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Tools for ADME/Toxreagents, standards and model systems
All care has been taken in the compilation of the information contained in thiscatalogue. However, any applications for products are suggestions only, and LGCStandards makes no express or implied representations or warranties regardingthe accuracy, content, completeness, or reliability of the information or anysuggestions provided, and specifically disclaims any and all implied warrantieswith respect to the same, including without limitation any warranties ofmerchantability, fitness or suitability for particular purpose.
� Metabolite standards� Labelled
� Unlabelled
� Enzyme inducers
� Enzyme and transporter,substrates and inhibitors
� Model systems
Example
Example
How to use this reference guide
The new Tools for ADME/Tox guide has been
assembled to make the often time consuming
task of finding the right standards, reagents and
model systems for your research easier than
ever before.
The general product listing on page 26 is
supported by a range of application based index
tables focusing on different pathways including:
• Cytochrome P450 isoenzymes
• Phase II metabolising enzymes
• Transporters.
Each index has been produced detailing the
metabolising enzyme with the relevant substrate,
metabolite, inhibitor or inducer. For easy
reference, substrates and metabolites for any
single metabolism enzyme have been aligned
on opposing pages of the index section.
Index listings
Each metabolism enzyme has relevant
substrates, metabolites, inducers and inhibitors
relevant to the enzyme listed with reference to
FDA Drug Development and Drug interactions:
Table of Substrates, Inhibitors and Inducers
(Appendix I).
1 Metabolising enzyme name
2 Generic substrate/metabolite/inducer/
inhibitor name
3 Reference to FDA preferred (P) and
acceptable (A) compounds as found
in the Drug Development and Drug
Interactions: Table of Substrates,
Inhibitors and Inducers. www.fda.gov
(Appendix I)
4,5,6 Tick refers to presence in the catalogue
listing as either an unlabelled, labelled or
fluorescent compound. All compounds
appear in the catalogue listing.
Compound catalogue listing
The catalogue listing includes all products
indicated by a tick in the index tables. In addition
there are specific quick reference guides for
labelled and fluorescent products (pages 41
and 43) following the general catalogue listing.
1 Generic compound name as found in
the index
2 LGC Standards catalogue number
3 Actual product description
4 Pack size available.
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-A168125TRC-A168125-100TRC-A192400TRC-A192400-2.5TRC-A192402TRC-A192402-10TRC-A247500
Product description
5-Acetylamino-6-amino-3-methyluracil, Hydrate5-Acetylamino-6-amino-3-methyluracil, HydrateAcyclovirAcyclovirAcyclovir-d4Acyclovir-d4Adefovir
Pack size
10 mg100 mg250 mg2.5 g1 mg10 mg10 mg
Index description
AAMU (5-acetylamino-6-amino-3-methyluracil)AAMU (5-acetylamino-6-amino-3-methyluracil)AcyclovirAcyclovirAcyclovirAcyclovirAdefovir
42 31
Substrates: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
CYP450metabolismenzymes
CYP1A1
CYP1A2
CYP1A2
CYP1A2
CYP1A2
Substrate
7-ethoxyresorufin
7-ethoxyresorufin
R-warfarin
Phenacetin
Tacrine
�
�
�
�
Unlabelled
FDA
A
P
A
Labelled
�
�
Fluorescent
1 2 4 5 63
FRANCE
Molsheim
Borås
LuckenwaldeWesel
SWEDEN
GERMANY
LomiankiPOLAND
Brno
CZECH REPUBLIC
Turku
FINLAND
Cluj-Napoca
ROMANIA
BULGARIASofia
SzentendreHUNGARY
MilanITALY
SPAINBarcelona
Beijing
CHINA
TURKEY
Istanbul
INDIAMumbai
Bangalore
Hyderabad
Magherafelt
Bury
Teddington
N. IRELAND
UKIRELAND
St Petersburg Russia
Rhode IslandUSA
dards l
About LGC Standards
LGC Standards is recognised by laboratory
scientists throughout the world as a leading
supplier of analytical standards, products and
services to support laboratory quality. The LGC
Standards product portfolio includes:
• Comprehensive source of reference materials
for a wide range of analyses including food,
environmental, pharmaceutical, clinical
and industrial;
• Production of pharmaceutical impurities
and custom synthesis;
• Proficiency testing schemes;
• Analytical quality training courses;
• Biological standards and controls.
Partnerships
Our partnerships with many of the world’s
leading standards and reference materials
producers combined with our own production
capabilities have positioned LGC Standards as
an integral supplier to both research and quality
control laboratories across a diverse range of
industries. Our partnership with ATCC® has
helped to facilitate the supply of biological
cultures and bioproducts to the European life
science research community for almost 10 years.
The new Tools for ADME/Tox guide provides
a uniquely formatted range of products that
have been developed to aid drug discovery
and development researchers find the right
standards, reagents and model systems to
support their research.
Our team of technical support and regulatory
specialists are on hand to provide expert advice
on sourcing the right materials for your research
and assistance with regulatory requirements
associated with controlled substances.
LGC Standards - global quality management solutions for the laboratory.
www.lgcstandards.com
Genuine ATCC culturesand bioproducts for theEuropean pharmaceuticalcommunity
LGC Standards is the exclusive distributor of ATCC®
cultures and bioproducts in Europe. We are committedto providing authentic, high-quality ATCC cultures tosupport quality control and research activities acrossthe pharmaceutical industry.
With a local stock of all key quality control strains anda wide selection of other cultures, LGC Standards is ableto offer:
� Faster delivery of ATCC products
� Expert technical support
� Expedited handling of special forms and paperworkto meet import regulations
� Reduced shipping costs
For further information or to receive any one of ourcatalogues, please contact your local office or visitour website.
www.lgcstandards-atcc.org
Primary cells
Cell lines and hybridomas
Cell culture media, seraand reagents
Animal and plant viruses
Genomic DNA
Quality control strains
cDNA clones, vectorsand libraries
Microbial media andsupplements
Cyropreservation products
Contents
Drug stability
ADME/Tox analyses
Drug-Drug interaction studies
CYP inhibition and induction
Evaluating permeability
Isotopically labelled products
Transporters
Model systems
Enzyme and transporter index
Substrates and metabolites
Phase I metabolising enzymes; CYP450
Phase II metabolising enzymes
Inhibitors
Phase I metabolising enzymes; CYP450
Phase II metabolising enzymes
Inducers
Phase I metabolising enzymes
Phase II metabolising enzymes
Transporters: Substrates and inhibitors
Compound catalogue list
Catalogue (labelled, unlabelled and fluorescent)
Quick reference compound lists
Fluorescent products only
Labelled products only
ATCC® microbiology cultures
ATCC® cell biology cultures
Primary cells, media and reagents
Fresh hepatocytes from LGC Standards
Ultra pure solvents
Introduction
Reagents / sorbents
Ion pair reagents
LC-MS additives
High purity solvents and acids
Appendix I
Appendix II
6
6
7
7
7
8
9
10
11
12
16
20
21
22
23
24
27
41
43
50
51
54
55
56
57
58
58
59
60
78
79
6 www.lgcstandards.com
ADME/Tox analyses
As ADME/Tox analyses become more advanced
and reliable in terms of accuracy and prediction,
an increase in their usage is expected during the
initial development and screening phase of
innovative drug development. The approval of
new drugs commonly takes between seven and
ten years and has been estimated to cost
between $700 million and $900 million. Estimates
that up to 90 per cent of the clinical candidates
are likely to fail due to pharmacokinetics,
ADME-related problems, lack of efficacy and
side effects make new compound development
a high risk business for drug companies. As a
result, researchers are realising the importance
of screening potential hit compounds for
significant ADME and toxicity profiles earlier
in their development.
Drug stability
The way in which a compound is metabolised or
accumulated in the body is a key determinant of
bioavailability. A drug that is rapidly metabolised
may require multiple daily dosing or continuous
infusion to maintain a concentration in the
bloodstream or target organ that is sufficient to
elicit a therapeutic effect. However, a slowly
metabolised drug may remain in the body for
long periods, causing toxic build-up.
For evaluating oxidative or conjugation
metabolism, a variety of model systems are
available including:
• Liver microsomes
• Liver S9
• Hepatocytes
• Intestinal microsomes
• Intestinal S9
• Individual CYP isoforms for CYP phenotyping
(phase 1 metabolism)
• Individual UGT isoforms for assessing
phase 2 metabolism.
The use of hepatocytes may provide a model
more representative of the in vivo situation
because they contain a cell membrane and
do not require additional co-factors (as with
microsomes). Hepatocytes contain enzymes
for both phase I (oxidation, reduction and/or
hydrolysis of test compound) and phase II
(conjugation of test compounds or metabolites)
metabolism.
7www.lgcstandards.com
Drug-Drug interaction studies
Metabolism-based drug-drug interactions occur
when a drug inhibits or induces the activity of a
drug metabolising enzyme, which catalyzes the
metabolism of the concomitant drug.
Metabolism-based drug-drug interaction is one
of the major factors that cause drug failures
during development. Early stage screening of
compounds for potential drug-drug interactions
using in vitro techniques becomes necessary in
order to decrease late stage compound attrition.
DMPK laboratories provide a wide variety of
valuable metabolism-based drug-drug interaction
screening assays, such as cytochrome P450
(CYP) inhibition assays and CYP induction
assays.
CYP Inhibition assays
Fluorescent dyes: The probe substrates used
in these assays are derivatives of coumarin or
resorufin, which after dealkylation by CYPs will
generate fluorescent products. Because these
substrates are generally not highly specific to
the individual CYP isozyme confirmation studies
are required to identify specific inhibition effects.
The more detailed and confirmative investigation
of CYP inhibition should use traditional probe
substrates, which are more specific to individual
CYP isoforms. For instance, midazolam
1-hydroxylation and testosterone 6β-hydroxylationare pathways catalysed predominantly by
CYP2D6. Because these substrates are more
specific to individual CYP isoforms, the inhibition
assays can be performed with not only the
individual recombinant CYP isoform but also the
liver microsomes or other tissue preparations,
such as hepatocytes, which contain all CYP
enzymes (see page 12).
CYP Induction
Some chemicals can induce the activity of CYP
enzymes. The chemical inducers will increase
the metabolism of concomitant drugs that are
the substrates of the induced CYP enzymes,
resulting in concomitant drugs losing efficacy.
CYP enzymes such as CYP1A2, CYP2B6,
and CYP3A4 are susceptible to induction (see
page 22).
The induction assays are typically performed
using plateable human or rat hepatocytes
(see page 55).
Evaluating permeability
Drug permeability through cell monolayer has
been shown to correlate well with intestinal
permeability and oral bioavailability. Drugs with
low membrane permeability, i.e. low lipophilicity,
are generally absorbed slowly from solution in
the stomach and small intestine. Knowing the
rate and extent of absorption across the intestinal
tract is critical if a drug is to be orally delivered.
One of the most important systems for in vitro
human experimentation is the Caco-2 cell
system for monitoring intestinal absorption
and secretion of drugs (see page 53).
Caco-2 / TC7 (ATCC® CRL-2102TM and HTB-37TM)
Mandin-Darby canine kidney (MDCK) cells are
used as a model for studying drug transport in
distal renal epithelia (see page 51).
MDCKII, MDCK (ATCC® CCL-34TM)
MDR1-MDCKII
8 www.lgcstandards.com
Isotopically labelled products
Due to its high selectivity and sensitivity liquid
chromatography-mass spectrometry (LC-MS)
with quadrupole mass analysers are replacing
traditional UV detection in many bioanalytical
laboratories. ESI, APCI and APPI have become
the ionization techniques of choice, covering a
wide variety of analytes.
The LC-MS methods are usually validated
according to the FDA’s 2001 Guidance:
Bioanalytical Method Validation.
Isotopically labeled (2H or 13C) internal
standards have become very popular because
they are capable of compensating for losses
during sample preparation; LC separation; and
differences in ionisation efficiencies or degree
of ionisation often caused by co-elution of matrix
constituents with the analyte.
The labelled products listing begins on page 43.
9www.lgcstandards.com
Transporters
Current evidence suggests that the role of
transporters in the absorption, distribution, and
excretion of drugs as well as in pharmacology,
toxicology and drug-drug interactions (DDIs)
may be significant. Currently, regulatory
agencies are focusing on these potential
transporter-mediated DDIs.
The molecular and functional characterisation
of transport proteins is emerging rapidly and
significant numbers of drugs have been shown
to be substrates or inhibitors.
Two major groups of proteins are involved in
drug transport. The first includes multispecific
solute carrier (SLC) transporters, facilitating
the cellular entry or exit of a wide range of
compounds. In the liver, transport proteins are
present on the sinusoidal membrane that can
be the rate-limiting step in hepatic clearance for
some drugs. Mechanistic studies clearly suggest
a key role and broad substrate specificity for the
SLC family.
The second major group of transporters are the
multidrug resistance (MDR) ATP binding
cassette (ABC) proteins. They play an important
role in cancer drug resistance, protection against
xenobiotics, and in the passage of drugs through
cellular and tissue barriers. For absorption, a
clear role has emerged for P-glycoprotein (Pgp)
in limiting permeability across the gastrointestinal
tract. Pgp and MRP2 govern also active biliary
excretion. Similarly, at the blood-brain barrier
a range of drugs has limited brain penetration
due to Pgb-mediated efflux, which can limit
therapeutic effectiveness of CNS agents.
In drug discovery, key challenges are to choose
the most appropriate and convenient assay, and
to implement and validate the results. According
to the current guidelines of the FDA, such
investigations should be performed in the early
stage of drug development, using ‘suitable in vitro
probes’. For predicting in vivo drug–transporter
interactions, the FDA recommends cell-based
transport assays, such as Caco-2 and
Pgp-transfected forms of the MDCK or LLC-PK1
cells (see page 51).
10 www.lgcstandards.com
Model systems
There are a variety of cell types and other model
systems used across many different applications
in pre-clinical research. These models, many
of which are described on page 6 are used to
develop an insight into the efficacy and potential
of new drug candidates including applications
in pharmacology, toxicology and other assay
or study types. ATCC® cells which may be
appropriate as model systems can be found
on pages 51 - 54.
Fresh hepatocytes
LGC Standards can supply fresh hepatocytes
from a variety of species. The use of fresh
hepatocytes offers a number of advantages
over other model systems particularly in
experiments designed to investigate enzyme
induction, membrane transport and phase II
metabolism. Each batch of cells can be provided
with a certificate of analysis and despatched
guaranteeing delivery the following day.
Fresh hepatocytes from LGC Standards
(page 55)
• Plateable single source hepatocyte
preparations
• Availability from a variety of species
• Full enzyme profile maintained allowing
assessment of phase II metabolism
• Transport mechanisms and functional
integrity maintained allowing increasingly
important transport mechanisms to be
investigated
• Cells available in suspension or multi-well
plated format.
Hepatocytes are available in a range of formats.
Discounts are available for large volume users.
Contact your local LGC Standards office for
further information including isolation schedules
.
ATCC® Primary Cell Solutions™ (page 54)
Primary cell cultures more closely mimic the
physiological state of cells in vivo and generate
more relevant data representing living systems.
ATCC® Primary Cell Solutions™ are designed
to provide all of the components needed to
assemble a complete culture system for specific
cell types. Backed by the same quality, service,
and support that you have come to expect from
ATCC, the product offering is comprised of:
• Cryopreserved primary cells of the highest
quality from a trusted source;
• Optimised media and growth factor kits to
support growth in serum-free or low serum
conditions; and,
• Reagents that have been fine-tuned for
reliable use with primary cells.
Enzyme and transporterindex
� Metabolite standards
� Substrates
� Inhibitors
� Inducers
12 www.lgcstandards.com
Substrates: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
CYP450metabolismenzymes
CYP1A1
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1B1
CYP2A1
CYP2A6
CYP2A6
CYP2A6
CYP2B1
CYP2B6
CYP2B6
CYP2B6
CYP2B6
CYP2C8
CYP2C8
CYP2C8
CYP2C8
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C11
CYP2C11
CYP2C19
CYP2C19
CYP2C19
Substrate
7-ethoxyresorufin
7-ethoxyresorufin
R-warfarin
Phenacetin
Tacrine
Theophylline
Caffeine
R-warfarin
7-benzyloxyresorufin
Testosterone
Coumarin
Nicotine
Nicotine
Testosterone
S-mephenytoin
Bupropion
Propofol
Efavirenz
Taxol
Amodiaquine
Paclitaxel
Rosiglitazone
Naproxen
Tolbutamide
Diclofenac
R-warfarin
S-warfarin
Tolbutamide
Flurbiprofen
Phenytoin
Testosterone
Testosterone
S-mephenytoin
Omeprazole
Fluoxetine
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FDA
A
P
A
A
A
P
P
A
P
A
P
P
A
A
P
P
P
A
A
P
A
A
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Fluorescent
FDA Drug development and drug interaction guidance tables (Appendix I)P = Preferred substrate A = Acceptable substrate
Please note: Greyed substrates were not available at date of printing. Please contact your local LGC Standards for current availability.
13www.lgcstandards.com
Metabolites: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
CYP450metabolismenzymes
CYP1A1
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP1B1
CYP2A1
CYP2A6
CYP2A6
CYP2A6
CYP2B1
CYP2B6
CYP2B6
CYP2B6
CYP2B6
CYP2C8
CYP2C8
CYP2C8
CYP2C8
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C11
CYP2C11
CYP2C19
CYP2C19
CYP2C19
Metabolite
Resorufin
Resorufin
6-hydroxywarfarin
Paracetamol (Acetaminophen)
1-methylxanthine
Paraxanthine
8-hydroxywarfarin
Resorufin
6α-hydroxytestosterone (rat metabolite)7-hydroxycoumarin
Cotinine
3-hydroxycotinine (secondary)
S-(+)-N-desmethylmephenytoin (S-Nirvanol)
Hydroxybupropion
4-hydroxypropofol
8-hydroxyefavirenz
Desethylamodiaquine
6α-hydroxypaclitaxel5-hydroxyrosiglitazone
O-desmethylnaproxen
Carboxytolbutamide
4'-hydroxydiclofenac
6-hydroxywarfarin
7-hydroxywarfarin
4-hydroxytolbutamide
4'-hydroxyflurbiprofen
4-hydroxymephenytoin
5-hydroxyomeprazole
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14 www.lgcstandards.com
CYP450metabolismenzymes
CYP2D6
CYP2D6
CYP2D6
CYP2D6
CYP2D6
CYP2E1
CYP2E1
CYP2E1
CYP3A2
CYP3A2
CYP3A1&2
CYP3A4/5
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4/5
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4/5
CYP3A4/5
CYP2J2
CYP4F12
Substrate
Metoprolol
Tramadol
Bufuralol
Debrisoquin
Dextromethorphan
Lauric acid
Chlorzoxazone
7-ethoxycoumarin
Testosterone
Testosterone
Felodipine
Terfenadine
Quinidine
Dapsone
Oxybutynin
Cortisol
Terfenadine
Paclitaxel
Testosterone
7-benzyloxyresorufin
R-warfarin
S-warfarin
Midazolam
Dextromethorphan
Midazolam
Terfenadine alcohol metabolite
Nifedipine
Erythromycin
Triazolam
Terfenadine alcohol metabolite
Terfenadine alcohol metabolite
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FDA
P
A
P
A
P
A
P
P
A
A
A
A
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�
Fluorescent
Substrates: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
FDA Drug development and drug interaction guidance tables (Appendix I)P = Preferred substrate A = Acceptable substrate
Please note: Greyed substrates were not available at date of printing. Please contact your local LGC Standards for current availability.
15www.lgcstandards.com
Metabolites: CYP450 metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
CYP450metabolismenzymes
CYP2D6
CYP2D6
CYP2D6
CYP2D6
CYP2D6
CYP2E1
CYP2E1
CYP2E1
CYP3A2
CYP3A2
CYP3A1&2
CYP3A4/5
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4/5
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4/5
CYP3A4/5
CYP2J2
CYP4F12
Metabolite
α-hydroxymetoprololO-desmethyltramadol
1-hydroxybufuralol
(±)-4-hydroxydebrisoquin sulfate
Dextrorphan
6-hydroxychlorzoxazone
7-hydroxycoumarin
Dehydrofelodipine
(3S)-3-hydroxyquinidine
Dapsonehydroxylamine
Desethyloxybutynin
6β-hydroxycortisol
p-3-hydroxypaclitaxel
6β-hydroxytestosteroneResorufin
10-hydroxywarfarin
4-hydroxywarfarin
1'-hydroxymidazolam
4-hydroxymidazolam
Fexofenadine
N-demethylerythromycin
4-hydroxytriazolam
Fexofenadine
Fexofenadine
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Fluorescent
16 www.lgcstandards.com
Substrates: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
Phase IIMetabolismEnzymes
UGTs
UGTs
UGTs
UGTs
UGTs
GSTs
SULTs
SULTs
NATs
UGT Isoform
1A1
1A1
1A1
1A4
1A4
1A4
1A4
1A4
1A6
1A6
1A6
1A8
1A9
1A9
1A10
2B7
2B7
2B7
2B7
Substrate
Morphine
4-hydroxymidazolam
Naproxen
Hydromorphone
7-hydroxycoumarin
Paracetamol (Acetaminophen)
Paracetamol (Acetaminophen)
7-hydroxycoumarin
Dapsone
SN-38 (Irinotecan metabolite)
Estradiol
Etoposide
Imipramine
Olanzapine
Trifluoperazine
Midazolam
Posaconazole
Serotonin
Deferiprone
Diclofenac
Hydroxydesloratadine
Propofol
Sulfinpyrazone
Dopamine
Carbamazepine
21-hydroxyprogesterone
Zidovudine (azidothymidine, AZT)
Morphine
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17www.lgcstandards.com
Metabolites: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
Phase IIMetabolismEnzymes
UGTs
UGTs
UGTs
UGTs
UGTs
GSTs
SULTs
SULTs
NATs
UGT Isoform
1A1
1A1
1A1
1A4
1A4
1A4
1A4
1A4
1A6
1A6
1A6
1A8
1A9
1A9
1A10
2B7
2B7
2B7
2B7
Metabolite
Morphine-3-β-D-glucuronide4-hydroxymidazolam-β-D-glucuronideNaproxen acyl-β-D-glucuronideHydromorphone-3-glucuronide
7-hydroxycoumarin-glucuronide
Paracetamol-glutathione
Paracetamol sulfate
7-hydroxycoumarin sulfate
Monoacetyldapsone
Olanzapine-glucuronide
1'-hydroxymidazolam-β-D-glucuronide
Deferiprone-3-O-β-D-glucuronideDiclofenac acyl-β-D-glucuronide3-hydroxydesloratadine-β-D-glucuronide
Dopamine-3-β-D-glucuronide
Morphine-6-β-D-glucuronide
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Unlabelled
�
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Labelled
�
�
Fluorescent
18 www.lgcstandards.com
Substrates: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
SULT Isoform
2A1
1E1
1E1
1A3
NAT Isoform
Mouse Nat-1
Mouse Nat-2
NAT-1
NAT-1
NAT-2
NAT-2
NAT-2
NAT-2
NAT-2
Substrate
Raloxifene
4-hydroxytamoxifen
Ethynylestradiol
Troglitazone
Isoniazid
p-aminobenzoic acid
p-aminosalicylic acid
p-aminobenzoic acid
Sulfamethazine
Procainamide
Isoniazid
7-aminoclonazepam
AFMU (5-acetylamino-6-formylamino-3-methyluracil)
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Unlabelled
�
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�
Labelled
Fluorescent
19www.lgcstandards.com
Metabolites: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
SULT Isoform
2A1
1E1
1E1
1A3
NAT Isoform
Mouse Nat-1
Mouse Nat-2
NAT-1
NAT-1
NAT-2
NAT-2
NAT-2
NAT-2
NAT-2
Metabolite
Ethynylestradiol-3-sulfate
N-acetyl-4-aminosalicylic acid
N-acetylsulfamethazine
AAMU (5-acetylamino-6-amino-3-methyluracil)
�
�
�
�
Unlabelled
�
Labelled
Fluorescent
20 www.lgcstandards.com
Inhibitors: Phase l metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
Phase Imetabolismenzymes
CYP1A2
CYP1A2
CYP2A6
CYP2A6
CYP2A6
CYP2A6
CYP2B6
CYP2B6
CYP2B6
CYP2B6
CYP2B6
CYP2B6
CYP2C8
CYP2C8
CYP2C8
CYP2C8
CYP2C8
CYP2C9
CYP2C9
CYP2C9
CYP2C9
CYP2C19
CYP2C19
CYP2C19
CYP2C19
CYP2C19
CYP2C19
CYP2C19
CYP2D6
CYP3A4
CYP3A4
CYP3A4
CYP3A4/5
CYP3A4/5
CYP3A4/5
CYP3A4/5
Inhibitor
Fluvoxamine
α-naphthoflavoneMethoxsalen
Pilocarpine
Tranylcypromine
Tryptamine
Ketoconazole
Clopidogrel
Phencyclidine
Sertraline
Ticlopidine
Thiotepa
Gemfibrozil
Quercetin
Montelukast
Pioglitazone
Trimethoprim
Fluvastatin
Fluconazole
Fluoxetine
Fluvoxamine
(+/-)-N-3-benzylnirvanol
(S)-(+)-N-3-benzylnirvanol
(R)-(-)-N-3-benzylnirvanol
Ticlopidine
Tranylcypromine
Nootkatone
Oxybutynin
Quinidine
6',7-dihydroxybergamottin
Erythromycin
Troleandomycin
Ketoconazole
Azamulin
Itraconazole
Verapamil
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FDA
A
P
A
P
A
A
A
A
A
A
A
P
P
A
A
A
A
A
A
A
P
P
A
P
A
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Unlabelled
Labelled
21www.lgcstandards.com
Inhibitors: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
Phase IImetabolismenzymes
UGTs
UGTs
UGTs
UGT 1A1
UGT 1A4
UGT 2B7
SULT 1E1
NAT2
NAT2
Inhibitor
Quercetin
Valproic acid
Probenecid
Atazanavir
Hecogenin
Fluconazole
Tricin
Paracetamol(Acetaminophen)
Retinoic acid
�
�
�
�
�
�
�
�
�
FDA
�
�
�
�
�
�
Unlabelled
Labelled
FDA Drug development and drug interaction guidance tables (Appendix I)
P = Preferred inhibitor
A = Acceptable inhibitor
22 www.lgcstandards.com
Inducers: Phase I metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
Phase Imetabolismenzymes
CYP1A
CYP1A1
CYP1A2
CYP1A2
CYP1A2
CYP1A2
CYP2A6
CYP2B6
CYP2B6
CYP2B6
CYP2C8
CYP2C9
CYP2C9
CYP2C19
CYP3A
CYP3A1
CYP3A2
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4
CYP3A4
Inducer
β-naphthoflavone (RatCYP1A)Omeprazole3-methylcholanthreneLansoprazoleβ-naphthoflavoneOmeprazoleDexamethasonePhenobarbitalPhenytoinRifampicinPhenobarbitalPhenobarbitalRifampicinRifampicinDexamethasone (RatCYP3A)RifampicinRifampicinRifampicinDexamethasonePhenobarbitalPhenytoinRifapentineTroglitazone
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�
FDA
P
A
P
P
P
P
A
P
A
A
P
P
P
A
A
A
A
A
�
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Unlabelled
Labelled
23www.lgcstandards.com
Inducers: Phase II metabolism enzymesThe catalogue tab contains all available compounds. Available unlabelled, labelled and fluorecent compounds are indicated by the ‘�’
Phase IImetabolismenzymes
UGTs
UGTs
UGTs
UGTs
GST
Inducer
Phenobarbital
Phenytoin
Carbamazepine
Efavirenz
Sulforaphane
�
�
�
�
�
FDA
�
�
�
�
Unlabelled
Labelled
FDA Drug development and drug interaction guidance tables (Appendix I)
P = Preferred inducer
A = Acceptable inducer
24 www.lgcstandards.com
Substrates and inhibitors: TransportersThe catalogue tab contains all compounds listed in substrate and inhibitor columns available as labelled and non-labelled products.
Gene
ABCB1
ABCB4
ABCB11
ABCC1
abcc2
ABCC2
ABCC3
ABCC4
ABCC5
ABCC6
ABCG2
slco1a1
SLCO1A2
SLCO1B1
Aliases
P-gp, MDR1,GP170, PGY1,CLCS
MDR2, MDR3, PGY3,GBD1, PFIC-3BSEP, PFIC-2,PGY4, SPGPMRP1, GS-X
ratMrp2MRP2, CMOAT,DJS
MRP3, cMOAT2,MLP2, MOAT-D
MRP4, MOAT-BMRP5, MOAT-C,SMRPMRP6, MLP1, PXE,ARABCRP, MXR, ABCP
ratOatp1a1OATP1A2, OATP-A,OAT-P, SLC21A3OATP1B1, OATP-C,LST-1, SLC21A6
Inhibitor
Cyclosporine A, Elacridar,Ketoconazole, Nelfinavir,Quinidine, Reserpine, Ritonavir,Saquinavir, Tacrolimus,Verapamil
Cyclosporine A
Elacridar (GF120918), Gefitinib,Lapatinib, Erlotinib, Novobiocin,Ritonavir, Chlorothiazide
Ketoconazole
Cyclosporine A, Rifamycin
Substrate
Digoxin, Loperamide,Quinidine, Vinblastine
Digoxin, Paclitaxel, Vinblastine
Vinblastine
Adefovir, Indinavir, Paclitaxel,Flutamide, EtoposideProbenecidIndinavir, Cisplatin,Probenecid, Estradiol,Bilirubin glucuronide,Etoposide, DoxorubicinEtoposide (VP-16),Methotrexate,Benzbromarone, CisplatinMethotrexate, Adefovir6-mercaptopurine,ThioguanineCisplatin, Daunorubicin
Daunorubicin, Doxorubicin,Topotecan, Rosuvastatin,Sulfasalazine, Mitoxantrone,Prazosin, Methotrexate
Rifampicin, Rosuvastatin,Methotrexate, Pravastatin,Thyroxine, Atorvastatin,Pitavastatin, Valsartan,Olmesartan, Enalapril,Temocaprilat, Benzylpenicillin,Cerivastatin
25www.lgcstandards.com
Substrates and inhibitors: TransportersThe catalogue tab contains all compounds listed in substrate and inhibitor columns available as labelled and non-labelled products.
Gene
SLCO1B3
SLCO2B1
SLCO4C1
SLC10A1
SLC15A1
SLC15A2
SLC22A1
SLC22A2
SLC22A3
SLC22A4
SLC22A5
SLC22A6
SLC22A7
SLC22A8
Aliases
OATP1B3, OATP8,SLC21A8
SLC21A9, OATP-B,OATP2B1OATP4C1, OATP-H,OATPX, SLC21A20NTCPPEPT1, HPECT1,HPEPT1PEPT2
OCT-1
OCT-2
OCT-3, EMT
OCTN1,MGC34546OCTN2, SCD,CDSPOAT1, ROAT1,PAHTOAT2, NLTOAT3
Inhibitor
Fluvastatin
Fluvastatin
Cefadroxil
Disopyramide, Midazolam,Phenformin, Phenoxy-benzamine,Quinidine, Quinine, Ritonavir,VerapamilDesipramine, Phenoxy-benzamine,Quinine, VerapamilDesipramine, Prazosin,Phenoxy-benzamine
Probenecid, Cefamandole,Cefazolin, Benzbromarone
Probenecid, Cefadroxil,Cefamandole, Cefazolin
Substrate
Digoxin, Methotrexate,Rifampicin, Rosuvastatin,Pravastatin, Pitavastatin,Fexofenadine, Digoxin,Paclitaxel, Repaglinide,Telmisartan, Valsartan,OuabainPravastatin, Benzylpenicillin
Digoxin, Ouabain
RosuvastatinAmpicillin, Amoxicillin,Captopril, ValacyclovirAmpicillin, Amoxicillin,Captopril, ValacyclovirAcyclovir, Amantadine,Desipramine, Ganciclovir,Metformin
Amantadine, Cimetidine,MemantineCimetidine
Quinidine, Verapamil
Quinidine, Verapamil
Acyclovir, Adefovir,Methotrexate, ZidovudineZidovudineCimetidine, Methotrexate,Zidovudine
High purity solventsfrom LGC Standards
LGC Standards, Europe’s most comprehensive sourceof reference materials, substances, cell cultures andbioproducts, offers a full range of high purity solventsfor use in the laboratory and particularly for analyticaltechniques.
We provide a range of over 80 different solvents includingPicograde® solvents for residue analysis, Optigrade®
solvents for HPLC, special grades for the analysis ofvolatile, halogenated or aromatic organic compoundsas well as our new range of LC-MS solvents andcustomised solvent mixes.
Through our extensive distribution network of Europeanoffices, and our expertise in technical support, LGCStandards is the ideal source for all your solvents:
� Expert local customer service and technical support
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� MSDS and certificate of analysis provided
For further information or to place an order, pleasecontact your local office.
Range of over 80 solvents
Picograde® solvents forresidue analysis
Optigrade® solvents for HPLC
New LC-MS solvents
Customised solvent mixes
Special grades for highlyvolatile halogenated andaromatic hydrocarbonsand EOX
Solvents for high accuracymeasurements
www.lgcstandards.com
Compound catalogue list
Labelled and unlabelled
� Metabolite standards
� Enzyme substrates
� Enzyme inducers
� Enzyme inhibitors
� Transporter inhibitors
� Transporter substrates
28 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-A168125TRC-A168125-100TRC-A192400TRC-A192400-2.5TRC-A192402TRC-A192402-10TRC-A247500TRC-A247500-100TRC-A247502TRC-A247502-25TRC-A168210
TRC-A168210-50
TRC-A168212
TRC-A168212-10
TRC-A168213
TRC-A168213-10
TRC-A575820TRC-A575820-50TRC-A575822TRC-A575822-10CERA-915CERA-916CERA-917
TRC-A603610TRC-A603610-10TRC-A634200TRC-A634200-100TRC-A634202TRC-A634202-10EPA0800000MM0232.00TRC-A634237TRC-A634238TRC-A634238-10EPA1100000MM0253.15TRC-A634302TRC-A790051TRC-A790051-50TRC-A790052TRC-A790052-10TRC-A791750TRC-A791750-500TRC-A791752TRC-A791752-10TRC-A801530TRC-A801530-50EPY0000775MM0456.00TRC-B285770TRC-B285770-100TRC-B285775TRC-B285775-50TRC-B285776TRC-B285776-50EPB0700000MM0160.00TRC-B288600TRC-B288600-100TRC-B385310
Product description
5-Acetylamino-6-amino-3-methyluracil, Hydrate5-Acetylamino-6-amino-3-methyluracil, HydrateAcyclovirAcyclovirAcyclovir-d4Acyclovir-d4AdefovirAdefovirAdefovir-d4Adefovir-d45-Acetylamino-6-formylamino-3-methyluracil
5-Acetylamino-6-formylamino-3-methyluracil
5-Acetyl-d3-amino-6-formylamino-3-methyluracil
5-Acetyl-d3-amino-6-formylamino-3-methyluracil
5-Acetylamino-6-formylamino-3-methyluracil-d3
5-Acetylamino-6-formylamino-3-methyluracil-d3
Amantadine HydrochlorideAmantadine HydrochlorideAmantadine-d15 HydrochlorideAmantadine-d15 Hydrochloride7-Aminoclonazepam, 100 µg/mL, in Acetonitrile7-Aminoclonazepam, 1.0 mg/mL, in Acetonitrile7-Aminoclonazepam-D4, 100 µg/mL, inAcetonitrile7-Amino Clonazepam7-Amino ClonazepamAmodiaquinAmodiaquinAmodiaquin-d10Amodiaquin-d10Amoxicillin trihydrateAmoxicillin TrihydrateAmoxicillin-13C6Amoxicillin-d4Amoxicillin-d4Ampicillin TrihydrateAmpicillin TrihydrateAmpicillin-d5 (Mixture of Diastereomers)AtazanavirAtazanavirAtazanavir-d5Atazanavir-d5Atorvastatin, Calcium SaltAtorvastatin, Calcium SaltAtorvastatin-d5, Sodium SaltAtorvastatin-d5, Sodium SaltAzamulinAzamulinBenzbromaroneBenzbromarone(+/-)-N-3-Benzylnirvanol(+/-)-N-3-Benzylnirvanol(S)-(+)-N-3-Benzylnirvanol(S)-(+)-N-3-Benzylnirvanol(R)-(-)-N-3-Benzylnirvanol(R)-(-)-N-3-BenzylnirvanolBenzylpenicillin potassiumBenzylpenicillin PotassiumBenzylpenicillinate-d7, Potassium SaltBenzylpenicillinate-d7, Potassium SaltBilirubin Acyl-β-D-glucuronide (Mixture ofMonoglucuronides)
Pack size
10 mg100 mg250 mg2.5 g1 mg10 mg10 mg100 mg2.5 mg25 mg5 mg
50 mg
1 mg
10 mg
1 mg
10 mg
5 g50 g1 mg10 mg1 mL/ampule1 mL/ampule1 mL/ampule
1 mg10 mg10 mg100 mg1 mg10 mg100 mg500 mg10 mg1 mg10 mg150 mg500 mg10 mg5 mg50 mg1 mg10 mg50 mg500 mg1 mg10 mg5 mg50 mg10 mg500 mg10 mg100 mg5 mg50 mg5 mg50 mg50 mg250 mg10 mg100 mg1 mg
Index description
AAMU (5-acetylamino-6-amino-3-methyluracil)AAMU (5-acetylamino-6-amino-3-methyluracil)AcyclovirAcyclovirAcyclovirAcyclovirAdefovirAdefovirAdefovirAdefovirAFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AFMU(5-acetylamino-6-formylamino-3-methyluracil)AmantadineAmantadineAmantadineAmantadine7-aminoclonazepam7-aminoclonazepam7-aminoclonazepam
7-aminoclonazepam7-aminoclonazepamAmodiaquineAmodiaquineAmodiaquineAmodiaquineAmoxicillinAmoxicillinAmoxicillinAmoxicillinAmoxicillinAmpicillinAmpicillinAmpicillinAtazanavirAtazanavirAtazanavirAtazanavirAtorvastatinAtorvastatinAtorvastatinAtorvastatinAzamulinAzamulinBenzbromaroneBenzbromarone(+/-)-N-3-benzylnirvanol(+/-)-N-3-benzylnirvanol(S)-(+)-N-3-benzylnirvanol(S)-(+)-N-3-benzylnirvanol(R)-(-)-N-3-benzylnirvanol(R)-(-)-N-3-benzylnirvanolBenzylpenicillinBenzylpenicillinBenzylpenicillinBenzylpenicillinBilirubin glucuronide
29www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-B385310-10
TRC-B689540TRC-B689540-100TRC-B689542TRC-B689542-10CERB-034
TRC-B689625TRC-B689625-10TRC-B689627TRC-B689627-10CERC-051TRC-C080100TRC-C080100-50TRC-C080102TRC-C080102-25CDX-00003145-001TRC-C175750TRC-C175752TRC-C175752-10CERC-053TRC-C175840TRC-C175840-10TRC-C175842TRC-C175842-10TRC-C175843TRC-C175843-10TRC-C183200TRC-C183200-50TRC-C183202TRC-C183202-10TRC-C235750TRC-C235750-100TRC-C235752TRC-C235752-10TRC-C237500TRC-C237500-1TRC-C242500TRC-C242500-10TRC-C277000TRC-C277000-25TRC-C380000TRC-C380000-2.5TRC-C380002TRC-C380002-10TRC-C428700TRC-C428700-100TRC-C428702TRC-C428702-10CERC-055TRC-C441650TRC-C441650-1TRC-C441652TRC-C441652-10TRC-C499500TRC-C499500-1TRC-C587250TRC-C587250-1TRC-C587252TRC-C587252-10TRC-C696302TRC-C696302-5CERC-017CERC-035TRC-C725004TRC-C725004-50TRC-C725005
Product description
Bilirubin Acyl-β-D-glucuronide (Mixture ofMonoglucuronides)Bufuralol, HydrochlorideBufuralol, HydrochlorideBufuralol-d9 HydrochlorideBufuralol-d9 HydrochlorideBupropion HCl, 1.0 mg/mL (as free base), inMethanolBupropion HydrochlorideBupropion HydrochlorideBupropion-d9 HydrochlorideBupropion-d9 HydrochlorideCaffeine, 1.0 mg/mL, in MethanolCaffeineCaffeineCaffeine-d9Caffeine-d9CaptoprilCaptoprilCaptopril-d7Captopril-d7Carbamazepine, 1.0 mg/mL, in MethanolCarbamazepineCarbamazepineCarbamazepine-13C,d2Carbamazepine-13C,d2Carbamazepine-d2Carbamazepine-d24-Carboxy Tolbutamide4-Carboxy Tolbutamide4-Carboxy Tolbutamide-d94-Carboxy Tolbutamide-d9CefadroxilCefadroxilCefadroxil-d4 (major)Cefadroxil-d4 (major)Cefamandole Sodium SaltCefamandole Sodium SaltCefazolin Sodium SaltCefazolin Sodium SaltCerivastatin, Sodium SaltCerivastatin, Sodium SaltChlorothiazideChlorothiazideChlorothiazide-13C,15N2Chlorothiazide-13C,15N2ChlorzoxazoneChlorzoxazoneChlorzoxazone-4,6,7-d3Chlorzoxazone-4,6,7-d3CimetidineCimetidineCimetidineCimetidine-d3Cimetidine-d3CisplatinCisplatin(+)-Clopidogrel Hydrogen Sulfate(+)-Clopidogrel Hydrogen Sulfaterac Clopidogrel-d4 Hydrogen Sulfaterac Clopidogrel-d4 Hydrogen SulfateCortisol-9,11,12,12-d4Cortisol-9,11,12,12-d4S-(±)-Cotinine-D3, 100 µg/mL, in MethanolS-(±)-Cotinine-D3, 1.0 mg/mL, in Methanolrac Cotininerac Cotininerac Cotinine-d3
Pack size
10 mg
10 mg100 mg1 mg10 mg1 mL/ampule
1 g10 g1 mg10 mg1 mL/ampule5 g50 g2.5 mg25 mg1 g10 g1 mg10 mg1 mL/ampule1 g10 g1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg10 mg100 mg1 mg10 mg100 mg1 g1 g10 g2.5 mg25 mg250 mg2.5 g1 mg10 mg10 mg100 mg1 mg10 mg250 mg100 mg1 g1 mg10 mg100 mg1 g100 mg1 g1 mg10 mg0.5 mg5 mg1 mL/ampule1 mL/ampule5 mg50 mg10 mg
Index description
Bilirubin glucuronide
BufuralolBufuralolBufuralolBufuralolBupropion
BupropionBupropionBupropionBupropionCaffeineCaffeineCaffeineCaffeineCaffeineCaptoprilCaptoprilCaptoprilCaptoprilCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarboxytolbutamideCarboxytolbutamideCarboxytolbutamideCarboxytolbutamideCefadroxilCefadroxilCefadroxilCefadroxilCefamandoleCefamandoleCefazolinCefazolinCerivastatinCerivastatinChlorothiazideChlorothiazideChlorothiazideChlorothiazideChlorzoxazoneChlorzoxazoneChlorzoxazoneChlorzoxazoneCimetidineCimetidineCimetidineCimetidineCimetidineCisplatinCisplatinClopidogrelClopidogrelClopidogrelClopidogrelCortisolCortisolCotinineCotinineCotinineCotinineCotinine
30 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-C725005-100CERC-073EPY0000438USP1158504TRC-D193250TRC-D193250-10TRC-D193255TRC-D193255-10TRC-D193260TRC-D193260-100TRC-D193262TRC-D193262-10TRC-D194500TRC-D194500-50TRC-D194502TRC-D194502-5TRC-D208700TRC-D208700-1TRC-D208702TRC-D208702-10TRC-D474000TRC-D474000-10TRC-D474010TRC-D474010-10TRC-D229650TRC-D229650-10TRC-D229652TRC-D229652-10CERD-039
CERD-040
TRC-D288825TRC-D288825-50TRC-D288827TRC-D288827-10TRC-D289475TRC-D289475-50TRC-D289477TRC-D289477-10CERD-903
CERD-906
TRC-D290050TRC-D290050-100TRC-D290052TRC-D290052-10TRC-D298800TRC-D298800-10TRC-D298802TRC-D298802-25CERD-013TRC-D299455TRC-D299455-1TRC-D299457TRC-D299457-50CERD-034
CERD-041TRC-D299485TRC-D299485-250TRC-D299487TRC-D299487-25CERD-028TRC-D436450TRC-D436450-100TRC-D436452
Product description
rac Cotinine-d3Coumarin, 1.0 mg/mL, in AcetonitrileCoumarinCyclosporineDapsoneDapsoneDapsone-D8 (Major)Dapsone-D8 (Major)Dapsone HydroxylamineDapsone HydroxylamineDapsone Hydroxylamine-D8 (Major)Dapsone Hydroxylamine-D8 (Major)Daunorubicin, HydrochlorideDaunorubicin, HydrochlorideDaunorubicin-13C,d3Daunorubicin-13C,d3Debrisoquin HemisulfateDebrisoquin HemisulfateDebrisoquin-13C,15N2 HemisulfateDebrisoquin-13C,15N2 HemisulfateDeferiproneDeferiproneDeferiprone 3-O-ß-D-GlucuronideDeferiprone 3-O-ß-D-GlucuronideDehydro FelodipineDehydro FelodipineDehydro Felodipine-d3Dehydro Felodipine-d3N-Desethylamodiaquine dihydrochloride, 1.0mg/mL (as free base), in MethanolN-Desethylamodiaquine-D5 dihydrochloride,100 µg/mL (as free base), in MethanolN-Desethyl AmodiaquineN-Desethyl AmodiaquineN-Desethyl Amodiaquine-d5N-Desethyl Amodiaquine-d5rac Desethyl Oxybutynin Hydrochloriderac Desethyl Oxybutynin HydrochlorideDesethyl Oxybutynin-d11 HydrochlorideDesethyl Oxybutynin-d11 HydrochlorideDesipramine-D3 HCl, 100 µg/mL (as free base),in MethanolDesipramine HCl, 1.0 mg/mL (as free base), inMethanolDesipramine HydrochlorideDesipramine HydrochlorideDesipramine-2,4,6,8-d4 HydrochlorideDesipramine-2,4,6,8-d4 HydrochlorideDexamethasoneDexamethasoneDexamethasone-d3Dexamethasone-d3Dextromethorphan, 1.0 mg/mL, in MethanolDextromethorphan Hydrobromide MonohydrateDextromethorphan Hydrobromide MonohydrateDextromethorphan-d3Dextromethorphan-d3Dextrorphan tartrate, 1.0 mg/mL (as free base),1 mL/ampule in MethanolDextrorphan-D3, 100 µg/mL, in MethanolDextrorphan, Tartrate SaltDextrorphan, Tartrate SaltDextrorphan-d3, Tartrate SaltDextrorphan-d3, Tartrate SaltDiclofenac sodiumDiclofenac Sodium SaltDiclofenac Sodium SaltDiclofenac-D4 (Major)
Pack size
100 mg1 mL/ampule80 mg50 mg1 g10 g1 mg10 mg10 mg100 mg1 mg10 mg5 mg50 mg0.5 mg5 mg100 mg1 g1 mg10 mg1 mg10 mg1 g10 g1 mg10 mg1 mg10 mg1 mL/ampule
1 mL/ampule
5 mg50 mg1 mg10 mg5 mg50 mg1 mg10 mg1 mL/ampule
1 mL/ampule
10 mg100 mg1 mg10 mg1 g10 g10 mg25 mg1 mL/ampule100 mg1 g5 mg50 mg1 mL/ampule
1 mL/ampule25 mg250 mg2.5 mg25 mg250 mg10 g100 g1 mg
Index description
CotinineCoumarinCoumarinCyclosporine ADapsoneDapsoneDapsoneDapsoneDapsonehydroxylamineDapsonehydroxylamineDapsonehydroxylamineDapsonehydroxylamineDaunorubicinDaunorubicinDaunorubicinDaunorubicinDebrisoquinDebrisoquinDebrisoquinDebrisoquinDeferiproneDeferiproneDeferiprone-3-O-ß-D-glucuronideDeferiprone-3-O-ß-D-glucuronideDehydrofelodipineDehydrofelodipineDehydrofelodipineDehydrofelodipineDesethylamodiaquine
Desethylamodiaquine
DesethylamodiaquineDesethylamodiaquineDesethylamodiaquineDesethylamodiaquineDesethyloxybutyninDesethyloxybutyninDesethyloxybutyninDesethyloxybutyninDesipramine
Desipramine
DesipramineDesipramineDesipramineDesipramineDexamethasoneDexamethasoneDexamethasoneDexamethasoneDextromethorphanDextromethorphanDextromethorphanDextromethorphanDextromethorphanDextrorphan
DextrorphanDextrorphanDextrorphanDextrorphanDextrorphanDiclofenacDiclofenacDiclofenacDiclofenac
31www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-D436452-10TRC-D436475TRC-D436475-10CERD-029TRC-D446575TRC-D446575-10TRC-D446577TRC-D446577-25TRC-D493450TRC-D493450-1TRC-D493452TRC-D493452-10EPD2960000MM0384.00TRC-D533782TRC-D533782-10TRC-D533790TRC-D533790-10TRC-D558000TRC-D558000-250TRC-D558002TRC-D558002-2.5TRC-E425000TRC-E425000-100TRC-E425002TRC-E425002-10TRC-E489000TRC-E489000-100TRC-E489002TRC-E489002-10TRC-E555250TRC-E555250-50TRC-E555252TRC-E555252-10TRC-E555253TRC-E555253-10TRC-E625000TRC-E625000-50TRC-E625002TRC-E625002-10TRC-E649950TRC-E649950-10TRC-E649952TRC-E649952-10TRC-E888000TRC-E888000-50TRC-E888002TRC-E888002-10TRC-E891725TRC-E891725-10TRC-E891727TRC-E891727-100TRC-E892875TRC-E892875-100TRC-E685100TRC-E685100-25TRC-E685102TRC-E685102-10TRC-E685115TRC-E685115-10CDX-00005365-025TRC-E933750TRC-E933750-1TRC-F232375TRC-F232375-1TRC-F232377TRC-F232377-10TRC-F322470
Product description
Diclofenac-D4 (Major)Diclofenac Acyl-β-D-glucuronideDiclofenac Acyl-β-D-glucuronideDigoxin, 1.0 mg/mL, in MethanolDigoxinDigoxinDigoxin-d3Digoxin-d3DisopyramideDisopyramideDisopyramide-d14 Tosylate SaltDisopyramide-d14 Tosylate SaltDopamine hydrochlorideDopamine HydrochlorideDopamine-d4 HydrochlorideDopamine-d4 HydrochlorideDopamine 3-β-D-GlucuronideDopamine 3-β-D-GlucuronideDoxorubicin, HydrochlorideDoxorubicin, HydrochlorideDoxorubicin-13C,d3Doxorubicin-13C,d3EfavirenzEfavirenzrac Efavirenz-d4rac Efavirenz-d4ElacridarElacridarElacridar-d4Elacridar-d4Enalapril MaleateEnalapril MaleateEnalapril-d5 Maleate SaltEnalapril-d5 Maleate SaltEnalapril-d3Enalapril-d3Erlotinib, Hydrochloride SaltErlotinib, Hydrochloride SaltErlotinib-d6, Hydrochloride SaltErlotinib-d6, Hydrochloride SaltErythromycinErythromycinErythromycin-13C,D3Erythromycin-13C,D317β-Estradiol17β-Estradiol17β-Estradiol-16,16,17-d317β-Estradiol-16,16,17-d37-Ethoxycoumarin7-Ethoxycoumarin7-Ethoxycoumarin-d57-Ethoxycoumarin-d57-Ethoxyresorufin7-EthoxyresorufinEthynyl EstradiolEthynyl EstradiolEthynyl Estradiol-2,4,16,16-d4Ethynyl Estradiol-2,4,16,16-d4Ethynyl Estradiol 3-SulfateEthynyl Estradiol 3-SulfateEtoposideEtoposideEtoposideFelodipineFelodipinerac Felodipine-d3rac Felodipine-d3Fexofenadine
Pack size
10 mg1 mg10 mg1 mL/ampule1 g10 g2.5 mg25 mg100 mg1 g1 mg10 mg50 mg500 mg1 mg10 mg1 mg10 mg25 mg250 mg0.25 mg2.5 mg10 mg100 mg1 mg10 mg10 mg100 mg1 mg10 mg5 g50 g1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg1 g10 g1 mg10 mg5 g50 g1 mg10 mg1 g10 g10 mg100 mg10 mg100 mg2.5 g25 g1 mg10 mg1 mg10 mg25 mg100 mg1 g100 mg1 g1 mg10 mg100 mg
Index description
DiclofenacDiclofenac acyl-β-D-glucuronideDiclofenac acyl-β-D-glucuronideDigoxinDigoxinDigoxinDigoxinDigoxinDisopyramideDisopyramideDisopyramideDisopyramideDopamineDopamineDopamineDopamineDopamine-3-β-D-glucuronideDopamine-3-β-D-glucuronideDoxorubicinDoxorubicinDoxorubicinDoxorubicinEfavirenzEfavirenzEfavirenzEfavirenzElacridarElacridarElacridarElacridarEnalaprilEnalaprilEnalaprilEnalaprilEnalaprilEnalaprilErlotinibErlotinibErlotinibErlotinibErythromycinErythromycinErythromycinErythromycinEstradiolEstradiolEstradiolEstradiol7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxyresorufin7-ethoxyresorufinEthynylestradiolEthynylestradiolEthynylestradiolEthynylestradiolEthynylestradiol 3-sulfateEthynylestradiol 3-sulfateEtoposideEtoposideEtoposideFelodipineFelodipineFelodipineFelodipineFexofenadine
32 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-F322470-1TRC-F322490TRC-F322490-1TRC-F322500TRC-F322500-10TRC-F421000TRC-F421000-1TRC-F421002TRC-F421002-10CERF-918
CERF-919
TRC-F597100TRC-F597100-1TRC-F597102TRC-F597102-10TRC-F598700TRC-F598700-50TRC-F598702TRC-F598702-50TRC-F598850TRC-F598850-100TRC-F598852TRC-F598852-10TRC-F601250TRC-F601250-5TRC-F601252TRC-F601252-10TRC-F603500TRC-F603500-1TRC-F603502TRC-F603502-10TRC-G235000TRC-G235000-10TRC-G235002TRC-G235002-10TRC-G304000TRC-G304000-50TRC-G305750TRC-G305750-100TRC-G305752TRC-G305752-50CDX-00008061-100CERH-004CERH-010CERH-049NMIAD 785BCERH-051
TRC-H830480TRC-H830480-10TRC-H830482
TRC-H830482-5
CERH-062
CERH-066
TRC-H830675TRC-H830675-100TRC-H830677TRC-H830677-10TRC-D452230TRC-D452230-100CERH-063
Product description
FexofenadineFexofenadine, HydrochlorideFexofenadine, HydrochlorideFexofenadine-D6Fexofenadine-D6FluconazoleFluconazoleFluconazole-d4Fluconazole-d4Fluoxetine HCl, 1.0 mg/mL (as free base),in MethanolFluoxetine-D6 Oxalate, 100 µg/mL (as freebase), in MethanolFluoxetine, HydrochlorideFluoxetine, HydrochlorideFluoxetine-d5 HydrochlorideFluoxetine-d5 HydrochlorideFlurbiprofenFlurbiprofenFlurbiprofen-d3Flurbiprofen-d3FlutamideFlutamideFlutamide-d7Flutamide-d7Fluvastatin, Sodium SaltFluvastatin, Sodium SaltFluvastatin-D8 (Major), Sodium SaltFluvastatin-D8 (Major), Sodium Salt(E)-Fluvoxamine Maleate(E)-Fluvoxamine Maleate(E)-Fluvoxamine-d3 Maleate(E)-Fluvoxamine-d3 MaleateGanciclovirGanciclovirGanciclovir-d5Ganciclovir-d5GefitinibGefitinibGemfibrozilGemfibrozilGemfibrozil-d6Gemfibrozil-d6HecogeninHydromorphone, 1.0 mg/mL, in MethanolHydromorphone-D3, 1.0 mg/mL, in MethanolHydromorphone-D6, 100 µg/mL, in MethanolHydromorphone HCl*Hydromorphone-3-β-D-glucuronide, 100 µg/mL,in Methanol:Water (1:1)1’-Hydroxy Bufuralol1’-Hydroxy Bufuralol1’-Hydroxybufuralol-d9 (Mixture ofDiastereomers)1’-Hydroxybufuralol-d9 (Mixture ofDiastereomers)(±)-Hydroxybupropion-D6, 100 µg/mL, inAcetonitrile(±)-Hydroxybupropion, 1.0 mg/mL, inAcetonitrileHydroxy BupropionHydroxy BupropionHydroxy Bupropion-d6Hydroxy Bupropion-d66',7'-Dihydroxy Bergamottin6',7'-Dihydroxy Bergamottin6-Hydroxychlorzoxazone, 100 µg/mL, inMethanol
Pack size
1 g100 mg1 g1 mg10 mg100 mg1 g1 mg10 mg1 mL/ampule
1 mL/ampule
100 mg1 g1 mg10 mg5 g50 g5 mg50 mg10 mg100 mg1 mg10 mg500 mg5 g1 mg10 mg100 mg1 g1 mg10 mg1 g10 g1 mg10 mg5 mg50 mg10 g100 g5 mg50 mg100 mg1 mL/ampule1 mL/ampule1 mL/ampule20 mg1 mL/ampule
1 mg10 mg0.5 mg
5 mg
1 mL/ampule
1 mL/ampule
10 mg100 mg1 mg10 mg10 mg100 mg1 mL/ampule
Index description
FexofenadineFexofenadineFexofenadineFexofenadineFexofenadineFluconazoleFluconazoleFluconazoleFluconazoleFluoxetine
Fluoxetine
FluoxetineFluoxetineFluoxetineFluoxetineFlurbiprofenFlurbiprofenFlurbiprofenFlurbiprofenFlutamideFlutamideFlutamideFlutamideFluvastatinFluvastatinFluvastatinFluvastatinFluvoxamineFluvoxamineFluvoxamineFluvoxamineGanciclovirGanciclovirGanciclovirGanciclovirGefitinibGefitinibGemfibrozilGemfibrozilGemfibrozilGemfibrozilHecogeninHydromorphoneHydromorphoneHydromorphoneHydromorphoneHydromorphone-3-glucuronide
1-hydroxybufuralol1-hydroxybufuralol1-hydroxybufuralol
1-hydroxybufuralol
Hydroxybupropion
Hydroxybupropion
HydroxybupropionHydroxybupropionHydroxybupropionHydroxybupropion6´,7´-dihydroxybergamottin6´,7´-dihydroxybergamottin6-hydroxychlorzoxazone
33www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
CERH-064
TRC-H825120TRC-H825120-50TRC-H825122TRC-H825122-2.5TRC-H922300TRC-H922300-25TRC-H922302TRC-H922302-10TRC-H924500TRC-H924500-100TRC-H924505TRC-H924505-50TRC-H924510TRC-H924510-10CERH-060CERH-061
TRC-H924875TRC-H924875-25TRC-H924877TRC-H924877-2.5TRC-H924878TRC-H924878-2.5TRC-H924890TRC-H924890-50TRC-H924892
TRC-H924892-2.5
TRC-H924880
TRC-H924880-10
TRC-H924882
TRC-H924882-10
TRC-H924883TRC-H924883-10TRC-H933875TRC-H933875-100TRC-H933877TRC-H933877-10TRC-H936750TRC-H936750-50TRC-H936752TRC-H936752-10TRC-H936760TRC-H936760-10CERH-052CERH-053
TRC-H825225TRC-H825225-10TRC-H825227TRC-H825227-10TRC-H825228TRC-H825228-10TRC-H941825TRC-H941825-10TRC-H941827TRC-H941827-10TRC-H942440TRC-H942440-50TRC-H942442TRC-H942442-10
Product description
6-Hydroxychlorzoxazone-D2,15N, 100 µg/mL,in Methanol6-Hydroxy Chlorzoxazone6-Hydroxy Chlorzoxazone6-Hydroxy Chlorzoxazone-13C66-Hydroxy Chlorzoxazone-13C66β-Hydroxy Cortisol6β-Hydroxy Cortisol6β-Hydroxy Cortisol-d46β-Hydroxy Cortisol-d4(3'R,5'S)-3'-Hydroxycotinine(3'R,5'S)-3'-Hydroxycotinine(3S,5S)-3'-Hydroxycotinine(3S,5S)-3'-Hydroxycotininetrans-3'-Hydroxycotinine, Methyl-d3trans-3'-Hydroxycotinine, Methyl-d37-Hydroxycoumarin, 1.0 mg/mL, in Acetonitrile7-Hydroxycoumarin-13C6, 100 µg/mL, inAcetonitrile7-Hydroxy Coumarin7-Hydroxy Coumarin7-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C67-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-13C6 β-D-Glucuronide7-Hydroxy Coumarin-13C6 β-D-Glucuroniderac 4-Hydroxydebrisoquine Hemisulfaterac 4-Hydroxydebrisoquine Hemisulfaterac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfaterac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfate3-Hydroxy Desloratadine3-Hydroxy Desloratadine3-Hydroxy Desloratadine-d43-Hydroxy Desloratadine-d43-Hydroxy Desloratadine β-D-Glucuronide3-Hydroxy Desloratadine β-D-Glucuronide4'-Hydroxydiclofenac, 100 µg/mL, in Acetonitrile4'-Hydroxydiclofenac-13C6, 100 µg/mL, inMethanol4’-Hydroxy Diclofenac4’-Hydroxy Diclofenac4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-13C64’-Hydroxy Diclofenac-13C6rac 8-Hydroxy Efavirenzrac 8-Hydroxy Efavirenzrac 8-Hydroxy Efavirenz-d4rac 8-Hydroxy Efavirenz-d44’-Hydroxy Flurbiprofen4’-Hydroxy Flurbiprofen4’-Hydroxy Flurbiprofen-d34’-Hydroxy Flurbiprofen-d3
Pack size
1 mL/ampule
5 mg50 mg0.25 mg2.5 mg5 mg25 mg1 mg10 mg10 mg100 mg5 mg50 mg1 mg10 mg1 mL/ampule1 mL/ampule
2.5 g25 g0.25 mg2.5 mg0.25 mg2.5 mg5 mg50 mg0.25 mg
2.5 mg
1 mg
10 mg
1 mg
10 mg
1 mg10 mg10 mg100 mg1 mg10 mg5 mg50 mg1 mg10 mg1 mg10 mg1 mL/ampule1 mL/ampule
1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg
Index description
6-hydroxychlorzoxazone
6-hydroxychlorzoxazone6-hydroxychlorzoxazone6-hydroxychlorzoxazone6-hydroxychlorzoxazone6β-hydroxycortisol6β-hydroxycortisol6β-hydroxycortisol6β-hydroxycortisol3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine3-hydroxycotinine7-hydroxycoumarin7-hydroxycoumarin
7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate
7-hydroxycoumarin sulfate
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide7-hydroxycoumarin-glucuronide(±)-4-hydroxydebrisoquin sulfate(±)-4-hydroxydebrisoquin sulfate(±)-4-hydroxydebrisoquin sulfate(±)-4-hydroxydebrisoquin sulfateHydroxydesloratadineHydroxydesloratadineHydroxydesloratadineHydroxydesloratadine3-hydroxydesloratadine-β-D-glucuronide3-hydroxydesloratadine-β-D-glucuronide4’-hydroxydiclofenac4’-hydroxydiclofenac
4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac8-hydroxyefavirenz8-hydroxyefavirenz8-hydroxyefavirenz8-hydroxyefavirenz4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen
34 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-H944875TRC-H944875-250TRC-H944877TRC-H944877-25TRC-H948390TRC-H948390-50TRC-H948392
TRC-H948392-10
CERH-902CERH-921
TRC-H948420TRC-H948420-50TRC-H948422TRC-H948422-10TRC-H948430TRC-H948430-10TRC-H948425TRC-H948425-50TRC-H948427TRC-H948427-5TRC-H948435TRC-H948435-10CDX-00008685-010TRC-H948863TRC-H948863-10TRC-H948864TRC-H948864-10TRC-H950770TRC-H950770-10TRC-H953230TRC-H953230-10TRC-H953232TRC-H953232-10TRC-H953440TRC-H953440-10TRC-H953450TRC-H953450-10TRC-H954730TRC-H954730-10TRC-H954757TRC-H954757-100TRC-H956755TRC-H956755-10CERH-059CERT-034
TRC-H956750TRC-H956750-50TRC-H956752TRC-H956752-10CERH-054CERH-055
TRC-H969850TRC-H969850-50TRC-H969852TRC-H969852-10TRC-H971330TRC-H971330-10TRC-H996100TRC-H996100-50TRC-H996120TRC-H996120-50TRC-H996130TRC-H996130-50
Product description
(+/-) - 4’-HydroxyMephenytoin(+/-) - 4’-HydroxyMephenytoin(+/-)-4’-Hydroxy Mephenytoin-d3(+/-)-4’-Hydroxy Mephenytoin-d3α-Hydroxy Metoprolol (Mixture of Diastereomers)α-Hydroxy Metoprolol (Mixture of Diastereomers)α-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)α-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)α-Hydroxymidazolam, 100 µg/mL, in Methanolα-Hydroxymidazolam-D4, 100 µg/mL, inMethanol1’-Hydroxy Midazolam1’-Hydroxy Midazolam1’-Hydroxymidazolam-13C31’-Hydroxymidazolam-13C31’-Hydroxymidazolam-β-D-glucuronide1’-Hydroxymidazolam-β-D-glucuronide4-Hydroxy Midazolam4-Hydroxy Midazolam4-Hydroxy Midazolam-d54-Hydroxy Midazolam-d54-Hydroxymidazolam β-D-Glucuronide4-Hydroxymidazolam β-D-Glucuronide21-Hydroxyprogesterone5-Hydroxy Omeprazole Sodium Salt5-Hydroxy Omeprazole Sodium Salt5-Hydroxy Omeprazole-d3 Sodium Salt5-Hydroxy Omeprazole-d3 Sodium Salt4-Hydroxy Propofol4-Hydroxy Propofol(3S)-3-Hydroxy Quinidine(3S)-3-Hydroxy Quinidine(3S)-3-Hydroxy Quinidine-vinyl-d3(3S)-3-Hydroxy Quinidine-vinyl-d35-Hydroxy Rosiglitazone5-Hydroxy Rosiglitazone5-Hydroxy Rosiglitazone Sulfate5-Hydroxy Rosiglitazone Sulfate4'-Hydroxy Tamoxifen4'-Hydroxy Tamoxifen4-Hydroxy Tamoxifen Ethyl-d54-Hydroxy Tamoxifen Ethyl-d56α-Hydroxy Testosterone6α-Hydroxy Testosterone6β-Hydroxytestosterone, 100 µg/mL, in Methanol6β-Hydroxytestosterone-D3, 100 µg/mL, inMethanol6β-Hydroxy Testosterone6β-Hydroxy Testosterone6β-Hydroxy Testosterone-d36β-Hydroxy Testosterone-d34-Hydroxytolbutamide, 1.0 mg/mL, in Acetonitrile4-Hydroxytolbutamide-D9, 100 µg/mL, inAcetonitrileHydroxy TolbutamideHydroxy TolbutamideHydroxy Tolbutamide-d9Hydroxy Tolbutamide-d94-Hydroxy Triazolam4-Hydroxy Triazolam4’-Hydroxy Warfarin4’-Hydroxy Warfarin6-Hydroxy Warfarin6-Hydroxy Warfarin7-Hydroxy Warfarin7-Hydroxy Warfarin
Pack size
25 mg250 mg2.5 mg25 mg5 mg50 mg1 mg
10 mg
1 mL/ampule1 mL/ampule
5 mg50 mg1 mg10 mg1 mg10 mg5 mg50 mg0.5 mg5 mg1 mg10 mg10 mg1 mg10 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mL/ampule1 mL/ampule
5 mg50 mg1 mg10 mg1 mL/ampule1 mL/ampule
5 mg50 mg1 mg10 mg1 mg10 mg5 mg50 mg5 mg50 mg5 mg50 mg
Index description
4-hydroxymephenytoin4-hydroxymephenytoin4-hydroxymephenytoin4-hydroxymephenytoinα-hydroxymetoprololα-hydroxymetoprololα-hydroxymetoprolol
α-hydroxymetoprolol
1'-hydroxymidazolam1'-hydroxymidazolam
1'-hydroxymidazolam1'-hydroxymidazolam1'-hydroxymidazolam1'-hydroxymidazolam1'-hydroxymidazolam-β-D-glucuronide1'-hydroxymidazolam-β-D-glucuronide4-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam-β-D-glucuronide4-hydroxymidazolam-β-D-glucuronide21-hydroxyprogesterone5-hydroxyomeprazole5-hydroxyomeprazole5-hydroxyomeprazole5-hydroxyomeprazole4-hydroxypropofol4-hydroxypropofol(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidine5-hydroxyrosiglitazone5-hydroxyrosiglitazone5-hydroxyrosiglitazone5-hydroxyrosiglitazone4-hydroxytamoxifen4-hydroxytamoxifen4-hydroxytamoxifen4-hydroxytamoxifen6α-hydroxytestosterone6α-hydroxytestosterone6β-hydroxytestosterone6β-hydroxytestosterone
6β-hydroxytestosterone6β-hydroxytestosterone6β-hydroxytestosterone6β-hydroxytestosterone4-hydroxytolbutamide4-hydroxytolbutamide
4-hydroxytolbutamide4-hydroxytolbutamide4-hydroxytolbutamide4-hydroxytolbutamide4-hydroxytriazolam4-hydroxytriazolam4-hydroxywarfarin4-hydroxywarfarin6-hydroxywarfarin6-hydroxywarfarin7-hydroxywarfarin7-hydroxywarfarin
35www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-H996140TRC-H996140-50TRC-H996160TRC-H996160-50TRC-I465983TRC-I465983-25TRC-I525000TRC-I525000-50TRC-I525002TRC-I525002-10EPI0500000TRC-I821452TRC-I821452-10USP1349706TRC-I937500TRC-I937500-500TRC-I937502TRC-I937502-10TRC-K186000TRC-K186000-5TRC-K186002TRC-K186002-25CERL-012TRC-L175000TRC-L175000-10TRC-L175002TRC-L175002-25TRC-L175800TRC-L175800-50TRC-L175802TRC-L175802-5CDX-00012080-010CDX-00012080-100TRC-L469450TRC-L469450-250TRC-L469452TRC-L469452-10TRC-M218000TRC-M218000-1TRC-M218002TRC-M218002-10TRC-M225450TRC-M225450-25TRC-M258812TRC-M258812-10TRC-M258815TRC-M260675TRC-M260675-10TRC-M260677TRC-M260677-50TRC-M260795TRC-M260795-100TRC-M294460TRC-M294460-2TRC-M338575TRC-M338575-100TRC-M338577TRC-M338577-10CERM-123
TRC-M338790TRC-M338790-1TRC-M338792TRC-M338792-10CERM-908CERM-918
TRC-M343000
Product description
8-Hydroxy Warfarin8-Hydroxy Warfarin10-Hydroxy Warfarin10-Hydroxy WarfarinImipramine-d6Imipramine-d6Indinavir SulfateIndinavir SulfateIndinavir-d6Indinavir-d6IsoniazidIsoniazid-d4Isoniazid-d4IsoniazidItraconazoleItraconazoleItraconazole-d5Itraconazole-d5KetoconazoleKetoconazoleKetoconazole-d8Ketoconazole-d8LansoprazoleLansoprazoleLansoprazoleLansoprazole-d4Lansoprazole-d4Lapatinib DitosylateLapatinib DitosylateLapatinib-13C2,15N DitosylateLapatinib-13C2,15N DitosylateLauric AcidLauric AcidLoperamide, HydrochlorideLoperamide, HydrochlorideLoperamide-d6 HydrochlorideLoperamide-d6 HydrochlorideMemantine, HydrochlorideMemantine, HydrochlorideMemantine-d6, HydrochlorideMemantine-d6, Hydrochloride6-Mercaptopurine Monohydrate6-Mercaptopurine MonohydrateMetformin-d6, HydrochlorideMetformin-d6, HydrochlorideMetformin, HydrochlorideMethotrexateMethotrexateMethotrexate-methyl-d3Methotrexate-methyl-d3MethoxsalenMethoxsalen3-Methylcholanthrene3-Methylcholanthrene1-Methylxanthine1-Methylxanthine1-Methylxanthine-d31-Methylxanthine-d3Metoprolol Tartrate, 1.0 mg/mL (as free base),in Methanolrac Metoprolol Hemi (+)-Tartraterac Metoprolol Hemi (+)-Tartraterac Metoprolol-d7rac Metoprolol-d7Midazolam, 1.0 mg/mL, in MethanolMidazolam-D4 maleate, 100 µg/mL (as freebase), in MethanolMidazolam
Pack size
5 mg50 mg5 mg50 mg2.5 mg25 mg5 mg50 mg1 mg10 mg100 mg1 mg10 mg200 mg50 mg500 mg1 mg10 mg500 mg5 g2.5 mg25 mg250 mg1 g10 g2.5 mg25 mg5 mg50 mg0.5 mg5 mg10 mg100 mg25 mg250 mg1 mg10 mg100 mg1 g1 mg10 mg2.5 g25 g1 mg10 mg100 g1 g10 g5 mg50 mg10 mg100 mg200 mg2 g10 mg100 mg1 mg10 mg1 mL/ampule
100 mg1 g1 mg10 mg1 mL/ampule1 mL/ampule
100 mg
Index description
8-hydroxywarfarin8-hydroxywarfarin10-hydroxywarfarin10-hydroxywarfarinImipramineImipramineIndinavirIndinavirIndinavirIndinavirIsoniazidIsoniazidIsoniazidIsoniazidItraconazoleItraconazoleItraconazoleItraconazoleKetoconazoleKetoconazoleKetoconazoleKetoconazoleLansoprazoleLansoprazoleLansoprazoleLansoprazoleLansoprazoleLapatinibLapatinibLapatinibLapatinibLauric acidLauric acidLoperamideLoperamideLoperamideLoperamideMemantineMemantineMemantineMemantine6-mercaptopurine6-mercaptopurineMetforminMetforminMetforminMethotrexateMethotrexateMethotrexateMethotrexateMethoxsalenMethoxsalen3-methylcholanthrene3-methylcholanthrene1-methylxanthine1-methylxanthine1-methylxanthine1-methylxanthineMetoprolol
MetoprololMetoprololMetoprololMetoprololMidazolamMidazolam
Midazolam
36 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-M343000-1TRC-M343002TRC-M343002-10TRC-M373425TRC-M373425-1TRC-M373427TRC-M373427-10TRC-A168435TRC-A168435-100TRC-A168437TRC-A168437-10TRC-M568000TRC-M568000-100TRC-M568002TRC-M568002-10MM0037.00
CERM-017CERM-018CERM-031
TRC-M652310TRC-M652310-10TRC-M652312TRC-M652312-10TRC-A168325TRC-A168325-10TRC-A187850TRC-A187850-100TRC-A187852TRC-A187852-10CERN-042TRC-N377520TRC-N377527TRC-N377527-10TRC-N377530TRC-N377530-10CDX-00014014-001CDX-00014014-010CDX-00014015-001CDX-00014015-010TRC-D230930TRC-D230930-50TRC-N389750TRC-N389750-100TRC-N389752TRC-N389752-10CERN-048TRC-N412420TRC-N412420-2.5TRC-N412423TRC-N412423-100TRC-N412427TRC-N412427-25TRC-N457000TRC-N457000-100TRC-N457002TRC-N457002-10CDX-00014497-001USP1475008TRC-D292127TRC-D292127-10TRC-D294740TRC-D294740-25TRC-D294742TRC-D294742-10TRC-O253750TRC-O253750-1
Product description
MidazolamMidazolam-d5 (Major)Midazolam-d5 (Major)MitoxantroneMitoxantroneMitoxantrone-d8Mitoxantrone-d8N-Acetyl DapsoneN-Acetyl DapsoneN-Acetyl Dapsone-D8 (Major)N-Acetyl Dapsone-D8 (Major)Montelukast Sodium SaltMontelukast Sodium SaltMontelukast-d6, Sodium SaltMontelukast-d6, Sodium SaltMorphine Hydrochloride Trihydrate [ControlledSubstance]Morphine-3-β-D-glucuronide-D3Morphine-3-β-D-glucuronide (0.1 mg/ml)Morphine-3-β-D-glucuronide (1.0 mg/ml) inMethanolMorphine 6-β-D-GlucuronideMorphine 6-β-D-GlucuronideMorphine-d3 6-β-D-GlucuronideMorphine-d3 6-β-D-GlucuronideN-Acetyl-4-aminosalicylic AcidN-Acetyl-4-aminosalicylic AcidN-Acetyl SulfamethazineN-Acetyl SulfamethazineN-Acetyl Sulfamethazine-d4N-Acetyl Sulfamethazine-d4Naproxen, 1.0 mg/mL, in Methanol(S)-Naproxenrac Naproxen-d3rac Naproxen-d3Naproxen Acyl-β-D-glucuronideNaproxen Acyl-β-D-glucuronideα-Naphthoflavoneα-Naphthoflavoneβ-Naphthoflavoneβ-NaphthoflavoneN-Demethyl ErythromycinN-Demethyl ErythromycinNelfinavir, MesylateNelfinavir, MesylateNelfinavir-d3Nelfinavir-d3(±)-Nicotine-D4, 100 µg/mL, in Acetonitrile(+/-)-Nicotine(+/-)-Nicotine(+/-)-Nicotine-3’-d3(+/-)-Nicotine-3’-d3Nicotine-d4Nicotine-d4NifedipineNifedipineNifedipine-d6Nifedipine-d6NootkatoneNovobiocinrac O-Desmethyl Naproxen-d3rac O-Desmethyl Naproxen-d3O-Desmethyl Tramadol HydrochlorideO-Desmethyl Tramadol Hydrochloriderac O-Desmethyl Tramadol-d6rac O-Desmethyl Tramadol-d6OlanzapineOlanzapine
Pack size
1 g1 mg10 mg100 mg1 g1 mg10 mg10 mg100 mg1 mg10 mg10 mg100 mg1 mg10 mg250 mg
1 mL/ampule1 mL/ampule1 mL/ampule
1 mg10 mg1 mg10 mg1 g10 g10 mg100 mg1 mg10 mg1 mL/ampule25 g1 mg10 mg1 mg10 mg1 g10 mg1 g10 mg5 mg50 mg10 mg100 mg1 mg10 mg1 mL/ampule250 mg2.5 g10 mg100 mg2.5 mg25 mg10 mg100 mg1 mg10 mg1 g200 mg1 mg10 mg2.5 mg25 mg1 mg10 mg100 mg1 g
Index description
MidazolamMidazolamMidazolamMitoxantroneMitoxantroneMitoxantroneMitoxantroneMonoacetyldapsoneMonoacetyldapsoneMonoacetyldapsoneMonoacetyldapsoneMontelukastMontelukastMontelukastMontelukastMorphine
Morphine-3-β-D-glucuronideMorphine-3-β-D-glucuronideMorphine-3-β-D-glucuronide
Morphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideN-acetyl-4-aminosalicylic acidN-acetyl-4-aminosalicylic acidN-acetylsulfamethazineN-acetylsulfamethazineN-acetylsulfamethazineN-acetylsulfamethazineNaproxenNaproxenNaproxenNaproxenNaproxen acyl-b-D-glucuronideNaproxen acyl-b-D-glucuronideα-naphthoflavoneα-naphthoflavoneβ-naphthoflavoneβ-naphthoflavoneN-demethylerythromycinN-demethylerythromycinNelfinavirNelfinavirNelfinavirNelfinavirNicotineNicotineNicotineNicotineNicotineNicotineNicotineNifedipineNifedipineNifedipineNifedipineNootkatoneNovobiocinO-desmethylnaproxenO-desmethylnaproxenO-desmethyltramadolO-desmethyltramadolO-desmethyltramadolO-desmethyltramadolOlanzapineOlanzapine
37www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-O253752TRC-O253752-10TRC-O253755TRC-O253755-10TRC-O253757TRC-O253757-2.5TRC-O550001TRC-O550001-100TRC-O550002TRC-O550002-10CERO-021TRC-O635000TRC-O635000-5TRC-O635002TRC-O635002-10EPO0200000TRC-O868525TRC-O868525-25TRC-O868527TRC-O868527-10TRC-H948890TRC-H948890-10TRC-H948892TRC-H948892-5TRC-H948895TRC-H948895-2.5TRC-H948897TRC-H948897-2.5CDX-00016011-001CDX-00016011-005TRC-P132500TRC-P132500-250TRC-P132502TRC-P132502-5MM 0094.03USP1026401CERA-064CERP-909CERP-917TRC-A161220TRC-A161220-50TRC-A161222TRC-A161222-100TRC-A161230TRC-A161230-100TRC-A161232TRC-A161232-10TRC-A161223
TRC-A161223-10
TRC-P192500TRC-P192500-2TRC-P192502TRC-P192502-10CERP-061U-RCC-216CERNMID748CERP-003
CERP-006
CERP-007TRC-P295500TRC-P296900TRC-P296900-100CERP-008
Product description
Olanzapine-methyl-d3Olanzapine-methyl-d3Olanzapine GlucuronideOlanzapine GlucuronideOlanzapine-methyl-d3 GlucuronideOlanzapine-methyl-d3 GlucuronideOlmesartan AcidOlmesartan AcidOlmesartan-d6Olmesartan-d6Omeprazole, 1.0 mg/mL, in MethanolOmeprazoleOmeprazoleOmeprazole-d3Omeprazole-d3OuabainOxybutynin ChlorideOxybutynin ChlorideOxybutynin-d11 ChlorideOxybutynin-d11 Chloride6α-Hydroxy Paclitaxel6α-Hydroxy Paclitaxel6α-Hydroxy Paclitaxel-d56α-Hydroxy Paclitaxel-d53’-p-Hydroxy Paclitaxel3’-p-Hydroxy Paclitaxel3’-p-Hydroxy Paclitaxel-d53’-p-Hydroxy Paclitaxel-d5Paclitaxel C13 Labeled (for Non-Human use only)Paclitaxel C13 Labeled (for non-human use only)PaclitaxelPaclitaxelPaclitaxel-d5Paclitaxel-d54-Aminobenzoic AcidAminosalicylic AcidAcetaminophen, 1.0 mg/mL, in MethanolAcetaminophen-D4, 100 µg/mL, in MethanolAcetaminophen-D4, 1.0 mg/mL, in MethanolAcetaminophenAcetaminophenAcetaminophen-D4 (Major)Acetaminophen-D4 (Major)4-Acetaminophen Sulfate Potassium Salt4-Acetaminophen Sulfate Potassium Salt4-Acetaminophen-d3 Sulfate Potassium Salt4-Acetaminophen-d3 Sulfate Potassium SaltAcetaminophen Glutathione
Acetaminophen Glutathione
ParaxanthineParaxanthineParaxanthine-1-methyl-d3Paraxanthine-1-methyl-d3Phenacetin, 1.0 mg/mL, in AcetonitrilePhenacetinPhencyclidine hydrochloridePCP-D5 (Phencyclidine-D5), 100 µg/mL, inMethanolPCP-D5 (Phencyclidine-D5), 1.0 mg/mL, inMethanolPCP (Phencyclidine), 1.0 mg/mL, in MethanolPhencyclidine HydrochloridePhenformin HydrochloridePhenformin HydrochloridePhenobarbital, 1.0 mg/mL, in Methanol
Pack size
1 mg10 mg1 mg10 mg0.25 mg2.5 mg10 mg100 mg1 mg10 mg1 mL/ampule i500 mg5 g1 mg10 mg150 mg2.5 g25 g1 mg10 mg1 mg10 mg0.5 mg5 mg1 mg2.5 mg1 mg2.5 mg1 mg5 mg25 mg250 mg1 mg5 mg100 mg125 mg1 mL/ampule1 mL/ampule1 mL/ampule5 g50 g10 mg100 mg10 mg100 mg1 mg10 mg1 mg
10 mg
200 mg2 g1 mg10 mg1 mL/ampule100 mg50 mg1 mL/ampule
1 mL/ampule
1 mL/ampule10 mg10 g100 g1 mL/ampule
Index description
OlanzapineOlanzapineOlanzapine GlucuronideOlanzapine GlucuronideOlanzapine GlucuronideOlanzapine GlucuronideOlmesartanOlmesartanOlmesartanOlmesartanOmeprazoleOmeprazoleOmeprazoleOmeprazoleOmeprazoleOuabainOxybutyninOxybutyninOxybutyninOxybutynin6α-hydroxypaclitaxel6α-hydroxypaclitaxel6α-hydroxypaclitaxel6α-hydroxypaclitaxelp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelp-aminobenzoic acidp-aminosalicylic acidParacetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol-glutathione (Acetaminophen-glutathione)Paracetamol-glutathione (Acetaminophen-glutathione)ParaxanthineParaxanthineParaxanthineParaxanthinePhenacetinPhenacetinPhencyclidinePhencyclidine
Phencyclidine
PhencyclidinePhencyclidinePhenforminPhenforminPhenobarbital
38 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
CERP-017
CERP-019
TRC-P316760TRC-P316760-1TRC-P316762TRC-P316762-50USP1526007CERP-063TRC-D491652TRC-D491652-25TRC-P441500TRC-P441500-100TRC-P441502TRC-P441502-10TRC-P471000TRC-P471000-1TRC-P471002TRC-P471002-10TRC-P531000TRC-P531000-100TRC-P689600TRC-P689600-10TRC-P689602TRC-P689602-10TRC-P702000TRC-P702000-1TRC-P702002TRC-P702002-10TRC-P702325TRC-P702325-100TRC-P755000TRC-P755002TRC-P755002-10EPP3050000USP1563502MM0461.00CDX-00017030-025CDX-00017030-100TRC-Q685000TRC-Q685000-100TRC-Q685002TRC-Q685002-10TRC-Q694000TRC-Q694000-10TRC-Q694002TRC-Q694002-10TRC-R100000TRC-R100000-10TRC-R100001TRC-R100001-10TRC-R144500TRC-R144500-1TRC-R144502TRC-R144502-10CDX-00018040-025CDX-00018040-100TRC-R146500TRC-R250200TRC-R250200-10TRC-R250202TRC-R250202-10TRC-R508000TRC-R508000-25TRC-R508002TRC-R508002-10TRC-R508500
Product description
Phenobarbital-D5 (deuterium label on sidechain), 1.0 mg/mL, in MethanolPhenobarbital-D5 (deuterium label on ring), 1.0mg/mL, in MethanolPhenobarbitalPhenobarbitalPhenobarbital-ethyl-d5Phenobarbital-ethyl-d5Phenoxybenzamine HClPhenytoin, 1.0 mg/mL5,5-Diphenyl-d10-hydantoin5,5-Diphenyl-d10-hydantoinPilocarpine HydrochloridePilocarpine HydrochloridePilocarpine-d3 HydrochloridePilocarpine-d3 HydrochloridePioglitazone HydrochloridePioglitazone HydrochloridePioglitazone-d4Pioglitazone-d4Pitavastatin CalciumPitavastatin CalciumPosaconazolePosaconazolePosaconazole-d4Posaconazole-d4Pravastatin SodiumPravastatin SodiumPravastatin-D3 Sodium SaltPravastatin-D3 Sodium SaltPrazosin HydrochloridePrazosin HydrochlorideProbenecidProbenecid-d14Probenecid-d14Procainamide hydrochlorideProcainamide HClPropofolQuercetinQuercetinQuinidineQuinidineQuinidine-d3Quinidine-d3QuinineQuinineQuinine-d3Quinine-d3Raloxifene, HydrochlorideRaloxifene, HydrochlorideRaloxifene-d4Raloxifene-d4RepaglinideRepaglinideRepaglinide-ethyl-d5Repaglinide-ethyl-d5ReserpineReserpineResorufin sodium salt, 90%all-trans Retinoic Acidall-trans Retinoic Acidall-trans Retinoic Acid-d5all-trans Retinoic Acid-d5RifampicinRifampicinRifampicin-d3Rifampicin-d3Rifapentine
Pack size
1 mL/ampule
1 mL/ampule
100 mg1 g5 mg50 mg250 mg1 mL/ampule2.5 mg25 mg10 mg100 mg1 mg10 mg100 mg1 g1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg100 mg1 g1 mg10 mg10 mg100 mg100 g1 mg10 mg100 mg200 mg250 mg25 mg100 mg10 g100 g1 mg10 mg1 g10 g1 mg10 mg1 g10 g1 mg10 mg100 mg1 g1 mg10 mg25 mg100 mg1 g1 g10 g1 mg10 mg2.5 g25 g1 mg10 mg10 mg
Index description
Phenobarbital
Phenobarbital
PhenobarbitalPhenobarbitalPhenobarbitalPhenobarbitalPhenoxy-benzaminePhenytoinPhenytoinPhenytoinPilocarpinePilocarpinePilocarpinePilocarpinePioglitazonePioglitazonePioglitazonePioglitazonePitavastatinPitavastatinPosaconazolePosaconazolePosaconazolePosaconazolePravastatinPravastatinPravastatinPravastatinPrazosinPrazosinProbenecidProbenecidProbenecidProcainamideProcainamidePropofolQuercetinQuercetinQuinidineQuinidineQuinidineQuinidineQuinineQuinineQuinineQuinineRaloxifeneRaloxifeneRaloxifeneRaloxifeneRepaglinideRepaglinideRepaglinideRepaglinideReserpineReserpineResorufinRetinoic acidRetinoic acidRetinoic acidRetinoic acidRifampicinRifampicinRifampicinRifampicinRifapentine
39www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-R508200TRC-R508200-1TRC-R508500-100TRC-R535000TRC-R535000-100TRC-R535002TRC-R535002-5TRC-R535003TRC-R535003-5TRC-R693500TRC-R693500-250TRC-R693502TRC-R693502-10TRC-R700500TRC-R700500-100TRC-R700502TRC-R700502-10TRC-D292070TRC-D292070-250TRC-S135000TRC-S135000-100TRC-S135002TRC-S135002-10CDX-00019180-100CERS-006TRC-S280000TRC-S280000-1TRC-S280002TRC-S280002-10TRC-M225000TRC-M225000-100TRC-S589950TRC-S589950-50TRC-S589952TRC-S589952-10TRC-S699072TRC-S699072-10TRC-S699074TRC-S699074-100TRC-S699084TRC-S699084-100EPS2159000USP1637008TRC-S699115TRC-S699115-10USP1642700USP1642802CDX-00020070-010CDX-00020070-025EPY0000648TRC-T017000TRC-T017000-500TRC-T017002TRC-T017002-10TRC-T017305TRC-T017305-10TRC-T114500TRC-T114500-100CERNMID508CERNMID644TRC-T155000TRC-T155000-100TRC-T155002TRC-T155002-50CERIMPC-051-01USP1660000USP1664000TRC-T425600
Product description
Rifamycin SV SodiumRifamycin SV SodiumRifapentineRitonavirRitonavirRitonavir-d6Ritonavir-d6Ritonavir-13C3Ritonavir-13C3Rosiglitazone MaleateRosiglitazone MaleateRosiglitazone-d3Rosiglitazone-d3Rosuvastatin, Calcium SaltRosuvastatin, Calcium SaltRosuvastatin-d6, Sodium SaltRosuvastatin-d6, Sodium SaltS-(+)-N-Desmethyl MephenytoinS-(+)-N-Desmethyl MephenytoinSaquinavir, MesylateSaquinavir, MesylateSaquinavir-d9Saquinavir-d9Serotonin hydrochlorideSertraline, 1.0 mg/mL, in MethanolSertraline, HydrochlorideSertraline, Hydrochloriderac Sertraline-d3 Hydrochloriderac Sertraline-d3 Hydrochloride(S)-Mephenytoin(S)-MephenytoinSN-38SN-38SN-38-d3SN-38-d3Sulfamethazine-d4Sulfamethazine-d4SulfamethazineSulfamethazineSulfasalazineSulfasalazineSulfinpyrazoneSulfinpyrazoneD,L-SulforaphaneD,L-SulforaphaneTacrine HClTacrolimusTaxol CTaxol CTelmisartanTelmisartanTelmisartanTelmisartan-d3Telmisartan-d3TemocaprilatTemocaprilatTerfenadineTerfenadineTestosterone sulfate19-d3-TestosteroneTestosteroneTestosteroneTestosterone-d3Testosterone-d3Theophylline, 1.0 mg/mL, in MethanolThioguanineThiotepaThyroxine
Pack size
100 mg1 g100 mg10 mg100 mg0.5 mg5 mg0.5 mg5 mg25 mg250 mg1 mg10 mg10 mg100 mg1 mg10 mg25 mg250 mg10 mg100 mg1 mg10 mg100 mg1 mL/ampule100 mg1 g1 mg10 mg10 mg100 mg5 mg50 mg1 mg10 mg1 mg10 mg10 mg100 mg10 g100 g30 mg200 mg1 g10 g500 mg150 mg10 mg25 mg30 mg50 mg500 mg1 mg10 mg1 mg10 mg10 g100 g1 mg1 mg10 g100 g5 mg50 mg1 mL/ampule200 mg500 mg1 g
Index description
RifamycinRifamycinRifapentineRitonavirRitonavirRitonavirRitonavirRitonavirRitonavirRosiglitazoneRosiglitazoneRosiglitazoneRosiglitazoneRosuvastatinRosuvastatinRosuvastatinRosuvastatinS-(+)-N-desmethyl mephenytoinS-(+)-N-desmethyl mephenytoinSaquinavirSaquinavirSaquinavirSaquinavirSerotoninSertralineSertralineSertralineSertralineSertralineS-mephenytoinS-mephenytoinSN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SulfamethazineSulfamethazineSulfamethazineSulfamethazineSulfasalazineSulfasalazineSulfinpyrazoneSulfinpyrazoneSulforaphaneSulforaphaneTacrineTacrolimusTaxolTaxolTelmisartanTelmisartanTelmisartanTelmisartanTelmisartanTemocaprilatTemocaprilatTerfenadineTerfenadineTestosteroneTestosteroneTestosteroneTestosteroneTestosteroneTestosteroneTheophyllineThioguanineThiotepaThyroxine
40 www.lgcstandards.com
Catalogue (labelled, unlabelled and fluorescent)Use the ‘Index description’ found in the ‘Enzyme and Transporter’ tabs to locate the most suitable product.
LGC catalogue no.
TRC-T425600-10TRC-T425602TRC-T425602-5TRC-T438325TRC-T438325-50CERT-036TRC-T542500TRC-T542500-10TRC-T542502TRC-T542502-10CERT-029
TRC-T712480TRC-T712480-10TRC-T712500TRC-T712500-10TRC-P319680TRC-P319680-1TRC-P319682
TRC-P319682-10
CERT-908CERT-910TRC-T767380TRC-T767380-100CDX-00020640-001TRC-T779200TRC-T779200-100TRC-T779202TRC-T779202-10TRC-T795615TRC-T795615-100TRC-T795616TRC-T795616-10TRC-T795617TRC-T795617-10TRC-T795618TRC-T795618-10TRC-T892500TRC-T892500-100USP1697000TRC-T894600TRC-V085000TRC-V085000-1TRC-V085002TRC-V085002-10TRC-V094750TRC-V094750-100TRC-V094752TRC-V094752-50TRC-V095750TRC-V095750-100TRC-V095752TRC-V095752-10CERV-002
TRC-V125000TRC-V125000-50TRC-V125002TRC-V125002-50CDX-00022518-005CDX-00022518-010TRC-V314000TRC-V314000-200EPZ1900000USP1724500
Product description
ThyroxineThyroxine-13C6Thyroxine-13C6Ticlopidine, HydrochlorideTiclopidine, HydrochlorideTolbutamide, 1.0 mg/mL, in AcetonitrileTopotecan HydrochlorideTopotecan HydrochlorideTopotecan-d6Topotecan-d6Tramadol-13C, D3 HCl, 100 µg/mL (as freebase), in MethanolTramadol-d6 HydrochlorideTramadol-d6 HydrochlorideTramadol HydrochlorideTramadol Hydrochloridetrans 2-Phenylcyclopropylamine Hydrochloridetrans 2-Phenylcyclopropylamine Hydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochlorideTriazolam-D4, 100 µg/mL, in MethanolTriazolam, 1.0 mg/mL, in MethanolTriazolamTriazolamTricinTrifluoperazine DihydrochlorideTrifluoperazine DihydrochlorideTrifluoperazine-d3 DihydrochlorideTrifluoperazine-d3 DihydrochlorideTrimethoprimTrimethoprimTrimethoprim-13C3Trimethoprim-13C3Trimethoprim-d9 (Major)Trimethoprim-d9 (Major)Trimethoprim-d3Trimethoprim-d3TroglitazoneTroglitazoneTroleandomycinTryptamineValacyclovir, HydrochlorideValacyclovir, HydrochlorideValacyclovir-d4, HydrochlorideValacyclovir-d4, HydrochlorideValproic AcidValproic AcidValproic Acid-d6Valproic Acid-d6ValsartanValsartanValsartan-d3Valsartan-d3Verapamil HCl, 1.0 mg/mL (as free base), inMethanolVerapamil HydrochlorideVerapamil HydrochlorideVerapamil-d6 HydrochlorideVerapamil-d6 HydrochlorideVinblastine SulfateVinblastine SulfateVinblastine SulfateVinblastine SulfateZidovudineZidovudine
Pack size
10 g1 mg5 mg5 g50 g1 mL/ampule1 mg10 mg1 mg10 mg1 mL/ampule
1 mg10 mg1 g10 g100 mg1 g1 mg
10 mg
1 mL/ampule1 mL/ampule10 mg100 mg1 mg10 mg100 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg250 mg50 g100 mg1 g1 mg10 mg10 g100 g5 mg50 mg10 mg100 mg1 mg10 mg1 mL/ampule
5 g50 g5 mg50 mg5 mg10 mg20 mg200 mg60 mg400 mg
Index description
ThyroxineThyroxineThyroxineTiclopidineTiclopidineTolbutamideTopotecanTopotecanTopotecanTopotecanTramadol
TramadolTramadolTramadolTramadolTranylcypromineTranylcypromineTranylcypromine
Tranylcypromine
TriazolamTriazolamTriazolamTriazolamTricinTrifluoperazineTrifluoperazineTrifluoperazineTrifluoperazineTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTroglitazoneTroglitazoneTroleandomycinTryptamineValacyclovirValacyclovirValacyclovirValacyclovirValproic acidValproic acidValproic acidValproic acidValsartanValsartanValsartanValsartanVerapamil
VerapamilVerapamilVerapamilVerapamilVinblastineVinblastineVinblastineVinblastineZidovudine (azidothymidine, AZT)Zidovudine (azidothymidine, AZT)
Fluorescent products
Fluorescent products onlyQuick reference catalogue listing of fluorescent reagents only.
LGC catalogue no.
CERC-073EPY0000438TRC-E891725TRC-E891725-10TRC-E891727TRC-E891727-100TRC-E892875TRC-E892875-100CERH-060CERH-061
TRC-H924875TRC-H924875-25TRC-H924877TRC-H924877-2.5TRC-H924878TRC-H924878-2.5TRC-H924890TRC-H924890-50TRC-H924892
TRC-H924892-2.5
TRC-H924880
TRC-H924880-10
TRC-H924882
TRC-H924882-10
TRC-H924883TRC-H924883-10TRC-R146500
Product description
Coumarin, 1.0 mg/mL, in AcetonitrileCoumarin7-Ethoxycoumarin7-Ethoxycoumarin7-Ethoxycoumarin-d57-Ethoxycoumarin-d57-Ethoxyresorufin7-Ethoxyresorufin7-Hydroxycoumarin, 1.0 mg/mL, in Acetonitrile7-Hydroxycoumarin-13C6, 100 µg/mL, inAcetonitrile7-Hydroxy Coumarin7-Hydroxy Coumarin7-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C67-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin Sulfate Potassium Salt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin β-D-Glucuronide SodiumSalt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-13C6 β-D-Glucuronide7-Hydroxy Coumarin-13C6 β-D-GlucuronideResorufin sodium salt, 90%
Pack size
1 mL/ampule80 mg1 g10 g10 mg100 mg10 mg100 mg1 mL/ampule1 mL/ampule
2.5 g25 g0.25 mg2.5 mg0.25 mg2.5 mg5 mg50 mg0.25 mg
2.5 mg
1 mg
10 mg
1 mg
10 mg
1 mg10 mg1 g
Index description
CoumarinCoumarin7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)7-ethoxyresorufin7-ethoxyresorufin7-hydroxycoumarin7-hydroxycoumarin
7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate7-hydroxycoumarin sulfate
7-hydroxycoumarin sulfate
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide7-hydroxycoumarin-glucuronideResorufin
42 www.lgcstandards.com
Labelled products
44 www.lgcstandards.com
Labelled products onlyQuick reference catalogue listing for labelled compounds only.
LGC catalogue no.
TRC-A192402TRC-A192402-10TRC-A247502TRC-A247502-2.5TRC-A168213
TRC-A168213-10
TRC-A575822TRC-A575822-10CERA-917
TRC-A634202TRC-A634202-10TRC-A634237-10TRC-A634238TRC-A634238-10TRC-A634302TRC-A790052TRC-A790052-10TRC-A791752TRC-A791752-10TRC-B288600TRC-B288600-100TRC-B689542TRC-B689542-10TRC-B689627TRC-B689627-10TRC-C080102TRC-C080102-25TRC-C175752TRC-C175752-10TRC-C175842TRC-C175842-10TRC-C175843TRC-C175843-10TRC-C183202TRC-C183202-10TRC-C235752TRC-C235752-10TRC-C380002TRC-C380002-10TRC-C428702TRC-C428702-10TRC-C441652TRC-C441652-10TRC-C587252TRC-C587252-10TRC-C696302TRC-C696302-5CERC-017CERC-035TRC-C725005TRC-C725005-100TRC-D193255TRC-D193255-10TRC-D193262TRC-D193262-10TRC-D194502TRC-D194502-5TRC-D208702TRC-D208702-10TRC-D474010TRC-D474010-10TRC-D229652TRC-D229652-10CERD-040
Product description
Acyclovir-d4Acyclovir-d4Adefovir-d4Adefovir-d45-Acetylamino-6-formylamino-3-methyluracil-d3
5-Acetylamino-6-formylamino-3-methyluracil-d3
Amantadine-d15 HydrochlorideAmantadine-d15 Hydrochloride7-Aminoclonazepam-D4, 100 µg/mL, inAcetonitrileAmodiaquin-d10Amodiaquin-d10Amoxicillin-13C6Amoxicillin-d4Amoxicillin-d4Ampicillin-d5 (Mixture of Diastereomers)Atazanavir-d5Atazanavir-d5Atorvastatin-d5, Sodium SaltAtorvastatin-d5, Sodium SaltBenzylpenicillinate-d7, Potassium SaltBenzylpenicillinate-d7, Potassium SaltBufuralol-d9 HydrochlorideBufuralol-d9 HydrochlorideBupropion-d9 HydrochlorideBupropion-d9 HydrochlorideCaffeine-d9Caffeine-d9Captopril-d7Captopril-d7Carbamazepine-13C,d2Carbamazepine-13C,d2Carbamazepine-d2Carbamazepine-d24-Carboxy Tolbutamide-d94-Carboxy Tolbutamide-d9Cefadroxil-d4 (major)Cefadroxil-d4 (major)Chlorothiazide-13C,15N2Chlorothiazide-13C,15N2Chlorzoxazone-4,6,7-d3Chlorzoxazone-4,6,7-d3Cimetidine-d3Cimetidine-d3rac Clopidogrel-d4 Hydrogen Sulfaterac Clopidogrel-d4 Hydrogen SulfateCortisol-9,11,12,12-d4Cortisol-9,11,12,12-d4(±)-Cotinine-D3, 100 µg/mL, in Methanol(±)-Cotinine-D3, 1.0 mg/mL, in MethanolCotinine-methyl-d3Cotinine-methyl-d3Dapsone-D8 (Major)Dapsone-D8 (Major)Dapsone Hydroxylamine-D8 (Major)Dapsone Hydroxylamine-D8 (Major)Daunorubicin-13C,d3Daunorubicin-13C,d3Debrisoquin-13C,15N2 HemisulfateDebrisoquin-13C,15N2 HemisulfateDeferiprone 3-O-ß-D-GlucuronideDeferiprone 3-O-ß-D-GlucuronideDehydro Felodipine-d3Dehydro Felodipine-d3N-Desethylamodiaquine-D5 dihydrochloride,100 µg/mL (as free base), in Methanol
Pack size
1 mg10 mg2.5 mg25 mg1 mg
10 mg
1 mg10 mg1 mL/ampule
1 mg10 mg10 mg1 mg10 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg0.5 mg5 mg1 mL/ampule1 mL/ampule10 mg100 mg1 mg10 mg1 mg10 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule
Index description
AcyclovirAcyclovirAdefovirAdefovirAFMU (5-acetylamino-6-formylamino-3-methyluracil)AFMU (5-acetylamino-6-formylamino-3-methyluracil)AmantadineAmantadine7-aminoclonazepam
AmodiaquineAmodiaquineAmoxicillinAmoxicillinAmoxicillinAmpicillinAtazanavirAtazanavirAtorvastatinAtorvastatinBenzylpenicillinBenzylpenicillinBufuralolBufuralolBupropionBupropionCaffeineCaffeineCaptoprilCaptoprilCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarboxytolbutamideCarboxytolbutamideCefadroxilCefadroxilChlorothiazideChlorothiazideChlorzoxazoneChlorzoxazoneCimetidineCimetidineClopidogrelClopidogrelCortisolCortisolCotinineCotinineCotinineCotinineDapsoneDapsoneDapsonehydroxylamineDapsonehydroxylamineDaunorubicinDaunorubicinDebrisoquinDebrisoquinDeferiprone-3-O-ß-D-glucuronideDeferiprone-3-O-ß-D-glucuronideDehydrofelodipineDehydrofelodipineDesethylamodiaquine
45www.lgcstandards.com
Labelled products onlyQuick reference catalogue listing for labelled compounds only.
LGC catalogue no.
TRC-D288827TRC-D288827-10TRC-D289477TRC-D289477-10CERD-903
TRC-D290052TRC-D290052-10TRC-D298802TRC-D298802-25TRC-D299457TRC-D299457-50CERD-041TRC-D299487TRC-D299487-25TRC-D436452TRC-D436452-10TRC-D446577TRC-D446577-25TRC-D493452TRC-D493452-10TRC-D533782TRC-D533782-10TRC-D533790TRC-D533790-10TRC-D558002TRC-D558002-2.5TRC-E425002TRC-E425002-10TRC-E489002TRC-E489002-10TRC-E555252TRC-E555252-10TRC-E555253TRC-E555253-10TRC-E625002TRC-E625002-10TRC-E649952TRC-E649952-10TRC-E888002TRC-E888002-10TRC-E891727TRC-E891727-100TRC-E685102TRC-E685102-10TRC-F232377TRC-F232377-10TRC-F322500TRC-F322500-10TRC-F421002TRC-F421002-10CERF-919
TRC-F597102TRC-F597102-10TRC-F598702TRC-F598702-50TRC-F598852TRC-F598852-10TRC-F601252TRC-F601252-10TRC-F603502TRC-F603502-10TRC-G235002TRC-G235002-10TRC-G305752TRC-G305752-50CERH-006
Product description
N-Desethyl Amodiaquine-d5N-Desethyl Amodiaquine-d5Desethyl Oxybutynin-d11 HydrochlorideDesethyl Oxybutynin-d11 HydrochlorideDesipramine-D3 HCl, 100 µg/mL (as freebase), in MethanolDesipramine-2,4,6,8-d4 HydrochlorideDesipramine-2,4,6,8-d4 HydrochlorideDexamethasone-d3Dexamethasone-d3Dextromethorphan-d3Dextromethorphan-d3Dextrorphan-D3, 100 µg/mL, in MethanolDextrorphan-d3, Tartrate SaltDextrorphan-d3, Tartrate SaltDiclofenac-D4 (Major)Diclofenac-D4 (Major)Digoxin-d3Digoxin-d3Disopyramide-d14 Tosylate SaltDisopyramide-d14 Tosylate SaltDopamine-d4 HydrochlorideDopamine-d4 HydrochlorideDopamine 3-β-D-GlucuronideDopamine 3-β-D-GlucuronideDoxorubicin-13C,d3Doxorubicin-13C,d3rac Efavirenz-d4rac Efavirenz-d4Elacridar-d4Elacridar-d4Enalapril-d5 Maleate SaltEnalapril-d5 Maleate SaltEnalapril-d3Enalapril-d3Erlotinib-d6, Hydrochloride SaltErlotinib-d6, Hydrochloride SaltErythromycin-13C,D3Erythromycin-13C,D317β-Estradiol-16,16,17-d317β-Estradiol-16,16,17-d37-Ethoxycoumarin-d57-Ethoxycoumarin-d5Ethynyl Estradiol-2,4,16,16-d4Ethynyl Estradiol-2,4,16,16-d4rac Felodipine-d3rac Felodipine-d3Fexofenadine-D6Fexofenadine-D6Fluconazole-d4Fluconazole-d4Fluoxetine-D6 Oxalate, 100 µg/mL (as freebase), in MethanolFluoxetine-d5 HydrochlorideFluoxetine-d5 HydrochlorideFlurbiprofen-d3Flurbiprofen-d3Flutamide-d7Flutamide-d7Fluvastatin-D8 (Major), Sodium SaltFluvastatin-D8 (Major), Sodium Salt(E)-Fluvoxamine-d3 Maleate(E)-Fluvoxamine-d3 MaleateGanciclovir-d5Ganciclovir-d5Gemfibrozil-d6Gemfibrozil-d6Hydromorphone-D3, 100 µg/mL, in Methanol
Pack size
1 mg10 mg1 mg10 mg1 mL/ampule
1 mg10 mg10 mg25 mg5 mg50 mg1 mL/ampule2.5 mg25 mg1 mg10 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg0.25 mg2.5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg10 mg100 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule
1 mg10 mg5 mg50 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mL/ampule
Index description
DesethylamodiaquineDesethylamodiaquineDesethyloxybutyninDesethyloxybutyninDesipramine
DesipramineDesipramineDexamethasoneDexamethasoneDextromethorphanDextromethorphanDextrorphanDextrorphanDextrorphanDiclofenacDiclofenacDigoxinDigoxinDisopyramideDisopyramideDopamineDopamineDopamine-3-β-D-glucuronideDopamine-3-β-D-glucuronideDoxorubicinDoxorubicinEfavirenzEfavirenzElacridarElacridarEnalaprilEnalaprilEnalaprilEnalaprilErlotinibErlotinibErythromycinErythromycinEstradiolEstradiol7-ethoxycoumarin (7-EC)7-ethoxycoumarin (7-EC)EthynylestradiolEthynylestradiolFelodipineFelodipineFexofenadineFexofenadineFluconazoleFluconazoleFluoxetine
FluoxetineFluoxetineFlurbiprofenFlurbiprofenFlutamideFlutamideFluvastatinFluvastatinFluvoxamineFluvoxamineGanciclovirGanciclovirGemfibrozilGemfibrozilHydromorphone
46 www.lgcstandards.com
Labelled products onlyQuick reference catalogue listing for labelled compounds only.
LGC catalogue no.
CERH-010CERH-049CERH-062
CERH-066TRC-H830482TRC-H830482-5TRC-H830677TRC-H830677-10TRC-H922302TRC-H922302-10TRC-H924510TRC-H924510-10CERH-061
TRC-H924877TRC-H924877-2.5TRC-H924878TRC-H924878-2.5TRC-H924892
TRC-H924892-2.5
TRC-H924882
TRC-H924882-10
TRC-H924883TRC-H924883-10TRC-H933877TRC-H933877-10TRC-H936752TRC-H936752-10CERH-064
TRC-H825122TRC-H825122-2.5CERH-053
TRC-H825227TRC-H825227-10TRC-H825228TRC-H825228-10TRC-H941827TRC-H941827-10TRC-H942442TRC-H942442-10TRC-H944877TRC-H944877-25CERH-921
TRC-H948422TRC-H948422-10TRC-H948427TRC-H948427-5TRC-H948864TRC-H948864-10TRC-H948892TRC-H948892-5TRC-H954757TRC-H954757-100CERT-034
TRC-H956752TRC-H956752-10CERH-055
TRC-H969852
Product description
Hydromorphone-D3, 1.0 mg/mL, in MethanolHydromorphone-D6, 100 µg/mL, in Methanol(±)-Hydroxybupropion-D6, 100 µg/mL, inAcetonitrile(±)-Hydroxybupropion, 1.0 mg/mL, in Acetonitrile1’-Hydroxybufuralol-d9 (Mixture of Diastereomers)1’-Hydroxybufuralol-d9 (Mixture of Diastereomers)Hydroxy Bupropion-d6Hydroxy Bupropion-d66β-Hydroxy Cortisol-d46β-Hydroxy Cortisol-d4trans-3'-Hydroxycotinine, Methyl-d3trans-3'-Hydroxycotinine, Methyl-d37-Hydroxycoumarin-13C6, 100 µg/mL, inAcetonitrile7-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C37-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C67-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-13C6 Sulfate PotassiumSalt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-d5 β-D-GlucuronideSodium Salt7-Hydroxy Coumarin-13C6 β-D-Glucuronide7-Hydroxy Coumarin-13C6 β-D-Glucuroniderac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfaterac 4-Hydroxydebrisoquine-13C,15N2 Hemisulfate3-Hydroxy Desloratadine-d43-Hydroxy Desloratadine-d46-Hydroxychlorzoxazone-D2,15N, 100 µg/mL,in Methanol6-Hydroxy Chlorzoxazone-13C66-Hydroxy Chlorzoxazone-13C64'-Hydroxydiclofenac-13C6, 100 µg/mL, inMethanol4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-D4 (Major)4’-Hydroxy Diclofenac-13C64’-Hydroxy Diclofenac-13C6rac 8-Hydroxy Efavirenz-d4rac 8-Hydroxy Efavirenz-d44’-Hydroxy Flurbiprofen-d34’-Hydroxy Flurbiprofen-d3(+/-)-4’-Hydroxy Mephenytoin-d3(+/-)-4’-Hydroxy Mephenytoin-d3α-Hydroxymidazolam-D4, 100 µg/mL, inMethanol1’-Hydroxymidazolam-13C31’-Hydroxymidazolam-13C34-Hydroxy Midazolam-d54-Hydroxy Midazolam-d55-Hydroxy Omeprazole-d35-Hydroxy Omeprazole-d36α-Hydroxy Paclitaxel-d56α-Hydroxy Paclitaxel-d54-Hydroxy Tamoxifen Ethyl-d54-Hydroxy Tamoxifen Ethyl-d56β-Hydroxytestosterone-D3, 100 µg/mL, inMethanol6β-Hydroxy Testosterone-d36β-Hydroxy Testosterone-d34-Hydroxytolbutamide-D9, 100 µg/mL, inAcetonitrileHydroxy Tolbutamide-d9
Pack size
1 mL/ampule1 mL/ampule1 mL/ampule
1 mL/ampule0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule
0.25 mg2.5 mg0.25 mg2.5 mg0.25 mg
2.5 mg
1 mg
10 mg
1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule
0.25 mg2.5 mg1 mL/ampule
1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg2.5 mg25 mg1 mL/ampule
1 mg10 mg0.5 mg5 mg0.5 mg5 mg0.5 mg5 mg10 mg100 mg1 mL/ampule
1 mg10 mg1 mL/ampule
1 mg
Index description
HydromorphoneHydromorphoneHydroxybupropion
Hydroxybupropion1-hydroxybufuralol1-hydroxybufuralolHydroxybupropionHydroxybupropion6β-hydroxycortisol6β-hydroxycortisol3-hydroxycotinine3-hydroxycotinine7-hydroxycoumarin
7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin7-hydroxycoumarin sulfate
7-hydroxycoumarin sulfate
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide
7-hydroxycoumarin-glucuronide7-hydroxycoumarin-glucuronide(±)-4-hydroxydebrisoquin sulfate(±)-4-hydroxydebrisoquin sulfateHydroxydesloratadineHydroxydesloratadine6-hydroxychlorzoxazone
6-hydroxychlorzoxazone6-hydroxychlorzoxazone4’-hydroxydiclofenac
4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac4’-hydroxydiclofenac8-hydroxyefavirenz8-hydroxyefavirenz4’-hydroxyflurbiprofen4’-hydroxyflurbiprofen4-hydroxymephenytoin4-hydroxymephenytoin1'-hydroxymidazolam
1'-hydroxymidazolam1'-hydroxymidazolam4-hydroxymidazolam4-hydroxymidazolam5-hydroxyomeprazole5-hydroxyomeprazole6α-hydroxypaclitaxel6α-hydroxypaclitaxel4-hydroxytamoxifen4-hydroxytamoxifen6β-hydroxytestosterone
6β-hydroxytestosterone6β-hydroxytestosterone4-hydroxytolbutamide
4-hydroxytolbutamide
47www.lgcstandards.com
Labelled products onlyQuick reference catalogue listing for labelled compounds only.
LGC catalogue no.
TRC-H969852-10TRC-H953232TRC-H953232-10TRC-I465983TRC-I465983-25TRC-I525002TRC-I525002-10TRC-I821452TRC-I821452-10TRC-I937502TRC-I937502-10TRC-K186002TRC-K186002-25TRC-L175002TRC-L175002-25TRC-L175802TRC-L175802-5TRC-L469452TRC-L469452-10TRC-M218002TRC-M218002-10TRC-M258812TRC-M258812-10TRC-M260677TRC-M260677-50TRC-M338577TRC-M338577-10TRC-M338792TRC-M338792-10CERM-918
TRC-M343002TRC-M343002-10TRC-M373427TRC-M373427-10TRC-A168437TRC-A168437-10TRC-M568002TRC-M568002-10CERM-017TRC-M652312TRC-M652312-10TRC-A187852TRC-A187852-10TRC-N377527TRC-N377527-10TRC-N389752TRC-N389752-10CERN-048TRC-N412423TRC-N412423-100TRC-N412427TRC-N412427-25TRC-N457002TRC-N457002-10TRC-D292127TRC-D292127-10TRC-D294742TRC-D294742-10TRC-O253752TRC-O253752-10TRC-O253757TRC-O253757-2.5TRC-O550002TRC-O550002-10TRC-O635002TRC-O635002-10TRC-O868527
Product description
Hydroxy Tolbutamide-d9(3S)-3-Hydroxy Quinidine-vinyl-d3(3S)-3-Hydroxy Quinidine-vinyl-d3Imipramine-d6Imipramine-d6Indinavir-d6Indinavir-d6Isoniazid-d4Isoniazid-d4Itraconazole-d5Itraconazole-d5Ketoconazole-d8Ketoconazole-d8Lansoprazole-d4Lansoprazole-d4Lapatinib-13C2,15N DitosylateLapatinib-13C2,15N DitosylateLoperamide-d6 HydrochlorideLoperamide-d6 HydrochlorideMemantine-d6, HydrochlorideMemantine-d6, HydrochlorideMetformin-d6, HydrochlorideMetformin-d6, HydrochlorideMethotrexate-methyl-d3Methotrexate-methyl-d31-Methylxanthine-d31-Methylxanthine-d3rac Metoprolol-d7rac Metoprolol-d7Midazolam-D4 maleate, 100 µg/mL (as freebase), in MethanolMidazolam-d5 (Major)Midazolam-d5 (Major)Mitoxantrone-d8Mitoxantrone-d8N-Acetyl Dapsone-D8 (Major)N-Acetyl Dapsone-D8 (Major)Montelukast-d6, Sodium SaltMontelukast-d6, Sodium SaltMorphine-3-β-D-glucuronide-D3Morphine-d3 6-β-D-GlucuronideMorphine-d3 6-β-D-GlucuronideN-Acetyl Sulfamethazine-d4N-Acetyl Sulfamethazine-d4rac Naproxen-d3rac Naproxen-d3Nelfinavir-d3Nelfinavir-d3(±)-Nicotine-D4, 100 µg/mL, in Acetonitrile(+/-)-Nicotine-3’-d3(+/-)-Nicotine-3’-d3Nicotine-d4Nicotine-d4Nifedipine-d6Nifedipine-d6rac O-Desmethyl Naproxen-d3rac O-Desmethyl Naproxen-d3rac O-Desmethyl Tramadol-d6rac O-Desmethyl Tramadol-d6Olanzapine-methyl-d3Olanzapine-methyl-d3Olanzapine-methyl-d3 GlucuronideOlanzapine-methyl-d3 GlucuronideOlmesartan-d6Olmesartan-d6Omeprazole-d3Omeprazole-d3Oxybutynin-d11 Chloride
Pack size
10 mg1 mg10 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg2.5 mg25 mg2.5 mg25 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg1 mg10 mg1 mL/ampule
1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mL/ampule10 mg100 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg0.25 mg2.5 mg1 mg10 mg1 mg10 mg1 mg
Index description
4-hydroxytolbutamide(3S)-3-hydroxyquinidine(3S)-3-hydroxyquinidineImipramineImipramineIndinavirIndinavirIsoniazidIsoniazidItraconazoleItraconazoleKetoconazoleKetoconazoleLansoprazoleLansoprazoleLapatinibLapatinibLoperamideLoperamideMemantineMemantineMetforminMetforminMethotrexateMethotrexate1-methylxanthine1-methylxanthineMetoprololMetoprololMidazolam
MidazolamMidazolamMitoxantroneMitoxantroneMonoacetyldapsoneMonoacetyldapsoneMontelukastMontelukastMorphine-3-β-D-glucuronideMorphine-6-β-D-glucuronideMorphine-6-β-D-glucuronideN-acetylsulfamethazineN-acetylsulfamethazineNaproxenNaproxenNelfinavirNelfinavirNicotineNicotineNicotineNicotineNicotineNifedipineNifedipineO-desmethylnaproxenO-desmethylnaproxenO-desmethyltramadolO-desmethyltramadolOlanzapineOlanzapineOlanzapineOlanzapineOlmesartanOlmesartanOmeprazoleOmeprazoleOxybutynin
48 www.lgcstandards.com
Labelled products onlyQuick reference catalogue listing for labelled compounds only.
LGC catalogue no.
TRC-O868527-10TRC-H948897TRC-H948897-2.5CDX-00016011-001CDX-00016011-005TRC-P132502TRC-P132502-5CERP-909CERP-917TRC-A161222TRC-A161222-100TRC-A161232TRC-A161232-10TRC-P192502TRC-P192502-10CERP-003
CERP-006
CERP-017
CERP-019
TRC-P316762TRC-P316762-50TRC-D491652TRC-D491652-25TRC-P441502TRC-P441502-10TRC-P471002TRC-P471002-10TRC-P689602TRC-P689602-10TRC-P702002TRC-P702002-10TRC-P755002TRC-P755002-10TRC-Q685002TRC-Q685002-10TRC-694002TRC-694002-10TRC-Q694002TRC-Q694002-10TRC-R100001TRC-R100001-10TRC-R144502TRC-R144502-10TRC-R250202TRC-R250202-10TRC-R508002TRC-R508002-10TRC-R535002TRC-R535002-5TRC-R535003TRC-R535003-5TRC-R693502TRC-R693502-10TRC-R700502TRC-R700502-10TRC-S135002TRC-S135002-10TRC-S280002TRC-S280002-10TRC-S589952TRC-S589952-10TRC-S699072TRC-S699072-10TRC-T017002
Product description
Oxybutynin-d11 Chloride3’-p-Hydroxy Paclitaxel-d53’-p-Hydroxy Paclitaxel-d5Paclitaxel C13 Labeled for Non-Human use onlyPaclitaxel C13 Labeled (for non-human use only)Paclitaxel-d5Paclitaxel-d5Acetaminophen-D4, 100 µg/mL, in MethanolAcetaminophen-D4, 1.0 mg/mL, in MethanolAcetaminophen-D4 (Major)Acetaminophen-D4 (Major)4-Acetaminophen-d3 Sulfate Potassium Salt4-Acetaminophen-d3 Sulfate Potassium SaltParaxanthine-1-methyl-d3Paraxanthine-1-methyl-d3PCP-D5 (Phencyclidine-D5), 100 µg/mL, inMethanolPCP-D5 (Phencyclidine-D5), 1.0 mg/mL, inMethanolPhenobarbital-D5 (deuterium label on side chain),1.0 mg/mL, in MethanolPhenobarbital-D5 (deuterium label on ring), 1.0mg/mL, in MethanolPhenobarbital-ethyl-d5Phenobarbital-ethyl-d55,5-Diphenyl-d10-hydantoin5,5-Diphenyl-d10-hydantoinPilocarpine-d3 HydrochloridePilocarpine-d3 HydrochloridePioglitazone-d4Pioglitazone-d4Posaconazole-d4Posaconazole-d4Pravastatin-D3 Sodium SaltPravastatin-D3 Sodium SaltProbenecid-d14Probenecid-d14Quinidine-d3Quinidine-d3Quinine methoxy-D3Quinine methoxy-D3Quinine-d3Quinine-d3Raloxifene-d4Raloxifene-d4Repaglinide-ethyl-d5Repaglinide-ethyl-d5all-trans Retinoic Acid-d5all-trans Retinoic Acid-d5Rifampicin-d3Rifampicin-d3Ritonavir-d6Ritonavir-d6Ritonavir-13C3Ritonavir-13C3Rosiglitazone-d3Rosiglitazone-d3Rosuvastatin-d6, Sodium SaltRosuvastatin-d6, Sodium SaltSaquinavir-d9Saquinavir-d9rac Sertraline-d3 Hydrochloriderac Sertraline-d3 HydrochlorideSN-38-d3SN-38-d3Sulfamethazine-d4Sulfamethazine-d4Telmisartan-d3
Pack size
10 mg1 mg2.5 mg1 mg5 mg1 mg5 mg1 mL/ampule1 mL/ampule10 mg100 mg1 mg10 mg1 mg10 mg1 mL/ampule
1 mL/ampule
1 mL/ampule
1 mL/ampule
5 mg50 mg2.5 mg25 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg0.5 mg5 mg0.5 mg5 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg
Index description
Oxybutyninp-3-hydroxypaclitaxelp-3-hydroxypaclitaxelPaclitaxelPaclitaxelPaclitaxelPaclitaxelParacetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol (Acetaminophen)Paracetamol sulfate (Acetaminophen sulfate)Paracetamol sulfate (Acetaminophen sulfate)ParaxanthineParaxanthinePhencyclidine
Phencyclidine
Phenobarbital
Phenobarbital
PhenobarbitalPhenobarbitalPhenytoinPhenytoinPilocarpinePilocarpinePioglitazonePioglitazonePosaconazolePosaconazolePravastatinPravastatinProbenecidProbenecidQuinidineQuinidineQuinineQuinineQuinineQuinineRaloxifeneRaloxifeneRepaglinideRepaglinideRetinoic acidRetinoic acidRifampicinRifampicinRitonavirRitonavirRitonavirRitonavirRosiglitazoneRosiglitazoneRosuvastatinRosuvastatinSaquinavirSaquinavirSertralineSertralineSN-38 (Irinotecan metabolite)SN-38 (Irinotecan metabolite)SulfamethazineSulfamethazineTelmisartan
49www.lgcstandards.com
Labelled products onlyQuick reference catalogue listing for labelled compounds only.
LGC catalogue no.
TRC-T017002-10CERNMID644TRC-T155002TRC-T155002-50TRC-T425602TRC-T425602-5TRC-T542502TRC-T542502-10CERT-029
TRC-T712480TRC-T712480-10TRC-P319682
TRC-P319682-10
CERT-908TRC-T779202TRC-T779202-10TRC-T795616TRC-T795616-10TRC-T795617TRC-T795617-10TRC-T795618TRC-T795618-10TRC-V085002TRC-V085002-10TRC-V094752TRC-V094752-50TRC-V095752TRC-V095752-10TRC-V125002TRC-V125002-50TRC-H948392
TRC-H948392-10
Product description
Telmisartan-d319-d3-TestosteroneTestosterone-d3Testosterone-d3Thyroxine-13C6Thyroxine-13C6Topotecan-d6Topotecan-d6Tramadol-13C, D3 HCl, 100 µg/mL (as freebase), in MethanolTramadol-d6 HydrochlorideTramadol-d6 Hydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochloridetrans 2-(Phenyl-d5)-cyclopropylamineHydrochlorideTriazolam-D4, 100 µg/mL, in MethanolTrifluoperazine-d3 DihydrochlorideTrifluoperazine-d3 DihydrochlorideTrimethoprim-13C3Trimethoprim-13C3Trimethoprim-d9 (Major)Trimethoprim-d9 (Major)Trimethoprim-d3Trimethoprim-d3Valacyclovir-d4, HydrochlorideValacyclovir-d4, HydrochlorideValproic Acid-d6Valproic Acid-d6Valsartan-d3Valsartan-d3Verapamil-d6 HydrochlorideVerapamil-d6 Hydrochloridea-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)a-Hydroxy Metoprolol-d5 (Mixture ofDiastereomers)
Pack size
10 mg1 mg5 mg50 mg1 mg5 mg1 mg10 mg1 mL/ampule
1 mg10 mg1 mg
10 mg
1 mL/ampule1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg1 mg10 mg5 mg50 mg1 mg10 mg5 mg50 mg1 mg
10 mg
Index description
TelmisartanTestosteroneTestosteroneTestosteroneThyroxineThyroxineTopotecanTopotecanTramadol
TramadolTramadolTranylcypromine
Tranylcypromine
TriazolamTrifluoperazineTrifluoperazineTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimTrimethoprimValacyclovirValacyclovirValproic acidValproic acidValsartanValsartanVerapamilVerapamilα-hydroxymetoprolol
α-hydroxymetoprolol
50 www.lgcstandards.com
Description
Salmonella enterica subsp. enterica
Salmonella enterica subsp. enterica
Salmonella enterica subsp. enterica
Escherichia coli
ATCC® no.
29629TM
29630TM
29631TM
49979TM
Designation
TA 1535
TA 1537
TA 1538
NCIMB 11188[WP2 uvrA]
Common applications include
Mutation tests (Ames assay), Genotoxicity /Bacterial mutation assays
Mutation tests (Ames assay), Genotoxicity /Bacterial mutation assays
Mutation tests (Ames assay)
Genotoxicity / Bacterial mutation assays
ATCC® microbiology cultures
Bacteria
ATCCGenuine Cultures®: Direct from the Source
The ATCC Genuine Cultures emblem was
designed to help scientists identify authentic ATCC
microbial strains that come directly from ATCC.
ATCC Genuine Cultures are backed by meticulous
laboratory procedures and 80 years of experience
and represent ATCC’s high standards of quality for
microbial strains:
• Full characterisation of each strain to
establish identity;
• Utilisation of a seed stock system to minimise
subculturing;
• Careful preservation and storage protocols
to maintain the culture safely and effectively.
As always, a customer who purchases a genuine
ATCC culture from LGC Standards is receiving a
culture that is a direct, minimal-passage
descendant of the original material deposited with
ATCC and has been handled only by ATCC. These
products are backed by our warranty and covered
by our expert technical support.
Don’t take chances on the quality of your cultures.
Insist on products that meet ATCC’s high standards
of full characterisation and low passage number.
ATCC Genuine Cultures are only available in
Europe through LGC Standards.
®
All ATCC products are sold subject to a material transfer agreement. Appendix II details the complete document.The full ATCC microbiology collection can be viewed at www.lgcstandards-atcc.org.
51www.lgcstandards.com
Description
Mus musculus (mouse); areolar fibroblast
Homo sapiens (human); cervicaladenocarcinoma
Canis familiaris; kidney
Cricetulus griseus (hamster, Chinese); ovary
Cercopithecus aethiops (african greenmonkey); kidney
Cricetulus griseus (hamster, Chinese); lung
Homo sapiens (human); neuroblastoma
Homo sapiens (human); rhabdomyosarcoma
Mus musculus (mouse); embryo fibroblast
Homo sapiens (human); lung carcinoma
Homo sapiens (human); lung fibroblast
Homo sapiens (human); promyelocyticleukemia
Homo sapiens (human); leukemia (CML)
Homo sapiens (human); colorectal carcinoma
Homo sapiens (human); prostateadenocarcinoma
Homo sapiens (human); pancreatic carcinoma
Homo sapiens (human); breast carcinoma
Homo sapiens (human); epidermoid carcinoma
ATCC® no.
CCL-1™
CCL-2™
CCL-34™
CCL-61™
CCL-70™
CCL-93™
CCL-127™
CCL-136™
CCL-163™
CCL-185™
CCL-186™
CCL-240™
CCL-243™
CL-187™
CRL-1435™
CRL-1469™
CRL-1500™
CRL-1555™
Designation
NCTC clone 929
HeLa
MDCK (NBL-2)
CHO-K1
CV-1
V79-4
IMR-32
RD
BALB/3T3 clone A31
A549
IMR-90
HL-60
K-562
LS 180
PC-3
PANC-1
ZR-75-1
A-431
Common applications include
Agar overlay, MEM elution
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Cytosensor microphysiometer bioassay, P-gpinhibition with calcein AM substrate
Transactivation assays (hormone-sensitivetranscription of reporter genes), Genotoxicity /Mammalial cell assays (ICH Guideline), Uptaketransporter assays, micronucleus assay, hERGin vitro assay
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Cytotoxicity
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cell transformation test, Phototoxicity
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability, Dye transportassays (Calcein and Hoechst 33342 assays)
Dye transport assays (Calcein and Hoechst33342 assays)
Pgp induction / inhibition assay
Transactivation assays (hormone-sensitivetranscription of reporter genes), Cytotoxicity:Apoptosis, Cellular anabolism, Cellularmetabolism, Cellular respiration (ATP/ADP),Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cell lines
ATCC® cell biology cultures
The ATCC Cell Biology Collection is the most comprehensive and diverse of its kind in the world, consisting of over
3,400 cell lines from over 80 different species. It holds over 950 cancer cell lines, 1,000 hybridomas and several special
collections including stem cells and primary cells. The full collection can be found at www.lgcstandards-atcc.org.
®
All ATCC products are sold subject to a material transfer agreement. Appendix II details the complete document.The full ATCC collection can be viewed at www.lgcstandards-atcc.org.
52 www.lgcstandards.com
DescriptionATCC® no. Designation Common applications include
ATCC® cell biology cultures
Cell lines
CRL-1573™
CRL-1593.2™
CRL-1650™
CRL-1658™
CRL-1721™
CRL-1722™
CRL-1730™
CRL-1740™
CRL-1934™
CRL-1935™
CRL-1990™
CRL-2026™
CRL-2062™
CRL-2064™
CRL-2102™
CRL-2103™
CRL-2142™
CRL-2266™
CRL-2873™
CRL-8015™
Homo sapiens (human); embryonic kidney
Homo sapiens (human); histiocytic lymphoma
Cercopithecus aethiops (african greenmonkey); kidney
Mus musculus (mouse); embryonic fibroblast
Rattus norvegicus (rat); pheochromocytoma
Mus musculus (mouse); lymphoma
Homo sapiens (human); vascularendothelium
Homo sapiens (human); prostate carcinoma
Mus musculus (mouse); stem cell
Cricetulus griseus (hamster, Chinese); lung
Homo sapiens (human); acute T cellleukemia
Mus musculus (mouse); liver hepatoma
Homo sapiens (human); human lung, smallcell carcinoma (licence may be required)
Homo sapiens (human); lung carcinoma
Homo sapiens (human); colonadenocarcinoma
Homo sapiens (human); normal skinfibroblast
Homo sapiens (human); neuroblastoma
Homo sapiens (human) neuroblastoma
Homo sapiens (human); vascularendothelium
Homo sapiens (human); lymphoblast
293 [HEK-293]
U-937
COS-1
NIH/3T3
PC-12
L5178-R (LY-R)
HUV-EC-C
LNCaP clone FGC
ES-D3 [D3]
CHL/IU [CHL-11]
J45.01
Hepa-1c1c7
DMS 53
DMS 153
C2BBe1 [clone ofCaco-2 (HTB-37™)]
CCD-1086Sk
SK-N-F1
SH-SY5Y
HUVEC-CS
TK6
Transactivation assays (hormone-sensitivetranscription of reporter genes), hERG in vitroassay
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Phototoxicity assay
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Cell mutation tests, In vitro mammalian cellmicronucleus test, Genotoxicity / Mammaliancell assays (ICH guideline), Mammalian genemutation test (MLA)
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Reproductive toxicity (ES)
Chromosome aberrations assay
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
In vitro absorption, Active efflux determination,P-gp substrate determination, P-gp inhibitiondetermination
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytokinesis-blocked micronucleus assay,in vitro aneuploidy, Genotoxicity / Mammaliancell assays (ICH guideline)
®
All ATCC products are sold subject to a material transfer agreement. Appendix II details the complete document.The full ATCC collection can be viewed at www.lgcstandards-atcc.org.
53www.lgcstandards.com
DescriptionATCC® no. Designation Common applications include
ATCC® cell biology cultures
Cell lines
CRL-11609™
HB-8065™
HTB-11™
HTB-22™
HTB-26™
HTB-30™
HTB-37™
HTB-38™
HTB-85™
HTB-112™
HTB-133™
HTB-148™
HTB-153™
PCS-100-010
TIB-202™
Homo sapiens (human); prostate epithelium
Homo sapiens (human); hepatocellularcarcinoma
Homo sapiens (human); neuroblastoma
Homo sapiens (human); breastadenocarcinoma
Homo sapiens (human); breastadenocarcinoma
Homo sapiens (human); breastadenocarcinoma
Homo sapiens (human); colonadenocarcinoma
Homo sapiens (human); colonadenocarcinoma
Homo sapiens (human); osteosarcoma
Homo sapiens (human); uterusadenocarcinoma
Homo sapiens (human); endometrialcarcinoma
Homo sapiens (human); neuroglioma
Homo sapiens (human); rhabdomyosarcoma
Homo sapiens (human); primary umbilicalvein endothelial cells; normal
Homo sapiens (human); acute monocyticleukemia
RWPE-1
Hep G2
SK-N-SH
MCF7
MDA-MB-231
SK-BR-3
Caco-2
HT-29
Saos-2
HEC-1-A
T-47D
H4
Hs 729 [Hs 729T]
HUVEC
THP-1
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity, Transactivation assays(hormone-sensitive transcription of reportergenes), Phospholipidosisa
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Induction of hormone-responsive mammaliancell proliferation, Transactivation assays(hormone-sensitive transcription of reportergenes), Cytotoxicity: Apoptosis, Cellularanabolism, Cellular metabolism, Cellularrespiration (ATP/ADP), Proliferation, Viability
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
In vitro absorption, Active efflux determination,P-gp substrate determination, P-gp inhibitiondetermination
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Transactivation assays (hormone-sensitivetranscription of reporter genes)
Transactivation assays (hormone-sensitivetranscription of reporter genes), Cytotoxicity:Apoptosis, Cellular anabolism, Cellularmetabolism, Cellular respiration (ATP/ADP),Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
Cytotoxicity: Apoptosis, Cellular anabolism,Cellular metabolism, Cellular respiration(ATP/ADP), Proliferation, Viability
®
All ATCC products are sold subject to a material transfer agreement. Appendix II details the complete document.The full ATCC collection can be viewed at www.lgcstandards-atcc.org.
Culture reagent descriptionCulture reagentcatalogue no.
Vascular Cell Basal Medium; 500mlEndothelial Cell Growth Kit-BBEEndothelial Cell Growth Kit-VEGF
Vascular Cell Basal Medium; 500mlEndothelial Cell Growth Kit-BBEEndothelial Cell Growth Kit-VEGF
Vascular Cell Basal Medium; 500mlVascular Smooth Muscle Cell Growth Kit
Dermal Cell Basal Medium; 485 mlKeratinocyte Growth Kit
Dermal Cell Basal Medium; 485 mlKeratinocyte Growth Kit
Dermal Cell Basal Medium; 485 mlMelanocyte Growth Kit
Fibroblast Basal MediumFibroblast Growth Kit-Serum-freeFibroblast Growth Kit-Low serum
Fibroblast Basal MediumFibroblast Growth Kit-Serum-freeFibroblast Growth Kit-Low serum
Fibroblast Basal MediumFibroblast Growth Kit-Serum-freeFibroblast Growth Kit-Low serum
Airway Epithelial Cell Basal MediumBronchial Epithelial Cell Growth Kit
Airway Epithelial Cell Basal MediumSmall Airway Epithelial Cell Growth Kit
Renal Epithelial Cell Basal MediumRenal Epithelial Cell Growth Kit
Renal Epithelial Cell Basal MediumRenal Epithelial Cell Growth Kit
Renal Epithelial Cell Basal MediumRenal Epithelial Cell Growth Kit
Phenol Red
Penicillin-Streptomycin-Amphotericin B Solution
Trypsin/EDTA Solution for Primary Cells
Trypsin Neutralizing Solution
Gentamicin - Amphotericin B Solution
0.1% Gelatin Solution
Dulbecco’s Phosphate Buffered Saline(D-PBS)
PCS-100-030PCS-100-040PCS-100-041
PCS-100-030PCS-100-040PCS-100-041
PCS-100-030PCS-100-042
PCS-200-030PCS-200-040
PCS-200-030PCS-200-040
PCS-200-030PCS-200-041
PCS-201-030PCS-201-040PCS-201-041
PCS-201-030PCS-201-040PCS-201-041
PCS-201-030PCS-201-040PCS-201-041
PCS-300-030PCS-300-040
PCS-300-030PCS-301-040
PCS-400-030PCS-400-040
PCS-400-030PCS-400-040
PCS-400-030PCS-400-040
PCS-999-001
PCS-999-002
PCS-999-003
PCS-999-004
PCS-999-025
PCS-999-027
30-2200
54 www.lgcstandards.com
DescriptionATCC® no.
Primary cells, media and reagents
Primary cell cultures more closely mimic the physiological state of cells in vivo and generate more relevant data. Traditional
attention to quality, research and science makes ATCC your most reliable source for primary cells. Each lot of cells is
performance tested for viability and growth potential; sample purity and normal morphology are also assured.
Primary cell line
PCS-100-010
PCS-100-011
PCS-100-012
PCS-200-010
PCS-200-011
PCS-200-012
PCS-201-010
PCS-201-011
PCS-201-012
PCS-300-010
PCS-301-010
PCS-400-010
PCS-400-011
PCS-400-012
Primary Umbilical Vein Endothelial Cells;Normal, Human
Primary Aortic Endothelial Cells; Normal,Human
Primary Aortic Smooth Muscle Cells; Normal,Human
Primary Epidermal Keratinocytes; Normal,Human, Neonatal
Primary Epidermal Keratinocytes; Normal,Human, Adult
Primary Epidermal Melanocytes; Normal,Human, Neonatal
Dermal Fibroblasts; Normal, Human, Neonatal
Dermal Fibroblasts; Normal, Human, Neonatal,Mitomycin-C treated
Dermal Fibroblasts; Normal, Human, Adult
Primary Bronchial/Tracheal Epithelial Cells;Normal, Human
Primary Small Airway Epithelial Cells;Normal, Human
Primary Renal Proximal Tubule EpithelialCells; Normal, Human
Primary Renal Cortical Epithelial Cells;Normal, Human
Primary Renal Mixed Epithelial Cells; Normal,Human
Recommended culture reagents
Culture reagent descriptionCatalogue no.
All ATCC products are sold subject to a material transferagreement. Appendix II details the complete document.
Additional primary cells are being added all the time.Refer to the ATCC primary cell page:www.lgcstandards-atcc.org/PrimaryCells/tabid/1516/Default.aspx
Additional culture reagents optimised for culturing primary cells
®
55www.lgcstandards.com
DescriptionSpecies Quantity Product code
Fresh hepatocytes from LGC Standards
Rat
Mouse
Rabbit
Human
Other species
Rat Hepatocytes in SuspensionSuspension (5 million cells) - Minimum order 2 platesSuspension, Pre-induced with 3-MethylcolanthreneSuspension, Pre-induced with Sodium PhenobarbitalIn vivo Induction Charge
Rat Hepatocytes, Pre-platedPre-plated on 35mm dish - Min 10 platesPre-plated on 60mm dish - Min 10 platesPre-plated on 100mm dish - Min 5 platesPre-plated on 6 well platePre-plated on 12 well platePre-plated on 24 well platePre-plated on 48 well platePre-plated on 96 well plate
Rat Hepatocytes Induced(3-Methycholanthrene), Pre-plated on CollagenInduced, Pre-plated on Collagen Coated 6-well PlatesInduced, Pre-plated on Collagen Coated 12-well PlatesInduced, Pre-plated on Collagen Coated 24-well PlatesInduced, Pre-plated on Collagen Coated 48-well PlatesInduced, Pre-plated on Collagen Coated 96-well PlatesIn vivo Induction Charge
Rat Hepatocytes Induced(Sodium Phenobarbital), Pre-plated on CollagenInduced, Pre-plated on Collagen Coated 6-well PlatesInduced, Pre-plated on Collagen Coated 12-well PlatesInduced, Pre-plated on Collagen Coated 24-well PlatesInduced, Pre-plated on Collagen Coated 48-well PlatesInduced, Pre-plated on Collagen Coated 96-well PlatesIn vivo Induction Charge
Mouse Hepatocytes in SuspensionSuspension (5 million cells) - Minimum order 2 plates
Mouse Hepatocytes, Pre-platedPre-plated on 6 Well PlatePre-plated on 12 Well PlatePre-plated on 24 Well PlatePre-plated on 48 Well PlatePre-plated on 96 Well Plate
Rabbit Hepatocytes, SuspensionRabbit - Suspension - 10 million cells
Rabbit Hepatocytes, Pre-platedPre-plated on 6 Well PlatePre-plated on 12 Well PlatePre-plated on 24 Well PlatePre-plated on 48 Well PlatePre-plated on 96 Well Plate
Available on request. Please contact your localLGC Standards office for further information anddelivery schedules.
Available on request.
2 plate10 plates2 plates
10 plates10 plates5 plates6 well plate12 well plate24 well plate24 well plate96 well plate
6 well plate12 well plate24 well plate48 well plate96 well plate
6 well plate12 well plate24 well plate48 well plate96 well plate
10 plate
6 well plate12 well plate24 well plate48 well plate96 well plate
1 plate
6 well plate12 well plate24 well plate24 well plate96 well plate
ABC-SUSPRHABC-SUSP-RHMCABC-SUSP-RHPBABC-INDN-CHGE
ABC-35PCC-RHABC-60PCC-RHABC-100PCC-RHABC-06WPCCRHABC-12WPCCRHABC-24WPCCRHABC-48WPCCRHABC-96WPCCRH
ABC-6WPCC-RHMCABC-12WPCC-RHMCABC-24WPCC-RHMCABC-48WPCC-RHMCABC-96WPCC-RHMCABC-INDN-CHGE
ABC- 6WPCC-RHPBABC-12WPCC-RHPBABC-24WPCC-RHPBABC-48WPCC-RHPBABC-96WPCC-RHPBABC-INDN-CHGE
ABC-SUSPMH
ABC-06WPCCMHABC-12WPCCMHABC-24WPCCMHABC-48WPCCMHABC-96WPCCMH
ABC-SUSPZH
ABC-06WPCCZHABC-12WPCCZHABC-24WPCCZHABC-48WPCCZHABC-96WPCCZH
Ultra-pure solvents fromLGC Standards
Ultra HPLC (UHPLC) requires solvents of superiorquality in order to achieve the optimum performanceof the instrument and columns.
UHPLC can provide very significant increases inresolution, speed, and sensitivity, compared toconventional HPLC. To ensure these benefits arerealised, and so gain the full benefits of investment insuch sophisticated technology, solvents of the highestpurity are required.
The range of Optigrade® solvents from LGC Standards hasbeen designed to support high resolution and sensitivity forUHPLC and MS by tightly controlling the trace metal impurities,organic impurities and particle levels. Also available are selectedbuffers for mobile phase preparation, and several blends of waterand acetonitrile with formic acid, acetic acid and trifluoroacetic acid.
LGC Standards Optigrade® solvents combine:• The highest specification for UV• Low gradient shift• Minimal peak impurities• Lowest ionic background for MS detection
Our Optigrade® solvents for UHPLC and MS:• Are micro filtered at 0.1 µm• Have a residue of max 1ppm following evaporation• Are packed under inert gas for improved shelf life• Provided with MSDS and certificate of analysis
57www.lgcstandards.com
Introduction
Optigrade® – High purity solvents for HPLC
High performance liquid chromatography is now
an essential analytical tool especially in the areas
of research and development, pharmaceutical
quality control and analysis in the food and
environmental sectors. This technique demands
the highest quality solvents to allow reproducible
separations. The basic requirements include a
high UV-transmission factor, low particle levels,
slight acidity and alkalinity coupled with low levels
of water and other non-volatile components. In
addition there must be consistency between
batches.
Solvents for LC/MS
The presence of alkali and alkaline earth metals
in the mobile phase when using LC/MS can make
the interpretation of the mass spectrum very
difficult. LGC Standards offers solvents designed
for this technique with extremely low levels of
these metals at 0.1 ppm and less.
Solvents for Ultra HPLC (UHPLC)
ULTRA HPLC (UHPLC) requires solvents of
superior quality. A new range of high purity
Optigrade® solvents from LGC Standards has
been designed to allow high resolution and
sensitivity. Such Ultra HPLC solvents combine
the highest specification for: UV, low gradient
shift, minimal peak impurities and lowest ionic
background for MS detection. All Ultra HPLC
solvents are micro filtered at 0.1 µm, have a
residue following evaporation of max 1 ppm
and are packed under inert gas for improved
shelf life. Also available are selected buffers for
mobile phase preparation and several blends of
water and acetonitrile with formic acid, acetic
acid and trifluoroacetic acid.
Reagents / sorbents
Code Product Unit
SC-4592-A005 ICN-Aluminia A - Super I (acid) 500 g(50 - 200 µm)
SC-4568-A005 ICN-Alumina B - Super I (basic) 500 g(50 - 200 µm)
SC-4181-B005 FLORISIL® (Standard), 60 - 100 mesh 500 g(150 - 250 µm)
SC-4181-S010 FLORISIL® (Standard), 60 - 100 mesh 10 kg(150 - 250 µm)
SC-9982-B010 Silica gel 60 (63 - 200 µm) 1 kg
SC-9950-B005 Sodium sulfate anhydrous, 500 gfor analysis (ACS), powder
SC-9950-B025 Sodium sulfate anhydrous, 2.5 kgfor analysis (ACS), powder
SC-8024-B005 Sodium sulfate anhydrous, 500 gfor analysis (ACS), in granular form
SC-8024-B025 Sodium sulfate anhydrous, 2.5 kgfor analysis (ACS), in granular form
Ion pair reagents
Code Product Unit
SC-5330-F025 1-Butanesulfonic acid sodium salt for HPLC 25 g
SC-5330-F100 1-Butanesulfonic acid sodium salt for HPLC 100 g
SC-5650-F025 1-Decanesulfonic acid sodium salt for HPLC 25 g
SC-5650-F100 1-Decanesulfonic acid sodium salt for HPLC 100 g
SC-5430-F025 1-Dodecanesulfonic acid sodium salt for HPLC 25 g
SC-5430-F100 1-Dodecanesulfonic acid sodium salt for HPLC 100 g
SC-5230-F025 1-Heptanesulfonic acid sodium salt for HPLC 25 g
SC-5230-F100 1-Heptanesulfonic acid sodium salt for HPLC 100 g
SC-5550-F025 1-Hexanesulfonic acid sodium salt for HPLC 25 g
SC-5550-F100 1-Hexanesulfonic acid sodium salt for HPLC 100 g
SC-5150-F025 1-Octanesulphonic acid sodium salt for HPLC 25 g
SC-5150-F100 1-Octanesulphonic acid sodium salt for HPLC 100 g
SC-5730-F025 1-Pentanesulfonic acid sodium salt for HPLC 25 g
SC-5730-F100 1-Pentanesulfonic acid sodium salt for HPLC 100 g
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59www.lgcstandards.com
LC-MS additives
Code Product Unit
SO-9685-B001 Ammonium acetate ULC-MS Optigrade® 100 g
CAS number 631-61-8
Assay (GC, on anhydrous basis) 99 % min.
Water (KF) 0.1 % max.
Filter test (1M in water) Passes test
pH (1M in water) 6.0-7.5
Transmissionat 260 nm (1M in water) 96 %at 280 nm (1M in water) 98 %
Chloride (Cl) 0.0005% max.Sulfate (SO4) 001% max.
Al 1 ppm max.Ca 5 ppm max.Fe 1 ppm max.K 5 ppm max.Mg 1 ppm max.Na 5 ppm max.
SO-9679-B001 Formic acid ULC-MS Optigrade® 100 mL
UN 1779
CAS number 64-18-6
Assay (T, on anhydrous basis) 99 % min.
Water (KF) 1 % max.
Residue after evaporation 0.001 % w/w max.
Color (APHA) 10 max.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.005 AU max.HPLC gradient at 254 nm - Drift 0.02 AU max.
Transmissionat 260 nm 15 % min.at 270 nm 83 % min.at 280 nm 90 % min.at 300 nm 97 % min.at 320 nm 98 % min.
SO-9668-B001 Trifluoroacetic acid ULC-MS Optigrade® 100 mL
UN 2699
CAS number 76-05-1
Assay (T) 99.95 % min.
Water (KF) 0.02 % max.
Residue after evaporation 0.001 % w/w max.
Color (APHA) 10 max.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - Drift 0.010 AU max.
Fluorescence at 254 nm (25%, as quinine) 1 ppb max.Fluorescence at 365 nm (25%, as quinine) 1 ppb max.
Transmissionat 260 nm 10 % min.at 270 nm 79 % min.at 280 nm 93 % min.at 300 nm 95 % min.at 320 nm 96 % min.
High purity solvents and acids
Code Product Unit
Acetone
SO-2435-B010 Acetone HPLC Optigrade® 1 L
SO-2435-B010 Acetone HPLC Optigrade® 2.5 L
SO-2435-B010 Acetone HPLC Optigrade® 4 L
UN 1090
CAS number 67-64-1
C3H6O
Assay 99.5 % min.Water 0.5 % max.Non-volatile matter 0.0005 % max.
Filtered through 0.2 µm
1 L = 0.792 kg (at 20°C)
Optical absorbance Wavelength1.0 max. 330 nm0.1 340 nm0.05 350 nm0.01 370 nm
Acetonitrile
SO-2856-B010 Acetonitrile HPLC Optigrade® 1 L
SO-2856-B025 Acetonitrile HPLC Optigrade® 2.5 L
SO-2856-B040 Acetonitrile HPLC Optigrade® 4 L
UN 1648
CAS number 75-05-8
C2H3N
Assay 99.8 % min.Water 0.02 % max.Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.783 kg (at 20°C)
Optical absorbance Wavelength1.0 max. 190 nm0.1 200 nm0.05 210 nm0.02 220 nm0.01 230 nm0.005 235 nm
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High purity solvents and acids
Code Product Unit
SO-9340-B010 Acetonitrile for LC-MS Optigrade® 1 L
SO-9340-B025 Acetonitrile for LC-MS Optigrade® 2.5 L
UN 1648
CAS number 75-05-8
C2H3N
Assay 99.8 % min.
Water 0.02 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.783 kg (at 20°C)
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Transmissionat 195 nm 78 % min.at 200 nm 95 % min.at 220 nm 98 % min.at 240 nm 99 % min.
SO-9640-B010 Acetonitrile ULC-MS Optigrade® 1 L
UN 1648
CAS number 75-05-8
C2H3N
Assay (GC, on anhydrous basis) 99.97 % min.
Water (KF) 0.01 % max.
Residue after evaporation 0.0001 % w/w max.
Acidity (as acetic acid) 0.001 % max.
Alkalinity (as ammonia) 0.0001 % max.
Color (APHA) 5 max.
Gradient specificationHPLC gradient at 210 nm - Drift 0.006 AU max.HPLC gradient at 254 nm - Drift 0.002 AU max.HPLC gradient at 210 nm - H. Peak 0.001 AU max.HPLC gradient at 254 nm - H. Peak 0.0003 AU max.
Fluorescence at 254 nm (as quinine) 0.3 ppb max.Fluorescence at 365 nm (as quinine) 0.3 ppb max.
1 L = 0.792 kg (at 20°C)
Transmissionat 191 nm 30 % min.at 195 nm 85 % min.at 200 nm 97 % min.at 215 nm 98 % min.at >230 nm 99 % min.
Al 20 ppb max.Ca 50 ppb max.Fe 20 ppb max.K 50 ppb max.Mg 20 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
High purity solvents and acids
Code Product Unit
SO-4680-B025 Acetonitrile 0.1 % formic acid ULC-MS Optigrade® 2.5 L
UN 1648
CAS number 75-05-8
C2H3N
Assay 0.095-0.105 %
Water (KF) 0.02 % max.
Purity of ACN (GC) 99.97 % min.
Purity of formic acid 99.0% min.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
Transmissionat 210 nm 5 % min.at 230 nm 15 % min.at 254 nm 90 % min.
Al 30 ppb max.Ca 100 ppb min.Fe 50 ppb min.K 100 ppb min.Mg 30 ppb min.Na 100 ppb min.
Microfiltered through 0.1 µm/bottled under inert gas.
SO-4680-B025 Acetonitrile 0.1 % acetic acid ULC-MS Optigrade® 2.5 L
UN 1648
CAS number 75-05-8
C2H3N
Assay 0.095-0.105 %
Purity of ACN (GC) 99.97 % min.
Purity of acetic acid (GC) 99.9 % min.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - Drift 0.010 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
Transmissionat 210 nm 20 % min.at 230 nm 50 % min.at 254 nm 98 % min.
Al 30 ppb max.Ca 100 ppb max.Fe 50 ppb max.K 100 ppb max.Mg 30 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
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High purity solvents and acids
Code Product Unit
SO-4692-B025 Acetonitrile 0.1 % trifluoroacetic acid ULC-MS Optigrade® 2.5 L
UN 1648
CAS number 75-05-8
C2H3N
Assay 0.095-0.105 %
Water (KF) 0.02 % max.
Purity of ACN (GC) 99.97 % min.
Purity of trifluoroacetic acid 99.95 % min.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.0002 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
Transmissionat 210 nm 20 % min.at 230 nm 50 % min.at 254 nm 90 % min.
Al 30 ppb max.Ca 100 ppb max.Fe 50 ppb max.K 100 ppb max.Mg 30 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
Chloroform
SO-4443-B010 Chloroform HPLC Optigrade® (alcohol-free. stab. with amylene) 1 L
SO-4443-B010 Chloroform HPLC Optigrade® (alcohol-free. stab. with amylene) 2.5 L
SO-4443-B010 Chloroform HPLC Optigrade® (alcohol-free. stab. with amylene) 4 L
UN 1888
CAS number 67-66-3
CHCl3
Assay 99.9 % min.
Water 0.03 % max.
Non-volatile matter 0.0002 % max.
Filtered through 0.2 µm
1 L = 1.475 kg (at 20°C)
stabilised with 50 - 200 ppm amylene
Optical absorbance Wavelength1.0 max 245 nm0.15 255 nm0.05 260 nm0.02 270 nm0.01 290 nm
High purity solvents and acids
Code Product Unit
Cyclohexane
SO-9052-B010 Cyclohexane HPLC Optigrade® 1 L
SO-9052-B025 Cyclohexane HPLC Optigrade® 2.5 L
UN 1145
CAS number 110-82-7
C6H12
Assay 99.5 % min.
Water 0.02 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.779 kg (at 20°C)
Optical absorbance Wavelength0.700 max 210 nm0.320 220 nm0.125 230 nm0.025 245 nm0.005 260 nm
Cyclopentane
SO-6157-B010 Cyclopentane HPLC Optigrade® 1 L
UN 1146
CAS number 287-92-3
C5H10
Assay 75 % min.
Water 0.005 % max.
Non-volatile matter 0.0001 % max.
Filtered through 0.2 µm
1 L = 0.751 kg (at 20°C)
Optical absorbance Wavelength1.0 max 200 nm0.3 215 nm0.02 225 nm0.005 300 nm
Dichloromethane
SO-4879-B010 Dichloromethane HPLC Optigrade® (stab. with amylene) 1 L
SO-4879-B025 Dichloromethane HPLC Optigrade® (stab. with amylene) 2.5 L
SO-4879-B040 Dichloromethane HPLC Optigrade® (stab. with amylene) 4 L
UN 1593
CAS number 75-09-2
CH2Cl2
Assay 99.8 % min.
Water 0.02 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 1.335 kg (at 20°C)
stabilised with 60 - 100 ppm amylene
Optical absorbance Wavelength1.0 max 233 nm0.15 240 nm0.01 254 nm0.005 280 nm
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High purity solvents and acids
Code Product Unit
Diethyl ether
SO-9012-B010 Diethyl ether HPLC Optigrade® (stab. with ethanol) 1 L
SO-9012-B025 Diethyl ether HPLC Optigrade® (stab. with ethanol) 2.5 L
UN 1155
CAS number 60-29-7
C4H10O
Assay 99.0 % min.
Water 0.01 % max.
Non-volatile matter 0.0005 % max.
Peroxide 5 ppm max.
Filtered through 0.2 µm
1 L = 0.713 kg (at 20°C)
stabilised with 2 % ethanol
Optical absorbance Wavelength1.0 max 215 nm0.3 230 nm0.08 254 nm0.04 270 nm0.02 280 nm0.005 300 nm
SO-2854-B010 Diethyl ether HPLC Optigrade® (not stabilised) 1 L
UN 1155
CAS number 60-29-7
C4H10O
Assay 99.0 % min.
Water 0.01 % max.
Non-volatile matter 0.0005 % max.
Peroxide 5 ppm max.
Filtered through 0.2 µm
1 L = 0.713 kg (at 20°C)
not stabilised
Optical absorbance Wavelength1.0 max 215 nm0.08 254 nm0.02 280 nm
High purity solvents and acids
Code Product Unit
N.N-Dimethylacetamide
SO-5407-B025 N.N-Dimethylacetamide HPLC Optigrade® 2.5 L
SO-5407-B040 N.N-Dimethylacetamide HPLC Optigrade® 4 L
CAS number 127-19-5
C4H9NO
Assay 99.0 % min.
Water 0.03 % max.
Non-volatile matter 0.0006 % max.
Filtered through 0.2 µm
1 L = 0.937 kg (at 20°C)
Optical absorbance Wavelength1.0 max 270 nm0.3 280 nm0.15 290 nm0.05 310 nm0.01 360 nm
N.N-Dimethylformamide
SO-5356-B025 N.N-Dimethylformamide HPLC Optigrade® 2.5 L
SO-5356-B040 N.N-Dimethylformamide HPLC Optigrade® 4 L
UN 2265
CAS number 68-12-2
C3H7NO
Assay 99.7 % min.
Water 0.05 % max.
Non-volatile matter 0.0006 % max.
Filtered through 0.2 µm
1 L = 0.951 kg (at 20°C)
Optical absorbance Wavelength1.0 max 270 nm0.3 275 nm0.1 295 nm0.05 310 nm0.01 340 nm
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High purity solvents and acids
Code Product Unit
1.4-Dioxan
SO-9002-B010 1.4-Dioxan HPLC Optigrade® (not stabilised) 1 L
SO-9002-B025 1.4-Dioxan HPLC Optigrade® (not stabilised) 2.5 L
UN 1165
CAS number 123-91-1
C4H8O2
Assay 99.5 % min.
Water 0.05 % max.
Non-volatile matter 0.0002 % max.
Filtered through 0.2 µm
1 L = 1.034 kg (at 20°C)
not stabilised
Optical absorbance Wavelength0.5 max 225 nm0.25 250 nm0.1 270 nm0.05 280 nm0.01 295 nm
Ethanol
SO-9063-B010 Ethanol HPLC Optigrade® 1 L
SO-9063-B025 Ethanol HPLC Optigrade® 2.5 L
UN 1170
CAS number 64-17-5
C2H5OH
Assay 99.7 % min.
Water 0.1 % max.
Non-volatile matter 0.0004 % max.
Filtered through 0.2 µm
1 L = 0.789 kg (at 20°C)
Optical absorbance Wavelength0.7 max 210 nm0.1 240 nm0.01 260 nm
2-Ethoxyethanol
SO-2925-B025 2-Ethoxyethanol HPLC Optigrade® 2.5 L
UN 1171
CAS number 110-80-5
C4H10O2
Assay 99.5 % min.
Water 0.08 % max.
Non-volatile matter 0.0002 % max.
Filtered through 0.2 µm
1 L = 0.932 kg (at 20°C)
Optical absorbance Wavelength1.0 max 222 nm0.75 225 nm0.25 250 nm0.01 300 nm
High purity solvents and acids
Code Product Unit
Ethyl acetate
SO-3442-B010 Ethyl acetate HPLC Optigrade® 1 L
SO-3442-B025 Ethyl acetate HPLC Optigrade® 2.5 L
SO-3442-B040 Ethyl acetate HPLC Optigrade® 4 L
UN 1173
CAS number 141-78-6
CH3COOC2H5
Assay 99.5 % min.
Water 0.05 % max.
Non-volatile matter 0.0005 % max.
Filtered through 0.2 µm
1 L = 0.897 kg (at 20°C)
Optical absorbance Wavelength1.0 max 255 nm0.1 260 nm0.05 280 nm0.01 300 nm
SO-9345-B010 Ethyl acetate for LC-MS Optigrade® 1 L
SO-9345-B025 Ethyl acetate for LC-MS Optigrade® 2.5 L
UN 1173
CAS number 141-78-6
CH3COOC2H5
Assay 99.5 % min.
Water 0.05 % max.
Non-volatile matter 0.0005 % max.
Filtered through 0.2 µm
1 L = 0.897 kg (at 20°C)
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Transmissionat 260 nm 70 % min.at 280 nm 99 % min.
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High purity solvents and acids
Code Product Unit
n-Heptane
SO-5139-B010 n-Heptane HPLC Optigrade® 1 L
SO-5139-B025 n-Heptane HPLC Optigrade® 2.5 L
SO-5139-B040 n-Heptane HPLC Optigrade® 4 L
UN 1206
CAS number 142-82-5
C7H16
Assay 95.0 % min.
Water 0.02 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.685 kg (at 20°C)
Optical absorbance Wavelength1.0 max 197 nm0.4 210 nm0.1 225 nm0.01 254 nm
n-Hexane
SO-5167-B010 n-Hexane HPLC Optigrade® 1 L
SO-5167-B025 n-Hexane HPLC Optigrade® 2.5 L
SO-5167-B040 n-Hexane HPLC Optigrade® 4 L
UN 1208
CAS number 110-54-3
C6H14
Assay (of C6-isomers) 99.8 % min.
Water 0.1 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.659 kg (at 20°C)
Optical absorbance Wavelength1.0 max 195 nm0.25 210 nm0.1 220 nm0.01 254 nm0.005 280 nm0.005 350 nm
Iso-Hexane
SO-9043-B025 Iso-Hexane HPLC Optigrade® 2.5 L
UN 1208
CAS number 107-83-5
C6H14
Assay (of C6-isomers) 95.0 % min.
Water 0.01 % max.
Non-volatile matter 0.0002 % max.
1 L = 0.653 kg (at 20°C)
Optical absorbance Wavelength1.0 max 195 nm0.25 210 nm0.2 217 nm0.125 220 nm0.02 245 nm
High purity solvents and acids
Code Product Unit
MethanolSO-3041-B010 Methanol HPLC Optigrade® 1 L
SO-3041-B025 Methanol HPLC Optigrade® 2.5 L
SO-3041-B040 Methanol HPLC Optigrade® 4 L
UN 1230
CAS number 67-56-1
CH3OH
Assay 99.9 % min.
Water 0.05 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.792 kg (at 20°C)
Optical absorbance Wavelength1.0 max 205 nm0.25 220 nm0.05 240 nm0.015 254 nm0.005 280 nm0.005 350 nm
This solvent in glass bottles fulfills the specifications according to chapter 4 of the European Pharmacopoeia.
SO-9658-B010 Methanol ULC-MS Optigrade® 1 L
UN 1230
CAS number 67-56-1
CH3OH
Assay (GC, on anhydrous basis) 99.98 % min.
Water (KF) 0.03 % max.
Residue after evaporation 0.0001 %w/w max.
Acidity (as acetic acid) 0.002 % max.
Alkalinity (as ammonia) 0.0001 % max.
Color (APHA) 5 max.
Gradient specificationHPLC gradient at 220 nm - Drift 0.01 AU max.HPLC gradient at 235 nm - Drift 0.005 AU max.HPLC gradient at 220 nm - H. Peak 0.004 AU max.HPLC gradient at 235 nm - H. Peak 0.002 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.3 ppb max.
1 L = 0.783 kg (at 20°C)
Transmissionat 210 nm 40 % min.at 220 nm 65 % min.at 230 nm 80 % min.at 260 nm 98 % min.
Al 20 ppb max.Ca 100 ppb max.Fe 20 ppb max.K 50 ppb max.Mg 20 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
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High purity solvents and acids
Code Product Unit
SO-9356-B010 Methanol for LC-MS Optigrade® 1 L
SO-9356-B025 Methanol for LC-MS Optigrade® 2.5 L
UN 1230
CAS number 67-56-1
CH3OH
Assay 99.9 % min.
Water 0.05 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.792 kg (at 20°C)
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Transmissionat 210 nm 40 % min.at 220 nm 60 % min.at 235 nm 80 % min.at 260 nm 98 % min.
Methyl-tert-butyl ether
SO-5398-B025 Methyl-tert-butyl ether HPLC Optigrade® 2.5 L
UN 2398
CAS number 1634-04-4
C5H12O
Assay 99.7 % min.
Water 0.05 % max.
Non-volatile matter 0.0006 % max.
Filtered through 0.2 µm
1 L = 0.742 kg (at 20°C)
Optical absorbance Wavelength1.0 max 270 nm0.3 275 nm0.1 295 nm0.05 310 nm0.01 340 nm
n-Nonane
SO-4436-B010 n-Nonane HPLC Optigrade® 1 L
UN 1920
CAS number 111-84-2
C9H20
Assay 95 % min.
Water 0.01 % max.
Non-volatile matter 0.0003 % max.
Filtered through 0.2 µm
1 L = 0.719 kg (at 20°C)
Optical absorbance Wavelength1.0 max 200 nm0.1 225 nm0.05 250 nm0.005 300 nm
High purity solvents and acids
Code Product Unit
n-Pentane
SO-9081-B010 n-Pentane HPLC Optigrade® 1 L
UN 1265
CAS number 109-66-0
C5H12
Assay 95.0 % min.
Water 0.01 % max.
Non-volatile matter 0.001 % max.
Filtered through 0.2 µm
1 L = 0.626 kg (at 20°C)
Optical absorbance Wavelength1.0 max 200 nm0.7 210 nm0.3 215 nm0.05 225 nm0.01 240 nm
Propan-1-ol
SO-5351-B025 Propan-1-ol HPLC Optigrade® 2.5 L
UN 1274
CAS number 71-23-8
CH3CH2CH2OH
Assay 99.8 % min.
Water 0.05 % max.
Non-volatile matter 0.001 % max.
Filtered through 0.2 µm
1 L = 0.804 kg (at 20°C)
Optical absorbance Wavelength0.5 max 225 nm0.05 250 nm0.01 270 nm0.005 300 nm
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High purity solvents and acids
Code Product Unit
Propan-2-ol
SO-3043-B010 Propan-2-ol HPLC Optigrade® 1 L
SO-3043-B025 Propan-2-ol HPLC Optigrade® 2.5 L
SO-3043-B040 Propan-2-ol HPLC Optigrade® 4 L
UN 1219
CAS number 67-63-0
C3H8O
Assay 99.5 % min.
Water 0.05 % max.
Non-volatile matter 0.0006 % max.
Filtered through 0.2 µm
1 L = 0.786 kg (at 20°C)
Optical absorbance Wavelength1.0 max 205 nm0.3 220 nm0.15 230 nm0.02 254 nm0.01 350 nm
SO-9352-B010 Propan-2-ol for LC-MS Optigrade® 1 L
SO-9352-B025 Propan-2-ol for LC-MS Optigrade® 2.5 L
UN 1219
CAS number 67-63-0
C3H8O
Assay 99.5 % min.
Water 0.05 % max.
Non-volatile matter 0.0006 % max.
Filtered through 0.2 µm
1 L = 0.786 kg (at 20°C)
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Transmissionat 220 nm 60 % min.at 250 nm 99 % min.
High purity solvents and acids
Code Product Unit
Tetrahydrofuran
SO-2858-B010 Tetrahydrofuran HPLC Optigrade® (not stabilised) 1 L
SO-2858-B025 Tetrahydrofuran HPLC Optigrade® (not stabilised 2.5 L
SO-2858-B040 Tetrahydrofuran HPLC Optigrade® (not stabilised) 4 L
UN 2056
CAS number 109-99-9
C4H8O
Assay 99.8 % min.
Water 0.03 % max.
Non-volatile matter 0.0007 % max.
Filtered through 0.2 µm
1 L = 0.887 kg (at 20°C)
not stabilised
Optical absorbance Wavelength1.0 max 212 nm0.5 225 nm0.17 250 nm0.01 300 nm
SO-9364-B010 Tetrahydrofuran for LC-MS Optigrade® (not stabilised) 1 L
SO-9364-B025 Tetrahydrofuran for LC-MS Optigrade® (not stabilised) 2.5 L
UN 2056
CAS number 109-99-9
C4H8O
Assay 99.8 % min.
Water 0.03 % max.
Non-volatile matter 0.0007 % max.
Filtered through 0.2 µm
1 L = 0.887 kg (at 20°C)
not stabilised
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Transmissionat 250 nm 80 % min.at 290 nm 99 % min.
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High purity solvents and acids
Code Product Unit
Toluene
SO-4483-B010 Toluene HPLC Optigrade® 1 L
SO-4483-B025 Toluene HPLC Optigrade® 2.5 L
SO-4483-B040 Toluene HPLC Optigrade® 4 L
UN 1294
CAS number 108-88-3
C7H8
Assay 99.7 % min.
Water 0.03 % max.
Non-volatile matter 0.0005 % max.
1 L = 0.866 kg (at 20°C)
Optical absorbance Wavelength1.0 max 285 nm0.4 288 nm0.15 300 nm0.02 335 nm0.01 350 nm
2,2,4-Trimethylpentane
SO-6043-B010 2,2,4-Trimethylpentane (Isooctane) HPLC Optigrade® 1 L
SO-6043-B025 2,2,4-Trimethylpentane (Isooctane) HPLC Optigrade® 2.5 L
SO-6043-B040 2,2,4-Trimethylpentane (Isooctane) HPLC Optigrade® 4 L
UN 1262
CAS number 540-84-1
C8H18
Assay 99.5 % min.
Water 0.02 % max.
Non-volatile matter 0.0005 % max.
Filtered through 0.2 µm
1 L = 0.690 kg (at 20°C)
Optical absorbance Wavelength1.0 max 205 nm0.2 220 nm0.1 230 nm0.01 254 nm
High purity solvents and acids
Code Product Unit
Water
SO-6795-B025 Water HPLC Optigrade® 2.5 L
SO-6795-B040 Water HPLC Optigrade® 4 L
CAS number 7732-18-5
H2O
Fluorescence at 254 nm (as quinine) 0.1 ppb max.
Fluorescence at 365 nm (as quinine) 0.1 ppb max.
Non-volatile matter 1 mg/L max.
Filtered through 0.2 µm
pH 5.0 - 8.0
This solvent in glass bottles fulfills the specifications according to chapter 4 of the European Pharmacopoeia.
SO-9662-B010 Water ULC-MS Optigrade® 1 L
CAS number 7732-18-5
H2O
Residue after evaporation 0.0001 % w/w max.
Acidity (as Acetic acid) 0.002 % max.
Alkalinity (as Ammonia) 0.00005 % max.
Resistivity (at manuf.) 18.2 Mohm*cm min.
Gradient specificationHPLC gradient at 210 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - H. Peak 0.0005 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
TOC 10 ppb max.
Filter test Passes test
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Microfiltered through 0.1 µm/bottled under inert gas.
SO-4661-B025 Water 0.1 % formic acid ULC-MS Optigrade® 2.5 L
Assay 0.095-0.105 %
Purity of formic acid (GC) 99.0 % min.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - Drift 0.010 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
Transmissionat 210 nm 5 % min.at 230 nm 45 % min.at 254 nm 99 % min.
Al 30 ppb max.Ca 100 ppb max.Fe 50 ppb max.K 100 ppb max.Mg 30 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
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High purity solvents and acids
Code Product Unit
SO-4667-B025 Water 0.1 % acetic acid ULC-MS Optigrade® 2.5 L
Assay 0.095-0.105 %
pH 3.2-3.4
Purity of acetic acid (GC) 99.9 % min.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - Drift 0.010 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
Transmissionat 210 nm 20 % min.at 230 nm 75 % min.at 254 nm 99 % min.
Al 30 ppb max.Ca 100 ppb max.Fe 50 ppb max.K 100 ppb max.Mg 30 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
SO-4673-B025 Water 0.1 % trifluoroacetic acid ULC-MS Optigrade® 2.5 L
Assay 0.095-0.105 %
Purity of trifluoroacetic acid (GC) 99.95 % min.
Gradient specificationHPLC gradient at 254 nm - H. Peak 0.002 AU max.HPLC gradient at 254 nm - Drift 0.010 AU max.
Fluorescence at 254 nm (as quinine) 0.5 ppb max.Fluorescence at 365 nm (as quinine) 0.5 ppb max.
Transmissionat 210 nm 25 % min.at 230 nm 85 % min.at 254 nm 99 % min.
Al 30 ppb max.Ca 100 ppb max.Fe 50 ppb max.K 100 ppb max.Mg 30 ppb max.Na 100 ppb max.
Microfiltered through 0.1 µm/bottled under inert gas.
SO-9368-B010 Water for LC-MS Optigrade® 1 L
SO-9368-B025 Water for LC-MS Optigrade® 2.5 L
CAS number 7732-18-5
H2O
Fluorescence (as quinine at 450 nm) 1x10-7 g max.
Non-volatile matter 1 mg/L max.
pH 5.0 - 8.0
Filtered through 0.2 µm
Ca 0.1 ppm max.K 0.1 ppm max.Mg 0.1 ppm max.Na 0.1 ppm max.
Transmissionat 200 nm - 400 nm 99 % min.
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Appendix I
FDA drug development guidance, reference:
http://www.fda.gov/Drugs/DevelopmentAp-
provalProcess/DevelopmentResources/Drug
InteractionsLabeling/ucm081177.htm
Drug Development and Drug Interactions:
Table of Substrates, Inhibitors and Inducers.
CYP Enzymes, in vitro
Table 1: Chemical inhibitors for in vitro
experiments* (9/25/2006)
Table 2: Preferred and acceptable chemical
substrates for in vitro experiments*
(9/25/2006)
Table 3: Chemical Inducers for in vitro
experiments* (5/1/2006)
P-gp Transporters
Table 9: Acceptable in vitro P-gp substrates*
(5/1/2006)
Table 10: In vitro P-gp inhibitors* (5/1/2006)
* Please note that the FDA states that these lists are notexhaustive. All care has been taken to provide a truerepresentation of the information in these tables withinthis catalogue.
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Appendix II
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