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pEm
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bolA
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def
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cydA
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glnQ mtn
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yebC yffS
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−2500
−2000
−1500
−1000
−500
0
500
1000
1500
cspE
mal
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yeaG hisJ ilvB
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fabD
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01)
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.001
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01)
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01)
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.001
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01)
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04)
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01)
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05)
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27)
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12)
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.001
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accC
pyrC
(p=0
.008
)po
xB (p
=0.0
06)
tsf (
p<0.
001)
fklB
(p<0
.001
)cs
pCgl
nB (p
<0.0
01)
rplS
(p=0
.005
)se
rA (p
=0.0
09)
ptsH
rpsP
(p=0
.003
)ya
jGah
pCde
oB (p
<0.0
01)
secB
(p<0
.001
)m
etC
(p<0
.001
)m
inE
(p=0
.004
)rp
lAda
cC (p
=0.0
02)
yrbA
purM
mre
B (p
<0.0
01)
yqjG
(p=0
.023
)rp
lF (p
=0.0
05)
yceI
(p<0
.001
)rp
sQ (p
<0.0
01)
rpsE
(p=0
.018
)ar
tJpg
i (p<
0.00
1)da
pD (p
<0.0
01)
hem
Brp
lMrp
lQpp
iAel
bB (p
<0.0
01)
rpm
D (p
=0.0
19)
ybiS
rpsG
rplI
(p<0
.001
)he
mL
(p<0
.001
)w
rbA
aroG
(p<0
.001
)pa
nC (p
=0.0
02)
gpm
Adk
gByg
iN (p
=0.0
01)
pykA
(p<0
.001
)po
lA (p
=0.0
08)
nusB
(p=0
.001
)frm
Ayh
bS (p
<0.0
01)
proC
tktA
(p<0
.001
)na
gB (p
=0.0
07)
rpsR
(p=0
.025
)yh
dH (p
=0.0
1)rp
lY (p
<0.0
01)
ydcS tktB
yhbY
(p=0
.003
)gr
pE (p
=0.0
02)
osm
Ypg
lps
tSye
eXly
sS (p
<0.0
01)
pykF
(p=0
.019
)yq
cA (p
<0.0
01)
yggE
potD
panB
(p=0
.012
)cl
pP (p
<0.0
01)
rpoZ
(p<0
.001
)yd
cLde
gQrp
sJ (p
=0.0
22)
atpD
(p<0
.001
)po
tFta
lB (p
<0.0
01)
ydhF ytfQ
met
Krp
lL (p
<0.0
01)
bcp
(p=0
.004
)ga
lU (p
=0.0
14)
rbfA
(p<0
.001
)fb
aA (p
=0.0
02)
oppA
(p<0
.001
)ef
p (p
=0.0
03)
glnA
yhhW
(p<0
.001
)bt
uE livJ
rplV
gnd
(p<0
.001
)pr
oS (p
<0.0
01)
ybfF
rho
(p<0
.001
)in
fApu
rA (p
=0.0
01)
ydeN
lpcA
(p<0
.001
)m
anA
(p<0
.001
)hc
hAgr
oLas
pC (p
=0.0
03)
dhaK
(p<0
.001
)ss
pA (p
<0.0
01)
ydcH
pepD
(p<0
.001
)yc
hNde
oC (p
<0.0
01)
rfaD
(p<0
.001
)rp
sO (p
=0.0
19)
uxuA
purR
yggX
(p=0
.002
)ga
lFm
oaB
rpm
C (p
<0.0
01)
fabA
gltX
(p<0
.001
)gu
aB (p
=0.0
01)
ydbC
rpsF
(p<0
.001
)py
rIus
pApu
rCyf
iDtp
iAac
eApt
a (p
=0.0
03)
ydfG
(p<0
.001
)ga
pApp
a (p
=0.0
02)
ppiC
(p<0
.001
)fk
pA (p
<0.0
01)
udp
adk
(p=0
.01)
osm
Fih
fArp
iA (p
=0.0
04)
ybaY
cysK
(p=0
.001
)se
rC (p
<0.0
01)
ydhR
(p=0
.022
)za
pB (p
=0.0
01)
ftnA
lsrB
yahO
yahK
hinT
(p<0
.001
)trx
Bhu
pA (p
<0.0
01)
mdh
(p<0
.001
)gr
oSed
a (p
<0.0
01)
yciI
(p=0
.005
)rib
E (p
<0.0
01)
ydcF
hdeB
eno
(p=0
.019
)pp
iByg
iWrr
aB (p
=0.0
28)
pgk
(p=0
.001
)de
gP (p
<0.0
01)
acpP cd
dyc
aCyd
gH (p
<0.0
01)
greA
(p=0
.004
)yi
eF (p
<0.0
01)
upp
(p<0
.001
)pu
rEhn
s (p
=0.0
04)
yaeH
uspG
yihD
(p<0
.001
)as
nS (p
<0.0
01)
osm
Cga
dA yifE
sodA
fabI
(p<0
.001
)cr
r (p=
0.00
3)tp
x (p
<0.0
01)
ygaU yciF
ndk
tufA
(p=0
.001
)ya
jQrp
sUgn
sB (p
=0.0
06)
rpm
H (p
=0.0
03)
yjbJ
rpsT
Cov
aria
nce pm
−200
.3
−201
−201
.2
−205
.3
−207
.6
−207
.8
−209
.6
−210
.3
−210
.5
−210
.7
−212
.2
−213
−214
.4
−215
.3
−216
.5
−217
.3
−217
.8
−218
−218
.1
−219
.6
−220
−220
.2
−220
.8
−222
.4
−223
.3
−226
.2
−226
.7
−228
.4
−231
.4
−231
.8
−232
.9
−234
.8
−237
.3
−239
.1
−239
.6
−243
.8
−248
.2
−250
.4
−250
.6
−252
.6
−253
−255
.2
−255
.6
−258
.7
−258
.8
−260
.2
−262
.8
−273
.3
−273
.6
−273
.8
−273
.9
−274
.6
−277
.6
−281
−283
.3
−284
−284
.8
−287
.5
−287
.6
−289
.4
−292
.1
−292
.5
−296
.3
−296
.9
−297
.7
−311
.9
−313
.3
−315
.2
−322
.9
−323
.8
−327
.7
−328
.4
−328
.7
−330
.8
−331
.9
−342
.9
−343
.3
−345
.7
−351
.7
−352
.4
−362
.9
−371
.8
−373
.1
−394
.1
−396
.1
−400
.8
−400
.9
−406
.7
−414
.6
−465
.8
−466
−466
.7
−468
.1
−469
.1
−477
.8
−482
−493
.1
−497
.4
−510
.6
−518
.7
−518
.8
−540
−543
.5
−570
.5
−572
.9
−579
.6
−622
.7
−662
.5
−699
.3
−704
.1
−730
.1
−741
.7
−140
5.6
Data S1 Covariance analysis of control of protein concentrations for all genes with quantified mRNA and protein. Refer to Fig. 2A legend for details.Additionally, mRNA and protein expression burden (CovariancemRNA and Covarianceprotein, respectively) with increasing μ are shown for which covariance values were calculated between μ and each gene’s mRNA and protein concentrations, respectively.
Electronic Supplementary Material (ESI) for Molecular BioSystemsThis journal is © The Royal Society of Chemistry 2013
