill and modern engineering tools.
Course outcomes:
At end of the course Student will be able to:
1. Understand principle, Working and application of biomedical instruments. 2. Analyze results related to engineering and biological problems. 3. Design variety of software used in various biomedical instrumentations. 4. Develop ability to use the techniques, skill and modern engineering tools. 5. Explore the options for biomedical instruments in higher study.
COURSE CONTENT
Name of the Subject: Biomedical
Instrumentation Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams
(ISE):
40
marks
Unit–I: No. of Lectures: 09 Hours Marks: 12
Electrode Electrolyte interface, half cell potential, Polarization, polarisable and non polarizable
electrodes, Ag/AgCl electrodes, Electrode circuit model; motion artifact. Body Surface
recording electrodes for ECG, EMG, and EEG, Internal electrodes, needle and wire electrodes,
Micro electrodes, metal microelectrodes, Electrical properties of microelectrodes, Electrodes
for electric stimulation of tissue.
Unit–II: No. of Lectures: 08 Hours Marks: 12
Vascular Systems:
Cardiovascular systems, Physiology of heart, ECG lead configuration, Blood Pressure
Characteristics of blood flow, Measurement of blood flow and cardiac output.
Unit–III: No. of Lectures: 09 Hours Marks: 12
Biophysical Techniques:
Function of kidneys, Artificial kidney, Dialysers, Membranes for Heamo-dialysis Heamo-
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dialysis Machine, Portable kidney machine, Mechanics of respiration Artificial ventilation,
ventilators Types, ventilator terms, classification of ventilators Modern ventilators, HF
ventilators, Nebulisers and Aspirators.
Unit–IV: No. of Lectures: 08 Hours Marks: 12
Cardiac Pacemakers and Defibrillators:
Need for pacemakers, external pacemakers, and Implantable pacemakers, recent developments,
pacing system analyzer, need for defibrillators, DC defibrillators, Implantable defibrillators,
and Defibrillators analyzers, measurement of blood PCO2.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Nervous System:
Nervous system ,Classification of Nervous system, Anatomy of Nervous system, Organization
of Brain Neuronal communication, Neuronal receptors, Somatic and Autonomic nervous
system Spinal reflexes ., Neuronal firing measurements, EEG measurement.
Text Books:
1. Cromwell - Biomedical Instrumentation, Pearson / PHI. 2. Khandpur - Handbook of Biomedical Instrumentation
Reference Books:
1. Vander, Sherman, Human Physiology. The Mechanism of Body Function, TMH Ed.1981
2. Carr & Brown Introduction To Biomedical Equipment Technology
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Open Elective Course - I
Energy Engineering
COURSE OUTLINE
Course
Title: Energy Engineering
Short
Title: EE
Course
Code:
Course description:
Energy engineering aims to give students real-world technical expertise in strategic renewable
energy disciplines, as well as an in depth understanding of the issues associated with
renewable energies and their development, including the short and medium-term technical,
technological, geopolitical and environmental challenges.
Lecture
Hours/week No. of
Weeks
Total hours Semester credits
03 14 42 03
Prerequisite course(s):-
Engineering Chemistry, physics and Mathematics.
Course objectives:
1. To impart introduction to energy engineering. Energy resources and forms of energy. 2. To study about Conventional Energy Sources like Coal and types of coal and
byproduct, Petroleum, Natural gas and Refinery Products.
3. To study about solar energy, wind energy, geothermal, tidal energy, Bio energy. 4. To impart the knowledge of Chemical Energy Sources- Fuel cell, Hydrogen,
Methanol, Nuclear energy.
5. To give the knowledge of Energy conversion processes and devices, Power plants
with conventional energy sources.
Course outcomes:
At end of the course Student will be able to:
1. Apply knowledge of mathematics, science, and engineering to various processes, 2. Analyze and interpret the data. 3. Understand the conventional and nonconventional source of energy. 4. Explain the National energy strategy and energy plans, energy power management. 5. Describe the energy audit, various energy conversion processes, devices and about the
power plants.
COURSE CONTENT
Name of the Subject: Energy Engineering Semester: V
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Energy engineering and energy technology: Law of conservation of Energy, Generalized
equation of Energy conservation, Energy resources and forms of energy, Energy demand,
Changing energy consumption trends, National energy strategies of India, Crucial Issue
in India‟s energy planning. Energy power management and Energy planning in India.
Energy Audit- Types of Energy Audits Conservation and recycling.
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Unit–II: No. of Lectures: 09 Hours Marks: 12
Conventional Energy Sources: Coal: Type of coal, classification of Indian coal. Important Properties of coal.
Exploration, Coal Preparation, Removal of sulphur, Storage and Transportation of coal.
Coal gasification, coal liquefaction. Petroleum, Natural gas and Refinery Products:
Introduction to Petroleum and Natural gas and Naphtha. Exploration of petroleum.
Production of crude oil and Natural gas. Transportation of crude oil and Natural gas. Refining
of crude oil and Natural gas Refinery. Liquefaction of Natural gas
Unit–III: No. of Lectures: 08 Hours Marks: 12
Chemical Energy Sources:
Fuel cells: Introduction, Design and operation of aFuel cell. Classification of fuel cells: Types
of fuel cells, Advantages and disadvantages of fuel cells, Applications of fuel cells.
Hydrogen: Introduction, Applications of Hydrogen, Production of Hydrogen, Storage and
transportation safety and management, Hydrogen technology development in India.
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Nuclear Energy:
Nuclear energy and application compared with coal, Fuels for Nuclear Fission
Reactor. Storage and Transportation. Energy from Nuclear fission reactor. Fast breeder
Reactor. Boiling water reactor. Pressurized heavy and Light Water reactor. Uranium
Enrichment Process. Nuclear Waste Management.
Solar Energy:
Terms and definition ,units. Application of solar heater solar energy storage, Thermal storage,
battery storage. Applications of Solar energy. Wind energy: Basic Principles of wind energy
conversion. Site Selection Considerations. Classification of wind energy conversion
system, Wind power density, Power in wind stream, Forces on the blades of a
propeller, Energy pattern factor, Definition of wind speed for Turbines.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Bio energy:
Biomass energy resources, Biomass conversion processes, direct combustion of biomass,
Thermo chemical conversion of biomass, Biochemical conversion, Ethanol from biomass,
Applications, Biodiesel. Energy conversion technologies and Electrical powerplants: Power
plants with conventional energy sources, Coal fired steam thermal power plants, Combined
cycle power plants, Integrated coal gasification combined cycle power plants, Plant factors
and reserves.
Text Books:
1. S. Rao and Dr. B.B. Parulekar, “Energy Technology” Non Conventional, Renewable and Conventional, Khanna Publishers, New Delhi.
2. G.D. Rai “Non conventional Energy Sources”, Khanna Publishers,New Delhi.
Reference Books:
1. S.B. Pandya, “Conventional Energy Technology” Fuelsand Chemical Energy Tata McGrawHill Publishing Company Ltd, New Delhi
2. S.P. Sukhatme, “Solar Energy”, Principals of thermal collection and Storage. Tata McGrawHill Publishing Company Ltd, New Delhi
3. Thipse, S. S. “ Alternative fuels” Jaico Publishing House; First edition , 2010 4. OP Gupta, Energy Technology, Khanna Book Publishing Co. (P) Ltd., Delhi 2. 5. Chakrabarti A ,Energy Engineering & Management, PHI
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Lab Molecular Biology
LAB COURSE OUTLINE
Course
Title: Lab Molecular Biology
Short
Title:
Lab Mol
Bio Course
Code:
Course description:
In this laboratory, course emphasis is on the understanding of basics of Molecular Biology
techniques. The learner can use this knowledge and apply in allied branches of Biotechnology
as required.
Laboratory Hours/week No. of weeks Total hours Semester credits
02 14 28 01
End Semester Exam (ESE) Pattern: Practical (OR)
Prerequisite course(s):- 11th, 12th Biology, SE Biotechnology courses
Course objectives:
1. To impart the fundamental knowledge of molecular biology at the research level to the students.
2. To develop their ability to apply the specific procedures to analyze the experimental results.
3. To get familiar with the molecular Biology lab techniques which they can apply in research.
4. To develop lab protocols to perform gene expression at in vitro level. 5. Identify the separated nucleic acids qualitatively and quantitatively
Course outcomes:
After successful completion of lab Course, student will be able to:
1. Isolate the genetic material e.g. DNA & RNA from different cells. 2. Calculate molecular weight by using DNA marker with agarose gel electrophoresis 3. Extract of chromosomal DNA from onion cells 4. Determine the melting temperature (Tm) and base composition of DNA from thermal
denaturation characteristics.
5. Quantify Nucleic acids.
LAB COURSE CONTENT
Lab Molecular Biology Semester: V
Teaching Scheme: Examination scheme
Practical: 2 hours/week End semester exam (ESE): 25
marks
Internal Continuous Assessment
(ICA):
25
marks
List of Experiments (Note: Minimum Eight Experiments from the following)
1. Isolation of genomic DNA from bacteria. 2. Isolation of RNA from yeast. 3. Isolation of total plasmid DNA from bacteria. 4. Calculation of molecular weight by using DNA marker with agarose gel
electrophoresis.
5. DNA extraction from blood. 6. Spooling of chromosomal DNA from onion cells. 7. Determination of melting temperature (Tm) and base composition of DNA from
thermal denaturation.
8. Isolation of genomic DNA from plant material. 9. Isolation of genomic DNA from yeast.
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Text Books:
1. David Plummer, Introduction to Practical Biochemistry, Third Edition. 2. S. Sadasivam, A. Manickam, Biochemical Methods, Second Edition, New Age
International Ltd, Publishers.
Guide lines for ICA:
Students must submit ICA in the form of journal. Each practical should be well documented.
Faculty in charge will assess the practical continuously and grade or mark each practical on
completion date declared for each practical.
Guidelines for ESE:
ESE will be based on the oral examination of laboratory experiments submitted by the students
in the form of journal.
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Lab Reaction Engineering
LAB COURSE OUTLINE
Course
Title: Lab Reaction Engineering
Short
Title: Lab RE
Course
Code:
Course description:
The goal of the Lab course is intended to provide a strong foundation in concepts and
principles of Chemical reactions used in bioprocess industries.
Lecture Hours/week No. of weeks Total hours Semester credits
Laboratory 02 14 28 01
End Semester Exam (ESE) Pattern: Oral (OR)
Prerequisite course(s): 12th
Std. Science and SE Biotechnology Courses.
Course objectives:
1. To impart the fundamental knowledge of Chemical reaction engineering to the students.
2. To develop their ability to apply the specific procedures in industries. 3. To analyze the experimental results. 4. To apply absorption and adsorption processes for heterogeneous systems. 5. To analyze & interpret data obtained during performance of the experiment
Course outcomes:
Upon successful completion of lab Course, student will be able to:
1. Understand the kinetic study of various chemical and biochemical reactions used in process industries
2. To design various types of Reactors. 3. Demonstrate an ability to use the techniques, skills, and modern engineering tools
necessary for engineering practice.
4. Demonstrate the understanding of professional and ethical responsibilities. 5. Understand the environmental issues and to provide solutions for green and clean
technologies
LAB COURSE CONTENT
Lab Reaction Engineering Semester: V
Teaching Scheme: Examination scheme
Practical: 2 hours/week End semester exam (ESE): 25
marks
Internal Continuous Assessment
(ICA):
25
marks
List of Experiments (Note: Minimum Eight Experiments from the following)
1. To determine the reaction rate constant {k} for given reaction.( CSTR / BATCH / SEMIBATCH / PFR )
2. To determine the effect of temperature on reaction rate constant. .( CSTR / BATCH / SEMIBATCH / PFR )
3. To determine the activation energy {E} for the given reaction. .( CSTR /BATCH / SEMIBATCH / PFR )
4. To draw C [t], E [t] and F [t] curve and to calculate the mean residence time {tm} variance { σ2} and skewness { S3} for plug flow reactor.
5. To draw C [t], E [t] and F [t] curve and to calculate the mean residence time {tm} variance {σ2} and skewness{S3} for annular reactor.
6. To draw C [t], E [t] and F [t] curve and to calculate the mean residence time {tm}
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variance {σ2} and skewness {S3} for packed Bed reactor.
7. To study the cascade CSTR. 8. To study the kinetic in tubular flow reactor [coiled tube] for the given reaction.
Text Books:
1. H. Scott Fogler, Elements of chemical reaction engineering, Prentice Hall New, Jersy. 2. 2. Octave Levenspiel, Chemical reaction engineering, John Wiley and sons.
Guide lines for ICA:
Students must submit ICA in the form of journal. Each practical should be well documented.
Faculty in charge will assess the practical continuously and grade or mark each practical on
completion date declared for each practical.
Guidelines for ESE:
ESE will be based on the oral examination of laboratory experiments submitted by the students
in the form of journal.
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Lab Pharmaceutical Biotechnology
LAB COURSE OUTLINE
Course
Title: Lab Pharmaceutical Biotechnology
Short
Title: Lab PBT
Course
Code:
Course description:
In this laboratory, course emphasis is on the understanding of basics techniques of
pharmaceutical processes. The learner can use this knowledge and apply in allied branches of
Biopharmaceutical and Biotechnology as required.
Lecture Hours/week No. of weeks Total hours Semester credits
Laboratory 02 14 28 01
End Semester Exam (ESE) Pattern: Oral (OR)
Prerequisite course(s): Microbiology, Bioprocess Engineering.
Course objectives:
1. To impart the fundamental knowledge of pharmaceutical processes at the research level. 2. To develop their ability to apply the analytical techniques for interpreting experimental
results.
3. To Estimate the antimicrobial assay of antibiotic, introduction to zone of inhibition and calculation.
4. To Study Immobilization of enzymes/cells by calcium alginate/gelatin/agar. 5. To Determination of thermal death time and thermal death point.
Course outcomes:
Upon successful completion of lab Course, student will be able to:
1. Isolate the microbes by air microbiology: solid and liquid impingement methods. 2. Apply the use coliform count of water by MPN technique. 3. Identify the sterility as per IP. 4. Explain the functions of selective media: McConkey Agar, Cetrimide Agar, Vogel
Johnson, Salt mannitol agar.
5. Study various immunology and biochemical test.
LAB COURSE CONTENT
Lab Pharmaceutical Biotechnology Semester: V
Teaching Scheme: Examination scheme
Practical: 2 hours/week End semester exam (ESE): 25
marks
Internal Continuous Assessment
(ICA):
25
marks
List of Experiments (Note: Minimum Eight Experiments from the following)
1. Air microbiology by solid and liquid impingement methods. 2. Coliform count of water by MPN technique. 3. Test for sterility as per IP (Injection water/ nonabsorbent cotton/soluble powder/ear
drops).
4. Microbial limit test on excipients as per I.P. – Hard gelatin, tragacanth, starch, lactose 5. Studies on selective media: McConkey Agar, Cetrimide Agar, Vogel Johnson, Salt
mannitol agar.
6. Antibiotic sensitivity test by disc method. 7. Widal test tube agglutination method. 8. Biochemical tests (Catalase, Oxidase, Urease, Nitratase, Protease, Amylase and
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IMVIC).
9. Antimicrobial assay of antibiotic, introduction to zone of inhibition and calculation. 10. Immobilization of enzymes/cells by calcium alginate/gelatin/agar. 11. Isolation of DNA. 12. Selection and isolation of bacteria by replica plating. 13. Determination of thermal death time and thermal death point. 14. Effect of Ultra-Violet exposure on growth of E coli. 15. Demonstration of electrophoresis either by PAGE or Agarose gel electrophoresis.
Text Books:
1. Kanai L. Mukherjee, Medical Laboratory Technology: A Procedure Manual for Routine Diagnostic Tests Tata McGraw Hill Publishing Company Ltd., New Delhi.
2. Desmond S. T. Nicholl, An Introduction to GENETIC ENGINEERING, 2nd Edition, Cambridge University Press.
3. Wulf Crueger & Anneliese Crueger, Panima, Biotechnology: A Textbook of Industrial
Microbiology, 2nd Edition, Publishing Corporation, New Delhi/Bangalore.
Guide lines for ICA:
Students must submit ICA in the form of journal. Each practical should be well documented.
Faculty in charge will assess the practical continuously and grade or mark each practical on
completion date declared for each practical.
Guidelines for ESE:
ESE will be based on the oral examination of laboratory experiments submitted by the students
in the form of journal.
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Minor Project (Stage – I)
LAB COURSE OUTLINE
Course
Title:
Minor Project (Stage – I) Short
Title:
MPROJ-
S-I
Course
Code:
Course description:
Minor project represent the culmination of study towards the Bachelor of Engineering degree. The
minor project offers the opportunity to apply and extend material learned throughout the program. The
emphasis is necessarily on facilitating student learning in technical, project management and
presentation spheres.
Laboratory Hours/week No. of weeks Total hours Semester credits
6 14 84 3
End Semester Exam (ESE) Pattern: ----
Prerequisite course(s):
Course objectives:
1. To understand the basic concepts & broad principles of projects. 2. To understand the value of achieving perfection in project implementation & completion. 3. To apply the theoretical concepts to solve problems with multidisciplinary approach. 4. To demonstrate professionalism with ethics. 5. To present effective communication skills and relate engineering issues to broader societal
context.
Course outcomes:
Upon successful completion of lab Course, student will be able to:
1. Demonstrate a sound technical knowledge of their selected project topic. 2. Undertake problem identification, formulation and solution. 3. Design engineering solutions to complex problems utilizing a systems approach. 4. Conduct an engineering project. 5. Demonstrate the knowledge, skills and attitudes of a professional engineer.
LAB COURSE CONTENT
Minor Project (Stage – I) Semester: V
Teaching Scheme: Examination scheme:
Practical: 6 hours/week Internal Continuous Assessment
(ICA):
50 marks
At third year the students shall carry out a minor project in a group of maximum up to 5
students. The project work spans both the semesters. By the end of Semester – V the students
shall complete the partial work, and by the end of Semester – VI the students shall complete
remaining part of the project. Assessment for the project shall also include presentation by the
students. Each teacher can guide maximum 04 groups of minor projects.
The students should take project work, as specified in the curriculum, based on the
knowledge acquired by the students during the degree course till Semester – IV. The
project may be either fully theoretical/practical or involving both theoretical and practical
work to be assigned by the Department. The work may also be Study/Survey/Design.
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Minor Project (Stage – I) may involve literature survey, problem identification, design
methodology, collection of data etc. The project work shall involve sufficient work so that
students get acquainted with different aspects of design and analysis. Approximately more than
50% work should be completed by the end of Semester – V. Each student group should
submit partial project report in the form of thermal bound at the end of Semester –V.
Each student group is required to maintain separate log book for documenting various activities
of the project.
Suggestive outline for the partial project report is as follows.
Abstract
Chapter 1. Introduction
Chapter 2. Project Planning and Literature Survey
Chapter 3. Methodology
Chapter 4. Implementation and Analysis
Chapter 5. Testing
Chapter 6. Result and Discussion
Chapter 7. Conclusion & Future Work
Bibliography
Index
Appendix
Guide lines for ICA:
The Internal Continuous Assessment (ICA) for project shall be based on continuous evaluation
of students‟ performance, active participation, knowledge / skill acquired throughout semester
and presentation by the students. The assessment shall be done jointly by the guide and
departmental committee. A three-member departmental committee including guide, appointed
by Head of the department, shall be constituted for the assessment. The assessment for Minor
Project (stage – I) in Semester – V shall be as per the guidelines given in Table – A.
Table – A Assessment by Guide Assessment by Departmental
Committee
Sr. No.
Name of the
Student
Attendance / Participation
Problem Identification /
Project
Objectives
Literature Survey
Methodology / Design
Report Depth of Understanding
Presentation Total
Marks 5 5 5 5 5 10 15 50
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Constitution of India
Basic features and fundamental principles:
The Constitution of India is the supreme law of India. Parliament of India cannot make any law
which violates the Fundamental Rights enumerated under the Part III of the Constitution. The
Parliament of India has been empowered to amend the Constitution under Article 368,
however, it cannot use this power to change the “basic structure” of the constitution, which has
been ruled and explained by the Supreme Court of India in its historical judgments. The
Constitution of India reflects the idea of “Constitutionalism” – a modern and progressive
concept historically developed by the thinkers of “liberalism” – an ideology which has been
recognized as one of the most popular political ideology and result of historical struggles
against arbitrary use of sovereign power by state. The historic revolutions in France, England,
America and particularly European Renaissance and Reformation movement have resulted into
progressive legal reforms in the form of “constitutionalism” in many countries. The
Constitution of India was made by borrowing models and principles from many countries
including United Kingdom and America.
The Constitution of India is not only a legal document but it also reflects social, political and
economic perspectives of the Indian Society. It reflects India‟s legacy of “diversity”. It has
been said that Indian constitution reflects ideals of its freedom movement, however, few critics
have argued that it does not truly incorporate our ancient legal heritage and cultural values. No
law can be “static” and therefore the Constitution of India has also been amended more than
one hundred times. These amendments reflect political, social and economic developments
since the year 1950. The Indian judiciary and particularly the Supreme Court of India has
played an historic role as the guardian of people. It has been protecting not only basic ideals of
the Constitution but also strengthened the same through progressive interpretations of the text
of the Constitution. The judicial activism of the Supreme Court of India and its historic
contributions has been recognized throughout the world and it gradually made it “as one of the
strongest court in the world”.
Course content
1. Meaning of the constitution law and constitutionalism
2. Historical perspective of the Constitution of India
3. Salient features and characteristics of the Constitution of India
4. Scheme of the fundamental rights
5. The scheme of the Fundamental Duties and its legal status
6. The Directive Principles of State Policy – Its importance and implementation
7. Federal structure and distribution of legislative and financial powers between the Union and
the States
8. Parliamentary Form of Government in India – The constitution powers and status of the
President of India
9. Amendment of the Constitutional Powers and Procedure
10. The historical perspectives of the constitutional amendments in India
11. Emergency Provisions: National Emergency, President Rule, Financial Emergency
12. Local Self Government – Constitutional Scheme in India
13. Scheme of the Fundamental Right to Equality
14. Scheme of the Fundamental Right to certain Freedom under Article 19
15. Scope of the Right to Life and Personal Liberty under Article 21
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Kavayitri Bahinabai Chaudhari
NORTH MAHARASHTRA UNIVERSITY,
JALGAON (M.S.)
Third Year Engineering
(Biotechnology Engineering)
Faculty of Science and Technology
SYLLABUS
Semester – VI
W.E.F. 2020 – 21
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Genetic Engineering
COURSE OUTLINE
Course
Title: Genetic Engineering
Short
Title: GE
Course
Code:
Course description:
This course is introduced for learning the basic fundamentals of Genetic Engineering to
undergraduate students. The goals of the course are to understand the basic knowledge of
Genetics, different enzymes used to engineer the genes, rDNA technology, and applications of
rDNA technology.
Lecture Hours/week No. of Weeks Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 12th
Std. Science and SE Biotechnology Courses.
Course objectives:
1. To provide the basic knowledge of Genetics. 2. To explain the role of different types of enzyme in genetic engineering studies. 3. To demonstrate the mechanism of rDNA technology, and its applications. 4. To classify the various techniques of gene sequencing. 5. To use the various types of genetic/molecular markers in genetic research.
Course outcomes:
After successful completion of this course the student will be able to:
1. Apply the knowledge of rDNA technology for the construction of novel gene for the better use with wide functionality.
2. Use various vector systems to study functionality of inserted gene. 3. Demonstrate various techniques in gene sequencing. 4. Apply the knowledge of genetics for human welfare in disease diagnosis, in criminal
cases as well as pharmaceuticals for drug designing and development.
5. Explain mechanism of molecular markers that are used in genetic engineering study.
COURSE CONTENT
Name of the Subject: Genetic Engineering Semester: VI
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 08 Hours Marks: 12
Recombinant DNA technology:
The recombinant DNA concept, Important Discoveries, Principles of cloning, Biohazards and
Bioethics of Genetic Engineering.
Unit–II: No. of Lectures: 09 Hours Marks: 12
The Tools: Enzymes:
Nucleases, The Restriction Endonucleases Type I, II, III, star activity, isoschizomers
Phosphodiesterase, Polynucleotidekinase, DNAligase, DNApolymeraseI, Reversetranscriptase,
Terminal deoxynucleotidyl transferase, Poly A polymerase.
Unit–III: No. of Lectures: 09 Hours Marks: 12
The Tools: Vector Systems:
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E coli systems – the host cells , E. coli – Plasmid Vectors , E .coli – Bacteriophage vectors , E.
coli systems –Plasmid-Phage combination vectors , Other Prokaryotic Host-Vector systems ,
Eukaryotic Host-Vector Systems:
Yeast, Eukaryotic Host-Vector Systems: Animals, Eukaryotic Host-Vector Systems: Plants.
Unit–IV: No. of Lectures: 08 Hours Marks: 12
Molecular research procedures:
DNA sequencing techniques PCR, Blotting Techniques, Gene silencing techniques, RNAi,
Knockout Technology, SAGE.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Significance of rDNA technology and Human Welfare:
Gene therapy, Restriction fragment length polymorphism (RFLPs), Random amplified
polymorphic DNA (RAPD), SNPs, AFLP, microarray, DNA fingerprinting.
Text Books:
1. Benjamin Lewin, Benjamin Cummings; Genes VIII, United States edition. 2. R.C.Dubey, Textbook of Biotechnology, S. Chand & Co. P Ltd, New Delhi.
Reference Books:
1. B.D.Singh, Textbook of Biotechnology, Kalyani Publication. 2. U.Satyanarayana, Textbook of Biotechnology , Books and Allied Pvt.Ltd. 3. Genes and Genomes – Singer M and Berg P.
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Mass Transfer
COURSE OUTLINE
Course
Title: Mass Transfer
Short
Title: MT
Course
Code:
Course description:
The goal of the course is intended to provide a strong foundation in concepts and principles of
mass transfer operations used in industries.
Lecture Hours/week No. of Weeks Total hours Semester credits
03 14 42 03
Prerequisite course(s):- 12th
Std. Science and SE Biotechnology Courses.
Course objectives:
1. To understand the basic principles of separation techniques. 2. To design various mass transfer equipments. 3. To identify the appropriate criteria for selection among alternative separation
technologies
4. To improve yield and purity of various products in process industries. 5. To describe the various types of separation techniques.
Course outcomes:
After successful completion of this course the student will be able to:
1. Demonstrate the knowledge of various mass transfer operations and its application in process industries.
2. Explain & apply knowledge of different separation techniques in downstream processing.
3. Apply appropriate criteria for selection among alternative separation technologies. 4. Increase yield and purity of various products in process industries by applying
knowledge.
5. Ability to analyze and design mass transfer equipments.
COURSE CONTENT
Name of the Subject: Mass Transfer Semester: VI
Teaching Scheme: Examination scheme
Lectures: 3 hours/week End semester exam (ESE): 60
marks
Duration of ESE: 03 hours
Internal Sessional Exams (ISE): 40
marks
Unit–I: No. of Lectures: 09 Hours Marks: 12
Introduction to mass transfer: Equilibrium for mass transfer process: Local two phase mass transfer. Local overall mass
transfer coefficient, Use of local overall coefficient. Material balances for steady state co
current, countercurrent, cross flow cascade, counter flow cascade.
Introduction to mass transfer operations, Steady state molecular diffusion in fluid at rest, Multi
component mixture diffusion, Maxwell‟s law of diffusion. Diffusion in solids, Unsteady state
diffusion. Mass transfer coefficient in laminar and turbulent flow Theories of mass transfer.
Unit–II: No. of Lectures: 08 Hours Marks: 12
Distillation:
Introduction to distillation process, Vapor liquid equilibrium, The methods of distillation
(Binary mixture), The fractionating column, McCabe Thiele & Lewis Sorel method, Batch
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distillation, Azeotropic, extractive and steam distillation.
Unit–III: No. of Lectures: 08 Hours Marks: 12
Extraction & Leaching:
Introduction to extraction process, Liquid equilibria, Material balances for stage wise contact
methods, Stage contact and continuous contact type extractors. Leaching: General principles of
leaching, working principle of moving-bed leaching equipments: Bollman extractor,
Hildebrandt extractor.
Unit–IV: No. of Lectures: 09 Hours Marks: 12
Adsorption and ion exchange operation:
Introduction to adsorption operation, Type of adsorption operation, Nature of adsorbents,
Adsorption equilibria, Adsorption of liquids, Material balances for stage wise for operation,
Continues contact process for adsorption, Principle of ion exchange operation, Rate of ion
exchange operation, Application of ion exchange operation.
Unit–V: No. of Lectures: 08 Hours Marks: 12
Crystallization and Drying:
Introduction to crystallization, Effect of impurities in crystallization, Effect of temperature on
solubility, Caking and yield of crystals, Different type of crystallizers. Introduction to Drying
operation: Rate of drying, Mechanism of moisture movement during drying, Drying
equipments, Different methods of drying.
Text Books:
1. R. E. Treybal , Mass transfer operation ,McGraw Hill Publication 2. Coulson and Richardson Chemical Engineering (Vol. I and II), Pergamon Press
Reference Books:
1. Christie J. Geankoplis ,Transport Processes and Unit Operations ,Prentice Hal inc 2. P. Chattopadhayay , Unit operation in Chemical Engg. (Vol. I and II), Khanna
Publications Delhi.
3. B.K. Dutta, Principles of Mass Transfer and Separation Processes, PHI Publication .
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Bioprocess Engineering
COURSE OUTLINE
Course
Title: Bioprocess Engineering
Short
Title: BPE
Course
Code:
Course description:
This course is aimed at i