Topical and Systemic Treatments of (People With) Skin Cancer

8/3/2019 Topical and Systemic Treatments of (People With) Skin Cancer

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4th International Conference

for IPT Practitioners

Innovations in Cancer Care

Chicago 2008


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Topical and SystemicTreatments of(people with)

Skin Cancer

Bradford S. Weeks, M.D.Corrective Medicine and Psychiatry

360-341-230 www.weeksmd.com
http://www.weeksmd.com/http://www.weeksmd.com/


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"When an animal dies, it leaves

behind his skin.

When a man dies, all he leavesbehind is his reputation."

Korean Proverb


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Which box are you thinking outside of?


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"A physician once told me that nothing arouses so much

bitter enmity and heated arguments among his

colleagues, as the subject of cancer. This may be due tothe guilty recollections of cancer victims expiring who

might have been saved; or of the memories of patients

pronounced hopelessly ill who recovered under the

treatment of a 'quack,' or who miraculously livedwithout further treatment. Possibly these guilt reactions

and the remorse over exhausting the money of patients

and their relatives in futile cancer treatments, account

for some of these psychological manifestations whichare expressed in hostility and attack."

Nat Morris (written in 1958)


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Even Bill Gates took some risks in life


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"The universities do not teach all

things ... so a doctor must seek out

old wives, gypsies, sorcerers,

wandering tribes, old robbers, and

such outlaws and take lessons fromthem. A doctor must be a traveller.

Knowledge is experience."

Paracelsus

(1493-1541)


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Brief Pictorial Review

of

Human Skin Cancers


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Actinic keratoses may itch or burn.
http://www.medicinenet.com/sun_damaged_skin_pictures_slideshow/article.htm


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Squamous cell cancer effects

men more than women


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Bowens is the earliest form

of squamous cell cancer


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Basal Cell Cancer


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Melanomasoccur anywhere on body


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"ABCDE"

A stands for Asymmetry,B stands for Border,

C for Color,

D for DiameterE for Evolving

~

4 types of melanoma

3 in situ

1 invasive at start


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Antioxidant supplementation and risk of incident

melanomas: results of a large prospective cohort study.

Asgari MM

OBJECTIVE: To examine whether antioxidant supplement use is

associated with melanoma risk in light of recently published data

from the Supplementation in Vitamins and Mineral Antioxidants(SUVIMAX) study, which reported a 4-fold higher melanoma risk in

women randomized to receive a supplement with nutritionally

appropriate doses of antioxidants.

Conclusion: Antioxidants taken in nutritional doses

do not seem to increase melanoma risk.

Arch Dermatol. 2009 Aug;145(8):879-82.


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Centers for Disease Control and Prevention.Sunburn Prevalence Among AdultsUnited

States, 1999, 2003, and 2004.Morbidity and

Mortality Weekly Report2007; 56(21):524-528.


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Blacks are more than three times as

likely as whites to be diagnosed with

melanoma after it has reached a late

stage, and Hispanics are nearly twice

as likely, according to a University of

Miami study released Monday.

http://www.msnbc.msn.com/id/13441328

Bob Marleymalignant melanoma RIP
http://www.msnbc.msn.com/id/13441328http://www.msnbc.msn.com/id/13441328


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Non-sunscreen photoprotection: antioxidants addvalue to a sunscreen.

Matsui MS, et al

Non-sunscreen protective strategies have been developed.

These include topically applied botanical extracts and other

antioxidants as well as topical DNA repair enzymes.

Standard terms of photoprotection such as sun protection

factor (SPF) do not accurately reflect the photoprotection

benefits of these materials.

J Investig Dermatol Symp Proc. 2009 Aug;14(1):56-9.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Matsui%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Matsui%20MS%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract


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Tea extract containing polyphenols via ability to reduce

oxidative stress and inhibit NF-kB.

Botanical antioxidants and vitamins C and E to a broad-

spectrum sunscreen may further decrease UV-induced

damage compared with sunscreen alone.

Conclusion:

Non-sunscreen materials such as botanical extracts,

antioxidants, and DNA repair enzymes can contribute

value when applied topically to human skin in vivo.

J Investig Dermatol Symp Proc. 2009 Aug;14(1):56-9.


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Cancer is not the problem.

Cancer is an adaptive response

to the problem.

Toxic blood and tissue is the

ProblemEvery town has a garbage dump.

Solution: make less trash, recycle.

To avoid cancer: eat non-toxic foods and eat less!


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Removing the tumor is the least

important step in curing cancer.


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Whidbey Island mushroom - Cancer Metaphor


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Basal, squamous cell carcinomasand melanomas and their pre-

cancerous keratotic cousinsrepresent better than 50% of the

average dermatologists work.


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Insulin PotentiationTherapy

Hard on the cancer,

Easy on the patient.


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Threefold approach to treating(people with)

skin cancer

1) get rid of the tumor (least important)

2) take down the cancer welcome sign

3) enhance immune vitality


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Oxygen breathing may be a cheaper and safer alternative to

exogenous erythropoietin (EPO)

Recently discovered normobaric oxygen paradox demonstrates that

renal tissue can be stimulated to increase EPO production via a simple

pattern of oxygen breathing at normal atmospheric pressures. This

leads directly to the hypothesis that oxygen breathing may provide

chemotherapy patients with a convenient and inexpensive alternative to

ESAs. Stimulating endogenous EPO production eliminates the small

risk of immune system reaction associated with ESAs. Further, the

endogenous physiological EPO doses provided by this method may be

safer, in terms of cancer mortality, than the exogenous pharmacological

doses inherent in ESA administration.

Author: R. Burk Medical Hypothesis published on line 5/ 11/ 07


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Change Diet

Change LifestyleChange Level of Enjoyment

Change Beliefs and Attitude.

The Challenge:

People want to be cured with

their sins, not from their sins.


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SUN WORSHIP


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Mom smearing

sunscreen

to avoid.Sunburn


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Does sun exposure increase the

risk of skin cancer?

Poison is a matter of dosage.

Toxicity depends on degree of insult

(dose/time)

and degree of resistance

(nutrient status, immune enthusiasm)


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UVA vs. UVB

sunscreens vs. tanning salons

Goethes dying words:

Mehr Licht!


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Systemic Interventions


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The

Four Bodies

The

Violin Concert
http://../


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Protective effect of pomegranate-derived

products on UVB-mediated damage inhuman reconstituted skin.

Afaq F, et al

Solar ultraviolet (UV) radiation, particularly its UVB

(290-320 nm) component, is the primary cause of

many adverse biological effects including

photoageing and skin cancer.

UVB radiation causes DNA damage, protein

oxidation and induces matrix metalloproteinases


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Pomegranate, from the tree Punica granatum,

contains anthocyanins and hydrolysable tanninsand possesses strong antioxidant and anti-tumor-

promoting properties.

Conclusion:

pomegranate-derived products may be useful

against UVB-induced damage to human skin.

Exp Dermatol. 2009 Jun;18(6):553-61. Epub 2009 Mar 6.


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5-Methyltetrahydrofolate can be photodegraded

by endogenous photosensitizers.

Free Radic Biol Med. 2009 Oct 15;47(8):1199-204.

Epub 2009 Aug 6.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19647791&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19647791&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract


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Beta-carotene prevents ozone-

induced proinflammatorymarkers in murine skin.

Toxicol Ind Health. 2009 May-

Jun;25(4-5):241-7.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19651793&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstracthttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=19651793&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract


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Prevention of the ultraviolet effects on clinical

and histopathological changes, as well as the

heat shock protein-70 expression in mouseskin by topical application of algal UV-

absorbing compounds.

(the red alga Porphyra rosengurttii)

De la Coba, F.

J Dermatol Sci. 2009 Sep;55(3):161-9. Epub

2009 Jul 7.


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Chemoprevention of human actinic keratoses by

topical DL-alpha-tocopherol.

Foote JA et al

Prior research shows that topical application of free,

nonfatty acid-conjugated vitamin E (DL-alpha-

tocopherol) prevents skin cancer in mice, as well as

immunosuppression induced by UVB radiation.

This study investigated the chemopreventivepotential of DL-alpha-tocopherol in humans through

monitoring surrogate end point biomarkers in sun-

damaged skin.


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Conclusion: DL-alpha-tocopherol-inducedreductions in polyamine metabolism are

consistent with the inhibition of skin

squamous cell carcinogenesis as seen in

previous human trials and animal models.

Cancer Prev Res (Phila Pa). 2009Apr;2(4):394-400. Epub 2009 Mar 31.


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A preponderance of evidence from the best

observational studies... has led to the conclusion that

public health action is needed.

Primary prevention of these cancers has been largely

neglected, but we now have proof that the incidence

of colon, breast and ovarian cancer can be reduced

dramatically by increasing the public's intake of

vitamin D."

Professor Cedric Garland the University of San Diego, California

after reviewing 63 recent studies on vitamin D and cancer.


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A daily dose of vitamin D3 could cut the

risk of cancers of the breast, colon and

ovary by up to a half, a 40-year review

of research has found.

The evidence for the protective effect of

the "sunshine vitamin" is so

overwhelming that urgent action must

be taken by public health authorities to

boost blood levels, say cancer specialists.


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Topical Interventions


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Cancerlytic Herbs-

a history of suppression

http://www.altcancer.com/lysis.htm

http://www.meditopia.org/index_ing.htm

Escharotic agents, Fred Mohs, and

Harry HoxseyJD. Elston J. AmericanAcademy of Dermatology, Vol 53, I 3, P 522-524

T i l A t
http://www.altcancer.com/lysis.htmhttp://www.meditopia.org/index_ing.htmhttp://www.meditopia.org/index_ing.htmhttp://www.altcancer.com/lysis.htm


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Topical Agents

iodine (Lugols / SSKI)vitamin A, E, C

selenium

zinccesium

enzymes

raw honey

all can be potentiated with DMSO


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Escharotics (caustic compounds)- botanical ingredients

- metal salt, often a halogen metal (halide),

- potassium iodine

-"butter of antimony" (antimony trichloride)

Many dermatologists are aware that along with

zinc chloride, butter of antimony was one of theingredients in a number of early escharotics of

the 1900's. But its use goes back even to

Paracelsus in the 1500's --


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Curcumin, the yellow pigment found in

the spice turmeric and a key ingredient

in yellow curry inhibits melanoma cell

growth and stimulates tumor cell death

via apoptosis

potent antioxidant, anti-inflammatory

and cancer terminating effects

CANCER August 15, 2005


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Zinc chloride was one of just three

ingredients in the initial Mohs surgicalpaste that is now central to a standard

dermatological procedure approved

through the West. The three ingredientsthat Mohs used in his formula and

taught were: zinc chloride, bloodroot,

and stibnite (antimony sulfide, another

Paracelsus favorite)


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Standard of Care:

Mohs micrographic surgery is the

best procedure to preserve skin

tissue surrounding the cancer. Butit requires special training and

equipment, and it is time-

consuming and expensive.


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Harry S. Hoxsey's formula was almost

identical to Mohs. The difference?Mohs called the topical a "fixative," and he

artificially and unnecessarily inserted the

act of surgery as a necessary part of theprocess. Yet the AMA, FDA and other

pillars of orthodox medicine exerted

enormous effort to put Harry S. Hoxseyout of business


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Zinc chloride has no

capacity to discriminate

healthy from malignant

tissues. the healthy tissue

is definitely not impervious

to this product.

"Zinc chloride is made bypouring hydrochloric acid

over zinc. It is extremely

caustic and may damage

skin."

www.cancersalves.com/

Ingrid Naimen
http://www.cancersalves.com/http://www.cancersalves.com/


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Dr. Jonathan Hartwell, one of the

founders of the National Cancer

Institute, spent most of his adult life

categorizing cancer herbs and

eschoterotics, leaving behind a reference

that would become a classic in the field

of phytopharmacology and ethnobotany.

Jonathan L. Hartwell, Plants Used Against Cancer,Quarterman Publications, Inc., Lawrence, Mass., 1982.

(Out of print).
http://www.meditopia.org/biblio.htmhttp://www.meditopia.org/biblio.htm


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Bloodroot

ointment wasmade and used

by Indians of

the LakeSuperior region

to treat cancer,even uterine.

S i i d i


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Sanguinaria canadensis

The Doctrine of Signatures


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The Doctrine of Signatures

(bloodroot)


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THE LEG


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THE SHOULDER


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THE CHEST


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THE CHEEK


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THE BACK


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Temporary

fever

from a

hot shower

Hypotheramia


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HOMEOSTASIS

Hypotheramia

Hypoglycemia

Hypertheramia

Hyperglycemia

Gi th


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Give me the power

to create a feverand I will cure

all illnesses.

Parmenides (540-480 b.c.)


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Topical, localized Fever

duration ~ 24 hours


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Anti-Cancereffects of

topicalhoneybee venom

(BVT)


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Bee venom induces apoptosis and

inhibits expression ofcyclooxygenase-2 mRNA in human

lung cancer cell line NCI-H1299.

J Pharmacol Sci. 2003 Feb;91(2):95-104. Jang

MH,

Bee venom induces apoptosis andinhibits expression of cyclooxygenase-


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inhibits expression of cyclooxygenase

2 mRNA in human lung cancer cell

line NCI-H1299.

J Pharmacol Sci. 2003 Feb;91(2):95-104.

Jang MH, Shin MC, Seoul, Korea.

Cytotoxic properties of
http://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jang+MH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Shin+MC%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Shin+MC%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jang+MH%22%5BAuthor%5D


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immunoconjugates containingmelittin-like peptide 101 againstprostate cancer: in vitro and invivo studies.Russell PJ, Hewish D, Carter T et al.

The induced apoptosis of


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recombinant adenoviruscarrying melittin gene forhepatocellular carcinomacell.[Article in Chinese]Li B, Ling CQ, Zhang C Li SX

Inhibitory effect of


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.

recombinant adenoviruscarrying melittin gene onhepatocellular carcinoma.Ling CQ, Li B, Zhang CAnn Oncol. 2005 Jan;16(1):109-15


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[Effect of melittin onapoptosis and necrosis ofOsteosarcoma cells]Chen YQ, Zhu ZA, Zhang C

CONCLUSION: Melittin inhibits theproliferation of osterosarcoma cell linethrough up-regulating Fas expressionand inducing apoptsis.

Dear Dr. Weeks,


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Dear Dr. Weeks,

In our studies we successfully

destroyed prostate and breast cancer

tumors and metastases withmembrane disrupting peptides;

examples for these are naturally

occurring peptides like mellitin.


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These peptides destroy the outer

cell membrane and cause rapid

cell death in vitro and in vivo.

Carola Leuschner, PhD


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Anti Skin Cancereffects of

topicalhoneybee venom

(BVT)

Effect of honey bee venom on


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Effect of honey bee venom on

proliferation of K1735M2 mousemelanoma cells in-vitro and growth

of murine B16 melanomas in-vivo.

J Pharm Pharmacol. 2002

Aug;54(8):1083-9.

Liu X, China.
http://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Liu+X%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Liu+X%22%5BAuthor%5D


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Bee venom has been reported to

exhibit antitumour activity in-vitro

and in-vivo.

Apoptosis, necrosis and lysis of

tumour cells were suggested as

possible mechanisms by which beevenom inhibited tumour growth.


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The in-vivo experimentindicated that bee venom

could be used as achemotherapeutic agent

against malignant tumors.

A matrix metalloproteinase 2


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cleavable melittin/avidin

conjugate specifically targets

tumor cells in vitro and in vivo.

Int J Oncol. 2003 Jan;22(1):93-8.

Holle L, Song W,

Melittin alone is extremely toxic
http://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Holle+L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Song+W%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Song+W%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov.offcampus.lib.washington.edu/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Holle+L%22%5BAuthor%5D


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Melittin alone is extremely toxic

to cells and induces immediate celllysis, but becomes inactive when

coupled with avidin.

The incorporation of the MMP2

target sequence into the peptide

was used as a means for targetingtumor cells.


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Considerationof

Risks and Benefits

One of the Arts of Medicine


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SUMMARY


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SUMMARY:

The Standard of Care

is sub-therapeutic.


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"I die by the help oftoo many physicians."

Alexander the Greaton his deathbed, 323 B.C.

SUMMARY (cont.):


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Non-standard of Caretreatment modalities

both Topical and Systemic

exist and are well supported by

scientific literature

as well as clinical practice.


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"Caustics should be triedbefore knife or cautery."

Aulus Cornelius Celsus, the first centuryRoman physician and medical writer in his book

"De medicina," 1478

The Role of Hope


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The Role of Hopeand

The Role ofHaving a

Reason to Live


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Why we offer beyond the standard


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y y

of care therapies?

1) more effective treatment

2) more grateful patients

3) more personal and professional

satisfaction

Dear Dr Weeks


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Dear Dr. Weeks,

After my amazing treatments atyour wonderful clinic, I feel

so fantastic that I thinkI can walk on water.

But I know that you can!


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We all can walk on water.

It is only a matter of motivation.


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Welcome to Come and Visit Us in Seattle!WELCOME TO VISIT US IN SEATTLE !

THE END


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I thank my esteemed friends

and colleaguesfor your kind attention

andinvite any questions

Documents

Topical and Systemic Treatments of (People With) Skin Cancer