Upload
others
View
1
Download
0
Embed Size (px)
Citation preview
This Month in JnmDEPART-MENTS
18F-FDOPA and neuroendocrine tumors:Minn and colleagues provide an overview ofthe use of this tracer in PET and PET/CTimaging of neuroendocrine tumors, pancre-atic b-cell hyperplasia, and other disordersand discuss future applications in diagnosisand therapy. . . . . . . . . . . . . . . . Page 1915
Improving lung scintigraphy: Parker pre-views 2 articles on lung scintigraphy in thisissue of JNM and reviews the current statusof the procedure in the diagnosis of acutepulmonary embolism. . . . . . . Page 1919
Nonrigid registration of chest PET/CT:Grgic and colleagues apply intraindividualanalysis to determine whether a nonrigidregistration algorithm can improve fusionquality of 18F-FDG PET and CT thoracicimages and describe optimal breathingprotocols. . . . . . . . . . . . . . . . . . Page 1921
Tracers in pulmonary NET tumors: Kayaniand colleagues compare the performanceof 68Ga-DOTATATE, a novel selective so-matostatin receptor 2 ligand, and 18F-FDGin detection of pulmonary neuroendocrinetumors. . . . . . . . . . . . . . . . . . . . . .Page 1927
Fitted input function to estimate MRglc:Vriens and colleagues report on and validatea mathematic function to describe the arterialplasma time–activity concentration curve forquantification of glucose metabolic rate andtherapy response monitoring with dynamic18F-FDG PET. . . . . . . . . . . . . . . Page 1933
18F-FDG PET in HNSCC follow-up:Krabbe and colleagues assess the role and
timing of serial 18F-FDG PET scans assurveillance for early locoregional recurrence,distant metastases, and second primary tumorsafter treatment for advanced head and necksquamous cell carcinoma. . . . . . .Page 1940
18F-FDG and 62Cu-ATSM in lung cancer:Lohith and colleagues delineate intratumoraluptake and tracer distribution of 62Cu-ATSM,a hypoxic imaging tracer, and 18F-FDG inpatients with lung cancer of pathohistologi-cally different types. . . . . . . . . . . .Page 1948
Cerebral P-gp inhibition by tariquidar:Wagner and colleagues use PET with(R)-11C-verapamil, a permeability gluco-protein (P-gp) substrate, to measure P-gpfunction at the human blood–brain barrierafter administration of tariquidar, a potentP-gp inhibitor. . . . . . . . . . . . Page 1954
11C-MET PET and glioma progression:Ullrich and colleagues investigate thepotential of 11C-MET PET to detect tumor
progression in patients with gliomas andassess changes in tracer uptake andmolecular immunohistochemical markersduring progression. . . . . . . . Page 1962
Ischemia in cerebral amyloid angiopathy:Chung and colleagues use 99mTc-ECD brainperfusion SPECT to characterize cerebralhypoperfusion in patients with cerebralamyloid angiopathy. . . . . . . . . . . Page 1969
Reference tissue models in BBB disruption:Folkersma and colleagues assess and validatea simplified reference tissue model for ana-lyzing dynamic (R)-11C-PK11195 scans intraumatic brain injury, where blood–brainbarrier disruptions are likely. . . . .Page 1975
Endothelial dysfunction in diabetes:Djaberi and colleague explore the diag-nostic challenge presented by diabeticpatients with myocardial perfusion defectsbut no evidence of obstructive epicardialcoronary disease. . . . . . . . . . Page 1980
V/Q SPECT and low-dose CT vs. MDCTin PE: Gutte and colleagues compare thediagnostic abilities of ventilation–perfusion(V/Q) SPECT, V/Q SPECTwith low-dose CT,and pulmonary multidetector CTangiographywith a combined SPECT/MDCT scanner inpulmonary embolism. . . . . . . . . .Page 1987
Cerebral blood flow in diabetes: Kaplarand colleagues look for differences in globalor regional cerebral blood flow resulting
THIS MONTH IN JNM 11A
by on October 12, 2019. For personal use only. jnm.snmjournals.org Downloaded from
from microvascular damage in types 1 and 2diabetes mellitus. . . . . . . . . . . Page 1993
SPECT for pulmonary embolism: Steinand colleagues provide an educational over-view on the current status and accuracy ofSPECT in acute pulmonary embolism anddiscuss its role in the context of increased useof CT angiography. . . . . . . . . . . . Page 1999
Pretargeted RIT of pancreatic cancer:Karacay and colleagues report on a novelpretargeting procedure for therapeutic de-livery of 90Y-labeled PAM4 IgG, a mono-clonal antibody that recognizes a uniqueepitope associated with a mucin in pan-creatic cancer. . . . . . . . . . . . Page 2008
177Lu-AMBA in GRP-R prostate cancer:Maddalena and colleagues evaluate thetumor binding and imaging potential ofthis radiolabeled bombesin derivative inlow gastrin-releasing peptide receptormodels of prostate cancer and determinehow reduced expression affects radiother-apeutic efficacy. . . . . . . . . . . Page 2017
Systemic radionuclide therapy and glio-mas: Samnick and colleagues test thetherapeutic potential of 131I-IPA, a tumor-specific amino acid derivative, combinedwith external-beam photon radiotherapy inglioma-bearing rats. . . . . . . . Page 2025
RIT with 125I-mAbs: Santoro and col-leagues assess the in vivo biologic efficiency
of internalizing and noninternalizing 125I-labeled monoclonal antibodies for the treat-ment of small solid tumors. . . . . Page 2033
18F-labeled phosphoramidate: Lapi andcolleagues report on studies exploring phos-phoramidates as novel small-molecule pros-tate-specific membrane antigen inhibitorsto develop more effective prostate cancerimaging agents with improved specificityand clearance properties. . . . . . . Page 2042
Mutant TK/GFP fusion reporter: Hsiehand colleagues construct a mutant thymidinekinase/green fluorescent protein reportergene with low cytotoxicity and high temporalresolution for real-time optical and PETmonitoring of transcription induction andother biochemical changes. . . . . Page 2049
Imaging VEGF receptors in abscesses:Levashova and colleagues determinewhether labeled forms of single-chainvascular endothelial growth factor (VEGF)can be used to image VEGF receptors in ananimal model of sterile soft-tissue inflam-mation. . . . . . . . . . . . . . . . . Page 2058
PET radioligand for H3 receptors: Plissonand colleagues synthesize and evaluate thepotential utility of 11C-GSK189254, a hista-mine H3 receptor antagonist, for PETimaging of these receptors. . . . . Page 2064
Therapy and 111In-vinorelbine liposomes:Chow and colleagues investigate the thera-peutic effectiveness of specific amounts ofthese PEGylated liposomes by varyingradiation dosage and concentrations ofchemotherapeutic agents in animal tumorgrowth suppression studies. . . . . Page 2073
Radiolabeled divalent gastrin peptide:Sosabowski and colleagues expand onprevious studies of 111In-labeled divalentgastric peptides with potential for radio-nuclide therapy in tumors overexpressinggastrin/cholecystokinin subtype 2 recep-tors. . . . . . . . . . . . . . . . . . . Page 2082
O N T H E C O V E R
Both ventilation–perfusion SPECT and multidetector CT angiographyhave high accuracy in the diagnosis of pulmonary embolism, butonly limited data comparing the two are available. A prospectivestudy using a hybrid scanner has concluded that ventilation–perfusionSPECT in combination with unenhanced low-dose CT has excellentdiagnostic performance and should probably be considered first-lineimaging in the work-up of most cases of pulmonary embolism.
See page 1990.
12A THE JOURNAL OF NUCLEAR MEDICINE • Vol. 50 • No. 12 • December 2009
by on October 12, 2019. For personal use only. jnm.snmjournals.org Downloaded from
2009;50:11A-12A.J Nucl Med. This Month in JNM
http://jnm.snmjournals.org/content/50/12/11AThis article and updated information are available at:
http://jnm.snmjournals.org/site/subscriptions/online.xhtml
Information about subscriptions to JNM can be found at:
http://jnm.snmjournals.org/site/misc/permission.xhtmlInformation about reproducing figures, tables, or other portions of this article can be found online at:
(Print ISSN: 0161-5505, Online ISSN: 2159-662X)1850 Samuel Morse Drive, Reston, VA 20190.SNMMI | Society of Nuclear Medicine and Molecular Imaging
is published monthly.The Journal of Nuclear Medicine
© Copyright 2009 SNMMI; all rights reserved.
by on October 12, 2019. For personal use only. jnm.snmjournals.org Downloaded from