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Time Is Myocardium and the Wavefront of Necrosis. CM Gibson 2002. The DANAMI-2 Trial. Danish Trial in Acute Myocardial Infarction-2 Presented at the American College of Cardiology 51st Annual Scientific Session Atlanta, GA Dr. Henning Rud Andersen for the DANAMI-2 investigators. - PowerPoint PPT Presentation
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The DANAMI-2 TrialThe DANAMI-2 TrialThe DANAMI-2 TrialThe DANAMI-2 Trial
Danish Trial in Acute Myocardial Infarction-2
Presented at the American College of Cardiology 51st Annual Scientific Session
Atlanta, GA
Dr. Henning Rud Andersenfor the DANAMI-2 investigators
Danish Trial in Acute Myocardial Infarction-2
Presented at the American College of Cardiology 51st Annual Scientific Session
Atlanta, GA
Dr. Henning Rud Andersenfor the DANAMI-2 investigators
High-risk ST elevation MI patients (>4 mm elevation), Sx < 12 hrs5 PCI centers (n=443) and 22 referring hospitals (n=1,129), transfer in < 3 hrs
High-risk ST elevation MI patients (>4 mm elevation), Sx < 12 hrs5 PCI centers (n=443) and 22 referring hospitals (n=1,129), transfer in < 3 hrs
Lytic therapy
Front-loaded tPA 100 mg
(n=782)
Lytic therapy
Front-loaded tPA 100 mg
(n=782)
Death / MI / Stroke at 30 DaysDeath / MI / Stroke at 30 Days
DANAMI-2: Study DesignDANAMI-2: Study DesignDANAMI-2: Study DesignDANAMI-2: Study Design
Primary PCI
with transfer
(n=567)
Primary PCI
with transfer
(n=567)
Primary PCI
without transfer
(n=223)
Primary PCI
without transfer
(n=223)
Stopped early by safety and efficacy committeeStopped early by safety and efficacy committee
DANAMI-2: CentersDANAMI-2: CentersDANAMI-2: CentersDANAMI-2: Centers
14%
8%
0%
4%
8%
12%
16%14%
8%
0%
4%
8%
12%
16%
Dea
th /
MI /
Str
oke
(%
)D
eath
/ M
I / S
tro
ke (
%)
LyticLytic Primary PCIPrimary PCI
P=0.0003P=0.0003 P=0.002P=0.002
CombinedCombined Transfer SitesTransfer SitesP=0.048P=0.048
Non-Transfer SitesNon-Transfer Sites
DANAMI-2: Primary ResultsDANAMI-2: Primary ResultsDANAMI-2: Primary ResultsDANAMI-2: Primary Results
RRR 45%RRR 45%
LyticLytic Primary PCIPrimary PCI LyticLytic Primary PCIPrimary PCI
14%
9%
0%
4%
8%
12%
16%14%
9%
0%
4%
8%
12%
16%
12%
7%
0%
4%
8%
12%
16%
12%
7%
0%
4%
8%
12%
16%
RRR 40%RRR 40%
RRR 45%RRR 45%
2.0%
1.1%
0%
2%
4%
6%
8%
2.0%
1.1%
0%
2%
4%
6%
8%
6.3%
1.6%
0%
2%
4%
6%
8%
6.3%
1.6%
0%
2%
4%
6%
8%7.6%
6.6%
0%
2%
4%
6%
8% 7.6%
6.6%
0%
2%
4%
6%
8%
LyticLytic Primary PCIPrimary PCI
P=0.35P=0.35
DeathDeath
DANAMI-2: ResultsDANAMI-2: ResultsDANAMI-2: ResultsDANAMI-2: Results
LyticLytic Primary PCIPrimary PCI
P=0.15P=0.15
StrokeStroke
LyticLytic Primary PCIPrimary PCI
P<0.0001P<0.0001Recurrent MIRecurrent MI