Tomris Cesuroglu, MDInstitute for Public Health Genomics

PAOG nascholing JeugdgezondheidszorgMaastricht, 25 January 2011

http://childhealthresearch.eu

Research into Child Health

in EuropeRICHE

http://childhealthresearch.eu

http://childhealthresearch.eu

RICHE

An EU funded project (FP7, Mar 2010 to Feb 2013)A project for child health researchers, practitioners,

policy makers, and those who make decisions affecting children

Defining the current pattern of child health research in Europe, seeing what's not being done, and identifying paths to the future of the research

Future proofing child health research policy in EuropeMeeting the future needs of European policy makers,

funders, and children.

http://childhealthresearch.eu

Home Page

http://childhealthresearch.eu

An example

http://childhealthresearch.eu

What's to be done?

Join us!Put up your own workPut up your colleaguesPut up your projectsPut up your reportPut up your funders

Perspectives in Personalized Health Care

Tomris Cesuroglu, MDInstitute for Public Health Genomics

PAOG nascholing JeugdgezondheidszorgMaastricht, 25 January 2011

Life style

External factors

Genetic structure

_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _

Genetic diseases External factors Complex diseases

1% of burden of disease

22% of burden of disease

77% of burden of disease

Disease threshold

*Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research

An Example to a Single Nucleotide Polymorphism

(SNP)

TAT TCG TAC GGC TAC ATA CGT ACC GTA AAT TCG ATT CGA TGAATA AGC ATG CCG ATG TAT GCA TGG CAT TTA AGC TAA GCT ACT

Stop Codon

Start Codon

┐└

┐└

An Example to a Single Nucleotide Polymorphism

(SNP)

TAT TCG TAC GGC TAC ATA CGT GCC GTA AAT TCG ATT CGA TGAATA AGC ATG CCG ATG TAT GCA CGG CAT TTA AGC TAA GCT ACT

Stop Codon

Start Codon

┐└

┐└

Genetic Polymorphism

Dark skin Fair skin

Which one is better?

Gene and Environment/Life Style Interaction

*Slide series used with the courtesy of GENAR Institute for Public Health and Genomics Research

Fair skin Dark skin

Norway

Happily living in Fjords

NigeriaHappily living under African sun

Genetic variation: Is it good or bad?

Fair skin Dark skin

Norway

Nigeria

Genetic variation: Is it good or bad?

Fair skin Dark skin

Norway

Nigeria

•Gets red•Burns•Melanoma

develops

Genetic variation: Is it good or bad?

Fair skin Dark skin

Norway

•Not enough sunshine•Vitamin D

deficiency•Develops

osteoporosis

Nigeria

•Gets red•Burns•Melanoma

develops

Genetic variation: Is it good or bad?

Fair skin Dark skin

Norway

•Not enough sunshine•Vitamin D

deficiency•Develops

osteoporosis

NigeriaPositive intervention:Protecion from the sun

Genetic variation: Is it good or bad?

Fair skin Dark skin

Norway

Positive intervention:Vitamin D supplements

NigeriaPositive intervention:Protecion from the sun

Genetic variation: Is it good or bad?

GSTP 1

Effective detoxification

GSTP 1 (A313G Homozygous)

Ineffective detoxification

Transcription (mRNA production)

Translation in ribosom (synthesis of amino acid chain)

Protein

Transcription (mRNA production)

Translation in ribosom (synthesis of amino acid chain)

Protein

Eric Assamoa

Pathology DevelopmentPhase I

DiseasePhase III

Check-Up Early

Diagnosis

Disease Threshold

Early Symptoms Threshold

Diagnosis and

Treatment

Genetic Predisposition

Life Style and Environmental Conditions

Co

nc

ep

tio

n

De

ath

Early Symp.

Phase II

*Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research

Thank you for your attention!

Tomris Cesuroglu, MD t.cesuroglu@maastrichtuniversity.nl