TIRED OF BEING TIRED?R E C L A I M Y O U R E N E R G Y

W I T H F L O R A D I X

IRON DEFICIENCY PREVALENCE• The most common nutritional deficiency worldwide

• 12-64% are low in iron depending on population studied

• Anemia in pregnant women in North America specifically: 17-31%

• Anemia in US population as a whole: 5.6%

• Iron deficiency in Canadian population as a whole: 3%

• High risk groups: pregnant women, the elderly, women of reproductive age, African-Americans and Hispanics

• For example: prevalence of anemia in African-American women aged 80–85 years is 35.6%, 6.4 times higher than the US population average

• 6.5-19.4% of US seniors are anemic

• 9-13% of Canadian women of reproductive years have depleted iron stores

• Iron deficiency in toddlers aged 12–35 months varies from 6.6%-15.2%

SYMPTOMS OF IRON DEFICIENCY• Too exhausted to get off the couch

• Living in a “brain fog”

• Poor immune health - frequent cold & flu

• Difficulty concentrating and completing tasks

• Too exhausted to exercise

• Simple exercise like flights of stairs lead to dizziness, shortness of breath and racing heart

• Poor circulation with cold hands/feet

• Pale complexion and dark circles under your eyes

• Hair has lost its luster and started to fall out

THE ROLE OF IRON• Cellular energy

• Oxygen transport (hemoglobin)

• Detoxification enzymes

• Thyroid function

• Heart function

• Red blood cell formation

• Growth, fertility, healing and immune health

IRON COMPOUNDS• Elemental iron vs. Iron compounds

• 10 mg of elemental iron per 10 mL dose

• Coming from 87 mg of ferrous gluconate

• Iron + gluconic acid

• Weak & organic vs. strong & inorganic acids

• Solubility

• Vs. ferrous sulphate (65 mg of elemental iron in 325 mg tablets)

• Ferric Fe(III) (oxidized form) vs. Ferrous Fe(II) (reduced form)

• Heme vs. Non-heme

IRON SUPPLEMENTATION ISSUES• Iron overload

• Increased complications in pregnancy

• Poor compliance due to side affects such as digestive upset and constipation

• Iron needs to be in balance/the case for low-dose for prevention

• Iron absorption problems:

• Low stomach acid (seniors, PPI medications, H. pylori infections)

• Celiac disease, Crohn’s disease, intestinal inflammation

• Surgical operations (gastric bypass)

Excess iron ISSUESBoth high and low iron intakes are associated with health issues.Excess iron supplementation (chronic use greater than 60 mg/day) is linked with:

• Complications during pregnancy (diabetes, low birth weights, pre-term birth)

• Constipation/stomach upset• Diabetes• Neurodegenerative diseases (Alzheimer’s, Parkinson’s, etc.)• Iron can produce ROS (reactive oxygen species) causing free radical

damage/inflammation

Non-heme iron and absorption• Requires a carrier (transferrin) to take it from the small intestine to the blood

• If iron stores and hemoglobin are normal, there is feedback to the carrier to shut off absorption

• If iron deficient -> 20% absorption of non-heme iron

• If iron intake is adequate, absorption decreases to 2-3%

• Absorption rates can vary widely based on individual variables

• Most studies do not test absorption but rather changes in iron test values (e.g. hemoglobin, serum ferritin)

Iron & pregnancy• Placenta development

• Increased red blood cell production

• Brain development of the baby

• Iron stores for the baby’s first six months of life

Iron deficiency & pregnancy• Low birth weights

• Pre-term labor

• Postpartum depression

• Poor placenta development

• Increased risk of deficiency with each subsequent pregnancy

• Low intake iron in pregnancy associated with cognitive delays up to age 2

• Miscarriage

Iron & athletes• Athletes have increased iron demand, increased

iron loss and sometimes impaired iron absorption

• Iron increases oxygen uptake, reduces heart rate and decreases lactate concentrations during exercise

• Iron deficiency decreases athletic performance and impairs immune function

• Fatigue, shortness of breath, difficulty concentrating and poor circulation

• Studies: up to 35% of female athletes iron deficient, 3-40% of males

• Why? GI micro-bleeds, foot-strike hemolysis and hepcidin bursts

Tips for best use• Adults take 10 mL on an empty stomach 30 minutes

before meals

• Avoid other mineral supplements (calcium, magnesium, etc.), coffee, tea, red wine, vitamins, herbs, medications in the same 2-hour period

• Box has security seal, measuring cup inside, child-proof cap

• Teeth staining caution

• Refrigerate after opening, use within 4 weeks

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Advantages of salus liquid tonics• Do not require breakdown in the digestive tract so

active ingredients are ready for absorption

• Absorption is enhanced due to larger surface area to volume ratio

• Easy to take for children, elderly and those with digestive problems

• Water-soluble nutrients only

• Herbal and food base enhances the digestibility of ingredients

• Made with organically grown and ethically wild crafted ingredients whenever possible

• Vegetarian friendly

Advantages of salus liquid tonics

• Free of preservatives, additives, artificial color, genetically modified ingredients, pesticide residues, radiation and heavy metals

• Recyclable amber glass bottles

• Great tasting

• Certified Kosher

• European pharmaceutical standards (GMP)

Floradix® liquid iron

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2002 floradix® study• Women between ages 18-65 who were iron deficient but not anemic

• Floradix was found to be effective at returning iron stores to normal over a 16-week period

• Treatment group: 10 mL of Floradix® liquid three times/day (30mg elemental iron total)

• 70% of participants reported feeling “good” or “very good” in terms of improvement of symptoms versus 28% in the control group

• 90% were able to take it without side effects, including constipation

• Median ferritin values rose from 13.0 to 20.0 ug/L in Floradix® treated subjects, with no change in the control group

Examination of the Effective of Floradix (liquid) in women with low ferritin levels-a prospective, random, open intervention study. Department of Gynecology, Endocrinology and Fertility Disorders, Heidelberg Women’s University Clinic, 2002.

2002 floradix® study Examination of the Effective of Floradix (liquid) in women with low ferritin levels-a prospective, random, open intervention study. Department of Gynecology, Endocrinology and Fertility Disorders, Heidelberg Women’s University Clinic, 2002.

Other ferrous gluconate studies• Double blind placebo-controlled study of 90 anemic octogenarians for

60 days

• 15 or 50 mg of liquid ferrous gluconate plus placebo group

• Both iron groups had significant increases in hemoglobin and ferritin concentrations without common adverse reactions of high doses of iron supplementation (abdominal discomfort, nausea, vomiting, changes in bowel movements, constipation and black stools)

Rimon, E., et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. The American Journal of Medicine (2005) 118, 1142-1147.

Other ferrous gluconate studies• 40 pregnant women with iron deficiency anemia in a 1-month study

• Liquid ferrous gluconate was the best absorbed and best tolerated form of iron

• 4 treatment groups of 10 women each and included liquid ferrous gluconate (75 mg per day), solid ferrous gluconate (80 mg per day), solid ferrous sulphate (105 mg per day), and ferric protein succinylate (80 mg per day)

• Ferrous gluconate group, despite using a lower dose than the other groups resulted in a 24% increase in ferritin levels, a 33% increase in red blood cells and a 61% increase in hemoglobin levels. The only group without side effects/dropouts.

Casparis, D., et al. Effectiveness and tolerability of oral liquid ferrous gluconate in iron-deficiency anemia in pregnancy and in the immediate post-partum period: comparison with other liquid or solid formulations containing bivalent or trivalent iron. Minerva Ginecol. 1996 Nov;48(11):511-8.

Floradix® liquid iron

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• On the market for 75+ years

• Made in Germany by Salus®

• Naturopath and midwife recommended

• Packaged in recyclable glass bottles

• Formulated with 10 mg of elemental iron from 87 mg of ferrous gluconate

• Contains vitamins B1, B2, B6, and B12

• In a base of fruit juices, herbs and vegetables

Floradix® liquid iron

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• Designed for prevention and mild deficiencies

• Non-constipating

• Herbs rich in iron (spinach, nettles, kelp)

• Rosehips/vitamin C, B12 and fruit juices to enhance absorption of iron

• Co-factors B12 and B6 to make red blood cells

• Plant-based

• Wheat germ and brewer’s yeast (trace vitamins/minerals)

Uses of Floradix®

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• Prevention of iron deficiency

• Mild iron deficiency and anemia

• Heavy periods

• Digestive problems/poor absorption (Crohn’s, ulcerative colitis, gastric bypass)

• Support for athletic performance particularly endurance athletes and contact sports

Directions and dosages

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• > age 14: Take 10 mL twice daily before meals.

• Children (age 10 – 14): Take 10 mL once daily before a meal.

• Children (age 5 – 9): Take 5 mL once daily before a meal.

• Children (age 2 – 4): Take 4 mL once daily before a meal.

• RDIs

• Women in reproductive years: 18 mg/day

• Men: 8 mg/day

• Pregnancy: 27 mg/day

• Anemia: 30-60 mg/day as directed by health care provider based on bloodwork

Floravit(al) and Floradix® tablets

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Floravit/Floravital• Free of: gluten/wheat germ, brewer’s yeast, honey, kelp

• Same iron and B vitamins as Floradix• Pregnancy and nursing claims in Canada• Vegan

Floradix Iron Tablets• Convenient for travel, cost effective (80/120 size)• Same iron and B vitamins – with folic acid and vitamin C• Light-weight blister pack, child-proof packaging• Talc tested for heavy-metals and asbestos

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Thank youANY QUESTIONS?

Please direct questions, comments and feedback to: info@florahealth.com

Please contact our Customer Service department when you’d like to add your complementary gift to your order:

Canada: customerservice.ca@florahealth.comUSA: customerservice.us@florahealth.com